network medicine - integrating drugs, targets, diseases and side-effects
DESCRIPTION
LEO Pharma, Ballerup, Denmark, November 5, 2008TRANSCRIPT
![Page 1: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/1.jpg)
Lars Juhl Jensen
Network medicineIntegrating drugs, targets, diseases and side-effects
![Page 2: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/2.jpg)
Lars Juhl Jensen
Network medicineIntegrating drugs, targets, diseases and side-effects
![Page 3: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/3.jpg)
Lars Juhl Jensen
Network medicineIntegrating drugs, targets, diseases and side-effects
![Page 4: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/4.jpg)
![Page 5: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/5.jpg)
![Page 6: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/6.jpg)
what went wrong?
![Page 7: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/7.jpg)
phase 0
![Page 8: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/8.jpg)
before you do anything
![Page 9: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/9.jpg)
a good problem
![Page 10: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/10.jpg)
a good idea
![Page 11: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/11.jpg)
dynamics of complexes
![Page 12: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/12.jpg)
microarray data
![Page 13: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/13.jpg)
protein interactions
![Page 14: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/14.jpg)
de Lichtenberg, Jensen, et al., Science, 2005
![Page 15: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/15.jpg)
phosphorylation networks
![Page 16: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/16.jpg)
mass spectrometry data
![Page 17: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/17.jpg)
sequence motifs
![Page 18: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/18.jpg)
functional associations
![Page 19: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/19.jpg)
Linding, Jensen, Ostheimer et al., Cell, 2007
![Page 20: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/20.jpg)
Linding, Jensen, Ostheimer et al., Cell, 2007
![Page 21: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/21.jpg)
the problem
![Page 22: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/22.jpg)
new uses for old drugs
![Page 23: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/23.jpg)
drug–drug network
![Page 24: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/24.jpg)
shared target(s)
![Page 25: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/25.jpg)
chemical similarity
![Page 26: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/26.jpg)
Tanimoto coefficients
![Page 27: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/27.jpg)
![Page 28: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/28.jpg)
![Page 29: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/29.jpg)
similar drugs share targets
![Page 30: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/30.jpg)
only trivial predictions
![Page 31: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/31.jpg)
the idea
![Page 32: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/32.jpg)
chemical perturbations
![Page 33: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/33.jpg)
phenotypic readouts
![Page 34: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/34.jpg)
drug treatment
![Page 35: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/35.jpg)
side effects
![Page 36: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/36.jpg)
the implementation
![Page 37: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/37.jpg)
information on side effects
![Page 38: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/38.jpg)
package inserts
![Page 39: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/39.jpg)
![Page 40: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/40.jpg)
text mining
![Page 41: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/41.jpg)
side-effect ontology
![Page 42: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/42.jpg)
backtracking
![Page 43: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/43.jpg)
![Page 44: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/44.jpg)
side-effect correlations
![Page 45: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/45.jpg)
![Page 46: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/46.jpg)
GSC weighting
![Page 47: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/47.jpg)
side-effect frequencies
![Page 48: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/48.jpg)
![Page 49: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/49.jpg)
raw similarity score
![Page 50: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/50.jpg)
![Page 51: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/51.jpg)
p-values
![Page 52: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/52.jpg)
![Page 53: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/53.jpg)
side-effect similarity
![Page 54: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/54.jpg)
chemical similarity
![Page 55: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/55.jpg)
![Page 56: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/56.jpg)
reference set
![Page 57: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/57.jpg)
drug–target pairs
![Page 58: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/58.jpg)
![Page 59: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/59.jpg)
drug–drug pairs
![Page 60: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/60.jpg)
score bins
![Page 61: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/61.jpg)
benchmark
![Page 62: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/62.jpg)
![Page 63: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/63.jpg)
fit calibration function
![Page 64: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/64.jpg)
![Page 65: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/65.jpg)
probabilistic scores
![Page 66: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/66.jpg)
the results
![Page 67: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/67.jpg)
drug–drug network
![Page 68: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/68.jpg)
ATC codes
![Page 69: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/69.jpg)
![Page 70: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/70.jpg)
categorization
![Page 71: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/71.jpg)
![Page 72: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/72.jpg)
![Page 73: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/73.jpg)
![Page 74: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/74.jpg)
map onto score space
![Page 75: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/75.jpg)
![Page 76: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/76.jpg)
the experiments
![Page 77: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/77.jpg)
20 drug–drug relations
![Page 78: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/78.jpg)
in vitro binding assays
![Page 79: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/79.jpg)
![Page 80: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/80.jpg)
![Page 81: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/81.jpg)
![Page 82: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/82.jpg)
Ki<10 µM for 11 of 20
![Page 83: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/83.jpg)
cell assays
![Page 84: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/84.jpg)
9 of 9 showed activity
![Page 85: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/85.jpg)
![Page 86: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/86.jpg)
the big picture
![Page 87: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/87.jpg)
STITCH
![Page 88: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/88.jpg)
![Page 89: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/89.jpg)
protein–chemical network
![Page 90: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/90.jpg)
![Page 91: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/91.jpg)
primary experimental data
![Page 92: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/92.jpg)
activity screens
![Page 93: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/93.jpg)
Fedorov et al., PNAS, 2007
![Page 94: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/94.jpg)
protein interactions
![Page 95: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/95.jpg)
Jensen & Bork, Science, 2008
![Page 96: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/96.jpg)
gene coexpression
![Page 97: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/97.jpg)
![Page 98: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/98.jpg)
genomic context
![Page 99: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/99.jpg)
Korbel et al., Nature Biotechnology, 2004
![Page 100: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/100.jpg)
literature mining
![Page 101: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/101.jpg)
![Page 102: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/102.jpg)
curated knowledge
![Page 103: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/103.jpg)
Letunic & Bork, Trends in Biochemical Sciences, 2008
![Page 104: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/104.jpg)
different formats
![Page 105: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/105.jpg)
different identifiers
![Page 106: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/106.jpg)
different reliability
![Page 107: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/107.jpg)
benchmarking
![Page 108: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/108.jpg)
von Mering et al., Nucleic Acids Research, 2005
![Page 109: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/109.jpg)
373 genomes
![Page 110: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/110.jpg)
Jensen et al., Nucleic Acids Research, 2008
![Page 111: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/111.jpg)
transfer by orthology
![Page 112: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/112.jpg)
combine all evidence
![Page 113: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/113.jpg)
![Page 114: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/114.jpg)
Acknowledgments
Monica Campillos
Michael Kuhn
Christian von Mering
Anne-Claude Gavin
Peer Bork
![Page 115: Network medicine - Integrating drugs, targets, diseases and side-effects](https://reader035.vdocuments.mx/reader035/viewer/2022062703/554e8a36b4c90573338b49bc/html5/thumbnails/115.jpg)
http://larsjuhljensen.wordpress.com