Neuropharm Exam I Questions

1. Morphine is one-half as potent and just as effective as Drug X in relieving pain, and twice as potent and effective as Drug Q. Draw dose-response curves for the three drugs.

a. Morphine’s LD50 is 2 mg/kg. Draw Drug X’s. Assume LD50 scales proportionally with potency.

b. In what instance might Drug X’s LD50 not scale in direct proportionality to morphine’s?

2. Morphine and alcohol are both metabolized by the enzyme CYP450 0A0. A woman weighing 52 kg takes 52 mg of morphine and drinks 52 mg of alcohol. Will morphine’s LD50 stay the same? If not, what is the new LD50?

a. What is the probability this woman will die?

3. Tyrosine hydroxylase (TH) requires pterin as a cofactor in order to bind its substrate tyrosine. Amino acid decarboxylase (AADC) has no cofactor, but has less affinity than TH for tyrosine. If a person is taking an MAOI, how might this affect their need for pterin?

4. The cheese effect is due to _________ of/between MAOIs and tyramine.a. Competitive antagonismb. Contraindicationc. Enzyme saturation

AADC

L-DOPA

TyramineTyrosine

TH

Neuropharm Exam I Questions

d. B and Ce. None of the above