NovaMin

A “high-tech” active ingredient used in the

most innovative professional dental products. Material Description

NovaMin is a breakthrough remineralization technology.

A tasteless white powder form.

NovaMin amplifies the natural

protective and repair mechanisms

for teeth and gums.

Extensively proven in clinical and

scientific studies at leading dental

schools around the world.

Technical Breakdown

Comprised of calcium, sodium, phosphorous and silica, all natural elements found in the body

Chemical name is Calcium Sodium Phosphosilicate

NovaMin is recognized as the only man made ingredient that directly leads to the formation of new tooth mineral (HCA)

What is NovaMin®?

What Does NovaMin® Do?

Reduces SensitivityOccludes dentin tubules: forms a protective biomimetic HCA layer.

Improves Gingival Health Antimicrobial properties & Anti-inflammatory properties reduce gingivitis.

Repairs Surface LesionsForms biomimetic HCA on tooth dentin and enamel surface lesions

The NovaMin® Solution

Hard Tissue Benefits

The NovaMin® Solution

Soft Tissue Benefits

NovaMin is also called “calcium sodium phosphosilicate”.

It is made from elements naturally found in healthy

teeth and bones: Calcium ( ), Phosphorus

( ), Sodium ( ) and Silicon ( )

NovaMin: How it Starts

pH

8.0-8.5

NovaMin reacts with saliva. Na+ ions

release, elevating pH into the range essential for

HCA formation.

Step 1: pH Elevation

+H2O

Ca2+ and P5+ ions are released, saturating

saliva with the ions needed

for remineralizati

on.

Ca2+ P5+

Step 2: Mineral Release

Na+ and Ca2+ ions overwhelm bacterial

cells’ ability to regulate their water content, leading to lysis (cell death) of harmful bacteria in

the mouth.F. Nucleatum

S. Mutans

-99.99%

-99.999%

S. Sanguis

-99.99999%

A.Naeslundii

-99.999%

Step 3: Bacterial Kill

Demineralized lesions attract

Ca2+ and P5+ ions, where they build new HCA crystal to remineralize the defect from the bottom up.

Step 4: Crystal Building

Enamel Crystal Prism

Tooth

Min

era

l Str

uct

ure

- H

ydro

xy-c

arb

onate

Apati

te (

“HC

A”)

Enamel Crystal Prism

Tooth

Min

era

l Str

uct

ure

- H

ydro

xy-c

arb

onate

Apati

te (

“HC

A”)

NovaMin particles adhere to tooth

surfaces for up to 7 days, continuing to release Na+, Ca2+,

and P5+ ions to maintain elevated

pH at the tooth surface and foster remineralization

over time.

Step 5: Time Release

Bef

ore

Tre

atm

ent

Surface Lesion In-vitro

Surface Abrasion In-Situ

Exposed Dentin In-vitro

Remineralization of Dentin & EnamelIn-vitro Study – In-Situ Models

Aft

er T

reat

men

t

NovaMin Product Focuses

• Sensitivity:Faster & better results

Addresses symptom, not cause.

• Gingivitis: Faster results

Less controversial ingredient

• Root Caries/Remineralization:Adult caries predominantly related to hyposalivation.

NovaMin directly addresses this etiology.

NovaMin & SensitivityNovaMin Therapy Paste Results

Clinical Results Vs. Placebo

Averaged Across Methods

01

23

45

67

8

Baseline 1 week 2 weeks 3 weeks 4 weeks

VA

S S

core

NovaMin

Control

p<0.001

NovaMin & SensitivityNovaMin Therapy Paste ResultsClinical Results Vs. Other Actives

NovaMin Vs. Potassium Nitrate

0.0

2.0

4.0

6.0

8.0

0 2 4 12

Weeks

VA

S W

ater Potassium Nitrate

Stannous Fluoride

NovaMin

p<0.05

Product Tested Code

7.5% NM/1100 ppm MFP 1

7.5% NM 2

Company CR 5000 ppm NaF 3

Company CG 1.1 ppm MFP 4

0% NM/O ppm F 5

NovaMin vs. Fluoride Remineralization of Dentin

NTI-UCSF In-vitro Study – Dentin Remin/Demin Model

0

200

400

600

800

1000

1200

1400

1 2 3 4 5

Product Code Tested

Del

ta Z

Log Reduction in Microbial CFU's - 2 Minute Exposure to 1:3 Dilution

-9

-8

-7

-6

-5

-4

-3

-2

-1

0S mutans S sanguis F nucleatum A naeslundii

Bacterial Species

Lo

g R

ed

uc

tio

n in

Via

bili

ty

NovaMin Non Aqueous Toothpaste

NovaMin Powder

Colgate Red Box Toothpaste

NovaMin and GingivitisAnti-Microbial Properties

Summary of Gingival Index Findings

0

0.2

0.4

0.6

0.8

1

1.2

1.4

baseline 6 week

Time Period

GB

I NovaMin

Placebo-59%

p<0.01

NovaMin and GingivitisPilot Clinical Study – Gingival Bleeding Index

Summary of Plaque Index Findings

0

0.2

0.4

0.6

0.8

1

1.2

1.4

1.6

1.8

baseline 6 week

Time Period

PL

I NovaMin

Placebo

p<0.025

NovaMin and GingivitisPilot Clinical Study – Plaque Index

NovaMin Dentifrice + F Treated Sample

Fluoride Dentifrice Treated Sample

Demineralized Untreated Sample

Sound Enamel

Surface Lesion ~ 100µm

NovaMin/Fluoride Enamel

Remineralization In-vitro Study – Remin/Demin Model

Sound Enamel Sound Enamel

Lesion Area

0

10

20

30

40

Demin F paste F + NovaMin

Treatment Group

Lesi

on A

rea

(sq.

m

icro

ns x

1000

)

-30% -45%

p<0.001

NovaMin/Fluoride Enamel Remineralization

In-vitro Study – Remin/Demin Model