All drugs are considered FDA approved in the U.S. following the passage of the Pure Food and Drugs Act in 1906.http://www.fda.gov/Drugs/InformationOnDrugs/ApprovedDrugs/

* The FDA approval year and Market Name is representative of the first three-letter abbreviation of an oncological condition (see legend) in the series. This drug has also been FDA approved for additional disorders.+ According to the National Cancer Institute (http://www.cancer.gov), chemotherapy regimens do not have an official FDA approval, however, each individual molecular component is FDA approved.

Approved 1953 Approved 1953 Approved 1954 Approved 1957 Approved 1959 Approved 1962 Approved 1963 Approved 1964 Approved 1964 Approved 1965 Approved 1966 Approved 1966 Approved 1968 Approved 1969 Approved 1969 Approved 1970 Approved 1971 Approved 1973 Approved 1974 Approved 1975 Approved 1976

Approved 1976 Approved 1977 Approved 1977 Approved 1978 Approved 1979 Approved 1980 Approved 1981 Approved 1981 Approved 1982 Approved 1982 Approved 1983 Approved 1987 Approved 1988 Approved 1989 Approved 1989 Approved 1990 Approved 1990 Approved 1990s Approved 1991 Approved 1991 Approved 1992

Approved 1992 Approved 1992 Approved 1993 Approved 1994 Approved 1995 Approved 1995 Approved 1995 Approved 1995 Approved 1995 Approved 1995 Approved 1996 Approved 1996 Approved 1996 Approved 1996 Approved 1996 Approved 1996 Approved 1996 Approved 1996 Approved 1996 Approved 1996 Approved 1996

Approved 1997 Approved 1997 Approved 1997 Approved 1997 Approved 1997 Approved 1997 Approved 1997 Approved 1997 Approved 1997 Approved 1997 Approved 1998 Approved 1998 Approved 1998 Approved 1998 Approved 1998 Approved 1998 Approved 1998 Approved 1998 Approved 1998 Approved 1998 Approved 1998

Approved 1999 Approved 1999 Approved 1999 Approved 1999 Approved 1999 Approved 1999 Approved 1999 Approved 1999 Approved 1999 Approved 2000 Approved 2000 Approved 2000 Approved 2001 Approved 2001 Approved 2001 Approved 2002 Approved 2002 Approved 2002 Approved 2002 Approved 2002 Approved 2002

Approved 2003 Approved 2003 Approved 2003 Approved 2003 Approved 2003 Approved 2003 Approved 2003 Approved 2003 Approved 2004 Approved 2004 Approved 2004 Approved 2004 Approved 2004 Approved 2004 Approved 2004 Approved 2004 Approved 2004 Approved 2005 Approved 2005 Approved 2006 Approved 2006

Approved 2006 Approved 2006 Approved 2006 Approved 2006 Approved 2007 Approved 2007 Approved 2007 Approved 2007 Approved 2007 Approved 2008 Approved 2008 Approved 2008 Approved 2008 Approved 2008 Approved 2009 Approved 2009 Approved 2009 Approved 2009 Approved 2009 Approved 2009 Approved 2010

Approved 2010 Approved 2010 Approved 2010 Approved 2011 Approved 2011 Approved 2011 Approved 2011 Approved 2011 Approved 2011 Approved 2011 Approved 2011 Approved 2011 Approved 2012 Approved 2012 Approved 2012 Approved 2012 Approved 2012 Approved 2012 Approved 2012 Approved 2012 Approved 2012

Approved 2012 Approved 2012 Approved 2012 Approved 2012 Not Approved+ Not Approved+ Not Approved+ Not Approved+ Not Approved+ Not Approved+ Not Approved+ Not Approved+ Not Approved+ Not Approved+ Not Approved+ Not Approved+ Not Approved+ Not Approved+ Not Approved+ Not Approved+ Not Approved+

Not Approved+ Not Approved+ Not Approved+ Not Approved+ Not Approved+ Not Approved+ Not Approved+ Not Approved+ Not Approved+ Not Approved+ Not Approved+ Not Approved+

NLY/CLE/BLE* BLE/BRE/HEA/NEC/TLY/NLY* MYELOID LEUKEMIA CLE/NLY/HLY/TES/OUT/RTU* BREAST CANCER COLORECTAL CANCER MULTIPLE MYELOMA TESTICULAR CANCER MULTIPLE MYELOMA HODGKIN LYMPHOMA BREAST CANCER MLE/NLE/ELE/BLE* GRAFT-VERSUS-HOST-DISEASE MLE/NLY* HODGKIN LYMPHOMA BRAIN TUMORS BRE/END* HODGKIN LYMPHOMA NLY/HLY/MLE/BRE/GAS/OVA/SCL/THY/BLA* MELANOMA LYMPHOBLASTIC LEUKEMIA

HODGKIN LYMPHOMA BTU/MUM/NLY* BREAST CANCER TES/OVA* MLE/BLY* BREAST CANCER PROSTATE CANCER BLA/ALA/COL* HLY/PTU/CTU* HLY/MLE/MEL/BRE/NCL* SMALL CELL LUNG CANCER MLE/NLY/PRO/BRE* TESTICULAR CANCER OVARIAN CANCER PROSTATE CANCER OVARIAN CANCER MYELOID LEUKEMIA BRE/PRO* CLE/NLY* HAIRY CELL LEUKEMIA SKIN CANCER

BREAST CANCER CLE/SCL* NLY/CLE/HLE* GRAFT-VERSUS-HOST DISEASE CHEM. IND. NAUSEA & VOMITING BREAST CANCER PROSTATE CANCER MEL/HLE/HLY* ESOPHAGEAL CANCER MYELOID LEUKEMIA OPIOD ANALGESIC BREAST CANCER NCL/PAN* PROSTATE CANCER CONTRAST AGENT COLORECTAL CANCER PROSTATE CANCER OPIOD ANALGESIC PROSTATE CANCER HYPERCALCEMIA NON-SMALL CELL LUNG CARCIN

MYELOID LEUKEMIA OPIOD ANALGESIC CHEM. IND. NAUSEA & VOMITING CHEM. IND. NAUSEA & VOMITING BASAL CELL CARCINOMA BREAST CANCER THROMBOCYTOPENIA NON HODGKIN LYMPHOMA BONE CANCER BREAST CANCER MEL/KID* BREAST CANCER OPIOID ANALGESIC OPIOID ANALGESIC MYELOID LEUKEMIA CHEM. IND. NAUSEA & VOMITING BREAST CANCER COLORECTAL CANCER MULTIPLE MYELOMA BREAST CANCER BLADDER CANCER

SKIN CANCER SKIN CANCER TLY/BRE/SKI* BREAST CANCER BREAST CANCER T-CELL LYMPHOMA GRAFT-VERSUS-HOST DISEASE BRAIN TUMORS NCL/BRE* MYELOID LEUKEMIA MYELOID LEUKEMIA PROSTATE CANCER LYMPHOCYTIC LEUKEMIA MLE/GTU* MULTIPLE MYELOMA BREAST CANCER NON HODGKIN LYMPHOMA COLORECTAL CANCER COLORECTAL CANCER LEUKOCYTE GROWTH FACTOR PANCREATIC CANCER

PROSTATE CANCER PROSTATE CANCER CHEM. IND. NAUSEA & VOMITING MUM/MLY* BREAST CANCER NON-SMALL CELL LUNG CARCIN CHEM. IND. NAUSEA & VOMITING NON HODGKIN LYMPHOMA COL/NCL/BRE/BTU/KID/OVA* COLORECTAL CANCER PARATHYROID CARCINOMA LYMPHOBLASTIC LEUKEMIA PANCREATIC CANCER SKIN CANCER GRAFT-VERSUS HOST DISEASE BLO/BMA* NCL/MES* BLE/BLY* KIDNEY CANCER MLE/BLE* COLORECTAL CANCER

CLE/NLY/BLY/MLE* CER/ANA* KIDNEY CANCER T-CELL LYMPHOMA BREAST CANCER BREAST CANCER MYELOID LEUKEMIA BREAST CANCER KIDNEY CANCER LYMPHOCYTIC LEUKEMIA PROSTATE CANCER BONE CANCER MULTIPLE MYELOMA THROMBOCYTOPENIA KID/PAN/BRE* LYMPHOCYTIC LEUKEMIA OVARIAN CANCER T-CELL LYMPHOMA TUMOR LYSIS SYNDROME T-CELL LYMPHOMA PROSTATE CANCER

MULTIPLE MYELOMA BREAST CANCER PROSTATE CANCER PROSTATE CANCER LYMPHOBLASTIC LEUKEMIA HODGKIN LYMPHOMA NON-SMALL CELL LUNG CARCIN MELANOMA MELANOMA BONE MARROW CANCER THYROID CANCER MELANOMA KIDNEY CANCER MYELOID LEUKEMIA THYROID CANCER MULTIPLE MYELOMA PROSTATE CANCER KIDNEY CANCER SKIN CANCER MYELOID LEUKEMIA BREAST CANCER

MYELOID LEUKEMIA COLORECTAL CANCER CHEM. IND. NAUSEA & VOMITING SKI/COL* OVA/TES* HODGKIN LYMPHOMA COLORECTAL CANCER NON HODGKIN LYMPHOMA BREAST CANCER NLY/MLE* KIDNEY CANCER HLY/NLY* MYELOID LEUKEMIA BREAST CANCER HODGKIN LYMPHOMA HODGKIN LYMPHOMA HODGKIN LYMPHOMA BREAST CANCER NON HODGKIN LYMPHOMA COL/ESO/GAS* BIL/BLA/CER/MES/NCL/OVA/PAN*

HLY/NLY* COLORECTAL CANCER COLORECTAL CANCER COLORECTAL CANCER COLORECTAL CANCER PANCREATIC CANCER HODGKIN LYMPHOMA HODGKIN LYMPHOMA NON HODGKIN LYMPHOMA NON HODGKIN LYMPHOMA OVA/TES* HODGKIN LYMPHOMA

( Mercaptopurine ) ( Methotrexate ) ( Busulfan ) ( Chlorambucil ) ( Cyclophosphamide ) ( Fluorouracil ) ( Vincristine ) ( Dactinomycin ) ( Melphalan ) ( Vinblastine ) ( Pipobroman ) ( Thioguanine ) ( Azathioprine ) ( Cytarabine ) ( Procarbazine ) ( Mitotane ) ( Megestrol ) ( Bleomycin ) ( Doxorubicin ) ( Dacarbazine ) ( Amsacrine )

( Lomustine ) ( Carmustine ) ( Tamoxifen ) ( Cisplatin ) ( Daunorubicin ) ( Aminoglutethimide ) ( Estramustine ) ( Mitomycin ) ( Streptozocin ) ( Vindesine ) ( Etoposide ) ( Mitoxantrone ) ( Ifosfamide ) ( Carboplatin ) ( Flutamide ) ( Altretamine ) ( Idarubicin ) ( Diethylstilbestrol ) ( Fludarabine ) ( Pentostatin ) ( Masoprocol )

( Paclitaxel ) ( Teniposide ) ( Cladribine ) ( Tacrolimus ) ( Amifostine ) ( Anastrozole ) ( Bicalutamide ) ( Interferon Alfa-2b ) ( Porfimer ) ( Sargramostim ) ( Acetaminophen & Hydrocodone ) ( Docetaxel ) ( Gemcitabine ) ( Goserelin ) ( Iodixanol ) ( Irinotecan ) ( Leuprolide ) ( Morphine ) ( Nilutamide ) ( Pamidronate ) ( Topotecan )

( Anagrelide ) ( Bromfenac ) ( Dolasetron ) ( Granisetron ) ( Imiquimod ) ( Letrozole ) ( Oprelvekin ) ( Rituximab ) ( Samarium Sm 153 Lexidronam ) ( Toremifene ) ( Aldesleukin ) ( Capecitabine ) ( Celecoxib ) ( Fentanyl ) ( Leflunomide ) ( Ondansetron ) ( Progesterone ) ( Raltitrexed ) ( Thalidomide ) ( Trastuzumab ) ( Valrubicin )

( Alitretinoin ) ( Aminolevulinic Acid ) ( Bexarotene ) ( Epirubicin ) ( Exemestane ) ( Methoxsalen ) ( Sirolimus ) ( Temozolomide ) ( Vinorelbine ) ( Arsenic Trioxide ) ( Gemtuzumab Ozogamicin ) ( Triptorelin ) ( Alemtuzumab ) ( Imatinib ) ( Zoledronic Acid ) ( Fulvestrant ) ( Ibritumomab Tiuxetan ) ( Oxaliplatin ) ( Oxaliplatin, 5-Fluorouracil, & Leucovorin ) ( Pegfilgrastim ) ( Secretin )

( Abarelix ) ( Alfuzosin ) ( Aprepitant ) ( Bortezomib ) ( Conjugated Estrogens ) ( Gefitinib ) ( Palonosetron ) ( Tositumomab ) ( Bevacizumab ) ( Cetuximab ) ( Cinacalcet ) ( Clofarabine ) ( Erlotinib ) ( Methyl Aminolevulinate ) ( Mycophenolic Acid ) ( Palifermin ) ( Pemetrexed ) ( Nelarabine ) ( Sorafenib ) ( Dasatinib ) ( Panitumumab )

( Pegaspargase ) ( Quadrivalent Human Papillomavirus Vaccine ) ( Sunitinib ) ( Vorinostat ) ( Ixabepilone ) ( Lapatinib ) ( Nilotinib ) ( Raloxifene ) ( Temsirolimus ) ( Bendamustine ) ( Degarelix ) ( Folinic Acid ) ( Plerixafor ) ( Romiplostim ) ( Everolimus ) ( Ofatumumab ) ( Pazopanib ) ( Pralatrexate ) ( Rasburicase ) ( Romidepsin ) ( Cabazitaxel )

( Denosumab ) ( Eribulin ) ( Sipuleucel-T ) ( Abiraterone ) ( Asparaginase Erwinia Chrysanthemi ) ( Brentuximab Vedotin ) ( Crizotinib ) ( Ipilimumab ) ( Peginterferon Alfa-2b ) ( Ruxolitinib ) ( Vandetanib ) ( Vemurafenib ) ( Axitinib ) ( Bosutinib ) ( Cabozantinib ) ( Carfilzomib ) ( Enzalutamide ) ( Glucarpidase ) ( Ingenol Mebutate ) ( Omacetaxine ) ( Pertuzumab )

( Ponatinib ) ( Regorafenib ) ( tbo-Filgrastim ) ( Vismodegib ) ( Bleomycin, Etoposide & Cisplatin ) ( Bleomycin, Etoposide, Doxorubicin, Cyclophosphamide, Vincristine, Procarbazine & Prednisone ) ( Capecitabine & Oxaliplatin ) ( Cyclophosphamide, Doxorubicin, Vincristine & Prednisone ) ( Cyclophosphamide, Methotrexate & Fluorouracil ) ( Cyclophosphamide, Vincristine, & Prednisone ) ( Cyclophosphamide, Vincristine, Doxorubicin & Methylprednisolone ) ( Cyclophosphamide, Vincristine, Procarbazine & Prednisone ) ( Cytabarine, Daunorubicin & Etoposide ) ( Doxorubicin & Cyclophosphamide ) ( Doxorubicin, Bleomycin, Vinblastine & Dacarbazine ) ( Doxorubicin, Bleomycin, Vincristine & Etoposide ) ( Doxorubicin, Bleomycin, Vincristine, Etoposide, Prednisone & Cyclophosphamide ) ( Doxorubicin, Cyclophosphamide & Paclitaxel ) ( Etoposide, Prednisone, Vincristine, Cyclophosphamide & Doxorubicin ) ( Fluorouracil & Leucovorin ) ( Gemcitabine & Cisplatin )

( Ifosfamide, Carboplatin & Etoposide ) ( Leucovorin, Fluorouracil & Irinotecan) ( Leucovorin, Fluorouracil & Oxaliplatin ) ( Leucovorin, Fluorouracil, Irinotecan & Bevacizumab ) ( Leucovorin, Fluorouracil, Irinotecan & Cetuximab ) ( Leucovorin, Fluorouracil, Irinotecan & Oxaliplatin ) ( Mechlorethamine, Doxorubicin, Vinblastine, Vincristine, Bleomycin, Etoposide & Prednisone ) ( Mechloroethamine, Vincristine, Prednisone & Procarbazine ) ( Rituximab, Cyclophosphamide, Doxorubicin, Vincristine & Prednisone ) ( Rituximab, Cyclophosphamide, Vincristine & Prednisone ) ( Vinblastine, Ifosfamide, Cisplatin & Mesna ) ( Vincristine, Doxorubicin, Methotrexate & Prednisone )

Purinethol Methotrexate Myleran Leukeran Cytoxan Fluorouracil Oncovin Cosmegen Alkeran Velban Vercyte Thioguanine Imuran Cytosar-U Matulane Lysodren Megace Blenoxane Adriamycin RDF DTIC-Dome Amsacrine

CeeNU BiCNU Nolvadex Platinol Cerubidine Cytadren Emcyt Mutamycin Zanosar Vindesine VePesid Novantrone Ifex Paraplatin Eulexin Hexalen Idamycin DES Fludara Nipent Masoprocol

Taxol Vumon Leustatin Prograf Ethyol Arimidex Casodex Intron A Photofrin Leukine Anexsia Taxotere Gemzar Zoladex Visipaque Camptosar Lupon Depot Kadian Nilandron Aredia Hycamtin

Agrylin Xibrom Anzemet Kytril Aldara Femara Neumega Rituxan Quadramet Fareston Proleukin Xeloda Celebrex Actiq Arava Zofran Prometrium Tomudex Thalomid Herceptin Valstar

Alitretinoin Levulan Targretin Ellence Aromasin Uvadex Rapamune Temodar Navelbine Trisenox Mylotarg Trelstar Depot Campath Gleevec Zometa Faslodex Zevalin Eloxatin Eloxatin Neulasta SecreFlo

Plenaxis UroXatral Emend Velcade Premarin Iressa Aloxi Bexxar Avastin Erbitux Sensipar Clolar Tarceva Metvixia Myfortic Kepivance Alimta Arranon Nexavar Sprycel Vectibix

Oncaspar Gardasil Sutent Zolinza Ixempra Tykerb Tasigna Evista Torisel Treanda Degarelix Fusilev Mozobil Nplate Afinitor Arzerra Votrient Folotyn Elitek Istodax Jevtana

Xgeva Halaven Provenge Zytiga Erwinaze Adcretris Xalkori Yervoy Sylatron Jakafi Vandetanib Zelboraf Inlyta Bosulif Cometriq Kyprolis Xtandi Voraxaze Picato Synribo Perjeta

Iclusig Stivarga Neutroval Erivedge BEP BEACOPP CAPOX CHOP CMF CVP C-VAMP COPP ADE AC ABVD ABVE ABVE-PC AC-T EPOCH FU-LV Gemcitabine/Cisplatin

ICE FOLFIRI FOLFOX FOLFIRI-Bevacizumab FOLFIRI-Cetuximab FOLFIRINOX Stanford V MOPP R-CHOP R-CVP VeIP VAMPAnal Cancer

Basophilic LeukemiaBiliary Tract Cancer

Bladder CancerBlood Cancer

Bone Marrow CancerBrain Tumors Breast Tumors

Cervical CancerColorectal CancerColorectal Tumors

Endometerial CancerEosinophilic Leukemia

Esophageal CancerGastric Cancer

Gastrointestinal TumorsHairy Cell Leukemia

Head CancerHodgkin Lymphoma

Kidney CancerLymphoblastic Leukemia

Lymphoblastic LymphomaLymphocytic LeukemiaMantle Cell Lymphoma

MelanomaMesothelioma

Multiple MyelomaMyeloid Leukemia

Neck CancerNeutrophilic Leukemia

Non Small Cell Lung CarcinomaOvarian Cancer

Pancreatic CancerPancreatic TumorsProstate Cancer

Skin CancerSmall Cell Lung Cancer

T-Cell LymphomaTesticular Cancer

ANA

BLEBILBLABLOBMABTURTUCERCOLCTUENDELE

ESOGASGTUHLEHEAHLYKIDBLEBLYCLEMLYMELMES

MUMMLENECNLENCLOVAPANPTUPROSKISCLTLYTES

SUBCATEGORY ABBREVIATIONS

Oncological DrugsCreated by the Njardarson Group (The University of Arizona): Edon Vitaku, Elizabeth A. Ilardi, Monica A. Fallon, Erik B. Gerlach, Jack Siqueiros, Jón T. Njarðarson