neu 200 molecular mechanisms of plasticity. biochemical basis of ltp
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Neu 200Molecular Mechanisms of Plasticity
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Biochemical Basis of LTP
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Calcium activation of CaM kinases
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Calcium activation of CaMKII
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LTP is reduced in Thr286A mutant mice
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LTP-induced changes in AMPA currents
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Glycine induces potentiation
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Glycine increases surface GluR1
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Phosphorylation of GluR1 by LTP
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GluR1 phosphorylation at S831
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S831 phosphorylation of GluR1is required for glycine-induced potentiation
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Model of AMPA-R regulation
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Evidence for GluR1 insertion at synapses
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CaMKII effect on synaptic responses
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Effect of S831A, S845A on LTP
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Generation of S831/845- mice
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Plasticity in S831/845- mice
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Role of GluR1 trafficking in fear conditioning: Physiology of GluR1 transfected neurons in Amygdala
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Expression of GluR1-C inhibits plasticity in Amygdala
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Expression of GluR1-C inhibits fear conditioning
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Biochemical Basis of LTP
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Spatial learning induces gene expression
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Calcium regulation of gene expression
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CaM Kinase IV activates CREB
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CaM Kinase IV phosphorylates CREB
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LTP in dnCKIV mice
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dnCaMKIV suppresses fear conditioning
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Spatial learning in dnCKIV mice