New requirements for high tech core facilities: Shared resources, space, technology, capital costsThe HOK Science + Technology Group l JE Dunn Construction l 21 October 2013Presenters: Randy Kray l Chirag Mistry l Kevin Brettmann

PRESENTERS

Randy Kray, AIAHOKDirector, Science & Technologyrandy.kray@hok.com

Chirag Mistry, AIAHOKSenior Laboratory Planner chirag.mistry@hok.com

Kevin BrettmannJE Dunn ConstructionDirector, Science & Technologykevin.brettmann@jedunn.com

Takeaway Objectivescore facility science and business drivers I trends and issues

infrastructure requirements l flexibility & adaptability

Core Facility Definition

A core facility is defined

as a centralized, shared

resource that provides

access to instruments

or technologies or

services, as well as

expert consultation to

investigators supported

by the core.

Inter-Disciplinary Research

Catalysts– Genomics &

Proteomics– Advanced Imaging– Nanoscale Science– Computational

Modeling – Bioengineering– Regenerative

Medicine

Convergence

BiophysicsMolecular Engineering

Transformative

Medical• Translational• Regenerative• Genomic

Materials• Synthesis• Polymer• Membranes

Engineering• Nanofabrication• Molecular• Tissue

Next…

Core Facilities

Small AnimalLarge Animal

DiscoveryEfficacy/GLP

Pathogen Free

Vivarium

MRI/PETProton/Cyclotron

CT/X-RayUltrasonic

Spectrometry

Diagnostics

Tissue banksTissue culture

Reference samplesCell Pathology

Toxicology

Specialty Lab: Pathology, Histology

Core Facilities

ResearchDevelopmentFormulation

Biochem/Small MoleculeBiologics/Large Molecule

cGMP/Pilot Scale

GMP Production

Top Down DevicesBottom Up Materials

DepositionTissue Engineering

Bioengineering

Nanofabrication Cleanrooms

SEM/TEM/STEMMRI/NMR

X-Ray CrystallographyOptical/LaserAFM/Probe

Imaging

Core Service Typology

• Resource Driven– In-vivo/Transgenic– GMP/Fabrication

• Data Driven– Bioinformatics– Genomics

• Equipment Driven– Cellular Imaging– Nuclear Imaging– Diagnostics

Cost Benchmarking

 $‐  $100  $200  $300  $400  $500  $600  $700  $800  $900

Animal Facility

Informatics

cGMP Facility (1000)

Biocontainment

Nanofabrication

Biomedical Research

Low Range

High Range

Lab Design News, 2013 Lab Construction Outlook

Funding & Cost Recovery

• “Cup-in-Hand” funding

• Strictly service cost recovery; capital/equipment cost not recoverable.

• Can make limited profit from external clients

• Equipment depreciation does not keep up with technology

ROI:

Critical to attract facultyCritical to compete for grants

Contribute F&A indirects from increasing grant revenue

CORE FACILITY DRIVERS

Key Issues

• Changing Technology– Where is the science going– Capital & equipment investment

options

• Management – Maintaining efficiency and quality– Maintaining regulatory compliance– Cost-tracking and cost recovery

• Research Integration– How does core expertise

support/integrate into research teams

– How do you develop collaborative partnerships

Trend: Consolidation

• Consolidation of cores to support different multiple funding sources– Higher utilization and less duplication– Physical or operational consolidation

• Cost of relocation• Need for proximity to research (i.e. cellular imaging)

– Optimize resources, training and technologies

Trend: Partnering & Collaboration

• Institutions specializing in core competence.

• Cryopreservation – allowing transgenic research

with other institutions without quarantine delays

– Increased need for LN2 freezer storage

Trend: Research Integration

• Existing locations often prohibit collaboration

• Core/Center strategy– Inside Center there is a component that

produces a service, e.g. Proteomics

– More complex to budget and manage cost recovery

• Service center software used for improving billing and productivity– Equipment based cores easiest to

incorporate software tool

• Some cores technologies have become a commodity and less likely to need collaboration– Flow Cytometry

Lab neighborhoods lining a central atrium

Trend: Research Colocation

Trend: Research Integration –Core Management• Technical Director

– Leads the production line– 100% dedicated – Reports to Scientific Director

• Scientific Director – Highly productive Sr. Researcher with specialty in the

service– 10-20% core payroll– External face of the core– Understands how the mouse gets built and where science

is going– Collaborates with PI/team to design project – hand over to

Tech Director

DESIGN TRENDS

Lab/Core Type Benchmarking

0%

10%

20%

30%

40%

50%

60%

70%

80%

90%

100%

FrancisCrick

Institute

UF InstituteFor

TherapeuticInnovation

USC CMSE VGTIFlorida

UT CedarsSinai

AdvancedHealthSciencesPavilion

WisconsinInstitutesfor MedicalResearch(WIMR )

Cleanroom/ Nano

GMP

Imaging

Diagnostics

Animal Core

Core Lab

Informatics

Research Office

Lab Support

Lab

Core/Non-Core

Data Driven Cores

• Genomics, Bioinformatics

• Utilizing both cloud storage and local storage

• Centralized servers with IT

• Integrated within research floors as a place of collaboration

• Sequencing is becoming a commodity – core value is in large data analysis

Lab neighborhoods lining a central atrium

Vaccine and Gene Therapy Institute

Service Driven Cores

Animal Facility Trends:• Species shift

– Increase in rats – behavioral & neuroscience– Increase in pigs and sheep – biomedical device

• Embryonic cryogenics– Reducing barrier to collaboration internally and externally– Increased need for freezer storage

• Chronic and acute procedures• Whole animal imaging technology• Centralized cagewash and disposable solutions

Case Study - Wisconsin Institutes for Medical Research (WIMR )

Imaging core serving clinical and in-vivo research

Equipment Driven Cores - Advanced Imaging Cores• Modalities

– Electron Microscopy– Crystallography – Functional imaging– High end optical and laser– Tool development

• Challenges– Low-vibration environment– Low EMI environment

• Key Questions– What tools do I need?– What is my site allowing me to

do?

Equipment Driven Cores - Nanofabrication

• Applications– Drug delivery– Biosensing– Bio MEMS– Device development

• Challenges– Hazardous processes – Low-vibration – Infrastructure– Safety issues

• Key Questions– Do I develop nanoscale

science?– What tools are needed ?

University of Southern California CMSE

NANO

IMAGING

SPECIAL LAB

THE BASEMENT IS THE NEW BEACHFRONT

INFRASTRUCTURE REQUIREMENTS

Infrastructure Requirements

• Building Structure• Floor to Floor height• Vibration

• Building Services• Ventilation• Special Gases/Water• Electrical Backup

• Isolation/Shielding• EMI• RF

• Daylight & Views• Natural Light• Light Exclusion

• Building Flow• Service Access

• Safety & Security• High Security• High Hazard• Disaster Plan

Infrastructure RequirementsSTRUCTURE

FLOO

RTO

FLO

OR H

EIGH

T

VIBR

ATIO

N

BIOINFORMATICS

CELL CULTURE

PATHOLOGY

VIVARIUM

DIAGNOSTICS

IMAGING

CLEAN ROOM /GMP

CLEAN ROOM / NANO

UNDESIREABLE

NEUTRAL

DESIREDBuilding Structure

SERVICES

INCR

EASE

D VE

NTILA

TION

SPEC

IAL G

ASES

\WAT

ER

ELEC

TRIC

AL B

ACKU

P

BIOINFORMATICS

CELL CULTURE

PATHOLOGY

VIVARIUM

DIAGNOSTICS

IMAGING

CLEAN ROOM /GMP

CLEAN ROOM / NANO

Infrastructure RequirementsBuilding Services

UNDESIREABLE

NEUTRAL

DESIRED

ISOLATION

EMI

RF

BIOINFORMATICS

CELL CULTURE

PATHOLOGY

VIVARIUM

DIAGNOSTICS

IMAGING

CLEAN ROOM /GMP

CLEAN ROOM / NANO

UNDESIREABLE

NEUTRAL

DESIREDInfrastructure RequirementsIsolation/Shielding

Infrastructure RequirementsLIGHT

NATU

RALL

IGHT

AND

VIE

W

LIGHT

EXC

LUSI

ON

BIOINFORMATICS

CELL CULTURE

PATHOLOGY

VIVARIUM

DIAGNOSTICS

IMAGING

CLEAN ROOM /GMP

CLEAN ROOM / NANO

UNDESIREABLE

NEUTRAL

DESIREDDaylight & Views

Infrastructure Requirements

SERV

ICE

ACCE

SSBIOINFORMATICS

CELL CULTURE

PATHOLOGY

VIVARIUM

DIAGNOSTICS

IMAGING

CLEAN ROOM /GMP

CLEAN ROOM / NANO

UNDESIREABLE

NEUTRAL

DESIREDAccess

Infrastructure RequirementsSECURITY

HIGH

SEC

URIT

Y

HIGH

HAZ

ARD

DISA

STER

PLA

N

BIOINFORMATICS

CELL CULTURE

PATHOLOGY

VIVARIUM

DIAGNOSTICS

IMAGING

CLEAN ROOM /GMP

CLEAN ROOM / NANO

UNDESIREABLE

NEUTRAL

DESIREDSafety & Security

Infrastructure RequirementsSTRUCTURE SERVICES ISOLATION LIGHT SECURITY

FLOO

RTO

FLO

OR H

EIGH

T

VIBR

ATIO

N

INCR

EASE

D VE

NTILA

TION

SPEC

IAL G

ASES

\WAT

ER

ELEC

TRIC

AL B

ACKU

P

EMI

RF NATU

RALL

IGHT

AND

VIE

W

LIGHT

EXC

LUSI

ON

SERV

ICE

ACCE

SS

HIGH

SEC

URIT

Y

HIGH

HAZ

ARD

DISA

STER

PLA

N

BIOINFORMATICS

CELL CULTURE

PATHOLOGY

VIVARIUM

DIAGNOSTICS

IMAGING

CLEAN ROOM /GMP

CLEAN ROOM / NANO

UNDESIREABLE

NEUTRAL

DESIRED

AN ADAPTABLE CORE PLATFORM

Core Space Flexibility – The Future Toolset

• The Challenge– Can core space be strategically planned independent

of the current tool or technology?• Address the evolving and rapidly changing technologies• Increasing demand for vibration sensitivity, power, data, etc.• Growth of chemical engineering and physics tools in

research

• The Strategy– Develop a universal core & shell strategy independent

of the research tools.

Core Space Construction Cost Trends

Building Core + Shell TI Fitout Total

Structure 11%-15% 0% 11-15%

HVAC & Controls 7-9% 8-9% 15-18%

Electrical & Security 3-5% 5-6% 9-11%

Plumbing/Fire Prot. 2-3% 3-6% 6-9%

Architecture 12-15% 20-25% 36-40%

AdaptabilityStrategy

FlexibilityStrategy

Construction Cost by Trade

0

200

400

600

800

1000

1200

ResearchLab

Vivarium Imaging Cleanroom Nano

TISpecialArchitecturePlumbingElectricalHVACStructureFoundation

Core & Shell Costs

0

50

100

150

200

250

300

350

400

450

500

ResearchLab

Vivarium Imaging Cleanroom Nano

SpecialArchitecturePlumbingElectricalHVACStructureFoundation

Core & Shell Adaptability Strategies

Option 1: Research Lab, Vivarium, Imaging, Cleanroom, NanoOption 2: Research Lab, Vivarium, Imaging, Cleanroom Option 3: Research Lab, Imaging, Vivarium (no interstitial)

0

50

100

150

200

250

300

350

400

450

500

Special

Architecture

Plumbing

Electrical

HVAC

Structure

Foundation

Data Options

Lower Level 1

Cleanroom

[VC-E, Epoxy Coated Rebar]

[VC-D]

High Performance Labs

[VC-D]

Example: William Eckhardt Research Center

• Decision making:– Core strategy needs commitment at program/ concept– TI is where there is cost flexibility - adhere to C&S strategy

Tradeline Three

• Consolidation and partnering reduces cost and maximizes your revenue

• Integrating cores physically and scientifically within your programs creates synergy and innovation

• Adaptable core space through C&S strategies provides capability for new toolsets. Needs full buy-in early in design process.

DISCUSSION