new products: antibodies, assays, small molecules, inhibitors, and proteins vol 3 2013

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  • 7/28/2019 New Products: Antibodies, Assays, Small Molecules, Inhibitors, and Proteins Vol 3 2013

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    EMD Mllprewth the expertse Calchem , Chemcn, and Upstate

    EMD Millipore is a division o Merck KGaA, Darmstadt, Germany

    PluriSTEM Human ES/iPS CellMediumFeed Less, Dscver Mre

    Traditional pluripotent stem cell culture requires everyday

    eeding, even on the weekends. PluriSTEM medium is the

    irst small molecule-based culture medium that enables

    maintenance o human pluripotent stem cells in eeder-

    ree and serum-ree conditions with less requent eeding

    and overall hands-on cell culture time, saving precious lab

    time and costs.

    PlurSTEM enets:

    Feeder-ree, serum-ree, deined cell culture system orhuman ES/iPS cells.

    Less requent cell eeding (every other day, weekend-

    ree)

    Small molecule-based ormulation. Low total protein

    and growth actor concentrations.

    High viability and prolieration in single cell passaging.

    Stem cell research solutions: more time or discovery.EMD Millipores expanding stem cell portolio eatures over 1000 unique and extensively validated cell culture products and

    characterization tools. Our optimized products provide convenient solutions to many stem cell culture challenges, so you have

    the time to ocus on your research goals. We support your entire worklow with human and mouse pluripotent and multipotent

    stem cells and media, STEMCCA cellular reprogramming tools and general cell culture growth actors, ECM proteins, specialty

    cell culture media and validated stem cell antibodies. Visit our newly launched website, where you can easily ind newly released

    products, detailed protocols, and user-riendly guides to our complete selection o stem cell research products:

    www.emdmllpre.cm/stemcells

    Epgenetcs &

    Gene RegulatnNeurscenceCancerSgnalng Cell StructureStem Cell

    ANTiboDiES, ASSAyS, SMALL MoLECULES, iNHibiToRS, AND PRoTEiNSNewVOLUME 3I2013prducts

    H9 human ES Cells grwn n PlurSTEM medum r 22 passages wtheedng 3 das per week express hgh levels Alkalne Phsphatase(b, Purple), oct-4 (C, Green), Nang (D, Red), Sx-2 (E, Green) andTRA-1-60 (F, Red). Cells were cunterstaned wth DAPi.

    A.

    C.

    E.

    b.

    D.

    F.

    Description Qty Cat. No.

    Plur iSTEM Human ES/ iPS Cell Medium 500 mL SCM130

    http://www.millipore.com/stemcell/flx4/stem-cell-researchhttp://www.millipore.com/catalogue/item/SCM130?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/SCM130?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/SCM130?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/stemcell/flx4/stem-cell-researchhttp://www.millipore.com/?cid=bios-C-epdf-1078-1306-RC
  • 7/28/2019 New Products: Antibodies, Assays, Small Molecules, Inhibitors, and Proteins Vol 3 2013

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    Reput(Ab)le.Were validated. Were guaranteed. Were published.We create the antibodies most cited by theresearch community.

    Researchers trust our antibodies because we are a thoughtul antibodyproducer, not a reseller. Were selective about oering the best antibodiesbased on the expertise o Chemicon and Upstate, internal R&D teams andcollaborations with leading institutions. We guarantee our antibodies becauseo a stringent validation process that produces the highest quality antibodieson the market today.

    We provide the most reliable, deensible, and publishable antibodyperormance, because, ultimately, its not about our reputation.Its about yours.

    Put the mst reputaleantdes t wrk r u.www.emdmllpre.cm/A

    http://www.millipore.com/antibodies/flx4/antibodieshomehttp://www.millipore.com/?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/antibodies/flx4/antibodieshomehttp://www.millipore.com/?cid=bios-C-epdf-1078-1306-RC
  • 7/28/2019 New Products: Antibodies, Assays, Small Molecules, Inhibitors, and Proteins Vol 3 2013

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    New Prduct Hghlghts

    VOLUME 3I2013

    Description Host Species Reactivity Key Applications Cat. No.

    Antdes

    Anti-PHOX2B Rabbit Hu WB ABD132

    Anti-NANOS3 Rabbit Hu WB, IH(P), IF ABD135

    Anti-PRDM16 Rabbit Hu, Rt WB, IHC, IF ABD130

    Anti-MATN1 Rabbit Hu, Rt WB, IHC, IF ABD131

    Anti-BMP15 Rabbit Ms WB, ICC ABD134

    Anti-LGI1 Rabbit Ms WB ABD136

    Anti-Nkx2.2, clone 1C11 Mouse Ms WB MABD99

    Anti-Lin28, clone PR3G10 Mouse Hu, Ms WB, ICC MABD102

    Cell Lnes

    Human Adipose

    Mesenchymal Stem Cells

    Human Cell Culture SCC038

    Human iPSC Derived Neural Progenitors Human Cell Culture SCC035

    Stem Cell & Specalt Cell Culture

    LEGENDSpeces: Hu=Human, Ms=Mouse, Rt=Rat, Bov=Bovine,Mky=Monkey, Can=Canine, Prim=Primate, Por= Porcine,Chimp=Chimpanzee, Rhe Mac=Rhesus Macaque,Ham=HamsterApplcatns: FC=Flow Cytometry, IC=Immunocytochemistry,

    IHC=Immunohistochemistry, IHC(P)=Immunohistochemistry(Paran), IF=Immunofuorescence, IP=Immunoprecipitation,WB=Western Blotting, ChIP=Chromatin IP,ELISA=Enzyme Immunoassay, DB=Dot Blot, PIA=PeptideInhibition Assay, CS=Cell Sorting, MeDIP=Methylated DNA IP

    Neural Progenitors derived

    rom human IPS cells using

    SCM110 express elevated

    levels o Nestin (Red) and

    Sox-2 (Green).

    Neural Progenitors are able to

    be urther dierentiated into

    TUJ-1 (Green) and MAP2A

    (Red) postive neurons using

    SCM111.

    For published studies using this new product,

    visit: www.emdmllpre.cm

    For publications on using these small molecules,

    visit: www.emd4scences.cm

    Human Adpse MesenchmalStem Cells (MSCs)Low passage (P2) primary human MSCs

    derived rom adipose tissue. High prolieration

    rates and longer liespan acilitatesstudies o MSC dierentiation processes,

    such as osteogenesis, adipogenesis, and

    chondrogenesis.

    Human ES/PSNeural inductn MedumTraditional methods to generate neural

    progenitor cells are lengthy and require

    cumbersome protocols. Achieve highly purehuman multipotent neural progenitors rom ES

    or iPS cells in 10 days using our potent small

    molecule-based media ormulation based on

    dual SMAD inhibition.

    HumanKne Grwth FactrsDisplaying higher biological activity compared

    to bacterially-produced recombinant growth

    actors, HumanKine proteins are produced

    in xeno-ree conditions using proprietary

    engineered human cells, expression vector,

    and cell culture media to ensure high-yield

    production o recombinant proteins with nativehuman post-translational modications, such as

    disulde bonds and glycosylation. HumanKine

    growth actors are available or many areas

    o cell biology including stem cell biology,

    immunology, cancer and other disciplines.

    Advantages HumanKne Recmnant

    Prtens

    Completely xeno-ree recombinant proteins

    Human cell-expressed protein with humanized

    post-translational protein modications such

    as glycoslylation, disulde bonds, protein

    olding

    10-100 old higher biological activity vs.

    E. coli-derived recombinant proteins

    All HumanKine growth actors are available

    in bulk 1 mg quantities.

    See Product Listing on pages 4 and 5.

    http://www.millipore.com/catalogue/item/ABD132?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABD135?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABD130?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABD131?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABD134?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABD136?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABD99?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABD102?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/SCC038?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/SCC035?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/SCM110?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/SCM111?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/?cid=bios-C-epdf-1078-1306-RChttp://www.emdmillipore.com/life-science-research/http://www.millipore.com/catalogue/item/SCM111?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/SCM110?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/SCC035?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/SCC038?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABD102?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABD99?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABD136?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABD134?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABD131?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABD130?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABD135?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABD132?cid=bios-C-epdf-1078-1306-RChttp://www.emdmillipore.com/life-science-research/http://www.millipore.com/?cid=bios-C-epdf-1078-1306-RC
  • 7/28/2019 New Products: Antibodies, Assays, Small Molecules, Inhibitors, and Proteins Vol 3 2013

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    VOLUME 3I2013

    For published studies using this new product,

    visit: www.emdmllpre.cm

    For publications on using these small molecules,

    visit: www.emd4scences.cm

    Stem Cell & Specalt Cell Culture (cntnued)

    LEGENDSpeces: Hu=Human, Ms=Mouse, Rt=Rat, Bov=Bovine, Mky=Monkey, Can=Canine, Prim=Primate, Por= Porcine,Chimp=Chimpanzee, Rhe Mac=Rhesus Macaque, Ham=HamsterApplcatns: FC=Flow Cytometry, IC=Immunocytochemistry, IHC=Immunohistochemistry, IHC(P)=Immunohistochemistry(Paran), IF=Immunofuorescence, IP=Immunoprecipitation, WB=Western Blotting, ChIP=Chromatin IP,

    ELISA=Enzyme Immunoassay, DB=Dot Blot, PIA=Peptide Inhibition Assay, CS=Cell Sorting, MeDIP=Methylated DNA IP

    Description Host Species Reactivity Key Applications Cat. No.

    Kts & Assas

    Human ES/iPS Cell Neural

    Induction Medium

    SCM110

    Human ES/iPS Cell Neurogenesis Kit SCR603

    Human ES/iPS Cell Neuronal

    Dierentiation Medium

    SCM111

    Human iPSC Derived Neural Progenitor Kit SCR131

    PluriSTEM Human ES/iPS Cell Medium

    (See Highlight on cover page)

    SCM130

    Prtens & Enzmes

    HumanKine Activin A, Human

    Recombinant Xeno-Free

    Proprietary Human

    Expression System

    Hu Recombinant

    Protein

    GF400

    HumanKine NGF, Human Recombinant

    Xeno-Free

    Proprietary Human

    Expression System

    Hu Recombinant

    Protein

    GF401

    HumanKine BMP-2, Human Recombinant

    Xeno-Free

    Proprietary Human

    Expression System

    Hu Recombinant

    Protein

    GF402

    HumanKine BMP-4, Human Recombinant

    Xeno-Free

    Proprietary Human

    Expression System

    Hu Recombinant

    Protein

    GF403

    HumanKine BMP-7, Human Recombinant

    Xeno-Free

    Proprietary Human

    Expression System

    Hu Recombinant

    Protein

    GF404

    HumanKine EPO, Human RecombinantXeno-Free Proprietary HumanExpression System Hu RecombinantProtein GF406

    HumanKine FGF basic, Human

    Recombinant Xeno-Free

    Proprietary Human

    Expression System

    Hu Recombinant

    Protein

    GF407

    HumanKine FGF-4, Human Recombinant

    Xeno-Free

    Proprietary Human

    Expression System

    Hu Recombinant

    Protein

    GF408

    HumanKine FGF-7 (KGF), Human

    Recombinant Xeno-Free

    Proprietary Human

    Expression System

    Hu Recombinant

    Protein

    GF409

    HumanKine FLT3 Ligand, Human

    Recombinant Xeno-Free

    Proprietary Human

    Expression System

    Hu Recombinant

    Protein

    GF411

    HumanKine G-CSF, Human Recombinant

    Xeno-Free

    Proprietary Human

    Expression System

    Hu Recombinant

    Protein

    GF412

    HumanKine GM-CSF, Human

    Recombinant Xeno-Free

    Proprietary Human

    Expression System

    Hu Recombinant

    Protein

    GF413

    HumanKine HGF, Human Recombinant

    Xeno-Free

    Proprietary Human

    Expression System

    Hu Recombinant

    Protein

    GF414

    HumanKine HGH, Human Recombinant

    Xeno-Free

    Proprietary Human

    Expression System

    Hu Recombinant

    Protein

    GF415

    HumanKine IFN 2A, Human

    Recombinant Xeno-Free

    Proprietary Human

    Expression System

    Hu Recombinant

    Protein

    GF416

    HumanKine IFN 2B, Human

    Recombinant Xeno-Free

    Proprietary Human

    Expression System

    Hu Recombinant

    Protein

    GF417

    HumanKine IL-1, Human Recombinant

    Xeno-Free

    Proprietary Human

    Expression System

    Hu Recombinant

    Protein

    GF418

    HumanKine IL-10, Human Recombinant

    Xeno-Free

    Proprietary Human

    Expression System

    Hu Recombinant

    Protein

    GF419

    HumanKine IL-12, Human Recombinant

    Xeno-Free

    Proprietary Human

    Expression System

    Hu Recombinant

    Protein

    GF420

    HumanKine IL-17 (IL-17A), Human

    Recombinant Xeno-Free

    Proprietary Human

    Expression System

    Hu Recombinant

    Protein

    GF421

    HumanKine IL-17F, Human Recombinant

    Xeno-Free

    Proprietary Human

    Expression System

    Hu Recombinant

    Protein

    GF422

    HumanKine IL-23, Human Recombinant

    Xeno-Free

    Proprietary Human

    Expression System

    Hu Recombinant

    Protein

    GF424

    HumanKine IL-28B, Human Recombinant

    Xeno-Free

    Proprietary Human

    Expression System

    Hu Recombinant

    Protein

    GF426

    HumanKne Actvn A(Cat. N. GF400)

    Human cell-derved recmnant grwth

    actrs, such as Actvn A, are preerred t

    acteral cell-derved prtens r stem cellresearch, ecause the exht cnserved

    psttranslatnal mdcatns and exert

    hgher lgcal actvtes. HumanKne

    Actvn A, cted n a stud emrnc

    stem cell (ESC) mRNAs1.

    b measurng mRNA levels n nne derent

    ESC lnes, the authrs und that mRNAs

    are prmsng markers r denng ptenc

    status wth hgh reslutn.

    1 Stadler b, ivanvska i, Mehta K, Sng S, Nelsn A, Tan y,Matheu J, Dar C, et al. Characterzatn mcrRNAsnvlved n emrnc stem cell states.

    Stem Cells Dev. 2010 Jul;19(7):935-50.

    PUbLiCATioN HiGHLiGHT

    http://www.millipore.com/?cid=bios-C-epdf-1078-1306-RChttp://www.emdmillipore.com/life-science-research/http://www.millipore.com/catalogue/item/SCM110?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/SCR603?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/SCM111?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/SCR131?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/SCM130?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/GF400?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/GF401?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/GF402?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/GF403?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/GF404?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/GF406?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/GF407?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/GF408?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/GF409?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/GF411?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/GF412?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/GF413?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/GF414?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/GF415?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/GF416?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/GF417?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/GF418?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/GF419?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/GF420?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/GF421?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/GF422?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/GF424?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/GF426?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/GF400?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/GF426?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/GF424?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/GF422?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/GF421?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/GF420?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/GF419?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/GF418?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/GF417?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/GF416?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/GF415?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/GF414?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/GF413?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/GF412?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/GF411?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/GF409?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/GF408?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/GF407?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/GF406?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/GF404?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/GF403?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/GF402?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/GF401?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/GF400?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/GF400?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/SCM130?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/SCR131?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/SCM111?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/SCR603?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/SCM110?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/GF400?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/GF400?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/SCM130?cid=bios-C-epdf-1078-1306-RChttp://www.emdmillipore.com/life-science-research/http://www.millipore.com/?cid=bios-C-epdf-1078-1306-RC
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    Description Host Species Reactivity Key Applications Cat. No.

    Prtens & Enzmes (cntnued)

    HumanKine IL-29, Human Recombinant

    Xeno-Free

    Proprietary Human

    Expression System

    Hu Recombinant

    Protein

    GF427

    HumanKine IL-3, Human Recombinant

    Xeno-Free

    Proprietary Human

    Expression System

    Hu Recombinant

    Protein

    GF428

    HumanKine IL-4, Human Recombinant

    Xeno-Free

    Proprietary Human

    Expression System

    Hu Recombinant

    Protein

    GF429

    HumanKine Noggin, Human

    Recombinant Xeno-Free

    Proprietary Human

    Expression System

    Hu Recombinant

    Protein

    GF434

    HumanKine OSM, Human Recombinant

    Xeno-Free

    Proprietary Human

    Expression System

    Hu Recombinant

    Protein

    GF435

    HumanKine SCF, Human Recombinant

    Xeno-Free

    Proprietary Human

    Expression System

    Hu Recombinant

    Protein

    GF438

    HumanKine TNF, Human Recombinant

    Xeno-Free

    Proprietary Human

    Expression System

    Hu Recombinant

    Protein

    GF442

    HumanKine TPO, Human Recombinant

    Xeno-Free

    Proprietary Human

    Expression System

    Hu Recombinant

    Protein

    GF443

    HumanKine VEGF165, Human

    Recombinant Xeno-Free

    Proprietary Human

    Expression System

    Hu Recombinant

    Protein

    GF445

    VOLUME 3I2013

    For published studies using this new product,

    visit: www.emdmllpre.cm

    For publications on using these small molecules,

    visit: www.emd4scences.cm

    Stem Cell & Specalt Cell Culture (cntnued)

    LEGENDSpeces: Hu=Human, Ms=Mouse, Rt=Rat, Bov=Bovine, Mky=Monkey, Can=Canine, Prim=Primate, Por= Porcine,Chimp=Chimpanzee, Rhe Mac=Rhesus Macaque, Ham=HamsterApplcatns: FC=Flow Cytometry, IC=Immunocytochemistry, IHC=Immunohistochemistry, IHC(P)=Immunohistochemistry(Paran), IF=Immunofuorescence, IP=Immunoprecipitation, WB=Western Blotting, ChIP=Chromatin IP,

    ELISA=Enzyme Immunoassay, DB=Dot Blot, PIA=Peptide Inhibition Assay, CS=Cell Sorting, MeDIP=Methylated DNA IP

    Description Details Cat. No.

    Small Mlecules & inhtrs

    AhR Antagonist

    II, SR1

    A cell-permeable purine compound that acts as a high anity AhR antagonist

    (IC50

    = 127 nM against 3 nM TCDD-induced lucierase reporter activity in HepG2

    cultures), but not a panel o 61 kinases. SR1 treatment results in enhanced and

    sustained CD34+ population in long-term prolierating/expanding cultures o cord

    blood-derived HSCs (hematopoietic setem cells) in serum-ree media containing

    Tpo, SCF, Flt3 Ligand, and IL-6 in a reversible manner.

    182706-5MG

    iPSC Induction

    Enhancer II, OAC1

    A cell-permeable pyrrolopyridinyl-benzamide compound that is reported to enhance

    the eciency o 4F/4TF- (OSKM; Oct44, Sox2, Kl4, c-Myc) driven iPSC generation

    rom MEFs cultured in either eeder cell-containing ESC media or in eeder-/serum-

    ree iSF1 media.

    500501-25MG

    Hepatic

    Dierentiation

    Inducer, SJA710-6

    A cell-permeable imidazopyridinamine compound that selectively and potently

    induces dierentiation o mesenchymal stem cells (MSCs) into hepatocyte-like cells

    (~47% at 5 M). Within 14 days o treatment with S JA710-6, the dierentiated

    cells exhibit typical morphological characteristics o hepatocytes and are able tostore glycogen, secret albumin, produce urea, and uptake LDL.

    375110-25MG

    Dopamine Receptor

    Antagonist II,

    Thioridazine, HCl

    A phenothiazine class antipsychotic and dopamine receptor (DR) antagonist that

    is reported to exhibit CSCs- (cancer stem cells) dierentiating (EC50

    9.4 M or

    v1H9) and anti-leukemic activity, without aecting non-neoplastic H9 hESC, adult

    broblast-derived iPSC, or HSPCs (hematopoietic stem-progenitor cells).

    324387-2GM

    Hh Signaling

    Antagonist XI,

    MRT-14

    A cell-permeable acylurea compound that acts as an antagonistic Smo

    ligand (IC50

    = 120 nM against 5 nM Bodipy-cyclopamine binding to murine

    Smo-transected HEK293 cells).

    373277-10MG

    InSolution Hh/Gli

    Antagonist, GANT61

    A cell-permeable hexahydropyrimidine compound that acts as downstream

    Hedgehog (Hh) pathway-selective blockers and target Gli-mediated gene

    transactivation (IC50

    ~5 M) in SAG-stimulated Shh-L2 cells, and exhibits in vivo

    antitumor ecacy.

    373403-2MG

    Wnt Agonist I in

    DMSO

    A cell-permeable, potent, and selective activator o Wnt signaling that does not

    inhibit the activity o GSK-3 (IC50

    >60 M). Shown to mimic the eect o Wnt

    and induce -catenin and TCF (T-cell ate)-dependent transcriptional activity(EC

    50= 700 nM in HEK-293T cells).

    681664-2MG

    Neuronal Di

    Inducer, Isobavachin

    "A cell-permeable, 8-prenyl favone that is shown to induce dierentiation o

    mouse embryonic stem (ES) cells into neuronal cells and astrocytes, at 100 nM.

    480748-5MG

    GSK-3b Inhibitor

    XXV

    A blood brain barrier permeable oxadiazole compound that acts as a potent,

    reversible and ATP-competitive inhibitor o GSK-3 activity (IC50

    = 17.1 nM) with

    excellent selectivity over Cdk2 (22% inhibition at 10 M). Shown to elevate liver

    glycogen levels by ~3.5- and ~4.3-old in C57BL/6N mice when dosed at 5 and

    15 mg/kg (i.p.) amounts.

    361568-10MG

    http://www.millipore.com/catalogue/item/GF427?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/GF428?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/GF429?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/GF434?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/GF435?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/GF438?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/GF442?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/GF443?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/GF445?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/?cid=bios-C-epdf-1078-1306-RChttp://www.emdmillipore.com/life-science-research/http://www.millipore.com/catalogue/item/182706-5MG?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/500501-25MG?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/375110-25MG%E0%BF%A3id=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/324387-2GM%E0%BF%A3id=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/373277-10MG?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/373403-2MG?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/681664-2MG?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/480748-5MG?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/361568-10MG?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/361568-10MG?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/480748-5MG?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/681664-2MG?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/373403-2MG?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/373277-10MG?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/324387-2GM%E0%BF%A3id=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/375110-25MG%E0%BF%A3id=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/500501-25MG?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/182706-5MG?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/GF445?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/GF443?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/GF442?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/GF438?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/GF435?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/GF434?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/GF429?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/GF428?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/GF427?cid=bios-C-epdf-1078-1306-RChttp://www.emdmillipore.com/life-science-research/http://www.millipore.com/?cid=bios-C-epdf-1078-1306-RC
  • 7/28/2019 New Products: Antibodies, Assays, Small Molecules, Inhibitors, and Proteins Vol 3 2013

    6/16

    VOLUME 3I2013

    For published studies using this new product,

    visit: www.emdmllpre.cm

    For publications on using these small molecules,

    visit: www.emd4scences.cm

    LEGENDSpeces: Hu=Human, Ms=Mouse, Rt=Rat, Bov=Bovine, Mky=Monkey, Can=Canine, Prim=Primate, Por= Porcine,Chimp=Chimpanzee, Rhe Mac=Rhesus Macaque, Ham=HamsterApplcatns: FC=Flow Cytometry, IC=Immunocytochemistry, IHC=Immunohistochemistry, IHC(P)=Immunohistochemistry(Paran), IF=Immunofuorescence, IP=Immunoprecipitation, WB=Western Blotting, ChIP=Chromatin IP,ELISA=Enzyme Immunoassay, DB=Dot Blot, PIA=Peptide Inhibition Assay, CS=Cell Sorting, MeDIP=Methylated DNA IP

    Cancer

    Description HostSpeciesReactivity Key Applications Cat. No.

    Antdes

    Anti-ABCA7 Rabbit Hu WB, IC ABC349

    Anti-AMACR, clone 2A10F3 Mouse Hu WB, IHC, IC MABC677

    Anti-ATG13 Rabbit Ms, Rt WB, IHC, IF ABC344

    Anti-BAG-1 Rabbit Hu WB, IHC, IF ABC345

    Anti-BCAR3 Rabbit Ms WB ABT336

    Anti-BFL-1 Rabbit Ms WB, IHC, IF ABC339

    Anti-Caspase 1 Rabbit Hu WB, IHC(P) 06-503-I

    Anti-Ero1, clone 2G4/12 Mouse Hu, Ms, Rt WB, IP, IF MABT376

    Anti-FAF1 Rabbit Hu, Rt WB, IHC ABC346

    Anti-Fn14 Rabbit Hu WB, IHC, IF ABC347

    Anti-GOLPH1 Rabbit Hu WB ABC340

    Anti-HAND1, clone 8E7A11 Mouse Hu WB MABC637

    Anti-HINT1 Rabbit Hu WB, IC ABC329

    Anti-HMGA1 Rabbit Hu, Ms WB ABC230

    Anti-HSPA5, clone 4E3 Mouse Hu, Rt, Ms WB, IHC MABC675

    Anti-Hyaluronan synthase 2,

    clone 2B11.1

    Mouse Hu WB, IHC(P) MABC151

    Anti-MAP3K5, clone 2E4 Mouse Hu WB, IHC, IC, FC,

    ELISA

    MABC632

    Anti-Mitousin-1, clone N111/24 Mouse Ms WB MABC295

    Anti-MORF4 Rabbit Hu WB, IHC, IF ABC336

    Anti-MTCH2 Rabbit Hu, Ms WB, IHC, IF ABC335

    Description Details Cat. No.

    Small Mlecules & inhtrs (cntnued)

    CBFbeta Activator,

    Kartogenin

    A cell-permeable biphenylcarbamoylbenzoate compound that potently induces

    the dierentiation o human mesenchymal stem cells (hMSCs) into chondrocytes

    (EC50

    = 100 nM).

    420358-25MG

    Pyrintegrin A cell-permeable pyrimidine compound that promotes the adhesion o individually

    dissociated hESCs on matrigel- or laminin-, but not gelatin-coated suraces and

    substantially reduces trypsinization-induced apoptosis, while maintaining cells

    sel-renewal ability and the pluripotency o expanded cultures or more than40 passages.

    544049-5MG

    ID-8 A cell-permeable indole compound that, when added (10 M) to murine

    D3ES ESC (embryonic stem cell) cultures in the absence o serum and MEF (murine

    embryonic broblast) eeder cells, serves as a cheaper, chemical alternative to LIF

    (1,000 units/mL) or expanding ESCs in their undierentiated state.

    405210-10MG

    Hh Signaling

    Antagonist X,

    Itraconazole

    A cell-permeable, orally available triazole-class antiungal agent that, in addition

    to its known inhibitory activity against ungal cytochrome P450 14--demethylase,

    also acts as an eective Hh signaling inhibitor (IC50

    ~ 0.8 M against SHHN-

    induced Gli transcription activity in Shh-Light2 cells) in a Ptch-independent

    manner.

    419825-250MG

    Wnt Antagonist V A cell-permeable fuorinated N,N-dialkylaminostilbene (FIDAS) compound that

    inhibits MAT2A-catalyzed SAM (S-adenosylmethionine) synthesis by targeting SAM-

    binding pocket at the MAT2A dimer interace. Shown to downregulate intracellular

    SAM level (by 64%; 36 h;10 M) and Wnt signaling in LS174 colorectal cancer.

    681677-10MG

    Stem Cell & Specalt Cell Culture (cntnued)

    http://www.millipore.com/?cid=bios-C-epdf-1078-1306-RChttp://www.emdmillipore.com/life-science-research/http://www.millipore.com/catalogue/item/ABC349?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABC677?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABC344?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABC345?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABT336?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABC339?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/06-503-I?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABT376?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABC346?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABC347?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABC340?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABC637?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABC329?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABC230?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABC675?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABC151?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABC632?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABC295?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABC336?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABC335?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/420358-25MG?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/544049-5MG?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/405210-10MG?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/419825-250MG?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/681677-10MG?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/681677-10MG?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/419825-250MG?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/405210-10MG?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/544049-5MG?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/420358-25MG?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABC632?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABC677?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABC340?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABC335?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABC336?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABC295?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABC632?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABC151?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABC675?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABC230?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABC329?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABC637?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABC340?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABC347?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABC346?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABT376?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/06-503-I?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABC339?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABT336?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABC345?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABC344?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABC677?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABC349?cid=bios-C-epdf-1078-1306-RChttp://www.emdmillipore.com/life-science-research/http://www.millipore.com/?cid=bios-C-epdf-1078-1306-RC
  • 7/28/2019 New Products: Antibodies, Assays, Small Molecules, Inhibitors, and Proteins Vol 3 2013

    7/16

    VOLUME 3I2013

    MLKL inhtr,Necrsulnamde(Cat. N. 480073)

    Prgrammed necrss, autphag and

    apptss are the three ntercnnectedpathwas that lead t prgrammed

    cell death. EMD Mllpre recentl

    made avalale Necrsulnamde, a

    small mlecule that rreversl nhts

    prgrammed necrss ndng t the

    human mxed lneage knase dman-lke

    (MLKL) prten, a newl dscvered memer

    the prgrammed necrss pathwa.

    Recentl, Sun and clleagues dented Cs86

    MLKL as the Necrsulnamde-ndng

    ste and shwed that t lcked necrss

    dwnstream RiP3 actvatn2. The als

    shwed that, n a mded HeLa cell lne

    expressng RiP3, Necrsulnamde was ale

    t lck necrss nduced TNF- and a

    Smac mmetc.

    2 Sun, L, Wang, H, Wang, Z, He, S, Chen, S, La, D, Wang,

    L, yan, J, Lu, W, Le, X, and Wang, X (2012). Mxed

    lneage knase dman-lke prten medates necrss

    sgnalng dwnstream RiP3 knase. Cell 148: 213

    -227.

    PUbLiCATioN HiGHLiGHToN SMALL MoLECULES:

    Description Details Cat. No.

    Small Mlecules & inhtrs

    Aurora Kinase

    Inhibitor XI, HOI-07

    A cell-permeable oxindole compound that selectively inhibits Aurora B, but not

    Aurora A, activity (IC50 100 nM; [ATP] = 100 M) and potently suppresses cellularhistone H3 Ser10 phosphorylation (IC50

    80% at 0.5 M) in vitro. Purity: 97% by HPLC.

    189412-10MG

    Bmi1-Ring1A E3

    Ligase Inhibitor,

    PRT4165

    A cell-permeable indandione compound that inhibits the Bmi1-Ring1A E3 complex

    ubiquitin ligase activity both in cell-ree assays (by 100% against sel- and Top2

    ubiquitination at 25 and 50 M, respectively) and in HeLa cells (by 100% against

    Bmi1 ubiquitination at 50 M). Purity: 99% by HPLC.

    203630-25MG

    CBF-Runx1

    Inhibitor II, Ro5-

    3335

    A cell-permeable benzodiazepine that suppresses CBF/Runx1-CBF

    transactivation activity (25 M; 293-0 cells) via direct bindings to both subunits

    o the heterodimeric transcription actor complex. Shown to inhibit oncogenic

    usion CBFB-MYH11-, TEL-RUNX1-, and RUNX1-ETO-, dependent leukemia cells

    prolieration (IC50

    = 1.1 to 21.7 M) in vitro. Purity: 98% by HPLC.

    219506-10MG

    InSolution

    Phorbol-12-

    myristate-13-

    acetate

    Most commonly-used phorbol ester. Extremely potent mouse skin tumor promoter.

    Activates protein kinase C in vivoand in vitro, even at nM concentrations. Promotes

    the expression o iNOS in cultured hepatocytes. Purity: 98% by HPLC

    5.00582.0001

    MLKL Inhibitor,

    Necrosulonamide

    A cell-permeable acrylamide compound that inhibits human, but not murine,

    MLKL adaptor unction via covalent modication o Cys86 and is more potent

    than Nec-1 (Cat. No. 480065) in preventing necrotic/necroptotic death in human

    HT-29 (IC50

    = 124 nM and 2 M, respectively), being ineective against necrosis/

    necroptosis in murine L929 or apoptosis in human RIP3-null Panc-1 cells.

    Purity: 95% by HPLC.

    480073-25MG

    Rho Kinase Inhibitor

    XIII, RKI-1447

    A cell-permeable pyridylthiazolyl-urea that acts as a potent, ATP site-targeting, Rho

    Kinase inhibitor (IC50

    = 14.5 and 6.2 nM against ROCK1 and ROCK2, respectively).

    Shown to be ecacious in suppressing established tumor expansion in a murine

    ErbB2 mammary cancer model (200 mg/kg/day i.p.) in vivo. Purity: 98% by HPLC.

    555562-10MG

    Cancer (cntnued)

    For published studies using this new product,

    visit: www.emdmllpre.cm

    For publications on using these small molecules,

    visit: www.emd4scences.cm

    LEGENDSpeces: Hu=Human, Ms=Mouse, Rt=Rat, Bov=Bovine, Mky=Monkey, Can=Canine, Prim=Primate, Por= Porcine,Chimp=Chimpanzee, Rhe Mac=Rhesus Macaque, Ham=HamsterApplcatns: FC=Flow Cytometry, IC=Immunocytochemistry, IHC=Immunohistochemistry, IHC(P)=Immunohistochemistry(Paran), IF=Immunofuorescence, IP=Immunoprecipitation, WB=Western Blotting, ChIP=Chromatin IP,ELISA=Enzyme Immunoassay, DB=Dot Blot, PIA=Peptide Inhibition Assay, CS=Cell Sorting, MeDIP=Methylated DNA IP

    Description HostSpeciesReactivity Key Applications Cat. No.

    Antdes (cntnued)

    Anti-PDL-1 Rabbit Hu WB, IHC(P), IF ABC324

    Anti-PD-L2 Rabbit Hu, Ms WB, IHC(P), IF ABC327

    Anti-phospho Beclin (Thr119) Rabbit Hu WB, PIA ABC118

    Anti-phospho TRADD (Ser215) Rabbit Hu WB, PIA ABC461

    Anti-RHAMM, clone 4F5.2 Mouse Hu WB MABC159Anti-RICK Rabbit Hu WB, IC ABC332

    Anti-SDF-1, clone K15C, Azide ree Mouse Hu, Ms WB, IHC,

    Neutralizing, ELISA

    MABC184

    Anti-TMEM132A Rabbit Hu, Ms, Rt WB, IHC(P) ABC148

    Kts & Assas

    In VitroVascular Permeability Imaging Assay (Green) 17-10398

    http://www.millipore.com/catalogue/item/480073-25MG?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/189412-10MG?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/203630-25MG?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/219506-10MG?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/5.00582.0001?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/480073-25MG?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/555562-10MG?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/?cid=bios-C-epdf-1078-1306-RChttp://www.emdmillipore.com/life-science-research/http://www.millipore.com/catalogue/item/ABC324?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABC327?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABC118?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABC461?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABC159?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABC332?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABC184?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABC148?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/17-10398?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABC148?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/555562-10MG?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABC159?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/555562-10MG?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/5.00582.0001?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/219506-10MG?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/203630-25MG?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/189412-10MG?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/17-10398?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABC148?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABC184?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABC332?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABC159?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABC461?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABC118?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABC327?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABC324?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/480073-25MG?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/480073-25MG?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/480073-25MG?cid=bios-C-epdf-1078-1306-RChttp://www.emdmillipore.com/life-science-research/http://www.millipore.com/?cid=bios-C-epdf-1078-1306-RC
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    8/16

    LEGENDSpeces: Hu=Human, Ms=Mouse, Rt=Rat, Bov=Bovine, Mky=Monkey, Can=Canine, Prim=Primate, Por= Porcine,Chimp=Chimpanzee, Rhe Mac=Rhesus Macaque, Ham=HamsterApplcatns: FC=Flow Cytometry, IC=Immunocytochemistry, IHC=Immunohistochemistry, IHC(P)=Immunohistochemistry(Paran), IF=Immunofuorescence, IP=Immunoprecipitation, WB=Western Blotting, ChIP=Chromatin IP,ELISA=Enzyme Immunoassay, DB=Dot Blot, PIA=Peptide Inhibition Assay, CS=Cell Sorting, MeDIP=Methylated DNA IP

    For published studies using this new product,

    visit: www.emdmllpre.cm

    For publications on using these small molecules,

    visit: www.emd4scences.cm

    VOLUME 3I2013

    Epgenetcs & Nuclear Functn

    Description HostSpeciesReactivity Key Applications Cat. No.

    Antdes

    Anti-acetyl Histone H2A.Z (Lys4/7/11), clone 299/39 Mouse Hu WB, DB MABE368

    Anti-acetyl PARP1, clone E4 Mouse Hu WB MABE365

    Anti-APC10 Rabbit Ms WB, IHC ABE608

    Anti-Apobec1 Rabbit Hu, Rt WB, IHC(P) ABE438

    Anti-CHD7 Rabbit Hu, Ms WB, IHC ABS453

    Anti-CHD-7 Rabbit Hu, Ms, Rt WB, IHC(P) ABE399

    Anti-CPEB1 Rabbit Rt WB ABE601

    Anti-CREB-1 Rabbit Hu, Rt WB, IC, ChIP ABE553

    Anti-CUX1, a.a. 1300 Rabbit Hu WB, IC ABE218

    Anti-CUX1, a.a. 861 Rabbit Hu WB, IP ABE217

    Anti-dimethyl Histone H3 (Arg17) Rabbit Hu WB, DB, IC ABE324

    Anti-dimethyl Histone H3 (Arg2) Rabbit Hu WB, DB ABE328

    Anti-dimethyl Histone H4 (Arg17) Rabbit Hu, Ms WB, DB, IC ABE323

    Cell StructureDescription Host Species Reactivity Key Applications Cat. No.

    Antdes

    Anti-GOLPH1 Rabbit Hu WB ABC340

    Anti-RHAMM, clone 4F5.2 Mouse Hu WB MABC159

    Anti-Adam17 Rabbit Hu WB, IC ABT94

    Anti-AES Rabbit Hu WB, IC, IF ABT340

    Anti-Connexin-26, clone 3B12.1 Mouse Rt, Hu WB, IHC MABT198

    Anti-EBI3 Rabbit Hu WB, IHC, IF ABT338

    Anti-ENC-1 Rabbit Ms, Rt WB, IHC ABT339

    Anti-methyl VCP/p97 (Lys315) Rabbit Hu, Ms, Rt WB, IP, IF ABT286

    Anti-MLC-2, clone 19D3.1 Mouse Hu, Rt WB, IHC MABT180

    Anti-MYBPH Rabbit Ms, Hu WB, IHC(P) ABT163

    Anti-NANOS1 Rabbit Hu, Rt WB, IHC ABT337

    Anti-Polycystin-1 Rabbit Hu, Rt, Mky WB, IHC(P), IP ABT128

    Anti-Protocadherin-8 Rabbit Hu WB, IHC(P) ABT153

    Anti-SPTBN1 Rabbit Hu WB, IHC(P) ABT184

    Anti-TRPM8 Rabbit Hu WB, IHC(P) ABT187

    Description Details Cat. No.

    Small Mlecules & inhtrs

    Rho Kinase Inhibitor

    XIII, RKI-1447

    A cell-permeable pyridylthiazolyl-urea that acts as a potent, ATP site-targeting, Rho

    Kinase inhibitor (IC50

    = 14.5 and 6.2 nM against ROCK1 and ROCK2, respectively).

    Shown to be ecacious in suppressing established tumor expansion in a murine

    ErbB2 mammary cancer model (200 mg/kg/day i.p.) in vivo. Purity: 98% by HPLC.

    555562-10MG

    Ceotaxime, Sodium

    Salt, High Purity,

    Cell Culture-Tested

    Potent -lactamase-resistant antibiotic o cephalosporin class. Active against

    Gram-positive and Gram-negative organisms, including Gram-negative anaerobes.

    Inhibits cell wall synthesis. Purity: 97% by HPLC.

    219504-1GM

    Rho Inhibitor,

    Rhosin

    A cell-permeable (quinoxalinylmethylidene-D-Tryptophanyl)hydrazide that directly

    targets Rho GEF binding domain (Kd = 354 nM or RhoA), thereby prevents Rho

    rom interacting with its GEFs (including LARG, DBL, LBC, p115 RhoGEF, and PDZ

    RhoGEF). Purity: 94% by HPLC.

    555460-25MG

    Rh inhtr, Rhsn(Cat. N. 555460)

    Rhsn, a new cell-permeale cmpund

    that drectl targets Rh GEF ndngdman (K

    d= 354 nM) and prevents Rh

    rm nteractng wth ts GEFs, s nw

    avalale rm EMD Mllpre. Rhsn

    lcks the endgenus RhA actvt and

    grwth MCF7 reast cancer cells wthut

    aectng the nn-tumrgenc epthelal

    MCF10A cells.

    Recentl, Shang and clleagues shwed

    that Rhsn speccall nhted RhA

    actvt and RhA-medated cellular

    unctn wthut aectng Cdc42 r Rac1

    sgnalng actvtes3

    . b suppressng RhAactvt, the culd nht mammar sphere

    rmatn reast cancer cells (EC50

    =

    30-50 M) and suppress nvasn

    mammar epthelal cells.

    3 Shang, X, Marchn, F, Spes, N, Eveln, C.R, Jeraek-

    Wllemsen, M, Duhr, S, Seel, W, Wrtman, M, and

    Zheng, y.Ratnal desgn small mlecule nhtrs

    targetng RhA suaml Rh GTPases. Chem. bl. 2012;

    19: 699-710.

    PUbLiCATioN HiGHLiGHToN SMALL MoLECULES:

    http://www.millipore.com/?cid=bios-C-epdf-1078-1306-RChttp://www.emdmillipore.com/life-science-research/http://www.millipore.com/catalogue/item/MABE368?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABE365?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABE608?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABE438?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABS453?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABE399?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABE601?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABE553?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABE218?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABE217?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABE324?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABE328?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABE323?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABC340?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABC159?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABT94?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABT340?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABT198?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABT338?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABT339?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABT286?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABT180?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABT163?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABT337?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABT128?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABT153?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABT184?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABT187?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/555562-10MG?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/219504-1GM?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/555460-25MG?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/555460-25MG?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABE323?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABE328?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABE324?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABE217?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABE218?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABE553?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABE601?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABE399?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABS453?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABE438?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABE608?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABE365?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABE368?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/219504-1GM?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/555562-10MG?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABT187?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABT184?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABT153?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABT128?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABT337?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABT163?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABT180?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABT286?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABT339?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABT338?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABT198?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABT340?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABT94?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABC159?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABC340?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/555562-10MG?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABC159?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABC340?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/555460-25MG?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/555460-25MG?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/555460-25MG?cid=bios-C-epdf-1078-1306-RChttp://www.emdmillipore.com/life-science-research/http://www.millipore.com/?cid=bios-C-epdf-1078-1306-RC
  • 7/28/2019 New Products: Antibodies, Assays, Small Molecules, Inhibitors, and Proteins Vol 3 2013

    9/16

    LEGENDSpeces: Hu=Human, Ms=Mouse, Rt=Rat, Bov=Bovine, Mky=Monkey, Can=Canine, Prim=Primate, Por= Porcine,Chimp=Chimpanzee, Rhe Mac=Rhesus Macaque, Ham=HamsterApplcatns: FC=Flow Cytometry, IC=Immunocytochemistry, IHC=Immunohistochemistry, IHC(P)=Immunohistochemistry(Paran), IF=Immunofuorescence, IP=Immunoprecipitation, WB=Western Blotting, ChIP=Chromatin IP,ELISA=Enzyme Immunoassay, DB=Dot Blot, PIA=Peptide Inhibition Assay, CS=Cell Sorting, MeDIP=Methylated DNA IP

    For published studies using this new product,

    visit:www.emdmllpre.cm

    For publications on using these small molecules,

    visit:www.emd4scences.cm

    Description Details Cat. No.

    Small Mlecules & inhtrs

    Daminozide A dimethylamino substi tuted succinamate that , in addit ion to i ts well known

    use as a plant growth regulator, also acts as an inhibitor against histone

    lysine demethylases KDM2A, LSD1 (KDM7A; KIAA1718), and PHF8 (IC50

    =

    1.5, 2.1, and 0.55 M, respectively). Purity: 98% by NMR.

    251635-1GM

    Histone Lysine Demethylase

    Inhibitor VIII, GSK-J4

    The H3K27me3 demethylase inhibitor GSK-J1 (Cat. No. 420204) against

    JMJD3 and UTX is made cell-permeable by ethyl ester derivatization to

    acilitate cellular delivery ([medium GSK-J4]t=0 = 30 M; [cellular GSK-J1]

    t=1h = 1.6 M). Simultaneous inhibition o cellular JMJD3 and UTX byGSK-J4 treatment is shown to block LPS-induced production o several

    proinfammatory cytokines in primary human macrophage cultures. Purity:

    98% by HPLC.

    420205-10MG

    PRMT Inhibitor VI A benzothiadiazolyl-cyclohexenylethylurea compound that binds to protein

    arginine methyltranserase 3 (PRMT3) at the dimer interace and selectively

    inhibits its activity in an allosteric manner (IC50

    = 1.6 M). Although this

    compound is cell-permeable, it is metabolically unstable and thereore not

    recommended or cell cultures or in vivoapplications. Purity: 99% by HPLC.

    539214-10MG

    Epgenetcs & Nuclear Functn (cntnued) VOLUME 3I2013

    Description HostSpeciesReactivity Key Applications Cat. No.

    Antdes (cntnued)

    Anti-dimethyl Histone H4 (Arg17), symmetric Rabbit Hu WB, DB ABE320

    Anti-DNA repair protein XRCC3 Rabbit Hu, Ms, Rt WB, IHC(P), IP ABE439

    Anti-GATA-like protein 1 Rabbit Hu WB, IHC(P) ABE421

    Anti-GLE1 Rabbit Ms WB, IHC ABE603

    Anti-Histone lysine demethylase NO66 Rabbit Hu WB ABE492Anti-HJURP, clone 144K/B1 Mouse Hu WB, IP, ChIP MABE441

    Anti-HMG-box transcription actor 1 Rabbit Hu, Rt WB, IHC(P) ABE420

    Anti-Ku70 Protein Rabbit Hu WB, IP, IHC(P) ABE558

    Anti-MeCP2, clone N227/21 Mouse Rt IHC, DB MABN538

    Anti-methylcytosine, clone 87G31 Mouse All DB, IC, MeDIP MABE345

    Anti-monomethyl Histone H3 (Arg26) Rabbit Hu, Ms WB, DB, IC ABE14

    Anti-phospho Histone H3.1/H3.2 (Ser87) Rabbit Hu, Ms, Bov WB, DB ABE155

    Anti-phospho Histone H3.3 (Thr32) Rabbit Hu WB, IP, DB ABE153

    Anti-phospho Ubiquitin-conjugating enzyme E2 A

    (Ser120), clone 7E4

    Mouse Ms, Hu WB MABE445

    Anti-phospho-Histone H3 (Ser31) Rabbit Hu, Ms WB, DB ABE152

    Anti-PRDM9 Rabbit Hu IHC(P), IP 07-2070-I

    Anti-PRMT1, clone 7D2 Rat Hu, Ms, Rt WB MABE431

    Anti-Puromycin, clone 12D10 Mouse Hu, All CS, IF, IC, WB,

    IP, IHC

    MABE343

    Anti-Puromycin, clone 17H1 Rat Hu, All WB MABE341

    Anti-Puromycin, clone 4G11 Mouse Hu, All WB, CS, IF, IC, IP MABE342

    Anti-RNA polymerase II subunit B1 (phospho-CTD

    Ser-5), clone 3E8

    Rat Ms WB, ChIP, ELISA 04-1572-I

    Anti-RPS3 Rabbit Hu, Ms, Rt WB, IP, IC, ChIP ABE391

    Anti-SATB1 Rabbit Hu WB, IHC(P), IF ABE602

    Anti-SATB2 Rabbit Hu, Ms WB, IHC(P), IF ABE600

    Anti-Thymidylate Synthase-5FU complex, clone FTS Rat Hu WB MABE370

    Anti-TNPO3 Rabbit Rt WB ABE599

    Anti-TREX1 Rabbit Hu WB, IHC, IF ABE605

    Anti-Zinc Finger Protein 217, clone 8C11 Mouse Hu WB MABE434

    ChIPAb+ Monomethyl-Histone H3 (Lys36) Rabbit Ms, Hu, Rt WB, IP, DB, ChIP 17-10498

    ChIPAb+ REST Rabbit Hu, Ms, Rt ChIP, WB 17-10456

    http://www.millipore.com/?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/?cid=bios-C-epdf-1078-1306-RChttp://www.emdmillipore.com/life-science-research/http://www.emdmillipore.com/life-science-research/http://www.millipore.com/catalogue/item/251635-1GM?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/420205-10MG?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/539214-10MG?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABE320?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABE439?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABE421?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABE603?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABE492?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABE441?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABE420?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABE558?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABN538?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABE345?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABE14?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABE155?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABE153?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABE445?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABE152?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/07-2070-I?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABE431?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABE343?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABE341?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABE342?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/04-1572-I?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABE391?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABE602?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABE600?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABE370?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABE599?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABE605?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABE434?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/17-10498?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/17-10456?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/539214-10MG?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/420205-10MG?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/251635-1GM?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/17-10456?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/17-10498?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABE434?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABE605?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABE599?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABE370?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABE600?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABE602?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABE391?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/04-1572-I?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABE342?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABE341?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABE343?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABE431?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/07-2070-I?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABE152?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABE445?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABE153?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABE155?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABE14?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABE345?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABN538?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABE558?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABE420?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABE441?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABE492?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABE603?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABE421?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABE439?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABE320?cid=bios-C-epdf-1078-1306-RChttp://www.emdmillipore.com/life-science-research/http://www.millipore.com/?cid=bios-C-epdf-1078-1306-RC
  • 7/28/2019 New Products: Antibodies, Assays, Small Molecules, Inhibitors, and Proteins Vol 3 2013

    10/16

    0

    Neurscence

    Description HostSpeciesReactivity Key Applications Cat. No.

    Antdes

    Anti-AMACR, clone 2A10F3 Mouse Hu WB, IHC, IC MABC677

    Anti-TMEM132A Rabbit Hu, Ms, Rt WB, IHC(P) ABC148

    Anti-Aquaporin 1, clone 17E12.3 Mouse Rt WB MABN136

    Anti-ATP2C1 Rabbit Ms WB, IHC ABN479

    Anti-BHMT, clone 8C11H5 Mouse Hu IHC, WB MABN679Anti-Caspr2, clone K67/25 Mouse Hu, Ms, Rt WB, IHC MABN465

    Anti-CD6 Rabbit Hu IHC ABN168

    Anti-Co-Rest/RCOR1, clone K72/8 Mouse Hu, Ms, Rt WB, IHC, IC MABN486

    Anti-CRTC2, clone 5B10 Mouse Hu WB, IC, IHC, FC MABN695

    Anti-CX3CL1 Rabbit Ms WB ABN467

    Anti-DISC1 Rabbit Ms WB ABN469

    Anti-DLX-1, clone L43/40 Mouse Hu WB, IHC MABN467

    Anti-Dopamine Transporter, clone mAb16 Mouse Rt, Ms WB MABN669

    Anti-EPAC2 Rabbit Rt, Ms WB, IHC ABN492

    Anti-EphB2, clone 2D12C6 Mouse Hu, Rt WB, IHC, IC MABN726

    Anti-FGF13 Protein, clone N91/27 Mouse Hu WB MABN484

    Anti-GluR1 Rabbit Ms, Rt, Hu WB, IHC(P) ABN241

    Anti-GOLPH2 Rabbit Rt WB, IHC ABN493

    Anti-Gs protein, alpha subunit, clone N192/12 Mouse Hu, Rt WB MABN543

    Anti-IMPDH1, clone 4F9.1 Mouse Hu, Rt, Ms WB, IHC MABN291

    Anti-IRF8, clone 8C6.2 Mouse Hu WB, IHC MABN269

    Anti-JPH3 Rabbit Hu WB, IHC, IF ABN487

    Anti-Laorin, clone N84/37 Mouse Hu WB, IHC MABN606

    Anti-LAR/PTPRF, clone N165/38 Mouse Rt WB MABN604

    Anti-Lgi1, clone N283/7 Mouse Ms, Rt WB, IHC MABN611

    Anti-MESD, clone N88/12C Mouse Hu, Rt, Ms WB, IHC MABN614

    Anti-mGluR5, clone 11D9.1 Mouse Rt, Hu WB, IHC MABN139

    Anti-mGluR5, clone N75/33 Mouse Rt, Hu, Ms WB, IHC MABN540

    Anti-Mu Opioid Receptor Rabbit Hu, Ms WB, IHC(P) AB1580-I

    Anti-Neuregulin-CRD, Type III, clone N126B/31 Mouse Hu IHC, WB MABN534

    Anti-Neuregulin-HBD, Type I/II, clone N120A/9 Mouse Hu, Ms, Rt WB, IC MABN536

    Anti-Pancortin, clone K96/7 Mouse Rt WB MABN625

    Anti-Pan-Neuroascin, clone L11A/41 Mouse Rt WB, IHC MABN621

    Anti-Pannexin-2, clone N121A/3a Mouse Rt WB, IHC MABN623

    Anti-Pan-PTPR,clone N165/43 Mouse Rt, Hu WB, IHC(P) MABN605

    Anti-Pan-QKI, clone N147/6 Mouse Rt, Ms, Hu WB MABN624

    Anti-PEN2 Rabbit Ms, Rt WB, IHC, IF ABN489

    Anti-PHOX2A Rabbit Hu, Rt WB, IHC ABN494

    Anti-PICALM Rabbit Ms WB ABN465

    For published studies using this new product,

    visit: www.emdmllpre.cm

    For publications on using these small molecules,

    visit: www.emd4scences.cm

    LEGENDSpeces: Hu=Human, Ms=Mouse, Rt=Rat, Bov=Bovine, Mky=Monkey, Can=Canine, Prim=Primate, Por= Porcine,Chimp=Chimpanzee, Rhe Mac=Rhesus Macaque, Ham=HamsterApplcatns: FC=Flow Cytometry, IC=Immunocytochemistry, IHC=Immunohistochemistry, IHC(P)=Immunohistochemistry(Paran), IF=Immunofuorescence, IP=Immunoprecipitation, WB=Western Blotting, ChIP=Chromatin IP,ELISA=Enzyme Immunoassay, DB=Dot Blot, PIA=Peptide Inhibition Assay, CS=Cell Sorting, MeDIP=Methylated DNA IP

    VOLUME 3I2013

    http://www.millipore.com/catalogue/item/MABC677?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABC148?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABN136?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABN479?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABN679?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABN465?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABN465?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABN168?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABN486?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABN695?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABN467?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABN469?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABN467?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABN669?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABN492?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABN726?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABN484?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABN241?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABN493?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABN543?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABN291?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABN269?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABN487?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABN606?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABN604?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABN611?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABN614?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABN139?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABN540?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/AB1580-I?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABN534?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABN536?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABN625?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABN621?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABN623?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABN605?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABN624?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABN489?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABN494?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABN465?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/?cid=bios-C-epdf-1078-1306-RChttp://www.emdmillipore.com/life-science-research/http://www.millipore.com/catalogue/item/ABN465?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABN465?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABN494?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABN489?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABN624?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABN605?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABN623?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABN621?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABN625?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABN536?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABN534?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/AB1580-I?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABN540?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABN139?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABN614?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABN611?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABN604?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABN606?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABN487?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABN269?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABN291?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABN543?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABN493?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABN241?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABN484?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABN726?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABN492?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABN669?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABN467?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABN469?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABN467?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABN467?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABN695?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABN486?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABN168?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABN465?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABN679?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABN479?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABN136?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABC148?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABC677?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABC148?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABC677?cid=bios-C-epdf-1078-1306-RChttp://www.emdmillipore.com/life-science-research/http://www.millipore.com/?cid=bios-C-epdf-1078-1306-RC
  • 7/28/2019 New Products: Antibodies, Assays, Small Molecules, Inhibitors, and Proteins Vol 3 2013

    11/16

    1

    Neurscence (cntnued)

    For published studies using this new product,

    visit: www.emdmllpre.cm

    For publications on using these small molecules,

    visit: www.emd4scences.cm

    LEGENDSpeces: Hu=Human, Ms=Mouse, Rt=Rat, Bov=Bovine, Mky=Monkey, Can=Canine, Prim=Primate, Por= Porcine,Chimp=Chimpanzee, Rhe Mac=Rhesus Macaque, Ham=HamsterApplcatns: FC=Flow Cytometry, IC=Immunocytochemistry, IHC=Immunohistochemistry, IHC(P)=Immunohistochemistry(Paran), IF=Immunofuorescence, IP=Immunoprecipitation, WB=Western Blotting, ChIP=Chromatin IP,ELISA=Enzyme Immunoassay, DB=Dot Blot, PIA=Peptide Inhibition Assay, CS=Cell Sorting, MeDIP=Methylated DNA IP

    VOLUME 3I2013

    Description HostSpeciesReactivity Key Applications Cat. No.

    Antdes (cntnued)

    Anti-Pink1, clone N4/15 Mouse Hu, Rt WB MABN505

    Anti-Potassium Channel Kv1.2, clone K36/15 Mouse Ms, Rt WB, IF, IHC MABN616

    Anti-Potassium channel Kv2.1, clone L80/21 Mouse Rt, Ms WB, IHC(P) MABN613

    Anti-POU6F1 Rabbit Hu, Ms WB ABN261

    Anti-PRCD Rabbit Ms IHC ABN212Anti-REEP1, clone N345/51 Mouse Ms, Rt WB, IHC MABN523

    Anti-Robo2, clone 4C6.1 Mouse Ms, Hu, Rt WB, IHC(P) MABN122

    Anti-SATB2, clone 2B12.2 Mouse Hu, Ms, Rt WB MABN98

    Anti-SH3GL1, clone K51/1 Mouse Rt WB MABN521

    Anti-SIPA1L1 Rabbit Hu, Rt WB, IHC ABN485

    Anti-Slick potassium channel, clone N11/33 Mouse Ms, Rt WB, IHC MABN510

    Anti-Snapin, clone L8/15 Mouse Hu, Rt WB, IHC MABN515

    Anti-SNAT1, clone N104/37 Mouse Hu, Ms, Rt WB, IHC MABN502

    Anti-SOX8, clone 4E4.1 Mouse Ms, Hu WB, IHC MABN268

    Anti-Spartin Rabbit Hu, Ms, Rt WB ABN402

    Anti-Spastin Rabbit Hu, Ms, Rt WB, IC ABN368

    Anti-SQSTM1, clone 20F1.1 Mouse Rt, Hu WB, IHC MABN130

    Anti-SRPX2 Rabbit Hu, Rt WB, IHC ABN488

    Anti-Stargazin, clone N245/1 Mouse Ms WB MABN517

    Anti-SUR1, clone N289/16 Mouse Ms, Rt WB, IHC MABN501

    Anti-SUR2A, clone N319A/14 Mouse Hu, Ms, Rt WB, IHC MABN512

    Anti-SUR2B, clone N323A/31 Mouse Hu, Ms, Rt WB, IHC MABN511

    Anti-Suractant Protein A Rabbit Hu, Ms WB, IHC(P) AB3420-I

    Anti-SYP1, clone 16A1.2 Mouse Hu, Rt WB, IHC(P) MABN363

    Anti-TARPg 2/4/8, clone N245/36 Mouse Ms WB MABN516

    Anti-THBS4 Rabbit Hu, Ms WB, IF ABN490

    Anti-TMEM18 Rabbit Rt, Ms WB, IHC, IF ABN471

    Anti-triphospho-PER2 (Ser662/Ser665/Ser668) Rabbit Hu WB ABN299

    Anti-TrkA, clone 6B2 Mouse Hu, Rt WB, IHC, IC MABN681

    Anti-TrpC7, clone N64A/36 Mouse Hu, Rt, Ms WB, IHC MABN522

    Anti-Trypsin-3 Rabbit Hu WB, IHC(P) ABN262

    Anti-Uncx, clone N155/9 Mouse Ms WB, IHC MABN514

    ANTI-VDAC1, clone N152B/23 Mouse Hu, Ms, Rt WB, IHC MABN504

    Anti-WAVE-1, clone K91/36 Mouse Rt, Hu, Ms WB, IHC MABN503

    Anti-WNT10B, clone 5A7 Mouse Hu IHC, WB, IF MABN717

    Prtens, Enzmes, & Reagents

    TrkC, active 14-922

    TrkC, active 14-922-K

    TrkC, active 14-922M

    FLUORO-JADE B AG310-30MG

    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N368?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABN402?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABN268?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABN502?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABN515?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABN510?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABN485?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABN521?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABN98?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABN122?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABN523?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABN212?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/ABN261?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABN613?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABN616?cid=bios-C-epdf-1078-1306-RChttp://www.millipore.com/catalogue/item/MABN505?cid=bios-C-epdf-1078-1306-RChttp://www.emdmillipore.com/life-science-research/http://www.millipore.com/?cid=bios-C-epdf-1078-1306-RC
  • 7/28/2019 New Products: Antibodies, Assays, Small Molecules, Inhibitors, and Proteins Vol 3 2013

    12/16

    2

    Sgnalng

    Ant-hCE-1(Cat. N. AbS310)

    EMD Mllpres new plclnal antd

    aganst human Carxlesterase 1 s

    eatured n a 2011 stud neurtxns4.

    The majr unctn hCE-1 s t

    metalze a varet dstnct harmul

    endgenus and exgenus cmpunds.

    Due t ts smlart n structure and

    cataltc actn wth acetlchlnesterase,

    t s an attractve target r studng the

    eects nerve agents and envrnmental

    txns.

    Recentl, Hemmert and clleagues created

    a hghl actve mutant rm hCE-1

    V146H and L363E susttutns and used

    ths antd t determne the specc

    actvt nrmal and mutant enzmes.

    The shwed that the mutant rm

    enzme reactvated aut 5 t 20-ldaster than the wld-tpe rm ater sarn

    and sman nhtn.

    4 Hemmert, AC., ott, TC., Chca, RA., Werdl, M., Edwards,JS., et al. Nerve Agent Hdrlss Actvt Desgned nta Human Drug Metalsm Enzme. PLS oNE 2011;6(3): e17441.

    PUbLiCATioN HiGHLiGHT

    For published studies using this new product,

    visit: www.emdmllpre.cm

    For publications on using these small molecules,

    visit: www.emd4scences.cm

    LEGENDSpeces: Hu=Human, Ms=Mouse, Rt=Rat, Bov=Bovine, Mky=Monkey, Can=Canine, Prim=Primate, Por= Porcine,Chimp=Chimpanzee, Rhe Mac=Rhesus Macaque, Ham=HamsterApplcatns: FC=Flow Cytometry, IC=Immunocytochemistry, IHC=Immunohistochemistry, IHC(P)=Immunohistochemistry(Paran), IF=Immunofuorescence, IP=Immunoprecipitation, WB=Western Blotting, ChIP=Chromatin IP,ELISA=Enzyme Immunoassay, DB=Dot Blot, PIA=Peptide Inhibition Assay, CS=Cell Sorting, MeDIP=Methylated DNA IP

    VOLUME 3I2013

    Description Host Species Reactivity Key Applications Cat. No.

    Antdes

    Anti-MAP3K5, clone 2E4 Mouse Hu WB, IHC, IC, FC,

    ELISA

    MABC632

    Anti-Aldh3A1 Rabbit Hu WB ABS454

    Anti-ApoA5 Rabbit Hu WB ABS443

    Anti-ARHGAP30 Rabbit Hu WB, IC, IP 07-2146

    Anti-ARHGAP36 Rabbit Hu, Ms, Rt, Mky WB, IC 07-2142

    Anti-ASAH2 Rabbit Hu WB ABS457

    Anti-CSN8 Rabbit Hu WB ABS448

    Anti-ELOVL6 Rabbit Hu WB, IHC(P), IF ABS458

    Anti-Fat Free Rabbit Ms WB ABS441

    Anti-FAT10, clone 4F1 Mouse Hu, Ms, Rt WB, IP, IC MABS351

    Anti-GNPDA2 Rabbit Hu WB, IC ABS435

    Anti-GPVI Rabbit Hu, Ms WB, IHC, IF ABS446

    Anti-hCE-1 Rabbit Hu WB ABS310

    Anti-IL-31 Rabbit Ms, Rt WB, IHC ABS455

    Anti-IL-32 Rabbit Hu WB, IHC, IF ABS433

    Anti-JMJD2B Rabbit Ms WB ABS462

    Anti-LEMD3 Rabbit Hu WB, IHC ABS460

    Anti-LZTR2 Rabbit Ms WB, IHC ABS442

    Anti-phospho-LAT Rabbit Hu WB ABS217

    Anti-PI3 Kinase p85, N-SH2 domain Rabbit Hu, Rt WB, IP ABS233

    Anti-PI3 Kinase, p85 Rabbit Hu, Rt WB, IP ABS234

    Anti-PKM2 Rabbit Hu, Ms, Mky WB, IC ABS245

    Anti-PLEKHG4B Rabbit Hu WB 07-2143

    Anti-ROCK2 Rabbit Ms WB, IHC ABS436

    Prten ResearchDescription Qty Cat. No.

    Magnetc beads

    PureProteome Protein A/G Mix Magnetic Beads 2 mL LSKMAGAG02

    PureProteome Protein A/G Mix Magnetic Beads 10 mL LSKMAGAG10

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