neuregulin 1 allosterically enhances the anti-tumor ......,5&0 ,qvwlwxw gh 5hfkhufkh hq...
TRANSCRIPT
![Page 1: Neuregulin 1 allosterically enhances the anti-tumor ......,5&0 ,QVWLWXW GH 5HFKHUFKH HQ &DQFpURORJLH GH 0RQWSHOOLHU 0RQWSHOOLHU )UDQFH ,16(50 8 0RQWSHOOLHU )UDQFH 8QLYHUVLWp GH 0RQWSHOOLHU](https://reader034.vdocuments.mx/reader034/viewer/2022042323/5f0d27737e708231d438f0e5/html5/thumbnails/1.jpg)
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Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on May 15, 2017; DOI: 10.1158/1535-7163.MCT-16-0886
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on July 7, 2020. © 2017 American Association for Cancer Research. mct.aacrjournals.org Downloaded from
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on May 15, 2017; DOI: 10.1158/1535-7163.MCT-16-0886
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in vivo
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on July 7, 2020. © 2017 American Association for Cancer Research. mct.aacrjournals.org Downloaded from
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on May 15, 2017; DOI: 10.1158/1535-7163.MCT-16-0886
![Page 5: Neuregulin 1 allosterically enhances the anti-tumor ......,5&0 ,QVWLWXW GH 5HFKHUFKH HQ &DQFpURORJLH GH 0RQWSHOOLHU 0RQWSHOOLHU )UDQFH ,16(50 8 0RQWSHOOLHU )UDQFH 8QLYHUVLWp GH 0RQWSHOOLHU](https://reader034.vdocuments.mx/reader034/viewer/2022042323/5f0d27737e708231d438f0e5/html5/thumbnails/5.jpg)
in vivo
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γ
β
β
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β
β
μ μ μ
β
β
μ
μ
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μ
γ
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β
β
β
β
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β
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NRG1α, NRG1β, EGF HPRT
HPRT
in vivo
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γ
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in vivo
NRG1α
NRG1β EGF
in vitro
e.g.,
vs vs
vs
in vivo
in vitro
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in vivo
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in situ
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in vitro
in vivo
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β β
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P t
γ
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P
t
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Published OnlineFirst May 15, 2017.Mol Cancer Ther Christophe Le Clorennec, Hervé Bazin, Olivier Dubreuil, et al. its binding to HER3the non-competing anti-HER3 antibody 9F7-F11 by increasing Neuregulin 1 allosterically enhances the anti-tumor effects of
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