ncccp informatics ken buetow, ph.d. leslie derr, ph.d. john speakman nci center for biomedical...

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NCCCP Informatics Ken Buetow, Ph.D. Leslie Derr, Ph.D. John Speakman NCI Center for Biomedical Informatics and Information Technology June 25, 2007

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Page 1: NCCCP Informatics Ken Buetow, Ph.D. Leslie Derr, Ph.D. John Speakman NCI Center for Biomedical Informatics and Information Technology June 25, 2007

NCCCP InformaticsKen Buetow, Ph.D.Leslie Derr, Ph.D.John Speakman

NCI Center for Biomedical Informatics and Information Technology

June 25, 2007

Page 2: NCCCP Informatics Ken Buetow, Ph.D. Leslie Derr, Ph.D. John Speakman NCI Center for Biomedical Informatics and Information Technology June 25, 2007

caBIG™ MissionMission: A virtual web of interconnected data, individuals, and organizations redefines how research is conducted, care is provided, and patients/participants interact with the biomedical research enterprise

Next generation World WideWeb of biomedical research

Page 3: NCCCP Informatics Ken Buetow, Ph.D. Leslie Derr, Ph.D. John Speakman NCI Center for Biomedical Informatics and Information Technology June 25, 2007

caBIG™ Framework

– Connect the cancer research community through a shareable, interoperable infrastructure

– Deploy and Extend standard rules and a common language to more easily share information

– Build or adapt tools for collecting, analyzing, integrating and disseminating information associated with cancer research and care

Page 4: NCCCP Informatics Ken Buetow, Ph.D. Leslie Derr, Ph.D. John Speakman NCI Center for Biomedical Informatics and Information Technology June 25, 2007

caBIG™ Connects the Cancer Community: Researchers, Clinicians, Patients

AlabamaBirmingham: UAB Comprehensive Cancer Center ArizonaPhoenix: Translational Genomics Research Institute Tucson: University of Arizona CaliforniaBerkeley: University of California Lawrence Berkeley National Laboratory University of California at Berkeley Los Angeles: AECOM California Institute of Technology University of Southern California Information Sciences Institute University of California at Irvine The Chao Family Comprehensive Cancer Center La Jolla: The Burnham Institute Sacramento: University of California Davis Cancer Center San Diego: SAIC San Francisco: University of California San Francisco Comprehensive Cancer Center ColoradoAurora: University of Colorado Cancer Center District of ColumbiaDepartment of Veterans Affairs Lombardi Cancer Research Center - Georgetown University Medical Center FloridaTampa: H. Lee Moffitt Cancer Center at the University of South Florida HawaiiManoa: Cancer Research Center of Hawaii IllinoisArgonne: Argonne National Laboratory Chicago: Robert H. Lurie Comprehensive Cancer Center of Northwestern University University of Chicago Cancer Research Center Urbana-Champaign: University of Illinois at Urbana-Champaign IndianaIndianapolis:Indiana University Cancer Center Regenstrief Institute, Inc.

IowaIowa City: Holden Comprehensive Canter Center at the University of Iowa LouisianaNew Orleans: Tulane University School of Medicine MaineBar Harbor: The Jackson Laboratory MarylandBaltimore: The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University Bethesda: Consumer Advocates in Research and Related Activities (CARRA) NCI Cancer Therapy Evaluation Program NCI Center for BioinformaticsNCI Center for Cancer Research NCI Center for Strategic Dissemination NCI Division of Cancer Control and Population Sciences NCI Division of Cancer Epidemiology and Genetics NCI Division of Cancer Prevention NCI Division of Cancer Treatment and Diagnosis Terrapin Systems Rockville: Capital Technology Information Services Emmes Corporation Information Management Services, Inc. MassachusettsCambridge: Akaza Research Massachusetts Institute of Technology Somerville:Panther Informatics MichiganAnn Arbor: Internet2 University of Michigan Comprehensive Cancer Center Detroit: Meyer L. Prentis/Karmanos Comprehensive Cancer Center MinnesotaMinneapolis:University of Minnesota Cancer Center Rochester:Mayo Clinic Cancer Center NebraskaOmaha:University of Nebraska Medical Center/Eppley Cancer Center New HampshireLebanon:Dartmouth College Dartmouth-Hitchcock Medical Center

New YorkBuffalo: Roswell Park Cancer Institute Bronx:Albert Einstein Cancer Center Cold Spring Harbor:Cold Spring Harbor Laboratory New York:Herbert Irving Comprehensive Cancer Center Columbia University Memorial Sloan-Kettering Cancer Center New York University Medical Center White Plains: IBM North CarolinaChapel Hill: University of North Carolina Lineberger Comprehensive Cancer Center Raleigh-Durham: Alpha-Gamma Technologies, Inc. Constella Health SciencesDuke Comprehensive Cancer Center OhioCleveland: Case Comprehensive Cancer Center Columbus: Ohio State University Comprehensive Cancer Center OregonPortland: Oregon Health & Science University PennsylvaniaPhiladelphia: Drexel University Fox Chase Cancer Center Kimmel Cancer Center at Thomas Jefferson University Abramson Cancer Center of the University of Pennsylvania Pittsburgh: University of Pittsburgh Cancer Institute TennesseeMemphis: St. Jude’s Children’s Research Hospital TexasAustin: 9 Star Research Houston: M.D. Anderson Cancer Center VirginiaFairfax: SRA International Reston: Scenpro WashingtonSeattle: DataWorks Development, Inc. Fred Hutchinson Cancer Research Center InternationalParis, France: Sanofi Aventis

Page 5: NCCCP Informatics Ken Buetow, Ph.D. Leslie Derr, Ph.D. John Speakman NCI Center for Biomedical Informatics and Information Technology June 25, 2007

Molecular Medicine as a Complex Continuum

Clinical Research

PathologyMolecular Biology

Imaging

Molecular Medicine

Page 6: NCCCP Informatics Ken Buetow, Ph.D. Leslie Derr, Ph.D. John Speakman NCI Center for Biomedical Informatics and Information Technology June 25, 2007

Assembling the Cancer Community

ArchitectureDevelops architectural standards and architecture

necessary for other workspaces.

Vocabularies & Common Data Elements

Evaluates, develops, and integrates systems for vocabulary and ontology content, standards, and

software systems for content delivery.

In vivo Imaging

Tissue Banks andPathology Tools

Provides for the integration, development, and implementation of tissue and pathology tools.

Integrative Cancer ResearchProvides tools and systems to enable integration and sharing of information.

Clinical TrialsManagement Systems

Addresses the need for consistent,open and comprehensive tools for clinical trials management.

Provides for the sharing and analysis of in vivo imaging data.

Strategic Planning

Documentation and Training

Data Sharing and Intellectual Capital

Assists in identifying strategic priorities for the development and evolution of the caBIG™ effort.

Provides training in the use of caBIG™ resources including on-line tutorials, workshops, documentation

Develops policies and guidelines for sharing of data, applications and infrastructure

Page 7: NCCCP Informatics Ken Buetow, Ph.D. Leslie Derr, Ph.D. John Speakman NCI Center for Biomedical Informatics and Information Technology June 25, 2007

Managed through electronic interfaces and

data about data

focus on boundaries, interfaces, how things fit together, not on the internal details

caBIG Strategy

• Modules that address specific needs

• Use of internationaldata standards

• Connect throughdefined electronic interfaces

Page 8: NCCCP Informatics Ken Buetow, Ph.D. Leslie Derr, Ph.D. John Speakman NCI Center for Biomedical Informatics and Information Technology June 25, 2007

Utilizing caBIG™ in NCCCP

Organizations leverage caBIG™ through the following:

– Access the capabilities of caBIG™, including software, data standards, training, documentation, and support

– Apply caBIG™ to achieve bench-to-bedside-to-bench molecular medicine

– Apply caBIG™ beyond cancer to other diseases– Build on/contribute to caBIG™ policies and

procedures

Page 9: NCCCP Informatics Ken Buetow, Ph.D. Leslie Derr, Ph.D. John Speakman NCI Center for Biomedical Informatics and Information Technology June 25, 2007

Informatics Strategy

• Year 1: Plan– Assess informatics capabilites/challenges of each site,

stratify sites into tiers, determine strategy• Year 2: Do

– Execute according to plan (develop detailed plan for implementing caBIG™ infrastructure)

• Year 3: Assess– Evaluate execution according to plan– Document lessons learned

(barriers to implementation, successful strategies,future opportunities)

Page 10: NCCCP Informatics Ken Buetow, Ph.D. Leslie Derr, Ph.D. John Speakman NCI Center for Biomedical Informatics and Information Technology June 25, 2007

Stratification of sites: Tier 1

Year 1: Plan, Year 2: Do, Year 3: AssessBaseline

“Tier 1”

sites

• Baseline plus: Collaboratively identify and deploy caBIG™ in a manner that would add value to the site, either– using NCI as an application service provider, or– installing infrastructure locally, or– adapting local systems to share data in a caBIG™ compliant

manner

Page 11: NCCCP Informatics Ken Buetow, Ph.D. Leslie Derr, Ph.D. John Speakman NCI Center for Biomedical Informatics and Information Technology June 25, 2007

Stratification of sites: Tier 2

Year 1: Plan, Year 2: Do, Year 3: AssessBaseline

“Tier 1”

sites

• Baseline plus: Collaboratively identify and deploy caBIG™ in a manner that adds value to the site, either– using NCI as an application service provider, or– installing infrastructure locally, or– adapting local systems to share data in a caBIG™ compliant

manner

“Tier 2”

sites

• Tier 1 plus: Use local electronic medical record infrastructure, either pre-existing or open source, to prototype a virtual national clinical data warehouse

Page 12: NCCCP Informatics Ken Buetow, Ph.D. Leslie Derr, Ph.D. John Speakman NCI Center for Biomedical Informatics and Information Technology June 25, 2007

Informatics Breakout Tomorrow

• Introductions• Detailed overview of the caBIG™ program• Informal presentations from sites

– Very brief– No slides needed– Discussion of sites’ IT and informatics

strengths and needs• Planning our next steps

Page 13: NCCCP Informatics Ken Buetow, Ph.D. Leslie Derr, Ph.D. John Speakman NCI Center for Biomedical Informatics and Information Technology June 25, 2007

Thank you

Q & A