NORTON HERBERT NEFF, PH.D. - Heart Lung | Ohio HERBERT NEFF, PH.D. DATE AND PLACE OF BIRTH: May 10, 1935; Philadelphia, Pennsylvania ... N.H., Tozer, T.N., Hammer, W. and Brodie, B.B.: Kinetics of release of Neff, N.H. 4 norepinephrine by tyramine ...

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  • Curriculum Vitae

    NORTON HERBERT NEFF, PH.D.

    DATE AND PLACE OF BIRTH: May 10, 1935; Philadelphia, Pennsylvania

    HOME ADDRESS: 2191 Waltham Road, Columbus, Ohio 43221

    WORK ADDRESS: The Ohio State University College of MedicineDepartment of Pharmacology, 5067 Graves Hall,333 West Tenth Avenue, Columbus, Ohio 43210, USATelephone: 614/688-3887; FAX: 614/292-7232E-mail: Neff.2@osu.edu

    EDUCATION:

    1954-1958 B.Sc., Philadelphia College of Pharmacy and ScienceMajor -- Pharmacy

    1958-1960 M.Sc., Philadelphia College of Pharmacy and Science

    Major -- Pharmacology: Minor -- Chemistry

    1960-1964 Ph.D., Philadelphia College of Pharmacy and ScienceMajor -- Pharmacology: Minor -- Chemistry

    BRIEF CHRONOLOGY OF EMPLOYMENT:

    1958-1963 Laboratory Assistant in Pharmacology, Department of Pharmacology,Philadelphia College of Pharmacy and Science

    1958-1961 Pharmacologist, LaWall and Harrisson Laboratories, Philadelphia ,Pennsylvania (Part-time)

    1961-1963 Chemist, Radioisotope Service, Veterans Administration Hospital,Philadelphia, Pennsylvania (Part-time)

    1963-1965 Postdoctoral Research Fellow, Laboratory of Chemical Pharmacology,National Heart Institute, Bethesda, Maryland

    1965-1967 Research Associate, Department of Pharmacology, College of Physiciansand Surgeons, Columbia University, New York, N.Y.

    1967-1968 Associate in Pharmacology, Department of Pharmacology, College ofPhysicians and Surgeons, Columbia University, New York, N.Y.

    1968-1971 Pharmacologis t, Laboratory of Preclinical Pharmacology, National Institute

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    of Mental Health, Saint Elizabeth's Hospital, Washington, D.C. 20032

    1971-1984 Chief, Section on Biochemical Pharmacology, Laboratory of PreclinicalPharmacology, National Institute of Mental Health, Saint Elizabeth'sHospital, Washington, D.C. 20032

    1984- 2000 Professor and Chairman, Department of Pharmacology, The Ohio StateUniversity, College of Medicine, Columbus, Ohio 43210-1239

    1995- 2000 Training Grant Program Director, Research Training in Neuropharmacology.The Ohio State University, College of Medicine and Public Health,Columbus, Ohio 43210-1239.

    2000-present Professor, Department of Pharmacology, The Ohio State University, Collegeof Medicine and Public Health, Columbus, Ohio 43210-1239

    2001-present Professor, Department of Psychiatry, The Ohio State University, College ofMedicine and Public Health, Columbus, Ohio.

    PROFESSIONAL MEMBERSHIPS:

    American Association for the Advancement of Science (AAAS)American Society for Pharmacology and Experimental Therapeutics (ASPET)American Society for Neurochemistry (ASN)International Society for Neurochemistry (ISN)International Brain Research Organization (IBRO)Society for Neuroscience (SNS)American College for Neuropsychopharmacology (ACNP)Association for Medical School Pharmacology (AMSP)Collegium Internationale Neuro-Psychopharmacologicum (CINP)

    RECOGNITION: 1981, The Institute for Scientific Information (ISI) reported researchpublications as most cited in the world literature.

    EDITORIAL POSTS:

    Previous

    Editorial Advisory Board, Life Sciences: 1973-1978Advisory Board, Essays in Neurochemistry and Neuropharmacology: 1977-1982.Editorial Board, Neurochemical Research: 1976-1983U.S. Editorial Advisory Board, Neuropharmacology: 1965-1992Editorial Advisory Board, Archives Internationales De Pharmacodynamie et De Therapie.Editorial Advisory Board, Journal of Ocular PharmacologyU.S.A. Executive Editor, Neurochemistry International

    Editorial Board, Journal of NeurochemistryCurrent

    Editorial Board, Pharmacology

  • Neff, N.H. 3

    Editorial Advisory Board, Journal of Pharmacology and Experimental Therapeutics, Editorial Board, CNS Drug ReviewsEditorial Board, Biochemical Pharmacology

    ACADEMIC POSITIONS:

    Professorial Lecturer in Pharmacology, George Washington University School of Medicineand Health Services: 1974-1985

    ACADEMIC COMMITTEES

    Appointments, Promotion and Tenure Advisory Committee, College of Medicine, 1984-1986.Executive Committee of the College of Medicine, 1984-1991.Council of Chairs of the College of Medicine, 1991-2000University Senate, 1992-1995Council of Research and Graduate Studies, 1993-1996University Research Committee, 1993-1996Ohio State University Research Foundation Board of Directors, 1997-2000Ohio State University Research Foundation Principal Investigator Advisory Committee,1997-2000Ohio State University Research Foundation Executive Committee, 1999-2000University Senate, 1999-2002University Research Committee, 1999-2002Executive Committee, School of Biomedical Sciences, 1999-2000Ohio State University Research Foundation Board of Directors, 2001-

    National Research Review CommitteesPsychopathology and Clinical Biology Research Review Committee, ADAMHA, 1984-1987.

    PUBLICATIONS

    1. Neff, N.H.: Current status of thrombolytic agents. Am. J. Pharm. 131:7, 1959.

    2. Neff, N.H. and Rossi, G.V.: A pharmacological evaluation of trifluorinatedphenothiazines. Arch. Int. Pharmacodyn. 136:476, 1962.

    3. Neff, N.H. and Rossi, G.V.: Mescaline. Am. J. Pharm. 135:319, 1963.

    4. Gennaro, A.F., Neff, N.H. and Rossi, G.V.: 4,5-Trimethoxymandelic acid. J. Chem. Eng.Data 9:109, 1964.

    5. Neff, N.H., Rossi, G.V., Chase, G.D. and Rabinowitz, J.L.: Distribution and metabolismof mescaline C in the cat brain. J. Pharmacol. Exp. Ther. 144:1, 1964.

    6. Neff, N.H., Tozer, T.N., Hammer, W. and Brodie, B.B.: Kinetics of release of

  • Neff, N.H. 4

    norepinephrine by tyramine. Life Sci. 4:1869, 1965.

    7. Costa, E. and Neff, N.H.: Isotopic and non-isotopic measurements of the rate ofcatecholamine biosynthesis. In: Costa, E., Cote, L., Yahr, M.D. (eds.) Biochemistry andPharmacology of the Basal Ganglia. New York, Raven Press, p. 141-156, 1966.

    8. Tozer, T.N., Neff, N.H. and Brodie, B.B.: Application of steady-state kinetics todetermine turnover rate and turnover time of brain serotonin in normal and reserpine-treated rats. J. Pharmacol. Exp. Ther. 153:177, 1966.

    9. Neff, N.H. and Costa, E.: The influence of monoamine oxidase inhibition oncatecholamine synthesis. Life Sci. 5:951, 1966.

    10. Brodie, B.B., Costa, E., Dlabac, A., Neff, N.H. and Smookler, H.H.: Application ofsteady-state kinetics to the est imation of synthesis rate and turnover time of tissuecatecholamines. J. Pharmacol. Exp. Ther. 154:493, 1966.

    11. Costa, E. and Neff, N.H.: The dynamic process for catecholamine storage as a site fordrug action. Proc. V. Int'l. CINP Meeting Excerpta Medica International Congress Series129:959, 1966.

    12. Neff, N.H. and Costa, E.: Effect of tricyclic antidepressants and chlorpromazine on braincatecholamine synthesis. Proc. of the International Symposium on AntidepressantDrugs. Excerpta Medica International Congress Series 122:242, 1966.

    13. Neff, N.H. and Tozer, T.N.: In vivo measurement of brain serotonin turnover. Advancesin Pharmacology, Vol. 6:97, 1967.

    14. Neff, N.H., Tozer, T.N. and Brodie, B.B.: Application of steady-state kinetics to studiesof the transfer of 5HIAA from brain to plasma. J. Pharmacol. Exp. Ther. 158:214, 1967.

    15. Costa, E. and Neff, N.H.: The physiological role of MAO in monoamine storage asrevealed by MAO inhibitors. Proc. III Int. Pharmacological Congress, Sao Paulo, Brazil,1966. In: Interactions Between Pharmacological Activity of MAO and Their Effects inMan. Pergamon Press, Oxford, p. 15, 1968.

    16. Costa, E. and Neff, N.H.: Importance of turnover measurements to elucidate thefunction of neuronal monoamines. In: Topics in Medicinal Chemistry, Vol. 2, J.L.Rabinowitz and R.M. Myerson (eds.) John Wiley and Sons, Inc., New York, p. 363-407,1968.

    17. Neff, N.H., Tozer, T.N., Hammer, W., Costa, E. and Brodie, B.B.: Application of steady-state kinetics to uptake and decline of H-NE in the rat heart. J. Pharmacol. Exp. Ther.160:48, 1968.

    18. Neff, N.H. and Costa, E.: Application of steady-state kinetics to study catecholamineturnover after monoamine oxidase inhibition or reserpine administration. J. Pharmacol.Exp. Ther. 160:40, 1968.

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    19. Costa, E. and Neff, N.H.: Principles of steady-state kinetics as applied to the evaluationof drug effects on adrenergic neurons. In: Importance of Fundamental Princ iples inDrug Evaluation, D. Tedeschi (ed.), Raven Press, p. 185-202, 1968.

    20. Ngai, S.H., Neff, N.H. and Costa, E.: Effect of pargyline treatment on the rate ofconversion of tyrosine C to norepinephrine C. Life Sci. 7:847, 1968.

    21. Spano, P.F., Connor, J.D. and Neff, N.H.: Estimation of the synthesis rate of dopaminein the cat caudate nucleus. Atti. Acc. Med. Lomb. 23:1110, 1968.

    22. Spano, P.F., Neff, N.H. and Costa, E.: Chlorpromazine and trifluoperazineconcentrations in brain as a function of dose. Atti. Acc. Med. Lomb. 23:1096, 1968.

    23. Costa, E., Spano, P.F., Groppetti, A., Algeri, S. and Neff, N.H.: Simultaneousdetermination of tryptophan, tyrosine, catecholamines and serotonin specific activity inrat brain. Atti. Acc. Med. Lomb. 23:1100, 1968.

    24. Neff, N.H., Ngai, S.H., Wang, C.T. and Costa, E.: Calculation of the rate ofcatecholamine synthesis from the rate of conversion of 14C-tyrosine to catecholamines:Effect of adrenal demedullation on synthesis rate. Mol. Pharmacol. 5:90-99, 1969.

    25. Neff, N.H., Barrett, R.E. and Costa, E.: Kinetic and fluorescent histochemical analysisof the serotonin compartments in rat pineal gland. Eur. J. Pharmacol. 5:348-356, 1969.

    26. Stern, D.N., Fieve, R.R., Neff, N.H. and Costa, E.: The effect of lithium chlorideadministration on brain and heart norepinephrine turnover rates. Psychopharmacolog ia14:315-322, 1969.

    27. Neff, N.H., Lin, R.C., Ngai, S.H. and Costa E.: Turnover rate measurements of brainserotonin in unanesthetized rats. In: E. Costa and P. Greengard (eds.) Advances inBiochemical Psychopharmacology, Vol. 1, New York, Raven Press, p. 91, 1969.

    28. Costa, E., Neff, N.H. and Ngai, S.H.: Regulation of metaraminol efflux from rat heart andsalivary gland. Brit. J. Pharmacol. 36:153-160, 1969.

    29. Ngai, S.H., Neff, N.H. and Costa, E.: The effect of cyclopropane and halothane on thebiosynthesis of norepinephrine in vivo: conversion of C-tyrosine to catecholamines. J.Anesthesiology 31:53, 1969.

    30. Lin, R.C., Costa, E., Neff, N.H., Wang, C.T. and Ngai, S.H.: In vivo measurement of 5-hydroxytrytamine turnover rate in the rat brain from the conversion of C-tryptophan to C5-hydroxytryptamine. J. Pharmacol. Exp. Ther. 160:233-238, 1969.

    31. Lin, R.C., Neff, N.H., Ngai, S.H. and Costa, E.: Turnover rates of serotonin andnorepinephrine in brain of normal and pargyline-treated rats. Life Sci. 8:1077-1084,1969.

    32. Neff, N.H., Barrett, R.E.and Costa, E.: Selective depletion of caudate nucleus dopamineand serotonin during chronic manganese dioxide administration to squirrel monkeys.

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    Experientia 25:1140-1141, 1969.

    33. Costa, E. and Neff, N.H.: Estimation of turnover rates to study the metabolic regulationof the steady-state level of neuronal monoamines. Handbook of Neurochemistry 4:45,1970.

    34. Spano, P.F., Neff, N.H., Macko, E. and Costa, E.: Efflux of chlorpromazine andtrifluorperazine from rat brain. J. Pharmacol. Exp. Ther. 174:20-26, 1970.

    35. Bapna, J., Neff, N.H. and Costa, E.: The mechanism of tissue norepinephrine depletionby alpha-alpha-dipyridyl. Neuropharmacol. 9:333-340, 1970.

    36. Connor, J.D. and Neff, N.H.: Dopamine concentrations in the caudate nucleus of thedeveloping cat. Life Sci. 9:No. 20, 1165-1168, 1970.

    37. Neff, N.H., Spano, P.F., Groppetti, A., Wang, C.T. and Costa, E.: A simple procedurefor calculating the synthesis rate of norepinephrine, dopamine and serotonin in rat brain.J. Pharmacol. Exp. Ther. 176:701-709, 1971.

    38. Spano, P.F. and Neff, N.H.: A procedure for the simultaneous determination ofdopamine, 3-methoxy-4-hydroxyphenylacetic acid and 3,4-dihydroxyphenylacetic acidin brain. Anal. Biochem. 42:113-118, 1971.

    39. Hoffer, B.J., Neff, N.H. and Siggins, G.R.: Microiontophoretic release of norepinephrinefrom micropipettes. Neuropharmacol. 10:175-180, 1971.

    40. Goridis, C. and Neff, N.H.: Evidence for a specific monoam ine oxidase associated withsympathetic nerves. Neuropharmacol. 10:557-564, 1971.

    41. Goridis, C. and Neff, N.H.: Monoamine oxidase: An approximation of turnover rates. J.Neurochem. 18:1673-1682, 1971.

    42. Goridis, C. and Neff, N.H.: Monoamine oxidase in sympathetic nerves: A transmitterspecific enzyme type. Br. J. Pharmacol. 43:814-818, 1971.

    43. Bapna, J., Neff, N.H. and Costa, E.: A method for studying norepinephrine andserotonin metabolism in small regions of rat brain: Effect of ovariectomy on aminemetabolism in anterior and posterior hypothalamus. Endocrinology, 89:1345-1349,1971.

    44. Spano, P.F. and Neff, N.H.: Metabolic fate of caudate nucleus dopamine. Brain Res.42:139-145, 1972.

    45. Goridis, C. and Neff, N.H.: Evidence for specific monoamine oxidases in humansympathetic nerve and pineal gland. Proc. Soc. Exp. Biol. and Med. 140:573-574, 1972.

    46. Yang, H.-Y.T., Goridis, C. and Neff, N.H.: Properties of sympathetic nerve and pinealmonoamine oxidases. J. Neurochem. 19:1241-1250, 1972.

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    47. Meek, J.L. and Neff, N.H.: Acidic and neutral metabolites of norepinephrine: Theirmetabolsim and transport from brain. J. Pharmacol. Exp. Ther. 181:457-462, 1972.

    48. Meek, J.L. and Neff, N.H.: Tryptophan 5-hydroxylase: Approximation of half-life and rateof axonal transport. J. Neurochem. 19:1519-1525, 1972.

    49. Neff, N.H.: Methods for estimating the in vivo rate of formation of norepinephrinedopamine and serotonin in nerve tissue. In: Rall, E. and Kopin, I.J. (eds.) Methods inInvestigative and Diagnostic Endocrinology. North Holland Publ. Co., p. 604-640, 1972.

    50. Neff, N.H. and Goridis, C.: Neuronal monoamine oxidase: Specific enzyme types andtheir rates of formation. Adv. in Biochem. Psychopharmacol. 5:307-323, 1972.

    51. Meek, J.L. and Neff, N.H.: Fluorimetric estimation of 3-methoxy-4-hydroxy- phenylglycolsulfate in brain. Br. J. Pharmacol. 45:435-441, 1972.

    52. Yang, H.-Y.T. and Neff, N.H.: Distribution and properties of angiotensin convertingenzyme of rat brain. J. Neurochem. 19:2443-2450, 1972.

    53. Goridis, C., Meeks, J.L. and Neff, N.H.: Monoamine oxidase activity of rat spinal cordafter transection. Life Sci. 11:861-866, 1972.

    54. Meek, J.L. and Neff, N.H.: The rate of formation of 3-m ethoxy-4-hydroxy-phenylethyleneglycol sulfate in brain as an estimate of the rate of formation ofnorepinephrine. J. Pharmacol. Exp. Ther. 184:570-575, 1973.

    55. Meek, J.L. and Neff, N.H.: Is cerebrospinal fluid the major avenue for the removal of 5-hydroxyindoleactric acid from the brain? J. Neuropharmacol. 12:497-499, 1973.

    56. Meek, J.L. and Neff, N.H.: Biogenic amines and their metabolites as substrates forphenol sulfotransferase (EC 2.8.2.1) of brain and liver. J. Neurochem. 21:1-9, 1973.

    57. Coquil, J.F., Goridis, C., Mack, G. and Neff, N.H.: Monoamine oxidase in rat arteries:Evidence for different forms and selective localization. Brit. J. Pharmac...