The National Biomedical Imaging Archive (NBIA)

In Action: An Introduction

for Users

A Tool Demonstration from caBIG®

Presented by:

Eliot Siegel, MDMaryland VA Healthcare System

University of Maryland

Agenda and Goal

• caBIG® Overview and Introduction to NBIA• NBIA Functionality• Resources and Next Steps

• The goal of this demo is to introduce you to the capabilities and benefits of a tool that is available for adoption from caBIG®. You can also adapt your existing tool to become caBIG®-compatible, or set up your tool to interface with this one.

caBIG® Overview

caBIG® is an information network enabling all constituencies in the cancer community – researchers, clinicians, patients – to share data and knowledge to accelerate the discovery of new diagnostics and therapeutics, and improve patient outcomes.

caBIG® Vision• Adapt or Build tools for collecting, analyzing, integrating and

disseminating information associated with cancer research and care

• Connect the cancer research community through a shareable, interoperable infrastructure

• Deploy and extend standard rules and a common language to more easily share information

NBIA Introduction

National Biomedical Imaging Archive (NBIA) is a searchable, national repository supported by NCI CBIIT that integrates in vivo cancer images with clinical and genomic data NBIA provides the cancer research community, industry, and academia with public access to DICOM images, image markup, annotations, and rich metadata.

Using NBIA: Who and Why?

• Target Users:

Researchers who use images as part of their research. This could include, but is not limited to:• Radiologists

• Nuclear Medicine Specialists

• Radiation Oncologists

• Clinical Trial Managers

• Core Functions:

The current release of the NBIA allows end users (with the proper security clearance) to:• Download imaging studies, series, or individual images after specifying

the type of images that are desired

• Resume an interrupted download

• Save a recurring query, as well as measurements made on selected images

How NBIA Fits Into A Research WorkflowExample: Osteoarthritis Initiative

Demonstration of National

Biomedical Imaging Archive

A Quick Preview: Key Functions and Benefits of NBIA

Key Functionality

•Single Point of Access to Images to Support:

• Development and validation of analytical software for lesion detection and classification

• Accelerated diagnostic imaging decision making

• Quantitative imaging assessment of drug response

•Web-based Visualization and Annotation Capabilities:

• NCI Instance: Cedara I-Response client software

• Deployment Package: One’s one visualization tool can be “plugged in”

• Immediate on-screen visualization of DICOM images integrated with NBIA query results

• Persistence of annotations from client to NBIA archive

• Illustration of virtual central read functionality

Some Adopters of NBIA:

Baltimore VA Medical Center

Features of the new NBIA v4.2

• Access public data without an account

• Direct external application access to NBIA’s data basket

• View image thumbnails or use Cine Mode from data basket

• Visualize images using I-Response from data basket

• Display study time in new format, Baseline + n month(s)

• Upgraded Clinical Trial Processor (image electronic submission/de-identification tool) with faster submission performance

• WG S142 baseline anonymization script

• Added analytical operations in Grid service

• Allows external cancer centers to install NBIA with their own logo

• Improved upgrade process for external cancer centers

Features Under Development

• Visualization tool for the deployment version of the NBIA • The I-Response visualization and annotation tool (seen in the

demo) is only available on the NCI instance of the NBIA. • The Imaging Workspace has set as one of its highest priorities

for the 2010 to provide a general purpose visualization tool.• This tool will also provide annotation capability in AIM (the

caBIG® Annotation Imaging Markup Standard format for annotation and markup).

• Generation of Annotations• The NBIA team is in the process converting its largest

collection, the RIDER/LIDC annotations into AIM format.• The general purpose visualization tool (or workstation) will

support AIM and will be “plug-in-able” to the deployment and NCI versions of the NBIA.

Getting Started: A Glance at the Technology

• Tool Platform: Web Application - Remote application with data uploads / downloads through the web interface

• Key Prerequisites: (Only for local installation)

1. System requirements: Minimal requirements include a Windows or Linux operating system with sufficient hard drive capacity and 3GB of RAM. A typical workstation from a hardware vendor will be minimally sufficient.

2. IT Support: Skill sets needed: Database administrators with specific experience in installing and supporting web based applications.

• End User Readiness: Staff experienced in extracting images from PACS machines, and the ability to package and submit them to the field center.

Resources and Next Steps

Two Pathways: Adopt or Adapt

• Interested organizations are not required to adopt this tool to connect with caBIG®

• There are other ways to share data and use common data elements and controlled vocabularies by adapting current or non-caBIG® applications

Adopting NBIA Release Timeline and Future Plans

Release Information• Latest Release: NBIA v4.2, May 2008

This release was a back end database migration from Oracle to MySQL

Development Schedule• Currently planning for a new release Spring 2010 – NBIA v4.3• Planned enhancements include AIM Compatibility and Plug In capability for the

caBIG Radiology Workstation*• NCI CBIIT plans to provide ongoing, production level support.

Support Available• Technical support is available via NCICB Application Support • Telephone: (301) 451-4384 / (888) 478-4423

Email: ncicb@pop.nci.nih.gov

* These and other proposed enhancements for a Spring 2010 release are currently being prioritized by the caBIG Imaging program leadership.

The Next Step: Accessing Online Resources for (Tool Name)

NBIA Online http://nbia.nci.nih.gov/

Tool Landing Page https://cabig.nci.nih.gov/tools/NBIA

Access to Demo Passwords and Logins

ncicb@pop.nci.nih.gov

Software DevelopmentProject Site

https://gforge.nci.nih.gov/projects/nbia/

LISTSERV Signup ncia_announcements@list.nih.gov

caBIG Imaging Community

cabig_img_community@list.nih.gov

Domain Support mulhern_paul@bah.com

NCI Center forBioinformaticsApplications Support

ncicb@pop.nci.nih.gov

Thanks for Attending!

• We’d like to know what you think!

• Did you get useful information from this presentation?

• What additional information or future presentation topics would you like to see?

• Send your feedback to caBIGconnect@cancer.gov