neuro epigenetic a
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Neuroepigenetica
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No ț iuni generale
Genetică - (Neuro)- Epigenetică
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Teoria genera ţie spontane
Gregory Mandel,1865Aristotel-Francesco Redi, 1668
Walther Flemming,1879 colora-
ţia cu anilină a cromatinei,mitoza la salamandra .
No ț iuni generale
Genetică - (Neuro)Epigenetică
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No ț iuni generale
Teoria genera ţie spontane
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Gregory Mandel,1865Aristotel-Francesco Redi, 1668
Walther Flemming,1879 colora-
ţia cu anilină a cromatinei,mitoza la salamandra .
No ț iuni generale
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- Walter Sutton, 1902 – teoria
cromozomială a eredităţii
- W. Bateson, 1902- genetică
- Hans Wincler, 1920- genom
C.Waddington,1939- epigenotype,
“The total developmental system
consisting of interrelateddevelopmental pathways through
which the adult form of the an
organism is realized.”
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Conrad Waddington,1942-
Epigenetics- to refer to the study
of the “causal mechanisms” bywhich “the genes of the genotype
bring about phenotypic effects.”
O. T. Avery, C M MacLeod,
M. McCarty, (1944)- ADN
F. Crik şi J. D. Watson, 1953-
modelul acizilor nucleici
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The role of epigenetic molecular
mechanismsin regulation of CNSfunction is one of the most exciting
areas of conteporary molecular
neuroscience. This emerging field,variously referred to be neologisms
such as ”Behavioral Epigenetics” or
”Neuroepigenetics” ...
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There is clearly good reason for the excit-ement associated with studies of epigenetics
and mental health. While the inaccessibilityof the human brain is indeed a majorlimitation, it is worth noting that earlierstudies of peripheral samples contributed toour understanding of the biochemical basis
of psychiatric disease, and revealed thedegree to which the underlying biologicalprocesses were dynamically regulated by
environmental signals
-
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Thus, perhaps the most important
contribution will be the capacity to provide finally the biological basis for theintegration of nature and nurture, and
reveal the degree to which the study of one enriches our understanding of theother.
I. D Sweatt. Epigenetic Regulation in the Nervous System. Elsevier. 2013
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Organisms are defined by the
information encoded in their
genomes, and since the origin olife this information has been
encoded using a two-base-pair
genetic alphabet (A – T and G – C).In vitro, the alphabet has been
expanded to include severalnonatural base pairs Denis A. Malyshev A.D. A semi-synthetic organism with an expanded
genetic a lphabet. N AT U R E, 5 0. 2014.
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Mecanisme epigenetice
-metilarea DNA – scăderea5-metilcitozina - neoplazie
E. Hervouet, P. Hulin, F M Vallette, P. F. Cartron -Proximity ligation insitu assay for monitoring the global DNA methylation in cells.
BMC Biotechnology 2011, 11:31
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Mecanisme epigenetice
- histone deacetylase (HDAC)/
histone acetyltransferase (HAT )
-acetilarea histonei
J.A. Park et all. Differentiation and upregulation of heat shock protein
70 induced by a subset of histone deacetylase inhibitors in mouse and
human embryonic stem cells. BMB reports 2010
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Epigenetic and phenotypic changes result from a continuous pre and post nataldietary exposure to phytoestrogens in an experimental population of mice .Carlos M Guerrero-Bosagna, Pablo Sabat, Fernanda S Valdovinos, Luis EValladares and Susan J Clark BMC Physiology 2008
Emerging roles of epigenetic mechanisms in the enduring effects of early-lifestress and experience on learning and memory. Shawn McClelland, Aniko Korosi, Jessica Cope, Autumn Ivy, Tallie Z. Baram
Substance-specific and shared transcription and epigenetic changes in thehuman hippocampus chronically exposed to cocaine and alcoholZhifeng Zhoua, Qiaoping Yuana, Deborah C. Mashb, and David Goldmana,. Neurobiology of Learning and Memory 2011
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It is in this context that we would liketo consider the genomic “darkmatter,”
one of the major mysteries of the post- genome era. Perhaps no other topic in
contemporary genomics has inspiredsuch diverse viewpoints as the 95+%of the genome,previously known as
“junk DNA,” that does not code for proteins.
Transgenerational epigenetic inheritance: Focus on soma to germline informationtransfer. A. Sharma Progress in Biophysics and Molecular Biology (2012)
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enomenele emergente –
comportamentul colectiv al unuiistem, care transcende oarecum
componentele sale. Din cauzaaptului ca le transcende, el nu
e poate găsi “in” aceste
componente – si atunci unde seaflă el?
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…fizica ne spune că energia nuse pierde niciodată, că mintea şicreierul nostru- şi ca urmare,
sentimentul de viaţă - uncţionează pe bază de energie
electrică şi, ca urmare, aceastăenergie, la fel ca toate celelalte,
pur şi simplu nu pot să dispară…
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