Organic Pedagogical Electronic Network What is CH Functionalization? Daniel Morton Emory University Origins of Organic Chemistry Vital Force Vitalism - a doctrine that "living organisms are fundamentally different from non-living entities because they contain some non- physical element or are governed by different principles than are inanimate things". Origins of Organic Chemistry Michel Eugne Chevreul Research on animal fats, elucidating the true nature of soap, discovering the fatty acids, isolating stearic and oleic acids. the great tragedy of science, the slaying of a beautiful hypothesis by an ugly fact Friedrich Whler The first man to synthesize an organic molecule; Urea Synthetic Organic Chemistry Molecular Architecture Synthetic Organic Chemistry Molecular Architecture Considerations Usability Sensitivity Cost Environmental impact/sustainability Efficiency How do we do Chemical Reactions: Bond Strength Kcal/mol considerations Steric shape Electronic environment Functional groups labile under chosen conditions However, they require pre-instillation and generate byproducts Consider a Conventional Reaction: The Wittig Reaction Do we have to use Functional groups? How do we do Chemical Reactions: Bond Strength Kcal/mol Considerations - ubiquity in organic molecules, good vs bad - include different classes of selectivity CH Functionalization Summary slide This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.