organizational information
TRANSCRIPT
![Page 1: Organizational Information](https://reader036.vdocuments.mx/reader036/viewer/2022070316/5560e45ad8b42a016e8b4e0d/html5/thumbnails/1.jpg)
CHE 5480 Summer 2005 5FG
• Introduction to nanotechnology and supercomputing.
• Instructors: Lloyd L. Lee ([email protected])• Gerald K. Newman ([email protected])
• Henry Neeman ([email protected])• Web page:
coecs.ou.edu/lllee/www/nanocourse2005.html• Class sponsored by National Science Foundation (CISE/EIA)
![Page 2: Organizational Information](https://reader036.vdocuments.mx/reader036/viewer/2022070316/5560e45ad8b42a016e8b4e0d/html5/thumbnails/2.jpg)
Instructors
![Page 3: Organizational Information](https://reader036.vdocuments.mx/reader036/viewer/2022070316/5560e45ad8b42a016e8b4e0d/html5/thumbnails/3.jpg)
What to learn:
• Lectures on nanotechnology
• Learn high performance computing
• Wet labs
• Attend nanotechnology meeting
![Page 4: Organizational Information](https://reader036.vdocuments.mx/reader036/viewer/2022070316/5560e45ad8b42a016e8b4e0d/html5/thumbnails/4.jpg)
Projects:
• Chemical and biosensors
• Nanobiotechnology
• Nanostructures and applications:
• =dendrimers, carbon nanotubes, zeolites, aerogels, nanowires, nanoparticles.
• Nanofluidics
• Nanocomposites (heat management)
• Superhydrophobic surfaces—friction/drag reduction
• Laboratory-on-a-chip
• Homeland security, (others)
![Page 5: Organizational Information](https://reader036.vdocuments.mx/reader036/viewer/2022070316/5560e45ad8b42a016e8b4e0d/html5/thumbnails/5.jpg)
Textbook:
• Eric Drexler, "Engines of Creation" (Anchor Books, 1987)
• Downloadable from Foresight.Org:
• URL http://www.foresight.org/EOC
![Page 6: Organizational Information](https://reader036.vdocuments.mx/reader036/viewer/2022070316/5560e45ad8b42a016e8b4e0d/html5/thumbnails/6.jpg)
![Page 7: Organizational Information](https://reader036.vdocuments.mx/reader036/viewer/2022070316/5560e45ad8b42a016e8b4e0d/html5/thumbnails/7.jpg)
Web Pagecoecs.ou.edu/lllee/www/nano2005.html
![Page 8: Organizational Information](https://reader036.vdocuments.mx/reader036/viewer/2022070316/5560e45ad8b42a016e8b4e0d/html5/thumbnails/8.jpg)
Grading:
• Homeworks 10%
• Midterm Report 20%
• Midterm Presentation 10%
• Midterm Exam 20%
• Final Report 40%
• No final written test.
![Page 9: Organizational Information](https://reader036.vdocuments.mx/reader036/viewer/2022070316/5560e45ad8b42a016e8b4e0d/html5/thumbnails/9.jpg)
Wet Lab:
![Page 10: Organizational Information](https://reader036.vdocuments.mx/reader036/viewer/2022070316/5560e45ad8b42a016e8b4e0d/html5/thumbnails/10.jpg)
Nanotechnology Meeting:Houston, Texas, July 28, 2005
![Page 11: Organizational Information](https://reader036.vdocuments.mx/reader036/viewer/2022070316/5560e45ad8b42a016e8b4e0d/html5/thumbnails/11.jpg)
![Page 12: Organizational Information](https://reader036.vdocuments.mx/reader036/viewer/2022070316/5560e45ad8b42a016e8b4e0d/html5/thumbnails/12.jpg)
![Page 13: Organizational Information](https://reader036.vdocuments.mx/reader036/viewer/2022070316/5560e45ad8b42a016e8b4e0d/html5/thumbnails/13.jpg)
James R. Baker Jr. University of Michigan
Professor, Internal Medicine and Bioengineering
Chief, Division of AllergyDirector, Center for Biologic
Nanotechnology Co-Director, Center for
Biomedical EngineeringBiotechnology, Nanotechnology and Immunology
![Page 14: Organizational Information](https://reader036.vdocuments.mx/reader036/viewer/2022070316/5560e45ad8b42a016e8b4e0d/html5/thumbnails/14.jpg)
Drug Delivery• Research in the area of autoimmune endocrine
disease. He has helped define the basis of the autoimmune response to thyroid auto antigens.
Gene Delivery• Work concerning gene transfer; developing a new
vector system for gene transfer using synthetic polymers (dendrimers).
Anti-microbial research• Work on preventing pathogens from entering the
human body. This research project seeks to develop a composite material that will serve as a pathogen avoidance barrier and post-exposure therapeutic agent to be applied in a topical manner to the skin and mucous membranes.
![Page 15: Organizational Information](https://reader036.vdocuments.mx/reader036/viewer/2022070316/5560e45ad8b42a016e8b4e0d/html5/thumbnails/15.jpg)
Drug Delivery by dendrimers
Project called “smart Bombs”:
Target cancerous cells and leave the normal intact.
• Recognition and diagnosis of cancer
• Drug delivery• Location of c cells• Kill by releasing agents
![Page 16: Organizational Information](https://reader036.vdocuments.mx/reader036/viewer/2022070316/5560e45ad8b42a016e8b4e0d/html5/thumbnails/16.jpg)
Dendrimers• Known for several applications• Able to enter cells• Little toxicityFocus:• High energy lasers or sound wave
energy to trigger the release of the drug out of the dendrimer.
Drug Delivery by dendrimers
![Page 17: Organizational Information](https://reader036.vdocuments.mx/reader036/viewer/2022070316/5560e45ad8b42a016e8b4e0d/html5/thumbnails/17.jpg)
Antimicrobial Nanoemulsion
• Use of soybean oil emulsified with surfactants. Drops ~400 – 600 nm.
• The droplet do not coalesce with themselves . High surface tension make them coalesce with other lipid droplets, killing bacteria.
• Safe for external use. Not safe for red cells, or sperm.
![Page 18: Organizational Information](https://reader036.vdocuments.mx/reader036/viewer/2022070316/5560e45ad8b42a016e8b4e0d/html5/thumbnails/18.jpg)
• The droplets fuse with cell membrane of microorganisms resulting in cell lysis.
• Very effective in killing:
– Bacteria,
– Bacterial spores,
– Enveloped viruses, and
– Fungal spores.
• They are effective at preventing illness in individuals, when used both before and after exposure to the infective agent.
• They could be used:
– Topically,
– As an inhalant.
![Page 19: Organizational Information](https://reader036.vdocuments.mx/reader036/viewer/2022070316/5560e45ad8b42a016e8b4e0d/html5/thumbnails/19.jpg)
• Left: treated with nanoemulsion,
• Right: untreated.• The growth of
bacteria colonies has been eliminated by treatment with nanoemulsion.
Antimicrobial Nanoemulsion
![Page 20: Organizational Information](https://reader036.vdocuments.mx/reader036/viewer/2022070316/5560e45ad8b42a016e8b4e0d/html5/thumbnails/20.jpg)
Gene Transfer
• G-5 dendrimers of Poly(amidoamine)
• The dendrimer is acetyladed to increase solubility.
• Fluorescein is incorporated onto the dendrimer for imaging in vivo.
• Folic acid is then conjugated as targeting agent.
• The final step is to conjugate the therapeutic drug.
![Page 21: Organizational Information](https://reader036.vdocuments.mx/reader036/viewer/2022070316/5560e45ad8b42a016e8b4e0d/html5/thumbnails/21.jpg)
• Into cardiovascular tissues for treatment.
• Use of dendrimer/DNA complexes
–Uniform size, high density, soluble, stable.
• Direct injection or intracoronary delivery.
Gene Transfer
![Page 22: Organizational Information](https://reader036.vdocuments.mx/reader036/viewer/2022070316/5560e45ad8b42a016e8b4e0d/html5/thumbnails/22.jpg)
Enhanced expression of beta-galactosidase in electroporated nonvascularized grafts.
A. Graft treated as in group 12, Figure 1. B. Graft treated as in group 4, Figure 1.
(Original magnification 40).
![Page 23: Organizational Information](https://reader036.vdocuments.mx/reader036/viewer/2022070316/5560e45ad8b42a016e8b4e0d/html5/thumbnails/23.jpg)