new product of selleck---lde225(purity>99%)
DESCRIPTION
M.Wt: 485.5Formula: C26H26F3N3O3Solubility: UnknownPurity: >99%Storage: at -20℃ 2 yearsCAS No.: 956697-53-3Biological Activity of LDE225(NVP-LDE225):LDE225(NVP-LDE225) is a novel and specific, orally bioavailable Smo inhibitor with an IC50 of 11 nM. It has been shown to potentially inhibit Hh-and Smo-dependent proliferation in vivo. It also induced the regression of preformed basaloid lesions with an IC50 of References on LDE225(NVP-LDE225):[1] Stuetz A. et al. Melanoma Research. 2010 6; 20: 40[2] Kalthoff F. et al. Melanoma Research. 2010 6; 20: 70-71TRANSCRIPT
Product Information
LDE225(NVP-LDE225) is a novel and specific, orally bioavailable Smo inhibitor with an IC50 of 11 nM. It has been shown to potentially inhibit Hh-and Smo-dependent proliferation in vivo. It also induced the regression of preformed basaloid lesions with an IC50 of <150 nmol/l and almost complete regression at 1.5 μmol/l. Topical application of a 1% LDE225(NVP-LDE225) solution to depilated skin of C57/BL6 mice completely inhibited hair growth during anagen phase as well as the expression of the Hh-pathway target genes (Gli1, Gli2, Sox9, and N-Myc) and partial inhibition was obtained when applying a 0.3% solution. [1][2]
Biological Activity
[1] Stuetz A. et al. Melanoma Research. 2010 6; 20: 40
[2] Kalthoff F. et al. Melanoma Research. 2010 6; 20: 70-71
References
Novel Kinase Inhibitors for cell signaling & oncology research
S2151 LDE225
Technical Data:M.Wt:Formula:Solubility:Purity:Storage:CAS No.:
485.5C26H26F3N3O3
Unknown99%at -20℃ 2 years956697-53-3
Notes
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℃
Synonyms: NVP-LDE225
» Smoothened (Smo)
NN OHN
O
F3CO