NEXGEN Four All automated microplate processors today can perform

the steps required to process an ELISA microplate test However, most systems today operate specifically

to their reagent menu and lack the capability to perform as a true open system We allow you to choose your reagent systems

Competitive systems claim 4-plate capability However, NO other system today can truly fulfill the

claim of utilizing all 4 plates simultaneously, providing you faster turnaround of results

NEXGEN Four Gives You

Effective laboratory integration

High volume throughput of results

Reliability

User choice of operation

Simple user interface

Comprehensive data reduction

Future laboratory requirements

NEXGEN Four

Effective Laboratory Operation Integration

Prevent costly sample pour-off

Various tube sizes / types within same rack

NEXGEN FourEffective Laboratory Operation Integration

Prevent costly sample pour-off Various tube sizes / types within same rack

Reduce barcode read failures Accommodate various barcode systems High percentage read rate Positive internal ID and external scanners

Easy interface format ASTM Bi-directional

Fully open reagent platform Accommodate existing manufacturers tests Eliminate lengthy correlations

NEXGEN Four

High Volume Throughput of Single or Multiple Tests Independent dual robotic arms

Simultaneous pipetting of multiple plates

NEXGEN Four

High Volume Throughput of Single or Multiple Tests Independent dual robotic arms

Simultaneous pipetting of multiple plates

Independent dual washheads Without utilizing robotic arm No plate transport systems

Simultaneous pipetting and washing

NEXGEN Four

High Volume Throughput of Single or Multiple Tests Continuous loading of samples

Easy to load individual sample sectors No waiting until existing run is complete Ability to add tests as runs finish

NEXGEN Four

High Volume Throughput of Single or Multiple Tests Continuous loading of samples

Easy to load individual sample sectors No waiting until existing run is complete Ability to add tests as runs finish

Minimized timing conflicts of processing steps Run more assays at one time Process more samples of the same assay

NEXGEN Four

High Volume Throughput of Single or Multiple Tests Ability to run infectious and non-infectious tests

simultaneously Ability to pipette both metal needle and plastic tips at the

same time

NEXGEN Four

High Volume Throughput of Single or Multiple Tests Ability to run infectious and non-infectious tests

simultaneously Ability to pipette both metal needle and plastic tips at the

same time

Intelligent sample / assay scheduling Automatic mode for sampling optimization Operator defined mode

NEXGEN Four

Reliability Proven design features supported by 15 years

experience Only four moveable components

Pipetting arm Plate carrier Washhead Carousel

Minimal linear plate movement

NEXGEN Four

Reliability Proven design features supported by 15 years

experience Only four moveable components

Pipetting arm Plate carrier Washhead Carousel

Minimal linear plate movement Reduced component travel

distance

Simplified User Interface

Everything comes to you Front-end loading

Simplified User Interface

Everything comes to you Front-end loading

Touch screen

Minimal start up/ shut down time

Minimal maintenance

User Choice of Operation

Quick and easy graphic selections for the experienced operator

Set up check lists mode for infrequent user operation

NEXGEN Four

Comprehensive Data Reduction Capabilities

Multiple results on one sample including interpretative, qualitative and quantitative

Kinetic reading options

Automatic run validation checks

Unlimited QC parameter definitions

NEXGEN Four

Future Laboratory Requirements

Multiple workstation access through laboratory network

Internet connectivity Troubleshooting Programming Software upgrades Updated product information

Remote dialup options

NEXGEN Four

Technologies Under Development

Allergy testing Tentative release – July, 2003

Immunofluorescent slide processing Tentative release – January, 2004

Agglutination automation Tentative release – January, 2004

NEXGEN Four

Automated platform with a capacity of 4 microplates - 16 tests simultaneously – up to 240 specimens with

continuous loading – touch screen – ability to expand to IFA slide prep and agglutination assays for allergy

NEXGEN Four

Truly the only open, fully supported system that utilizes all 4 plates simultaneously

NEXGEN Four

Samples CarouselTips Loader Reagents

NEXGEN Four

Samples loading capacity = 240 (120 and predilutes) Tips loading capacity = 200 + 200 Reagents containers = 44 + 44 positions Washing tanks = 3 + 3 High throughput = 360 determinations per session Filters reading range = 400 to 700 nm(n.8 filters) Reading range = 0 :3 AU

NEXGEN Four

Continuous Sample Loading

NEXGEN Four

Sample predilutions: single/serial Positive samples ID: Internal barcode reader with

bi-directional interface Positive reagents ID: optional Extractible reagents and samples racks Liquid sensor level for samples, reagents, and buffers Clot detector system for both needles Bubble detection Volumes checking system

for plastic tips application

NEXGEN Four

34 Standards and Controls

11 Reagents

NEXGEN Four

Two Independent Washheads Separate from Pipettors

NEXGEN Four

Fixed metal needle or disposable Plastic Tip to dispense samples

Reagent dispensing by Plastic tip for performance and reagent cost

Software Main Features: Real multitasking application Multi-user and multi-instruments

accessing by LAN interfacing ASTM communication for LIS/DMS Windows XP Operating System Touch screen and LAN interface Autoimmune and allergy application Remote control Web interface for service

NEXGEN FourAdaltis Diamedx Dynex DiaSorin

Griffols/ Seraquest

Feature NexGenAptus/ Mago+ DSX

Eti-Max (BioRad Evolis) Triturus

Open System X X XOpen System w/ Company Support XNumber of Plates 4 4 4 4 4

Maximum Assays per run 16 9 N/A (12/plate)N/A

(12/plate) 8

Sample Capacity

240 (w/ continuous

front loading) 120 98 240 96Different Sample Tube Sizes XFixed Metal Tip & Disposable Plastic Tip X XBubble Detection X Touch Screen XRemote Diagnostics & Troubleshooting XIFA Slide Processing XAllergy Test Capability XAgglutination Automation Capability XService Direct Mail-in Direct 3rd Party 3rd Party

NEXGEN Four is a trademark of Adaltis

Any Test. Any Combination. Any Time.