otc+-analgezice antipiretice
TRANSCRIPT
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4.3. EXEMPLE DE ANALGEZICE-ANTIPIRETICE
4.3.1. DERIVATI DE ACID SALICILIC
4.3.1.1. ACIDUL ACETILSALICILIC
F-cin.
Absorbie oral bun la nivel gastric i din duodenul superior, BD=68 %,
metabolizare de esterazele intestinale, hepatice, sanguine, apoi glicino i
glucuronocon!ugare "n #icat, $&'=( minute, transport sangvin () % legat de
albumine, distribuie bun "n toate esuturile i eliminare renal *activ i pasiv+
F-din.
Are urmatoarele e#ecte-
- analg!ic"
- an#i$i%#ic"
- an#iin&la'a#(a%"
- an#i)$a)#ic* 'i(#%($*"
- an#iag%gan# $lac+#a%"
uricozuric prin inhib reasorbiei tubulare a acidului uric.
hipocolesterolemiant.
hipolipemiant
Rac,ii ad%)
Are urmtoarele e#ecte-
e#ect ulcerigen.
hipocoagulare la doze mici.
hipercoagulare la doze mari.
retenie hidrosalin i reducerea #iltrrii glomerulare.
eu#orie *stim /01+.
acu#ene.
reacii alergice.
/indrom 2e3e copii sub 4 ani.
into5 Acut iniial alcaloz resp apoi acidoz resp.
doza letal pt copil=) grame aspirin
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C-ind.
ste contraindicate "n- ulcer, astm, diatez hemoragic, sarcin, alergie, i "n
ultima sptm7na "naintea unei operatii chirurgicale, mai mult de ) zile la adult i
mai mult de ( zile la copil
Indica,ii
ste indicat "n- algii, #ebr, a#eciuni in#lamatorii etc
D(! i ad'ini)#%a%
/e d "n urmtoarele doze-
ca analgezicantipiretic- 465),( g&zi la aduli.
ca antiin#lamator- ( g&zi "n ( prize.
ca antiagregant plachetar- ),), g "n priz unic zilnic etc
P%(d/) #i$i!a#
/e prezint sub urmtoarele #orme-
C('$%i'a# d Acid ac)#il)alicilic a 0 'g, cu urmtoarele denumiri comerciale-
Acid Ac)#il)alicilic *9edeon 2ichter, 2om7nia+.
Acid Ac)#il)alicilic */icomed, 2om7nia+.
Acid Ac)#il)alicilic *Bio#arm, 2om7nia+.
Ac)il# *:armacom, 2om7nia+.
- Acid Ac)#il)alicilic */anta /A, 2om7nia+.
- Acid Ac)#il)alicilic *;zone, 2om7nia+.
- 2!($i%in T *;zone
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Fig/%a . Alg($i%in c('$%i'a# &il'a# 115
4.3.1.6.6. An#in%algic P c('$%i'a# :Zn#ia; R('aracetamol () mg.
1o#ein () mg.
Fig/%a . An#in%algic P c('$%i'a# 115
4.3.1.6.3. A)$ac( c('$%i'a# :?i( El SRL; R('
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Fig/%a . A)$ac( c('$%i'a# 115
4.3.1.6.4. A)$i%in Pl/) C c('$%i'a# &%)cn# :?a@%; G%'ania=
C('$(!i,i>
- Acid acetilsalicilic 4)) mg.
Acid Ascorbic '4) mg.Indica,ii
/e administreaz "n tratamentul simptomatic al congestiei nazale, #ebrei i durerii
Fig/%a . A)$i%in Pl/) C c('$%i'a# &%)cn# 115
4.3.1.6.0. Cal'(g%i$in c('$%i'a# :R'dia SRL; R('aracetamol ')) mg.
1o#ein '( mg.
1odein #os#at ) mg
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Fig/%a . Cal'(g%i$in c('$%i'a# 115
4.3.1.6.. E$+i'ig%in c('$%i'a# :E/%($+a%' SA; R('aracetamol '() mg.
1o#ein 6( mg.
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Fig/%a . Fa)c(nal M c('$%i'a# 115
4.3.1.6.1. Fa)c(%' c('$%i'a# :R'dia SRL; R('aracetamol ')) mg.
1o#ein '( mg.
1odein ) mg.
:enobarbital '( mg
Fig/%a . Fa)c(%' c('$%i'a# 115
4.3.1.6.11. N%algi)#($ c('$%i'a# :Fa9i(l SA; R('aracetamol () mg.
1o#ein () mg.
Fig/%a . N%algi)#($ c('$%i'a# 115
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4.3.1.6.16. N(c($i%in c('$%i'a# :CSC P+a%'; L/'9/%g=
C('$(!i,i>
- Acid acetilsalicilic 4)) mg.
1o#ein ' mg.
4.3.1.6.16. U$)a%in Vi#a'in C c('$%i'a# &&. :U$)a; F%an,a=
C('$(!i,i>
- Acid acetilsalicilic ) mg.
Acid ascorbic ')) mg.
Fig/%a . U$)a%in Vi#a'in C c('$%i'a# &&. 115
4.3.1.3. DIFLUNISAL
ste derivat #luorurat al aspirinei
F-cin.
Absorbie oral bun la nivel gastric i din duodenul superior, BD=@@ %,
metabolizare de esterazele intestinale, hepatice, sanguine, apoi glicino i
glucuronocon!ugare "n #icat, $&'=8' minute, transport sangvin () % legat de
albumine, distribuie bun "n toate esuturile i eliminare renal *activ i pasiv+
F-din.
ste analgezic i antiin#lamator mai potent dec7t AA/, iar e#ectul antipiretic este
mai slab dec7t AA/.
Rac,ii ad%)
>oate da-ulcer gastric, acu#ene, reacii alergice etc
C-ind
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ste contraindicate "n- ulcer, astm, diatez hemoragic, sarcin, alptare, alergie,
i "n ultima sptm7na "naintea unei operatii chirurgicale, insu#icien renal grav
Indica,ii
ste indicat "n- algii, #ebr, a#eciuni in#lamatorii
D(! i ad'i)#%a%
/e administreaz ca-
analgezic i antipiretic- g&zi "n ' prize la aduli.
i antiin#lamatoare- ),( g&zi "n ' prize la aduli.
4.3.1.3. ACETILSALICILATUL DE LIZIN
ste prodrog al aspirinei cu hidrosolubilitate crescut
F-cin.
Absorbie oral bun la nivel gastric i din duodenul superior, BD=68 %,
metabolizare de esterazele intestinale, hepatice, sanguine, apoi glicino i
glucuronocon!ugare "n #icat, $&'=@ ore, transport sangvin () % legat de albumine,
distribuie bun "n toate esuturile i eliminare renal *activ i pasiv+
F-din.
Are urmtoarele e#ecte- analgesic, antipiretic, antiin#lamatoare, antispastic
miotrop, antiagregant plachetar, uricozuric prin inhibarea reasorbiei tubulare a
acidului uric, hipocolesterolemiant i hipolipemiant
Rac,ii ad%)
>oate da-ulcer gastric, hipocoagulare la doze mici, hipercoagulare la doze mari,
retenie hidrosalin i reducerea #iltrrii glomerulare, eu#orie prin stimulare /01+,
acu#ene, reacii alergice, sindrom 2e3e copii sub 4 ani, into5icaie acut, iniial
alcaloz respiratorie, apoi acidoz respiratorie
Doza letal pentru copil=) grame aspirin
C-ind.
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ste contraindicat "n- ulcer, astm, diatez hemoragic, sarcin, alergie, i "n
ultima sptm7na "naintea unei operatii chirurgicale, mai mult de ) zile la adult i
mai mult de ( zile la copil
Indica,ii
ste indicat "n- algii, #ebr, a#eciuni in#lamatorii etc
D(! i ad'.
1a analgezic, antiin#lamatoare i antipiretic se d "n doze de- ),( g&ziaduli.
4.3.6. DERIVATI DE PIRAZ2L2NE
4.3.6.1. AMINOFENAZONA
F-cin
Absorbie oral rapid i complet, metabolizare hepatic, $&'=( ore,
distribuie rapid "n esuturi i eliminare renal
F-din.
ste analgezic i antipiretic mai intens dec7t AA/, dar ca antiin#lamator i
antispastic moderat.
Rac,ii ad%)
>oate da-
hipersensibilizare.
tulburri sanguine- leucopenie, anemie, agranulocitoz.
cancer gastric
C-ind.
ste contraindicat "n- sarcin, alergie, leucopenie
Indica,ii
/e utilizeaz "n- algii, #ebr i colici abdominale
D(! i ad'ini)#%a%>
/e administreaz "n doze de ),),6 g&zi "n '4 prize zilnice la aduli.
4.3.6.6. N2RAMIN2FENAZ2NA; METAMIZ2L :cin, #din i reaciile adverse sunt asemntoare amino#enazonei
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D()9i%i
0oramino#enazona este-
analgezic i antispastic mai intens dec7t amino#enazona.
antiin#lamator nesemni#icativ.
antipiretic slab.
nu este incriminat "n inducerea cancerului gastric.
Rac,ii ad%)
>oate da-
ag%an/l(ci#(!*"
noduli la in!ectare im
C-ind.
ste contraindicat "n- sarcin, alergie, leucopenie
Indica,ii
ste indicat "n- algii moderate i intense de toate tipurile, #ebr i colici
abdominale
D(! i ad'ini)#%a%
/e d "n doze de- ),( g&zi "n ' prize zilnice *la aduli+ "n #uncie de calea de
administrare
P%(d/) #i$i!a#
/e prezint sub urmtoarele #orme-
C('$%i'a# d 0 'g, cu urmtoarele denumiri comerciale-
Analgin *uropharm, 2om7nia+.
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Alg(cal'in *entiva /A, 2om7nia+.
Alg(!(n *;zone
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Cn#%algin *1entro#arm, 2om7nia+.
Fa9(cal' *:abiol, 2om7nia+.
M#a'i!(l Fa%'ac(' *:armacom /A, 2om7nia+.
M#a'i!(l */olacium, 2om7nia+.
N((cal'in *Antibiotice /A, 2om7nia+. Sin#(cal' */into#arm /A, 2om7nia+.
Pic*#/%i (%al 0, #lacoane de ) g, cu urmtoarea denumire comercial-
N%algin *$erapia /A, 2om7nia+.
S/$(!i#(a% d 3 'g, cu urmtoarele denumiri comerciale-
N((cal'in *Antibiotice /A, 2om7nia+.
Sin#(cal' */into#arm /A, 2om7nia+.S(l/,i inc#a9il* 0, #iole a ' ml, cu urmtoarea denumire comercial-
Alg(cal'in *entiva /A, 2om7nia+
4.3.6.3. Alg(cal'in 8n c('9ina,ii
4.3.6.3.1. H/a%lin *1hinoin, ngaria+
C('$(!i,i>
Cetamizol 4)) mg
1a#ein 6) mg.
Drotaverin 4) mg
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/e prezint sub #orm de-
C('$%i'a# d 3 'g, cu urmatoarea denumire comercial- P%($i&na!(n*
*Arena 9roup, 2om7nia+.
Fig/%a 10. P%($i&na!(n* c$. 3 'g 115
4.3.3. DERIVAI DE $-AMIN2FEN2L4.3.3.1. PARACETAM2L
ste metabolitul activ al #enacetinei
F-cin.
Absorbie oral bun, BD=88 %, metabolizare hepatic de enzimele /;C,
$&'=' ore, transport sangvin ')() % legat de albumine, distribuie bun "n toate
esuturile i eliminare renal *activ i pasiv+
F-din.
Are urmtoarele e#ecte- analgezic, antipiretic, antiin#lamator, antispastic miotrop,
antiagregant plachetar, uricozuric prin inhibarea reasorbiei tubulare a acidului uric,
hipocolesterolemiant i hipolipemiant
Rac,ii ad%)
>oate da- reacii alergice, rabdomiolize, into5icaie la doze duble #aa de cele
ma5ime de g&zi
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Antidotul "n into5icaiile cu paracetamol este A11, administrat "n primele ' ore
C-ind.
ste contarindicat "n- sarcin, alptare, alergie, insu#iciena hepatic i renal
grav etc
Indica,ii
ste utilizat "n- algii, #ebr, a#eciuni in#lamatorii
D(! i ad'.
/e administreaz ),( g de '4 5 &zi *ma5 4 g &zi+
C('$%i'a# d 0 'g, cu urmtoarele denumiri comerciale-
Pa%ac#a'(l *Cagistra 11, 2om7nia+.
Fig/%a 1. Pa%ac#a'(l c$. 0 'g 115
Pa%ac#a'(l *entiva /A, 2om7nia+.
Pa%ac#a'(l *Antibiotice /A, 2om7nia+.
D&9%il *Bio
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Pa%ac#a'(l *Arena 9roup /A, 2om7nia+.
Pa%ac#a'(l *Bio#arm /A, 2om7nia+.
Pa%ac#a'(l LPJ *arma /A, 2om7nia+.
Pa%ac#a'(l *;zone
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Si%($ 16 'gK0'l, cu urmtoarele denumiri comerciale-
Ad(l; &lac(n a 'l*9ul# >harm, 2om7nia+.
Pa%ac#a'(l; &lac(n a 1 'l*$erapia /A, 2om7nia+.
Si%($ 'gK6'l, cu urmtoarele denumiri comerciale- E&%algan *Bristol Ce3ers /Guibb, :rana+.
S/)$n)i (%al* 16 'gK0'l, cu urmtoarele denumiri comerciale-
Cal$(l *9la5oHellcome
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Plic/%i c/ $/l9% &%)cn#* d B 'gK$lic i d 10 'gK$lic, cu urmtoarele
denumiri comerciale-
E&%algan *Bristol Ce3ers /Guibb, :rana+.
S/$(!i#(a% d B 'g i d 10 'g, cu urmtoarele denumiri comerciale-
E&%algan *Bristol Ce3ers /Guibb, :rana+.
S/$(!i#(a% d 160 'g i d 60 'g, cu urmtoarele denumiri comerciale-
Pa%ac#a'(l *Cagistra 11 /2
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C('$%i'a# 'a)#ica9il d B 'g, cu urmtoarele denumiri comerciale-
Pa%a'id(l *>harmes 2om Ind, :rana+.
4.3.3.6. Pa%ac#a'(l 8n c('9ina,ii
4.3.3.6.1. Alg(!(n &(%# c('$%i'a# :2!(n La9(%a#(%i L#d; Anglia=
C('$(!i,i>
>aracetamol ()) mg.
1o#ein ',8 mg.
1odein ') mg
Fig/%a . Alg(!(n &(%# c('$%i'a# 115
4.3.3.6.6. A$a$ c('$%i'a# &il'a# :US P+a%'acia; P(l(nia=
C('$(!i,i>
>aracetamol ()) mg.
1o#ein 6( mg.
Fig/%a . A$a$ c('$%i'a# &il'a# 115
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4.3.3.6.3. A$a$ C c('$%i'a# &%)cn# :US P+a%'acia; P(l(nia=
C('$(!i,i>
>aracetamol ()) mg.
1o#ein )) mg.
Fig/%a . A$a$ c('$%i'a# &%)cn# 115
4.3.3.6.4. Cal'a&(%# c('$%i'a# :P+a%' R('.Ind.; R('ania=
C('$(!i,i>
>aracetamol )) mg.
1o#ein ( mg.
1odein 8 mg
Fig/%a . Cal'a&(%# c('$%i'a# 115
4.3.3.6.0. Cal'an# &(%# c('$%i'a# :R'dia SRL; R('ania=
C('$(!i,i>
>aracetamol 4)) mg.
:enobarbital () mg.
1o#ein '( mg.
1odein ') mg
Fig/%a . Cal'a&(%# c('$%i'a# 115
4.3.3.6.. Ca&in c('$%i'a# :Alal(id D22; Sl(nia=
C('$(!i,i>
>aracetamol.
1o#ein.
1odein
Fig/%a . Ca&in c('$%i'a# 115
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4.3.3.6.7. C(da'in P c('$%i'a# :T%a$ia; R('ania=
C('$(!i,i>
>aracetamol 4)) mg.
1o#ein ' mg.
1odein ') mg
Fig/%a . C(da'in P c('$%i'a# 115
4.3.3.6.B. C(ld% c('$%i'a# :Gla(S'i#+lin; Anglia=
C('$(!i,i>
>aracetamol ()) mg.
1o#ein '( mg.
:enile#rin ( mg.
$erpin hidrat ') mg.
Acid ascorbic 8 mg
Fig/%a . C(ld% c('$%i'a# 115
4.3.3.6.. C(ld%-/ni(% c('$%i'a# &il'a# :Gla(S'i#+lin; Anglia=
C('$(!i,i>
>aracetamol '() mg.
9uaia#enezin )) mg.
:enile#rin ( mg.
Fig/%a . C(ld%-/ni(% c('$%i'a# &il'a# 115
4.3.3.6.1. C(ld%-Mag%i$ c('$%i'a# &il'a# :Gla(S'i#+lin; Anglia=
C('$(!i,i>
>aracetamol.
1a#ein.
:enile#rin.
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$erpin hidrat.
Acid ascorbic
Fig/%a . C(ld%-Mag%i$ c('$%i'a# &il'a# 115
4.3.3.6.11. C(ld%-Ni# )i%($ :Gla(S'i#+lin; Anglia=
C('$(!i,i - 6 'l c(n,in>
>aracetamol ))) mg.
>rometazin ') mg.
De5trometor#an ( mg.
Fig/%a . C(ld%-Ni# )i%($ 115
4.3.3.6.16. E&%algan i#a'ina C c('$%i'a# && :?%i)#(l M@%) S/i99;
F%an,a=
C('$(!i,i>
>aracetamol ) mg.
Acid ascorbi ')) mg
Fig/%a . E&%algan i#a'ina C c('$%i'a# && 115
4.3.3.6.13. F% $n#%/ ad/l,i-g%an/l $#.)/)$n)i (%al*; $lic/%i :?%i)#(l
M@%) S/i99; F%an,a=
C('$(!i,i- 1 $lic c(n,in>
>aracetamol ()) mg.
Acid ascorbic ')) mg.
:eniramin '( mg
Fig/%a .F% $n#%/ ad/l,i-g%an/l $#.)/)$n)i (%al*; $lic/%i 115
4.3.3.6.14. F% $n#%/ c($ii-g%an/l $#.)/)$n)i (%al*; $lic/%i :?%i)#(l
M@%) S/i99; F%an,a=
C('$(!i,i- 1 $lic c(n,in> >aracetamol '() mg.
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C('$(!i,i- 1 $lic c(n,in>
>aracetamol 6() mg.
:enile#rin clorhidrat ) mg.
Fig/%a . M(da&n J(# d%in $/l9% $#.)/)$. (%al* $lic/%i 115
4.3.3.6.1B. N(-S$algin c('$%i'a# :C+in(in; Unga%ia=
C('$(!i,i>
>aracetamol ()) mg.
Drotaverin 4) mg.
1odein 8 mg
Fig/%a . N(-S$algin c('$%i'a# 115
4.3.3.6.1. Panad(l E#%a c('$%i'a# :Gla(S'i#+lin; Anglia=
C('$(!i,i>
>aracetamol ()) mg.
1o#ein 6( mg
Fig/%a . Panad(l E#%a c('$%i'a# 115
4.3.3.6.6. Pa%ac(& c('$%i'a# :Sin#(&a%'; R(' >aracetamol ()) mg.
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Acid ascorbic )) mg.
1odein #os#at ) mg
Fig/%a . Pa%ag%i$ C c('$%i'a# &il'a# 115
4.3.3.6.66. Sand(% E#%a c('$%i'a# :La%($+a%'; SRL; R('ropi#enazon () mg.
1o#ein anh () mg
Fig/%a . Sand(% E#%a c('$%i'a# 115
4.3.3.6.63. Sa%id(n c('$%i'a# :?a@% El,ia=
C('$(!i,i>
>aracetamol '() mg.
>ropi#enazon () mg.
1o#ein anh '( mg
Fig/%a . Sa%id(n c('$%i'a# 115
4.3.3.6.64. S(l$adin c('$%i'a# i c$.&&. :Gla(S'i#+lin; An=
C('$(!i,i> >aracetamol ()) mg.
1odein #os#at 8 mg.
1o#ein ) mg
Fig/%a . S(l$adin c('$%i'a# i c$.&&. 115
4.3.3.6.60. T%inll c('$%i'a# &il'a# :?i( EEL SRL; R('*nia=
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C('$(!i,i>
>aracetamol ()) mg.
>ropi#enazon )) mg.
1o#ein ?( mg
Fig/%a . T%inll c('$%i'a# &il'a# 115
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