Editorial BoardH. E. M. Kay (Joint Editors)G. SlavinjR. A. B. DruryM. S. DunnillG. L. GibsonN. R. GristL. A. HansonM. S. R. HuttW. J. JenkinsD. M. JonesE. J. L. LowburyB. Naylor (USA)M. G. RinslerM. SanderA. I. SpriggsJ. StuartC. Sultan (France)A. VollerR. G. F. Parker (Publications Secretary, Associationof Clinical Pathologists)Joan F. Zilva (representing the Association ofClinical Biochemists)I. C. M. Maclennan (representing the British Societyfor Immunology)EDiTOR British Medical JournalBeryl Flitton (Technical Editor)

General Advisory BoardE. N. AllottRosemary BiggsWilliam Boyd (Canada)Sir Frank M. Burnett (Australia)Sir John Dacie, FRSW. M. DavidsonM. HynesN. H. MartinDorothy S. RussellE. Joan StokesM. M. Wintrobe (USA)

Officers of the Associationof Clinical PathologistsPresident: N. H. AshtonVice-Presidents: C. Giles

I. RanniePresident-Elect: Sir Robert WilliamsChairman of Council: A. C. HuntHonorary Secretary: G. W. PenningtonHonorary Treasurer: J. BurstonMeetings Secretary: Rosalinde Hurley

COMMUNICATIONS Papers submitted for publicationshould be sent in duplicate to the Editor, Journal ofClinical Pathology, BMA House, Tavistock Square,London, WC1H 9JR. They should be in double-spacedtypewriting on one side of the paper only. On the paperthe name of the author should appear with initials (ordistinguishing Christian name) only, and the name andaddress of the laboratory where the work was performed.A definition of the position held by each of the authorsin the hospital or laboratory should be stated in a cover-ing letter to the Editor. All papers with joint authorshipshould be accompanied by the signatures of all theauthors. Results should not be shown as both tables andgraphs.ACKNOWLEDGMENT A stamped addressedpostcard shouldbe enclosed for return to the author as acknowledgmentof receipt of the manuscript. Overseas authors shouldenclose international reply paid coupons.ILLUSTRATIONS Diagrams should be drawn in Indianink on white paper, Bristol board, or blue-squared paper.The legends for illustrations should be typed on a separatesheet. Photographs and photomicrographs should be onglossy paper, unmounted.CHEMICAL FORMULAE should as far as possible be writtenin a single horizontal line.ABBREVIATIONS In general, symbols and abbreviationsshould be those used by the Biochemical Journal.si uNIrS The units in which the author's work wasmeasured should be cited first followed by either thetraditional units if SI units were used or by SI units iftraditional units were used. Such conversion is theresponsibility of the author. In the tables a conversionfactor should be added as a footnote. Authors are referredto J. clin. Path., 27, 590-597.rmcs The critical assessment of papers submitted

will include ethical considerations. Authors are referredto publications on ethics of human experimentationby the Medical Research Council in Britain and to thecode of ethics of the World Medical Association knownas the Declaration of Helsinki (see Brit. med. J., 1964, 2,177).REFERENCES These should be given in the text thus:Jones and Smith (1970). If there are more than twoauthors they should be cited as Jones et al. (1970) eventhe first time that they appear. The list of references

should be typed in double spacing and in alphabeticalorder on a separate sheet. Such references should give theauthor's name, initials, year of publication in brackets,the title of the article quoted, the full name of the journalin which the article appeared, the volume number inarabic numerals followed by the numbers of the first andlast pages of the article.REPRINTS Twenty-five reprints will be supplied free ofcharge. Further reprints will be available on paymentof the necessary costs; the number of reprints requiredshould be sent to the Publishing Manager on the formprovided with the proofs.NOTICE TO ADVERTISERS Applications for advertisementspace and for rates should be addressed to the Advertise-ment Manager, Journal of Clinical Pathology, BMAHouse, Tavistock Square, London, WCIH 9JR.NOTICE TO SUBSCRIBERS The Journal ofClinical Pathologyis published monthly. From January 1979 the annual sub-scription rates including postage by surface mail will be £28in the UK and the Republic of Ireland and US$70.50 inall countries overseas. Payment for overseas subscrip-tions should be made in US dollars, ie, US$70.50, or inyour national currency based on the prevailing exchangerate to the US dollar of that currency, payable to theBritish Medical Association. Orders can also be placedlocally with any leading subscription agent or bookseller.(For the convenience of readers in the USA subscriptionorders, with or without payment, can also be sent toBritish Medical Journal, 1172 Commonwealth Avenue,Boston, Mass. 02134. All enquiries, however, must beaddressed to the Publisher in London.) All enquiries re.garding air mail rates and single copies already publishedshould be addressed to the Publisher in London.COPYRIGHT (D 1978 Journal of Clinical Pathology. Thispublication is copyright under the Berne Convention andthe International Copyright Convention. All rights reser.ved. Apart from any relaxations permitted under nationalcopyright laws, no part of this publication may be repro.duced, stored in a retrieval system or transmitted in anyform or by any means without the prior permission of thecopyright owners. Permission is not, however, required tocopy abstracts of papers or of articles on condition that afull reference to the source is shown. Multiple copying ofthe contents of the publication without permission isalways illegal.

Meningococcal infection and proteolytic control 1181

p. 258. Academic Press, New York.Laurell, C. B., and Jeppsson, J. 0. (1975b). In The Plasma

Proteins, 2nd edition, edited by F. W. Putnam, Vol. 1,p. 257. Academic Press, New York.

Moroi, M., and Aoki, N. (1977). Inhibition of proteasesin coagulation, kinin-forming, and complement systemsby a2-plasmin inhibitor. Journal of Biochemistry, 82,969-972.

Ratnoff, 0. D., and Naff, G. B. (1967). The conversion ofC'ls to C'1 esterase by plasmin and trypsin. Journal ofExperimental Medicine, 125, 337-358.

Ryley, H. C., Neale, M. L., Brogan, T. D., and Bray, P. T.(1975). Screening for cystic fibrosis by analysis ofmeconium for albumin and protease inhibitors. ClinicaChimica Acta, 64, 117-125.

Schorlemmer, H. U., and Allison, A. C. (1976). Effects ofactivated complement components on enzyme secretionby macrophages. Immunology, 31, 781-788.

Requests for reprints to: Dr J. M. Stark, Department ofMedical Microbiology, Welsh National School ofMedicine, Heath Park, Cardiff CF4 4XN, UK.

The November 1978 IssueTHE NOVEMBER 1978 ISSUE CONTAINS THE FOLLOWING PAPERS

Morphology of lymphatic cells and of their derivedtumours FRANCO RILKE, SILVANA PILOTTI, ANTONIO

CARBONE, AND LUCIANO LOMBARDI

Myotonia dystrophica with heart involvement: anelectron microscopic study of skeletal, cardiac, andsmooth muscle R. M. LUDATSCHER, H. KERNER,S. AMIKAM AND B. GELLEI

A critical comparison of the value of pregnancy-associated alpha2-glycoprotein and carcinoem-bryonic antigen assays in patients with colorectalcancer C. B. WOOD, C. H. W. HORNE, C. M. TOWLER,R. W. BURT, J. G. RATCLIFFE, AND L. H. BLUMGART

Human nails and body iron S. SOBOLEWSKI, A. C. K.LAWRENCE, AND P. BAGSHAW

Sensitivity of immunoperoxidase and immuno-fluorescence staining for detecting chlamydia inconjunctival scrapings and in cell culture R. M.WOODLAND, H. EL-SHEIKH, S. DAROUGAR, ANDS. SQUIRES

Diagnosis of Bacteroides fragilis infection withcounter-immunoelectrophoresis 0. A. OKUBADEJO,N. F. LIGHTFOOT, AND W. G. HEWITT

Serological diagnosis of Bacteroidesfragilis infectionsby a complement fixation test CONSTANCE A. C. ROSSAND R. F. GILMORE

Propionibacteria as a cause of shunt and post-neurosurgical infections P. R. SKINNER, A. J.TAYLOR, AND H. COAKHAM

Pitfalls in the use of artificial substrates for thediagnosis of Gaucher's disease YOAV BEN-YOSEPHAND HENRY L. NADLER

Platelet function, factor VIII, fibrinogen, and fibrino-lysis in Nigerians and Europeans in relation toatheroma and thrombosis EVELYNE DUPUY, A. F.FLEMING, AND J. P. CAEN

Failure of factor VIII inhibitor bypassing activityto secure haemostasis in haemophilic patients withantibodies D. H. PARRY AND A. L. BLOOM

Ristocetin and the thrombin clotting time A.ARONSTAM, B. DENNIS, M. N. FRIESEN, W. F. CLARK,A. L. LINTON, AND R. M. LINDSAY

Technical methodsA simple method for plasma exchange R. SLADE,J. REVILL, R. M. HUTCHINSON, AND J. K. WOOD

A new approach to the preparation of bicarbonatesolution for use in virus isolation media A. G.HIGGINSON AND R. L. C. PILE

Myeloperoxidase cytochemistry using 2,7-fluorene-diamine I. BENAVIDES AND D. CATOVSKY

Letter to the Editor

Book reviews

Copies are still available and may be obtained from the PUBLISHING MANAGER,BRITISH MEDICAL ASSOCIATION, TAVISTOCK SQUARE, LONDON, WC1H 9JR, price £3.00, including postage

1186 C. J. Noble

McIntyre, M. (1978). Detection of capsulated Haemo-philus influenzae in chest infections by counter currentimmunoelectrophoresis. Journal of Clinical Pathology,31, 31-34.

Medrek, T. F., and Barnes, E. M. (1962). The influenceof the growth medium on the demonstration of agroup D antigen in faecal streptococci. Journal ofGeneral Microbiology, 28, 701-709.

Niven, C. F. Jr., Smiley, K. L., and Sherman, J. M.(1942). The hydrolysis of arginine by streptococci.Journal of Bacteriology, 43, 651-660.

Parker, M. T., and Ball, L. C. (1976). Streptococci andaerococci associated with systemic infection in man.Journal of Medical Microbiology, 9, 275-302.

Pavlova, M. T., Brezenski, F. T., and Litsky, W. (1972).Evaluation of various media for isolation, enumerationand identification of fecal streptococci from naturalsources. Health Laboratory Science, 9, 289-298.

Raibaud, r., Caulet, M., Galpin, J. V., and Mocquot,

G. (1961). Studies on the bacterial flora of the ali-mentary tract of pigs. II. Streptococci: selectiveenumeration and differentiation of the dominantgroup. Journal of Applied Bacteriology, 24, 285-306.

Sabbaj, J., Suttar, V. L., and Finegold, S. M. (1971).Comparison of selective media for isolation of pre-sumptive group D streptococci from human feces.Applied Microbiology, 22, 1008-1011.

Van der Wiel-Korstanje, J. A. A., and Winkler, K. C.(1975). The faecal flora in ulcerative colitis. Journal ofMedical Microbiology, 8, 491-501.

Williams, R. E. 0. (1958). Laboratory diagnosis ofstreptococcal infections. Bulletin of the World HealthOrganisation, 19, 153-176.

Requests for reprints to: Dr C. J. Noble, Department ofMedical Microbiology, King's College Hospital MedicalSchool, Denmark Hill, London, SES 8RX, UK.

Reports and Bulletins prepared by the Association of Clinical BiochemistsThe following reports and bulletins are published by the Association of Clinical Biochemists. They may be obtainedfrom The Publishing Department, British Medical Journal (ACB Technical Bulletins), B.M.A. House, TavistockSquare, London WC1H 9JR. Overseas readers should remit by British Postal or Money Order.SCIENTIFIC REVIEWS (price £1)00/$2.00 each)

1 The assessment of thyroid function March 1971F. V. FLYNN and J. R. HOBBS

2 Renal function tests suitable for clinical practiceJanuary 1972 F. L. MITCHELL, N. VEALL, and R. W. E.WATTS

3 Biochemical tests for the assessment of fetoplacentalfunctionl May 1975 C. E. WILDE and R. E. OAKEY4 Test of exocrine pancreatic function March 1977A. H. GOWENLOCK

TECHNICAL BULLETINS (price £1-00/$2.00 each)

22 Bilirubin standards and the determination of bilirubinby manual and technicon AutoAnalyzer methodsJanulary 1971 BARBARA BILLING, RUTH HASLAM, and N.WALD

23 Interchangeable cells for spectrophotometers andfluorimeters September 1971 s. S. BROWN and A. H.GOWENLOCK

24 Simple tests to detect poisons March 1972 B. W.MEADE et al.

25 Blood gas analysers May 1972 K. DIXON

26 Kits for enzyme activity determination September1972 s. B. ROSALKI and D. TARLOW

27 Assessment of pumps suitable for incorporation intoexisting continuous flow analytical systems November1972 A. FLECK et al.

28 Routine clinical measurements of transferrin inhuman serum September 1973 K. DIXON29 Control materials for clinical biochemistry (5thedition) September 1973 J. F. STEVENS30 Notes on the quality of performance of serumcholesterol assays September 1973 s. s. BROWN31 Determination of uric acid in blood and in urineJuly 1974 R. W. E. WATTS

32 A survey of amino acid analysers readily available inthe United Kingdom September 1974 J.E. CARLYLE andP. PURKISS

33 Definitions of some words and terms used in auto-mated analysis November 1974 A. FLECK, R. ROBINSON,S. S. BROWN, and J. R. HOBBS

34 Measurement of albumin in the sera of patientsJanuary 1975 LINDA SLATER, P. M. cARTER, and J. R.HOBBS

35 Investigation of the validity of temperature correctionfactors for serum aspartate and alanine transaminasesMarch 1975 s. B. ROSALKI et al.36 Factors influencing the assay ofcreatinine November1975 J. G. H. COOK

37 A survey of enzyme reaction rate analysers readilyavailable in the United Kingdom July 1977 R. A.SAUNDERS and R. F. BURNS

38 Transport of specimens for clinical chemistry an-alysis November 1977 P. WILDING, J. F. ZILVA, andC. E. WILDE

39 A scheme for the evaluation of diagnostic kits May1978 P. H. LLOYD

Book reviews 1257

processing of the tissue obtained. Usefulchapters are included on the interpretationof biopsy specimens and on the cor-relation of renal structure with function.

Pathologists called on to examine renalbiopsies will find this a valuable slimbook to add to those already by theirmicroscope. K. A. PORTER

Notice

Malignant lymphomas

An international course on MalignantLymphomas, sponsored by the BoerhaaveCommittee for Postgraduate MedicalEducation of the University of Leiden,will be held in Noordwijkerhout, TheNetherlands on 3-6 April 1979. Theprogramme is designed for haematolo-gists, immunologists, and pathologists witha special interest in diagnosis, clinicalevaluation, and therapy of patients withmalignant lymphomas. Enquiries shouldbe addressed to: Secretariat of theBoerhaave Committee, University MedicalCenter, Rijnsburgerweg 10, Leiden, TheNetherlands.

Correction

Paper by R. C. Curran and J. Gregory(Volume 31, page 974): in the legends toFigures 1, 2a, and 2b, 'y heavy chain'should have read 'S heavy chain.'

The members of the Editorial Board and the General Advisory Board are indebted to the following for their helpwith the assessment of papers during the year to 30 September 1978:

N. H. AshtonJ. G. AzzopardiD. N. BaronW. T. BarrG. I. BarrowJ. 0. W. BeilbyM. H. BennettBarbara BillingG. W. G. BirdW. K. BlenkinsoppA. L. BloomR. BlowersJ. BoydS. S. BrownM. BrozovicW. BrumfittP. D. ByersH. M. CameronJ. S. CameronR. L. CarterD. CatovskyI. A. J. CavillI. ChanarinJ. ChayenBarbara ClaytonYvonne M. ClaytonJ. G. ColleeP. Mary CotesD. G. CrampR. C. CurranJ. H. DarrellJoan R. DaviesI. M. P. DawsonA. M. DenmanV. DubowitzR. EarlR. P. EkinsJ. L. EmeryJ. M. EnglandR. J. FallonT. FeiziT. H. FlewettP. T. FluteF. V. FlynnH. FoxD. J. GaltonL. P. GarrodH. GayaE. H. GillespieR. R. GilliesA. GoldbergJ. M. GoldmanR. GouldingN. F. C. GowingA. HarknessD. G. F. HarrimanL. I. Hart

F. C. HayB. E. HeardKristin HenryEadie HeydermanR. L. HimsworthJ. R. HobbsA. V. HoffbrandE. J. HolborowR. J. HoltA. C. HuntRosalinde HurleyG. I. C. IngramA. JacobsV. H. T. JamesJ. V. JohannessenH. JohnstonJ. KohnR. W. LaceyD. LambE. LarsenSylvia D. LawlerF. D. LeeB. LennoxElizabeth A. LetskyA. LeveneB. LewisS. M. LewisA. LintonJ. E. MacIverG. P. McNicolA. M. McQueenR. N. M. MacSweenD. McSwigganW. G. P. MairD. Y. MasonP. D. MeersL. MichaelsD. A. MitchisonM. J. MitchinsonM. R. MooreB. C. MorsonD. MossW. R. S. NorthJ. R. O'BrienF. W. O'GradyD. OgstonG. PanayiD. H. ParryR. S. PatrickG. W. PenningtonI. PhillipsL. PollerT. J. PowlesA. B. PriceR. C. B. PughP. R. RaggattLesley H. Rees

W. G. ReevesC. R. RickettsD. S. RidleyS. B. RosalkiB. RoweJ. A. RussellP. SandersonI. H. ScheinbergP. J. ScheuerA. SegalS. SelwynM. S. ShafiD. C. ShansonJ. D. SleighW. SliddersJ. F. SmithD. C. E. SpellerH. SpencerR. C. SpencerW. P. StammA. G. StansfeldC. SternH. SternA. E. StuartA. G. TaylorC. E. D. TaylorD. M. TaylorD. Taylor-RobinsonJ. ThirlwallBrenda ThomasH. ThomasE. J. ThompsonH. ThompsonB. E. TomlinsonP. A. TrottJ. L. TurkD. TyrrellF. WalkerE. A. WallingtonJ. M. WalsheG. WaltersPamela M. WaterworthR. W. E. WattsH. WebbA. D. B. WebsterG. Wetherley-MeinJ. T. WhicherJ. C. WhiteA. E. WilkinsonJ. D. WilliamsSir Robert WilliamsR. WilliamsA. T. WillisM. L. N. WilloughbyN. WoolfA. J. Zuckerman

Volume 31: Author indexAbbreviations and symbols:-'(L)' refersEditor. * indicates first-named author.

to letters to the

ACKRILL, P., 1254 (L)ALLARDYCE, M., 89AL-MONDHIRY, H., 645AL-NAKIB, W., 730*AL-RAWI, A. M., 645AL-TIKRITI, S. A., 194*AMBROSETTI, A., 659AMER, B., 338AMESS, J. A. L., 742AMIKAM, S., 1057AMMANN, A. J., 639*AMYES, S. G. B., 850*ANDERSON, J. M., 469ANDERSON, M., 488*ANSON, A., 447ANTHONY, P. P., 395*APPLETON, P. N., 479*ARCHER, B., 784ARONSTAM, A., 1106*ARRU, E., 475ASHLEY, C. R., 939*AVGOUSTAKI, O., 546AYLIFFE, G. A. J., 923*AYLWARD, D., 909 (L)BABB, J. R., 923BAGSHAW, P., 1068BAILEY, R. R., 620BALITRAND, N., 1244BAMBARA, L. M., 659BARBARA, J. A. J., 288BARNETT, M. D., 742*BARNHAM, M., 189*BARR, R. D., 89*BARR, W. T., 996*BARRETT, A. J., 129*, 124*BARRETT, E., 859*BARTLETT, A., 507BATEMAN, C. J. T., 501* (L)BATESON, M. C., 58BATLIWALA, P. M., 220BAYSTON, R., 434*BEARD, M. E. J., 960BECK, J. S., 469, 551, 1234BENAVIDES, I., 1114*BENJAMIN, S. R., 521BEN-LAYISH, E., 1249BENTLEY, D. P., 956*BENTLEY, S. A., 280BEN-YOSEPH, Y., 1091*BIDWELL, D. E., 507BIDWELL, E., 1117* (L)BLACK, S. H., 309BLENKINSOPP, W. K., 791*, 807* (L), 1143*BLOOM, A. L., 1102BLUMGART, L. H., 1065BOOTH, K., 960BOSMAN, F. T., 69BOUCHIER, I. A. D., 58BOWEN, E. T. W., 201BOWER, L., 447BOYD, J. F., 809*BRAUNSTEIN, H., 265*BRIGGS, M., 521BRITISH SOCIETY FOR CLINICAL CYTOLOGY,

1226*

BROUWER, R., 837BROWN, R. A., 469, 551, 1234BROWN, T. J., 1BRUMFITT, W., 209BRUNT, P. W., 89BUCHANAN, R., 999*BUCHANAN, W. M., 108, 809BUIE, K. J., 827BURNETT, R. A., 108*BURNS, j., 701* (L)BURRELL, C. J., 309*BURT, R. W., 1065CAEN, J. P., 1094CAMERON, C. H., 288*CARBONE, A., 1009CARCASSONNE, Y., 749CASEWELL, M., 845*CASLAKE, M., 382CATOVSKY, D., 1114CAUDRON, M., 250CAUL, E. O., 939CAVILL, 1., 50, 196CAYZER, I., 1147*CEREDIG, R., 578*CHALMERS, S. R., 1147CHARPIN, j., 749CHATTOPADHYAY, B., 1005* (L)CHEW, M. Y., 599*CHITTLEBOROUGH, A. J., 878CHMEL, H., 351CHOUDHURY, M., 44CLARK, W. F., 1106CLAUDE, J. R., 654CLAYTON, R' J., 1143CLEMENT, P. B., 328COAKHAM, H., 1085COATES, D., 148*COBB, S. j., 1161*COHEN, B. J., 179COLE, M. J., 907*COLEMAN, D. j., 724COLEMAN, D. v., 338*COLOE, P. J., 361*, 365*COLOMBO, M., 779CONSTANTOULAKIS, M., 546*COOK, P. J. L., 199* (L)COONEY, T., 233*, 1218CORNALL, R., 500* (L)CORROCHER, R., 659*COWIE, j., 907CUBEAU, J., 654

CURRAN, R. C., 974*CURSONS, R. T. M., 1*DAMLE, P. N., 220DANKERT, J., 370DAROUGAR, S., 1073DARRELL, J. H., 673DAVEY, M. G., 501* (L)DAVIDSON, D. F., 602*DAVIDSON, J. M. F., 1193DAVIDSON, R J. L., 493*DAVIS, P., 721DAY, D. W., 101DAY, W. A., 620DEACON-SMITH, R. A., 883*

1259

DEATH, J. E., 148DELU, A., 772DENG, I. M., 201DENNIS, B., 1106DEPPE, W. M., 872*DESA, D. J., 111DE SANDRE, G., 659DE VRIES, A., 444DEWAR, A. E., 461DIOGUARDI, N., 772DIRKS-GO, S. I. S., 1167*DONIACH, D., 1147DOUGLAS, A. S., 609DRAISEY, T. F., 1207DRISCOLL, J. M., 153, 1255 (L)DUNN, R. I. S., 809DUPUY, E., 1094*DUTTON, J., 806EASTWOOD, M., 39ECONOMIDOU, J., 546EDMUNDS, P. N., 162, 701* (L)EDWARDS, J. M. B., 179*EIDUS, L., 97* (L)ELLARD, G. A., 98* (L)ELLIS, D. S., 201*EL-SHEIKH, H., 1073EMMERSON, A. M.. 850ENDO, S., 156ENGLAND, N. W. j., 295* (L)ESCHWEGE, E., 654*EVANS, D. I. K., 313EVANS, E. G. V., 840EVERALL, P. H., 144*, 423*FAILLE, A., 1244FAKHRI, O., 645*FARISH, E., 382FARR, A. D., 808* (L)FEREMANS, W. W, 250*FERRIS, J. A. J., 198 (L)FISHER, J., 50FLECK, A., 382FLEMING, A. F., 1094FLOWERS, D. J., 855*FONG, R. W., 93FORBES, G. B., 765*FOSTER, W. D., 808 (L)FOX, H., 757FRANCINI, G., 735FRANCIS, D. P., 201FRANCIS, G. E., 963FRASER, J., 1239FREEMAN, R., 832*FRIESEN, M. N., 1106GALLI, M., 735GARDNER, M. D., 1202*GARDNER, S. D., 338GARGAN, R. A., 426*GEARY, C. G., 757*GEE, B., 35*GELLEI, B., 1057GENNARI, C., 735*GEORGE, D., 116GIBSON, P. E., 501* (L)GIDRON, E., 54*GILER, S., 444*

1260

GILL, P., 348GILLESPIE, W. A., 348*GILLILAND, J., 671*GILMORE, R. F., 1083GLUCKMAN, E., 1244GLYNN, A. A., 189GOODMAN, J. R., 639GORDON, Y. B., 742GRAHAM, D. I., 794GRAINGER, J. M., 63, 585*GRANGE, J. M., 378*GREEN, J., 599GREENWOOD, B. M., 213*, 688*, 1177GREENWOOD, D., 12GREGORY, J., 974GRIFFITHS, P. D., 827*GRIST, N. R., 415*GROSS, R. j., 217GUILBAUD, j., 866GUTMAN, J. M., 599GYTE, G. M. L., 125*HAFFENDEN, G. P., 1143HAFIZ, S., 437*, 936HAIM, N., 1249*HALDANE, E. v., 909 (L)HAMBLING, M. H., 183, 832HAMILTON, P. j., 493, 609*HAMILTON-MILLER, J. M. T., 209HAMMERBERG, S., 172*HANCOCK, B. D., 268HAND, M. j., 1228HANLEY, S. A., 633HANN, I. M., 313*HAQQANI, M. T., 268*HARRISON, P., 502 (L)HASLETON, P. S., 116*, 1254* (L)HAWTHORNE, J. H. R., 999HAYES, A. R., 696*HEALY, G. R., 717HEATH, R. B., 827HEATLEY, F. W., 705HEDDELL, G. W., 16*HEIMER, G. V., 185*HENIG, F. F., 444HENSHAW, L. A., 960*HERRON, R., 1116* (L)HEWITT, W. G., 1078HEYNS, A. DU P., 1239*HIGGINSON, A. G., 1112*HILTON, A. L., 348HINCE, C., 292HIRST, D., 101HIRVONEN, j., 949*HOBBS, J. R., 129HOFFBRAND, A. v., 659HOLMES, B., 22*HONZUMI, K., 156HOPKINS, R., 1000*HORNE, C. H. W., 1065HORVATH, E., 591HOUCK, P. W., 1254 (L)HOWARD, C. R., 681*HOWELL, M. F., 390HO-YEN, D. o., 753*HUMBLE, J. G., 129HUNT, J. S., 620HUNTER, N. J., 217HURLEY, R., 98* (L)HUSAIN, 0. A. N., 63*, 585HUTCHINSON, R. M., 1111

HUTTON, R. D., 702* (L)HUTTUNEN, P., 949IBBOTSON, R. M., 1228INGHAM, H. R., 806*INTERNATIONAL COMMITTEE FORSTANDARDIZATION IN HAEMATOLOGY, 275

ISHAK, K. G., 395ISKANDER, S., 502 (L)ISRAEL, M. S., 499*JACKSON, A. M., 794*JAIN, S., 784*JENKINS, M., 521JENKINS, P. A., 1005* (L)JENNINGS, R., 437JENNINGS, R. C., 1125*JEPHCOTT, A. E., 437JOHNSON, I., 47*JOHNSON, T., 904JONES, D. M., 721*JONES, G. R., 99* (L)JONES, P. M., 313JONES, W. G., 50JONSSON, R., 823*JORDAN, B. E., 35JORDAN, T., 1000JOSEPH, N., 185JOUBERT, S. M., 872KANE, A., 878KATCHAKI, J. N., 837*KAUFFMAN, H. F., 370KAYHTY, H., 1172KEALY, W. F., 984KEGEL, D. DE, 175KELLY, J. K., 199* (L)KENDEEL, S. R., 198* (L)KENNY, M. W., 1228*KERNER, H., 1057KERR, E., 909 (L)KERR, E. J. C., 230KHALIL, M. A., 645KNIGHT, R. C., 283*KNOBLOCH, J., 201KONDELIS, N., 1152KOVACS, K., 591KREUNING, J., 69*KRISTENSSON-AAS, A., 823KUIPER, G., 69KUMATA, R., 156KURUVILA, K. C., 220KUTTI, J., 823LACEY, R. W., 165, 700* (L)LAMBERT, J. P., 175LANGLANDS, A. o., 461LAPAGE, S. P., 22LARSEN, A. M., 893LAURIOLA, L., 475LAVER, M. M., 390*LAWRENCE, A. C. K., 1068LAWRENCE, D. A. S., 626*, 1254* (L)LEA, D. J., 527, 1253*LEE-POTTER, J. P., 883LEIGH, D. A., 439*LEINONEN, M., 1172*LELLOUGH, J., 654LEWIS, L. S., 1177LEWIS, S. M., 280, 888*, 1254* (L)LIGHT, A. M., 78*LIGHTFOOT, N. F., 1078LILLEY, H., 730LILLY, H. A., 919*

Author index

LIM, P. L., 223*LINDEMAN, J., 69LINDSAY, R. M., 1106LINTON, A. L., 1106LIVESEY, A. E., 551*LOBBAN, D. I., 913LOLIK, P., 201LOMBARDI, L., 1009LONGHURST, P., 129LORE, F., 735LOSI, C., 1133LOUGH, H., 430LOWBURY, E. J. L., 919LUDATSCHER, R. M., 1057*LYNAM, G., 859LYNN, R., 1193LYNTON-MOLL, C. A., 904*MACAULAY, R. A. A., 461*MCCARTHY, J., 259*MCENTEGART, M. G., 437, 936MACGILLIVRAY, J. B., 551,

560*, 1234MCGIVEN, A. R., 620*MCGOWAN, G. K., 808 (L)MACINTOSH, W. G., 560MCINTYRE, M., 31*MACKENZIE, E. F. D., 338MACKENZIE, J. C., 502 (L)MACKIE, P. H., 648MCLEAN, B. M., 183MACLEOD, T. I. F., 809MCPHIE, J. L., 89MACRAE, A. D., 479MACSWEEN, R. N. M., 108MCSWIGGAN, D. A., 179MANI, R. M., 220*MANLEY, G., 447*MANNUCCI, P. M., 779*MARGALIT, R., 54MARKS, M. I., 172MARRIE, T. J., 909* (L)MARSDEN, H. B., 313MARSHALL, P. N., 280*MASKELL, R., 808* (L)MASON, D. Y., 316*, 454*MATTHEWS, K. B., 488MATTHEWS, N., 1177MAWER, S. L., 12*MEACHIM, G., 1212MEE, J., 817MERZBACH, D., 1249MESHULAM, T., 1249MEURMAN, 0. H., 483*MIDDLETON, 1., 351*MILES, R. S., 355*MILNE, S. E., 933*MISCH, K. A., 116MISKULIN, M., 866*MISTRY, D. K., 648MITCHELL, A. A. B., 16MITCHELL, W. D., 39MITCHISON, D. A., 673*MITCHISON, R., 673MOATI, F., 866MOLLIN, D. L., 742MONTEIL, R., 866MORGAN, L. O., 50*MORRIS, C. A., 144, 423MORTIMER, P. P., 521MORTIMER, P. R., 35

Author index 1261

MOSES, G. C., 1207*MOYES, A., 355MUSIANI, P., 475*NADLER, H. L., 1091NAEYE, R. L., 198* (L)NAIDOO, J., 1187*NAIDOO, P., 872NAPIER, J. A. F., 956NAYAK, N. C., 395NEVE, P., 250NEWMAN, S. P., 784NINFO, V., 1133NOBLE, C. J., 1182*NOBLE, W. C., 1187NUUTINEN, L., 949OBEDEANU, N., 1249ODDS, F. C., 840*0DEGAARD, A., 893*O'DRISCOLL, J., 700*ODUGBEMI, T. O., 936*OKAMURA, H., 156OKUBADEJO, 0. A., 808 (L), 1078*OKUNO, T., 1152*O'NEILL, J. J., 183*ONYEWOTU, I. I., 817*OPHUS, E. M., 893ORCHARD, T. L., 648ORIE, N. G M., 370O'SHEA, M. j., 271PACHOR, M. L., 659PALMER, M. K., 313PAPOZ, L., 654PAREKH, A. C., 93*PARRATT, D., 1161PARRY, D. H., 1102*PASCOE, G. C., 808 (L)PATRICK, R. S., 108PAVER, W. K., 939PAYNE, R. W., 1003*PAYNE, S. B., 521PEKKARINEN, A., 949PENFOLD, J. B., 808 (L)PENNINGTON, C. R., 58*PEQUIGNOT, G., 654PETERS, R., 539PETERSON, P. K., 539PHILLIPS, I., 426, 531*, 705, 845, 1193PHILLIPS, P. J., 671PIANTELLI, M., 475PIETROGRANDE, M., 772PILE, R. L. C., 1112PILOTTI, S., 1009PINKERTON, P. H., 300*PINTOZZI, R. L., 803*POLIN, R. A., 153, 1255 (L)POULDING, J. M., 338POULSEN, H. E., 395POZZUOLI, R., 475PRICE, A. B., 567*PRICE, C. P., 666PRIESTLEY, S. E, 1125PROCTOR, S. j., 259PUBLIC HEALTH LABORATORY SERVICE, Sub-committee on Laboratory Autoclaves,418*

PYKETT, A. H., 536*QUENVILLE, N. F., 328QUORAISHI, A. H., 923RAHMAN, M., 359*RAMPINELLI, L., 1133RAMSAY, D. M., 309

RAPER, C. G. L., 44*, 702* (L)RATCLIFFE, J. G., 1065RATNATUNGA, C. S., 209REALDI, G., 1133RETIEF, F. P., 1239REVILL, J., 1111RICE, E., 1193RICHARD, J. L., 654RICKETTS, C., 196*RIFAAT, U. N., 645RILKE, F., 1009*ROATH, S., 501 (L)ROBERT, A. M., 866ROBERT, L., 866ROBERTS, J. T., 633ROBERTSON, A. J., 469*ROBINSON, E., 1249ROBINSON, J. B., 300RONCHI, G., 779ROSE, M., 47ROSENGURT, N., 129ROSENKRANZ, H. S., 153, 1255 (L)ROSS, C. A. C., 1083*ROSS, P. E., 58ROSS, P. W., 430*ROSS, S., 1000ROTA, L., 779ROWE, B., 217*RUGGE, M., 1133RUSSELL, S. M., 521*RUSSELL, W. J. I., 338RYALL, R. G., 878*RYAN, J. P., 700RYAN, N., 591RYCROFT, S., 295 (L)RYLEY, H. C., 1177SAAL, F., 1244SALM, R., 897*SAMMONS, H. G., 666SAMMONS, R., 454SCHEUER, P. j., 395, 784SCHWARTZ, D., 654SCOTLAND, S. M., 217SCOTT, C. A., 761SCOTT, J. M., 944*SCOTT, R., 1202SEBAHOUN, G., 749*SEIGNEURIN, D., 500* (L)SELKON, J. B., 806SELLIN, M. A., 348SELLWOOD, R. A., 1254 (L)SENN, J. S., 300SHALITIN, Y., 54SHANSON, D. C., 292*SHEPHERD, J., 382*SHERLOCK, S., 784SHIGETA, S., 156*SHILLOM, G. N., 217SHIRGAONKAR, G. V., 220SIEM, T. H., 837SIMMONS, K., 439SIMPSON, D. I. H., 201SIMS, C., 93SIMS, j., 63SINAI, R., 172SINGER, W., 591*SINGH, I., 963*SISSON, P. R., 806SISSONS, H. A., 1121*SKINNER, P. R., 1085*

SLACK, M. P. E., 388SLADE, R., 1111*SLIDDERS, W., 469, 551, 753SMITH, A. M., 1156*SMITH, D. S., 1116 (L)SMITH, J. T., 850SOBIN, L. H., 395SOBOLEWSKI, S., 1068*SOMERS, S., 111SONI, R. P., 220SPARHAM, P. D., 913*SPECK, W. T., 153*, 1255* (L)SPELLER, D. C. E., 913SPERLING, O., 444SPILG, W. G. S., 108SPRIGGS, A. I., 907SPROTT, M. S., 806SQUIRES, S., 1073STALKER, A. L., 609STARK, J. M., 1177*STEPHENS, M., 348STEVENS, A. R., 717STICKLER, D. j., 929STOKES, A., 165*, 700 (L)STOKES, E. J., 933STRONG, W. M., 527*STUART, A. E., 461STUART, j., 488, 648SUEN, K. C., 328*SUTHERLAND, F. 1., 551, 1234*SWANA, G., 1147SWEENEY, E. C., 233, 1218*SWORN, M. J., 999SYED, A. A., 328SYKES, L., 929SZAWATKOWSKI, M., 98* (L)TAYLOR, A. J., 1085TAYLOR, C. E. D., 185TAYLOR, C. R., 316TAYLOR, M. A. R., 840TAYLOR, W. H., 1212TEBBUTT, G. M., 724*TECTOR, M. J., 1228TENNANT, G. B., 227*THAL, S., 681THIBERT, R. J., 1207THOMAS, B., 929*THOMAS, E., 1005 (L)THOMAS, J., 293* (L)THOMPSON, R. A., 1156THOMSON, W H., 956TIZZARD, J. L., 960TOH, B. H., 578TOMKINS, A. M., 712TOWLER, C. M., 1065TREGSON-ROBERTS, G., 633*TREVISAN, A., 1133*TRIBE, C. R., 502* (L)TRICHOPOULOS, D., 546TROVATO, G., 772TRUSTEY, S., 859TUCKWELL, L. A., 348UNSWORTH, P. F., 705*URCA, I., 444URQUHART, G. E. D., 500 (L)VALENTINE, W. H., 808 (L)VANDERVELDE, E. M., 179, 1140*VASUDEV, K. S., 116VERBRUGH, H. A., 539*VERGANI, C., 772*

1262

VERHOEF, j., 539VERVLOET, D., 749VOLLER, A., 507*VRIES, K. DE, 370VYAS, P. R., 220WAITKINS, S. A., 692*WAL, A. M. v.d., 69WALES, J. K., 840

WALKER, F., 194WALKER, R. A., 245*

WARD, D. j., 527, 1253WARD, M., 39*WARDLE, J. M., 888, 1254 (L)WARNER, T. F. C. S., 990WARNOCK, D. W., 99 (L)WARREN, C.. 531WARREN, D. E., 295 (L)WATERFALL, W. E., 1ll*

WATERWORTH, P. M., 531, 933WATKINS, S. M., 125WATSON, D., 136*WATSON, K. C., 230*WATT, A. D., 1000WEBB, A. G. W., 808 (L)WEIR, W. P., 809WENHAM, P. R., 666*WHELDON, D. B., 388*WHITTLE, H. C., 1177WILDEN, J. N., 761*WILKINSON, R., 944WILKINSON, S. P., 101*WILLAERT, E., 717*WILLCOX, W. R., 22WILLIAMS, C. P., 1212*WILLIAMS, K. N., 1193*WILLIAMS, R., 101

Author index

WILLIAMS, R. j., 209*WOOD, C. B., 1065*WOOD, J. K., 1111WOOD, W. S., 328WOODLAND, R. M., 1073*WOZNIAK, J. T., 648*WRIGHT, A. E., 217WRIGHT, S. G., 712*WYCHERLEY, P. A., 271*YARNELL, R., 144YASUNAGA, Y., 156YOUNG, L. F., 499ZANEN, H. C., 1167ZANETTI, A. R., 681ZIOLA, B. R., 483ZISSIS, G., 175*ZUCKERMAN, A. j., 681ZWAN, J. C. VAN DER, 370*

Volume 3 1: Subject indexAbbreviation:-'(L)' refers to letters to the Editor.

Abetalipoproteinaemic plasma lipoproteins, chemical andkinetic study of, 382

Acanthamoeba culbertsoni in case of amoebic meningo-encephalitis, retrospective identification of, 717

Acetoacetate analysis on LKB 8600 Reaction Rate Analyser,602

Achromobacter xylosoxidans, cerebral ventriculitis associatedwith, 156

Acid-fast bacilli, staining of clinical specimens for, use ofmechanical conveyor system (Cyto-Tek) for, 185

Acidic and neutral compounds, volatile, examination for, ingas liquid chromatography for detection of bacteriuria, 859

Acrylamide gel gradient electrophoresis, in study of case oftype III hyperlipoproteinaemia, 599

ACTH syndrome, ectopic, clinicopathological correlationsin, 591

Actin and microsomal antigen in gastric parietal cells,ontogeny of, 578

Adenomatous and hyperplastic parathyroid glands, histo-logical comparison of, 626; 1254 (L)

Adenosine 3',5'-monophosphate and guanosine 3',5'-mono-phosphate, cyclic, urinary excretion in malignancy, 735

Alcohol and hypochlorite mixtures, sporicidal activity of, 148consumption, blood cells and smoking habits, 654

Alkaline phosphatase and peroxidase for double labelling ofcellular constituents, 454

for immunoenzymatic labelling of cellu-lar constituents, 454

(EC 3.1.3.1) activity in plasma in adult populationof Scottish new town (Cumbernauld), frequency distribu-tion and 'reference values' of, 1202

Allografts, renal, human polyomavirus (BK) infection andureteric stenosis in recipients of, 338

Alpha, -antitrypsin. See cx1-AntitrypsinAminoglycosides, E. coli resistance to, specific and non-

specific, 12in cerebrospinal fluid, bioassay of, serum standards for,

172Ammonia in perchloric acid supernate of blood or plasma,

continuous-flow analysis with ammonia-selective electrode,1207

Amoebae, free-living, pathogenicity of, cell cultures asindicator of, 1

Amoebic meningoencephalitis, Acanthamoeba culbertsoni incase of, retrospective identification of, 717

Anaemia, aplastic, marrow graft rejection and inhibition ofgrowth in culture by serum in, 1244

dyserythropoietic, congenital, with unusual cytoplasmicinclusions, 1228

, refractory, and giant lymph node hyperplasia ofmediastinum, 757

Anaerobes, non-sporing, preliminary identification of,nalidixic acid strip method in, 806

Anaerobic bacteria, culture of, comparison of convertedpressure cookers with conventional jars for, 426

blood culture media (L), 98Anaerobiosis, incomplete, as cause of metronidazole

'resistance', 933Analyser, LKB 8600 Reaction Rate, acetoacetate analysis on,

602Anthocyanin BB as nuclear stain substitute for haematoxylin,

194Antibasement membrane antibody, spontaneously occurring,

characterisation of, 639

Antibiotic sensitivity discs as primary antibiotic standards inminimum inhibitory concentration determination, 855

Antibiotics, polyene, in assessment of significance of anti-streptolysin 0 activity, 230

, resistance to, acquisition by Staph. aureus in skinpatients, 1187

sensitivity testing with Sensititre system, 531, 536Antibodies and antigens, viral, in hepatitis B infection, 681

cytomegalovirus-specific, in serum, detection of, com-parison of complement fixation, indirect immuno-fluorescence for viral late antigens, and anti-complementimmunofluorescence tests for, 827

, humoral, to candida and pathogenic yeasts, prevalencein diabetics, 840

, IgM, dithiothreitol for inactivation of, evaluation of,1152

, rubella haemagglutination-inhibition and virus-specificIgM, detection by HAI test with trypsin-treated humangroup 0 erythrocytes, 730

to factor VIII, haemophiliacs with, failure of FEIBA tosecure haemostasis in, 1102

Antibody, rubella, estimation of, comparison of radialhaemolysis with haemagglutination inhibition in, 479,~ ,~' measurement by single radial haemolysis tech-

nique, evaluation of, 521,~ ,~' radial haemolysis in detection of, assessment of,

35to basement membrane, spontaneously occurring,

characterisation of, 639to Candida albicans, radioimmunoassay determination

of levels in healthy and hospitalised adults, 1161to hepatitis B core antigen, detection of, routine use of

counterimmunoelectrophoresis for, 832in acute hepatitis, significance

of, 1140surface antigen in haemophiliacs on

long-term therapy with Scottish factor VIII, 309to rotavirus, fluorescent, method for detection of, and

use in sero-epidemiology (L), 393Anti-complement immunofluorescence test for detection of

cytomegalovirus-specific serum antibodies, comparisonwith complement fixation test and indirect immuno-fluorescence test for viral late antigens, 827

Antigen, carcinoembryonic, assay in colorectal cancer, com-parison with pregnancy-associated OC2-glycoprotein assay,1065

e. See e antigenhepatitis B core, antibody to, detection of, routine use

of counterimmunoelectrophoresis for, 832surface. See Hepatitis B surface antigen

microsomal, and actin in gastric parietal cells, ontogenyof, 578

Antigens and antibodies, viral, in hepatitis B infection, 681, Echinococcus granulosus, most immunoreactive (anti-

gens 4 and 5), in hydatid fluids, specific quantification of,475

, hepatitis B, in primary hepatic carcinoma, immuno-fluorescence study on fixed liver tissue, 1133

polysaccharide. See Polysaccharide antigensAntiglobulins, rheumatoid factor, in serum, direct binding

assay with fluorescein-labelled Fc fragment of humanimmunoglobulin-G, 963

Antilymphocyte globulin, crossreaction with human granulo-cyte colony-forming cells, 129

1263

1264

Antiseptics, sensitivity of urine-grown cells of Providenciastuartii to, 929

Antistreptolysin 0 activity, significance of, assessment bypolyene antibiotics, 230

s1-Antitrypsin globules in liver and PiM phenotype (P), 199API 20E system, identification of Enterobacteriaceae by, 22Apolipoprotein A, total lipids, and lipoprotein cholesterol inserum in acute viral hepatitis and chronic liver disease, 772

Arabinose, ethanol formation from, as test for E. coli, 361Association of Clinical Biochemists: Reports and Bulletins,

135, 264, 369, 453, 520, 647, 756, 826, 973, 1101Astrocytomas, grading with Quantimet 720 image-analysing

computer, 469Astrovirus associated with gastroenteritis in children, 939Atheroembolism, 984Atheroma and thrombosis, platelet function, factor Vill,

fibrinogen, and fibrinolysis in Nigerians and Europeans inrelation to, 1094

Aural and upper respiratory bacterial flora in saturationdivers, 721

Authorship, multiple, responsibility and acknowledgement in(Editorial), 299

Autoclave, laboratory, using direct air displacement by steam,sterilisation in, 144

Autoclaves, performance in microbiology laboratories,survey of, 418

Autoimmune thyroid diseases, rapid diagnosis of, evaluationof two haemagglutination tests for, 1147

Automated continuous-flow analysis of ammonia in per-chloric acid supernate of blood or plasma with ammonia-selective electrode, 1207

Bacilli, acid-fast, staining of clinical specimens for, use ofmechanical conveyor system (Cyto-Tek) for, 185

Bacteria, anaerobic, culture of, comparison of convertedpressure cookers with conventional jars for, 426

contamination of laboratory forms by (L), 1004faecal, effect of clindamycin and lincomycin therapy,

439of upper respiratory tract and ear in saturation divers,

721survival on cotton-wool swabs,

4307 isolates from diagnostic laboratory in Penang, 223skin, transient, removal by cleansing or disinfection in

relation to mode of deposition, 919Bacterial flora, effect on staphylococcal colonisation of new-

born, 153; 1254 (L); 1255 (L)meningitis, diagnosis of, comparison of latex agglutina-

tion, counterimmunoelectrophoresis, and protein Aco-agglutination in, 1167

Bacteriocin typing method for Klebsiella aerogenes, improved,evaluation and application of, 16

Bacteriology, clinical, computer system for, 1193of pilonidal cyst abscesses (L), 909reporting and information, computer system for, 673

Bacteriuria, detection by gas liquid chromatography withexamination for volatile acidic and neutral compounds, 859

Bacteroides fragilis infections, diagnosis with counter-immunoelectrophoresis, 1078

serological diagnosis by complement fixationtest, 1083

Basement membrane, antibody to, spontaneously occurring,characterisation of, 639

Basophils, histamine release reaction in chronic granulocyticleukaemia, 749

Bicarbonate solution, preparation for use in virus isolationmedia, 1112

Bile acids, serum, in hyperlipidaemia, 58y-glutamyl transferase isoenzymes in, 666

Subject index

Blood cell countingimachines. See Coulter countercells, alcohol consumption and smoking habits, 654culture media, anaerobic (L), 98donations, fresh, serum from, and selected blood

products, detection of hepatitis B surface antigen in,comparison of radioimmunoassay and enzyme immuLno-assay for, 1000

-- donors, anti-HBc positive, serological evidence ofHBsAg undetectable by conventional radioimmunoassayin, 837

? human, haemoglobinometry in, reference method for,ICSH recommendations for, 139

neutrophils, lysosomal enzyme cytochemistry of, 648or plasma, ammonia in perchloric acid supernate of,

continuous-flow analysis with ammonia-selective electrode,1207

platelet. See Plateletspecimen container leakage, analysis of, 888; 1254 (L)whole blood control for Coulter model S, 50

Body fluids, total haemolytic complement activity ill,measurement of, 527

Bone, flucloxacillin levels in hip replacement subjects, 705marrow. See MarrowPaget's disease of, osteoclast counts in, effect of

calcitonin treatment, 1212Book reviews:Abraham, G. F., ed.: Handbook of Radioinmmunoassay,

1977, 503Aherne, W. A., Camplejohn, R. S., and Wright, N. A.:An Introduction to Cell Population Kinetics, 1977, 505

Albert, K. G. M. M., ed.: Recent Advances in ClinicalBiochemistry, No. 1, 1978, 1256

Antibiotics and Chemotherapy, Vol. 22, Laboratort Testingfor Cancer, 1978, 606

Archer, R. K., and Jeffcott, L. B. eds.: ComparativeClinical Haematology, 1977, 606

Ashley, D. J. B.: Evans' Histological Appearances of'Tumours, 3rd ed., 1978, 1119

Bach, F. H., and Good, R. A., eds.: Clinical Inmuno-biology, Vol. 3, 1977, 296

Baum, S. J., and Ledney, G. D., eds.: ExperimentalHematology Today, 1977, 505

Bessis, M.: Blood Smears Reinterpreted, 1977, 912and Brecher, G., eds.: Hemopoietic Dysplasias

(Preleukemic States), 1977, 504Biggs, R., ed.: The Treatment of Haemophilia A and B and

von Willebrand's Disease, 1977, 1007Blaustein, A.: Pathology of the Female Genital Tract, 1977,

605Boorman, K. E., Dodd, B. E., and Lincoln, P. J.: Blood

Group Serology: Theory, Techniques, Practical Applica-tions, 5th ed., 1977, 297

British Association for the Advancement of Science:Salmonella-The Food Poisoner, 1978, 1007

British Medical Bulletin, Vol. 34, No. 2, Thromnbosi.s, 1978,1120

Brooke, B. N., et al.: Crohn's Disease, 1977, 912Bunn, H. F., Forget, B. G., and Ranney, H.: Human

Hemoglobins, 1977, 605Burges, S. H., ed.: The New Police Surgeon: A Practical

Guide to Clinical Forensic Medicine, 1978, 1007Carr, 1., et al.: Lymphoreticular Disease: An Introductionfor the Pathologist and Oncologist, 1977, 808

Ciba Foundation Symposium: Hepatotrophic Factors(New Series, 55), 1978, 1118

Clinics in Endocrinology and Metabolism, Vol. 7, No. 1,Thvrotoxicosis, 1978 1006

Cossart Y. E.: Virus Hepatitis and its Control, 1977, 298Crawford, Sir T.: Pathology of Ischaemic Heart Disease,

1977, 298

Subject index

CRC Handbook Series in Clinical Laboratory Science,Section D, Blood Banking, Vol. 1, 1977, 504

Current Chemotherapy: Proceedings of the 10th Inter-national Congress of Chemotherapy, 1978, 1255

Current Topics in Pathology, Vol. 63, Pathology of theGastro-intestinal Tract, ed. by B. C. Morson, 1976, 100

Dausset, J., and Svejgaard, A., eds.: HLA and Disease,1977, 910

de Voogt, H. J., Rathert, P., and Beyer-Boon, M. E.:Urinary Cytology: Phase Contrast, Microscopy andAnalysis of Stained Smears, 1977, 505

Dixon, M. F.: Aids to Pathology, 1978, 1118Dublin, W. B.: Fundamentals of Sensorineural Auditory

Pathology, 1976, 703Dubois, E. L., ed.: Lupus Erythematosus, 2nd ed., 1976, 393Dunnill, M. S.: Pathological Basis of Renal Disease, 1976,394

Essays in Medical Biochemistry, Vol. 3, 1977, 1006Evans, E. A., and Muramatsu, M., eds.: Radiotracer

Techniques and Applications, Vol. 2, 1977, 606Glynn, L. E., and Steward, M. W., eds.: Immunochemistry:An Advanced Textbook, 1977, 1256

Gompel, C., and Silverberg, S. G.: Pathology in Gynecologyand Obstetrics, 2nd ed., 1977, 504

Gray, C. H., and Howorth, P. J. N.: Clinical ChemicalPathology, 8th ed., 1977, 100

Greenwalt, T. J., and Jamieson, G. A., eds.: The Granulo-cyte: Function and Clinical Utilization (Progress inClinical and Biological Research, Vol. 13), 1977, 297

Herbert, W. J., and Wilkinson, P. C., eds.: A Dictionaryof Immunology, 2nd ed., 1977, 1007

Hobson, D., and Holmes, K. K., eds.: NongonococcalUrethritis and Related Infections, 1977, 503

Hodkinson, H. M.: Biochemical Diagnosis of the Elderly,1977, 503

Hoffbrand, A. V., Brain, M. C., and Hirsh, J., eds.: RecentAdvances in Haematology, No. 2, 1977, 297

Holt, J. G., ed.: The Shorter Bergey's Manual ofDetermina-tive Bacteriology, 8th ed., 1977, 296

Hopkins, C. R.: Structure and Function of Cells, 1978, 1119Hughes, G. R. V.: Connective Tissue Diseases, 1977, 605Hughes, J. T.: Pathology of the Spinal Cord, 2nd ed., 1978,

911Huisman, T. H. J., and Jonxis, J. H. P.: The Haemo-

globinopathies: Techniques of Identification, 1977, 296International Agency for Research on Cancer: IARCMonographs on the Evaluation of Carcinogenic Risk ofChemicals to Man, Vol. 13, Some Miscellaneous Pharma-ceutical Substances; Vol. 14, Asbestos, 1977, 200

: 1976 Annual Report, 1977,200

Kaltenbach, M., Loogen. F., and Olsen, E. G. J., eds.:Cardiomyopathy and Myocardial Biopsy, 1978, 1006

Kelly, S.: Biochemical Methods in Medical Genetics, 1977,296

Kennedy, A.: Basic Techniques in Diagnostic Histopatho-logy, 1977, 297

Laboratory and Research Methods in Biology and Medicine,Vol. 1, Practical Enzymology of the Sphingolipidoses,1978, 1117

Lancker J. L. van: Molecules, Cells, and Disease, 1977,1256

Lymphology, Vol. 10, No. 2, The Lymphoid System:Methods of Clinical Investigation, 1977, 505

Major Problems in Clinical Pediatrics, Vol. 17, ViralDiseases of the Fetus and Newborn, 1978, 1117

Major Problems in Internal Medicine, Vol. 14, The Eosino-phil, 1977, 1255

Major Problems in Pathology, Vol. 8, Use and Interpretationof Renal Biopsy, 1978, 1256

1265

Masshoff, J. W., ed.: Transplantation (Handbuch derallgemeinen Pathologie, Vol. 6, Part 8), 1977, 1255

Moragas, A., Ballabriga, A., and Vidal, M. T.: Atlas ofNeonatal Histopathology, 1978, 1120

Muir, C. S., and Wagner, G., eds: Directory of On-GoingResearch in Cancer Epidemiology, 1977, 1977, 506

Nester, E. W., et al., eds.: Microbiology, Molecules,Microbes and Man, 2nd ed., 1978, 1120

Progress in Clinical and Biological Research, Vol. 16, HLAand Malignancy, 1977, 910

Progress in Clinical Pathology, Vol. 7, 1978, 1119Raven, R. W., ed.: Principles of Surgical Oncology, 1977,912

Recent Advances in Clinical Immunology, No. 1, 1977, 1007Sandberg, L. B., Gray, W. R., and Franzblau, C., eds.:

Elastin and Elastic Tissue (Advances in ExperimentalMedicine and Biology, Vol. 79), 1977, 394

Silverberg, S. G.: Surgical Pathology of the Uterus, 1977,912

Simmons, A.: Problem Solving in Immuno-Hematology,1977, 1008

Simpson, D. I. H.: Marburg and Ebola Virus Infections,1977, 503

Smith, A., and Bruton, J.: A Colour Atlas of HistologicalStaining Techniques, 1977, 298

Spencer, H.: Pathology of the Lung, 3rd ed., 1977, 703Tedeschi, C. G., Eckert, W. G., and Tedeschi, L. G., eds.:

Forensic Medicine: A Study in Trauma and Environ-mental Hazards, 1977, 1006

Thaler, M. S., Klausner, R. D., and Cohen, H. J.: MedicalImmunology, 1977, 504

Thompson, S. W., and Luna, L. G.: An Atlas of Artifacts:Encountered in the Preparation of Microscopic TissueSections, 1978, 1119

Timbury, M. C.: Notes on Medical Virology, 6th ed., 1978,704

Treip, C. S.: A Colour Atlas of Neuropathology, 1978, 703West, J. B.: Pulmonary Pathophysiology-the Essentials,

1977, 1118Willis, A. T.: Anaerobic Bacteriology: Clinical and Labora-

tory Practice, 3rd ed., 1977, 504Willoughby, D. A., Giroud, P. J., and Velo, G. P., eds.:

Perspectives in Inflammation: Future Trends and Develop-ments, 1977, 503

Wisse, E., and Knok, D. L., eds.: Kupffer Cells and OtherLiver Sinusoidal Cells, 1977, 704

World Health Organization: Neisseria gonorrhoeae andGonococcal Infections (WHO Technical Report Series,616), 1978, 1118

Wright, R.: Immunology of Gastrointestinal and LiverDisease (Current Topics in Immunology, No. 8), 1977,505

Yardley, J. H., Morson, B. C., and Abell, M. R., eds.: TheGastrointestinal Tract, 1977, 393

Zaino, E. C., and Roberts, R. H., eds.: Chelation Therapyin Chronic Iron Overload, 1977, 1120

Books received, 1008Bowel. See Intestine(s)Breast, carcinoma of, (x-subunit HCG demonstrated byimmunoperoxidase technique in, significance of, 245

-~9, , ~~, squamous, 116Broadsheet 89 (L), 1117Bronchial carcinoid, mucin-producing, atypical, 1218__ secretions obtained at bronchoscopy, cytology of,

disposable polythene catheter as alternative to bronchialbrush for, 907

Burkitt's lymphoma, 1029Burns, severe, serum elastase and inhibitors in blood of

patients with, 866

Subject index

Calcitonin treatment, effect on osteoclast counts in Paget'sdisease of bone, 1212

Candida, humoral antibodies to, and pathogenic yeasts,prevalence in diabetics, 840

vulvovaginitis, diagnosis of (L), 98Candida albicans, antibody to, radioimmunoassay determina-

tion of levels in healthy and hospitalised adults, 1161Carbon dioxide incubator control, pH stat for, 696Carcinoembryonic antigen assay in colorectal cancer, com-

parison with pregnancy-associated a2-glycoprotein assay,1065

Carcinoid, bronchial, mucin-producing, atypical, 1218tumour of uterine cervix, 990

Carcinoma, colorectal, pregnancy-associated a2-glycoproteinand carcinoembryonic antigen assays in, comparison of,1065

hepatic, primary, hepatitis B virus antigens in, immuno-fluorescence study on fixed liver tissue, 1133

hepatocellular, and hepatic cirrhosis, 25-year necropsyreview in West of Scotland, 108

lymphocyte transformation in, variation in results withtechnique, 125

of breast, a-subunit HCG demonstrated by immuno-peroxidase technique in, significance of, 245

squamous, 116Cardiac operations with hypothermia and bypass, catechola-

mines and free fatty acids in plasma during, 949Catecholamines and free fatty acids in plasma during cardiac

operations with hypothermia and bypass, 949Catheter, polythene, disposable, as alternative to bronchial

brush for cytology of bronchial secretions obtained atbronchoscopy, 907

Cell counting in gut mucosa (L), 807- cultures as indicator of pathogenicity of free-living

amoebae, 1nomenclature in cervical cytology smears, British

Society for Clinical Cytology recommendations on, 1226receptor studies on anaplastic tumours of thyroid, 461

Cells, malignant, in sputum, detection of, mucolytic agent(Cytoclair) in preparation of cell material for, 585

Cellular constituents, immunoenzymatic labelling withalkaline phosphatase and peroxidase, 454

Cephradine and methicillin sensitivity testing of staphylo-cocci, use of polyvinylpyrrolidone in, 434

Cerebral involvement in multiple myeloma, case of, 259ventriculitis associated with Achromobacter xylos-

oxidans, 156Cerebrospinal fluid aminoglycosides, bioassay of, serum

standards for, 172and sputum, aberrant form of Ps. aeruginosa in,

infection in compromised patient due to, 351, coagulation and fibrinolytic activity of, 488in pyogenic meningitis, chemotactic activity of, 213leucocidin in pyogenic meningitis, 688protein (Broadsheet 88) (L), 1005

Cervical cytology smears, cell nomenclature in, British Societyfor Clinical Cytology recommendations on, 1226

Cervix, carcinoid tumour of, 990Chemistry, clinical. See Clinical chemistryChemotactic activity of cerebrospinal fluid in pyogenic

meningitis, 213Chest infections, detection of capsulated Haemophilus

influenzae by counter current immunoelectrophoresis in, 31Chlamydia detection in conjunctival scrapings and cell

cultures, comparison of Giemsa, immunoperoxidase andimmunofluorescence staining for, 1073

Chlamydiae in untreated and Cytochalasin B treated McCoycells, 183

Cholesterol, lipoprotein, total lipids, and apolipoprotein A

in serum in acute viral hepatitis and chronic liver disease,772

Chorionic gonadotrophin, human. See Human chorionicgonadotrophin

Chromatography, gas liquid, for detection of bacteriuria byexamination for volatile acidic and neutral compounds, 859

head-space, for detection of E. coli andProteus mirabilis in urine, 365

Cirrhosis, definition, nomenclature and classification accord-ing to morphological characteristics and aetiology, 395

, hepatic, and hepatocellular carcinoma, 25-yearnecropsy review in West of Scotland, 108

, renal failure secondary to, spectrum of renal tubulardamage in, 101

Cleansing or disinfection of transient skin flora in relation tomode of deposition, 919

Clindamycin and lincomycin therapy, effect on faecal flora,439

Clinical chemistry departments, case for laboratory aides in,136

Clostridium welchii, free-sporing, in ordinary laboratorymedia and conditions, 359

Coagglutination test for identification of clinical isolates ofNeisseria gonorrhoeae, 189

Coagulation and fibrinolytic activity of cerebrospinal fluid,488

, intravascular, disseminated, 609Colorectal cancer, pregnancy-associated cx2-glycoprotein and

carcinoembryonic antigen assays in, comparison of, 1065Compatibility testing, low ionic strength salt solution in (L),

1116Complement activity, haemolytic, total, in body fluids,measurement of, 527

and immunoglobulin in normal skin, 1143and immunoglobulins, tissue-fixed, preservation in

tissue transport-medium (Histocon) for direct immuno-fluorescence, 823

fixation test for detection of cytomegalovirus-specificserum antibodies, comparison with indirect immuno-fluorescence test for viral late antigens and anti-comple-ment immunofluorescence test, 827

in serological diagnosis of Bacteroides fragilisinfections, 1083

levels and circulating immune complexes, relation toclinical pattern of acute poststreptococcal glomerulo-nephritis in Nigerian children, 817

Computer, image-analysing, Quantimet 720, in grading ofastrocytomas, 469

system for bacteriology reporting and information, 673for clinical microbiology, 1193

Congo red and manganous chloride disc method fordifferentiation between Neisseria gonorrhoeae and N.meningitidis, 936

Conjunctival scraping and cell cultures, chlamydia detectionin, comparison of Giemsa, immunoperoxidase andimmunofluorescence staining for, 1073

Contamination, cross, of cytological smears, with automatedstaining machines and bulk manual staining procedures, 63

Copper and copper-associated protein in chronic liverdisease, histological demonstration of, 784

Corrections, 1257Corticosteroids, free, urinary excretion of, and renal function,

671Corticotrophin. See ACTHCoulter Channelyzer for abridged differential leucocyte

counts in haematology laboratory, 271counter, model S, whole blood control for, 50

Counterimmunoelectrophoresis in diagnosis of Bacteroidesfragilis infections, 1078

1266

Subject index

, latex agglutination, and protein A co-agglutination indiagnosis of bacterial meningitis, 1167

,~.) ,~and radioimmunoassay in detection ofsoluble capsular polysaccharide antigens of Haemophilusinfluenzae type B and Neisseria meningitidis groups A orC, 1172

test for detection of antibody to hepatitis B virus coreantigen, routine use of, 832

Cyst abscesses, pilonidal, bacteriology of (L), 909Cystic fibrosis, isolation of Staph. aureus from sputum in, 913Cystosarcoma phyllodes, multifocal histogenesis of, 897Cytochalasin B treated McCoy cells, isolation of Chlamydiae

in, 183Cytoclair in preparation of cell material for detection of

malignant cells in sputum, 585Cytological smears, cross contamination of, with automated

staining machines and bulk manual staining procedures, 63Cytology, imprint, in intraoperative diagnosis, value and

limitations of, 328urinary, filter imprint method for, 999

Cytomegalovirus-specific serum antibodies, detection of,comparison of complement fixation, indirect immuno-fluorescence for viral late antigens, and anti-complementimmunofluorescence tests for, 827

Cytoplasmic inclusions, unusual, in congenital dyserythro-poietic anaemia, 1228

Cytotek and Shandon Elliott staining machines, problems ofcross contamination of cytological smears, 63

-mechanical conveyor system, use for staining of clinicalspecimens for acid-fast bacilli, 185

Densitometric and immunochemical estimation of para-protein, comparison of, 1156

Diabetes, prevalence of pathogenic yeasts and humoralantibodies to candida in patients with, 840

Dialysis, peritoneal, output of peritoneal cells during, 645Diathermy, tubal, surgical sterilization by, myometrial

vascular damage after, 633Disinfection of hands, 'hygienic', test for, 923

or cleansing of transient skin flora in relation to modeof deposition, 919

Dithiothreitol for inactivation of IgM antibodies, evaluationof, 1152

in measurement of IgG anti-A/B titres, 283Divers, saturation, upper respiratory and aural bacterial

flora in, 721Duodenal and gastric mucosa, endoscopic and histopatho-

logical study in 50 'healthy' subjects, 69Duodenum, paraganglioneuroma of, ultrastructure and

evolution of, 233Dyserythropoietic anaemia, congenital, with unusual

cytoplasmic inclusions, 1228Dysfibrinogenaemia and liver cell growth, 89

e antigen, occurrence in acute hepatitis B (L), 501EB virus infection sometimes presenting as hepatitis,

laboratory diagnosis of, 179Ebola virus particles in liver, ultrastructure of, 201Echinococcus granulosus antigens, most immunoreactive

(antigens 4 and 5), in hydatid fluids, specific quantificationof, 475

Editorial: Authorships and acknowledgements, 299Elastase, serum, and inhibitors in blood of heavily burnt

patients, 866Elderly, folic acid deficiency in, early detection of, 44; 702 (L)Electrode, ammonia-selective, in continuous-flow analysis ofammonia in perchloric acid supernate of blood or plasma,1207

Electron microscopic x-ray microanalysis, identification ofthorium dioxide in liver cells by, 893

Electrophoresis, acrylamide gel gradient, in study of case oftype III hyperlipoproteinaemia, 599

Endocarditis due to Streptococcus viridans, detection ofantibodies against viridans streptococci in, immuno-fluorescent method for, 292

Endotoxin extraction from Haemophilus influenzae andpurification of specific precipitinogen, 370

nitroblue tetrazolium test stimulated by, comparativestudy in health and disease, 1249

England's discriminant function with platelet count, diagnosisof thalassaemia trait from (L), 500

Enteritis, infantile, outbreak due to enterotoxigenic E. coli06.H 16, 217

Enterobacteriaceae, identification by API 20E system, 22Enzyme immunoassay for detection of hepatitis B surface

antigen in serum from freshly donated blood and selectedblood products, comparison with radioimmunoassay, 1000

immunoassays with special reference to ELISAtechniques, 507

Erythrocyte osmotic fragility in infants, microtechnique formeasurement of, 878

sedimentation rate tubes, polystyrene (L), 295Erythrocytes, human group 0, trypsin-treated, in HAI test

for detection of rubella haemagglutination-inhibition andvirus-specific IgM antibodies, 730-. See also Red cellEscherichia coli and Proteus mirabilis, detection in urine by

head-space gas liquid chromatography, 365ethanol formation from arabinose as test for, 361resistance to aminoglycosides in, specific and

non-specific, 1206.H16, enterotoxigenic, infantile enteritis out-

break due to, 217Ethanol formation from arabinose as test for E. coli, 361

Factor VIII inhibitor bypassing activity, failure to securehaemostasis in haemophiliacs with antibodies, 1102

platelet function, fibrinogen, and fibrinolysis inNigerians and Europeans in relation to atheroma andthrombosis, 1094

Scottish, haemophiliacs on long-term therapywith, antibody to hepatitis B surface antigen in, 309

Faecal flora, effect of clindamycin and lincomycin therapy,439

Fat emulsions, intravenous, splenic lipidosis after ad-ministration of, 765

Fatty acids, free, and catecholamines in plasma duringcardiac operations with hypothermia and bypass, 949

FEIBA. See Factor VIII inhibitor bypassing activityFerritin in serum, radioimmunoassay of, 742, 872

transferrin and lactoferrin distribution in tissues, 316Fetus, second trimester, aborted, congenital syphilis in,

diagnosis by histological study, 265Fibrinogen, fibrinolysis, platelet function and factor VIII in

Nigerians and Europeans in relation to atheroma andthrombosis, 1094

Fibrinolytic activity and coagulation of cerebrospinal fluid,488

of plasma, reduced, streptokinase activated lysistime as screening test for, 54

Fibrosis, bone marrow, in acute lymphoblastic leukaemia ofchildhood, 313

cystic, isolation of Staph. aureus from sputum in, 913of mediastinum, idiopathic, 3 cases and review, 78

Flavobacterium meningosepticum, opportunistic role inimmunodeficiency, 220

Flucloxacillin in bone in hip replacement subjects, 7052,7-Fluorenediamine in myeloperoxidase cytochemistry, 1114Fluorescein-labelled Fc fragment of human immuno-

1267

1268

globulin-G in direct binding assay for rheumatoid factorserum antiglobulins, 963

Fluorescent antibody to rotavirus, method for detection of,and use in sero-epidemiology (L), 393

Fluorimetric assay of mycobacterial group-specific hydrolaseenzymes, 378

Folate binding protein, specific and non-specific, in normaland malignant tissues, 659

deficiency and vitamin B12 deficiency, haemoglobin A2levels in, 960-, early detection in elderly, 44; 702 (L)serum, assay with Lactobacillus casei, effect of Tween 80

on incubation period of, 227Food as source of Klebsiella species colonisation and

infection of intensive care patients, 845

Gas liquid chromatography for detection of bacteriuria byexamination for volatile acidic and neutral compounds, 859

head-space, for detection of E. coli andProteus mirabilis in urine, 365

Gastric and duodenal mucosa, endoscopic and histopatho-logical study in 50 'healthy' subjects, 69

parietal cells, actin and microsomal antigen in,ontogeny of, 578

Gastroenteritis associated with astrovirus in children, 939Gastrointestinal mucosa, cell counting in (L), 807Gaucher's disease, diagnosis with artificial substrates,

limitations of, 1091Germinoblastoma, 1024Germinocytoma, 1022Giardiasis, quantitative histology in, 712Giemsa staining for detection of chlamydia in conjunctival

scrapings and cell cultures, comparison with immuno-peroxidase and immunofluorescence staining, 1073

Globulin, antilymphocyte, crossreaction with humangranulocyte colony-forming cells, 129

Glomerular capsular space, Tamm-Horsfall protein in, 620disease, IgA localisation in (L), 502

Glomerulonephritis, poststreptococcal, acute, relation ofcirculating immune complexes and complement levels toclinical pattern in Nigerian children with, 817

y-Glutamyl transferase isoenzymes in bile, 666a2-Glycoprotein, pregnancy-associated, assay in colorectal

cancer, comparison with carcinoembryonic antigen assay,1065

Glycosaminoglycans, urinary excretion in disseminatedneoplasm, 447

Grafts, marrow, rejection of, and inhibition of growth inculture by serum in aplastic anaemia, 1244

Granulocyte colony-forming cells, human, crossreaction ofantilymphocyte globulin with, 129

membrane, lazy leucocyte syndrome as disorder of, 300Granulocytic leukaemia, chronic, histamine release reaction

of basophils in, 749Grocott's methenamine silver nitrate method for staining of

Pneumocystis carinfl, modification of, 803Guanosine 3',5'-monophosphate and adenosine 3',5'-mono-

phosphate, cyclic, urinary excretion in malignancy, 735

Haemagglutination inhibition and virus-specific IgM anti-bodies, rubella, detection by HAI test with trypsin-treatedhuman group 0 erythrocytes, 730

in estimation of rubella antibody, comparison withradial haemolysis, 479

tests, two, for rapid diagnosis of autoimmune thyroiddiseases, evaluation of, 1147

Haemangioendothelioma with myelofibrosis, splenic atrophy,and myeloma paraproteinaemia after parenteral thorotrastadministration, 1125

Subject index

Haematology, ICSH protocol for type testing equipment andapparatus used for haematological analysis, 275

Haematoxylin and eosin stain for histological sections oflymph nodes, 700-, anthocyanin BB as nuclear stain substitute for, 194Haemiglobincyanide reference preparation, international,ICSH specifications for, 141

Haemoglobin A2 levels in vitamin B12 and folate deficiency,960

variant, unstable-Hb Tacoma /30 (B12) arg--ser-detected at birth by demonstration of red cell inclusions,883

Haemoglobinometry in human blood, reference method for,ICSH recommendations for, 139

Haemolysis, radial, in detection of rubella antibody, assess-ment of, 35-, ~~, in estimation of rubella antibody, comparison

with haemagglutination inhibition, 479, single radial haemolysis technique for rubella antibody

measurement, evaluation of, 521Haemolytic complement activity, total, in body fluids,measurement of, 527

Haemophilia A patients on long-term therapy with Scottishfactor VIII, antibody to hepatitis B surface antigen in, 309

liver disease in, clinicopathological study of, 779patients with factor VIII antibodies, failure of FEIBA

to secure haemostasis in, 1102Haemophilus influenza, capsulated, detection in chest

infections by counter current immunoelectrophoresis, 31~ , purification of specific precipitinogen and

extraction of endotoxin from, 370type B and Neisseria meningitidis groups A or C,

soluble capsular polysaccharide antigens of, detection of,comparison of counterimmunoelectrophoresis, latex agglu-tination, and radioimmunoassay for, 1172

Haemorrhoids and internal sphincter, pathological study of,268

Haemostasis, failure of FEIBA to secure, in haemophiliacswith antibodies, 1102

Hairy cell leukaemia, 1019Hand disinfection, 'hygienic', test for, 923Heart involvement, myotonia dystrophica with, electron

microscopic study of skeletal, cardiac, and smooth musclein, 1057

Heavy chain diseases, 1035Hepatic carcinoma, primary, hepatitis B virus antigens in,

immunofluorescence study on fixed liver tissue, 1133- cirrhosis and hepatocellular carcinoma, 25-year

necropsy review in West of Scotland, 108failure, fulminant, renal failure secondary to, spectrum

of renal tubular damage in, 101Hepatitis, acute, significance of antibody to hepatitis B core

antigen in, 1140B, acute, occurrence of e antigen in (L), 501-antigens in primary hepatic carcinoma, immuno-

fluorescence study on fixed liver tissue, 1133core antigen, antibody to, detection of, routine use

of counterimmunoelectrophoresis for, 832infection, viral antigens and antibodies in, 681surface antigen, antibody to, in haemophiliacs on

long-term therapy with Scottish factor VIII, 309detection in serum from freshly donated

blood and selected blood products, comparison of radio-immunoassay and enzyme immunoassay for, 1000

, mass screening of serum samples for,multiple sampling device for, 288

undetectable by conventional radio-immunoassay in anti-HBc positive blood donors, sero-logical evidence of, 837

Subject index

EB virus infection presenting as, laboratory diagnosisof, 179

in clinical laboratories, survey of (1975-76), 415viral, acute, and chronic liver disease, serum total

lipids, lipoprotein cholesterol, and apolipoprotein A in, 772Hepatocellular carcinoma and hepatic cirrhosis, 25-year

necropsy review in West of Scotland, 108Hip replacement subjects, flucloxacillin in bone in, 705Histamine release reaction of basophils in chronic granulo-

cytic leukaemia, 749Histiocytic disorders, 1041

variant of lymphocytic predominance subtype ofHodgkin's disease, differential cell counts in, 1234

Histiocytosis, malignant, 1043Histocon in preservation of tissue-fixed immunoglobulins andcomplement for direct immunofluorescence, 823

Histopathology, diagnostic, referrals for second opinion in,1121

, technical quality control in, 996Hodgkin's disease, diffuse, histological typing of, cytological

basis of, 551, lymphocytic predominance subtype of, histiocytic

variant of, differential cell count in, 1234Human chorionic gonadotrophin, a-subunit of, demonstrated

in breast carcinomas by immunoperoxidase technique,significance of, 245

Hydatid fluids, most immunoreactive Echinococcus granulosusantigens (4 and 5) in, specific quantification of, 475

Hydrogen ion concentration. See pHHydrolase enzymes, group-specific, mycobacterial, fluori-

metric assay of, 378Hyperlipidaemia, serum bile acids in, 58Hyperlipoproteinaemia, type Ill, study of case by acrylamide

gel gradient electrophoresis, 599Hypochlorite and alcohol mixtures, sporicidal activity of, 148Hypothermia and bypass, cardiac operations with, catechol-

amines and free fatty acids in plasma during, 949Hypoxic changes in pulmonary arterioles and arteries insudden infant death syndrome (L), 198

Immune complexes, circulating, and complement levels,relation to clinical pattern of acute poststreptococcalglomerulonephritis in Nigerian children, 817

Immunoassay(s), enzyme. See Enzyme immunoassay(s)Immunoblastic malignant lymphoma, 1036Immunochemical and densitometric estimation of para-

protein, comparison of, 1156Immunocytoma, IgM lambda cytoplasmic crystals in 3 cases

of, clinical, cytochemical and ultrastructural study of, 250Immunodeficiency, opportunistic role of Flavobacterium

meningosepticum in, 220Immunoelectrophoresis, counter current, detection of

capsulated Haemophilus influenzae in chest infections by, 31Immunoenzymatic labelling of cellular constituents with

alkaline phosphatase and peroxidase, 454Immunofluorescence and immunoperoxidase techniques in

demonstration of immunoglobulin in cryostat and paraffinsections of tonsil, 974; Erratum, 1257

direct, tissue transport-medium (Histocon) in preserva-tion of tissue-fixed immunoglobulins and complement for,823

microscopy, small quartz halogen lamps for, 1253staining for detection of chlamydia in conjunctival

scrapings and cell cultures, comparison with Giemsa andimmunoperoxidase staining, 1073

- study of hepatitis B virus antigens in primary hepaticcarcinoma on fixed liver tissue, 1133

test, indirect, for viral late antigens for detection ofcytomegalovirus-specific serum antibodies, comparison

with complement fixation and anti-complement immuno-fluorescence tests, 827

Immunofluorescent method for detection of antibodiesagainst viridans streptococci in Streptococcus viridansendocarditis, 292

Immunoglobulin A localisation in glomerular disease (L), 502and complement in normal skin, 1143G anti-A/B titres, dithiothreitol in measurement of, 283

, human, Fc fragment of, fluorescein-labe!led, indirect binding assay for rheumatoid factor serum anti-globulins, 963

in cryostat and paraffin sections of tonsil, demonstrationby immunofluorescence and immunoperoxidase techniques.974; Erratum, 1257

M antibodies, dithiothreitol for inactivation of,evaluation of, 1152

rubella-specific, solid-phase radioimmuno-assay of, interference of IgM-class rheumatoid factor in,483

lambda cytoplasmic crystals in 3 cases of immuno-cytoma, clinical, cytochemical and ultrastructural study of,250

-~ ~~, virus-specific, and haemagglutination-inhibitionantibodies, rubella, detection by HAI test with trypsin-treated human group 0 erythrocytes, 730

Immunoglobulins and complement, tissue-fixed, preservationin tissue transport-medium (Histocon) for direct immuno-fluorescence, 823

, serum levels before and after splenectomy in homo-zygous ,-thalassaemia, 546

Immunoperoxidase and immunofluorescence techniques indemonstration of immunoglobulin in cryostat and paraffinsections of tonsil, 974; Erratum, 1257

procedures, non-carcinogenic substrate for (L), 701staining for detection of chlamydia in conjunctival

scrapings and cell cultures, comparison with Giemsa andimmunofluorescence staining, 1073

technique, n-subunit HCG demonstrated in breastcarcinomas by, significance of, 245

Imprint cytology in intraoperative diagnosis, value andlimitations of, 328

Infant death syndrome. See Sudden infant death syndromeIntensive care patients, Klebsiella species colonisation and

infection of, food as source of, 845Intestines, carriage of group D streptococci in, 1182

, inflammatory disease of, non-specific, overlappingpathology in 'colitis indeterminate' cases, 567

,9 ,serum lysozyme activity and thermo-lability in, 39

Intracranial tumours, remote metastases from, 794Intravascular coagulation, disseminated, 609Iron content of nails and assessment of body iron, 1068Isoniazid, ingestion of, sensitive urine test for monitoring of

(L), 97

Klebsiella species colonisation and infection of intensive carepatients, food as source of, 845

Klebsiella aerogenes, bacteriocin typing method for, improved,evaluation and application of, 16

Kupffer cell angiosarcoma. See Haemangioendothelioma

Laboratories, clinical, hepatitis in, survey of (1975-76), 415,microbiology, autoclaving practice in, survey of, 418

Laboratory aides in district clinical chemistry departments,case for, 136

apparatus, historic, preservation of (L), 808autoclave using direct air displacement by steam.

sterilisation in, 144forms, bacterial contamination of (L), 1004

1269

Subject index

Lactobacillus casei assay of serum folate, effect of Tween 80on incubation period of, 227

Lactoferrin, transferrin and ferritin distribution in tissues, 316Lamps, halogen, quartz, small, for immunofluorescence

microscopy, 1253Latex agglutination, counterimmunoelectrophoresis, and

protein A co-agglutination in diagnosis of bacterialmeningitis, 1167

and radioimmunoassay in detection ofsoluble capsular polysaccharide antigens of Haemophilusinfluenzae type B and Neisseria meningitidis groups A or C,1172

Legionnaires' disease agent, pneumonic illnesses acquired inSpain due to, pathology of 5 Scottish deaths from, 809

Lennert's lymphoma, case of, 560Leucocidin in cerebrospinal fluid in pyogenic meningitis, 688Leucocyte counts, differential, abridged, with Coulter

Channelyzer in haematology laboratory, 271Leucocytes, lazy leucocyte syndrome as disorder of granulo-

cyte membrane, 300, polymorphonuclear and mononuclear, phagocytosis

and killing of staphylococci by, 539Leukaemia, granulocytic, chronic, histamine release reaction

of basophils in, 749hairy cell, 1019lymphoblastic, acute, 1039

,~9 ~, in childhood, bone marrow fibrosis in, 313lymphocytic, chronic, 1010prolymphocytic, 1016

Lincomycin and clindamycin therapy, effect on faecal flora,439

Lipidosis, splenic, after administration of intravenous fatemulsions, 765

Lipids, total, lipoprotein cholesterol, and apolipoprotein Ain serum in acute viral hepatitis and chronic liver disease,772

Lipoproteins in abetalipoproteinaemic plasma, chemical andkinetic study of, 382

Liver and pancreas in acute necrotising pancreatitis, 791as-antitrypsin in, and PiM phenotype (L), 199cell growth and dysfibrinogenaemia, 89cells, thorium dioxide in, identification by electron

microscopic x-ray microanalysis, 893disease, chronic, and acute viral hepatitis, serum total

lipids, lipoprotein cholesterol, and apolipoprotein A in, 772copper and copper-associated protein in,

histological demonstration of, 784in haemophiliacs, clinicopathological study of, 779

Ebola virus particles in, ultrastructure of, 201Low ionic strength salt solution in compatibility testing, (L)

1116Lymph node cell counts, differential. in histiocytic variant of

lymphocytic predominance subtype of Hodgkin's disease.1234

hyperplasia, giant, of mediastinum and refractoryanaemia, 757

nodes, histological sections of, haematoxylin and eosinstain for, 700

Lymphatic cells and derived tumours, morphology of, 1009Lymphoblastic leukaemia, acute, 1039

9 , in childhood, bone marrow fibrosis in, 313Lymphocyte transformation in cancer, variation in results

with technique, 125Lymphocytic leukaemia, chronic, 1010Lymphoma, Burkitt's, 1029

Lennert's, case of, 560malignant, centroblastic-centrocytic, 1024

centrocytic, 1022immunoblastic, 1036lymphoblastic, of convoluted cell type, 1037

, lymphocytic, 1010, lymphoplasmacytoid, 1032of germinal centre cell origin, 1020of immunoglobulin-secreting cells and lympho-

plasmacytic dyscrasias, 1032plasmacytic, 1035T-zone, 1015

Lysis time, streptokinase activated, as screening test forreduced fibrinolytic activity of plasma, 54

Lysosomal enzyme cytochemistry of blood neutrophils, 648Lysozyme, serum, activity and thermolability in inflammatorybowel disease, 39

McCoy cells, untreated and treated with Cytochalasin B,isolation of Chlamydiae in, 183

Malignancy, urinary excretion of cyclic adenosine 3',5'-monophosphate and cyclic guanosine 3',5'-monophosphatein, 735

Malignant cells in sputum, detection of, mucolytic agent(Cytoclair) in preparation of cell material for, 585

-tissues, specific and non-specific folate binding proteinin, 659

Manganous chloride and Congo red disc method fordifferentiation between Neisseria gonorrhoeae and N.meningitidis, 936

Marrow cellularity, assessment by point-counting method,753

fibrosis in acute lymphoblastic leukaemia of childhood,313

graft rejection and inhibition of growth in culture byserum in aplastic anaemia, 1244

granulocyte colony-forming cells, human, cross-reaction of antilymphocyte globulin with, 129

Mediastinum, giant lymph node hyperplasia of, and refrac-tory anaemia, 757

, idiopathic fibrosis of, 3 cases and review, 78Meningitis, bacterial, diagnosis of, comparison of latex

agglutination, counterimmunoelectrophoresis, and proteinA co-agglutination in, 1167

, pyogenic, cerebrospinal fluid in, chemotactic activityof, 213

,~9 , ~ ~ leucocidin in, 688Meningococcal infection and proteolytic control, 1177Meningoencephalitis, amoebic, Acanthamoeba culbertsoni in

case of, retrospective identification of, 717Methenamine silver nitrate method, Grocott's, for staining

of Pneumocystis carinii, modification of, 803Methicillin and cephradine sensitivity testing of staphylo-

cocci, use of polyvinylpyrrolidone in, 434Methylumbelliferyl and other substrates for diagnosis of

Gaucher's disease, limitations of, 1091Metronidazole 'resistance', incomplete anaerobiosis as cause

of, 933Microbiology. See BacteriologyMicrocult system for isolation and identification of Neisseriagonorrhoeae, evaluation of, 209

Mucin, atypical bronchial carcinoid producing, 1218Mucolytic agent (Cytoclair) in preparation of cell material

for detection of malignant cells in sputum, 585Mucosa, gastric and duodenal, endoscopic and histopatho-

logical study in 50 'healthy' subjects, 69, gastrointestinal, cell counting in (L), 807

Muscle changes in pulmonary arterioles and arteries insudden infant death syndrome (L), 198

, skeletal, cardiac, and smooth, in myotonia dystrophicawith heart involvement, electron microscopic study of, 1057

Mycobacterial group-specific hydrolase enzymes, fluori-metric assay of, 378

Mycosis fungoides and Sezary syndrome, 1016Myelofibrosis, splenic atrophy, and myeloma paraprotein-

1270

Subject index

aemia associated with haemangioendothelioma afterparenteral thorotrast administration, 1125

Myeloma, multiple, cerebral involvement in, case of, 259Myeloperoxidase cytochemistry with 2,7-fluorenediamine,

1114Myometrial vascular damage after surgical sterilisation by

tubal diathermy, 633Myotonia dystrophica with heart involvement, electron

microscopic study of skeletal, cardiac, and smooth musclein, 1057

Nails, iron content, and assessment of body iron, 1068Nalidixic acid strip method in preliminary identification of

non-sporing anaerobes, 806Neisseria gonorrhoeae and N. meningitidis, differentiation

between, manganous chloride and Congo red disc methodfor, 936

clinical isolates of, identification by co-agglutina-tion test, 189

colonial type 5, pathogenicity of, 437Microcult system for isolation and identification

of, evaluation of, 209meningitidis, comparative susceptibility to sodium

sulphadiazine and sodium fusidate in vitro, 355groups A or C and Haemophilus influenzae type B,

soluble capsular polysaccharide antigens of, detection of,comparison of counterimmunoelectrophoresis, latex ag-glutination, and radioimmunoassay for, 1172

Neoplasm, disseminated, urinary glycosaminoglycan excre-tion in, 447

Neurosurgical operations, infections after, propionibacteriaas cause of, 1085

Neutrophils of blood, lysosomal enzyme cytochemistry of,648

Newborn, staphylococcal colonisation of, effect of bacterialflora, 153; 1254 (L); 1255 (L)

Nigerian children with acute poststreptococcal glomerulo-nephritis, relation of circulating immune complexes andcomplement levels to clinical pattern in, 817

Nigerians and Europeans, platelet function, factor VIII,fibrinogen, and fibrinolysis in relation to atheroma andthrombosis in, 1094

Nitroblue tetrazolium test, endotoxin-stimulated, compara-tive study in health and disease, 1249

Notices, 298, 1008, 1257

Oesophageal papillomatosis, benign, case report and reviewof literature, 111

Paget's disease of bone, oesteoclast counts in, effect ofcalcitonin treatment, 1212

Pancreatitis, necrotising, acute, liver and pancreas in, 791Paper-strip method for detection of penicillinase productionby penicillin resistant strains of Staphylococcus aureus, 388

Papillomatosis, oesophageal, benign, case report and reviewof literature, 111

Paraffin, liquid, in preservation of pathological specimens,499

Paraganglioneuroma of duodenum, ultrastructure andevolution of, 233

Paraprotein estimation, immunochemical and densitometric,comparison of, 1156

Paraproteinaemia, myeloma, myelofibrosis, and splenicatrophy associated with haemangioendothelioma afterparenteral thorotrast administration, 1125

Parathyroid glands, adenomatous and hyperplastic, histo-logical comparison of, 626; 1254 (L)

Parietal cells, gastric, actin and microsomal antigen in,ontogeny of, 578

1271

Pathological specimens, preservation of, use of liquidparaffin for, 499

Penang, 7 bacterial isolates from diagnostic laboratory in, 223Penicillinase production by penicillin resistant strains of

Staphylococcus aureus, paper-strip method for detection of,388

Peritoneal dialysis, output of peritoneal cells during, 645Peroxidase and alkaline phosphatase for immunoenzymatic

labelling of cellular constituents, 454pH stat for carbon dioxide incubator control, 696Phagocytosis and killing of staphylococci by polymorpho-

nuclear and mononuclear leucocytes, 539Phenytoin sodium, pseudolymphomatous reaction in soft

tissue associated with, 761Pilonidal cyst abscesses, bacteriology of (L), 909PiM phenotype and cxq-antitrypsin in liver (P), 199Plasma, abetalipoproteinaemic, lipoproteins in, chemical and

kinetic study of, 382alkaline phosphatase (EC 3.1.3.1) activity in adult

population of Scottish new town (Cumbernauld), frequencydistribution and 'reference values' of, 1202

catecholamine and free fatty acid levels during cardiacoperations with hypothermia and bypass, 949

exchange, method for, 1111fibrinolytic activity, reduced, streptokinase activated

lysis time as screening test for, 54or blood, ammonia in perchloric acid supernate of,

continuous-flow analysis with ammonia-selective electrode,1207- viscosity as routine laboratory test (L), 293

volume measurement with ""Fe-labelled transferrin, 196Plasmacytic malignant lymphoma, 1035Platelet aggregation in chronic idiopathic thromocytopenic

purpura, 1239count and England's discriminant function, diagnosis

of thalassaemia trait from (L), 500counting with Technicon Autocounter, improved

methods for, 390function, factor VIII, fibrinogen, and fibrinolysis in

Nigerians and Europeans in relation to atheroma andthrombosis, 1094

Pneumocystis carinii, staining of, modified Grocott'smethenamine silver nitrate method for, 803

Pneumonic illnesses acquired in Spain due to Legionnaires'disease agent, pathology of 5 Scottish deaths from, 809

Point-counting method for assessment of bone marrowcellularity, 753

Polycythaemia, diagnosis of, method for, 956Polyene antibiotics in assessment of significance of anti-

streptolysin 0 activity, 230Polyomavirus (BK), human, infection with, and ureteric

stenosis, in renal allograft recipients, 338Polysaccharide antigens, capsular, soluble, of Haernophilus

influenzae type B and Neisseria meningitidis groups A or C,detection of, comparison of counterimmunoelectro-phoresis, latex agglutination, and radioimmunoassay for,1172

Polystyrene ESR tubes (L), 295Polyvinylpyrrolidone in testing ofstaphylococci for sensitivity

to methicillin and cephradine, 434Pregnancy-associated a2-glycoprotein assay in colorectal

cancer, comparison with carcinoembryonic antigen assay,1065

Pressure cookers, converted, for anaerobic bacterial culture,comparison with conventional jars, 426

Prolymphocytic leukaemia, 1016Propionibacteria as cause of shunt and postneurosurgical

infections, 1085Protein A co-agglutination, latex agglutination, and counter-

1272

immunoelectrophoresis in diagnosis of bacterial meningitis,1167

cerebrospinal fluid (Broadsheet 88) (L), 1005copper-associated, and copper in chronic liver disease,

histological demonstration of, 784, Tamm-Horsfall, in glomerular capsular space, 620

Proteolytic control and meningococcal infection, 1177Proteus mirabilis and E. coli, detection in urine by head-space

gas liquid chromatography, 365Providencia stuartii cells grown in urine, sensitivity to

antiseptics, 929Pseudolymphomatous reaction in soft tissue associated with

phenytoin sodium, 761Pseudomonas aeruginosa, aberrant form of, in sputum and

CSF, infection in compromised patient due to, 351Pulmonary arterioles and arteries, muscle changes in sudden

infant death syndrome in (L), 198Pus, sulphonamide-trimethoprim synergy in presence of,

162; 700 (L)Pyogenic meningitis, cerebrospinal fluid in, chemotactic

activity of, 213leucocidin in, 688

Pyruvate fermentation test in differentiation of group Dstreptococci, comparison with tetrazolium reduction, 692

Quality control, technical, in histopathology, 996Quantimet 702 image-analysing computer in grading of

astrocytomas, 469

Radial haemolysis in detection of rubella antibody, assess-

ment of, 35in estimation of rubella antibody, comparison with

haemagglutination inhibition, 479~~ technique, single, for rubella antibody measure-

ment, evaluation of, 521Radioassay, 75Se-selenofolate, measurement of red cell

folate with, 47Radioimmunoassay, counterimmunoelectrophoresis, and

latex agglutination in detection of soluble capsular poly-saccharide antigens of Haemop/iilus influenzae type B andNeisseria meningitidis groups A or C, 1172

determination of levels of Candida albicans in healthyand hospitalised adults, 1161

- for detection of hepatitis B surface antigen in serum

from freshly donated blood and selected blood products,comparison with enzyme immunoassay, 1000

of serum ferritin, 742, 872solid-phase, of rubella-specific IgM antibodies,

interference of IgM-class rheumatoid factor in, 483Red cell folate, measurement with 75Se-selenofolate radio-

assay, 47- inclusions, unstable haemoglobin-Hb Tacoma

/30 (B 12) arg-*ser-detected at birth by demonstration of,883

mass, prediction from weight and height, nomo-

gram for, 1003volume, mean, high, incidence and significance in

routine haematology, 493cell(s). See also Erythrocyte(s)

Renal allograft recipients, human polyomavirus (BK)infection and ureteric stenosis in, 338

failure secondary to cirrhosis or fulminant hepaticfailure, spectrum of renal tubular damage in, 101

function and urinary free corticosteroid excretion, 671Respiratory tract, upper, and ear, bacterial flora of, in

saturation divers, 721bacteria of, survival on cotton-wool swabs,

430R-factor mediated trimethoprim resistance, two 3-month

clinical surveys of, 850

Subject index

Rheumatoid factor, IgM-class, interference in solid-phaseradioimmunoassay of rubella-specific IgM antibodies, 483

serum antiglobulins, direct binding assay withfluorescein-labelled Fc fragment of human immuno-globulin-G, 963

Ristocetin and thrombin clotting time, 1106Romanowsky stain, standardised, staining properties and

stability of, 280Rotavirus, fluorescent antibody to, method for detection of,and use in sero-epidemiology (L), 393

Rotaviruses in stools, diagnosis of, 175Rubella antibody estimation, comparison of radial haemo-

lysis with haemagglutination inhibition in, 479-measurement by single radial haemolysis technique,

evaluation of, 521, radial haemolysis in detection of, assessment of, 35

haemagglutination-inhibition and virus-specific 1gMantibodies, detection by HAI test with trypsin-treatedhuman group 0 erythrocytes, 730

-specific IgM antibodies, solid-phase radioimmunoassayof, interference of IgM-class rheumatoid factor in, 483

Salmonella isolation with standardised inoculum and rotaryplating technique, 904

Salt solution, low ionic strength, in compatibility testing(L), 1116

75Se-Selenofolate radioassay measurement of red cell folate,47

Sensititre system for determination of antibiotic sensitivities,531, 536

Sero-epidemiology, use of method for detection of fluorescentantibody to rotavirus in (L), 393

Serological evidence of HBsAg undetectable by conventionalradioimmunoassay in anti-HBc positive blood donors, 837

Serum antibodies, cytomegalovirus-specific, detection of,comparison of complement fixation, indirect immuno-fluorescence for viral late antigens, and anti-complementimmunofluorescence tests for, 827

bile acids in hyperlipidaemia, 58elastase and inhibitors in blood of heavily burnt patients,

866ferritin, radioimmunoassay of, 742, 872folate Lactobacillus casei assay, effect of Tween 80 on

incubation period of, 227from freshly donated blood and selected blood products,

hepatitis B surface antigen detection in, comparison ofradioimmunoassay and enzyme immunoassay for, 1000

immunoglobulin levels before and after splenectomy inhomozygous f-thalassaemia, 546

inhibition of marrow culture growth and marrow graftrejection in aplastic anaemia, 1244

lysozyme activity and thermolability in inflammatorybowel disease, 39

rheumatoid factor antiglobulins, direct binding assaywith fluorescein-labelled Fc fragment of human immuno-globulin-G, 963

samples, mass screening for HBsAg of, multiplesampling device for, 288

standards for bioassay of aminoglycosides in cerebro-spinal fluid, 172

total lipids, lipoprotein cholesterol, and apolipoproteinA in acute viral hepatitis and chronic liver disease, 772

Sezary syndrome and mycosis fungoides, 1016, small-cell, with null-cell features, case of (L), 501

Shandon Elliott and Cytotek staining machines, problems ofcross contamination of cytological smears, 63

Shunt and postneurosurgical infections, propionibacteria ascause of, 1085

Skin flora, transient, removal by cleansing or disinfection inrelation to mode of deposition, 919

Subject index

normal, immunoglobulin and complement in, 1143patients, Staph. aureus in, acquisition of antibiotic

resistance by, 1187Smoking habits, blood cells and alcohol consumption, 654Sodium sulphadiazine and sodium fusidate, comparative

susceptibility of Neisseria meningitidis in vitro to, 355Spain, pneumonic illnesses due to Legionnaires' disease agent

acquired in, pathology of 5 Scottish deaths from, 809Sphincter, internal, and haemorrhoids, pathological study of,

268Spleen, atrophy of, myelofibrosis, and myeloma paraprotein-

aemia associated with haemangioendothelioma afterparenteral thorotrast administration, 1125

, lipidosis of, after administration of intravenous fatemulsions, 765

Splenectomy in homozygous fl-thalassaemia, serum immuno-globulin levels before and after, 546

Spores, quantitative recovery from thermophilic spore papers,423

Sporicidal activity of alcohol and hypochlorite mixtures, 148Sputum and CSF, aberrant form of Ps. aeruginosa in,

infection in compromised patient due to, 351laboratory examination of, evaluation of methods, 724malignant cells in, detection of, mucolytic agent

(Cytoclair) in preparation of cell material for, 585, Staph. aureus isolation from, in cystic fibrosis, 913

Squamous carcinoma of breast, 116Staining machines, automated, and bulk manual staining

procedures, problems ofcross contamination of cytologicalsmears, 63

nuclear, anthocyanin BB as substitute for haematoxylinin, 194

of clinical specimens for acid-fast bacilli using mech-anical conveyor system (Cyto-Tek), 185

Stains, Romanowsky, standardised, staining properties andstability of, 280

Staphylococcal colonisation of newborn, effect of bacterialflora, 153; 1254 (L); 1255 (L)

Staphylococci, phagocytosis and killing of, by polymorpho-nuclear and mononuclear leucocytes, 539

testing for sensitivity to methicillin and cephradine, useof polyvinylpyrrolidone in, 434

Staphylococcus aureus in skin patients, acquisition of anti-biotic resistance by, 1187

isolation from sputum in cystic fibrosis, 913penicillin resistant strains, penicillinase production

by, paper-strip method for detection of, 388saprophyticus infection of urinary tract in young

women, 348Sterilisation in laboratory autoclave using direct air displace-ment by steam, 144

, surgical, by tubal diathermy, myometrial vasculardamage after, 633

Stools, rotaviruses in, diagnosis of, 175Streptococci group D, carriage in bowel, 1182

differentiation of, pyruvate fermentationtest in comparison with tetrazolium reduction for, 692

Streptococcus viridans endocarditis, detection of antibodiesagainst viridans streptococci in, immunofluorescentmethod for, 292

Streptokinase activated lysis time as screening test for reducedfibrinolytic activity of plasma, 54

Substrates, artificial, for diagnosis of Gaucher's disease,limitations of, 1091

Sudden infant death syndrome, muscle changes in pulmonaryarterioles and arteries in (L), 198

Sulphamethoxazole and trimethoprim activity, effect ofthymidine, 165

Sulphonamide and trimethoprim, synergy between, inpresence of pus, 162; 700 (L)

1273

Syphilis, congenital, in aborted second trimester fetus,diagnosis by histological study, 265

Tamm-Horsfall protein in glomerular capsular space, 620Technicon Autocounter, platelet counting with, improvedmethods for, 390

Tetrazolium reduction test in differentiation of group Dstreptococci, comparison with pyruvate fermentation, 692

Thalassaemia trait, diagnosis from platelet count andEngland's discriminant function (L), 500

f-Thalassaemia, homozygous, serum immunoglobulin levelsbefore and after splenectomy in, 546

Thorium dioxide in liver cells, identification by electronmicroscopic x-ray microanalysis, 893

Thorotrast administration, parenteral, haemangioendo-thelioma with myelofibrosis, splenic atrophy, and myelomaparaproteinaemia after, 1125

Thrombin clotting time and ristocetin, 1106Thrombocytopenic purpura, idiopathic, chronic, platelet

aggregation in, 1239Thrombosis and atheroma, platelet function, factor VIII,

fibrinogen, and fibrinolysis in Nigerians and Europeans inrelation to, 1094

Thymidine, effect on trimethoprim and sulphamethoxazoleactivity, 165

mutants (L), 808Thyroid diseases, autoimmune, rapid diagnosis of, evaluation

of two haemagglutination tests for, 1147, tumours of, anaplastic, cell receptor studies on, 461

Tissue transport-medium (Histocon) in preservation oftissue-fixed immunoglobulins and complement for directimmunofluorescence, 823

Tonsil, immunoglobulin in cryostat and paraffin sections of,demonstration by immunofluorescence and immuno-peroxidase techniques, 974; Erratum, 1257

Transferrin, 5Fe-labelled, in measurement of plasma volume,196

, ferritin and lactoferrin distribution in tissues, 316Trimethoprim and sulphamethoxazole activity, effect of

thymidine, 165and sulphonamide, synergy between, in presence of pus,

162; 700 (L)resistance mediated by R-factor, two 3-month clinical

surveys of, 850Trypsin-treated human group 0 erythrocytes in HAI test for

detection of rubella haemagglutination-inhibition andvirus-specific IgM antibodies, 730

Tubal diathermy, surgical sterilisation by, myometrialvascular damage after, 633

Tumour, carcinoid, of uterine cervix, 990Tumours derived from lymphatic cells, morphology of, 1009

intracranial, remote metastases from, 794of thyroid, anaplastic, cell receptor studies on, 461

Tween 80, effect on incubation period of Lactobacillus caseiassay of serum folate, 227

Umbilical cord, appearance at birth and water content,studies of, 944

Ureter, stenosis of, and human polyomavirus (BK) infectionin renal allograft recipients, 338

Uric acid assay, automated, 93Urinary cytology, filter imprint method for, 999

excretion of cyclic adenosine 3',5'-monophosphate andcyclic guanosine 3',5'-monophosphate in malignancy, 735

free corticosteroid excretion and renal function, 671glycosaminoglycan excretion in disseminated neoplasm,

447tract infection, urine xanthine oxidase activity in, 444

with Staphylococcus saprophyticus, etc., inyoung women, 348

1274 Subject index

Urine, Providencia stuartii cells grown in, sensitivity to for use in, 1112antiseptics, 929 Vitamin B12 and folate deficiency, haemoglobin A2 levels in,

test, sensitive, for monitoring ingestion of isoniazid (L), 96097

Water content and appearance at birth of umbilical cord,Ventriculitis, cerebral, associated with Achromobacter studies of, 944

xylosoxidans, 156Viral antigens and antibodies in hepatitis B infection, 681 Xanthine oxidase activity in urine in urinary tract infection,

hepatitis, acute, and chronic liver disease, serum total 444lipids, lipoprotein cholesterol, and apolipoprotein A in, 772

transport media, comparison of (L), 500 Yeasts, pathogenic, and humoral antibodies to candida,Virus isolation media, preparation of bicarbonate solution prevalence in diabetics, 840

Broadsheets prepared by the Association ofClinical Pathologists31 Investigation of hemorrhagic stateswith special reference to defects ofcoagulation of the blood 1961(Revised 1967) E. K. BLACKBURN

33 The laboratory detection of abnormalhaemoglobins 1961 H. LEHMANN andJ. A. M. AGER (revised 1975 byH. Lehmann and R. G. Huntsman asThe laboratory detection ofhaemoglobinopathies)39 Investigation of haemolytic anaemia1961 (Revised 1968) J. 0. SELWYN

41 Serological test for syphilis (Revised1969) A. E. WILKINSON

42 Determination of red cell enzymes(Revised 1970) C. A. WEST and T. A. J.FRANKERD

43 Mycological techniques 1962(Reprinted 1966) R. W. RIDDELL53 Preparation of sections from bonemarrow biopsies 1966 A. G. SIGNYand D. ROBERTSON SMITH

54 The investigation of blood transfusionreactions 1966 (Revised 1974)G. H. TOVEY and W. A. GILLESPIE

55 Antibiotic sensitivity tests by diffusionmethods 1966 (Revised 1972)E. JOAN STOKES andPAMELA M. WATERWORTH

56 Haemoglobinometry by thecyanmethaemoglobin method 1967S. M. LEWIS

57 Compatibility test for bloodtransfusion 1967 G. H. TOVEY andW. J. JENKINS

59 Techniques for the histologicalexamination of the eye 1967 N. ASHTON

61 Screening tests for inborn errors ofamino acid metabolism 1967D. C. CUSWORTH

62 Preparation of undecalcified bonesections 1968 H. A. SISSONS

63 Tests of combined bactericidal action1969 L. P. GARROD and PAMELA M.WATERWORTH

64 Histochemical enzyme techniques1969 I. M. P. DAWSON and M. I. FILIPE(This Broadsheet is illustrated by eightcolour transparencies which can beobtained from Dr J. Burston, Depart-ment of Histopathology, CentralLaboratory, St Mary's General Hospital,Milton Road, Portsmouth P03 6AG.Price £3-00, including postage.)

65 The immunofluorescent test forserum antinuclear factor 1969E. L. HOLBOROW and 0. D. JOHNSON

66 Cytological techniques for serous fluids1970 A. I. SPRIGGS and 0. A. N. HUSAIN

67 The laboratory investigation of mus-cular dystrophy 1970 V. DUBOWITZ,J. N. WALTON, B. P. HUGHES, andJ. N. CUMINGS

68 Simplified radial immunodiffusion1970 J. R. HOBBS

69 Immunofluorescence techniques inimmunopathology and histopathology1971 J. SWANSON BECK

70 (Revised Broadsheet 36) Quantitativedetermination of porphobilinogen andporphyrins in urine and porphyrins infaeces and erythrocytes 1971C. REMINGTON

71 The British comparative thrombo-plastin: The use of the nationalthromboplastin reagent for uniformityof laboratory control of oral anti-coagulants and expression of results1970 L. POLLER

72 The preparation of ultra-thin sectionsfor light microscopy 1970C. E. LUMSDEN and S. R. APARICIO

73 Nervous system techniques for thegeneral pathologist 1970 J. HUME ADAMand LEONARD MILLER

74 Techniques for chromosomalanalysis 1971 SYLVIA D. LAWLER

75 Quality control in haematology 1973I. CAVILL and A. JACOBS

76 A guide to the choice of opticalequipment and reagents for immuno-fluorescence techniques 1973C. E. D. TAYLOR, A. H. TOMLINSON, andG. V. HEIMER

77 Diagnosis of vitamin B1, deficiency1973 I. cHANARIN

78 Radioisotopic assay of vitamin B1, inserum 1973 J. L. RAVEN and P. BARKHAN

79 Diagnosis of folate deficiency 1973A. H. WATERS and D. L. MOLLIN

80 Estimation of bacteria and whitecells in the urine 1973 W. BRUMFrrr,A. PERCIVAL, and J. D. WILLIAMS

81 Blood culture technique 1974E. JOAN STOKES

82 Estimation of catecholamine metabo-lites in urine 1974 M. SANDLER andC. R. J. RUTHVEN

83 Platelet function tests 1975J. H. SANDERSON

84 Methods for estimating oestrogen inurine from pregnant women 1977R. E. OAKEY

85 Mycological Techniques 1977RONALD W. RIDDELL, YVONNE M. CLAYTONand HOWARD J. WINGFIELD

86 Photomicrography 1977R. S. FAWKES and A. C. LENDRUM

87 Estimation of plasma cholinsteraseactivity and the use of inhibitors for thedetermination of phenotypes 1977MARY WHITAKER

88 Examination of cerebrospinal fluidprotein 1978 o. H. GRANT

89 Handling and clinical use of bloodproducts 1978JOHN WALLACE and JOHN F. DAVIDSON

Notes on sterilization No. 1 Sterilizationand disinfection of cytoscopes 1967Notes on establishment ofa hospitalradioactive tracer service 1969Reprint No. 1 (J. clin. Path., 22, 383)The histology and cytology of changesin the epithelium of the cervix uteri1969 A. D. T. GOVAN, R. M. HAINES,F. A. LANGLEY, C. W. TAYLOR, andA. S. WOODCOCK

Reprint No. 2 (J. clin. Path., 24, 159)The perinatal postmortem examination1971 F. A. LANGLEY

Reprint No. 3 (J. clin. Path., 27, 590)The use of SI units in reporting resultsobtained in hospital laboratories 1974D. N. BARON, P. M. G. BROUGHTON,M. COHEN, T. S. LANSLEY, S. M. LEWIS, andN. K. SHINTON

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