New analgesic delivery system gets under the skin

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<ul><li><p>10 RESEARCH &amp; DEVELOPMENT </p><p>New analgesic delivery system gets under the skin </p><p>Effective local anaesthesia without injection is to be made possible with a new drug delivery system, report German and Spanish investigators. </p><p>Small particles consisting of an aqueous compartment surrounded by a lipid bilayer, transfersomes, allow rapid delivery of anaesthetic to the deep layers of the epidermis and dermis. The analgesic effectiveness of the preparation was equal to subcutaneous injection in rats. </p><p>In humans, complete local anaesthesia was achieved in 30 min with tetracaine transfersomes and in 90 min with lidocaine transfersomes. Local anaesthesia was maintained for over 4 hours. </p><p>The study authors conclude that transfersomes 'offer a suitable means for the noninvasive treatment of local pain on direct, topical drug application' . Planas ME. Gonzalez P. Rodriguez L. Sanchez S, Cevc G. Noninvasive percutaneous induction of topical analgesia by a new type of drug carrier. and prolongation of local pain insensitivity by anesthetic liposomes. Anesthesia and Analgesia 75: 615-621. Oct 1992 .. '1I"3/&gt;7 </p><p>31 Oct 1982 INPHARMAe ISSN 0156-270319211031-OO101$1.00c Adlalntemetlonel Ltd </p><p> /ColorImageDict &gt; /JPEG2000ColorACSImageDict &gt; /JPEG2000ColorImageDict &gt; /AntiAliasGrayImages false /CropGrayImages true /GrayImageMinResolution 150 /GrayImageMinResolutionPolicy /Warning /DownsampleGrayImages true /GrayImageDownsampleType /Bicubic /GrayImageResolution 150 /GrayImageDepth -1 /GrayImageMinDownsampleDepth 2 /GrayImageDownsampleThreshold 1.50000 /EncodeGrayImages true /GrayImageFilter /DCTEncode /AutoFilterGrayImages true /GrayImageAutoFilterStrategy /JPEG /GrayACSImageDict &gt; /GrayImageDict &gt; /JPEG2000GrayACSImageDict &gt; /JPEG2000GrayImageDict &gt; /AntiAliasMonoImages false /CropMonoImages true /MonoImageMinResolution 1200 /MonoImageMinResolutionPolicy /Warning /DownsampleMonoImages true /MonoImageDownsampleType /Bicubic /MonoImageResolution 600 /MonoImageDepth -1 /MonoImageDownsampleThreshold 1.50000 /EncodeMonoImages true /MonoImageFilter /CCITTFaxEncode /MonoImageDict &gt; /AllowPSXObjects false /CheckCompliance [ /PDFA1B:2005 ] /PDFX1aCheck false /PDFX3Check false /PDFXCompliantPDFOnly false /PDFXNoTrimBoxError true /PDFXTrimBoxToMediaBoxOffset [ 0.00000 0.00000 0.00000 0.00000 ] /PDFXSetBleedBoxToMediaBox true /PDFXBleedBoxToTrimBoxOffset [ 0.00000 0.00000 0.00000 0.00000 ] /PDFXOutputIntentProfile (sRGB IEC61966-2.1) /PDFXOutputConditionIdentifier () /PDFXOutputCondition () /PDFXRegistryName () /PDFXTrapped /False</p><p> /CreateJDFFile false /Description &gt;&gt;&gt; setdistillerparams&gt; setpagedevice</p></li></ul>