network research symposium...13th annual counteract network research symposium the new york academy...

13th Annual Network Research Symposium

June 18 – 20, 2019

Hosted by Rutgers University, New York Medical College NIH CounterACT U54 Research Center of Excellence

13th Annual CounterACT Network Research Symposium

The New York Academy of Sciences, June 18–20, 2019

U01s, 25-minute talks

R21s, R43s, and Interagency Projects, 15-minute talks

U54s, 75-minute talks

DAY 1 Tuesday June 18, 2019

7:30 AM Registration, Continental Breakfast, and Set-up for Poster Session 1

8:00 AM Welcome and Opening Remarks

Marie Samanovic-Golden, PhD, The New York Academy of Sciences

Jeffrey D. Laskin, PhD, Rutgers University

David A. Jett, PhD, National Institute of Neurological Disorders and Stroke (NINDS), Director, CounterACT Program

8:15 AM

Keynote Addresses Moderator: Jeffrey D. Laskin, PhD, Rutgers University

8:15 – 8:45 am

Mass Casualty Threats and Consequences

Clifton R. Lacy, MD, Rutgers Robert Wood Johnson Medical School, Rutgers University School of Communications and Information

8:45 – 9:15 am

Nerve Agent Poisoning: Lessons Learned from the Salisbury Incident

Professor Peter Blain, Newcastle University, United Kingdom

9:15 – 9:45 am

Verification, Diagnostics and Treatment of Nerve Agent Poisoning

Professor Dr. Horst Thiermann, Bundeswehr Institute of Pharmacology and Toxicology, Munich, Germany

9:45 AM Coffee Break

10:10 AM Continuing Education

Moderator: David Balshaw, PhD, NIEHS

Continuing Education

Moderator: David A. Jett, PhD, NINDS

Continuing Education

Moderator: Hung Tseng, PhD, NIAMS

10:10 – 10:45 am

Principles of Pulmonary Toxicology

Howard Kipen, MD, MPH, Rutgers University

10:10 – 10:45 am

Principles of Neurotoxicology

Andrew Gow, PhD, Rutgers University

10:10 – 10:45 am

Principles of Skin and Ocular Toxicology

Joshua Gray, PhD, US Coast Guard Academy

10:50 AM U01s, R21 and Reports

RESPIRATORY AGENTS


NEUROLOGICAL AGENTS

Moderator: David A. Jett, PhD, NINDS

DERMAL AGENTS

Moderator: Hung Tseng, PhD, NIAMS

10:50 – 11:15 am

Targeting Cardiopulmonary Calpains to Mitigate Toxicity of Halogen Gases

Shama Ahmad, University of Alabama at

Birmingham

10:50 – 11:15 am

Antiglutamatergic Therapy to Protect the Immature Brain Against Nerve Agents

Maria Braga, Henry Jackson Foundation for

the Advancement of Military Medicine

10:50 – 11:15 am

Blocking Arsenicals-Induced Cutaneous Injury

Mohammad Athar, University of Alabama at

Birmingham

11:15 – 11:40 am

Optimization of AEOL10150 Treatment of Sulfur Mustard-Induced Lung Toxidrome in a Pig Model

Brian Day, National Jewish Health

11:15 – 11:40 am

Identification of Novel Brain-Penetrating Phenoxyalkyl Pyridinium Oxime Countermeasures”

Janice Chambers, Mississippi State

University

11:15 – 11:40 am

Translation of Novel and Repurposed Drugs to Address the Acute and Late Effects of Mustard Exposure

Kurt Q. Lu, Northwestern University

11:40 – 12:05 pm

Bromine Inhalation-Induced Lung Injury: Novel Mechanisms and Treatment Strategies

Sadis Matalon, University of Alabama at

Birmingham

11:40 – 12:05 pm

Advanced Development of Drugs to Mitigate Parathion Intoxication

Jason Richardson, Florida International University and Jeffrey Laskin, Rutgers

University

11:40 – 11:55 am

Phosgene Oxime Cutaneous Toxicity and Mechanisms to Identify Therapeutic Targets

Neera Tewari-Singh, Michigan State University

11:55 – 12:10 pm

Development of a Rodent IV Sulfur Mustard Exposure Model for Systemic Injury Evaluation

Phillip Beske, Battelle Memorial Institute

12:10 PM Working Lunch: Meet the Experts

1:30 PM R21s and Interagency Reports

RESPIRATORY AGENTS


NEUROLOGICAL AGENTS

Moderator: Shardell Spriggs, PhD, NINDS

OCULAR AGENTS

Moderator: Houmam Araj, PhD, NEI

1:30 – 1:45 pm

Antidotes Against Hydrochloric Acid-Induced Chronic Lung Injury

John Catravas, Old Dominion University

1:30 – 1:45 pm

Epigenetic Attenuation of Long-Term Effects of Nerve Agents

Doodipala Reddy

Texas A&M University Health Sciences Center

1:30 – 1:45 pm

Understanding and Treating Tissue-Specific Pathologies That Distinguish Among Acute, Chronic and Delayed-Onset Mustard Gas Injuries

Patrick McNutt, MRICD

1:45 – 2:00 pm

An Approach Toward Antidotes for Phosphine

Linda Pearce

University of Pittsburgh

1:45 – 2:00 pm

Toxin-Specific and Symptomatic Drugs in Combination with Novel Neuroprotectants Effectively Counteract DFP-Induced Long-Term Neurotoxicity

Thimmasettappa Thippeswamy

Iowa State University

1:45 – 2:00 pm

Turbo Eye Drops to Treat Ocular Toxicity and Blindness from Sulfur Mustard

Rajiv Mohan

University of Missouri School of Medicine

2:00 – 2:15 pm

RiVax: Protection Against Ricin Intoxication

Oreola Donini

Soligenix

2:00 – 2:15 pm

Computationally Designed Stable Artificial Phosphotriesterases for Detoxification of Organophosphorus Agents

Jin Montclare, New York University

2:00 – 2:15 pm

High Throughput Screening to Identify Therapeutic Targets for Vesicant Ocular Injury

Jeffrey Koenig, MRICD

2:15 – 2:30 pm

Phosphine Poisoning: Model Development, Toxicity, Mechanisms, and Treatment

Benjamin Wong, MRICD

2:15 – 2:30 pm

The Carboxylesterase Knockout Mouse as a Model to Evaluate the Efficacy of Delayed Medical Countermeasures Against Soman Exposure

Lucille Lange, MRICD

2:15 – 2:30 pm

In Vivo Evaluation of Validated Targets for Vesicant and Toxic Industrial Chemical Ocular Injury

Jeffrey Koenig, MRICD

2:30 – 2:45 pm

Evaluation of Mesenchymal Stem Cells as Therapeutics for Sulfur Mustard-Induced Lung Injury

Dana Anderson, MRICD

2:30 – 2:45 pm

CounterACT Neurotherapeutics Screening (CNS) Program

Hilary McCarren, PhD, MRICD

Jay Spampanato, University of Utah

2:30 – 2:45 pm

Nanomedicine Approach to Counter Acrolein-Induced Blindness and Toxicity to the Eye

Rajiv Mohan, University of Missouri

2:45 – 3:00 pm

A Pediatric Rodent Model for Development of MCMs Against Inhalation Exposure

Heidi Hoard-Fruchey, MRICD

2:45 – 3:00 pm

Therapeutic Evaluation of Agonists & Positive Allosteric Modulators of CB1 and CB2 to Mitigate Acute & Chronic Neurological Effects of Soman Exposure

Brittany Winner, MRICD

2:45 – 3:00 pm

Mechanisms of Vesicant-Induced Ocular Injury

Laurie Joseph, Rutgers University

3:15 PM Trainees: 4 slides/ 4 minute presentations, 1 minute discussion

Moderator: Lauren Aleksunes, PharmD, PhD, DABT, Rutgers University

3:15 - 3:20 pm

Live animal molecular imaging techniques demonstrate that anti-tumor necrosis factor-α antibody mitigates lung injury induced by nitrogen mustard

Alexa Murray (mentor: Dr. Debra Laskin)

Rutgers University

3:20 – 3:25 pm

Impaired gas exchange and lung inflammation following acute cutaneous lewisite exposure

Shajer Manzoor (mentor: Dr. Aftab Ahmad)

The University Alabama at Birmingham

3:25 – 3:30 pm

Susceptibility of cardiac specific SERCA knockout to bromine

Juan Xavier Masjoan Juncos (mentor: Dr. Shama Ahmad)

The University Alabama at Birmingham

3:30 - 3:35 pm

A mouse model of acute DFP intoxication

Jonas Calsbeek (mentor: Dr. Pamela J Lein)

University of California, Davis

3:35 – 3:40 pm

Comparative analysis of transcription factor-target networks associated with lipopolysaccharides and arsenicals induced inflammation

Bharat Mishra (mentor: Dr. Mohammad Athar)

The University of Alabama at Birmingham

3:40 – 3:45 pm

Investigating mechanisms of foam cell formation in nitrogen mustard-induced lung injury by RNA-seq

L Cody Smith (mentor: Dr. Jeffrey D Laskin)

Rutgers University

3:50 PM Working Reception: Meet the Experts and Poster Session 1

6:00 PM Day 1 Adjourns (Poster Session 1 Poster Removal)

DAY 2 Wednesday June 19, 2019

7:30 AM Registration, Continental Breakfast, and Set-up for Poster Session 2

8:00 AM U54 Center Presentations

Moderator: Pertti (Bert) Hakkinen, PhD, NLM Moderator: David A. Jett, PhD, NINDS

8:00-9:15 am

Development of Antidotes for Toxic Gases

Carl White, University of Colorado Denver

8:00-9:15 am

Novel Anticonvulsant and Neuroprotective Therapies for TETS and Organophosphorus Intoxication

Pamela Lein, University of California Davis


9:40 AM RESPIRATORY AGENTS

Moderator: David Yeung, PhD, NIAID

NEUROLOGICAL AGENTS

Moderator: Kristopher Bough, PhD, NIDA

9:40 – 10:05 am

Functional Genomics of Chemical-Induced Acute Lung Injury

George Leikauf, University of Pittsburgh

9:40 – 10:05 am

Novel Counteract Agents to Reduce Mortality and Morbidity Following Organophosphate Status Epilepticus

Robert Delorenzo, Virginia Commonwealth University

10:05 – 10:30 am

TIE2 Activation for the Treatment of Chemical-Induced Acute Lung Injury

Christopher Kontos, Duke University

10:05 – 10:30 am

Anticholinergic and Antiepileptic Therapies for Chlorine Toxicity

Livia Veress, University of Colorado Denver

10:30 – 10:55 am

Extracellular RNA as Therapeutic Target after Toxic Chemical Inhalation

Aftab Ahmad, University of Alabama at Birmingham

10:30 – 10:55 am

Accelerated AChE Reactivator Design by Mechanistic Neutron Scattering Studies

Zoran Radić, University of California San Diego

10:55 – 11:10 am

Antidotes Against Mustard-Induced Chronic Lung Injury

John Catravas, Old Dominion University

10:55 – 11:20 am

Molecular Imaging of Chemical Threats and Countermeasures

Charles Thompson, University of Montana

11:20 – 11:35 am

Identification of Novel Brain Penetrating Oxime Antidotes for Phorate Toxicity

Janice Chambers and Edward Meek, Mississippi State University

11:35 AM Working Lunch: Meet the Experts and Poster Session 2

1:35 PM

Keynote Addresses Moderator: Laurie B. Joseph, PhD, Rutgers University

1:35 – 2:05 pm

Working with the U.S Food and Drug Administration to Obtain Approval of Products Under the Animal Rule

Jules T. Mitchel, PhD, MBA, Target Health Inc.

2:05 – 2:25 pm

Building and Implementation of Quality Systems for Medical Countermeasures

Judith W. Laney, PhD/Pennie E. Hylton, PhD, Biomedical Advanced Research and Development Authority (BARDA)

2:30 PM U54 Center Presentations

Moderator: David Balshaw, PhD, NIEHS Moderator: Hung Tseng, PhD, NIAMS

2:30-3:45 pm

University of Alabama Research Center of Excellence in Arsenicals

Mohammad Athar, University of Alabama at Birmingham

2:30-3:45 pm

Rutgers University CounterACT Research Center of Excellence- Developing Drugs to Treat Vesicant-Induced Lung, Skin and Ocular Injury

Jeffrey D. Laskin, Rutgers University

6:30 PM Trainee Awards Dinner Cruise — boarding at 6:30 PM, boat departs at 7:00 PM

DAY 3 Thursday June 20, 2019

7:30 AM Continental Breakfast and Registration

8:00 AM 8:00 – 8:20 am

NIH Core Service- CounterACT Preclinical Development Facility (CPDF) Program

Carol Green, PhD, SRI International

8:20 – 8:40 am

Drug Product Formulations: Planning Efficient Formulation Transition from Discovery to First in Human Trials

Michael Mesa/Matthew Robben, PhD, Mesa Science Associates

8:40 – 9:00 am

NINDS Strategies for Enhancing the Diversity of Neuroscience Researchers

Michelle Jones-London, PhD, Office of Programs to Enhance Neuroscience Workforce Diversity, NIH-NINDS

9:05 AM

U01s, R21s, and Interagency Reports

RESPIRATORY AGENTS


METABOLIC AGENTS

Moderator: Gennady Platoff, PhD, NIAID

9:05 – 9:30 am

Thioredoxin Mimicry: Novel Treatment of Toxicant-Mediated Inhalational Lung Injuries

Garry J. Southan, Radikal Therapeutics, Inc.

9:05 – 9:20 am

Advanced Preclinical Development of Novel Cyanide Medical Countermeasures

Gary Rockwood, MRICD

9:30 – 9:55 am

CIALIS® Reverses Halogen-Induced Injury to Pregnant Animals and Their Offspring

Sadis Matalon, University of Alabama at Birmingham

9:20 – 9:35 am

Development of Intranasal Delivery of Novel Cyanide Medical Countermeasures

Dennean Lippner, MRICD

9:35 – 9:50 am

Mitochondrial Targeted Biofuels as Countermeasures Against Chemical Threats

Todd Kilbaugh, The Children's Hospital of Philadelphia


10:10 AM U01s, R21s, R43, and Interagency Reports

NEUROLOGICAL AGENTS

Moderator: Shardell Spriggs, PhD, NINDS

METABOLIC AGENTS

Moderator: Gennady Platoff, PhD, NIAID

10:10 – 10:35 am

Neurosteroids as a Standard Medical Countermeasure for OP Poisoning

Kelvin Gee, University of California Irvine

10:10 – 10:25 am

Investigating Therapeutics for Toxicological Effects of Sodium Fluoroacetate Metabolic Poisoning

Bryan McCranor, MRICD

10:35 – 10:50 am

Solubility, Toxicity, and Organoleptics of Several Lead Chemical Threats: Comprehensive Chemical Assessment to Inform Modeling, Prioritization, and Medical Countermeasure Efficacy Testing

Nathaniel Rice, MRICD

10:25 – 10:50 am

Sodium Tetrathionate as a Cyanide Antidote

Gerry Boss, University of California San Diego

10:50 – 11:05 am

Preclinical Development of Adenosine Agonists for Countering Nerve Agent-Induced Seizure and Neuropathology

Tsung-Ming Shih and Thaddeus Thomas, MRICD

10:50 – 11:15 am

Methylene Blue as an Antidote Against Hydrogen Sulfide Intoxication

Philippe Haouzi, Pennsylvania State University, Hershey Medical

Center

11:05 am – 11:20 am

Selecting and Optimizing Successful Treatments Against Ingested Lethal Doses of TETS in an Established Rat Oral Consumption Model

Noah Rauscher, MRICD

11:15 – 11:40 am

Cyanide/Azide Detoxification by New Cobalt Complexes and Nitric Oxide Donors

James Peterson, University of Pittsburgh

11:20 – 11:35 am

Therapeutics for Reducing Long-Term Inflammatory Consequences Following Cessation of Nerve Agent-Induced Seizures

Jacob Skovira, MRICD

11:40 – 12:05 am

Development of the Vitamin B12 Analog Cobinamide as a Hydrogen Sulfide Antidote

Gerry Boss, University of California San Diego

11:35 – 11:50 am

A Rat Model to Guide the Standard of Care for In-Hospital Treatment of Nerve Agent-Induced Status Epilepticus

Hilary McCarren, MRICD

11:50 – 12:05 pm

Zwitterionic Oxime (RS194B) to Reverse Advanced Symptoms and Lethality of Organophosphate Pesticide Exposure

Yvonne Rosenberg, Plantvax, Inc.

12:15 PM Working Lunch/Continuing Education

An Overview of the Preclinical Development Process: From Idea to IND in One Day

SRI International

2:15 PM Conference Adjourns

Poster Session 1 (Tuesday 6/18) Poster Session 2 (Wednesday 6/19) Setup: starting at 7:30am Setup: starting at 7:30am Poster Session & Networking: 3:50 – 6:00pm Poster Session & Networking: 11:35am – 1:35pm

Cellular Agents/Metabolic Agents Poster Session

CounterACT Awardee PI

Presenter (other than PI)

Poster Number Title and Authors

2 Boss, Gerry C.1

Development of the Vitamin B12 Analog Cobinamide as a Hydrogen Sulfide Antidote Chan A, Brenner M, Burney T, Lee J, Mahon S, Mukai D, Saber T, Mayer S, Bebarta V, Hendry-Hofer T, Witeof A, Haouzi P, Tubbs N, Boss G

2 Boss, Gerry C.2 Sodium Tetrathionate as a Cyanide Antidote Chan A, Brenner M, Burney T, Lee J, Mahon S, Mukai D, Saber T, Mayer S, Bebarta V, Hendry-Hofer T, Witeof A, Dretchen K, Mesa M, Robben M, Green C, Boss G

2 Haouzi, Philippe C.3

Effects of Methylene Blue After Hydrogen Sulfide Intoxication: Large Mammals and In Vitro Studies Haouzi P, Tubbs N, McCann M, Cheung J

2 Kilbaugh, Todd C.4 Mitochondrial Targeted Biofuels as Countermeasures Against Chemical Threats

Piel S, Janowska J, Ehinger J, Karlsson M

2 Lippner, Dennean C.5

Development of Intranasal Delivery of Novel Cyanide Medical Countermeasures Lippner DS, Hildenberger DH, Rhoomes MO, Winborn JN, Schmitt C, O’Keefe E, Culp W, Shichor I, Shahaf D, Rockwood GA

2 McCranor, Bryan C.6

Investigating Therapeutics for Toxicological Effects of Sodium Fluoroacetate Metabolic Poisoning McCranor BJ, Cox V, Racine M, Jennings L, Pueblo E, Dukes A, Tressler J, Tuet W, Stone S, Pierce S, Hartog M, Thompson L, Ma K, Hoard-Fruchey H, Wong B

2 Peterson, James C.7 Toward the Amelioration of Azide Toxicity

Frawley K, Totoni S, Pearce L, Peterson J

2 Rockwood, Gary

C.8

Advanced Preclinical Development of Novel Cyanide Medical Countermeasures Lippner DS, Rhoomes MO, Hildenberger DH, Winborn JN, Bebarta V, Hendry-Hofer T, Logue BA, Petrikovics I, Thompson D, McDonough J, Dixon H, Rockwood GA


Neurological Agents Poster Session




1 Braga, Maria Taiza Figueiredo N.1

Antiglutamatergic Therapy to Protect the Immature Brain Against Nerve Agents Figueiredo TH, Aroniadou-Anderjaska V, Apland JP, Furtado M, Braga MF

1 Chambers, Janice

N.2 Identification of Novel Brain-penetrating Oxime Antidotes for Phorate Toxicity Chambers J, Gwaltney S, Meek E, Ross M

2 Chambers, Janice

Edward Meek N.3

Identification of Novel Brain-penetrating Phenoxyalkyl Pyridinium Oxime Countermeasures Meek E, Chambers J

1 CNS Program Bryan Barker N.4 CounterACT Neurotherapeutics Screening (CNS) Program Barker B, McCarren H, Jackson C, Hornung E, McDonough J

1 CNS Program Jay Spampanato N.5

A Model of Organophosphate-Induced Electrographic Seizures in Rats to Evaluate Delayed Treatment with Novel Anticonvulsants Spampanato J, Smolik M, Dudek EF

2 Delorenzo, Robert N.6

Novel Counteract Agents to Reduce Mortality and Morbidity Following Organophosphate Status Epilepticus DeLorenzo RJ, Deshpande, LD, Blair, R

2 Gee, Kelvin Tim Johnstone N.7

Modulators of Extrasynaptic α4β3δ GABAA Receptors Reverse Electrographic Status Epilepticus in the Rat After Acute Organophosphorus Poisoning Hogenkamp DJ, McCarren H, McDonough J, Johnstone T, Gee KW

1 Lange, Lucille Brenda Marrero-Rosado

N.8

The Carboxylesterase Knockout Mouse as a Model to Evaluate the Efficacy of Delayed Medical Countermeasures Against Soman Exposure Schult C, Marrero-Rosado B, Stone M, Kundrick E, Walker K, O'Brien S, de Araujo Marrero-Rosado B, de Araujo Furtado M, Schultz C, Stone M, Walker K, Kundrick E, Lumley L

1 Laskin, Jeffrey Yi-Hua Jan N.9

Effects of Vitamin C on the Ability of Menadione to Protect Against Parathion-induced Neurotoxicity Jan YH, Richardson JR, Houssain MM, Laskin JD






2 McCarren, Hilary N.10

Rat Models to Guide the Standard of Care for In-Hospital Treatment of Nerve Agent- induced Status Epilepticus McCarren H, Morgan J, Wilson S, Hundertmark K, Eisen M, Nguyen D, Belski H, Hornung E, Travis B, Bounader K, Jackson-Piercy C, Coppola J, Mills S

2 Moffett, Mark Noah Rauscher N.11

Selecting and Optimizing Successful Treatments Against Ingested Lethal Doses of Tetramethyleneddisulfotetramine (TETS) in an Established Rat Oral Consumption Model Moffett M, Rice N, Rauscher N

1 Montclare, Jin K

N.12 Computationally Designed Stable Artificial Phosphotriesterases for Detoxification of Organophosphorus Agents Katyal P, Renfrew D, Montclare J

2 Radić, Zoran Andrey Kovalevsky N.13

Accelerated AChE Reactivator Design by Mechanistic Neutron Scattering Studies Kovalevsky A, Cheng X, Blumenthal D, Gerlits O, Kong X, Taylor P, Radić Z

1 Reddy, Samba N.14 Epigenetic Attenuation of Long-Term Effects of the Nerve Agent Soman Reddy DS, Wu X, Kuruba R

2 Rice, Nathaniel N.15

Solubility, Toxicity, and Organoleptics of Several Lead Chemical Threats: Comprehensive Chemical Assessment to Inform Modeling, Prioritization, and Medical Countermeasure Efficacy Testing Rice N, Rauscher N, Moffett M, Myers T

2 Rosenberg, Yvonne N.16

Ability of the Zwitterionic Oxime (RS194B) to Protect Against Lethal Organophosphate Insecticide Exposure in Macaques Rosenberg Y, Sullivan D, Ooms T, Rajendran N, Mao L, Jiang X, Lees J, Urban L, Momper J, Taylor P

2 Skovira, Jacob N.17 Therapeutics for Reducing Long-term Inflammatory Consequences Following Cessation of Nerve Agent-induced Seizures Skovira J, Johnson E, Chandler J, Spriggs D






1 Thippeswamy, Thimmsettappa N.18

Inducible Nitric Oxide Synthase Inhibitor, 1400W, Mitigates DFP-induced Long-term Neurotoxicity in the Rat Model Putra M, Sharma S, Gage M, Gasser G, Hinojo-Perez A, Olson A, Gregory-Flores A, Puttachary S, Wang C, Anantharam V, Thippeswamy T

2 Thompson, Chuck

John Gerdes N.19 Molecular Imaging of Chemical Threats and Countermeasures

Blecha J, Chao CK, Gerdes J, Hayes T, Huynh T, Thompson C, VanBrocklin H, Zinn K

2 Tsung-Ming, Shih N.20

Preclinical Development of Adenosine Agonist for Countering Nerve Agent-induced Seizure and Neuropathology Tsung-Ming S, Thaddeus T

1

UC Davis U54 Lein, Pamela Rogawski, Michael

Ashish Dhir N.21

Combined Allopregnanolone, Perampanel and Midazolam Treatment Terminates DFP-induced Status Epilepticus in Rats Dhir A, Bruun DA, Guignet M, Tsai YH, Gonzalez EA, Tancredi DJ, Harvey DJ, Lein PJ, Rogawski MA

1

UC Davis U54 Lein, Pamela Rogawski, Michael

Dorota Zolkowska N.22

Comparison of the Efficacy of Diazepam, Midazolam and Allopregnanolone for Termination of Tetramethylenedisulfotetramine (TETS)-induced Status Epilepticus in Mice Zolkowska D, Boosalis C, Harvey DJ, Tancredi DJ, Rogawski MA, Lein PJ

1 UC Davis U54 Pessah, Isaac

Wei (Wayne) Feng

N.23

Subtype Selective Nicotinic Cholinergic Receptor (nAChR) Antagonist is Sufficient to Normalize Abnormal Electrical Spike Activity Triggered by DFP in the Rat Hippocampal Slice Preparation Feng W, Pessah IN

1 UC Davis U54 Pessah, Isaac

Shane Antrobus N.24

Development of a Human Neuronal Network Model for Screening Novel OP Nerve Agents Antrobus S, Cherednychenko G, Pessah IN

1 UC Davis U54 Wulff, Heike

Brandon Pressly N.25 The Binding Site of TETS in the Pore of the α2b3γ2L GABA-A Receptor

Pressly B, Lee RD, Pessah IN, Wulff H






1 UC Davis U54 Wulff, Heike N.26

Comparison of the Toxicokinetics of the Convulsants Picrotoxinin and TETS Pressly B, Vasylieva N, Barnych B, Singh V, Bruun DA, Hwang SH, Chen YJ, Lein PJ, Hammock BD, Wulff H

2 Veress, Livia Taya Hanna N.27

Evaluation of the Neurological Effects of High-Dose Chlorine Gas Hanna T, Truitt A, Basiouuny M, Bloomquist L, Phillips C, Johnson C, Rioux J, White CW, Raol Y, Veress LA

1 Winner, Brittany N.28

Therapeutic Evaluation of Agonist, Antagonist and Positive Allosteric Modulators of Cannabinoid Receptors Types 1 and 2 to Mitigate Acute, Chronic Neurological Effects of Soman Exposure Winner B, O'Brien S, Wolfe S, Kelly K, Pagarigan K, Phung C, Dubee P, Bodner P, Eisen M, Nelson M, McNutt P

Respiratory Agents Poster Session




1 Ahmad, Aftab

Nithya Mariappan P.1

Modulating Extracellular Nucleic Acids and its Downstream Target Prolongs Survival of Rats Exposed to Aerosolized CEES Mariappan N, Wei CC, Zafar I, Manzoor S, Ahmad S, and Ahmad A

1 Ahmad, Shama

Juan Xavier Masjoan Juncos

P.2 Calpain Inhibition Reverses Bromine-induced Cardiotoxicity Juncos J, Shakil S, Bradley W, Powell P, Zafar I, Mariappan N, Wei C, Ford D, Dell’Italia L, Ahmad A, Ahmad S

1 Anderson, Dana P.3

Evaluation of Mesenchymal Stem Cells as Therapeutics for Sulfur Mustard-induced Lung Injury Holmes W, Zimmerman D, Lewis A, Rogers A, Hudson J, Clark O, Varney T, Anderson D

1 Catravas, John

Margarita Marinove P.4 Antidotes Against HCl-induced Chronic Lung Injury

Marinova M, Sopolov P, Dimitropoulou C, Colunga Biancatelli R, Catravas JD


Respiratory AgentsPoster Session




1 Catravas, John Pavel Solopov P.5 Antidotes Against Mustard-induced Chronic Lung Injury

Solopov P, Marinova M, Dimitropoulou C, Catravas, JD

1 Day, Brian Patrick Ng P.6 Optimization of AEOL10150 Dosing Formulation in Swine Ng P, Hendry-Hofer T, Huang J, Witeof A, Bebarta V, Day B

1 Hoard-Fruchey, Heidi P.7

A Pediatric Rodent Model for Development of Medical Counter Measures Against Inhalation Phosphine Exposure Hoard-Fruchey H, Hartog M, Thompson L, Ma K, Nealley E, Bearden I, Holmes W

1 Kontos, Christopher P.8 Tie2 Activation for the Treatment of Phosgene-induced Acute Lung Injury

McCord T, Orr T, Herbert J, Padgett M, Peters K, Kontos C

1 Matalon, Sadis Tamas Jilling P.9 CIALIS® Reverses Halogen Induced Injury to Pregnant Animals and Their Offspring

Jilling T, Lambert J, Addis D, Dell’Italia LJ, Matalon S

1 Matalon, Sadis P.10 Bromine Inhalation Induced Lung Injury: Novel Mechanisms and Treatment Strategies Aggarwal S, Ford D, Mobley J, Ahmad I, Doran S, Matalon S

1 Pearce, Linda P.11 The Antidotal Action of Some Gold(I) Complexes Toward Phosphine Toxicity Garrrett K, Frawley I, Totoni S, Bae Y, Pearce L, Peterson J

1 Southan, Garry P.12 Thiol and Selenium-containing Compounds for the Treatment of Phosgene-mediated Inhalational Lung Injury Southan G, Salzman A, Cuzzocrea S

1 UC Denver U54 Boss, Gerry P.13

Development of Antidotes Against Methylmercaptan Poisoning Boss G, Adriano AC, Brenner M, Burney T, Lee J, Mahon S, Mukai D, Saber T, Saidan M, Bebarta V, Hendry-Hofer T, Witeof A

1 UC Denver U54 Brenner, Matthew

Yusi Miao P.14

Photonics Technologies for Diagnostics and Antidote Development in Toxic Gas Inhalation Studies Miao Y, Mahon SB, Boss GR, Chen Z, White CW, Brenner M


Respiratory AgentsPoster Session




1 UC Denver U54 Veress, Livia

Jacqueline Rioux P.15

Swine Model of High Dose Sulfur Mustard Inhalation, and Improved Outcome After Rescue with Alteplase Treatment Rioux J, Brace R, Doyle-Eisele M, Henrey-Hofer T, Truitt A, Phillips C, Mesenbrink K, McGrath T, Hanna T, Johnson C, Bebarta V, Garlick R, Bloomquist L, Weber W, Kracko D, White C, McDonald J, Veress L


Matthew McGraw P.16 Pulmonary Endothelial Injury After In Vitro Mustard Vapor Exposure

McGraw, M, Kim S, Carl W. White C, Veress L


Carly Johnson P.17

Pulmonary Hypertension as a Chronic Pulmonary Sequelae in Rats After Sulfur Mustard Inhalation Johnson C, Phillips C, Truitt A, Hanna T, Bloomquist L, Basiouny M, Goodman J, Garlick R, White C, Veress L

1 UC Denver U54 White, Carl Heidi Nick P.18

Fibrinolytic Therapy for Acute Methyl Isocyanate Inhalation Nick H, Rioux J, Phillips C, Truitt A, Johnson C, Hanna T, Garlick R, Bloomquist L, Croutch C, Peters E, Sosna W, Anantharam P, Veress L, White C

1 Wong, Benjamin P.19

Phosphine Poisoning: Model Development, Toxicity, Mechanisms, and Treatment Wong B, Tuet WY, Tressler J, Jennings L, Pierce S, Racine M, Pueblo E, Dukes A, Deley Cox V, Stone S, McCranor B


Vesicating Agents Poster Session




2 Athar, Mohammad

Purushotham Guroji V.1

IL-17 Signaling is Involved in the Vesicant Action of Arsenicals: Studies with Phenylarsine Oxide Guroji P, Li C, Srivastava RK, Rana M, Xu H, Weng Z, Athar M

2 Athar, Mohammad Changzhao Li V.2 Modulation of Vesicant Action of Arsenicals by Small Molecules

Li C, Srivastava R, Guroji P, Liu W, Muzaffar S, Khan J, Weng Z, Lu H, Kashyap M, Athar M

2 Koenig, Jeffrey V.3

In Vivo Evaluation of Validated Targets for Vesicant and Toxic Industrial Chemical Injury Koenig J, Gomez A, Altvater A

2 Lu, Kurt V.4 Vitamin D Combination Treatment to Ameliorate Skin Damaging Effects of Nitrogen Mustard Biyashev D, Onay U, Lu K

2 McNutt, Patrick V.5

Understanding and Treating Tissue-specific Pathologies that Distinguish Among Acute, Chronic and Delayed-onset Mustard Gas Injuries McNutt P, Kelly K, Lyman M, Nelson M, Eisen M, Nguyen D, Bodner P, Ondeck C, Dubee P, Hamilton T, Hall N

2 Mohan, Rajiv Lynn Martin V.6

Acrolein’s Toxicity to the Eye and GCLC’s Potential to Limit Corneal Damage Martin L, Gupta S, McDaniel M, Balne P, Tripathi R, Rodier J, Sinha P, Giuliano E, Hesemann N, Chaurasia S, Mohan R

2 Mohan, Rajiv

James Landreneau V.7

Topical Ophthalmic Drops to Counteract Sulfur Mustard Induced Corneal Damage Landreneau J, Tripathi R, Balne P, Martin L, Sinha P, Giuliano E, Sinha N, Giuliano E, Hesemann N, Chaurasia S, Mohan R

2 Ruff, Albert V.8 HTS to Identify Therapeutic Targets for Vesicant Ocular Injury Ruff A, Gomez A, Altvater A

2 Rutgers U54 Laskin, Jeffrey

Gabriella Wahler V.9 Sulfur Mustard Exposure Disrupts Dermal and Epidermal Structures in Porcine Skin

Wahler G, Croutch C, Kang J, Casillas RP, Laskin DL, Heck DE, Laskin JD, Joseph LB







Alexa Murray V.10 Live Animal Molecular Imaging Techniques Demonstrate That Anti-Tumor Necrosis Factor-α Antibody Mitigates Lung Injury Induced by Nitrogen Mustard Murray A, Venosa A, Malaviya R, Adler D, Yurkow E, Gow A, Laskin JD, Laskin DL


Marion Gordon V.11 Deposition of Provisional Matrix Components After Ocular Nitrogen Mustard Injury

Po I, Rodrigues AS, Hahn RA, Peihong Z, Gerecke DR, Gordon MK


Rama Malaviya V.12

Natural History of Inhaled Sulfur Mustard Poisoning in Rats Malaviya R, Rancourt R, Abramova E, Bellomo A, Croutch CR, Roseman J, Peters E, Casillas RP, Amuzie C, Laskin JD, Laskin DL


Vasanthi Sunil V.13 Protective Role of Spleen-derived Myeloid Cells in a Mouse Model of Vesicant-induced Lung Injury and Oxidative Stress Sunil VR, Ali G, Cervelli JA, Vayas KN, Goedken M, Malaviya R, Laskin JD, Laskin DL


L Cody Smith V.14 Investigating Mechanisms of Foam Cell Formation in Nitrogen Mustard-induced Lung Injury by RNA-seq Smith LC, Venosa A, Gow AJ, Laskin JD, Laskin DL


Christophe Guillon V.15

Optimization Homologging: In Search of Improved Variants of a Clinical Lead (AIDNX, NDH4338) to Mitigate Mustard-induced Injury Guillon C, Velgus CF, Saxena J, Lacey CJ, Joseph LB, Wahler G, Heck DE, Heindel ND, Laskin JD

2 Tewari-Singh, Neera

V.16

Evaluation of phosgene Oxime Toxicity and Related Mechanism from its Cutaneous Exposure Goswami DG, Jones BM, Sosna W, Tuttle RS, Roseman JM, Anantharam P, Wright HN, Klein J, Croutch CR, Agarwal R, Tewari-Singh N

2 UAB U54 Agarwal, Anupam

Amie Traylor V.17 Arsenical Induced Kidney Injury Due to Cutaneous Exposure Traylor A, Esman S, Black L, Eckenrode H, Fan C, Srivastava R, Iqbal M, Gunars O, Curtis L, George J, Athar M, Agarwal A






2

UAB U54 Ahmad, Aftab and Antony, Veena

Shajer Manzoor V.18 Characterizing Acute Lung Injury Caused by Cutaneous Exposure to Lewisite

Manzoor S, Mariappan N, Zafar I, Wei C, Agarwal A, Ahmad S, Athar M, Antony V, Ahmad A

2 UAB U54 Antony, Veena

Ranu Surolia V.19

Murine Model of Delayed Lung Injury in the Survivors of Cutaneous Exposure to Arsenicals Surolia R, Fujun Li, Wang Z, Kashyap M, Srivastava RK, Shameel M, Mariappan N, Iqbal M, Zafar I, Weng Z, Agarwal A, Athar M, Ahmad A, Antony V

2 UAB U54 Athar, Mohammad

Wenwen Liu V.20 Pathogenesis of Vasicant Arsenicals in Murine and Porcine Models Liu W, Li C, Srivastava RK, Guroji P, Kashyap M, Weng Z, Ahmad A, Antony V, Agarwal A, Athar M


Ritesh Kumar Srivastava V.21

BRD4-dependent Chromatin Remodeling Profile of Arsenicals in the Skin Srivastava R, Li C, Guroji P, Muzaffar S, Khan J, Liu W, Weng Z, Lu H, Kashyap M, Ahmad A, Antony V, Agarwal A, Athar M


Mahendra Kashyap V.22

Lipidomics of Arsenicals-Treated Skin: Role of Lipid Metabolism in Skin Inflammation and Tissue Injury Kashyap M, Li C, Srivastava R, Waseem M, Shameel M, Guroji P, Ahmad A, Antony V, Agarwal A, Athar M


Others Poster Session Group Presenter Poster

Number Title and Authors

1 CPDF Program Carol Green O.1 Preclinical Development of Chemical Countermeasures

Wang J, Green C

1 OSPIDA/ NIAID Dave Yeung O.2 Bibliometric Analysis of Chemical Countermeasures Research Program

Nye J, Zane AC, Zoha S, Ghosh D

1 OSPIDA/ NIAID Dave Yeung O.3 Portfolio Analysis of the Chemical Countermeasure Research Program (CCRP)

Walton L, Calder T

14th Annual NIH CounterACTNetwork Research Symposium

June 23-25, 2020

UC Davis Conference CenterDavis, CA

Located in the heart of Northern California,the university campus is only a short 15minute drive from Sacramento, California'sstate capital and is a day trip away fromworld renowned destinations like SanFrancisco, Napa, Lake Tahoe and Yosemite.

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University of California, Davis

This symposium would not be possible without the generous

support of our sponsors

Funding for this Symposium was made possible, in part, by a grant from the National Institutes of

Health (U54 AR055073). The views expressed in this symposium do not necessarily reflect the

official policies of the Department of Health and Human Services or endorsement by the U.S.

Government.

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