optical upconverting nanoparticles for biological applications
DESCRIPTION
Optical Upconverting Nanoparticles for Biological Applications. Alain Richard, Ph. D. Director, Commercialization Life Sciences Valeo Management L.P . Principal Investigator: John Capobianco , Ph.D. Concordia University. Technology. - PowerPoint PPT PresentationTRANSCRIPT
1
Optical Upconverting Nanoparticles for Biological Applications
Alain Richard, Ph. D.Director, Commercialization Life Sciences
Valeo Management L.P.
Principal Investigator:John Capobianco , Ph.D.
Concordia University
2
Technology
22
Synthesis (Colloidal NaYF4)
305 oC – 310 oC
(1 hour)
+
Precursors were added to reaction flask slowly using a stainlesssteel cannula
Trifluoroacetate Precursors + Oleic Acid + Octadecene
Nanoparticles Byproducts
Lanthanide Trifluoroacetates
Oleic Acid
Sodium Trifluoroacetate
Synthesis, characterization and spectroscopy of upconverting lanthanide-doped NaYF4 nanoparticles (NPs). Monodisperse cubic NaYF4 NPs were synthesized via a thermal decomposition reaction. Other particles are available.
3
Technology
4
Competitive AdvantagesThe synthetic method uses technical-grade solvents and ligands; no sophisticated equipment or complicated procedure needed.
Produces highly luminescent and uniform NPs; (27.6 nm ± 1.6)
The colloids of the lanthanide-doped NPs exhibit green/red and blue upconversion luminescence
No background signal in biological samples
No photobleaching
NPs can be excited with a 980 nm laser diode with low power densities (low cost)
5
Market ApplicationsDetection & Imagery:Potential use as biolabels and in biological assays. Ideal for fluorescence resonance energy transfer (FRET) applications. Authentication (e.g. in the ink for bank notes).
Food Safety:A technology development project for the detection of food pathogens is under way with ITEGA in Montreal (Institut de technologie des emballages et du génie alimentaire).
We are seeking an industrial partner in food packaging.
OTHERS: Can be adapted to energy transfer applications (solar energy).
6
Proof Points1- Authenticity: Nanoparticles have been incorporated successfully into ink.
2- The technology has been adapted to water-soluble applications (biological assays; e.g. electrophoresis).
3 -Current project in food safety (pathogen detection)
7
Business Opportunities
Licensing opportunities : all fields currently available
Patent issued in the USA and patent-pending in Canada
Seeking industrial partners; in food packaging, authenticity, biological detection: e.g. diagnostics
• Please contact:
Alain Richard, Ph. D.Director, Commercialization Life Sciences
Valeo Management L.P.355, Peel Street, Office 503, Montréal
T : 1-514-840-1226 ext. 3007 [email protected]