New Treatments

New drug treatments

Chronotherapy

Lung cancer vaccine

Summary

New drug treatments

- Royal Marsden Hospital (London)- Specific mutations- Sophie (11y/o) → success

Chronotherapy

- Biological clock

- Circadian rhythms

- Signs + symptoms change

→ Chronotherapy

- Treatments at most optimal time

Chronotherapy

- Inconvenients:- Best time = night (often)- Mechanisms not well known

- P53 protein:- tumour suppressor- helps prevent mutation

- Personalised treatment

Lung cancer vaccine

Introduction

- Center of Molecular Immunology- 1st lung cancer vaccine- Cimavax- Not a cure:

- survival of patient- helps immune system- therapeutic vaccine

Advantages

- Cheap to produce + store- Few side effects

- nausea- chills- fever

How does it work ?

Cancer stimulates production EGFStimulates growth of cellsTumors multiply + grow uncontrollably

EGF : epidermal growth factor → body creates antibodies

Research

- Chemotherapy + ½ vaccine

- Trials showed:- More antibodies- Lived longer- Reduces cancer symptoms

This vaccine could be used for other types of cancer

Conclusion

- A lot of new treatments

- More and more effective

- Cancer has to be found early- However, treatments more effective on some

people than on others