opportunities for biomedical computing and informatics research funding at nih

Opportunities for Biomedical Computing and Informatics Research

Funding at NIH

Zohara Cohen, PhDProgram Director

NIBIB, NIH, DHHS

KOrean Computer Scientists and Engineers Association in America (KOCSEA) Technical Symposium

October 26, 2008

National Institute of Biomedical Imaging & Bioengineering, NIH, DHHS

NIH Mission and StructureNIH Mission and StructureNIH is the steward of medical and behavioral research for the Nation. Its mission is science in pursuit of fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to extend healthy life and reduce the burdens of illness and disability.


NIH StructureNIH Structure

NIA

OD

NIAAA NIAID NIAMS

NCI

NICHD

NIDCD NIDCR NIDDK NIDA

NEI

NIEHS NIGMS

NHLBINHGRI

NIMH NINDS NINR NCCAM

FICNCRR NLMNCMHD

CC CSR CIT

NIBIB


NIBIB MissionThe mission of the National Institute of Biomedical Imaging and Bioengineering is to improve health by leading the development and accelerating the application of biomedical technologies.

NIBIB is committed to integrating the physical and engineering sciences with the life sciences to advance basic research and medical care.


www.nibib.nih.gov


Current NIBIB Portfolio Areas• Biomaterials• Biomedical Informatics• Biosensors• Drug & Gene Delivery Systems• Image-Guided Interventions• Image Processing and Display• Magnetic Resonance Imaging

and Spectroscopy• Mathematical Modeling,

Simulation, and Analysis• Medical Devices and Implant

Science• Micro-Biomechanics• Micro- and Nano-Systems;

Platform Technologies

• Molecular Imaging• Nanotechnology• Nuclear Medicine• Optical Imaging and

Spectroscopy• Rehabilitation Engineering• Sensors• Surgical Tools, Techniques,

and Systems• Telehealth• Tissue Engineering• Ultrasound: Diagnostic and

Interventional• X-ray, Electron, and Ion

Beam

Biomedical Information Science and Technology Initiative (BISTI)

• established in May 2000 to serve as the focus of biomedical computing issues at the NIH

• a consortium of representatives from each of the NIH institutes and centers

• mission: – make optimal use of computer science and technology

to address problems in biology and medicine– foster new basic understandings, collaborations, and

transdisciplinary initiatives between the computational and biomedical sciences

• coordinates research grants, training opportunities, and scientific symposia associated with biomedical computing

http://bisti.nih.gov/


BISTI FOA’s• Innovations in Biomedical Computational Science and

Technology (R01) - PAR-07-344• Exploratory Innovations in Biomedical Computational

Science and Technology (R21) - PAR-06-411• Innovations in Biomedical Computational Science and

Technology Initiative (SBIR [R43/R44]) - PAR-07-160 • Innovations in Biomedical Computational Science and

Technology Initiative (STTR [R41/R42]) - PAR-07-161• Continued Development and Maintenance of Software

(R01) - PAR-08-010http://bisti.nih.gov/


• BISTI

• Roadmap NCBC’s

• Blueprint for Neuroscience

• IMAG

• CTSA Informatics Coordinating Committee

• NanoHealth Enterprise

• PhysioNet Resource

• Osteoarthritis Initiative

• caBIG Imaging Informatics Workspace

National Centers for Biomedical Computing (NCBCs)

www.ncbcs.org


NCBC-Related FOA’s• Collaborations with National Centers for Biomedical

Computing (R01) - PAR-07-249

• Exploratory Collaborations with National Centers for Biomedical Computing (R21) - PAR-07-250

Interagency Modeling and Analysis Group

http://www.defenselink.mil/

http://www.darpa.mil/

http://www.energy.gov/

http://www.usda.gov/

Multiscale Modeling• spans scales from molecular to population• encompasses concepts of space, time and state space• expected to impact the understanding of biological

processes• further the predictive capability in biomedical systems

Genes Cellstructure-function

Tissue structure-function

Clinicalmedicine

Organ structure-function

ProteinsLipids

Carbohydrates

mRNA

…

30,000+genes

100,000+proteins

12 organsystems

1body

200+ celltypes

4 tissuetypes

Courtesy of Peter Hunter


www.nibib.nih.gov/Research/MultiScaleModeling


IMAG Wikihttp://www.imagwiki.org/mediawiki

10 Working Groups

IMAG Multiscale Modeling (MSM) Consortium Working Groups

• WG1 - Filament Dynamics and Simulation (FDS)• WG2 - Cardiac and Skeletal Muscle Physiology• WG3 - Macro-To-Micro Scale Imaging and Transport in Human

Systems• WG4 - Cell Level Modeling• WG5 - High Performance Computing, Computational Issues and

Algorithms• WG6 - Tissue Mechanics• WG7 - Multiscale Imaging• WG8 – Theoretical Methods• WG9 – Nano-modeling• WG10 – Model Sharing

Multiscale Modeling of the Physiome and the NIH vision for

the 21st Century

Grace C.Y. Peng, PhDApril 10-11, 2008

International Physiome Symposium 2008 Toward Holistic Medicine:

Physiome and Oriental MedicineSeoul, Korea


Promoting Global Cooperation and Awarenesshttp://www.imagwiki.org/mediawiki

Please Populate Korea Page

12 NIH participatinginstitutes

3 years, 9 receipt dates

IMAG-Related FOA

PAR 08-023 Objectives• To develop multiscale models that link at least two biological scales

of modeling and accurately predict biomedical and behavioral processes in health and disease states

• To develop predictive, multiscale models that link to higher levels of the physiome. Models must link to at least one scale beyond molecular interactions at the cellular level (e.g. to cell-cell, cell-environment interactions, as listed above)

• To develop predictive, multiscale models that are physiologically mechanistic and have translational potential or clinical applicability

• To bring together modeling and biomedical expertise to collaborate on building multiscale model(s)

• To validate and test models with standard datasets• To develop models that can be explicitly shared with other modelers


NIH Blueprint for Neuroscience Research


Goal: Provide an independent clearinghouse for neuroimaging tools, vocabularies and datasets that promotes adoption and evolution of these resources by providing access, advice, and forums for input and discussion for both developers and the widespread user community.

Neuroimaging Tools and Resources Clearinghouse (NITRC)


www.nitrc.org


NITRC-Related FOAsNIH Blueprint provides supplemental funding to support enhancement of existing neuroimaging informatics tools and resources to improve interoperability, adoptability, dissemination, and usability.

• Neuroimaging Informatics Software Enhancement for Improved Interoperability and Dissemination (R03) – PAR-07-417

• Notice of Availability of Administrative Supplements for Neuroimaging Informatics Software Enhancement for Improved Interoperability and Dissemination - NOT-EB-08-002


BIRN: Biomedical Informatics Research Network

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BIRN and caBIG-Related FOA’s

• Sharing Data and Tools: Federation using the BIRN and caBIG Infrastructures (R01) – PAR-07-426

• Data Ontologies for Biomedical Research (R01) – PAR-07-425

Biotechnology Resource Centers:a NCRR and NIBIB Program


Other Active NIH FOA’s with Relevance to Biomedical Computing and

Informatics• Bioengineering Research Partnerships (R01)

- PAR-07-352• Bioengineering Research Grants (R01)

- PA-07-279 • NLM Express Research Grants in Biomedical

Informatics (R01) - PAR-08-080

http://grants.nih.gov/grants/guide/


Thank You!

Zohara [email protected]

The Future Paradigm: The 4 P’sTransform Medicine from Curative to

Preemptive

PreemptivePersonalizedPredictive

Participatory

opportunities for biomedical computing and informatics research funding at nih

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