Curriculum Vitae

NORTON HERBERT NEFF, PH.D.

DATE AND PLACE OF BIRTH: May 10, 1935; Philadelphia, Pennsylvania

HOME ADDRESS: 2191 Waltham Road, Columbus, Ohio 43221

WORK ADDRESS: The Ohio State University College of MedicineDepartment of Pharmacology, 5067 Graves Hall,333 West Tenth Avenue, Columbus, Ohio 43210, USATelephone: 614/688-3887; FAX: 614/292-7232E-mail: Neff.2@osu.edu

EDUCATION:

1954-1958 B.Sc., Philadelphia College of Pharmacy and ScienceMajor -- Pharmacy

1958-1960 M.Sc., Philadelphia College of Pharmacy and Science

Major -- Pharmacology: Minor -- Chemistry

1960-1964 Ph.D., Philadelphia College of Pharmacy and ScienceMajor -- Pharmacology: Minor -- Chemistry

BRIEF CHRONOLOGY OF EMPLOYMENT:

1958-1963 Laboratory Assistant in Pharmacology, Department of Pharmacology,Philadelphia College of Pharmacy and Science

1958-1961 Pharmacologist, LaWall and Harrisson Laboratories, Philadelphia ,Pennsylvania (Part-time)

1961-1963 Chemist, Radioisotope Service, Veterans Administration Hospital,Philadelphia, Pennsylvania (Part-time)

1963-1965 Postdoctoral Research Fellow, Laboratory of Chemical Pharmacology,National Heart Institute, Bethesda, Maryland

1965-1967 Research Associate, Department of Pharmacology, College of Physiciansand Surgeons, Columbia University, New York, N.Y.

1967-1968 Associate in Pharmacology, Department of Pharmacology, College ofPhysicians and Surgeons, Columbia University, New York, N.Y.

1968-1971 Pharmacologis t, Laboratory of Preclinical Pharmacology, National Institute

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of Mental Health, Saint Elizabeth's Hospital, Washington, D.C. 20032

1971-1984 Chief, Section on Biochemical Pharmacology, Laboratory of PreclinicalPharmacology, National Institute of Mental Health, Saint Elizabeth'sHospital, Washington, D.C. 20032

1984- 2000 Professor and Chairman, Department of Pharmacology, The Ohio StateUniversity, College of Medicine, Columbus, Ohio 43210-1239

1995- 2000 Training Grant Program Director, Research Training in Neuropharmacology.The Ohio State University, College of Medicine and Public Health,Columbus, Ohio 43210-1239.

2000-present Professor, Department of Pharmacology, The Ohio State University, Collegeof Medicine and Public Health, Columbus, Ohio 43210-1239

2001-present Professor, Department of Psychiatry, The Ohio State University, College ofMedicine and Public Health, Columbus, Ohio.

PROFESSIONAL MEMBERSHIPS:

American Association for the Advancement of Science (AAAS)American Society for Pharmacology and Experimental Therapeutics (ASPET)American Society for Neurochemistry (ASN)International Society for Neurochemistry (ISN)International Brain Research Organization (IBRO)Society for Neuroscience (SNS)American College for Neuropsychopharmacology (ACNP)Association for Medical School Pharmacology (AMSP)Collegium Internationale Neuro-Psychopharmacologicum (CINP)

RECOGNITION: 1981, The Institute for Scientific Information (ISI) reported researchpublications as most cited in the world literature.

EDITORIAL POSTS:

Previous

Editorial Advisory Board, Life Sciences: 1973-1978Advisory Board, Essays in Neurochemistry and Neuropharmacology: 1977-1982.Editorial Board, Neurochemical Research: 1976-1983U.S. Editorial Advisory Board, Neuropharmacology: 1965-1992Editorial Advisory Board, Archives Internationales De Pharmacodynamie et De Therapie.Editorial Advisory Board, Journal of Ocular PharmacologyU.S.A. Executive Editor, Neurochemistry International

Editorial Board, Journal of NeurochemistryCurrent

Editorial Board, Pharmacology

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Editorial Advisory Board, Journal of Pharmacology and Experimental Therapeutics, Editorial Board, CNS Drug ReviewsEditorial Board, Biochemical Pharmacology

ACADEMIC POSITIONS:

Professorial Lecturer in Pharmacology, George Washington University School of Medicineand Health Services: 1974-1985

ACADEMIC COMMITTEES

Appointments, Promotion and Tenure Advisory Committee, College of Medicine, 1984-1986.Executive Committee of the College of Medicine, 1984-1991.Council of Chairs of the College of Medicine, 1991-2000University Senate, 1992-1995Council of Research and Graduate Studies, 1993-1996University Research Committee, 1993-1996Ohio State University Research Foundation Board of Directors, 1997-2000Ohio State University Research Foundation Principal Investigator Advisory Committee,1997-2000Ohio State University Research Foundation Executive Committee, 1999-2000University Senate, 1999-2002University Research Committee, 1999-2002Executive Committee, School of Biomedical Sciences, 1999-2000Ohio State University Research Foundation Board of Directors, 2001-

National Research Review CommitteesPsychopathology and Clinical Biology Research Review Committee, ADAMHA, 1984-1987.

PUBLICATIONS

1. Neff, N.H.: Current status of thrombolytic agents. Am. J. Pharm. 131:7, 1959.

2. Neff, N.H. and Rossi, G.V.: A pharmacological evaluation of trifluorinatedphenothiazines. Arch. Int. Pharmacodyn. 136:476, 1962.

3. Neff, N.H. and Rossi, G.V.: Mescaline. Am. J. Pharm. 135:319, 1963.

4. Gennaro, A.F., Neff, N.H. and Rossi, G.V.: 4,5-Trimethoxymandelic acid. J. Chem. Eng.Data 9:109, 1964.

5. Neff, N.H., Rossi, G.V., Chase, G.D. and Rabinowitz, J.L.: Distribution and metabolismof mescaline C in the cat brain. J. Pharmacol. Exp. Ther. 144:1, 1964.

6. Neff, N.H., Tozer, T.N., Hammer, W. and Brodie, B.B.: Kinetics of release of

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norepinephrine by tyramine. Life Sci. 4:1869, 1965.

7. Costa, E. and Neff, N.H.: Isotopic and non-isotopic measurements of the rate ofcatecholamine biosynthesis. In: Costa, E., Cote, L., Yahr, M.D. (eds.) Biochemistry andPharmacology of the Basal Ganglia. New York, Raven Press, p. 141-156, 1966.

8. Tozer, T.N., Neff, N.H. and Brodie, B.B.: Application of steady-state kinetics todetermine turnover rate and turnover time of brain serotonin in normal and reserpine-treated rats. J. Pharmacol. Exp. Ther. 153:177, 1966.

9. Neff, N.H. and Costa, E.: The influence of monoamine oxidase inhibition oncatecholamine synthesis. Life Sci. 5:951, 1966.

10. Brodie, B.B., Costa, E., Dlabac, A., Neff, N.H. and Smookler, H.H.: Application ofsteady-state kinetics to the est imation of synthesis rate and turnover time of tissuecatecholamines. J. Pharmacol. Exp. Ther. 154:493, 1966.

11. Costa, E. and Neff, N.H.: The dynamic process for catecholamine storage as a site fordrug action. Proc. V. Int'l. CINP Meeting Excerpta Medica International Congress Series129:959, 1966.

12. Neff, N.H. and Costa, E.: Effect of tricyclic antidepressants and chlorpromazine on braincatecholamine synthesis. Proc. of the International Symposium on AntidepressantDrugs. Excerpta Medica International Congress Series 122:242, 1966.

13. Neff, N.H. and Tozer, T.N.: In vivo measurement of brain serotonin turnover. Advancesin Pharmacology, Vol. 6:97, 1967.

14. Neff, N.H., Tozer, T.N. and Brodie, B.B.: Application of steady-state kinetics to studiesof the transfer of 5HIAA from brain to plasma. J. Pharmacol. Exp. Ther. 158:214, 1967.

15. Costa, E. and Neff, N.H.: The physiological role of MAO in monoamine storage asrevealed by MAO inhibitors. Proc. III Int. Pharmacological Congress, Sao Paulo, Brazil,1966. In: Interactions Between Pharmacological Activity of MAO and Their Effects inMan. Pergamon Press, Oxford, p. 15, 1968.

16. Costa, E. and Neff, N.H.: Importance of turnover measurements to elucidate thefunction of neuronal monoamines. In: Topics in Medicinal Chemistry, Vol. 2, J.L.Rabinowitz and R.M. Myerson (eds.) John Wiley and Sons, Inc., New York, p. 363-407,1968.

17. Neff, N.H., Tozer, T.N., Hammer, W., Costa, E. and Brodie, B.B.: Application of steady-state kinetics to uptake and decline of H-NE in the rat heart. J. Pharmacol. Exp. Ther.160:48, 1968.

18. Neff, N.H. and Costa, E.: Application of steady-state kinetics to study catecholamineturnover after monoamine oxidase inhibition or reserpine administration. J. Pharmacol.Exp. Ther. 160:40, 1968.

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19. Costa, E. and Neff, N.H.: Principles of steady-state kinetics as applied to the evaluationof drug effects on adrenergic neurons. In: Importance of Fundamental Princ iples inDrug Evaluation, D. Tedeschi (ed.), Raven Press, p. 185-202, 1968.

20. Ngai, S.H., Neff, N.H. and Costa, E.: Effect of pargyline treatment on the rate ofconversion of tyrosine C to norepinephrine C. Life Sci. 7:847, 1968.

21. Spano, P.F., Connor, J.D. and Neff, N.H.: Estimation of the synthesis rate of dopaminein the cat caudate nucleus. Atti. Acc. Med. Lomb. 23:1110, 1968.

22. Spano, P.F., Neff, N.H. and Costa, E.: Chlorpromazine and trifluoperazineconcentrations in brain as a function of dose. Atti. Acc. Med. Lomb. 23:1096, 1968.

23. Costa, E., Spano, P.F., Groppetti, A., Algeri, S. and Neff, N.H.: Simultaneousdetermination of tryptophan, tyrosine, catecholamines and serotonin specific activity inrat brain. Atti. Acc. Med. Lomb. 23:1100, 1968.

24. Neff, N.H., Ngai, S.H., Wang, C.T. and Costa, E.: Calculation of the rate ofcatecholamine synthesis from the rate of conversion of 14C-tyrosine to catecholamines:Effect of adrenal demedullation on synthesis rate. Mol. Pharmacol. 5:90-99, 1969.

25. Neff, N.H., Barrett, R.E. and Costa, E.: Kinetic and fluorescent histochemical analysisof the serotonin compartments in rat pineal gland. Eur. J. Pharmacol. 5:348-356, 1969.

26. Stern, D.N., Fieve, R.R., Neff, N.H. and Costa, E.: The effect of lithium chlorideadministration on brain and heart norepinephrine turnover rates. Psychopharmacolog ia14:315-322, 1969.

27. Neff, N.H., Lin, R.C., Ngai, S.H. and Costa E.: Turnover rate measurements of brainserotonin in unanesthetized rats. In: E. Costa and P. Greengard (eds.) Advances inBiochemical Psychopharmacology, Vol. 1, New York, Raven Press, p. 91, 1969.

28. Costa, E., Neff, N.H. and Ngai, S.H.: Regulation of metaraminol efflux from rat heart andsalivary gland. Brit. J. Pharmacol. 36:153-160, 1969.

29. Ngai, S.H., Neff, N.H. and Costa, E.: The effect of cyclopropane and halothane on thebiosynthesis of norepinephrine in vivo: conversion of C-tyrosine to catecholamines. J.Anesthesiology 31:53, 1969.

30. Lin, R.C., Costa, E., Neff, N.H., Wang, C.T. and Ngai, S.H.: In vivo measurement of 5-hydroxytrytamine turnover rate in the rat brain from the conversion of C-tryptophan to C5-hydroxytryptamine. J. Pharmacol. Exp. Ther. 160:233-238, 1969.

31. Lin, R.C., Neff, N.H., Ngai, S.H. and Costa, E.: Turnover rates of serotonin andnorepinephrine in brain of normal and pargyline-treated rats. Life Sci. 8:1077-1084,1969.

32. Neff, N.H., Barrett, R.E.and Costa, E.: Selective depletion of caudate nucleus dopamineand serotonin during chronic manganese dioxide administration to squirrel monkeys.

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Experientia 25:1140-1141, 1969.

33. Costa, E. and Neff, N.H.: Estimation of turnover rates to study the metabolic regulationof the steady-state level of neuronal monoamines. Handbook of Neurochemistry 4:45,1970.

34. Spano, P.F., Neff, N.H., Macko, E. and Costa, E.: Efflux of chlorpromazine andtrifluorperazine from rat brain. J. Pharmacol. Exp. Ther. 174:20-26, 1970.

35. Bapna, J., Neff, N.H. and Costa, E.: The mechanism of tissue norepinephrine depletionby alpha-alpha-dipyridyl. Neuropharmacol. 9:333-340, 1970.

36. Connor, J.D. and Neff, N.H.: Dopamine concentrations in the caudate nucleus of thedeveloping cat. Life Sci. 9:No. 20, 1165-1168, 1970.

37. Neff, N.H., Spano, P.F., Groppetti, A., Wang, C.T. and Costa, E.: A simple procedurefor calculating the synthesis rate of norepinephrine, dopamine and serotonin in rat brain.J. Pharmacol. Exp. Ther. 176:701-709, 1971.

38. Spano, P.F. and Neff, N.H.: A procedure for the simultaneous determination ofdopamine, 3-methoxy-4-hydroxyphenylacetic acid and 3,4-dihydroxyphenylacetic acidin brain. Anal. Biochem. 42:113-118, 1971.

39. Hoffer, B.J., Neff, N.H. and Siggins, G.R.: Microiontophoretic release of norepinephrinefrom micropipettes. Neuropharmacol. 10:175-180, 1971.

40. Goridis, C. and Neff, N.H.: Evidence for a specific monoam ine oxidase associated withsympathetic nerves. Neuropharmacol. 10:557-564, 1971.

41. Goridis, C. and Neff, N.H.: Monoamine oxidase: An approximation of turnover rates. J.Neurochem. 18:1673-1682, 1971.

42. Goridis, C. and Neff, N.H.: Monoamine oxidase in sympathetic nerves: A transmitterspecific enzyme type. Br. J. Pharmacol. 43:814-818, 1971.

43. Bapna, J., Neff, N.H. and Costa, E.: A method for studying norepinephrine andserotonin metabolism in small regions of rat brain: Effect of ovariectomy on aminemetabolism in anterior and posterior hypothalamus. Endocrinology, 89:1345-1349,1971.

44. Spano, P.F. and Neff, N.H.: Metabolic fate of caudate nucleus dopamine. Brain Res.42:139-145, 1972.

45. Goridis, C. and Neff, N.H.: Evidence for specific monoamine oxidases in humansympathetic nerve and pineal gland. Proc. Soc. Exp. Biol. and Med. 140:573-574, 1972.

46. Yang, H.-Y.T., Goridis, C. and Neff, N.H.: Properties of sympathetic nerve and pinealmonoamine oxidases. J. Neurochem. 19:1241-1250, 1972.

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47. Meek, J.L. and Neff, N.H.: Acidic and neutral metabolites of norepinephrine: Theirmetabolsim and transport from brain. J. Pharmacol. Exp. Ther. 181:457-462, 1972.

48. Meek, J.L. and Neff, N.H.: Tryptophan 5-hydroxylase: Approximation of half-life and rateof axonal transport. J. Neurochem. 19:1519-1525, 1972.

49. Neff, N.H.: Methods for estimating the in vivo rate of formation of norepinephrinedopamine and serotonin in nerve tissue. In: Rall, E. and Kopin, I.J. (eds.) Methods inInvestigative and Diagnostic Endocrinology. North Holland Publ. Co., p. 604-640, 1972.

50. Neff, N.H. and Goridis, C.: Neuronal monoamine oxidase: Specific enzyme types andtheir rates of formation. Adv. in Biochem. Psychopharmacol. 5:307-323, 1972.

51. Meek, J.L. and Neff, N.H.: Fluorimetric estimation of 3-methoxy-4-hydroxy- phenylglycolsulfate in brain. Br. J. Pharmacol. 45:435-441, 1972.

52. Yang, H.-Y.T. and Neff, N.H.: Distribution and properties of angiotensin convertingenzyme of rat brain. J. Neurochem. 19:2443-2450, 1972.

53. Goridis, C., Meeks, J.L. and Neff, N.H.: Monoamine oxidase activity of rat spinal cordafter transection. Life Sci. 11:861-866, 1972.

54. Meek, J.L. and Neff, N.H.: The rate of formation of 3-m ethoxy-4-hydroxy-phenylethyleneglycol sulfate in brain as an estimate of the rate of formation ofnorepinephrine. J. Pharmacol. Exp. Ther. 184:570-575, 1973.

55. Meek, J.L. and Neff, N.H.: Is cerebrospinal fluid the major avenue for the removal of 5-hydroxyindoleactric acid from the brain? J. Neuropharmacol. 12:497-499, 1973.

56. Meek, J.L. and Neff, N.H.: Biogenic amines and their metabolites as substrates forphenol sulfotransferase (EC 2.8.2.1) of brain and liver. J. Neurochem. 21:1-9, 1973.

57. Coquil, J.F., Goridis, C., Mack, G. and Neff, N.H.: Monoamine oxidase in rat arteries:Evidence for different forms and selective localization. Brit. J. Pharmacol. 48:590-599,1973.

58. Goridis, C. and Neff, N.H.: Neuronal and hormonal influences on the turnover ofmonoamine oxidase in salivary gland. Biochem. Pharmacol. 22:2501-2510, 1973.

59. Yang, H.-Y.T. and Neff, N.H.: Differential distribution of angiotensin converting enzymein the anterior and posterior lobe of the rat pituitary. J. Neurochem. 21:1035-1036, 1973.

60. Yang, H.-Y.T. and Neff, N.H.: $-phenylethylamine: A specific substrate for type Bmonoamine oxidase of brain. J. Pharmacol. Exp. Ther. 187:365-371, 1973.

61. Neff, N.H., Yang, H.-Y.T. and Goridis C.: Degradation of the transmitter amines byspecific types of monoamine oxidases. In: Frontiers in Catecholamine Research,London, Pergamon Press, pp. 133-137, 1973.

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62. Goridis, C. and Neff, N.H.: Selective localization of monoamine oxidase in ratmesenteric artery. In: Frontiers in Catecholamine Research, London, Pergamon Press,pp. 157-160, 1973.

63. Garelis, E. and Neff, N.H.: Cyclic adenosine monophosphate: Selective increase incaudate nucleus after administration of L-DOPA. Science 183:532-533, 1973.

64. Neff, N.H., Yang, H.-Y.T., Goridis, C. and Bialek, D.: The metabolism ofindolalkylamines by type A and B monoamine oxidase of brain. Adv. in Biochem.Psychopharmacol. Vol. 11:51-58, 1974.

65. Neff, N.H., Yang, H.-Y.T., Garelis, E. and Sampath, S.S.: Biogenic amine containingneurons: Biochemical mechanisms of synaptic transmission. Psychother. Psychosom.23:159-168, 1974.

66. Neff, N.H. and Yang, H.-Y.T.: Another look at the monoamine oxidases and themonoamine oxidase inhibitor drugs. Life Sci. 14:2061-2074, 1974.

67. Sampath, S.S. and Neff, N.H.: The elimination of 5-hydroxyindoleacetic acid fromcerebrospinal fluid: Characteristics of the acid transport system of the choroid plexus.J. Pharmacol. Exp. Ther. 188:410-414, 1974.

68. Yang, H.-Y.T. and Neff, N.H.: The monoamine oxidases of brain: Selective inhibitionwith drugs and the consequences for the metabolism of the biogenic amines. J.Pharmacol. Exp. Ther. 189:733-740, 1974.

69. Neff, N.H., Yang, H.-Y.T. and Fuentes, J.A.: The use of selective MAO inhibitor drugsto modify amine metabolism in brain. Advances in Biochemical Psychopharmacol. Vol.12, New York, Raven Press, pp. 9-58, 1974.

70. Wyatt, R.J., Neff, N.H., Vaughn, T., Granz, J. and Omaya, A.: Ventricular fluid 5HIAAconcentrations during human sleep. In: Advances in Biochemical Psychopharmacology,Vol. II, New York, Raven Press, pp. 193-198, 1974.

71. Schwartz, M.A., Wyatt, R.J., Yang, H.-Y.T. and Neff, N.H.: Multiple forms of brainmonoamine oxidase in schizophrenic and normal individuals. Arch. Gen. Psychiatry31:557-560, 1974.

72. Garelis, E., Gillin, J.C., Wyatt, R.J. and Neff, N.H.: Elevated blood serotoninconcentrations in chronic, unmedicated schizophrenics: a preliminary study. Am. J.Psychiatry 132:184-186, 1975.

73. Fuentes, J.A., Oleshansky, M.A. and Neff, N.H.: A sensitive enzymatic assay for dextro-or levo-tranylcypromine in brain. Biochem. Pharmacol. 24:1971-1974, 1975.

74. Fuentes, J.A. and Neff, N.H.: Selective monoamine oxidase inhibitor drugs as aids inevaluating the role of type A and B enzymes. Neuropharm acol. 14:819-826, 1975.

75. Oleshansky, M.A. and Neff, N.H.: Rat pineal adenosine cyclic 3',5'-monophosphate

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phosphodiesterase activity: In vivo modulation by a beta-adrenergic receptor. Mol.Pharmacol. 11:552-557, 1975.

76. Neff, N.H. and Fuentes, J.A.: The use of selective monoamine oxidase inhibitor drugsfor evaluating pharmacological and physiological mechanisms. Ciba Symposium,39:163-172, 1976.

77. Fuentes, J.A., Oleshansky, M.A. and Neff, N.H.: A comparison of the apparentantidepressant activity of (-) and (+) tranyl-cypromine in an animal model. Biochem.Pharmacol. 25:801-804, 1976.

78. Yang, H.-Y.T. and Neff, N.H.: N-Acetyltransferase of brain: Some properties of theenzyme and the identification of beta-carboline inhibitor compounds. Mol. Pharmacol.12:69-72, 1976.

79. Oleshansky, M.A. and Neff, N.H.: On the mechanism of tolerance to isoproterenol-induced accumulation of cAMP in rat pineal in vivo. Life Sci. 17:1429-1432, 1975.

80. Sampath, S.S. and Neff, N.H.: Transport of 3-methoxy-4-hydroxy-mandelic acid byisolated rat choroid plexus. Neurochem. Res. 1:47-52, 1976.

81. Karoum, F., Neff, N.H. and Wyatt, R.J.: Distribution and turnover rate of vanillymandelic

acid and 3-methoxy-4-hydroxyphenylglycol in rat brain. J. Neurochem. 27:33-35, 1976.

82. Neff, N.H., Garrison, C.K., Seaborg, J.B., Fuentes, J. and Wyatt, R.J.: Trace Aminesand the Monoamine Oxidases. E. Usdin and M. Sandler, Marcel Dekker, Inc., p. 41-57,1976.

83. Yang, H.-Y.T. and Neff, N.H.: Hydroxyindole-o-methyltransferase: An immunochemicalstudy of the neuronal regulation of the pineal enzyme. Mol. Pharmacol. 12:433-439,1976.

84. Yang, H.-Y.T. and Neff, N.H.: Brain N-acetyltransferase substrate specificity, distributionand comparison with enzyme activity from other tissues. Neuropharmacol. 15:561-564,1976.

85. Wyatt, R.J., Cantor, F., Gillin, J., Gordon E., Karoum, F., McCullough, D., Neff, N.H.,Ommaya, A., Rauscher, F.P., Seaborg, J.B. and Slaby, A.: A ventricular fluidmetabolites and phenolicamines and catecholamines. In: Trace Amines and the Brain.E. Usdin and M. Sandler (eds.), Marcel Dekker, Inc., pp. 203-231, 1976.

86. Garrison-Gund, C.K. and Neff, N.H.: Deuterium-labeled choline: Lack of isotope effectsduring the synthesis and catabolism of acetylcholine in vivo. Neurochem. Res. 1:679-682, 1976.

87. Quenzer, L.F., Galli, C.L. and Neff, N.H.: Activation of the nigrostriatal dopaminergicpathway by injection of cholera enterotoxin into the substantia nigra. Science 195:78-80, 1977.

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88. Fuentes, J.A., Trepel, J.B. and Neff, N.H.: Monoamine oxidase activity in thecardiovascular system of young and aged rats. Exp. Geront. 12:113-115, 1977.

89. Karoum, F., Garrison, C.K., Neff, N.H. and Wyatt, R.J.: Trans-synaptic modulation ofdopamine metabolism in the rat superior cervical ganglion. J. Pharmacol. Exp. Ther.201:654-661, 1977.

90. Neff, N.H., Galli, C.L. and Costa, E.: The turnover of dopamine: Studies with O2. In:Advances in Biochemical Psychopharmacology, Vol. 16, New York, pp. 187-192, E.Costa and G.L. Gessa (eds.) Raven Press, 1977.

91. Galli, C.L., Commissiong, J.W. and Neff, N.H.: Measuring the formation of the biogenicamines utilizing O2. Biochem. Pharmacol. 26:1271-1273, 1977.

92. Trepel, J.B., Wyatt, R.J. and Neff, N.H.: Differential distribution of type A and Bmonoamine oxidase in neuronal tissues. Eur. J. Pharmacol. 43:373-375, 1977.

93. Fuentes, J.A. and Neff, N.H.: Inhibition by pargyline of cardiovascular amine oxidaseactivity. Biochem. Pharmacol. 26:2107-2112, 1977.

94. Karoum, F., Neff, N.H. and Wyatt, R.J. The dynamics of dopamine metabolism invarious regions of rat brain. Eur. J. Pharmacol. 44:311-318, 1977.

95. Neff, N.H., Commissiong, J.W., Galli, C.L., Iuvone, P.M., Garrison-Gund, C.K. andKaroum, F.: Mass spectrometry to measure regional aspects of dopamine metaoblismin structure and function of monoamine enzymes. In: Modern Pharmacology-Toxicology,Usdin, E., Weiner, N. and Youdim, M.B.H. (eds.), New York, Marcel Dekker, Inc., Vol.10, pp. 781-798, 1977.

96. Galli, C.L., Commissiong, J.W., Karoum, F., Neff, N.H. and Costa, E.: Measurement ofphenylalanine hydroxylating activity in vivo: O2-tyrosine in plasma after exposing rats toO2. Neurochem. Res. 2:657-669, 1977.

97. Trepel, J.B., Chuang, D.M. and Neff, N.H.: Transfer of ADP-ribose from NAD tocholeragen: A subunit acts as catalyst and acceptor protein. Proc. Natl. Acad. Sci.74:5440-5442, 1977.

98. Commissiong, J.W., Galli, C.L. and Neff, N.H.: Differentiation of dopaminergic andnoradrenergic neurons in rat spinal cord. J. Neurochem. 30:1095-1099, 1978.

99. Commissiong, J.W., Hellstrom, S.O. and Neff, N.H.: A new projection from locuscoeruleus to the spinal ventral columns: histochemical and biochemical evidence.Brain Res. 148:207-213, 1978.

100. Galli, C.L, Commissiong, J.W., Costa, E. and Neff, N.H.: Incorporation of O2 into brainserotonin in vivo as a procedure for estimating turnover rate: A feasibility study inanimals. Life Sci. 22:473-478, 1978.

101. Galli, C.L., Comm issiong, J.W . and Neff, N.H.: The use of stable oxygen isotopes and

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mass fragmentography for assessing enzyme activity: phenylamine hydroxylase in vivoIn: Recent Developments in Mass Spectrometry in Biochemistry and Medicine, Vol. I,Alberto Frigerio (ed.), Plenum Publ., New York, p. 243-251, 1978.

102. Oleshansky, M.A. and Neff, N.H.: Studies on the control of pineal indole synthesis:Cyclic nucleotides, adenylate cyclase and phosphodiesterase. Proceedings of theInternational on the Pineal Gland, Nir, I., Reiter, R.J. and Wurtman, R.J. (eds.) J. Neural.Trans. Suppl. 13:81-96, 1978.

103. Iuvone, P.M., Galli, G.L., Garrison-Gund, C.K. and Neff, N.H.: Light activates tyrosinehydroxylase and increases dopamine synthesis in retina amacrine neurons. Science202:901-902, 1978.

104. Neckers, L.M., Neff, N.H., Garrison-Gund, C.K. and Wyatt, R.J.: Increased adenylatecyclase activity and rapid weight loss following itraseptal injection of cholera toxin. Euro.J. Pharmacol. 51:141-144, 1978.

105. Iuvone, P.M., Galli, C.L. and Neff, N.H.: Retinal tyrosine hydroxylase: Comparison ofshort term and long term stimulation by light. Mol. Pharmacol. 14:1212-1219, 1978.

106. Karoum, F. and Neff, N.H.: Analysis of dopamine and its metabolites in biologicalmaterials by mass fragmentography. In: The Neurobiology of Dopamine, Horn, A.S.,Korf, J. and Westerink, B.H.C. (eds.) Academic Press, New York, pp. 63-76, 1979.

107. Commissiong, J.W. and Neff, N.H.: Current status of dopam ine in the mammalianspinal cord. A commentary in Biochem. Pharmacol. 28:1569-1573, 1979.

108. Commissiong, J.W., Gentleman, S. and Neff, N.H.: Spinal cord dopaminergic neurons:Evidence for an uncrossed nigrospinal pathway. Neuropharmacol. 18:565-568, 1979.

109. Commissiong, J.W. and Neff, N.H.: Dopaminergic and noreadrenergic neurons in spinalcord: Functional implications. In: Catecholamines: Basic and Clinical Frontiers (Proc.4th Int. Symposium on Catecholamines), Usdin, E., Kopin, I.H. and Barchas, J. (eds.)Vol. II, Pergamon Press, England, pp. 1339-1341, 1979.

110. Iuvone, P.M. and Neff, N.H.: Regional tyrosine hydroxylase: Stimulation in vivo by lightand in vitro by cAMP dependent protein phosphorylation conditions. In:Catecholamines: Basic and Clinical Frontiers Proc. 4th Int. Symposium onCatecholamines), Usdin, E., Kopin, I.H. and Barchas, J. (eds.) Vol. I, Pergamon Press,England, pp. 121-123, 1979.

111. Lutold, B.E., Karoum, F. and Neff, N.H.: Deficient dopamine metabolism in the celiacganglion of spontaneous hypertensive rats. Circul. Res. 44:467-471, 1979.

112. Lutold, B.E., Karoum, F. and Neff, N.H.: Activation of rat sympathetic ganglia SIF celldopamine metabolism by muscarinic agonists. Eur. J. Pharmaocl. 54:21-26, 1979.

113. Neckers, L.M., Neff, N.H. and Wyatt, R.J.: Increased serotonin turnover in striatumfollowing the injection of kainic acid: evidence for neuronal feedback regulation of

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synthesis. Naunyn Schmiedeberg's Arch. of Pharmacol. 306:173-177, 1979.

114. Neff, N.H., Lutold, B.E. and Karoum, F.: Deficient SIF cell dopamine metabolism inceliac ganglion of young spontaneously hypertensive rats (SHR) before the onset ofhypertension. In: Catecholamines: Basic and Clinical Frontiers (Proc. 4th Int.Symposium on Catecholamines), Usdin, E., Kopin, I.J. and Barches, J. (eds.) Vol. II,Pergamon Press, England, pp. 1452-1454, 1979.

115. Kayaalp, S.O. and Neff, N.H.: Muscarinic receptors of the rat adrenal medulla. Eur. J.Pharmacol. 57:255-258, 1979.

116. Iuvone, P.M., Joh, T.H. and Neff, N.H.: Regulation of retinal tyrosine hydroxylase: Long-term exposure to light increased the apparent Bmax without a concomitant increase ofimmunotitratable enzyme molecules. Brain Res. 178:191-195, 1979.

117. Fuentes, J.A., Ordaz, A. and Neff, N.H.: Central mediation of the antihypertensiveeffects of pargyline in spontaneously hypertensive rats. Eur. J. Pharmacol. 57:21-27,1979.

118. Kayaalp, S.O. and Neff, N.H.: Cholinergic muscarinic receptors of bovine adrenalmedulla. Neuropharmacology 18:909-912, 1979.

119. Karoum, F., Speciale, S.G., Jr. and Neff, N.H.: 3,4-Dihydroxy-phenylacetic acid(DOPAC) content of sympathetic ganglia as a possible biochemical indicator of SIF cellparticipation in ganglionic transmission. Biochem. Pharmacol. 29:118-119, 1980.

120. Neff, N.H., Gentleman, S., Parenti, M. and Commissiong, J.W.: Dopamine neurons ofspinal cord: A possible site for the action of neuroleptic drugs. In: Usdin, E., Sourkes,T.L. and Youdim, M.B.H. (eds.): Enzymes and Neurotransmitters in Mental Disease.John Wiley and Sons, Inc., pp. 37-43, 1980.

121. Karoum, F., Commissiong, J.W., Neff, N.H. and Wyatt, R.J.: Biochemical evidence foruncrossed and crossed locus coeruleus projections to the spinal cord. Brain Res.196:237-241, 1980.

122. Kayaalp, S.O. and Neff, N.H.: Regional distribution of cholinergic muscarinic receptorsin spinal cord. Brain Res. 196:429-436, 1980.

123. Kayaalp, S.O. and Neff, N.H.: Differentiation by ascorbic acid of dopamine agonist andantagonist binding sites in striatum. Life Sci. 26:1837-1842, 1980.

124. Lackovic, Z. and Neff, N.H.: Evidence for the existence of peripheral dopaminergicneurons. Brain Res. 193:289-292, 1980.

125. Iuvone, P.M. and Neff, N.H.: Dopamine neurons of retina: A simple model system forstudying synaptic regulatory mechanisms. In: Youdim, M.B.H., Lovenberg, W.,Sharman, P.F. and Lagnado, J.R. (eds.): Essays in Neurochemistry andNeuropharmacology. New York, John Wiley and Sons, Inc., Vol. 5, pp. 75-94, 1981.

126. Neff, N.H. and Neckers, L.M.: Evidence for neuronal feedback regulation of serotonin

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formation in brain. In: Haber, B., Gabay, S., Issidorides, M.R. and Alivisatos, S.G.A.(eds.) Advances in Experimental Medicine and Biology. Plenum Press, New York, pp.445-453, 1981.

127. Trepel, J.B., Chuang, D.-M. and Neff, N.H.: Polypeptide hormone and chromatinassociated proteins act as acceptors for cholera toxin catalyzed ADP-ribosylation. J.Neurochem. 36:538-543, 1981.

128. Commissiong, J.W., Karoum, F., Reiffenstein, R.J. and Neff, N.H.: Cyclobenzaprine: A

possible mechanism of action for its muscle relaxant effect. Can. J. Physiol. Pharmacol.59:37-44, 1981.

129. Karoum, F., Commiss iong, J.W., Neff, N.H. and Wyatt, R.J.: Regional differences incatecholamine formation and metabolism in the rat spinal cord. Brain Res. 212:361-366, 1981.

130. Gentleman, S., Parenti, M., Commissiong, J.W. and Neff, N.H.: Dopamine-activatedadenylate cyclase of spinal cord: Supersensitivity following transection of the cord. BrainRes. 210:271-275, 1981.

131. Lackovic, Z., Parenti, M. and Neff, N.H.: Simultaneous determination of femtomolequantities of 5-hydroxytryptophan, serotonin and 5-hydroxyindole-acetic acid in brainusing HPLC with electrochemical detection. Eur. J. Pharmacol. 69:347-352, 1981.

132. Parenti, M., Gentleman, S., Olianas, M.C. and Neff, N.H.: The dopamine receptorcomplex: Biochemical consequences of supersensitivity induced by treatment with 6-hydroxydopamine or morphine. In: Gessa, G.L. and Corsini, G.U. (eds.) Apomorphineand Other Dopaminomimetics, Vol. I, Basic Pharmacology. New York, Raven Press, pp.201-208, 1981.

133. Neff, N.H., Parenti, M., Gentleman, S. and Olianas, M.C.: Modulation of dopaminereceptors by opiates. In: Gessa, G.L. and Corsini, G.U. (eds.) Apomorphine and OtherDopaminomimetics, Vol. I, Basic Pharmacology. New York, Raven Press, pp. 193-200,1981.

134. Kayaalp, S.O., Rubenstein, J.S. and Neff, N.H.: Inhibition of dopamine D-1 and D-2binding sites in neuronal tissues by ascorbate. Neuropharmacol. 20:409-410, 1981.

135. Cohen, J., Iuvone, P.M. and Neff, N.H.: Neuroleptic drugs activate tyrosine hydroxylaseof retinal amacrine cells. J. Pharmacol. Exp. Ther. 218:390-394, 1981.

136. Lackovic, Z., Relja, M. and Neff, N.H.: Evidence for a peripheral dopaminergic neural

system. In: E. Usdin, N. Weiner, and M.B.H. Youdim (eds.) Function and Regulation ofMonoamine Enzymes: Basic and Clinical Aspects, MacMilan Publ. Ltd., London, pp.361-370, 1981.

137. Cohen, J. and Neff, N.H.: Neuroleptic drugs modify retinal dopamine-containingamacrine cell tyrosine hydroxylase activity. In: E. Usdin, N. Weiner and M.B.H. Youdim(eds.) Function and Regulation of Monoamine Enzymes: Basic and Clinical Aspects,

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MacMilan, London, pp. 55-64, 1981.

138. Neff, N.H. Parenti, M., Gentleman, S. and Olianas, M.C.: Treatment with 6-hydroxydopamine or morphine induces supersensitivity of the dopamine receptoradenylate cylcase complex. In: E. Usdin, N. Weiner and M.B.H. Youdim (eds.) Functionand Regulation of Monoamine Enzymes: Basic and Clinical Aspects, MacMilan Publ.Ltd., London, p. 803-808, 1981.

139. Wojcik, W., Olianas, M., Parenti, M., Gentleman, S. and Neff, N.H.: A simplefluorometric method for cAMP: Application to studies of brain adenylate cyclase act ivity.J. Cyclic Nucleotide Res. 7:27-35, 1981.

140. Lackovic, Z., Kleinman, J., Karoum, F. and Neff, N.H.: Dopamine and its metabolites inhuman peripheral nerves: Is there a widely distributed system of peripheraldopaminergic nerves? Life Sci. 29:917-922, 1981.

141. Olianas, M., Oliver, A.P. and Neff, N.H.: Biochemical and electrophysiologicla studieson the mechanism of action of typical and atypical antidepressants on the H2 histaminereceptor complex. In: E. Costa and G. Racagni (eds.) Typical and AtypicalAntidepressants: Molecular Mechanisms Advances in Biochemical andPsychopharmacology Vol. 31, Raven Press, New York, pp. 149-156, 1982.

142. Cohen, J. and Neff, N.H.: Retinal amacrine cell system tyrosine hydroxylase: Thedevelopment of responsiveness to light and neuroleptic drugs. Dev. Brain Res. 3:160-163, 1982.

143. Parenti, M., Gentleman, S., Olianas, M.C. and Neff, N.H.: The dopamine receptoradenylate cyclase complex: Evidence for post recognition site involvement for thedevelopment of supersensitivity. Neurochem. Res. 7:1455-1464, 1982.

144. Karoum, F. and Neff, N.H.: Quantitative gas chromatography-mass spectrometry (GC-MS) of biogenic amines: Theory and Practice. In: Spector, S. and Back, N. (eds).Modern Methods in Pharmacology, Vol. I, A.R. Liss, New York, pp. 39-54, 1982.

145. Lackovic, Z., Relja, M. and Neff, N.H.: Catabolism of endogenous dopamine inperipheral tissues: Is there an independent role for dopamine in peripheralneurotransmission? J. Neurochem. 38:1453-1458, 1982.

146. Cohen, J. and Neff, N.H.: Activation of retinal tyrosine hydroxylase: Tolerance inducedby chronic treatment with haloperidol does not modify response to light. J. Pharmacol.Exp. Ther. 221:326-328, 1982.

147. Wojcik, W.J. and Neff, N.H.: Adenosine measurements by a rapid HPLC-fluorometricmethod: Induced changes of adenosine content in regions of rat brain. J. Neurochem.39:280-282, 1982.

148. Iuvone, P.M., Rauch, A.L., Marshburn, P.B., Glass, D.B. and Neff, N.H.: Activation ofretinal tyrosine hydroxylase in vitro by cyclic AMP dependent protein kinase:Characterization and comparison to activation in vivo by photic stimulation. J.

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Neurochem. 39:1632-1640, 1982.

149. Hadjiconstantinou, M., Potter, P.E. and Neff, N.H.: Trans-synaptic modulation viamuscarinic receptors of serotonin-containing SIF cells of superior cervical ganglion. J.Neurosci. 2:1836-1839, 1982.

150. Relja, M., Lackovic, Z. and Neff, N.H.: Evidence for the presence of dopaminergicreceptors in vas deferens. Life Sci. 31:2571-2575, 1982.

151. Cohen, J., Hadjiconstantinou, M. and Neff, N.H.; Activation of dopamine-containingamacrine cells of retina: Light induced increase of acidic dopamine metabolites. BrainRes. 260:125-127, 1983.

152. Relja, M. and Neff, N.H.: Is dopamine a peripheral neurotransmitter? Fed. Proc.42:2998-2999, 1983.

153. Neff, N.H., Karoum, F. and Hadjiconstantinou, M.: Dopamine-containing small intenselyfluorescent (SIF) cells and sympathetic ganglion function. Fed. Proc. 42:3009-3011,1983.

154. Olianas, M.C., Onali, P., Neff, N.H. and Costa, E.: Adenylate cyclase activity of synaptic

membranes from rat striatum: Inhibition by muscarinic receptor agonists. Mol.Pharmacol. 23:393-398, 1983.

155. Lackovic, Z. and Neff, N.H.: Minireview: Evidence that dopamine is a neurotransmitterin peripheral tissues. Life Sci. 32:1665-1674, 1983.

156. Potter, P.E., Meek, J.L. and Neff, N.H.: Acetylcholine and choline in neuronal tissuemeasured by HPLC with electrochemical detection. J. Neurochem. 41:188-194, 1983.

157. Gentleman, S., Parenti, M., Neff, N.H. and Pert, C.B.: Inhibition of dopamine-activatedadenylate cyclase and dopamine binding by opiate receptors in rat striatum. Cellularand Molecular Neurobiology 3:17-26, 1983.

158. Wojcik, W.J. and Neff, N.H.: Adenosine A receptors are associated with cerebellargranule cells. J. Neurochem. 41:759-763, 1983.

159. Wojcik, W.J. and Neff, N.H.: Location of adneosine release adenosine A2 receptors torat striatal neurons. Life Sci. 33:755-763, 1983.

160. Olianas, M.C., Onali, P., Neff, N.H. and Costa, E.: Muscarinic receptors modulate

dopamine activated adenylate cyclase of rat striatum. J. Neurochem. 41:1364-1369,1983.

161. Hadjiconstantinou, M., Cohen, J. and Neff, N.H.: Epinephrine: A potentialneurotransmitter in retina. J. Neurochem. 41:1440-1444, 1983.

162. Wojcik, W.J. and Neff, N.H.: Differential location of Adenosine A1 and A2 receptors instriatum. Neurosci. Lett. 41:55-60, 1983.

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163. Neff, N.H.: Biogenic amines: An overview. In: Hanin, I. (eds.): Dynamics ofNeurotransmitter Function, New York, Raven Press, pp. 5-10, 1984.

164. Hadjiconstantinou, M. and Neff, N.H.: Ascorbic acid could be hazardous to yourexperiments: A commentary on dopamine receptor binding studies with speculation ona role for ascorbic acid in neuronal function. Neuropharmacol. 22:939-943, 1983.

165. Olianas, M., Oliver, A.P. and Neff, N.H.: Correlation of histamine-induced neuronalexcitability with activation of adenylate cyclase in the guinea pig hippocampus.Neuropharmacol. 23:1071-1074, 1984.

166. Neff, N.H., Hadjiconstantinou, M. and Lackovic, Z.: Dopamine: An endogenousperipheral neurotransmitter. In: Poste, G. and Crooke, S.T. (eds.): Dopamine ReceptorAgonists. New York, Plenum Publ. Corp., pp. 179-194, 1984.

167. Wojcik, W.J. and Neff, N.H.: GABAB receptors are negatively coupled to adenylatecyclase in brain and in the cerebellum these receptors may be associated with granulecells. Mol. Pharmacol. 25:24-28, 1984.

168. Olianas, M., Onali, P., Schwartz, J.P., Neff, N.H. and Costa, E.: The muscarinic receptoradenylate cyclase complex of rat striatum: Desensitization following chronic inhibitionof acetylcholinesterase activity. J. Neurochem. 42:1439-1443, 1984.

169. Hadjiconstantinou, M., Cohen, J., Rubenstein, J.R. and Neff, N.H.: An endogenousligand modulates dopamine-containing neurons of retina via alpha-2 adrenoceptors. J.Pharmacol. Exp. Ther. 229:381-385, 1984.

170. Potter, P.E., Hadjiconstantinou, M., Meek, J.L. and Neff, N.H.: Measurement ofacetylcholine turnover rate in brain: An adjunct to a simple HPLC method for choline andacetylcholine. J. Neurochem. 43:288-290, 1984.

171. Potter, P.E. and Neff, N.H.: Spinal cord acetylcholine content: The consequence oftransection or treatment with the neurotoxin 6-aminonicotinamide. Brain Res. 303:87-90, 1984.

172. Hadjiconstantinou, M., Panula, P., Lackovic, Z. and Neff, N.H.: Spinal cord serotonin:A biochemical and immunohistochemical study following transection. Brain Res.322:245-254, 1984.

173. Hadjiconstantinou, M., Mariani, A.P., Panula, P., Joh, T.H. and Neff, N.H.:Immunohistochemical evidence for epinephrine-containing retinal amacrine cells.Neuroscience 13:547-551, 1984.

174. Hadjiconstantinou, M. and Neff, N.H.: Catecholamine systems of retina: A model forstudying synaptic mechanisms. Life Sci. 35:1135-1147, 1984.

175. Eva, C., Hadjiconstantinou, M., Neff, N.H. and Meek, J.L.: Acetylcholine measurementby HPLC using an enzyme loaded post-column reactor. Anal. Biochem. 143:320-324,1984.

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176. Potter, P.E., Hadjiconstantinou, M., Rubenstein, J.R. and Neff, N.H.: Chronic treatmentwith diisopropylfluorophosphate increases dopamine turnover in the striatum of the rat.Eur. J. Pharmacol. 106:607-611, 1985.

177. Wojcik, W.J., Cavalla, D. and Neff, N.H.: Co-Localized adenosine A and GABABreceptors of cerebellum may share a common adenylate cyclase catalytic unit. J.Pharmacol. Exp. Ther. 232:62-66, 1985.

178. Cavalla, D. and Neff, N.H.: Photoaffinity labeling of GABAA receptor with [3H] muscimol.J. Neurochem. 44:916-921, 1985.

179. Cavalla, D. and Neff, N.H.: Chemical mechanisms for photoaffinity labeling of receptors.Biochem. Pharmacol. 34:2821-2826, 1985.

180. Cavalla, D., Hadjiconstantinou, M., Laird, H.E. II, and Neff, N.H.: Intra-cerebroventricularadministration of 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine (MPTP) and itsmetabolite 1-methyl-4-phenylpyridinium ion (MPP) decrease dopamine and increaseacetylcholine in the mouse neostriatum. Neuropharmacology 24:585-586, 1985.

181. Xu, J., Hadjiconstantinou, M. and Neff, N.H.: Exposure to light accelerates the formationof dopamine from exogenous L-DOPA in the rat retina. J. Ocul. Pharmacol. 1:177-181,1985.

182. Hadjiconstantinou, M., Cavalla, D., Anthopoulou, E., Laird II, H.E. and Neff, N.H.: N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine increases acetylcholine and decreasesdopamine in mouse striatum: Both responses are blocked by anticholinergic drugs. J.Neurochem. 45:1957-1959, 1985.

183. Neff, N.H. and Hadjiconstantinou, M.: Peripheral dopaminergic systems. In: Panula, P.,Paivarinta, H. and Soinila, S. (eds.) Neurohistochemistry: Modern Methods andApplications. Alan R. Liss, N.Y., pp. 465-476, 1986.

184. Hadjiconstantinou, M., Xu, J., Cavalla, D., Laird II, H.E. and Neff, N.H.: The Neurotoxicityof MPTP May Have a Cholinergic Component. In: MPTP-A Neurotoxin Producing aParkinsonian Syndrome. S.P. Markey, N. Castagnoli, Jr., A.J. Trevor and I.J. Kopin, eds.Academic Press, pp 481-485, 1986.

185. Hadjiconstantinou, M. and Neff, N.H.: Treatment with GM1 ganglioside increases rat

spinal cord indole content. Brain Research 366:343-345, 1986.

186. Neff, N.H., Hadjiconstantinou, M. and Papademetriou, J.C.: Peripheral dopaminergicsystems: Biochemistry, and Pharmacology. Modulation of Central and PeripheralTransmitter Function. Symposia in Neuroscience, Vol. 3, G. Biggio, P.F. Spano, G.Toffano, G.L. Gessa, eds. Liviana Press, 1986, pp 141.

187. Hadjiconstantinou, M., Rossetti, Z.L., Paxton, R.C. and Neff, N.H.: Administration ofGM1 ganglioside restores the dopam ine content in striatum after chronic treatment withMPTP. Neuropharm. 25:1075-1077, 1986.

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188. Hadjiconstantinou, M., J.C., Papademetriou and Neff, N.H.: Differentiation ofnoradrenergic and dopaminergic neurons in the cardiovascular system. Neurochem.International. 9:551-555, 1986.

189. Mariani, A.P., Neff, N.H. and Hadjiconstantinou, M.: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment decreases dopamine and increases lipofuscin inmouse retina. Neurosc i. Lett. 72:221-226, 1986.

190. Laird II, H.E., Hadjiconstantinou, M. and Neff, N.H.: III Abnormalities in the centralcholinergic transmitter system of the genetica lly epilepsy-prone rat. Life Sci. 39:783-787, 1986.

191. Hadjiconstantinou, M. and Neff, N.H.: Is Dopamine a Transmitter in the Periphery?Neuropharmacology 26:809-814, 1987.

192. Hadjiconstantinou, M., Tjioe, S.A., Alho, H., Miller, C. and Neff, N.H.: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) accelerates the accumulation of lipofuscin in mouseadrenal gland. Neurosci. Lett. 83:1-6, 1987.

193. Neff, N.H., Meek, J.L., Hadjiconstantinou, M. and Laird II, H.E.: Analysis of choline andacetylcholine in tissue by HPLC with electrochemical detection. In: Parvez, H., Parvez,S., Bastart-Malsot, M., Nagutsu, T., Bergstedt, L. and Pellesin, J. (eds): Progress inHPLC, Vol. 2: Electrochemical Detection in Medicine and Chemistry. Ultrecht, Holland,V.N.U. International Science Press, pp. 181-191, 1987.

194. Neff, N.H. and Hadjiconstantinou, M.: Catecholamine systems of the retina. Progressin Catecholamine Research, Part A: Basic Aspects and Peripheral Mechanisms, AlanR. Liss, pp. 485-490, 1988.

195. Neff, N.H., Qu, Z-X. and Hadjiconstantinou, M.: Retinal dopamine receptors:Pharmacology and functional interactions. Central and Peripheral Dopamine Receptors:Biochemistry and Pharmacology, Symposia in Neuroscience, Vol. 5, P.F. Spano, G.Biggio, G. Toffano and G.L. Gessa (eds) Liviana Press, pp 249-256, 1988.

196. Neff, N.H. and Hadjiconstantinou, M.: GM1 ganglioside restores striatal dopaminecontent in the MPTP mouse model of Parkinson's disease. New Trends in GangliosideResearch: Neurochemical and Neuroregenerative Aspects. Fidia Research Series, Vol.14, W.R. Ledeen, E.L. Hogan, G. Tettamanti, A.J. Yates and R.K. Yu (eds), LivianaPress, pp. 557-566, 1988.

197. Hadjiconstantinou, M., Qu, Z-X, Mariani, A.P. and Neff, N.H.: MPTP neurotoxicity andretinal dopaminergic neurons. Dopaminergic Mechanisms in Vision. I. Bodis-Wollnerand M. Poccolino (ed), Neurol and Neurobiol, Vol. 43, 193-203, Alan R. Liss Inc, NY,1988.

198. Qu, Z-X, Neff, N.H. and Hadjiconstantinou, M.: MPP+ depletes retinal dopamine andinduces D-1 receptor supersensitivity. Eur. J. Pharm. 148:453-455, 1988.

199. Hadjiconstantinou, M., Rossetti, Z.L. Krajnc, D. and Neff, N.H.: Aromatic L-amino acid

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decarboxylase activity of the rat retina is modulated in vivo by environmental light. J.Neurochem. 51:1560-1564, 1988.

200. Rossetti, Z., Sotgin, A., Sharp, D.E., Hadjiconstantinou, M. and Neff, N.H.: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and free radicals in vitro. Biochem. Pharm.37:4573-4574, 1988.

201. Hadjiconstantinou, M., Qu, Z-X., Moroi-Fetters, S.D. and Neff, N.H.: Apparent loss ofGi protein activity in the diabetic retina. Eur. J. Pharmacol. 149:193-194, 1988.

202. Qu, Z-X., Fertel, R., Neff, N.H. and Hadjiconstantinou, M.: Pharmacologicalcharacteristics of retinal muscarinic receptors mediating inhibition of adenylate cyclaseactivity in rat retina. J. Pharmacol. Exp. Ther. 246:839-842, 1988.

203. Moroi-Fetters, S.E., Neff, N.H. and Hadjiconstantinou, M.: Muscarinic receptor-mediatedphosphoinositide hydrolysis in the rat retina. J. Pharmacol. Exp. Ther. 246:553-557,1988.

204. Hadjiconstantinou, M. and Neff, N.H.: Treatment with GM1 ganglioside restoresdopamine in the 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine-treated mouse. J.Neurochem. 51:1190-1196, 1988.

205. Weihm uller, F.B., Hadjiconstantinou, M., Bruno, J.P. and Neff, N.H.: Administration ofGM1 ganglioside eliminates neuroleptic-induced sensorimotor deficits in MPTP-treatedmice. Neurosci. Lett. 92:207-212, 1988.

206. Qu, Z-X., Fertel, R., Neff, N.H. and Hadjiconstantinou, M.: Pharmacologicalcharacterization of rat retinal dopamine receptors. J. Pharm acol. Exp. Ther. 248:621-625, 1989.

207. Hadjiconstantinou, M. and Neff, N.H.: Determination of monoamine turnover by

blockade of their synthesis or metabolism, In: Neuromethods, Vol. 12: Drugs as Toolsin Neurotransmitter Research, ed. by A.B. Boulton, G.B. Baker and A.V. Juorio. HumanaPress, New Jersey, pp. 249-260, 1989.

208. Neff, N.H., Hadjiconstantinou, M., Moroi-Fetters, S.E., Qu, Z-X. and Fertel, R.:Neurochemical Pharmacology of Retina. Neurochemical Pharmacology, Tribute to B.B.Brodie. E. Costa (ed) Raven Press/N.Y., pp. 189-196, 1989.

209. Varol, F.G., Hadjiconstantinou, M., Zuspan, F.P. and Neff, N.H.: Angiotensin IIstimulates phosphoinositide turnover in the rat myometrium. Eur. J. Pharmacol. 162:37-42, 1989.

210. Hadjiconstantinou, M., Mariani, A.P. and Neff, N.H.: GM1 ganglioside-induced recoveryof nigrostriatal dopaminergic neurons after MPTP: An immunohistochemical study. BrainRes. 484:297-303, 1989.

211. Rossetti, Z.L., Krajnc, D., Neff, N.H. and Hadjiconstantinou, M.: Modulation of retinalaromatic L-amino acid decarboxylase via alpha-2 adrenoceptors. J. Neurochem. 52:647-

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652, 1989.

212. Varol, F.G., Hadjiconstantinou, M., Travers, J.B. and Neff, N.H.: Platelet activating factorstimulates phosphotidylinositol hydrolysis in the rat myometrium. Eur. J. Pharmacol.159:97-98, 1989.

213. Varol, F.G., Hadjiconstantinou, M., Zuspan, F.P. and Neff, N.H.: Pharmacologicalcharacterization of the muscarinic receptors m ediating phosphoinositide hydrolysis inthe rat myometrium. J. Pharmacol. Exp. Therap. 249:11-15, 1989.

214. Varol, F.G., Hadjiconstantinou, M., Zuspan, F. and Neff, N.H.: Gestational alterations inphospholipase C coupled muscarinic response. Life Sci. 45:1739-1743, 1989.

215. Hadjiconstantinou, M., Weihmuller, F. and Neff, N.H.: Treatment with GM1 gangliosidereverses dopamine D-2 receptor supersensitivity induced by the neurotoxin MPTP. Eur.J. Pharmacol. 168:261-264, 1989.

216. Weihmuller, F.B., Hadjiconstantinou, M., Bruno, J.P. and Neff, N.H.: Continued

administration of GM1 ganglioside is required to maintain recovery from neuroleptic-induced sensorimotor deficits in MPTP-treated mice. Life Sci. 45:2495-2502, 1989.

217. Moroi-Fetters, S.E., Neff, N.H. and Hadjiconstantinou, M.: Ethylcholine aziridium iondepletes acetylcholine and causes muscarinic receptor supersensitiv ity in rat retina.Neurosci. Lett. 109:304-308, 1990.

218. Rossetti, Z.L., Silvia, C.P., Krajnc, D., Neff, N.H. and Hadjiconstantinou, M.: AromaticL-amino acid decarboxylase is modulated by D1 dopamine receptors in rat retina. J.Neurochem. 54:787-791, 1990.

219. Hadjiconstantinou, M., Yates, A.J. and Neff, N.H.: Hypoxia-induced neurotransmitterdeficits in neonatal rats are partially corrected by exogenous GM1 ganglioside. J.Neurochem. 55:864:-869, 1990.

220. Weihmuller, F.B., Bruno, J.P., Neff, N.H. and Hadjiconstantinou, M.: Dopamine receptorplasticity following MPTP-induced nigrostriatal lesions in the mouse. Eur. J. Pharmacol.180:369-372, 1990.

221. Hadjiconstantinou, M., Weihmuller, F.B., Bruno, A.P., Mariani, A.P. and Neff, N.H.:Recovery of dopaminergic function following MPTP-induced neurodegeneration byexogenous GM1 ganglioside. In: Trophic Factors and the Nervous System. N.H. Neff,L. Horrocks, A.J. Yates and M. Hadjiconstantinou (eds), Raven Press, N.Y., pp. 293-305, 1990.

222. Neff, N.H. and Hadjiconstantinou, M.: Functional significance of central dopaminereceptors. In: Violence and Suicidality: Perspectives in Clinical and PsychobiologicalResearch ed. by van Praag, H.M., Plutchik, R. and Apter, A., Brunner/Mazel, New York,pp. 302-315, 1990.

223. Hadjiconstantinou, M. and Neff, N.H.: Differential recovery of dopamine synthetic

Neff, N.H. 21

enzymes following MPTP and the consequences of GM1 ganglioside treatment. Eur.J. Pharmacol. 181:137-139, 1990.

224. Hadjiconstantinou, M., Krajnc, D., Rossetti, Z. and Neff, N.H.: Modulation of dopaminemetabolism in the retina via dopamine D-2 receptors. Brain Res. 533:20-23, 1990.

225. Hadjiconstantinou, M., Moroi-Fetters, S.E., Qu, Z-X. and Neff, N.H.: Modulation ofmuscarinic receptor-mediated adenylate cyclase and phospholipase C response in ratretina. Cell. Mol. Neurobiol. 11:455-462, 1991.

226. Gudehithlu, K.P., Duchemin, A.M., Tejwani, G.A., Neff, N.H. and Hadjiconstantinou, M.:Preproenkephalin mRNA and methionine-enkephalin increase in mouse striatum afterMPTP treatment. J. Neurochem . 56:1043-1048, 1991.

227. Hadjiconstantinou, M., Qu, Z-X. and Neff, N.H.: Differential changes of retina dopaminebinding sites and adenylyl cyclase responses following 6-hydroxydopamine treatm ent.Brain Res. 538:193-195, 1991.

228. Gudehithlu, K.P., Duchemin, A.M., Dalia, D.A., Neff, N.H. and Hadjiconstantinou, M.:Age-related changes in the expression of the glutamate transporter from rat cerebralcortical poly A(+) mRNA in Xenopus Laevis oocytes. Neurochem. Int. 19:243-246, 1991.

229. Hadjiconstantinou, M., Fitkin, J.G., Dalia, A. and Neff, N.H.: Epidermal growth factorenhances striatal dopaminergic parameters in the MPTP-treated mouse. J. Neurochem.57:479-482, 1991.

230. Hadjiconstantinou, M., Karadsheh, N.S., Rattan, A.K., Tejwani, G.A., Fitkin, J.G. andNeff, N.H.: GM1 ganglioside enhances cholinergic parameters in the brain of senescentrats. Neuroscience 46:681-686, 1992.

231. Gudehithlu, K.P., Duchemin, A-M., Silvia, C.P., Neff, N.H. and Hadjiconstantinou, M.:Expression of cloned L-amino acid decarboxylase in Xenopus Laevis oocytes.Neurochem. Int. 21:275-279, 1992.

232. Duchemin, A-M., Gudehithlu, K.P., Neff, N.H. and Hadjiconstantinou, M.: c-fos mRNAin mouse brain after MPTP-treatment. Neurochem. Int. 20:281-287, 1992.

233. Hadjiconstantinou, M., Rossetti, Z.L., Sylvia, C.P., Krajnc, D. and Neff, N.H.: AromaticL-amino acid decarboxylase activity of retina is modulated via aminergic receptors. Neurochem. Int. 20; Suppl. 161-163S, 1992.

234. Hadjiconstantinou, M., Wemlinger, T.A., Silvia, C.P., Hubble, J. and Neff, N.H.:Aromatic L-amino acid decarboxylase activity of mouse striatum is modulated viadopaminergic receptors. J. Neurochem 60:2175- 2180, 1993.

235. Young, E.A., Neff, N.H. and Hadjiconstantinou, M.: Evidence for cyclic AMP-mediatedincrease of aromatic L-amino acid decarboxylase activity in the striatum and midbrain.J. Neurochem. Rapid Communication 60:2331-2333, 1993.

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236. Dalia, A., Neff, N.H. and Hadjiconstantinou, M.: GM1 ganglioside improvesdopaminergic markers of rat mesencephalic cultures treated with MPP+. J. Neurosci.13:3104-3111, 1993.

237. Gudehithlu, K.P., Neff, N.H. and Hadjiconstantinou, M.: c-fos and NGFI-A mRNA of ratretina: Evidence for light-induced augmentation and a role for cholinergic and glutamatereceptors. Brain Research 631:77-82, 1993.

238. Eaton, M.J., Gudehithlu, K.P., Quach, T., Silvia, C.P., Hadjiconstantinou, M. and Neff,N.H.: Distribution of aromatic L-amino acid decarboxylase mRNA in mouse brain by insitu hybridization histology. J. Comp. Neurol. 337:640-654, 1993.

239. Neff, N.H. and Hadjiconstantinou, M.: Trophic factors and GM1 ganglioside in the basalganglia. In: Trophic Regulation of the Basal Ganglia, Focus on Dopamine Neurons,eds. K. Fuxe, L.F. Agnati, B. Bjelke and D. Ottoson, Pergamon Press, 1994.

240. Young, E.A., Neff, N.H. and Hadjiconstantinou, M.: Phorbol ester administrationtransiently increases aromatic L-amino acid decarboxylase activity of the mousestriatum and midbrain. J. Neurochem. 63:694-697, 1994.

241. Hadjiconstantinou, M., Hubble, J.P., Wemlinger, T.A. and Neff, N.H.: Enhanced MPTPneurotoxicity following treatment with isoflurophate or cholinergic agonists. J.Pharmacol. Exp. Ther. 270:639-644, 1994.

242. Krajnc, D., Wemlinger, T.A., Neff, N.H. and Hadjiconstantinou, M.: Neonatal hypoxia:Early neurotransmitter responses and the consequences of treatment with GM1ganglioside. J. Pharmacol. Exp. Ther. 271:1299-1305, 1994.

243. Agius, L., Hadjiconstantinou, M., Qu, Z.-X., Neff, N.H., Pearl, D.K. and Yates, A.J.: GM1ganglioside and darkly staining neurons in brains of rats subjected to neonatal hypoxiaand ischemia. Int. Dev. Neurosci. 12:623-630, 1994.

244. Dhatt, R.K., Gudehithlu, K.P., Wemlinger, T.A., Tejwani, G.A., Neff, N.H. andHadjiconstantinou, M.: Preproenkephalin mRNA and methionine-enkephalin content areincreased in mouse striatum after treatment with nicotine. J. Neurochem. 64:1878-1883, 1995.

245. Hadjiconstantinou, M., Rossetti, Z., Wemlinger, T.A. and Neff, N.H.: Dizocilpineenhances striatal tyrosine hydroxylase and aromatic L-amino acid decarboxylaseactivity. Europ. J. Pharmacol. Molecular Pharmacology Section 289:97-101, 1995.

246. Fong, T.G., Neff, N.H. and Hadjiconstantinou, M.: Systemic administration of GM1ganglioside increases choline acetyltransferase activity in the brain of aged rats.Experimental Neurol. 132:157-161, 1995.

247. Fong, T.G., Vogelsberg, V., Neff, N.H. and Hadjiconstantinou, M.: GM1 and NGFsynergism on choline acetlytransferase and choline uptake in aged brain. Neurobiologyof Aging 16:917-923, 1995.

248. Neff, N.H. and Hadjiconstantinou, M.: Aromatic L-amino acid decarboxylase modulation

Neff, N.H. 23

and Parkinson’s disease. In: Progress in Brain Research Vol. 106. CurrentNeurochemical and Pharmacological Aspects of Biogenic Amines, Their Function,Oxidative Deamination and Inhibition. pp. 91-97, 1995. ed. by Yu, P.M., Tipton, K.F.and Boulton, A.A., Elsevier, N.Y., 1995.

249. Krajnc, D., Neff, N.H. and Hadjiconstantinou, M.: Glutame glutamine, and glutaminesynthetase in the neonatal rat brain following hypoxia. Brain Research 707:134-137,1996.

250. Copeland, B.J., Vogelsberg, V., Neff, N.H. and Hadjiconstantinou, M. : Protein kinaseC activators decrease dopamine uptake into striatal synatposomes. J. Pharmacol. Exp.Ther. 277:1527-1532, 1996.

251. Cho, S., Neff, N.H. and Hadjiconstantinou, M.: Modulation of tyrosine hydroxylase andaromatic L-amino acid decarboxylase after inhibition of monoamine oxidase-A. Eur. J.Pharmacol. 314:51-59, 1996.

252. Hadjiconstantinou, M., Neff, N.H., Zhou, L.-W. and Weiss, B.: D2 receptor antisenseincreases the activity and mRNA of tyrosine hydroxylase and aromatic L-amino aciddecarboxylase in mouse brain . Neurosci. Lett. 217:105-108, 1996.

253. Dalia, A., Neff, N.H. and Hadjiconstantinou, M.: Tyrosine hydroxylase and aromatic L-amino acid decarboxylase in mesencephalic cultures after MPP+: The consequencesof treatment with GM1 ganglioside. Brain Res. 742:260-264, 1996.

254. Vogelsberg, V., Neff, N.H. and Hadjiconstantinou, M.: Cyclic AMP-mediatedenhancement of high-affinity choline transport and acetylcholine synthesis in brain. J.Neurochem. 68:1062-1070, 1997.

255. Fong, T.G., Neff, N.H. and Hadjiconstantinou, M.: GM1 ganglioside improves spatiallearning memory of aged rats. Behav. Brain Res. 85:203-211, 1997.

256. Cho, S., Neff, N.H. and Hadjiconstantinou, M.: Regulation of tyrosine hydroxylase andaromatic L-amino acid decarboxylase by dopamine drugs. Eur. J. Pharmacol. 323:149-157, 1997.

257. Vogelsberg, V., Fong, T.G., Neff, N.H. and Hadjiconstantinou, M.: Cholinergic deficitsin the aged spinal cord. Restoration by GM1 ganglioside. Brain Res. 761:250-256,1997.

258. Duchemin, A.-M., Neff, N.H. and Hadjiconstantinou, M.: GM1 increases the content andthe mRNA of NGF in the brain of aged rats. NeuroReport 8:3823-3827, 1997.

259. Duchemin, A.M., Neff, N.H., Hadjiconstantinou, M.: Induction of Trk phosphorylation inrat brain by GM1 ganglioside. Ann. NY Acad. Sci. 845:406, 1998.

260. Hadjiconstantinou, M.. and Neff, N.H.: GM1 ganglioside: In vivo and in vitro trophicactions on central neurotransm itter systems. J. Neurochem. 70:1335-1345, 1998.

261. Hadjiconstantinou, M.. and Neff, N.H.: GM1 and the aged brain. Ann. N.Y. Acad. Sci.

Neff, N.H. 24

845:225-231, 1998.

262. Young, E.A., Duchemin, A.M., Neff, N.H. and Hadjiconstantinou, M.: Parallel modulationof striatal dopamine synthetic enzym es by second messenger pathways. Eur. J.Pharmacol. 357:15-23, 1998.

263. Goettl, V.M., Tejwani, G.A., Neff, N.H. and Hadjiconstantinou, M.: Decreasedneuropeptide content in the spinal cord of aged rats: The effects of GM1 ganglioside.NeuroReport 10:513-516, 1999.

264. Cho, S., Duchemin, A.M.., Neff, N.H. and Hadjiconstantinou, M.: Tyrosine hydroxylase,aromatic L-amino acid decarboxylase and dopamine metabolism after chronic treatmentwith dopaminergic drugs. Brain Res. 830:237-245, 1999.

265. Goettl, V.M., Wemlinger, T.A., Duchemin, A.-M., Neff, N.H. and Hadjiconstantinou, M.:GM1 ganglioside restores dopaminergic neurochemical and m orphological markers inaged rats. Neuroscience 92:991-1000, 1999.

266. Isola, R., Vogelsberg, V., Wemlinger, T.A., Neff, N.H. and Hadjiconstantinou, M.:Nicotine abstinence in the mouse. Brain Res. 850:189-196, 1999.

267. Neff, N.H., Wemlinger, T.A. and Hadjiconstantinou, M.: SCH 23390 enhancesexogenous L-DOPA decarboxylation in nigrostriatal neurons. J. Neural Transm.107:429-443, 2000.

268. Goettl, V.M., Lindsey, A.E., Neff, N.H. and Hadjiconstantinou, M.: GM1 gangliosiderestores abnormal responses to acute mechanical and thermal stimuli in aged rats.Brain Res. 858:380-385, 2000.

269. Hadjiconstantinou, M. and Neff, N.H.: GM1 gangliosides: Commonalities of action withneurotrophins. In: Neurotrophins. I. Mocchetti (ed). F.B. Graham Publishing TN, pp.495-521, 2000.

270. Duchemin, A.-M., Berry, M.D., Neff, N.H. and Hadjiconstantinou, M.: Phosphorylationand activation of brain aromatic L-amino acid decarboxylase by cyclic-AMP dependentkinase. J. Neurochem . 75:725-731, 2000.

271. Goettl, V.M., Wemlinger, T.A. Fong, T.G., Neff, N.H. and Hadjiconstantinou, M.: Retinalcholinergic and dopaminerg ic deficits of aged rats are improved following treatment withGM1 ganglioside. Brain Res. 877:1-6, 2000.

272. Varol, F.G., Duchemin, A.-M., Neff, N.H. and Hadjiconstantinou, M.: Nerve growth factor(NGF) and NGF mRNA change in rat uterus during pregnancy. Neurosci. Letters294:58-62, 2000.

273. Isola, R., Duchemin, A.-M., Tejwani, G.A., Neff, N.H. and Hadjiconstantinou, M.:Glutamate receptors participate in the nicotine-induced changes of met-enkephalin instriatum. Brain Res. 878:72-78, 2000.

274. Neff, N.H., Wemlinger, T.A., Hadjiconstantinou, M.: SCH 23390 enhances exogenous

Neff, N.H. 25

L-DOPA decarboxylation in nigrostriatal neurons. J. Neural Transm. 107:429-443, 2000.

275. Goettl, V.M., Wemlinger, T.A., Colvin, A.E., Neff, N.H., Hadjiconstantinou, M.: Motoricbehavior in aged rats treated with GM1. Brain Res. 906:92-100, 2001.

276. Duchemin, A.-M., Ren, Q., Mo,L., Neff, N.H. Hadjiconstantinou, M. GM1 gangliosideinduces phosphorylation and activation of Trk and Erk in brain. J. Neurochem.81:696-707, 2002.

277. Isola, R. Zhang, H., Duchemin, A.-M., Tejwani, G.A., Neff, N.H., Hadjiconstantionu, M.Met-Enkephalin and preproenkephalin mRNA changes in the striatum of the nicotineabstinence mouse. Neurosci. Lett. 325:67-71, 2002.

278. Podell, M., Hadjiconstantinou, M., Smith, M.A. and Neff, N.H. Proton magnetic resonanceimaging and spectroscopy identify metabolic changes in the striatum in the MPTP felinemodel of Parkinsonism. Exptl. Neurol. 179: 159-166, 2003.

279. Goettl, V.M., Zhang, H., Burrows, A.C., Wemlinger, T.A., Neff, N.H. andHadjiconstantinou, M. GM1enhances dopaminergic markers in brain of aged rats. Exptl.Neurol. Submitted. 2003.

280. Goettl, V.M., Neff, N.H. and Hadjiconstantinou, M. Sciatic nerve axotomy in aged rats:response of motoneurons and the effect of GM1 ganglioside treatment. Brain Res. Inpress. 2003.

ABSTRACTS

1. Neff, N.H. and Rabinowitz, J.L.: Vitamin E and muscle membranes. Fed. Proc. 21:315,1962.

2. Neff, N.H. and Rossi, G.V.: Distribution and metabolism of mescaline-14C in the catbrain. Fed. Proc. 22:335, 1963.

3. Tozer, T.N., Neff, N.H., Brodie, B.B.: Indole metabolism, Part I. A new kinetic approachto the determination of the synthesis rate of serotonin in the brain. The Pharmacologist6:194, 1964.

4. Neff, N.H., Tozer, T.N., Brodie, B.B.: Indole metabolism, Part II. A specialized transportsystem to transfer 5HIAA directly from brain to blood. The Pharmacologist 6:194, 1964.

5. Hammer, W.M., Neff, N.H., Tozer, T.N.: Kinetics of norepinephrine release. Fed. Proc.24:514, 1965.

6. Neff, N.H. and Costa, E.: A study of the control of catecholamine synthesis. Fed. Proc.25:259, 1966.

7. Costa, E. and Neff, N.H.: Properties of endogenous NE stores in hearts of rats given

Neff, N.H. 26

tracer doses of HNE. Proc. of III Int'l. Pharmacol. Congress, Sao Paulo, Brazil, No. 305,p. 121, 1966.

8. Neff, N.H. and Costa, E.: Effects of chlorpromazine, desipramine and proptriptyline onbrain catecholamine synthesis. The Pharmacologist 8:189, 1966.

9. Neff, N.H. and Costa, E.: The effect of oxygen on the turnover rate of biogenic aminesin vivo. I: Catecholamines (CA) Fed. Proc. 26:463, 1967.

10. Stern, D.N., Fieve, R., Neff, N. and Costa, E.: The effect of lithium on the turnover ofbrain and heart catecholamines. The Pharmacologist 9:210, 1967.

11. Neff, N.H., Barrett, R.E. and Costa, E.: Compartmentation of serotonin (5HT) in ratpineal. Fed. Proc. 27:288, 1968.

12. Lin, R.C., Costa, E., Neff, N.H. and Ngain, S.H.: A new isotopic method to estimate brainserotonin (5HT) turnover rate: effect of LSD on brain 5HT turnover rate. Fed. Proc.28:277, 1969.

13. Neff, N.H. and Spano, P.F.: Kinetics of chlorpromazine-9-3H and trifluoperazine-9-3Hdecline from brain and other tissues. Fed. Proc. 28:614, 1969.

14. Neff, N.H., Gropetti, A. and Spano, P.F.: Calculation of the turnover rate of brainserotonin after a pulse injection of radioactive tryptophan. Fed. Proc. 29:747, 1970.

15. Goridis, C. and Neff, N.H.: Monoamine oxidase: Approximation of turnover rates in brainand peripheral tissues of rat. Fed. Proc. 30:382, 1971.

16. Meek, J. and Neff, N.H.: Tryptophan hydroxylase: Rates of synthesis and axonaltransport. The Pharmacologist 13:266, 1971.

17. Goridis, C. and Neff, N.H.: Evidence for a specific monoamine oxidase in sympatheticnerves. Transactions of the Am. Soc. Neurochem. 2:74, 1971.

18. Neff, N.H. and Meek, J.L.: Modulation of catecholamine synthesis in vivo. Trans. of theAm. Soc. for Neurochem. 3:42, 1972.

19. Meek, J.L. and Neff, N.H.: Transport from brain of anionic norepinephrine metabolites.Fed. Proc. 31:602, 1972.

20. Meek, J.L. and Neff, N.H.: Fluorimetric measurement of 3-methoxy,4-hydroxphenylglycolsulfate (MOPEG-SO) as an estimate of norepinephrine turnover in brain. Fifth Int'l.Congress on Pharmacology, Volunteer Abstracts, 155, 1972.

21. Yang, H.-Y.T. and Neff, N.H.: Monoamine Oxidase: I. A natural substrate for type Benzyme. Fed. Proc. 32:797, 1973.

22. Neff, N.H. and Yang, H.-Y.T.: Monoamine Oxidase: II. Evaluation of the physiologicalrole of type A and B enzyme of brain. Fed. Proc. 32:797, 1973.

Neff, N.H. 27

23. Sampath, S.S. and Neff, N.H.: The elimination of 5-hydroxyindole- acetic acid (5H1AA)from cerebrospinal fluid: Characteristics of the acid transport system of the choroidplexuses. The Pharmacologist 15:258, 1973.

24. Neff, N.H., Yang, H.-Y.T. and Coridis, C.: Degradation of the transmitter amines byspecific types of monoamine oxidase. Life Sci. 13:cxxiv-cxxv, 1973.

25. Garelis, E. and Neff, N.H.: Cyclic adenosine 3',5'-monophosphate selective increase inthe rat striautm following the administration of L-DOPA. Program and Abstracts ThirdAnnual Meeting, Society for Neuroscience, 214, 1973.

26. Sampath, Khanna S. and Neff, N.H.: Transport of 3-methoxy-4-hydroxy-mandelic acidby the rat choroid plexus in vitro. Fed. Proc. 33:498, 1974.

27. Yang, H.-Y.T. and Neff, N.H.: N-acetyltransferase activity of brain. The Pharmacologist16:199, 1974.

28. Yang, H.-Y.T. and Neff, N.H.: Hydroxyindole-o-methyltransferase: Regulation of enzymeprotein level or enzyme activity by environmental lighting and sympathetic nerve activity.Fed. Proc. 34:243, 1975.

29. Fuentes, J.E. and Neff, N.H.: Selective monoamine oxidase inhibitor drugs: potentialtools for studying the role of the various enzymes. Fed. Proc. 34:778, 1975.

30. Oleshansky, M.A. and Neff, N.H.: Rat pineal cyclic nucleotide phosphodiesteraseactivity: in vivo modulation by a beta adrenergic receptor. Proc. of the Am. Soc.Neurochem. 6:9, 1975.

31. Oleshansky, M.A. and Neff, N.H.: In vivo activation of rat pineal cAMPphosphodiesterase by isoproterenol. Sixth Int'l. Con. Pharmacol. 688, 1975.

32. Karoum, F., Neff, N.H. and Wyatt, R.J.: A comparison of the regional brain distributionand estimated whole brain turnover rate of vanillymandelic acid (VMA) and 3-methoxy-4-hydroxy-1phenylglycol (MHPG). Neurosci. Abs., 5th Annual Meeting, Soc. for Neurosci.299, 1975.

33. Neff, N.H., Karoum, F. and Wyatt, R.J.: The dynamics of dopamine metabolism invarious regions of rat brain. Fed. Proc. 35:486, 1976.

34. Commissiong, J.W., Galli, C.L. and Neff, N.H.: Evidence for dopaminergic neurons inspinal cord. Fed. Proc. 36:952, 1977.

35. Galli, C.L., Commissiong, J.W. and Neff, N.H.: The use of 02 to estimate phenylalaninehydroxylase activ ity in vivo. Proc. Am. Soc. Neurochem. 8:226, 1977.

36. Iuvone, P.M., Galli, C.L., Garrison-Gund, C.K. and Neff, N.H.: Retinal tyrosinehydroxylase and dopamine turnover: Light-dark differences. Proc. Am. Soc.Neurochem. 8:96, 1977.

37. Commissiong, J.W., Hellstrom, S. and Neff, N.H.: Evidence for a noradrenergic

Neff, N.H. 28

coerulospinal projection in the rat. Proc. Am. Soc. Neurochem. 9:194, 1978.

38. Iuvone, P.M., Galli, C.L. and Neff, N.H.: Regulation of retinal tyrosine hydroxylase anddopamine metabolism by light. Proc. Am. Soc. Neurochem. 9:127, 1978.

39. Trepel, J.P., Chuang, D.-M. and Neff, N.H.: ACP-ribosyltransferase activity ofcholeragen: Choleragen A subunit and some peptide hormones act as acceptorproteins. Fed. Proc. 37:798, 1978.

40. Iuvone, P.M. and Neff, N.H.: Activation of retinal tyrosine hydroxylase by light andhaloperidol. Fed. Proc. 37:835, 1978.

41. Lutold, B.E., Karoum, F. and Neff, N.H.: Abnormal dopam ine metabolism in the celiacganglion SIF cells of young spontaneously hypertensive rats (SHR). Fed. Proc. 37:382,1978.

42. Lutold, B.E., Karoum, F. and Neff, N.H.: Dynamics of catecholamine metabolism in ratsympathetic ganglia. Proc. Am. Soc. Neurochem. 9:194, 1978.

43. Neff, N.H., Commissiong, J.W. and Karoum, F.: Mass fragmentographic analysis ofdopamine and its metabolites in neuronal tissues. Am. Chem. Soc. Metrochem. 78:2,1978.

44. Trepel, J.B., Neckers, L.M., Chuang, D.-M. and Neff, N.H.: Mouse fibroblast interferoncatalyzes proten ADP-Ribosylation. The Pharmacologist 21:213, 1979.

45. Parenti, M., Gentleman, S., Commissiong, J.W. and Neff, N.H.: Dopamine stimulatedadenylate cyclase in rat spinal cord: Supersensitivity after section of the cord. Fed.Proc. 38:746, 1979.

46. Kayaalp, S.O. and Neff, N.H.: Adrenal muscarinic receptors: Enhanced QNB bindingafter denervation. Proc. Am. Soc. Neurochem. 10:224, 1979.

47. Gentleman, S., Parenti, M., Commissiong, J.W. and Neff, N.H.: Dopamine-activatedadenylate cyclase in spinal cord. XIth Int'l. Congress Biochem. Abs. 561, 1979.

48. Iuvone, P.M. and Neff, N.H.: Regulation of retinal tyrosine hydroxylase: Long-termexposure to light increased the apparent Vmax without a concomitant increase ofenzyme molecules. Soc. for Neurosci. Abs. 5:338, 1979.

49. Commissiong, J.W., Karoum, F. and Neff, N.H.: Cyclobenzaprine: Action on thedecending coerulospinal noradrenergic projection. Soc. For Neurosci. Abs. 5:720, 1979.

50. Kayaalp, S.O. and Neff, N.H.: Regional distribution of muscarinic receptors in spinalcord. Soc. for Neurosci. Abs. 5:725, 1979.

51. Iuvone, P.M. and Neff, N.H.: Activaton of retinal tyrosine hydroxylase by light and bycAMP and ATP. Transaction Am. Soc. Neurochem. 11:140, 1980.

52. Lackovic, Z. and Neff, N.H.: Biochemical evidence for peripheral dopaminergic neurons.

Neff, N.H. 29

Trans. Am. Soc. Neurochem. 11:216, 1980.

53. Parenti, M., Gentleman, S. and Neff, N.H.: Modulation by opiates of dopamine-stimulateadenylate cyclase in rat striatum. Fed. Proc. 39:516, 1980.

54. Iuvone, P.M., Marshburn, P.B. and Neff, N.H.: Regulation of tyrosine hydroxylase activityin whole retina, retina cell suspensions and retinal homogenates. Soc. Neurosci. Abs.10:143, 1980.

55. Olianas, M., Oliver, A.P. and Neff, N.H.: Histamine stimulated adenylate cyclase activitycorrelates with increased neuronal excitability of the hippocampus. Fed. Proc. 40:314,1981.

56. Cohen, J. and Neff, N.H.: Haloperidol fails to activate retinal tyrosine hydroxylase inchronic drug treated animals. The Pharmacologist 23;137, 1981.

57. Olianas, M.C., Oliver, A.P. and Neff, N.H.: Chronic antidepressant treatment producessupersensitivity to the electrophysiological response of histamine in guinea pighippocampus without a change in the sensitivity of the histamine sensitive adenylatecyclase. Soc. Neurosci. Abs. 7:818, 1981.

58. Wojcik, W., Olianas, M.C., Parenti, M., Gentleman, S. and Neff, N.H.: AnHPLC/fluorometric method for cAMP. The Pharmacologist 23:185, 1981.

59. Lackovic, Z., Relja, M., Kleinman, J. and Neff, N.H.: Is there dopaminergic innervationof the reproductive system? Am. Soc. Neurochem. 12th Annual Meeting, pp. 196,1981.

60. Wojcik, W.J. and Neff, N.H.: Evidence that adenosine-containing neurons andadenosine sensitive cyclase are present in striatum. Fed. Proc. 41:1471, 1982.

61. Olianas, M.C., Onali, P., Neff, N.H. and Costa, E.: Inhibition of striatal adenylate cyclaseactivity by stimulation of muscarinic receptors. Fed. Proc. 41:1471, 1982.

62. Hadjiconstantinou, M., Potter, P. and Neff, N.H.: Preganglionic cholinergic neuronsmodulate serotonin-storing SIF cells of the rat superior cervical ganglion. Fed. Proc.41:1765, 1982.

63. Olianas, M., Onali, P., Neff, N.H. and Costa, E.: Acetylcholine inhibits dopamine-sensitive adenylate cyclase of rat striatum. Soc. Neurosci. Abs. 8:120, 1982.

64. Potter, P.E., Meek, J.L. and Neff, N.H.: Simultaneous determination of acetylcholine andcholine in neuronal tissue by HPLC with electrochemical detection. Soc. Neurosci. Abs.8:517, 1982.

65. Cohen, J., Hadjiconstantinou, M. and Neff, N.H.: Identification of epinephrine in the ratretina and its possible physiological implications. Pharmacologist 24:243, 1982.

66. Wojcik, W.J. and Neff, N.H.: Characteristics of the adenosine inhibited adenylatecyclase A receptor in rat and mouse cerebellum. Soc. Neurosci. Abs. 8:169, 1982.

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67. Hadjiconstantinou, M., Panula, P., Lackovic, Z. and Neff, N.H.: Biochemical andimmunohistochemical study of spinal cord serotonergic neurons. Fed. Proc. 42:1149,1983.

68. Neff, N.H., Hadjiconstantinou, M. and Cohen, J.: Catecholamines of retina: Evidencethat epinephrine may be a neurotransmitter. 5th Catecholamine Symposium Abs.Goteborg, Sweden, pp. 234, 1983.

69. Olianas, M.C., Onali, P., Neff, N.H. and Costa, E.: Dopamine- activated adenylatecyclase of striatum: Modulation by muscarinic receptors. 5th CatecholamineSymposium Abs., Goteborg, Sweden, pp. 239, 1983.

70. Neff, N.H.: The retina: A model for studying synaptic biochemical pharmacology.Pharmacologist 25:149, 1983.

71. Wojcik, W.J. and Neff, N.H.: GABA-B receptors inhibit adenylate cyclase activity ofbrain. Pharmacologist 25:166, 1983.

72. Hadjiconstantinou, M., Cohen, J., Rubenstein, J.S. and Neff, N.H.: Alpha-2adrenoreceptors modulate dopam ine metabolism in retina. Pharmacologist 25:194,1983.

73. Potter, P.E. and Neff, N.H.: Distribution of acetylcholine (ACh) in rat spinal cord.Pharmacologist 25:221, 1983.

74. Wojcik, W.J. and Neff, N.H.: Adenosine A and GABA-B receptors may share commonpost-recognition site elements of the adenylate cyclase complex. Soc. Neurosci. Abs.9:800, 1983.

75. Hadjiconstantinou, M., Mariani, A.P., Panula, P. and Neff, N.H.: Dopamine andepinephrine are contained in separate amacrine cells in rat retina. Soc. Neurosci. Abs.9:1127, 1983.

76. Hadjiconstantinou, M., Mariani, A.P., Panula, P., Joh, T.H. and Neff, N.H.: Epinephrine-containing amacrine cells in a mamm alian retina. Invest. Ophthalmol. Vis. Sci. Suppl.25:283, 1984.

77. Wojcik, W., Cavalla, D. and Neff, N.H.: Adenosine A and GABAB receptors areassociated with similar striatal neurons. Fed. Proc. 43:285, 1984.

78. Hadjiconstantinou, M., Rubenstein, J.S., Anthopoulou, H. and Neff, N.H.: Vasculardopamine and norepinephrine are located in separate neuronal elements. Fed. Proc.43:539, 1984.

79. Cavalla, D. and Neff, N.H.: Photoaffinity labeling of the GABAA receptor with 3H-muscimol. Fed. Proc. 43:541, 1984.

80. Cavalla, D., Wojcik, W .J. and Neff, N.H.: Monitoring membrane potentials inneuroblastoma x glioma NG-108 cells with a fluorescent dye. Soc. Neurosci. Abst.

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81. Hadjiconstantinou, M., Cavalla, D., Anthopoulou, H., Laird II, H.E. and Neff, N.H.: Thetoxicity of MPTP (N-methyl-4-phenyl- 1,2,3,6-tetrahydropyridine) on nigrostriataldopaminergic neurons can be blocked by pretreatment with anti-cholinergic drugs.Annual Meeting Am. Coll. Neuropsychopharmacol. pp. 99, 1984.

82. Neff, N.H., Hadjiconstantinou, M. and Cavalla, D.: MPTP and its metabolite MPP+ aswell as several structural analogs decrease neostriatal dopamine. Fed. Proc. 44: 893,1985.

83. Hadjiconstantinou, M., Cavalla, D., Anthopoulou, H., Laird II, H.E. and Neff, N.H.:Cholinergic mechanisms may be involved in the neurotoxicity of 2-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Fed. Proc. 44:892, 1985.

84. Xu, J., Hadjiconstantinou, M. and Neff, N.H.: Formation of dopamine in rat retinaadministered L-DOPA is accelerated by exposure to light. Pharmacologist 27:139,1985.

85. Hadjiconstantinou, M. and Neff, N.H.: GM ganglioside treatment changes indole andcatechol metabolism in spinal cord after hemitransection. Pharmacologist 27:124, 1985.

86. Hadjiconstantinou, M., Xu, T., Cavalla, D., Laird, H.E. and Neff, N.H.: The neurotoxicityof MPTP may have a cholinergic component. Symposium on MPTP (Abst). pp 51, 1985.

87. Neff, N.H., Mariani, A. and Hadjiconstantinou, M.: Chronic treatment of mice with MPTPresults in a decrease of retinal dopamine and the appearance of lipofuschin-likematerial. Soc. for Neurosci., Abs. 11:427, 1985.

88. Neff, N.H., Hadjiconstantinou, M. and Papademetriou, J.C.: Peripheral dopaminergicsystems: Biochemistry and Pharmacology. 4th Capo Bio Conference on Neuroscience(Abst) pp 105, 1985.

89. Coffman, J.A., Barfknecht, C.F., Neff, N.H., Hunter, W. and Dunn, V.: Benzodiazepinereceptor site imaging by magnetic resonance techniques. Am.CollegeNeuropsychopharmacol. Annual Meeting, Dec. 1985. Abst., pp 176.

90. Hadjiconstantinou, M., Alho, H., Tjioe, S., Paxton, R., Miller, C. and Neff, N.H.: MPTPalters adrenal catecholamines and causes the appearance of lipofuschin. AmericanSociety for Neurochemistry, 1986.

91. Neff, N.H., Alho, H., Tjioe, S., Paxton, R. and Hadjiconstantinou, M.: MPTP depletescatecholamines and causes the appearance of lipofuschin in mouse adrenal gland.Fed. Proc. 45:402, 1986.

92. Laird, H.E., II, Hadjiconstantinou, M. and Neff, N.H.: Abnormalities in the centralcholinergic transmitter system of the genetically epi lepsy prone rat (GEPR-9). Fed.Proc., 45:675, 1986.

93. Sharp, D.E., Ali, I.I., Hadjiconstantinou, M., Keller, P.J., Hunter, W.W. and Neff, N.H.: 1-Methyl-4-Phenyl-1,2,3,6-tetrahydropyridine (MPTP) produces lesions in the substantianigra of the cat which are visible by nuclear magnetic resonance imaging (MRI). Fed.

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Proc. 45:805, 1986.

94. Hadjiconstantinou, M. and Neff, N.H.: Light increases aromatic L-amino aciddecarboxylase activity in rat retina. Fed. Proc. 45:1064, 1986.

95. Hadjiconstantinou, M., Rossetti, Z. and Neff, N.H.: Aromatic L-amino decarboxylase is

modulated by alpha-2 adrenoreceptors in rat retina. The Pharmacologist 28:135, 1986.

96. Rossetti, Z., Neff, N.H. and Hadjiconstantinou, M.: Aromatic L-amino aciddecarboxylase activity is increased by dopamine D1 receptor blockade in rat retina. Soc.Neurosci. 12:601, 1986.

97. Rossetti, Z., Neff, N.H. and Hadjiconstantinou, M.: Aromatic L-amio acid decarboxylaseactivity is modulated by D1 dopamine receptor in rat retina. The Pharmacologist 28:134,1986.

98. Coffman, J.A., Barfknecht, C.F., Hunter, W., Chakers, D., Neff, N., Dunn, V. andKleeman, B.: Benzodiazepine Receptor Studies by MRI. Soc. Neurosci. 12:655, 1986.

99. Hadjiconstantinou, M., Rossetti, Z., Paxton, R.C. and Neff, N.H.: Aromatic L-amino aciddecarboxylase of retina enhanced by exposure to light. Soc. Neurosci. 12:601, 1986.

100. Qu, Z-X, Neff, N.H., Fertel, R. and Hadjiconstantiou, M.: Activation of retinal D-2receptors inhibits adenylate cyclase activity. Fed. Proc. 46:392, 1987.

101. Hadjiconstantinou, M., Qu, Z-X, Fertel, R. and Neff, N.H.: Muscarinic receptor arecoupled to an inhibitory adenylate cyclase system in the rat retina. Fed. Proc. 46:392,1987.

102. Neff, N.H. and Hadjiconstantiou, M.: Functional significance of central dopaminereceptors. In regulation of aggression. Amer. College of Neuropsychopharmacol. 25thAnnual Meeting, Abstract 119, 1986.

103. Neff, N.H., Qu, Z-X and Hadjiconstantinou, M.: Retinal dopamine receptors:pharmacology and functional interactions. In similarities and diss imilarities betweencentral and peripheral dopamine receptors. 5th Capo Boi Conference on Neuroscience,Abstract 116, 1987.

104. Hadjiconstantinou, M., Rossetti, Z.L. and Neff, N.H.: Modulation of retinal aromatic L-amino acid decarboxylase by light. 5th Capo Boi Conference on Neuroscience, Abstract179, 1987.

105. Rossetti, Z.L., Neff, N.H. and Hadjiconstantinou, M.: Dopamine D2 receptor blockadeincreases aromatic L-amino acid decarboxylase activity but fails to increase L-Dopasynthesis in rat retina. 5th Capo Boi Conference on Neuroscience, Abstract 180, 1987.

106. Neff, N.H. and Hadjiconstantinou, M.: GM1-induced recovery of striatal dopamine in theMPTP mouse model of Parkinsonism. New Trends in Ganglioside Research:Neurochemical and Neurogenerative Aspects. Satellite Symposium of ISN-ASN JointMeetings, Abstract 45, 1987.

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107. Hadjiconstantinou, M., Qu, Z-X, Rossetti, Z.L. and Neff, N.H.: Functional significanceof dopamine receptors in rat retina. J. Neurochem. 48:598, 1987.

108. Neff, N.H., Rossetti, Z.L. and Hadjiconstantinou, M.: Modulation of aromatic-L-aminoacid decarboxylase (AAAD). 6th International Catecholamine Symposium, Abstract 67,1987.

109. Hadjiconstantinou, M. and Neff, N.H.: GM1 ganglioside restores striatal dopaminecontent after MPTP treatment. 6th International Catecholamine Symposium, Abstract122, 1987.

110. Rossetti, Z.L., Sotgin, A., Sharp, D., Hadjiconstantinou, M. and Neff, N.H.: MPTP andgeneration of free radicals: A possible mechanism of neurotoxicity. Neurosci. Suppl. toVol 22: pp 560, 1987.

111. Hadjiconstantinou, M., Mariani, A.P. and Neff, N.H.: MPTP neurotoxicity and retinal

dopaminergic neurons. Neurosci. Suppl to Vol. 22: pp S204, 1987.

112. Hadjiconstantinou, M., Rossetti, Z. and Neff, N.H.: Light modulates aromatic L-aminoacid decarboxylase activity in rat retina. Neurosci. Suppl. to Vol. 22: pp S419, 1987.

113. Neff, N.H., Qu, Z-X., Moroi, S. and Hadjiconstantinou, M.: Retinal muscarinic receptorsand second messenger systems. Neurosci. Suppl. to Vol. 22, pp 5420, 1987.

114. Moroi, S.M., Neff, M.H. and Neff, N.H.: Acetylcholine stimulates phosphatidyinisitolturnover in rat retina. Soc. for Neurosci. Abstract, pp 1300, 360: 1987.

115. Rossetti, Z.L., Sotgin, A., Sharp, D., Hadjiconstantinou, M. and Neff, N.H.:Biotransformation of MPTP generates superoxide radicals in vivo. Soc. for Neurosci.Abstract, pp 71, 24: 1987.

116. Hadjiconstantinou, M. and Neff, N.H.: Administration of GM-1 ganglioside restoresdopamine content in the striatum of MPTP-treated mice. Soc. for Neurosci. AbstractVol. 13, pp 1607, 443.16: 1987.

117. Moroi, S., Qu, Z-X, Hadjiconstantinou, M. and Neff, N.H.: Protein kinase A and Cinteractions in the rat retina. Trans. of Amer. Soc. Neurochem. 19(1):165, 1988.

118. Varol, F.G., Hadjiconstantinou, M. Zuspan, F.P. and Neff, N.H.: Muscarinic receptormediated phosphoinositide hydrolysis in rat uterus. FASEB Jnl. 2(40):1839, 1988.

119. Hadjiconstantinou, M., Qu, Z-X., Moroi-Fetters, S.E., Le, G-Y. and Neff, N.H.: Apparentloss of Gi protein activity in diabetic retinopathy. Soc. for Neurosci. Abstracts. Vol. 14,pp 84, 36.17, 1988.

120. Wemlinger, T.A., Isaacs, L.A., Weiss, H.S., Neff, N.H., Yates, A.J. andHadjiconstantinou, M.: GM1 restores dopamine, and acetylcholine in the brain ofdeveloping rats after hypoxia. Soc. for Neurosci. Abstracts. Vol. 14, pp 1246, 500.4,1988.

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121. Moroi-Fetters, S.E., Qu, Z-X, Le, G-Y., Hadjiconstantinou, M. and Neff, N.H.: Muscarinicreceptors and second messenger systems in the rat retina. Soc. for Neurosci.Abstracts. Vol. 14, pp 989, 396.16, 1988.

122. Hadjiconstantinou, M., Mariani, A.P., Qu, Z-X and Neff, N.H.: Retinal dopamine

amacrines are sensit ive to MPTP neurotoxicity. MPTP - SARDINIA'88. Degenerationand Regeneration Processes in CNS. Ab. C-4, pp 46., 1988.

123. Neff, N.H., Hadjiconstantinou, M., Mariani, A.P., Weihmuller, F.B. and Bruno, J.P.:Reversal of neurotransmitter and behavioral deficits following MPTP by administeringGM1 ganglioside. MPTP-SARDINIA'88. Degeneration and Regneration Processes inCNS. Ab. D-4, pp 66., 1988.

124. Hadjiconstantinou, M., Weihmuller, F.B., Bruno, J.P. and Neff, N.H.: The MPTP-treatedmouse: behavioral sequela. American College of neuropsychopharmacology.Abstracts. pp 141, 1988.

125. Silvia, C.P., Hadjiconstantinou, M., Kolattakudy, P.E. and Neff, N.H.: Partial sequenceof aromatic L-amino acid decarboxylase. American Society for Neurochemistry. Ab.171, pp 171, 1989.

126. Hadjiconstantinou, M., Moroi-Fetters, S.E., Qu, Z-X, and Neff, N.H.: Pharmacologicalcharacterization of retinal muscarinic receptors. The Pharmacologist. Vol. 31, No. 3, pp141, Ab. 103, 136, 1989.

127. Hadjiconstantinou, M., Neff, N.H. and Yates, A.J.: GM1 restores the hypoxia-inducedchanges in dopamine and acetylcholine in the brain of developing rats. J. Neurochem.Vol. 52, Supplement, S187C, 1989.

128. Hadjiconstantinou, M., Weihmuller, F.B., Bruno, J.P., Mariani, A. and Neff, N.H.:

Recovery of dopaminergic function following MPTP-induced neurodegeneration byexogenous GM1 ganglioside. "Trophic factors and the nervous system" Abstracts,1989.

129. Weihmuller, F.B., Hadjiconstantinou, M., Bruno, J.P. and Neff, N.H.: Continued GM1ganglioside administration is required to maintain biochemical and behavioral recoveryin mice exposed to MPTP. Soc. for Neurosci. Abstracts, Vol. 15, p 40, 22.7, 1989.

130. Hadjiconstantinou, M. Sylvia, C.P., Hubble, J.P., Isaacs, L.A., Wemlinger, T.A. and Neff,N.H.: Modulation of striatal aromatic L-amino acid decarboxylase. Soc. for Neurosci.Abstracts, pp 1312, 517.19, 1989.

131. Hadjiconstantinou, M. Rossetti, Z.L., Silvia, C.P., Krajnc, D. and Neff, N.H.: Receptormediated modulation of aromatic L-amino acid decarboxylase activity of retinal andnigrostriatal dopaminergic neurons. Eur. J. Pharmacol. Vol. 183/2 Abs. 261, pp 427,1990.

132. Hadjiconstantinou, M. Rossetti, Z.L., Silvia, C.P., Krajnc, D. and Neff, N.H.: Aromatic L-amino acid decarboxylase activity of striatum and retina are modulated via dopaminergicreceptors. Dopamine 90. Satellite Meeting of the XI International Congress of

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Pharmacology. "Dopaminergic systems and their regulation". Abstract, 1990.

133. Gudehithlu K.P., Duchemin, A.M., Dalia, D.A., Neff, N.H. and Hadjiconstantinou, M.:Temporal changes in the expression of the glutamate transporter from rat cortical poly(A)+ RNA in Xenopus Oocytes. Soc. for Neurosci. Abs, pp 30, 19.11, 1990.

134. Krajnc, D., Gudehithlu, K.P., Duchemin, A-M., Hadjiconstantinou, M. and Neff, N.H.: c-Fos gene expression and glutamate content are increased while glutamine content isdecreased in the brain of developing rats after transient hypoxia. Soc. for Neurosci.Abs, pp 849, 352:12, 1990.

135. Neff, N.H., Stanisic, J., Krajnc, D. and Hadjiconstantinou, M.: GM1 ganglioside preventshypoxia-induced neurotransmitter changes in the brain of the developing rat. Soc. forNeurosci. Abs, pp 942, 386.16, 1990.

136. Hadjiconstantinou, M., Karadsheh, N.S., Tejwani, G.A. and Neff, N.H.: Treatment withGM1 ganglioside increases the transport of choline into synaptosomes prepared fromdiscrete brain regions of aged rats. First annual All-Ohio Alzheimer's DiseaseSymposium. Abs, pp 48, 1990.

137. Gudehithlu, K.P., Duchemin, A.M., Dalia, D.A., Neff, N.H. and Hadjiconstantinou, M.:Temporal changes in the expression of the glutamate transporter from rat cortical poly(A)+ mRNA in Xenopus oocytes. First Annual All-Ohio Alzheimer's Disease Symposium.Abs, pp 22, 1990.

138. Duchemin, A-M., Gudehithlu, K.P., Neff, N.H. and Hadjiconstantinou, M.: Acute MPTPinduces c-fos gene expression in mouse brain. Soc. for Neurosci. Abs. pp 1260,515.16, 1990.

139. Hadjiconstantinou, M., Qu, Z-X and Neff, N.H.: Some dopamine D2 receptors may notbe coupled to adenylate cyclase in the rat retina. Soc. for Neurosci. Abs. pp 567,237.20, 1990.

140. Hadjiconstantinou, M., Duchemin, A-M, Gudehithlu, K.P., Silvia, C.P. and Neff, N.H.:Characterization of an aromatic L-am ino acid decarboxylase clone in Xenopus Laevisoocytes. ACNP, Abs, pp 98, 1990.

141. Hadjiconstantinou, M., Karadsheh, A.K. Rattan, A.K. Tejwani, G.A. and Neff, N.H.:Treatment with GM1 ganglioside improves cholinergic parameters in the brain of agedrats. Symposium on: Gangliosides: The Pharmacology of Neuronal Plasticity. Abs, ppP27, 1991.

142. Krajnc, D., Neff, N.H. and Hadjiconstantinou, M.: GM1 ganglioside prevents short-termneurotransmitter changes in the brain of developing rats exposed to hypoxia.Symposium on: Gangliosides: The Pharmacology of Neuronal Plasticity. Abs, pp P44,1991.

143. Hadjiconstantinou, M. and Neff, N.H.: GM1 ganglioside and MPTP-inducedparkinsonism. Symposium on: Gangliosides: The Pharmacology of Neuronal Plasticity.Abs, pp S10, 1991.

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144. Neff, N.H., Duchemin, A-M., Gudehithlu, K.P., Silvia, C.P. and Neff, N.H.: Expressionof an aromatic L-amino acid decarboxylase clone in Xenopus oocytes. ASN, Abs 48,pp 108, 1991.

145. Hadjiconstantinou, M., Karadshesh, N.S., Rattan, A.K., Tejwani G.A. and Neff, N.H.:Treatment with GM1 enhances cholinergic indices in the brain of aged rats. ASN, Abs48, pp 108, 1991.

146. Hadjiconstantinou, M., Karadshesh, N.S., Rattan, A.K., Tejwani, G.A. and Neff, N.H.:GM1 ganglioside treatment improves cholinergic parameters in the brain of senescentrats. IBRO, Abs P13.2, pp 102, 1991.

147. Quach, T.T., Duchemin, A-M., Gudehithlu, K.P., Hadjiconstantinou, M. and Neff, N.H.:Expression and activity of structurally modified aromatic L-amino acid decarboxylasegene in Xenopus Laevis oocytes. IBRO, Abs P17.10, pp 120, 1991.

148. Neff, N.H., Duchemin, A-M., Gudehithlu, K.P., Silvia, C.P. and Hadjiconstantinou, M.:Characterization of an aromatic L-amino acid decarboxylase clone expressed inXenopus Laevis oocytes. IBRO, Abs P41.35, pp 279, 1991.

149. Duchemin, A-M., Gudehithlu, K.P., Neff, N.H. and Hadjiconstantinou, M.: Induction ofimmediate-early genes expression in mouse brain be acute MPTP treatment. IBRO,Abs P51.21, pp 335, 1991.

150. Krajnc, D., Duchemin, A-M., Neff, N.H. and Hadjiconstantinou, M.: Modulation ofimmediate-early gene expression by GM1 ganglioside. Soc. Neurosci., Abs Vol 17

301.24, pp 755, 1991.

151. Dalia, A., Neff, N.H. and Hadjiconstantinou, M.: GM1 ganglioside corrects the loss ofDA uptake activity in embryonic mesencephalic cultures treated with MPP+. Soc. forNeurosci. Abs Vol 17 301.25, pp 755, 1991.

152. Hadjiconstantinou, M., Eaton, M., Fitkin, J.G. and Neff, N.H.: NGF facilitates therecovery of nigrostriatal dopaminergic neurons after a lesion induced by MPTP. Soc.Neurosci. Abs Vol 17 599.5, pp 1496, 1991.

153. Gudehithlu, K.P., Tejwani, G.A., Neff, N.H. and Hadjiconstantinou, M.: Nicotine altersPPE mRNA and met-enkephal in of s triatum. American Society for Neurochemistry, Abs257, pp 218, 1992.

154. Eaton, M.J., Silvia, C.P., Quach, T.T., Gudehithlu, K.P., Duchemin, A-M., Neff, N.H. andHadjiconstantinou, M.: Brain aromatic L-amino acid decarboxylase: an in situhybridization study. American Society for Neurochemistry, Abs 269, pp 224, 1992.

155. Dalia, A., Neff, N.H. and Hadjiconstantinou, M.: NGF corrects the loss of DA uptake

activity in embryonic mesencephalic cultures treated with MPP+. Soc. for Neurosci., Abs266.9, pp 614, 1992.

156. Neff, N.H., Wemlinger, T.A. and Hadjiconstantinou, M.: DFP enhances the neurotoxicityof MPTP. Soc. for Neurosci., Abs 282.7, pp 664, 1992.

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157. Hadjiconstantinou, M., Wemlinger, T.A., Hubble, J.P., Silvia, C.P. and Neff, N.H.:Modulation of dopa decarboxylase in the striatum of a mouse model of Park inson'sDisease. Soc. for Neurosci., Abs 282.6, pp 664, 1992.

158. Eaton, M.J., Gudehithlu, K.P., Silvia, C.P., Hadjiconstantinou, M. and Neff, N.H.:

Distribution of aromatic L-amino acid decarboxylase mRNA in mouse brain. Soc. forNeurosci., Abs 408.20, pp 969, 1992.

159. Gudehithlu, K.P., Duchemin, A.M., Neff, N.H. and Hadjiconstantinou, M.: Light-inducedexpression of immediate early genes in rat retina. Soc. for Neurosci., Abs 557.7, pp1318, 1992.

160. Hadjiconstantinou, M., Eaton, M.J., Fong, T.G. and Neff, N.H.: NGF and dopaminergic

neurons I recovery of nigrostriatal neurons in vivo after a lesion induced by MPTP.Transaction of the Am. Soc. for Neurochem. 24: p 111, 1993.

161. Neff, N.H., Dalia, A. and Hadjiconstantinou, M.: NGF and dopaminergic neurons IIrecovery in mesencephalic cultures after a lesion induced by MPP+. Transaction of theAm. Soc. for Neurochem . 24: p 112, 1993.

162. Rossetti, Z.L., Wemlinger, T.A., Neff, N.H. and Hadjiconstantinou, M.: Ethanolwithdrawal is associated with a decrease in brain dopa-decarboxylase activity.European Society for Biochemical Research on Alcoholism, Abstracts, 1993.

163. Neff, N.H. and Hadjiconstantinou, M.: Modulation of retinal aromatic L-am ino aciddecarboxylase by light and neuroactive drugs. Symposium on Ocular Pharmacology,Abstracts, pp. 17, 1993.

164. Young, E.A., Neff, N.H. and Hadjiconstantinou, M.: Aromatic L-am ino aciddecarboxylase: I Evidence for enzyme modulation in brain by cyclic-AMP mediatedevent. Soc. for Neurosci. Abstracts, Vol. 19, pp. 738, 1303.16, 1993.

165. Hadjiconstantinou, M., Young, E.A. and Neff, N.H.: Aromatic L-amino ac iddecarboxylase: II Evidence for enzyme modulation in brain by a protein kinase Cmediated event. Soc. for Neurosci. Abstracts, Vol. 19, pp. 738, 303.17, 1993.

166. Neff, N.H. and Hadjiconstantinou, M.: GM1 ganglioside and Parkinsonism: In vivo andin vitro studies. Gangliosides and Neural Repair. Satellite Symposium at 24th AnnualMeeting of ASN, Abstracts, pp. 11, 1993.

167. Hadjiconstantinou, M., Young, E.A. and Neff, N.H.: Nigrostriatal aromatic L-amino ac iddecarboxylase (AAAD) activity is increased transiently after treatment with phorbol ester.American College of Neuropyschopharmacology. Abstracts #129, pp. 219, 1993.

168. Hadjiconstantinou, M. and Neff, N.H.: MPTP may be more neurotoxic to dopaminergicneurons that are activated. American College of Neuropsychopharmacology. Abstracts,pp. 129, 1993.

169. Copeland, B.J., Vogelsberg, V., Neff, N.H. and Hadjiconstantinou, M.: Phorbol estersdecrease dopamine uptake into striatal synaptosomes. Transactions of the American

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Society for Neurochemistry. 25:285, 378, 1994.

170. Vogelsberg, V., Copeland, B.J., Neff, N.H. and Hadjiconstantinou, M.: Modulation of thehigh-affinity choline transporter. Transaction of the American Society forNeurochemistry. 25:297, 403, 1994.

171. Hadjiconstantinou, M., Fong, T.G. and Neff, N.H.: Chronic administration of GM1ganglioside enhances cholinergic parameters in the aged brain. Soc. for Neurosci.Abstracts Vol. 20, pp. 1708, 697.1, 1994.

172. Neff, N.H., Dhatt, R.K., Wemlinger, T.A., Tejwani, G.A. and Hadjiconstantinou, M.:Nicotine increases met-enkephalin content and preproenkephalin mRNA in mousestriatum. Soc. for Neurosci. Abstracts Vol. 20, pp. 1235, 503.22, 1994.

173. Hadjiconstantinou, M., Fong, T.G., Vogelsberg, V. and Neff, N.H.: GM1 gangliosideenhances cholinergic markers and potentiates the response to NGF in the brain of agedanimals. J. Neurochem . 64 (Suppl):S9C, 1995.

174. Hadjiconstantinou, M.: GM1 and recovery of dopaminergic function in the MPTP-treatedmouse model of parkinsonism. J. Neurochem. 64 (Suppl)S43A, 1995.

175. Young, E.A., Neff, N.H. and Hadjiconstantinou, M.: Second messenger mediated effectson L-aromatic amino acid decarboxylase and tyrosine hydroxylase in normal and MPTP-lesioned mouse striatum. J. Neurochem. 64 (Suppl):S53C, 1995.

176. Cho, S., Hadjiconstantinou, M. and Neff, N.H.: The modulation of aromatic L-amino aciddecarboxylase (AAAD) by long-term treatment with dopaminergic drugs. The FASEBJournal. Abstracts. pp A372, 2154, 1995.

177. Fong, T.G., Neff, N.H. and Hadjiconstantinou, M.: Aged animals show improvem ent ina Morris Water Maze test following administration of GM1 ganglioside. Soc. forNeurosci. Abstracts Vol.21, pp. 196, 82.4, 1995.

178. Isola, R., Vogelsberg, V., Wemlinger, T.A., Neff, N.H. and Hadjiconstantinou, M.:Nicotine withdrawal in the mouse. Soc. for Neurosci. Abstracts Vol. 21, pp. 6722, 289.1,1995.

179. Neff, N.H., Hadjiconstantinou, M., Wemlinger, T.A., and Rossetti, Z.L.: Tyrosinehydroxylase and aromatic L-amino acid decarboxylase activities during ethanolwithdrawal. Soc. for Neurosci. Abstracts Vol. 21, pp. 1134, 446.88, 1995.

180. Cho, S., Hadjiconstantinou, M. and Neff, N.H.: Modulation of tyrosine hydroxylase andaromatic L-amino acid decarboxylase in mouse striatum after inhibition of monoamineoxidase. Soc. for Neurosci. Abstracts Vol. 21, pp. 1135, 446.9, 1995.

181. Berry, M.D., Hadjiconstantinou, M. and Neff, N.H.: Aromatic L-amino acid decarboxylaseactivity is regulated by phosphorylation. Soc. for Neurosci. Abstracts Vol. 21, pp. 1135,446.10, 1995.

182. Young, E.A., Neff, N.H. and Hadjiconstantinou, M.: Second messenger modulation of

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L-aromatic amino acid decarboxylase and tyrosine hydroxylase in normal and MPTP-lesioned mouse striatum. Soc. for Neurosci. Abstracts Vol. 21, pp. 1258, 491.11, 1995.

183. Copeland, B.J., Neff, N.H. and Hadjiconstantinou, M.: Protein kinase C activatorsdecrease dopamine uptake into srtiatal synaptosomes. Soc. for Neurosci. AbstractsVol. 21, pp. 1381, 543.10, 1995.

184. Vogelsberg, V., Neff, N.H., Hadjiconstantinou, M.: The high-affinity choline transporteris modulated in vivo by db-cAMP. Soc. for Neurosci. Abstracts Vol. 21, pp. 2064,811.18, 1995.

185. Fong, T.G., Neff, N.H. and Hadjiconstantinou, M.: GM1 increases the cross-sectionalarea of ChAT-immunopositive neurons in the aged brain. J. Neurochem. Abstracts Vol.66 (Suppl 1) S11A, 1996.

186. Vogelsberg, V., Fong, T.G., Neff, N.H. and Hadjiconstantinou, M.: Neurochemicalcholinergic deficits in aged spinal cord: restoration by GM1 ganglioside. J. Neurochem.Abstracts Vol. 66 (Suppl 1) S11B, 1996.

187. Hadjiconstantinou, M. and Neff, N.H.: Modulation of neuronal aromatic L-amino aciddecarboxylase. J. Neurochem. Abstracts Vol 66 (Suppl 1) S78A, 1996.

188. Hadjiconstantinou, M., Isola, R., Wemlinger, T.A., Tejwani, G.A. and Neff, N.H.: Nicotinealters met-enkephalin content and preproenkephalin mRNA in the striatum of mice.Soc. for Neurosci. Abstracts Vol. 22, pp. 164, 70.5, 1996.

189. Fong, T.G., Neff, N.H. and Hadjiconstantinou, M.: Morphologic changes of ChAT- orp75-immunopositive neurons in the aged rat following treatment with GM1 ganglioside.Soc. for Neurosci. Abstracts Vol. 22, pp. 742, 299.9, 1996.

190. Neff, N.H., Cho, S., Weiss, B. and Hadjiconstantinou, M.: Dopamine receptors and theregulation of tyrosine hydroxylase and aromatic L-amino acid decarboxylase. Soc. forNeurosci. Abstracts Vol. 22, pp. 1316, 522.10, 1996.

191. Copeland, B.J., Neff, N.H. and Hadjiconstantinou, M.: Stress increases dopamineuptake in the striatum of mice. Soc. for Neurosci. Abstracts Vol. 22, pp. 1577, 620.11,1996.

192. Higgins, D.S., Butchbach, M.E.R., Fong, T.G., Neff, N.H. and Neff, M.H: GM1ganglioside modulation of the electron transport chain in aged rats. Soc. For Neurosci.Abstracts Vol. 23, pp. 894, 355.16, 1997.

193. Duchemin, A.M., Neff, N.H. and Hadjiconstantinou, M.: GM1 ganglioside induces Trkphosphorylation in rat brain. Soc. for Neurosci. Abstracts Vol. 23, pp. 1435, 566.14,1997.

194. Goettl, V., Wemlinger, T.A., Duchemin, A.M., Neff, N.H. and Hadjiconstantinou, M.: GM1restores dopaminergic indices in the aged brain. Soc. for Neurosci. Abstracts Vol. 23,pp. 2036, 793.2, 1997.

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195. Duchemin, A.-M., Neff, N.H. and Hadjiconstantinou, M.: GM1 increases the content andRNA of NGF in the brain of aged rats. J. Neurochem. Abst. 70, Suppl 1. S25B, 1998.

196. Ren, Q., Duchemin, A.-M., Neff, N.H. and Hadjiconstantinou, M.: GM1 increases theactivity of MAP kinase in brain slices. J. Neurochem. Abst. 70, Suppl 1, S14B, 1998.

197. Hadjiconstantinou, M., Isola, R., Wemlinger, T.A., Tejwani, G., Neff, N.H. and Duchemin,A.-M.: Nicotine alters endogenous opioid peptides in the mouse brain. Naunyn-Schmiedeberg’s Archives of Pharmacology. 358, Suppl 1, P5.33, R. 92, 1998.

198. Hadjiconstantinou, M., Copeland, B.J. and Neff, N.H.: Modulation of dopaminetransporter by repeated restraint stress. Naunyn-Schmiedeberg’s Archives ofPharmacology. 358, Suppl 1, P7.15, R. 98, 1998.

199. Neff, N.H., Duchemin, A.-M., Young, E.A. and Hadjiconstantinou, M.: Parallel regulationof tyrosine hydroxylase and aromatic L-amino acid decarboxylase in the striatum by PKCand PKA. Naunyn-Schmiedeberg’s Archives of Pharmacology. 358, Supp 1, P7.20, R99, 1998.

200. Duchemin, A.-M., Ren, Q., Neff, N.H. and Hadjiconstantinou, M.: GM1-inducedphosphorylation of TRK and activation of ERKs in brain slices. Naunyn-Schmiedeberg’sArchives of Pharmacology. 358, Supp 2, P23.10, R 666, 1998.

201. Ren, Q., Duchemin, A.-M., Neff, N.H. and Hadjiconstantinou, M.: GM1 activates Erk1and Erk2 in slices prepared from rat striatum. Soc. for Neurosci. Abstracts, Vol 24:1295,514.16, 1998.

202. Hadjiconstantinou, M., Duchemin, A.-M., Wemlinger, T.A. and Neff, N.H.: Erks activatetyrosine hydroxylase in nigrostriatal dopaminergic neurons. Soc. for Neurosci.Abstracts, Vol 24:1116, 441.1, 1998.

203. Duchemin A..-M., Varol, F.G., Neff, N.H. and Hadjiconstantinou, M.: Down regulation ofNGF content and mRNA in rat uterus during pregnancy. Soc. for Neurosci. Abstracts,Vol 24:293, 18.20, 1998.

204. Isola, R., Duchemin, A.-M., Tejwani, G.A., Neff, N.H. and Hadjiconstantinou, M.: Roleof dopamine and glutamate receptors in the nicotine-induced chain of met-enkephalin.Soc. for Neurosci. Abstracts, Vol 25:1067, 436.4, 1999.

205. Neff, N.H., Wemlinger, T.A. and Hadjiconstantinou, M.: Enhanced conversion ofexogenous L-DOPA to dopamine in striatum and midbrain: a potential new approach totreat Parkinson’s disease. Soc. for Neurosci. Abstracts Vol 25:332, 132.19, 1999.

206. Goettl, V.M., Lindsey, A.E., Neff, N.H. and Hadjiconstantinou, M.: Mechanical andnoxious thermal stimuli in aged rats and the effect of GM1 ganglioside. Soc. forNeurosci. Abstracts Vol 25:33,21,10, 1999.

207. Ren, Q., Neff, N.H. and Hadjiconstantinou, M.: GM1 ganglioside activates PI-3 kinasein the brain. Soc. for Neurosci. Abstracts Vol 25P508, 198.1, 1999.

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208. Duchemin, A.-M., Quach, T.T., Hadjiconstantinou, M. and Neff, N.H.: Molecularcharacterization of mouse aromatic L-amino acid decarboxylase: cDNA, neuronalpromoter, and gene structure. Soc. for Neurosci. Abstracts Vol 25:1213, 487.15, 1999.

209. Neff, N.H., Azad A., Wemlinger T.A., Duchemin A.M., Quach T.T. andHadjiconstantinou M.: Aromatic L-amino acid decarboxylase: mutational analysis. J.Neurochem,. Vol. 74 Supplement S37, C, 2000.

210. Hadjiconstantinou M., Ren Q., Duchemin A-M. and Neff, N.H. : Activation of brain Pl-3kinase by GM1 ganglioside. J. Neurochem. Vol 74, Supplement S22, A, 2000.

211. Neff, N.H., Azad, A., Wemlinger, T.A., Duchemin, A.M., Quach, T.T., andHadjiconstantinou, M.: Mutational analyses of aromatic L-amino acid decarboxylase.Soc. for Neurosci. Abstracts Vol 26:436.12, 2000.

212. Goettl, V.M., Wemlinger, T.A., Colvin, A.E., Neff, N.H. and Hadjiconstantinou, M.: GM1treatment effects on motor activity and striatal D1 and D2 receptors in aged rats. Soc.for Neurosci. Abstracts Vol 26:873.8, 2000.

213. Hadjiconstantinou, M., Goettl, V.M. and Neff, N.H.: GM1 and motor neurons. Soc. forNeurosci. Abstracts Vol 26:257.4, 2000.

214. Podell, Neff, N. and Hadjiconstantinou, M.: Magnetic resonance imaging andspectroscopsy identifies structural and biochemical changes after MPTP-inducedParkinson’s Disease in cats. Soc. for Neurosci. Abstracts Vol 26:279, 12, 2000.

215. Duchemin, A.M., Neff, N.H. and Hadjiconstantinou, M.: Cyclic amp-dependent proteinkinase phosporylates and activates native and recombinant aromatic L-am ino aciddecarboxylase. Soc. for Neurosci. Abstracts Vol 26:436.22, 2000.

216. McCarthy, M. Duchemin, A.M., Wemlinger, T.A. Neff, N.H. and Hadjicaonstantinou, M.Acute nicotine enhances the expression of opioid peptide precursors ans immediateearly genes, Soc. Neurosci. Abst. Vol 27 Program # 222.12, 2001.

217. Hadjiconstantionou, M., Isola, R., Colvin, A., Tejwani, G., Neff, N.H. and Duchemin,A.M., Dynorphin changes in the striatum of mice after acute nicotine or nicotinewithdrawal. Soc. Neurosci. Abst. Vol 27, Program # 222.13, 2001.

218. Duchemin, A.M., Hadjiconstantionou, M. and Neff, N.H., Cyclic GMP-dependent proteinkinase phosphorylates and activates brain aromatic L-amino acid decarboxylase. Soc.Neurosci. Abst. Vol 27, Program # 260.1, 2001.

219. Mo,L., Duchemin, A.M., Ren, Q., Neff, N.H. and Hadjiconstantinou, M. GM1 signalingtransduction in the brain of young and aged rats. Soc. Neurosci. Abst. Vol 27, Program# 861.10, 2001.

220. Mo,L., Neff, N.H., and Hadjiconstantinou, M., Regulation of JNK Signaling Pathway byGM1 Am Soc Neurochem Abstract 10031, 2002.

221. Neff, N.H., Duchemin, A.-M., and Hadjiconstantinou, M. Activation of aromatic

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L-amino acid decarboxylase by calcium/calmodulin kinase II. Am Soc. Neurochem.,Abstract 10051, 2002.

222. Hadjiconstantinou, M., Isola, R., Colvin, A., Tejwani, G., Neff, N.H. and Duchemin, A.-M.Altered Dynorphin in the Striatum after Acute Nicotine or Nicotine W ithdrawal. Am Soc.Neurochem. Abstract 10033, 2002.

223. Mo, L., Neff,N.H. and Hadjiconstantinou, M. GM1 Regulation of the Jnk SignalingPathwayand Transcription Factor Targets in Aged and Young Rats. Soc. Neurosci.Abst., Program # 790.4 2002.

224. Hadjiconstantinou, M.H., Goettl, V.M., Zhang,H. Colvin, A., Wemlinger, T.A. and Neff,N.H. GM1 Restores Dopaminergic Presynaptic Markers in the Striatum of Aged Rats.Soc. Neurosci. Abst. Program # 790.8. 2002.

225. Duchemin, A.M., Neff, N.H. and Hadjiconstantinou,M.H. Calcium/calmodulin-dependentProtein Kinase II Activates Aromatic L-amino Acid Decarboxylase in StriatumHomogenates. Soc. Neurosci. Program # 887.14 2002.

226. Neff, N.H., Podell, M. And Hadjiconstantinou, M. Feline Park inson Disease Model: MRIand MRS Identifies Structural and Biochemica l Changes After MPTP. American Societyfor Neurochemistry, 2003 No. 10023.

227. Hadjiconstantinou, M. Duchemin, A.M. and Neff, N.H. Cyclic GMP-Dependent ProteinKinase Phsophorylates and Activates Brain Aromatic L-Amino Acid Decarboxylase.American Society for Neurochemistry, 2003 No. 10024.