New Approach to the Presbyopia Treatment

Introduction

Tri-ED EDOF Concepts

Active Diffractive Optic

Semi-Apodized Optic

True TriFocality

All in One Platform

Technical Specifications

First Clinical Results

Competition – Product Segmentation

All-in-One Platform

True Trifocality with EDOF

Square Edge

Aspheric Optic

Chromatic Aberration Control Plate Haptic - MICS

Introduction

Active Diffractive Optic

Seamless Continuous Vision Balanced Near/Intermediate Addition

Pupil-Independent

Premium Material

Photo protection

Full Diffractive Trifocal Optic Enhanced by Depth of Focus Vision*

* Patent Pending New Design

New!

True Trifocal optic having superior MTF results at intermediate zones

Enhanced Depth of Focus Concept in Reviol Tri-ED Optic

1. Active Diffractive Optic

2. Semi-Apodization

3. True TriFocality

Active Diffractive Optic

Characteristic of Active Diffractive Optic Maximum Light Energy Transmission

The Reliable performance of Reviol Active-Diffractive IOL has been proven in over forty countries with thousand implantations

Enhanced Depth of Focus Concept

Active Diffractive Reviol Tri-ED

Maximum Light Transmission Effective light transmission reach up 89.1%,

It means light loss is 10.9% which is minimum value in the trifocal IOL market

.

Light Loss in Competitors

15.0% in Physiol

14.3% in Zeiss

Semi-Apodized Trifocal Optic

Benefits of Semi-Apodization Optimal Light Distribution

Enhanced Depth of Focus Concept

Semi-Apodization

Optimal Light Distribution Light is distributed through the focal area with excellent balance.

Reviol Tri-ED light splitting structure of transmitted light in 6 mm aperture:

44% for Far

28% for Intermediate

28% for Near

II. Optimum Light Distribution Comparative Test Results of transmitted light in 3mm Aperture

Models Far Intermediate Near

Reviol Tri-ED 46% 25% 29%

AT LISA tri 50% 20% 30%

Finevision 50% 17% 33%

True Trifocality

Enhanced Depth of Focus Concept

True trifocal? Appropriate Disparity between focus

True Trifocality

Appropriate Disparity Reviol Tri-ED is combined with 3.0D Near Addition and 1.5D Intermediate Addition.

Focal overlapping between light centralization in different points plays a negative role in image quality and photopic phenomena (glare/halo) problems*.

Opthalmic Optic General Information III

*Petermeier K., Messias A., Gekeler F., Szurman P. Effect of +3.00 diopter and +4.00 diopter additions in multifocal intraocular lenses on defocus profiles, patient satisfaction and contrast sensitivity. J. Cataract Refract Surg 2011; 37 (4): 720-6.

True Trifocality

and comfortable distance for the patients…

Trifocal IOL Near Addition Intermediate Addition

Reviol Tri-ED 3.00D - 42 cm 1.50D – 80 cm *

AT LISA tri 3.33D - 40 cm 1.66D –76 cm **

Finevision 3.50D - 36 cm 1.75D – 60 cm ***

Near/Intermediate Additions

* Data on file: First Clinical Findings. ** Comparison of a bifocal and a trifocal intraocular lens. E.Law R. Aggarwal H. Kasaby. Free Paper Session ESRCS 2014 London. *** Diffractive multifocal IOLs: a comparative study of Finevision versus ReSTOR 2.5 and 3.0D. K.Gundersen. Free Paper Session ESRCS 2014 London.

Active Diffractive Optic

True Trifocality

Semi Apodization

Enhanced Depth of Focus Concept

Enhanced Depth of Focus

See the MTF Results!

Enhanced Depth of Focus Concept

MTF is direct quantitative measurement of an optical system. Criteria has been determined by ISO Standard 11979.

Typical Monofocal and Bifocal IOL graphs

Enhanced Depth of Focus Concept

Reviol Tri-ED shows superior MTF values even between far-intermediate and intermediate-near area

ensures seamless continuous vision at all distance!

Enhanced Depth of Focus Concept

Comparative MTF Results at 50 lp/mm

Models Far Focus Intermediate Focus

Near Focus

Reviol Tri-ED 43 22 23

AT LISA tri 34 16 21

Finevision 36 17 20

The more resolution is The more patient is…

Unique Design of Reviol Tri-ED

Superior MTF Results

Optimum Light Distribution

Good Focal Disparity

Maximum Light Transfer

Seamless Continuous Vision

Seamless Continuous Vision

Reviol Tri-ED

All-in-One Platform!

Aspheric Optic

All Square Enhanced Edge

Efficient Photo Protection

Chromatic Aberration Control

Technical Features

First Clinical Findings

Clinical studies have been running on three different center. 26 patient had Tri-ED implantation so far

Happy patients… Happy surgeons!

Post-op Refraction Spherical Equivalent - 0.18 ± 0.38

First Clinical Findings

Visual Acuity UDVA (Uncorrected Far) -0.03 ± 0.07 UIVA (Uncorrected Intermediate) 0.16 ± 0.09 UVNA (Uncorrected Near) 0.06 ± 0.12 *LogMar Acuity

First Clinical Findings

Defocus Curve Distinctive intermediate acuity

First Clinical Findings

Good Contrast Sensitivity Results Contrast sensitivities are measured by CSV1000E, Vector Vision by glare and without glare. All eyes showed good results at 3, 6, 12 and 18 spatial frequency (cpd) Patient Satisfaction No moderate/severe glare halo problem reported. Over 95% of patients dont need glasses.

First Clinical Findings

Competition

AT LISA Tri

Trifocal & Bifocal Combination

1,66D intermediate - 3,66 near addition

Pupil-independent

Hydrophilic acrylic with hydrophobic surface

Plate haptic 6.0 mm, 11.0 mm

Competition

Competition

Finevision

Convolution steps

1,75D intermediate - 3,50 near addition

Pupil-independent

Hydrophilic acrylic (Micro F 25%, Pod F 26&)

Micro F 6,15mm – 10.75 mm

Pod F 6.0 mm – 11.40 mm

Competition

Competition

Specification Reviol Tri-ED AT LISA tri Finevision

Optic Semi-apodized Trifocal (EDOF) Pupil-Independent

Trifocal + Bifocal Combination Pupil-Independent

Trifocal Convolution Pupil-Independent

Material Hydrophilic acrylic (25%) with hydrophobic surface

Hydrophilic acrylic (25%) with hydrophobic surface

Hydrophilic acrylic (Micro F 25%, Pod F 26&)

Intermediate & Near Addition

1.5D – 3.0D 1,66D – 3,66D 1.75D – 3.50D

Diopter Range 0.0D – 32.0D with 0.5D increments

0.0D – 32.0D with 0.5D increments

10.0D – 35.0D with 0.5D increments

Competition

Spesification Reviol Tri-ED AT LISA tri Finevision

Square Edge Yes Yes

Yes

Angulation 0⁰ 0⁰ 5⁰

Haptic Plate Haptic 6.0mm – 11.0 mm (MICS)

Plate Haptic 6.0mm – 11.0 mm (MICS)

Micro F 6,15mm – 10.75 mm Pod F 6.0 mm – 11.40 mm

Light Filtration UV/Violet UV UV/Blue Light

Take-Home Message

• EDOF vision - Excellent MTF Results

• Highest value on light transmission

• Balanced intermediate1,5D / near addition3.0D: 42 cm – 80 cm

• Semi-Apodization – Light Distribution 44% F, 28% I and 28% N