organic pharamaceutical chemistry
TRANSCRIPT
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Organic pharamaceutical Organic pharamaceutical chemistrychemistry
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Organic pharamaceutical Organic pharamaceutical chemistrychemistry
• Medicinal chemistry and pharmaceutical chemistry are disciplines at the intersection of chemistry.
• Especially synthetic organic chemistry, and pharmacology and various other biological specialties, where they are involved with design, chemical synthesisand development drug and use people.
• This is called Organic pharamaceutical chemistry.Organic pharamaceutical chemistry.
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Agents for kidney function test
• Number of drugs use measuring the functional capacity of kidney.
• Effective renal plasma flow and tubular functional capacity can ba measured buy use sodium aminohippurate.
• Because of the greater accuracy and low cost of chemical.
• Mainly this drug measure insulin, thiosulpate, mannitol,etc.
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kidney
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Aminohippuric acid • IUPAC name (4-Aminobenzamido)acetic acid.• C9H10N2O3 .
• It is white crystalline solid , It is soluble in water and alcohol and more soluble in acids and alkalies.
• M .W 194.19 g/mol .
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Preparation and uses• PAH free acid prepared with the addition of sodium
hydroxide; it has a pH of 6.7- 7.6.(HCL).
• The sodium aminohippurate injection after sodium bisulphate is added to prevent the darkening of the solution.It is given intravenously in 2 g dose for renal (kidney)function determination.
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Agents for liver function test
• Number of drugs use measuring the functional capacity of liver.
• But most method of determining decreased function(70 to 90%) liver cells damaged.
• Galactose ,Rose bengal,sulpho bromopthalein sodium drugs used to test liver function.
• But sulpho bromopthalein sodium drug is very small persantage damge liver cell.
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liver
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sulpho bromopthalein sodium• IUPAC name bi-soddium-4,5,6,7-tetrsbromo-3,3 –
disulphophenolpthlein.
• C20H8O10Br4S2Na2.
• It is white , crystalline powder that is odourless and hygroscopic in nature .It is souble in water, but insoluble in alcohol and acetone .
• M.W ,838.00 g/mol.
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UsesBromsulphthalein is a dye used in liver function tests. Determining the rate of removal of the dye from the blood stream gives a measure of liver function.
• sulpho bromopthalein sodium testi. Dose : 5 mg /body weight (50kg).ii.45 min interval .iii.Concentration measured 45 min to 2 hur.iv.Result > 5% dye retained, normal working
liver function.
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Agents for pitutiary function test
• Number of drugs use measuring the functional capacity of pitutiary.
• All medicines may cause side effects, but many people have no or minor. This test below side effect rarely, Dizziness; drowsiness;headache; nausea; stomach pain; vomiting.
• Corticorelin,sermatorelin,somatorelin, metyrapone, drugs ueses this test.
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pitutiary
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metyrapone
• IUPAC name 2-methyl-1,2-di(pyridin-3-yl) propan-1-one .
• C14H14N2O.• It is souble in water, but insoluble in alcohol
and acetone .• M.W , 226.274 g/mol.
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Uses• Metyrapone is a drug used for test of pitutiary function test.• First this durg stoppedP-450 enzymes
(metyrapone is metabolized by P-450 enzymes).• Single-dose overnight metyrapone test:
30 mg/kg body weight metyrapone is given orally at 11 PM.• Standard metyrapone test: 750 mg metyrapone is given orally every 4 hours for 24 hours, starting 8 AM.
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By Maruthupandi M , M.sc chemistry ,vivekanada college,Madurai.