Nikken Ciaga V Highest Antioxidant

Superfruits

Cardiovascular, Immune, Antioxidant, Gastrointestinal,

and Anti-aging

What’s in Ciaga V?• 5 Highest Antioxidant Superfruits: Maqui Berry,

Elderberry, Acai Berry, Blackberry, Raspberry • Certified Organic US NOP and EU

• 100% from pollution free native forest (Far from industrial, main roads, polluted water & air source)

• 100% pesticides and herbicides free

• Maqui Berry is wild harvested by the Mapuche Indians, utilizing sustainable harvesting practices

What’s Maqui Berry?

• Deeply purpled berry from Patagonia region• Harsh climate, sun irradiation, environment

and biological enemies• Highest Antioxidant value as measured by

ORAC• Broadest Antioxidant protection as measured

by Total ORAC • High concentration of anthocyanins

(especially the delpinidin) and polyphenols

Traditional Use

A sacred plant used in many ceremonial practices such as harvest, birth, marriage, death, and war.

Traditionally used by the Mapuche Indians for:

• increasing strength and stamina, • Creating body warmth during Winter• Boost Immune Health• Treat diabetes, cancer, fever, ulcer, child

delivery

Benefits of Maqui Berry• Very High level of Polyphenols • Highest Anthocyanins, especially delphinidin • Supports Healthy Aging • Protects Cells from Oxidative Stress • Neutralizes Free Radicals • Supports Healthy Immune & Inflammatory

Function • Natural COX-2 Inhibitor • Supports Cardiovascular Health • Inhibits LDL Oxidation• Reduction of Insulin resistance• Possible weight loss benefits: Thermogenic

Highest ORAC Compared to Any Fruit on the Planet

* Data obtained from USDA ORAC report Nov 2007† Data value obtained from Independent Lab report from Brunswick Laboratories, MA

Fruits H-ORAC µmole TE/g

Maqui, Frozen Fruit 276 †

Acai, Frozen Fruit 167 †

Elderberry, Fruit 145 *

Pomegranate, Fruit 105 †

Blueberry, Fruit 65 *

Blackberry, Fruit 52 *

ORAC hydro Comparison of Juices

* Data value obtained from Independent Lab report from Brunswick Laboratories, MA

† Data obtained from J Agric. Food Chem.,Vol 56, No 4, 2008

Juice/Liquid H-ORAC µmole TE/ozMaqui berry, Juice 3300 to 6000 *

Ciaga V 1671 †

Red Wine 771 †

Black Cherry, Juice 759 †

Pomegranate, Juice 750 †

Blueberry, Juice 618 †

Acai, Juice 585 †

Cranberry, Juice 462 †

Orange, Juice 222 †

Anthocyanins & Total Phenols (Fruits)

 

Anthocyanins (mg/100g)

Total Phenols (mg/100g)

Maqui Berry, Fruit 1132 -2748 2182-2419

Red Grape, Fruit 30-750

Boysenberry, Fruit 160

Cherry, Fruit 350-400 1500

Blackberry, Fruit 82-325 3000

Cranberry, Fruit 50-80 1000

Red Raspberry, Fruit 213-428 1300

Black Raspberry, Fruit 400 1300

Blueberry, Fruit 25-495

Bilberry, Fruit 300-648 400

Total Phenols in Juice

 

Total Phenols (mg/30ml)

Maqui Berry, 17 brix Juice 338-584

Pomegranate Juice 114

Red Wine 105

Concord Grape Juice 78

Blueberry Juice 69

Acai Juice 63

Black Cherry Juice 63

Cranberry Juice 51• Provide plants with color• 4,000 known polyphenols

Total ORAC Test

• Original ORAC method only test against 1 free radicals---peroxyl. 

• "Total ORAC test" measure 5 different radicals that are commonly found in human.

- Hydroxyl- Peroxyl- Peroxynitrite - Singlet oxygen - Superoxide anion

Total ORAC per oz

 

ORAC-H ORAC-L (Peroxyl)

HORAC (Hydroxyl)

NORAC (Peroxynitrite)

SORAC (Super Anions)

SOAC (Singlet oxygen Hydroxyl)

Total ORAC

Maqui Berry, 17 brix Juice

3926.00

15,310.00 548.00

9556.00

3683.00 33,023

Ciaga V1671.60

6222.00 140.40

4152.60

4223.10

16,409.7

Grape, Juice 519.59 73.70 45.30 866.68 437.501941.50

Coffee, Brewed 486.12 92.35 47.97 540.93 689.07

1856.43

V8 vegetable Juice 166.11 39.28 20.25 306.58

1224.96

1757.16

Green Tea, Brewed 282.88 44.43 54.90

1045.89 0

1428.09

Maqui Berry Inhibit LDL Oxidation and Protect Cells against Oxidative Stress

• Oxidized LDL cause atherosclerosis - induces oxidative stress - develop fatty streak lesion in arterial wall• Fruit phenols protect cells from oxidative

stress induced by different stressors• Maqui Berry: very high in phenols &

antioxidant - Protects LDL from oxidation - Protects cells from oxidative stress

TRAP & TAR TRAP: measure amount of free

radicals that can be trapped

TAR: capacity to decrease the steady-state free radical concentration

Higher Phenols =

higher TRAP & TAR

(result based on single strength fruit brix)

Anti-inflammatory Action

NFkB • Key regulator of our immune and inflammatory response system

• Controls pro-inflammatory cytokines that causes inflammation & pain

Maqui berry inhibits NFkB --- turns off switch to inflammation --- reduce cytokines and enzymes that causes inflammation Evaluation and development of botanical drugs from Aristotelia Chilensis, 2008

Maqui Berry Activates PPAR gamma

PPAR gamma Activation of PPAR

gamma inhibition of NFkappaB reduction of COX-2 enzyme & prostaglandin level reduction in inflammation & pain

Maqui berry activates PPAR gamma ---inhibits NF kappa B --- reduce COX-2 ---anti-inflammatoryEvaluation and development of botanical drugs from Aristotelia Chilensis, 2008

Natural COX-2 Inhibitor• COX-2: responsible for inflammation and pain • Triggered by inflammatory cytokines and NFkappaB.• Cancer, Arthritis • 100mg/kg of Maqui significantly reduced COX-2 between 0 to 6

hours, effect similar to 2mg/kg of diclofenac (COX-2 inhibior drug)• Maqui berry inhibit NFkappaB --- Reduce COX-2 --- Natural COX-2

Inhibitor Evaluation and development of botanical drugs from Aristotelia Chilensis, 2008

Completely erase COX-2 at 24 hours

Effects of Maqui on Caco-2 Cancer Cell

Completely eliminate Caco-2 cell at 4 hours, 8 hours, and 16 hours

Evaluation and development of botanical drugs from Aristotelia Chilensis, 2008

BergisterolsCholesterol, Blood Glucose,

Weight Loss

• Citrus Bergamia Risso• Origin: Calabria, Italy• 95% worldwide production

Health Benefits of Bergisterol

• Cardiovascular Health• Reduce Total Cholesterol• Reduce LDL, inhibit LDL oxidation• Reduce Triglycerides• Increase HDL : inhibits plague formation• Reduce Blood Sugar Level (diabetic)• Improve Vasodilatation• Maintain Blood Pressure• Significant Reduction of Coronary Artery Disease risk • Weight Loss

Statin Like Compounds in Bergamonte

J Nat Prod. 2009 Jul;72(7):1352-4

• 3-hydroxy-3-methylglutaric acid (HMG) bound to neohesperidin (Brutieridin) and naringin (Melitidin)

• Inhibits HMG reductase: key intermediate in cholesterol metabolism

BrutelidinMelitidin

Bergamonte Reduces Total Cholesterol, LDL, Triglycerides, and Blood Glucose in Wistar Rats

Bergamonte Extract(20mg/kg/day)

-38+3% +26 +4% -35+5% -15+5% -16+4%

Pastazzo(5ml+5ml/kg/day)

-44+4% +36 +3% -40+5% -32+% -20+3%

Total cholesterol

HDL Cholesterol

LDL cholesterol

Triglycerides Blood glucose

Bergamot juice(20ml/kg/day)

-42+4% +31 +3% -44+5% -25+% -10+3%

Bergamonte Extract(20mg/kg/day)

-31+4% +26 +3% -28+5% -46+5% -40+3%

Bergamonte Reduces Total Cholesterol, LDL, Triglycerides, and Blood Glucose in Zuker Rats

3 dayscontrol

3 days afterballoon injury

3 days afterballoon injury

+Bergamot

Balloon injury --- scar tissue formation, increased LOX-1, increase free radical

Bergamot restores the antioxidant status ---- reduces free radical formation ---- reduces LOX-1 --- reduces injury arterial vessels

Citrus Bergamia Protects Arteries from Injury

  Total Chol LDL Chol HDL Chol Triglycerides

Optimal   <100 >60  

Normal <200 100-129 40-50 (men)50-60 (Women)

<150

Low     <40 (men)<50 (Women)

 

BorderlineHigh Risk

200-239 130-159   150-199

High Risk >240 160-189   200-499

Very High Risk

  >190   >500

Optimal Cholesterol Level

Bergamot Juice Reduces Blood Levels of Triglycerides, Cholesterol and Blucose in 192

Metabolic Syndrome Patients after 30 days

Total cholesterol

HDL Cholesterol

LDL cholesterol

Triglycerides Blood glucose

Bergamot juice (100 ml/Day)

-35.72% +56.05% -41.95% -38.31% -22%

- High Risk Total Cholesterol (>240)

- Low HDL-C (<40)

- LDL-C: Borderline (130-159), High Risk (160-189), to Very High Risk (>190)

-- High Risk Triglycerides (>200)

Hypolipemic and Hypoglycemic Activity of Bergamot Polyphenols

Fitoterapia 82 (Nov 2011) 309–316

Data is polled from 238 patients:(1) 82 patients with isolated hypercholesterolemia (LDL>130)(2) 76 patients with mixed dyslipedemia (hypercholesterolemia and hypertryglyceridemia)(3) 48 patients with mixed hyperlipemia and glycemia)(4) 32 patients previously on statin, 60 days wash out period

  Total-Chol

HDL-C

LDL-C Triglycerides

Blood glucose

Placebo 0.14% +1.2% -1.1% +0.1% +0.5%

Bergamonte (500mg/Day)

-20.69%

+22.9%

-24.1%

-29.9% -18.8%

Bergamonte (1000mg/Day)

-26.53%

+40.1%

-36.00%

-38.8% -22.3%

Statin Group (1500mg/day)

-24.61%

-27.6%

Bergamonte vs Statins

• Study design

• Patients : 77 (38 male 39 womans)

• Age: 61 + 6

• Inclusion criteria: LDLChol > 160 mg/dl + Triglycerides > 225 mg/dl

• Prospective, open-label, parallel group, controlled study

• Group 1 CTRL• Group 2 rosuvastatin 10 mg/day• Group 3 rosuvastatin 20 mg /day• Group 4 Bergamonte 1000 mg/day• Group 5 rosuvastatin 10 mg/day + Bergamonte 1000 mg/day

Bergamonte vs Statins

Common Side Effects of Statins

• Muscle Pain and Damage

• Liver Damage

• Digestive Problems

• Rash or Flushing

• Neurological Side Effects

• None with Bergamot

Product Comparison

Total Chol

LDL Triglycerides

HDL Blood Glucose

Bergamot 12%-48%

20%-59%

30%-55% 7%-83%

15%-30%

Statin 15%-50%

18%-55%

7%-12% 5-15% unknown

Sytrinol 20%-30%

19%-27%

24-34% 0% 0%

Citrus PMF 12%-18%

12%-16%

0% 0% 0%

Red Yeast Rice 15% 21% 0% 0% 0%

Phytosterols 15% 9% 0% 0% 0%