J.-C. Brisset1,2,3, V. Dousset1,4,5,6, S. Vukusic1,7,8,9,10, F. Cotton1,2,3,11,

OFSEP's investigators

#EP1555 OFSEP MRI protocol: the need of good

practice’s standardization from clinicians

to scientists

This work has been supported by a grant provided by the French State and handled by the "Agence Nationale de la Recherche," within the framework of the

"Investments for the Future" programme, under the reference ANR-10-COHO-002 Observatoire Français de la Sclérose en plaques (OFSEP). It also received

support from the ARSEP Foundation and the Eugène Devic EDMUS Foundation against multiple sclerosis.

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Imaging Working group

“A major epidemiological tool on MS for the scientific community”

The OFSEP’s database is the worldwide biggest collection for MS studies in

term of quality, number of clinical files. The OFSEP’s database is the

worldwide biggest collection for MS studies in term of quality, number of

clinical files. The OFSEP’s database is uniquely offer clinical dataset alongside

to biological samples and MRI data.

OFSEP aims to provide a major epidemiological tool on MS for the scientific

community in France and abroad. This unique dataset, available to anyone

on demand, allows investigators to answer epidemiologic concerns about

causes and mechanisms of MS, effectiveness of treatment, prognosis factor of

disease progression or quality of life of patient.

On Ocotber 2017, the database contains 60,053 clinical datasets from 41

centers, 682 patients’ biological samples from 13 centers and 6,018 MRI

sequences from 442 patients dispatched nationwide onto 17 centers.

For any information, please contact us at: contact@ofsep.org

Meet us at the poster P335 Thursday 3:30pm or check the e-poster eP1555

and also at the OFSEP’s exhibition stall D86.

Fig.2: OFSEP’s imaging group organizational chart Fig.3: OFSEP’s recommended protocol as described on [A,B]

Fig.1: OFSEP’s imaging network

Fig.4: from patient to researchers, the pathway of the MRI data.

Fig.5: Built it activity for MRI data on 2017

References [A] Cotton, F. Suivi en imagerie par résonance magnétique des patients avec une

sclérose en plaques : comment ? Prat. Neurol. - FMC 7, 153–158 (2016).(French)

[B] Cotton, F., Kremer, S., Hannoun, S., Vukusic, S. & Dousset, V. OFSEP, a

nationwide cohort of people with multiple sclerosis: Consensus minimal MRI

protocol. J.Neuroradiol. 42, 133–140 (2015).

Affiliations 1Observatoire Français de la Sclérose en Plaques, France, 2Université de Lyon, Lyon, 3CREATIS-LRMN, UMR 5220 CNRS & U 1044 INSERM & Université de Lyon, Villeurbanne, 4University of Bordeaux, 5Services de Neurologie et Neuroradiologie, CHU de Bordeaux, INSERM-CHU CIC-P 0005, 6Neurocentre Magendie, INSERM U1215,, Bordeaux, 7Service de Neurologie, sclérose en plaques, pathologies de la myéline et neuro-inflammation, 8Fondation Eugène Devic EDMUS contre la Sclérose en Plaques, Hôpital Neurologique Pierre

Wertheimer, Hospices Civils de Lyon, 9Centre des Neurosciences de Lyon, INSERM 1028 et CNRS UMR5292, Lyon, 10Université Claude Bernard Lyon 1, Faculté de Médecine Lyon-Est, Villeurbanne, Auvergne-Rhône-

Alpes, Villeurbanne, 11Service de Radiologie - CHU Lyon, Centre Hospitalier de Lyon Sud, Pierre Bénite, France

* SHAring NeurOImaging Resources An open source web platform for neuro-imaging

Number of Patients on 2017

Amely Roxana (Lyon)

ANDRIEU Asrare (Vannes)

ANXIONNAT René (Nancy)

AUFFAY-CALVIER E. (Nantes)

BANNIER Elise (Rennes)

BARILLOT Christian (Rennes)

BERRY Isabelle (Toulouse)

BING Fabrice (Annecy)

BONCOEUR-MARTEL M-P (Limoges)

BONHOMME Gildas (Lyon)

BONNEVILLE Fabrice (Toulouse)

BONNIER Pierre-Laurent (Lyon)

BOUTET Claire (Saint-Etienne)

BRISSET Jean-Christophe (Lyon)

BROCHET Bruno (Bordeaux)

BRUNEL Hervé (Marseille)

CERVENANSKI Frédéric (Lyon)

COMMOWICK Olivier (Rennes)

CONSTANS Jean-Marc (Amiens)

COTTON Francois (Lyon)

COZE Stéphanie (Marseille)

DARDEL Pascal (Chambéry)

DE SEZE Jerome (Strasbourg)

DEFER Gilles (Caen)

DORY LAUTREC Philippe (Marseille)

DOUSSET Vincent (Bordeaux)

DUGOR Jean-François (Lyon)

DURAND-DUBIEF Françoise (Lyon)

EDAN Gilles (Rennes)

FAKHFAKH Inès (Rennes)

FERRE Jean-Christophe (Rennes)

GALANAUD Damien (Île-de-France)

Gerardin Emmanuel (Rouen)

GIRARD Nadine (Marseille)

GLATTARD Tristan (Lyon)

GONIN Sylvie (Île-de-France)

GRAND Sylvie (Grenoble)

GUILLEVIN Rémy (Poitiers)

GUTTMANN Charles (Boston)

KAIN Michael (Rennes)

KRAINIK Alexandre (Grenoble)

KREMER Stéphane (Strasbourg)

LABAUGE Pierre (Montpellier)

LEHMANN Pierre (Marseille)

LIFTICARIU Consuela (Agen)

MAILLARD Régine (Blois)

MARCEL Sebastien (Chambéry)

MENJOT DE CHAMPFLEUR N. (Montpellier)

MONDOT LYDIANE (Nice)

Nadya Pyatigorskaya (Île-de-France)

OESTERLE Hélène (Colmar)

PAPEIX Caroline (Île-de-France)

PERETTI VITON Paule (Marseille)

PIEROT Laurent (Reims)

RICOLFI Frédéric (Dijon)

ROCH Jean-Amédée (Lyon)

SAPPEY-MARINIER Dominique (Lyon)

SAVATOVSKY Julien (Île-de-France)

STANKOFF Bruno (Île-de-France)

TANGUY Jean-Yves (Angers)

TOUBOULIC Arnaud (Rennes)

TOULGOAT Frédérique (Nantes)

TOURBAH Ayman (Reims)

TOURDIAS Thomas (Bordeaux)

VOGUET BRASIER Charlotte (Dijon)

VUKUSIC Sandra (Lyon)

Any researcher (French or foreign) can request access to the data and samples

collected by OFSEP