Fewer migraines may mean fewer missed days.

Once-a-day Trokendi XR offers proven migraine prevention

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INDICATIONTrokendi XR® (topiramate) extended-release capsules are used to prevent migraine headaches in adults and adolescents 12 years and older.

Please refer to the Important Safety Information (pages 4 and 5) or visit www.TrokendiXR.com/patient for the full Medication Guide.

* For full terms and conditions, please see the Trokendi XR co-pay savings card, or visit www.TrokendiXR.com.

$0CO-PAY*

Not actual patient. Used for illustrative purposes.

2 Please refer to the Important Safety Information (pages 4 and 5) or visit www.TrokendiXR.com/patient for the full Medication Guide.

The World Health Organization named migraine as one of the 10 most disabling illnesses.

Reducing the frequency of migraines is possibleThere is no cure for migraine, but there is good news: migraine prevention medications may be able to help.

Studies show that 40% of patients with migraine are candidates for prevention therapy—yet only about 12% of patients with migraine take preventive medicine.

If you suffer from migraine, taking preventive medicine may help you miss fewer days.

Migraine impacts 39 million men, women, and children in the United States.

39million

Migraine will affect 30% of women over their lifetime.30%

of women

Migraine Facts

3 Please refer to the Important Safety Information (pages 4 and 5) or visit www.TrokendiXR.com/patient for the full Medication Guide.

The right topiramate dose may help you have more migraine-free days.

Proven for migraine preventionTopiramate is prescribed more than 2.5 times as much as any other migraine prevention medicine. It’s a highly effective medicine, depending on how it’s dosed.

Trokendi XR offers steady, all-day deliveryTrokendi XR is an extended-release version of topiramate that is designed and approved to be taken once a day; immediate-release topiramate is not.

Once-a-day Trokendi XR uses Microtrol® technology

Three types of specially coated microbeads that help achieve all-day migraine prevention coverage

For illustrative purposes only; does not represent Trokendi XR or the actual time medicine is released.

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12

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Rapid-release beads

Intermediate-release beads

Extended-release beads

Migraine Prevention

4 Please refer to the Important Safety Information (pages 4 and 5) or visit www.TrokendiXR.com/patient for the full Medication Guide.

INDICATION

Trokendi XR® (topiramate) extended-release capsules are used to prevent migraine headaches in adults and adolescents 12 years and older.

IMPORTANT SAFETY INFORMATION

Do not take Trokendi XR if you have recently consumed or plan to consume alcohol (i.e., within 6 hours prior to and 6 hours after Trokendi XR use)

Swallow Trokendi XR capsules whole. Do not sprinkle on food, chew, or crush.

What are the possible side effects of Trokendi XR?

Trokendi XR can cause serious side effects, including: Eye problems. Serious eye problems include sudden decrease in vision with or without eye pain or redness, a blockage of fluid that may cause increased pressure in the eye (secondary angle closure glaucoma). Call your healthcare provider right away if you have new eye symptoms, including any new problems with your vision.

Decreased sweating and increased body temperature (fever). People, especially children, should be watched for signs of decreased sweating and fever, especially in hot temperatures. Some people may need to be hospitalized for this condition.

Increased levels of acid in the blood (metabolic acidosis). If left untreated, metabolic acidosis can cause brittle or soft bones (osteoporosis, osteomalacia, osteopenia), kidney stones, can slow the rate of growth in children, and may possibly harm the unborn child of pregnant patients.

High levels of ammonia in the blood. High ammonia in the blood can affect mental activities, slow alertness, cause tiredness, or cause vomiting. Blood ammonia levels have been shown to rise when Trokendi XR is taken with a medicine called valproic acid (e.g., DEPAKENE® and DEPAKOTE®).

Kidney stones. Drink plenty of fluids when taking Trokendi XR to decrease your chances of getting kidney stones.

Low body temperature. Taking Trokendi XR when you are also taking valproic acid may cause a drop in body temperature to less than 95°F, tiredness, confusion, or coma.

Effects on thinking and alertness. Trokendi XR may affect how you think, and can cause confusion and problems with concentration, attention, memory, or speech. Trokendi XR may cause depression or mood problems, tiredness, and sleepiness.

Dizziness or loss of muscle coordination.

The most common side effects include tingling of the arms and legs (paresthesia), not feeling hungry, nausea, weight loss, abnormal vision, a change in the way foods taste, nervousness, speech problems, dizziness, slow reactions, upper respiratory tract infection, sleepiness, diarrhea, pain in abdomen and difficulty with memory. These are not all the possible side effects of Trokendi XR. For more information, ask your healthcare provider or pharmacist.

Important Safety Information

5 Please refer to the Important Safety Information (pages 4 and 5) or visit www.TrokendiXR.com/patient for the full Medication Guide.

(CONTINUED)

Like other antiepileptic drugs, Trokendi XR may cause suicidal thoughts or actions in a very small number of people, about 1 in 500. Before you take Trokendi XR, tell your healthcare provider if you have or have had depression, mood problems, or suicidal thoughts or behavior. Call a healthcare provider right away if you have thoughts about suicide or dying; have attempted to commit suicide; have new or worsening depression or anxiety; feel agitated or restless; experience panic attacks, trouble sleeping (insomnia), or new or worsening irritability; feel or act more aggressive, angry, or violent; act on dangerous impulses; have an extreme increase in activity and talking (mania); or experience other unusual changes in behavior or mood.

Before taking Trokendi XR, tell your healthcare provider about any other medical conditions, including if you have kidney problems, kidney stones, or are getting kidney dialysis; have a history of metabolic acidosis (too much acid in the blood); have liver problems; have weak, brittle or soft bones (osteomalacia, osteoporosis, osteopenia, or decreased bone density); have lung or breathing problems; have eye problems, especially glaucoma; have diarrhea; have a growth problem; are on a diet high in fat and low in carbohydrates, which is called a ketogenic diet; are having surgery; are pregnant or plan to become pregnant; or if you are breastfeeding. Trokendi XR passes into your breast milk. Breastfed babies may be sleepy or have diarrhea. Talk to your healthcare provider about the best way to feed your baby if you take Trokendi XR.

Trokendi XR can harm your unborn baby. If you take Trokendi XR during pregnancy, your baby has a higher risk for the birth defects of cleft lip, cleft palate, and being smaller than expected at birth. These defects can begin early in pregnancy, even before you know you are pregnant. The long term effects of this are unknown.

Tell your healthcare provider about any other medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements. Trokendi XR and other medicines may affect each other, causing side effects. Especially tell your healthcare provider if you take valproic acid (e.g., DEPAKENE or DEPAKOTE); any medicines that impair or decrease your thinking, concentration, or muscle coordination; or birth control pills. Trokendi XR may make your birth control pills less effective.

Do not stop Trokendi XR without first talking to a healthcare provider. If you have epilepsy and you stop taking Trokendi XR suddenly, you may have seizures that do not stop. Your healthcare provider will tell you how to stop taking Trokendi XR slowly.

Do not drive a car or operate heavy machinery until you know how Trokendi XR affects you. Trokendi XR can slow your thinking and motor skills, and may affect vision.

Please refer to the Medication Guide for additional important patient information.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Important Safety Information

6 Please refer to the Important Safety Information (pages 4 and 5) or visit www.TrokendiXR.com/patient for the full Medication Guide.

Did you know that 100 mg is the recommended total daily dose of topiramate for migraine prevention?

If you are taking immediate-release topiramate (Topamax®) and find yourself on a dose lower than 100 mg a day, it might be time to ask yourself how you are doing:

Are you still suffering from migraines more days than you’d like?

Do you have difficulty taking your medicine as prescribed by your healthcare provider?

If you answered “YES” to either of these questions, tell your healthcare provider how you are doing. It may be time for a switch.

Converting

7 Please refer to the Important Safety Information (pages 4 and 5) or visit www.TrokendiXR.com/patient for the full Medication Guide.

It’s a simple switch from twice-a-day topiramate.Switching to once-a-day Trokendi XR from twice-a-day Topamax is easy and can be done the very next day.

Trokendi XR offers steady 24-hour medicine coverage to help prevent migraines

Once-a-day (Trokendi XR)

Trokendi XR rises in your body and maintains a relatively steady level to ensure medicine coverage all day with just 1 dose.

Twice-a-day (Topamax)

Topamax rises in your body and then drops over the course of 12 hours before the second dose is taken.

100 mg | Once a day

SPN 100

Trokendi XR

50 mg | Twice a day

Topamax

50 50

Capsules and tablets shown are not actual size and color.

Converting

8 Please refer to the Important Safety Information (pages 4 and 5) or visit www.TrokendiXR.com/patient for the full Medication Guide.

Ask your healthcare provider about once-a-day Trokendi XR.

Once-a-day Trokendi XR is available in 4 convenient dosage strengths

100 mg

SPN 100

50 mg

SPN 50

25 mg

SPN 25

200 mg

SPN 200

Capsules shown are not actual size and color.

Dosing

9 Please refer to the Important Safety Information (pages 4 and 5) or visit www.TrokendiXR.com/patient for the full Medication Guide.

Week 4

Take this dose once daily Dates:

When taking topiramate for the first time or converting from immediate-release topiramate, here’s what you can expect:• The recommended daily dose is 100 mg/day

• Trokendi XR can be taken before, during, or after a meal. Swallow capsule whole and intact. Do not sprinkle on food, chew, or crush

• Your healthcare provider is starting you on once-a-day Trokendi XR and may increase the dosage strength over time

• Follow the chart until you reach the full strength of your prescription. Do not stop taking Trokendi XR without talking to your healthcare provider. You may begin noticing results within 4 to 6 weeks

75 mg/day50 mg/day25 mg/day 100 mg/day

SPN 100SPN 50

SPN 50

SPN 25 SPN 25

Week 1

Take this dose once daily Dates:

Week 2

Take this dose once daily Dates:

Week 3

Take this dose once daily Dates:

Dosing

10 Please refer to the Important Safety Information (pages 4 and 5) or visit www.TrokendiXR.com/patient for the full Medication Guide.

You are not alone— we’re here to help.You should always talk to your healthcare provider about any questions you may have, and for information about the migraine treatment plan specifically designed for you. But there are also many websites and organizations where you can find additional information.

Below is a list of trusted resources you may find helpful:

Alliance for Headache Disorders AdvocacyAllianceForHeadacheAdvocacy.org

American Migraine Foundation AmericanMigraineFoundation.org

WebMD—Migraine & Headaches Health Center WebMD.com/migraines-headaches

Migraine Research Foundation MigraineResearchFoundation.org

National Headache Foundation Headaches.org

National Institute of Neurological Disorders and Stroke ninds.nih.gov

The websites listed are not affiliated with, controlled, or endorsed by Supernus Pharmaceuticals, Inc.

Resources

11 Please refer to the Important Safety Information (pages 4 and 5) or visit www.TrokendiXR.com/patient for the full Medication Guide.

Supporting you beyond the prescription.We’re proud to offer Supernus Support, a single point of contact for all of your questions regarding Trokendi XR, including medication access, insurance coverage, and financial aid for eligible patients.

Call us at 1-866-398-0833Monday-Friday, 8 AM-8 PM ET, excluding holidays

All commercially approved patients pay as little as $0 co-pay.*

RxBIN: 610524RxPCN: LoyaltyISSUER: (80840)RxGRP: 50777445

ID: XXXXXXXXXXCall 1-866-398-0833 to activate your card or visit www.TrokendiXR.com to enroll. *Restrictions apply. See back offer for details.

Trokendi XR® Patient Savings and Support Program

per prescription for your next 12 prescriptions*

$0*

AS LITTLE ASPAY B:2.375 in

T:2.125 in

B:3.625 in

T:3.375 in

*For full terms and conditions, please see the Trokendi XR co-pay savings card, or visit www.TrokendiXR.com.

Supernus® Support/ Co-Pay Savings Card

Trokendi XR and Microtrol Technology are registered trademarks of Supernus Pharmaceuticals, Inc. All other trademarks are the property of their respective owners.

© 2020 Supernus Pharmaceuticals, Inc. All rights reserved. SPN.TRO.2020-0060

Please refer to the Important Safety Information (pages 4 and 5) or visit www.TrokendiXR.com/patient for the full Medication Guide.

More migraine-free days may be possible.

SUNDAY MONDAY TUESDAY

Ask your healthcare provider about once-a-day Trokendi XR and visit

www.TrokendiXR.com/patient to learn more.