SPECIE MOLD FORM YEAST FORM

Sporothrix schenckii Rosette shape @ Gram stain; septate hyphae w/ conidia in daisy wheel patter

Cigar shape

OPPORTUNISTIC

Cryptococcus neoformans - No pseudohyphae; encapsulated

Candida albicans - Blastoconidia, chlamydoconidia, pseudohyphae + germ tube

Aspergillus Uniseriate/biseriate -

SYSTEMIC (Dimorphic)

Histoplasma capsulatum Tuberculate macroconidia Small intracellular yeast

Blastomyces dermititidis Lollipop forms Large yeast cells w/ broad based buds; double contoured wall

Coccidiodes immitis Thick walled; arthroconidia Round walled spherules; Barrel shape

Paracoccidiodes brasiliensis

Similar to lollipop forms Mariner’s wheel-multiple blastoconidia budding from sides of large blastosporeMicky mouse cap

Identical features

SPECIE NAMES OF DISEASES EPIDEMIOLOGY

Sporothrix schenckii Gardener’s Dse, Farmer’s Dse, Rose handler’s Dse, Lymphocutaneous sporotrichosis

Mexico, Brazil, Uruguay and South Africa

OPPORTUNISTIC

Cryptococcus neoformans Meningitis, pulmonary dse, septicemia and major cause of AIDS

Worldwide

Candida albicans Thrush Worldwide

Aspergillus Invasive and Allergic aspergillosis worldwide

SYSTEMIC (Dimorphic)

Histoplasma capsulatum Caver’s Dse, Darling’s Dse, Spelunker’s Dse, Pulmunary Dses, RE cytomycosis

Ohio, Missouri & Mississippi River Valleys

Blastomyces dermititidis North America Blastomycosis, Gilchrist Dse, Chicago Dse

North America, Africa, Mississippi, Ohio River valleys, St. Lawrence River Basin

Coccidiodes immitis Valley Fever, Desert rheumatism San Joaquin valley California, Arizona

Paracoccidiodes brasiliensis South America Blastomycosis , Lutz-Splendore-Almeids Dse, Brazilian blastomycosis, paracoccidiodal granuloma

Central and South America

SPECIE MOT SPECIMEN NOTED TESTS

Sporothrix schenckii Traumatic skin inoculation

OPPORTUNISTIC

Cryptococcus neoformans

Inhalation from pigeons and bird droppings

Spinal fluid India ink (+), Niger seed agar, brown on Bird seed agar

Candida albicans Alteration of host condition as it is NF

Germ tube w/ capsule, Chlamydoconidia on CMA

Aspergillus Airborne/ foodborne Fungus balls @ X-ray, Biopsy, Serological testing

SYSTEMIC (Dimorphic)

Histoplasma capsulatum

Inhalation through bird (avian) and bat droppings

Bone marrow Can be confused w/ Sepedonium

Blastomyces dermititidis

Inhalation of conidia from dog or horses

Can be confused w/ Scedosporium apiospermum; Calcuflour white

Coccidiodes immitis Inhalation Sputum Spheruled yeast

Paracoccidiodes brasiliensis

Inhalation of spores 10-20%KOH