1

What is NCCTG?What is NCCTG?What is NCCTG?What is NCCTG?

North Central Cancer Treatment GroupNorth Central Cancer Treatment Group

Jan C. Buckner, MDJan C. Buckner, MD

Group ChairGroup Chair

June 17, 2003June 17, 2003

North Central Cancer Treatment GroupNorth Central Cancer Treatment Group

Jan C. Buckner, MDJan C. Buckner, MD

Group ChairGroup Chair

June 17, 2003June 17, 2003

2

PurposePurposePurposePurpose

• To improve duration and quality of life To improve duration and quality of life by performing high quality clinical by performing high quality clinical trials in the community settingtrials in the community setting

• To improve understanding of cancer To improve understanding of cancer biology and biological consequences biology and biological consequences of treatmentof treatment

• To improve methodology for To improve methodology for conducting clinical trialsconducting clinical trials

• To improve duration and quality of life To improve duration and quality of life by performing high quality clinical by performing high quality clinical trials in the community settingtrials in the community setting

• To improve understanding of cancer To improve understanding of cancer biology and biological consequences biology and biological consequences of treatmentof treatment

• To improve methodology for To improve methodology for conducting clinical trialsconducting clinical trials

3

NCCTG DistinctivesNCCTG DistinctivesNCCTG DistinctivesNCCTG Distinctives

• Community-basedCommunity-based

• Single Research BaseSingle Research Base

• Intertwined with MCCC and Mayo Intertwined with MCCC and Mayo FoundationFoundation

• Community-basedCommunity-based

• Single Research BaseSingle Research Base

• Intertwined with MCCC and Mayo Intertwined with MCCC and Mayo FoundationFoundation

4

OrganizationOrganizationOrganizationOrganization

• MembersMembers• GovernanceGovernance

• MayoMayo• Administrative InfrastructureAdministrative Infrastructure• Scientific ExpertiseScientific Expertise

• MembersMembers• GovernanceGovernance

• MayoMayo• Administrative InfrastructureAdministrative Infrastructure• Scientific ExpertiseScientific Expertise

5

FundingFundingFundingFunding

• NCINCI

• MayoMayo

• ContractsContracts

• MembersMembers

• PhilanthropyPhilanthropy

• NCINCI

• MayoMayo

• ContractsContracts

• MembersMembers

• PhilanthropyPhilanthropy

6

Criteria for MembershipCriteria for MembershipCriteria for MembershipCriteria for Membership

• AccrualAccrual

• Data quality and timelinessData quality and timeliness

• AccrualAccrual

• Data quality and timelinessData quality and timeliness

7

Categories of MembershipCategories of MembershipCategories of MembershipCategories of Membership

• CCOPCCOP

• ConsortiumConsortium

• AffiliateAffiliate

• CCOPCCOP

• ConsortiumConsortium

• AffiliateAffiliate

8

ParticipantsParticipantsParticipantsParticipants

• 1247 physicians1247 physicians

• 424 sites424 sites

• 1247 physicians1247 physicians

• 424 sites424 sites

June 16, 2003

CP1041821-2

AKAK

WAWA

ORORIDID

MTMT

SaskatchewanSaskatchewan

WYWY

UTUTNVNV

CACA

AZAZ NMNM

COCO

NENE

SDSD

NDNDMNMN

MOMOKSKS

FLFL

NCNC

MIMI

KYKY

OHOH

WVWV VAVA

PAPA

NYNY

MDMDDEDE

NJNJCTCT

RIRI

MAMA

MEME

NHNHVTVT

IAIAILIL

WIWI

OntarioOntario

DCDC

HIHI

MexicoMexico

GAGA

TXTX LALA

ARARALAL

TNTN

MSMS

OKOK SCSC

ININ

CP1041821-1

AKAK

WAWA

ORORIDID

MTMT

SaskatchewanSaskatchewan

WYWY

UTUTNVNV

CACA

AZAZ NMNM

COCO

NENE

SDSD

NDNDMNMN

MOMOKSKS

FLFL

NCNC

MIMI

KYKY

OHOH

WVWV VAVA

PAPA

NYNY

MDMDDEDE

NJNJCTCT

RIRI

MAMA

MEME

NHNHVTVT

IAIA

1717

2222

55

77

22

33 ILIL

WIWI

OntarioOntario

DCDC99

2828

2929

55 1919

6161

3311

37373030

11

11

2

HIHI

MexicoMexico

11

GAGA88

TXTX LALA

ARARALAL

TNTN

MSMS

OKOK

2277

1010

11

1010

SCSC11

ININ1

11

What are our research What are our research components?components?

What are our research What are our research components?components?

12

Funded ProgramsFunded ProgramsFunded ProgramsFunded Programs

• BrainBrain

• BreastBreast

• GIGI

• LungLung

• Cancer ControlCancer Control

• BrainBrain

• BreastBreast

• GIGI

• LungLung

• Cancer ControlCancer Control

13

Working GroupsWorking GroupsWorking GroupsWorking Groups

• MelanomaMelanoma

• ProstateProstate

• HematologyHematology

• MelanomaMelanoma

• ProstateProstate

• HematologyHematology

14

Discipline-Oriented Discipline-Oriented CommitteesCommittees

Discipline-Oriented Discipline-Oriented CommitteesCommittees

• Novel TherapeuticsNovel Therapeutics

• Quality of LifeQuality of Life

• Gender and Ethnic DiversityGender and Ethnic Diversity

• Patient AdvocacyPatient Advocacy

• Novel TherapeuticsNovel Therapeutics

• Quality of LifeQuality of Life

• Gender and Ethnic DiversityGender and Ethnic Diversity

• Patient AdvocacyPatient Advocacy

15

Modality CommitteesModality CommitteesModality CommitteesModality Committees

• Medical OncologyMedical Oncology

• PathologyPathology• Biospecimen RepositoryBiospecimen Repository

• Radiation OncologyRadiation Oncology

• SurgerySurgery

• Medical OncologyMedical Oncology

• PathologyPathology• Biospecimen RepositoryBiospecimen Repository

• Radiation OncologyRadiation Oncology

• SurgerySurgery

16

Core Support ServicesCore Support ServicesCore Support ServicesCore Support Services

• BiostatisticsBiostatistics

• InformaticsInformatics

• Data ManagementData Management

• AuditAudit

• Operations OfficeOperations Office

• CommunicationsCommunications

• Data Monitoring CommitteeData Monitoring Committee

• BiostatisticsBiostatistics

• InformaticsInformatics

• Data ManagementData Management

• AuditAudit

• Operations OfficeOperations Office

• CommunicationsCommunications

• Data Monitoring CommitteeData Monitoring Committee

17

Who are our Mayo Clinic Who are our Mayo Clinic investigators?investigators?

Who are our Mayo Clinic Who are our Mayo Clinic investigators?investigators?

18

Mayo Clinic MD’s and PhD’s Mayo Clinic MD’s and PhD’s Participating in NCCTGParticipating in NCCTG

Mayo Clinic MD’s and PhD’s Mayo Clinic MD’s and PhD’s Participating in NCCTGParticipating in NCCTG

247

27 31

305

0

50

100

150

200

250

300

350

Rochester Jacksonville Scottsdale TOTAL

247

27 31

305

0

50

100

150

200

250

300

350

Rochester Jacksonville Scottsdale TOTAL

June 16, 2003

19

Departments/DivisionsDepartments/DivisionsRepresentedRepresented

Departments/DivisionsDepartments/DivisionsRepresentedRepresented

40

8 8

0

5

10

15

20

25

30

35

40

Rochester Jacksonville Scottsdale

40

8 8

0

5

10

15

20

25

30

35

40

Rochester Jacksonville Scottsdale

July, 2001

20

Departments/Divisions/ProgramsDepartments/Divisions/ProgramsA-MA-M

Departments/Divisions/ProgramsDepartments/Divisions/ProgramsA-MA-M

• Anesthesiology

• Area Medicine

• Biochemistry and Molecular Biology

• Cardiovascular Diseases

• Clinical Epidemiology

• Dermatology

• Endocrinology

• Gastroenterology and Hepatology

• Anesthesiology

• Area Medicine

• Biochemistry and Molecular Biology

• Cardiovascular Diseases

• Clinical Epidemiology

• Dermatology

• Endocrinology

• Gastroenterology and Hepatology

• General Internal Medicine

• Hematology

• Health Sciences Research

• Laboratory Medicine and Pathology

• Medical Genetics

• Molecular Genetics

• Molecular Medicine Program

• General Internal Medicine

• Hematology

• Health Sciences Research

• Laboratory Medicine and Pathology

• Medical Genetics

• Molecular Genetics

• Molecular Medicine Program

July, 2001

21

Departments/Divisions/ProgramsDepartments/Divisions/ProgramsN-ZN-Z

Departments/Divisions/ProgramsDepartments/Divisions/ProgramsN-ZN-Z

• Neurologic Surgery

• Neurology

• Nicotine Dependence Center

• Nuclear Medicine

• Obstetrics and Gynecology

• Oncology

• Physical Medicine and Rehabilitation

• Neurologic Surgery

• Neurology

• Nicotine Dependence Center

• Nuclear Medicine

• Obstetrics and Gynecology

• Oncology

• Physical Medicine and Rehabilitation

• Psychiatry and Psychology

• Pulmonary and Critical Care Medicine

• Radiation Oncology

• Radiology

• Surgery

• Transplant Center

• Urology

• Neurology

• Radiation Oncology

• Surgery

• Transplantation

• Psychiatry and Psychology

• Pulmonary and Critical Care Medicine

• Radiation Oncology

• Radiology

• Surgery

• Transplant Center

• Urology

• Neurology

• Radiation Oncology

• Surgery

• Transplantation

July, 2001

22

What is our productivity?What is our productivity?What is our productivity?What is our productivity?

23

Protocol ActivityProtocol ActivityCancer Treatment and ControlCancer Treatment and Control

Protocol ActivityProtocol ActivityCancer Treatment and ControlCancer Treatment and Control

• HistoricalHistorical• 384 over 25 years384 over 25 years

• Currently activeCurrently active• 50 open50 open• 235 closed with follow up taking 235 closed with follow up taking

placeplace

• Currently in developmentCurrently in development• 3737

• HistoricalHistorical• 384 over 25 years384 over 25 years

• Currently activeCurrently active• 50 open50 open• 235 closed with follow up taking 235 closed with follow up taking

placeplace

• Currently in developmentCurrently in development• 3737

June 13, 2003

24

Patient AccrualPatient AccrualCancer Treatment and ControlCancer Treatment and Control

(58,537 over 25 years)(58,537 over 25 years)

Patient AccrualPatient AccrualCancer Treatment and ControlCancer Treatment and Control

(58,537 over 25 years)(58,537 over 25 years)

3,010

4,684 4,870

0500

1,0001,5002,0002,5003,0003,5004,0004,5005,000

2000 2001 2002

3,010

4,684 4,870

0500

1,0001,5002,0002,5003,0003,5004,0004,5005,000

2000 2001 2002

June 13, 2003

25

Tissue SpecimensTissue Specimens(10,334 over 25 years)(10,334 over 25 years)

Tissue SpecimensTissue Specimens(10,334 over 25 years)(10,334 over 25 years)

755 775

938

0100200300400500600700800900

1,000

2000 2001 2002

755 775

938

0100200300400500600700800900

1,000

2000 2001 2002

June 13, 2003

26

NCCTG PublicationsNCCTG Publications2000-2002 Journals2000-2002 Journals

NCCTG PublicationsNCCTG Publications2000-2002 Journals2000-2002 Journals

• Am J Clin Oncol

• Br J Haematol

• Cancer

• Cancer Invest

• Clinical Cancer Research

• Current Oncology Reports

• Int J Gynaecol Obstet

• Int J Radiat Oncol Biol Phys

• Invest New Drugs

• J Clin Oncol

• J Neurooncol

• J Neurosurg

• Am J Clin Oncol

• Br J Haematol

• Cancer

• Cancer Invest

• Clinical Cancer Research

• Current Oncology Reports

• Int J Gynaecol Obstet

• Int J Radiat Oncol Biol Phys

• Invest New Drugs

• J Clin Oncol

• J Neurooncol

• J Neurosurg

• J Natl Cancer Inst

• JAMA

• Lancet

• Leukemia

• Lung Cancer

• Meta-Analysis

• N Engl J Med

• Oncology

• Oncol Nurs Forum

• Semin Oncol

• Stat Med

• Support Care Cancer

• J Natl Cancer Inst

• JAMA

• Lancet

• Leukemia

• Lung Cancer

• Meta-Analysis

• N Engl J Med

• Oncology

• Oncol Nurs Forum

• Semin Oncol

• Stat Med

• Support Care Cancer

27

What are the education What are the education components?components?

What are the education What are the education components?components?

28

Target AudiencesTarget AudiencesTarget AudiencesTarget Audiences

• PhysiciansPhysicians

• NursesNurses

• CRA’sCRA’s

• Patient AdvocatesPatient Advocates

• PhysiciansPhysicians

• NursesNurses

• CRA’sCRA’s

• Patient AdvocatesPatient Advocates

29

Educational SymposiaEducational SymposiaTopicsTopics

Educational SymposiaEducational SymposiaTopicsTopics

• New Directions in Oncologic ImagingNew Directions in Oncologic Imaging

• Colorectal Cancer: Revising Colorectal Cancer: Revising Standards/Evolving TreatmentsStandards/Evolving Treatments

• Breast Cancer Management: Current Status Breast Cancer Management: Current Status and Future Research Directionsand Future Research Directions

• Molecular Markers: Current Oncologic Molecular Markers: Current Oncologic ApplicationApplication

• Melanoma in the 21st CenturyMelanoma in the 21st Century

• AJCC Staging of Breast/Colon CancerAJCC Staging of Breast/Colon Cancer

• New Directions in Oncologic ImagingNew Directions in Oncologic Imaging

• Colorectal Cancer: Revising Colorectal Cancer: Revising Standards/Evolving TreatmentsStandards/Evolving Treatments

• Breast Cancer Management: Current Status Breast Cancer Management: Current Status and Future Research Directionsand Future Research Directions

• Molecular Markers: Current Oncologic Molecular Markers: Current Oncologic ApplicationApplication

• Melanoma in the 21st CenturyMelanoma in the 21st Century

• AJCC Staging of Breast/Colon CancerAJCC Staging of Breast/Colon Cancer

June, 2003

30

Education Symposia Education Symposia Visiting LecturersVisiting Lecturers

Education Symposia Education Symposia Visiting LecturersVisiting Lecturers

• NR DunnickNR Dunnick University of MichiganUniversity of Michigan

• RJ MayerRJ Mayer Dana FarberDana Farber

• NJ MeropolNJ Meropol Fox ChaseFox Chase

• AP VenookAP Venook University of CaliforniaUniversity of California

• GN Hortobagyi GN Hortobagyi MD AndersonMD Anderson

• HL McLeodHL McLeod Washington UniversityWashington University

• CM BalchCM Balch ASCOASCO

• H FreemanH Freeman NCI; Harlem HospitalNCI; Harlem Hospital

• NR DunnickNR Dunnick University of MichiganUniversity of Michigan

• RJ MayerRJ Mayer Dana FarberDana Farber

• NJ MeropolNJ Meropol Fox ChaseFox Chase

• AP VenookAP Venook University of CaliforniaUniversity of California

• GN Hortobagyi GN Hortobagyi MD AndersonMD Anderson

• HL McLeodHL McLeod Washington UniversityWashington University

• CM BalchCM Balch ASCOASCO

• H FreemanH Freeman NCI; Harlem HospitalNCI; Harlem Hospital

31

Nurses and CRAsNurses and CRAsNurses and CRAsNurses and CRAs

• Semi-annual symposiaSemi-annual symposia• Specific Disease FocusSpecific Disease Focus• CAMCAM• Special PopulationsSpecial Populations

• CRA Training WorkshopsCRA Training Workshops• Skills FairSkills Fair• SOCRA certificationSOCRA certification• Double enrollmentDouble enrollment

• Semi-annual symposiaSemi-annual symposia• Specific Disease FocusSpecific Disease Focus• CAMCAM• Special PopulationsSpecial Populations

• CRA Training WorkshopsCRA Training Workshops• Skills FairSkills Fair• SOCRA certificationSOCRA certification• Double enrollmentDouble enrollment

32

Patient AdvocatesPatient AdvocatesPatient AdvocatesPatient Advocates

• Coalition modulesCoalition modules• Clinical trial components and conductClinical trial components and conduct

• Semi-annual meetingsSemi-annual meetings• Dinner speakers/guestsDinner speakers/guests• Committee businessCommittee business• Research committee participationResearch committee participation

• Spring Symposium 2003Spring Symposium 2003

• Coalition modulesCoalition modules• Clinical trial components and conductClinical trial components and conduct

• Semi-annual meetingsSemi-annual meetings• Dinner speakers/guestsDinner speakers/guests• Committee businessCommittee business• Research committee participationResearch committee participation

• Spring Symposium 2003Spring Symposium 2003

33

VisionVisionVisionVision

• GrowthGrowth

• Financial securityFinancial security

• CollaborationCollaboration

• GrowthGrowth

• Financial securityFinancial security

• CollaborationCollaboration

34

GrowthGrowthGrowthGrowth

• AccrualAccrual

• Scientific ProgramsScientific Programs• BreadthBreadth• DepthDepth• New ProgramsNew Programs

• MelanomaMelanoma

• MembershipMembership

• AccrualAccrual

• Scientific ProgramsScientific Programs• BreadthBreadth• DepthDepth• New ProgramsNew Programs

• MelanomaMelanoma

• MembershipMembership

35

Financial SecurityFinancial SecurityFinancial SecurityFinancial Security

• Prudent managementPrudent management

• Ancillary grants/contractsAncillary grants/contracts

• Industry partnershipIndustry partnership

• Prudent managementPrudent management

• Ancillary grants/contractsAncillary grants/contracts

• Industry partnershipIndustry partnership

36

CollaborationCollaborationCollaborationCollaboration

• Mayo Clinic Cancer CenterMayo Clinic Cancer Center

• Cooperative Groups/CoalitionCooperative Groups/Coalition

• Academic institutionsAcademic institutions

• IndustryIndustry

• Mayo Clinic Cancer CenterMayo Clinic Cancer Center

• Cooperative Groups/CoalitionCooperative Groups/Coalition

• Academic institutionsAcademic institutions

• IndustryIndustry

37

PurposePurposePurposePurpose