Neoplasia p.1

SYLLABUS:

RBP(Robbins Basic Pathology) Chapter:Neoplasia

DefinitionsNomenclatureCharacteristics of benign and malignant neoplasmsEpidemiologyCarcinogenesis

Neoplasia p.1

63 Squamous cells papilloma286 CIN (slides with CIN I and CIN II)90 CIN III242 Squamous cell carcinoma (larynx)68 Adenocarcinoma (large intestine)69 Small cell lung carcinoma (= SCLC)

-multiple projections

-with a central central fibrovascular cores

-covered by a typical, stratified squamous epithelium

Squamous cells papilloma

Squamous cells papilloma

Squamous cells papilloma

CIN

Cytological featuresCytological features::

- loss in the uniformity of the individual cells- loss in the uniformity of the individual cells- considerable pleomorphism - considerable pleomorphism - hyperchromatic - hyperchromatic and enlarged and enlarged nucleinuclei- more abundant more abundant mitotic figuresmitotic figures also in abnormal also in abnormal locations within epitheliumlocations within epithelium

Loss of the typicalLoss of the typical architecturalarchitectural orientatio orientation of n of cellscells

Intact basal membrane

review a few slides as they differ in grade (CIN 1 and CIN 2)

Cervical epithelium without CIN

CIN

CIN

CIN

- normal epithelium totally replaced by immature atypical cells, exhibiting no surface differentiation

- intact basal membrane

CIN III

CIN III

CIN III

Squamous cell carcinoma (keratinizing) (larynx)

groups of malignant cells of epithelial origin with marked focal dyskeratosis infiltrating soft tissues

Squamous cell carcinoma (keratinizing) (larynx)

Squamous cell carcinoma (keratinizing) (larynx)

Adenocarcinoma (large intestine)

Cytologically malignant columnar cells forming neoplastic glands, often cribriform, with central necrosis.

Differentiation may range from tall, columnar cells to undifferentiated, frankly anaplastic masses.

Adenocarcinoma (large intestine)

Adenocarcinoma (large intestine)

Small cell lung carcinoma (= SCLC)

The epithelial cells are small, with scant cytoplasm, ill-defined cell borders, finely granular nuclear chromatin (salt and pepper pattern), and absent or inconspicuous nucleoli. The cells are round, oval, and spindle-shaped, and nuclear molding is prominent. In general, tumor cells are smaller than small resting lymphocytes. The mitotic count is high. The cells grow in clusters that exhibit neither glandular nor squamous organization. Necrosis is common and often extensive. Grading is inappropriate, since all small cell carcinomas are high grade.

Small cell lung carcinoma (= SCLC)

Small cell lung carcinoma (= SCLC)