nature genetics: doi:10.1038/ng · heat map depicting the virulence profiles, o antigens and...

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Supplementary Figure 1

Heat map depicting the virulence profiles, O antigens and incompatibility groups of isolates in L1–L5.

Presence of colonization factors, toxins, O antigens and plasmid incompatibility groups (FII, FIIS, FIB, FII-s, FrepB, HI1, I1, K and X1) within lineages L1–L5. UG designation is used for isolates. An asterisk indicates isolates ± CS21; n.i., not identified.

Nature Genetics: doi:10.1038/ng.3145

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Heat map depicting the virulence profiles, O antigens and incompatibility groups of isolates in L6–L10.

Presence of colonization factors, toxins, O antigens and plasmid incompatibility groups (FII, FIIS, FIB, FII-s, FrepB, HI1, I1, K and X1) within lineages L6–L10. UG designation is used for isolates. An asterisk indicates isolates ± CS21; n.i., not identified.


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Midpoint-rooted phylogenetic tree displaying the colonization factor profile or each lineage.

The phylogenetic tree is SNP based with probable recombination events removed, colored according to lineage and displaying the colonization factor profile for each lineage. Lineages L1–L21 and reference strains are indicated.


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Midpoint-rooted phylogenetic tree showing the country of isolation for each isolate.

The phylogenetic tree is SNP based with probable recombination events removed, depicting the country of isolation for each isolate as colored symbols on branch tips. Reference strains are indicated.


Supplementary Table 1 List of E. coli reference strains included in the phylogenetic trees. Reference strains and their respective accession numbers. Reference Accession no. E. coli commensal HS CP000802.1 E. coli str. K-12 substr. MG1655 U00096.2 E. coli str. K12 substr. W3110 AP009048 ETEC B7A AAJT02000001.1 ETEC H10407 NC_017633.1 ETEC E24377A NC_009801.1 EAEC 101-1 AAMK02000001.1 EHEC O157:H7 EDL933 AE005174.2 EHEC O157:H7 str. Sakai BA000007.2 EIEC 53638 AAKB02000001.1 EPEC B171 AAJX02000001.1 EPEC E22 AAJV02000001.1 EPEC E110019 AAJW02000001.1 Shigella flexneri M90T CM001474.1 Shigella flexneri 8401 CP000266 Shigella sonnei 53G HE616528.1 Shigella sonnei Ss046 CP000038 UPEC 536 CP000247.1 UPEC F11 AAJU02000001.1 UPEC CFT073 AE014075.1 UPEC UTI89 CP000243.1


Supplementary Table 2 List of the 362 ETEC isolates included in the study. Isolates used in the study ordered after lineage, L1-L5 are highlighted. Includes geographical, temporal data and information regarding the subject the samples were isolated from. Also includes virulence profile (colonization factors and toxins), phylo-group, MLST type, O antigen and incompatibility group.

Isolates (UG designation)

Phylo-group

MLST type1 Lineage O antigen1-4

Incompatibility group1

Toxin profile CF profile5-6

Year of isolation Origin (Country) Subject

Age of subject D/AS/ENV7

E8 A 2353 L1 O6 FII, FIB, I1 LT+STh CS1+CS3 1980 Bangladesh Indigenous All ages

E54 A 2353 L1 O6 FII, FIB, I1 LT+STh CS1+CS3+CS21 1980 Bangladesh Indigenous All ages D

E263 A 4 L1 O6 FII, FIB, FrepB,

I1 LT+ST CS1+CS21 1987 Japan Traveller Adult D

E471 A 4 L1 O6 FII, FIB, I1 LT+STh CS1+CS3+CS21 2000 Guatemala Traveller Adult D/AS

E517 A 2353 L1 O6 FII, FIB, I1 LT+STh CS1+CS3 2000 Mexico Traveller Adult D/AS

E632 A 4 L1 O6 FII, FIB, I1 LT+STh CS1+CS3+CS21 2000 Guatemala Traveller Adult AS

E812 A 2353 L1 O6 FII, FIIY, FIB,

FrepB, I1 STh CS1+CS3+CS21 2002 Guatemala Traveller Adult D

E863 A 2353 L1 O6 FIB, I1 LT+STh CS1+CS3+CS21 2003 Guatemala Indigenous Child <5 yrs D


FrepB, I1 LT+STh CS1+CS3+CS21 2003 Guatemala Indigenous Child <5 yrs D


FrepB, I1 LT+STh CS1+CS3+CS21 1997 Egypt Soldier Adult D

E953 A 2353 L1 O6 FII, FIIY, FIB, FrepB, I1, K LT+STh CS1+CS3+CS21 1997 Egypt Soldier Adult D


FrepB, I1 LT+STh CS1+CS3+CS21 1997 Egypt Soldier Adult D


FrepB, I1 LT+STh CS1+CS3+CS21 2000 Egypt Indigenous Child <5 yrs D/AS


FrepB, I1 LT+STh CS1+CS3+CS21 1996 Nepal Traveller Adult unknown


FrepB, I1 LT+STh CS1+CS3+CS21 1997 Morocco Traveller Adult D


FrepB, I1 LT+STh CS1+CS3+CS21 1989 Argentina Indigenous Child <5 yrs D

E1620 A 6 L1 O6 FIB, I1, K LT+STh CS1+CS3+CS21 1989 Argentina Indigenous Child <5 yrs D


FrepB, I1 LT+STh CS1+CS3+CS21 1990 Indonesia Indigenous Child <5 yrs D



FrepB, I1 LT+STp CS1+CS3+CS21 1990 Indonesia Traveller Adult D


FrepB, I1 LT+STh CS1+CS3+CS21 2002 Bangladesh Indigenous All ages D


FrepB, I1 LT+STh CS1+CS3+CS21 2007 Bangladesh Indigenous Child <5 yrs AS


FrepB, I1 LT+STh CS1+CS3+CS21 2007 Bolivia Indigenous Child <5 yrs D

E2386 A 4 L1 O6 FII, FIB, FrepB LT+STh CS1+CS3+CS21 2007 Bolivia Indigenous Child <5 yrs D

E66 A 4 L2 O6 FII, FIIS, FIIY,

FIB, FrepB LT+STh CS2+CS3+CS21 1988 Bangladesh Indigenous All ages D


FIB, FrepB LT+STh CS2+CS3+CS21 1988 Bangladesh Indigenous Child <5 yrs D

E71 A 4 L2 O6 FIB, X1 LT+STh CS2+CS3+CS21 1988 Bangladesh Indigenous Child <5 yrs D

E87 A 4 L2 O6 FII, FIIS, FIIY, FIB, FrepB, X1 LT+STh CS2+CS3+CS21 1988 Bangladesh Indigenous Child <5 yrs D

E99 A 4 L2 O6 FII, FIIS, FIIY, FIB, FrepB, X1 LT+STh CS2+CS21 1988 Bangladesh Indigenous Child <5 yrs D


FIB, FrepB LT+STh CS2+CS3+CS21 1983 Japan Traveller Adult D

E272 A 4 L2 O6 FII, FrepB LT+STh CS2+CS3 1987 Japan Traveller Adult D

E822 A 3853 L2 O6 FII, FIB LT+STh CS2+CS3+CS21 2002 Guatemala Traveller Adult D

E903 A 4 L2 O6 FII, FIIS, FIIY, FIB, FrepB, X1 LT+STh CS2+CS3+CS21 2003 Guatemala Indigenous Child <5 yrs D


FrepB LT+STh CS2+CS3 1999 Egypt Indigenous Child <5 yrs D

E1624 A 4 L2 O6 FII, FIIS, FIIY, FIB, FrepB, Y LT+STh CS2+CS3+CS21 1990 Indonesia Traveller Adult D

E1649 A 4 L2 O6 FII, FIIS, FIIY, FIB, FrepB, Y LT+STh CS2+CS3+CS21 1997 Indonesia

Traveller/Soldier Adult D

E1667 A 4 L2 O6 FII, FIIS, FIIY, FIB, FrepB, Y LT+STh CS2+CS3+CS21 1997 Indonesia



FIB, FrepB LT+STh CS2+CS3+CS21 2007 Bangladesh Indigenous Child <5 yrs AS

E36 B1 173 L3 O78 FII, FIB, FrepB LT+STh CFA/I+CS21 1980 Bangladesh Indigenous All ages D

E45 B1 173 L3 O78 FII, FIB, FII-s,

FrepB LT+STh CFA/I+CS21 1980 Bangladesh Indigenous All ages D

E74 B1 173 L3 O78 FII, FIB, FrepB LT+ST CS21 1988 Bangladesh Indigenous All ages D

E141 B1 n.i. L3 O114 FII, FIIS, FrepB, I1 LT CS7 1989 Burma Indigenous unknown D


E658 B1 173 L3 O78 FIB, I1 LT CFA/I+CS21 2001 Guatemala Traveller Adult AS

E810 B1 6 L3 O78 FII, FIB, FrepB LT+STh CFA/I+CS21 2002 Guatemala Traveller Adult D

E858 B1 6 L3 O78 FII, FIIY, FIB,

FrepB LT+STh CFA/I+CS21 2003 Guatemala Indigenous Child <5 yrs D

E917 B1 173 L3 O78 FIB STh CFA/I+CS21 2003 Guatemala Indigenous Child <5 yrs D

E1009 B1 n.i. L3 O114 FII, FrepB, I1

x2, K LT CS7 1999 Egypt Indigenous Child <5 yrs D

E1541 B1 173 L3 O78 FII, FIB, FrepB STh CFA/I+CS21 1989 Argentina Indigenous Child <5 yrs D

E1587 B1 173 L3 O78 FII, FIB, FrepB STh CFA/I+CS21 1989 Argentina Indigenous Child <5 yrs D

E1592 B1 173 L3 O128 FII, FIIS, FIIY, FII-s, FrepB, I1 LT CS7 1989 Argentina Indigenous Child <5 yrs D

E1666 B1 173 L3 O126 FII, FIB, FrepB,

I1 STh CFA/I+CS21 1990 Indonesia Indigenous Child <5 yrs D

E1716 B1 173 L3 O78 FIB, FrepB STh CFA/I 2001 Bangladesh Indigenous All ages D


I1 STh CFA/I+CS21 2007 Bangladesh Indigenous Child <5 yrs AS

E1939 B1 n.i. L3 O114 FII, FrepB, I1 LT CS7 2007 Bangladesh Indigenous Child <5 yrs D


I1, X4 STh CFA/I+CS21 2007 Bangladesh Indigenous Child <5 yrs D


K LT+STh CFA/I+CS21 2007 Bangladesh ENV ENV ENV

E2131 B1 173 L3 O128 FII, FIB, FrepB ST CS21 2007 Bangladesh Indigenous Child <5 yrs D

E2347 B1 173 L3 O78 FII, FrepB, I1 LT CF NEG 2007 Bolivia Indigenous Child <5 yrs D

E2980 B1 n.i. L3 O114 FII, FrepB, I1 LT CS7 2010 Bangladesh unknown unknown unknown

E5086 B1 173 L3 O126 FII, FIB, FrepB STh CFA/I+CS21 2011 Bangladesh Indigenous Adult D

E135 A 1312 L4 O25 FII, FrepB LT CS6+CS8 1989 unknown Indigenous unknown D

E340 A 1312 L4 O25 FII, FIB, FrepB STh CS21 1998 Mexico Traveller Adult D/AS


I1 STh CS21 1998 Mexico Traveller Adult D/AS

E924 A 1312 L4 O25 FII, FIB, FrepB STh CS21 2003 Guatemala Indigenous Child <5 yrs D

E1114 A 1312 L4 O25 FII, FrepB LT CS6+CS8 2001 Kenya Traveller/S

oldier Adult D


oldier Adult D


oldier Adult D



oldier Adult D


oldier Adult D

E1119 A 1312 L4 O25

FII, FIIS, FIIY, FIB, FII-s, FrepB, P LT CS6+CS21 2001 Kenya


E1120 A 1312 L4 O25



E1121 A 1312 L4 O25



E1122 A 1312 L4 O25

FII, FIIS, FIIY, FIB, FII-s, FrepB, P LT CS6 2001 Kenya


E1362 A 1312 L4 O25 FII, FIB, FrepB STh CS21 1996 Egypt Traveller Adult D

E1363 A 1312 L4 n.i. FII, FIB, FrepB STh CS21 1996 Egypt Traveller Adult D

E1365 A 1312 L4 O25 FII, FIB, FrepB STh CS21 1996 Egypt Traveller Adult D

E1441 A 1312 L4 O25 FII, FIB, FII-s,

FrepB, P LT CS6+CS21 1997 Kenya Traveller Adult D

E1442 A 1312 L4 O25 FII, FIB, FII-s,

FrepB, P LT CS6+CS21 1997 Kenya Traveller Adult D

E1516 A 1312 L4 O25 FII, FrepB, P LT CS6 2003 Guinea Bissau Indigenous Child <5 yrs AS

E1628 A 1312 L4 O25 FII, FIB, FrepB LT CS6+CS21 1990 Indonesia Indigenous Child <5 yrs D


K STh CS6 2002 Bangladesh Indigenous All ages D

E4092 A 1312 L4 O25 FII, FrepB LT CS6+CS8 2005 Israel Soldier Adult D

E1429tiny A 1312 L4 O25 FII, FIB, FrepB LT CS6+CS21 1997 Venezuela unknown unknown unknown

E21 B1 443 L5 O115 FII, FIIY, FrepB STh CS5+CS6 1980 Bangladesh Indigenous All ages D

E88 B1 443 L5 O167 FII, FIIY, FrepB LT+STh CS5+CS6 1988 Bangladesh Indigenous Child <5 yrs D

E110 B1 443 L5 O167 FII, FIIY, FrepB STh CS5+CS6 1985 Bangladesh Traveller Adult D

E157 B1 205 L5 O174 FII, FIIS, FIB,

FrepB, I1 LT CS6 1983 Japan Traveller Adult D

E655 B1 443 L5 O115 FII, FIIY, FII-s,

FrepB STh CS5+CS6 2000 Guatemala Traveller Adult D

E865 B1 443 L5 O115 FII, FrepB STh CS5+CS6 2003 Guatemala Indigenous Child <5 yrs D


E867 B1 443 L5 O115 FII, FIIS, FIIY,

FrepB STh CS5+CS6 2003 Guatemala Indigenous Child <5 yrs D

E877 B1 443 L5 O115 FII, FrepB STh CS5+CS6 2003 Guatemala Indigenous Child <5 yrs D

E900 B1 443 L5 O167 FII, FrepB LT CS17 2003 Guatemala Indigenous Child <5 yrs D

E916 B1 443 L5 O115 FII, FIIY, FII-s,

FrepB STh CS5+CS6 2003 Guatemala Indigenous Child <5 yrs D

E1003 B1 443 L5 O39 FII, FIIY,

FrepB, X4 LT+STh CS5+CS6 1999 Egypt Indigenous Child <5 yrs D

E1034 B1 443 L5 O39 n.i. LT+STh CS5+CS6 1999 Egypt Indigenous Child <5 yrs D


FrepB, X1 LT+STh CS5+CS6 2000 Egypt Indigenous Child <5 yrs D/AS

E1111 B1 443 L5 O167 FII, FrepB, X1 LT+STh CS5+CS6 2000 Egypt Indigenous Child <5 yrs D/AS

E1298 B1 443 L5 O167 n.i. LT+STh CS5+CS6 2001 Egypt Indigenous Child <5 yrs D

E1625 B1 205 L5 O174 FII, FIIS, FIB,

FrepB LT CS6 1990 Indonesia Indigenous Child <5 yrs D

E1635 B1 443 L5 O167 FII LT CS17 1997 Indonesia Traveller/S

oldier Adult D

E1646 B1 443 L5 O115 FII, FIIY, FrepB STh CS5+CS6 1990 Indonesia Traveller Adult D

E1724 B1 443 L5 O115 FIIY LT+STh CS5+CS6 2001 Bangladesh Indigenous All ages D

E1741 B1 n.i. L5 O167 FII LT+ST CS17 2002 Bangladesh Indigenous All ages D

E1750 B1 443 L5 O115 FIIY LT+STh CS5+CS6 2002 Bangladesh Indigenous All ages D

E1760 B1 443 L5 O115 FII, FIIY, FrepB LT+STh CS5+CS6 2002 Bangladesh Indigenous All ages D


FrepB LT+STh CS5+CS6 2005 Bangladesh Indigenous Adult unknown

E1918 B1 443 L5 O115 FIIY, FII-s LT+STh CS5+CS6 2007 Bangladesh Indigenous Child <5 yrs D

E1994 B1 443 L5 O167 FII LT CS17 2007 Bangladesh Indigenous Child <5 yrs D/AS

E2092 B1 443 L5 O115 FIIY LT+STh CS5+CS6 2007 Bangladesh Indigenous Child <5 yrs D

E2118 B1 443 L5 O167 FII LT CS17 2007 Bangladesh Indigenous Child <5 yrs AS

E2339 B1 443 L5 O167 FII, FIIY,

FrepB, X1 LT+STh CS5+CS6 2007 Bolivia Indigenous Child <5 yrs D

E2397 B1 443 L5 O167 FII, FrepB, X1 LT+STh CS5+CS6 2007 Bolivia Indigenous Child <5 yrs D

E5080 B1 443 L5 O115 FIIY LT+STh CS5+CS6 2011 Bangladesh Indigenous Adult D




E562 A 2332 L6 ON3 FIB, I1, P STh CFA/I+CS21 2000 Mexico Traveller Adult D/AS

E563 A 2332 L6 ON3 FIB, FII-s, I1, P STh CFA/I+CS21 2000 Mexico Traveller Adult D/AS

E636 A 2332 L6 ON3 FIB, FII-s, P STh CFA/I+CS21 2000 Guatemala Traveller Adult D

E897 A 274 L6 ON3 FIB, FII-s, P STh CFA/I+CS21 2003 Guatemala Indigenous Child <5 yrs D

E986 A 2332 L6 O71 FIB, FrepB, K STh CFA/I+CS21 1997 Egypt Soldier Adult D

E1548 A 2332 L6 ON3 FIB, I1 STh CFA/I+CS21 1989 Argentina Indigenous Child <5 yrs D

E1604 A 2332 L6 ON3 FII, FIB, FrepB,

I1, P STh CFA/I+CS21 1989 Argentina Indigenous Child <5 yrs D

E344 D/E 182 L7 O169 FII, FIIY, FIB,

FrepB STp CS6 1998 Mexico Traveller Adult D/AS

E370 D/E 182 L7 O169 FII, FIIY, FrepB STp CS6 1998 Guatemala Traveller Adult D/AS

E520 D/E 182 L7 O169 FII, FIB, FrepB STp CS6 2000 Mexico Traveller Adult D/AS


FrepB STp CS6 2000 Mexico Traveller Adult D/AS


FrepB, X1 STp CS6 2001 Egypt Indigenous Child <5 yrs D

E1328 D 182 L7 O169 FII, FIIY, FIB,

FrepB STp CS6+CS21 1996 Kenya Traveller Adult D


FrepB STp CS6+CS21 1996 Kenya Traveller Adult D

E1334 A n.i. L7 n.i. FII, FIIY, FIB,

FrepB STp CS6 1996 China Traveller Adult D

E1373 D/E 182 L7 O169 FII, FIIY, FIB, FII-s, FrepB STp CS6 1996 Indonesia Traveller Adult D


FrepB STp CS6 2003 Guinea Bissau Indigenous Child <5 yrs AS


FII-s, FrepB, P STp CS6 2007 Thailand Soldier Adult D

E5084 D/E 182 L7 O169 FII, FIIY, FIB, FII-s, FrepB STp CS6 2011 Bangladesh Indigenous Adult D

E222 B1 94 L8 O148 FIB ST CS21 1987 Japan Traveller Adult D

E224 B1 448 L8 O148 FII, FIB, FrepB STh CS6+CS21 1987 Japan Traveller Adult D

E335 B1 94 L8 O148 FII, FIB, FrepB LT+STp CS6+CS21 1998 Mexico Traveller Adult D/AS

E336 B1 94 L8 O148 FII, FIB, FrepB LT+STp CS6+CS21 1998 Mexico Traveller Adult D/AS

E1189 B1 94 L8 O148 FII, FIB, FrepB STh CS6+CS21 2001 Egypt Indigenous Child <5 yrs D


E1352 B1 94 L8 O148 FII, FIB, FrepB STh CS6+CS21 1996 Egypt Traveller/S

oldier Adult D

E1355 B1 94 L8 O148 FII, FIB, FrepB STh CS6+CS21 1996 Egypt Traveller Adult D

E1356 B1 94 L8 O148 FII, FIB, FrepB STh CS6+CS21 1996 Egypt Traveller Adult D

E2108 B1 94 L8 O148 FII, FIB LT+STp CS6+CS21 2007 Bangladesh ENV ENV ENV



E220 A 398 L9 O27 FII, FIB, FrepB STp CS6 1987 Japan Traveller Adult D

E223 A 398 L9 O27 n.i. ST CF NEG 1987 Japan Traveller Adult D


I1 STp CS6 1987 Japan Traveller Adult D

E251 A 398 L9 O78 FII, FIB, FrepB STh CF NEG 1987 Japan Traveller Adult D


HI1 STp CS6 2002 Guatemala Traveller Adult D


HI1 STp CS6 2003 Guatemala Indigenous Child <5 yrs D





E879 A 398 L9 O27 FIB STp CS6 2003 Guatemala Indigenous Child <5 yrs D

E927 A 1497 L9 O159 FIB, FrepB STp CS6 1997 Egypt Soldier Adult D

E940 A 398 L9 O167 FIB, FrepB STp CS6 1997 Egypt Soldier Adult D

E943 A 1497 L9 O159 FII, FIB, FrepB STp CS6 1997 Egypt Soldier Adult D

E934 A 2368 L10 O114 FII, FrepB LT+STp CS19 1997 Egypt Soldier Adult D






E1167 A 2368 L10 O114 FII, FrepB LT+STp CS19 2001 Egypt Indigenous Child <5 yrs D

E1248 A 2368 L10 O114 FII, FIIK, FIIY,

FrepB LT+STp CS19 2001 Egypt Indigenous Child <5 yrs D




FrepB LT+STp CS19 2001 Egypt Indigenous Child <5 yrs D



E159 A 218 L11 O159 FII, FIIY, FIB LT CF NEG 1983 Japan Traveller Adult D

E167 A 10 L11 ON14 FII, FIIY LT CF NEG 1983 Japan Traveller Adult D

E451 A 3856 L11 O56 FII, FIB, FrepB LT CF NEG 2000 Guatemala Traveller Adult D/AS

E883 A 206 L11 O60 FII, FIIY,

FrepB, HI1 LT+ST CF NEG 2003 Guatemala Indigenous Child <5 yrs D

E947 A 10 L11 O15

FII, FIIS, FIIY, FIB, FrepB, I1,

X1 LT+STp CF NEG 1997 Egypt Soldier Adult D


FIB, FrepB LT+STp CF NEG 2000 Egypt Indigenous Child <5 yrs AS

E1542 A 1303 L11 ON5 FII, FIIS, FIB,

FrepB LT CF NEG 1989 Argentina Indigenous Child <5 yrs D

E1634 A 206 L11 O105 FII-s, FrepB, I1 LT CF NEG 1990 Indonesia Indigenous Child <5 yrs D

E1690 A 2758 L11 O40 FII, FrepB ST CF NEG 1990 Indonesia Indigenous Child <5 yrs D

E2371 A 218 L11 O174-like FII, FIB, FrepB,

I1 LT CF NEG 2008 Bolivia Indigenous Child <5 yrs D

E5052 A 10 L11 O64 FII, FIB, FII-s,

FrepB, P LT CS6 unknown India Indigenous Child <5 yrs D

E2370sc A 218 L11 O174 FII, FIB, FrepB,

I1 LT+ST CF NEG 2008 Japan Indigenous Child <5 yrs D

E5089sc A 2345 L11 O174-like FII, FIA, FrepB,

I1, X1 LT+ST CS23 2011 Bangladesh Indigenous Adult D

E330 A 731 L12 O15 n.i. LT CF NEG 1998 Mexico Traveller Adult D/AS

E405 A 731 L12 O15 FII, FrepB LT CF NEG 1999 Guatemala Traveller Adult D/AS

E1556 A 731 L12 O15 FII, FrepB LT CF NEG 1989 Argentina Indigenous Child <5 yrs D

E1561 A 731 L12 O15 n.i. LT CF NEG 1989 Argentina Indigenous Child <5 yrs D

E1596 A 731 L12 O15 FII, FII-s, FrepB LT CF NEG 1989 Argentina Indigenous Child <5 yrs D

E399 A 100 L13 O112ab FII, FIB, FrepB LT CF NEG 1999 Guatemala Traveller Adult D/AS

E604 A 165 L13 OSB16 FIB LT+STp CF NEG 2000 Guatemala Traveller Adult D


E616 A 165 L13 OSB16 FIB, I1 LT+STp CF NEG 2000 Guatemala Traveller Adult D

E628 A 165 L13 OSB16 FIB, I1 LT+STp CF NEG 2000 Guatemala Traveller Adult AS

E855 A 165 L13 OSB16 FII, FrepB LT CF NEG 2003 Guatemala Indigenous Child <5 yrs D

E952 A 165 L13 O114 FII, FrepB LT CF NEG 1997 Egypt Soldier Adult D

E1525 A 750 L13 OSB16 FII, FIB, FrepB LT+STh CF NEG 1989 Argentina Indigenous Child <5 yrs D

E1574 A 750 L13 OSB16 FIB, X4 LT CF NEG 1989 Argentina Indigenous Child <5 yrs D

E1580 A 165 L13 O160 FIB LT+STp CF NEG 1989 Argentina Indigenous Child <5 yrs D

E1581 A 10 L13 OSB16 FII, FrepB LT CF NEG 1989 Argentina Indigenous Child <5 yrs D

E1582 A 100 L13 O179 FII, FIB, FrepB LT CF NEG 1989 Argentina Indigenous Child <5 yrs D


I1 LT CF NEG 1989 Argentina Indigenous Child <5 yrs D

E1600 A 100 L13 O112ab FII, FIIY, FrepB

x2, K LT CF NEG 1989 Argentina Indigenous Child <5 yrs D

E1615 A 100 L13 O112ab I1 LT CF NEG 1989 Argentina Indigenous Child <5 yrs D

E620 A 1684 L14 ON5 n.i. ST CF NEG 2000 Guatemala Traveller Adult AS

E626 A 10 L14 ON5 n.i. ST CF NEG 2000 Guatemala Traveller Adult D



E1193 A 10 L14 ON5 n.i. ST CF NEG 2001 Egypt Indigenous Child <5 yrs D

E811sc A 2705 L14 ON5 n.i. ST CF NEG 2002 Guatemala Traveller Adult D

E28 A 10 L15 O128 FIIY ST CF NEG 1980 Bangladesh Indigenous All ages D

E133 A 10 L15 O159 FII LT+STp CS12 1989 unknown Indigenous unknown D

E160 A 10 L15 O133 FIIY LT CF NEG 1983 Japan Traveller Adult D


FrepB, I1 LT CF NEG 1998 Mexico Traveller Adult D/AS

E354 A 10 L15 ON5 FII, FIIY, FIB,

FrepB, HI1 ST CF NEG 1998 Mexico Traveller Adult D/AS

E356 A 10 L15 ON5 FII, FIIY, FrepB ST CF NEG 1998 Mexico Traveller Adult D/AS

E415 A 10 L15 O182 FIIY, FIB LT CS6 1999 Guatemala Traveller Adult D/AS


FrepB LT CS6 1999 Guatemala Traveller Adult D/AS


E513 A 10 L15 ON5 FIIY, N ST CF NEG 2000 Mexico Traveller Adult D/AS

E828 A 1290 L15 ON5 FIIY ST CF NEG 2002 Guatemala Traveller Adult D

E882 A 10 L15 OC6 FII, FIIS, FIIY,

FrepB LT+STp CS12 2003 Guatemala Indigenous Child <5 yrs D

E898 A 10 L15 O182 FII, FIB, FrepB LT CS6 2003 Guatemala Indigenous Child <5 yrs D

E941 A 43 L15 O114 FII, FIIY, FrepB LT CF NEG 1997 Egypt Soldier Adult D


FrepB, K STh CFA/I+CS21 2000 Egypt Indigenous Child <5 yrs D/AS

E1101 A 167 L15 OC14-like FII, FIIS, FIIY,

FrepB, X1 LT+STp CF NEG 2000 Egypt Indigenous Child <5 yrs AS


FrepB STh CFA/I+CS21 2001 Egypt Indigenous Child <5 yrs D



E1573 A 10 L15 O159 FII, FIB, FII-s,


E1594 A 10 L15 ON5 FII, FrepB ST CF NEG 1989 Argentina Indigenous Child <5 yrs D


FrepB STh CFA/I+CS21 2007 Bangladesh Indigenous Child <5 yrs D

E2377 A 10 L15 O182 FII, FIIY, FrepB LT CS6 2007 Bolivia Indigenous Child <5 yrs D


FrepB LT CF NEG 2007 Bolivia Indigenous Child <5 yrs D

E1432G A 34 L15 O92 FII, FIIS, FIIY,

FrepB LT CF NEG 1997 Venezuela Traveller Adult D

E1679sc A 10 L15 O159 FII, FrepB LT+STp CS12 1990 Indonesia Indigenous Child <5 yrs D


FrepB LT+STh CS3+CS21 1986 Bangladesh Indigenous All ages D


FrepB LT CS3+CS21 1987 Bangladesh Indigenous All ages D

E351 A 410 L16 O8 FII, FIB, FrepB LT CF NEG 1998 Mexico Traveller Adult D/AS

E360 A 23 L16 O8 FII, FIIY, FII-s,

FrepB, I1 LT CS1 1998 Mexico Traveller Adult D/AS


FrepB, I1 LT CS1 2000 Guatemala Traveller Adult D/AS


FrepB, P LT+STh CS3+CS21 2002 Guatemala Traveller Adult D

E841 A 6 L16 O8 FII, FrepB LT CS8 2003 Guatemala Traveller Adult D

E1102 A 88 L16 ON5 FII, FIIY, FII-s, FrepB, I1, P, ST CF NEG 2000 Egypt Indigenous Child <5 yrs AS


X4

E1524 A n.i. L16 n.i. FIIY STh CS14 1989 Argentina Indigenous Child <5 yrs D

E1526 A 23 L16 ON5 FII, FII-s, FrepB ST CF NEG 1989 Argentina Indigenous Child <5 yrs D

E1607 A 23 L16 O78 FII, FIIY, FIB, FII-s, FrepB LT CS14 1989 Argentina Indigenous Child <5 yrs D

E1611 A 88 L16 O8 and O104 FII, FIB, FII-s,

FrepB LT CS6 1989 Argentina Indigenous Child <5 yrs D

E1623 A 23 L16 ON5 FII, FIIS, FIA,

FIB, FrepB ST CF NEG 1990 Indonesia Indigenous Child <5 yrs D

E1637 A 23 L16 ON5 FII, FIIS, FIA,

FIB, FrepB ST CF NEG 1990 Indonesia Indigenous Child <5 yrs D

E1674 A 23 L16 ON5 FII, FIA, FIB, FrepB, FII-s ST CF NEG 1990 Indonesia Indigenous Child <5 yrs D

E1961 A 3864 L16 O8 FII, FIB, FII-s,

FrepB LT+STp CS19 2007 Bangladesh Indigenous Child <5 yrs D


K, Y LT CS17 2007 Bolivia Indigenous Child <5 yrs D

E2348 A 6 L16 ON4

FII, FIIY, FIA, FIB, FrepB, FII-

s LT+STh CF NEG 2007 Bolivia Indigenous Child <5 yrs D

E2393 A 23 L16 O8 FII, FIIY, FrepB, I1 LT CS1 2007 Bolivia Indigenous Child <5 yrs D


FIB, FrepB LT CS17 1989 Zaire Indigenous unknown D

E333 B1 316 L17 O27 FII, FIB, PrepB,

K, X1 STp CS6 1998 Mexico Traveller Adult D/AS


K, X1 STp CS6 1999 Guatemala Traveller Adult D/AS

E842 B1 316 L17 O27 FII, FIB, FrepB STp CS6 2003 Guatemala Traveller Adult D

E895 B1 316 L17 O27 FII, FIB, FrepB STp CS6 2003 Guatemala Indigenous Child <5 yrs D

E908 B1 278 L17 n.i. FII, FrepB ST CF NEG 2004 Guatemala Indigenous Child <5 yrs D

E1392 B1 316 L17 O27 FII, FIB, FrepB STp CS6 1996 Indonesia Traveller Adult D

E1398 B1 316 L17 O27 FII, FIB, FrepB STp CS6 1996 Indonesia Traveller Adult D

E1512 B1 316 L17 O27 FII, FIB, FrepB STp CS6 2003 Guinea Bissau Indigenous Child <5 yrs AS

E1523 B1 316 L17 O27 FII, FIB, FrepB STp CS6 2003 Guinea Bissau Indigenous Child <5 yrs AS


X1 STp CS6 1990 Indonesia Indigenous Child <5 yrs D

E1712 B1 n.i. L17 O98 FII, FIB, FrepB, LT CS14 2001 Bangladesh Indigenous All ages D


I1, K

E1735 B1 n.i. L17 O98 FII, FIB, FrepB,

I1, K LT+STh CS14 2002 Bangladesh Indigenous All ages D

E1736 B1 n.i. L17 O98 FII, FIB, FrepB,

I1, K LT+STh CS14 2002 Bangladesh Indigenous All ages D

E1744 B1 328 L17 O88 FII, FIIS, FIB,

FrepB LT CF NEG 2002 Bangladesh Indigenous All ages D

E1871 B1 n.i. L17 O98 FII, FIIY, FIB,

FrepB, I1 LT+STh CS14 2007 Bangladesh Indigenous Child <5 yrs AS


FIB, FrepB LT CF NEG 2008 Bolivia Indigenous Child <5 yrs D


FIB, FrepB, HI1 LT CF NEG 2008 Bolivia Indigenous Child <5 yrs D

E3015 B1 316 L17 O27 FII, FIB, FII-s,

FrepB, P STp CS6 1998 Egypt Indigenous Child <5 yrs D

E391 B1 641 L18 O159 FIB, FII-s, I1 LT CF NEG 1999 Guatemala Traveller Adult D/AS

E519 B1 3857 L18 O159 FII, FrepB LT CF NEG 2000 Mexico Traveller Adult D/AS

E527 B1 641 L18 O159 FII, FII-s, FrepB LT CF NEG 2000 Mexico Traveller Adult D/AS

E528 B1 3857 L18 O64 I1 LT CF NEG 2000 Mexico Traveller Adult D/AS

E659 B1 641 L18 O133 FII, FIIY, FIB,

FII-s, FrepB, P LT CF NEG 2001 Guatemala Traveller Adult AS

E818 B1 3867 L18 O64 n.i. LT CS13 2002 Guatemala Traveller Adult D

E819 B1 3858 L18 ON15 FII, FIB, FII-s,

FrepB, P LT CF NEG 2002 Guatemala Traveller Adult D


FrepB, P LT CF NEG 2002 Guatemala Traveller Adult D

E833 B1 641 L18 O159 FII, FIIK, FrepB LT CS28a 2003 Guatemala Traveller Adult D

E885 B1 641 L18 O159 FII, FIB, FII-s,

FrepB, P LT CF NEG 2003 Guatemala Indigenous Child <5 yrs D

E899 B1 641 L18 O133 FII, FIIY, FIB,

FrepB, I1 LT CF NEG 2003 Guatemala Indigenous Child <5 yrs D

E1640 B1 641 L18 O159 FII, FrepB LT+ST CF NEG 1990 Indonesia Indigenous Child <5 yrs D

E5085 B1 1490 L18 O159 FII, FIB STp CS6 2011 Bangladesh Indigenous Adult D

E5088 B1 1490 L18 O159 FIB STp CS6 2011 Bangladesh Indigenous Adult D

E126 B1 58 L19 O166 FII, FIIY, FIB, FII-s, FrepB STh CS14 1989 unknown Indigenous unknown D

E622 B1 2340 L19 O58 FII, FrepB, P LT CF NEG 2000 Guatemala Traveller Adult AS



FrepB, P LT CF NEG 2000 Guatemala Traveller Adult AS

E884 B1 2340 L19 O58 FII, FrepB, P LT CF NEG 2003 Guatemala Indigenous Child <5 yrs D

E887 B1 155 L19 O170 FII, FrepB ST CF NEG 2003 Guatemala Indigenous Child <5 yrs D

E891 B1 155 L19 O154 FII, FIB, FII-s,

FrepB ST CF NEG 2003 Guatemala Indigenous Child <5 yrs D

E892 B1 155 L19 O170 FII, FrepB ST CF NEG 2003 Guatemala Indigenous Child <5 yrs D

E907 B1 6 L19 O128 FII, FIIY, FrepB STh CS14 2004 Guatemala Indigenous Child <5 yrs D

E920 B1 58 L19 O128 FII, FIIY, FrepB

x2, K STh CS14 2003 Guatemala Indigenous Child <5 yrs D

E928 B1 223 L19 O78 FII, FIIY, FIB, P STh CS14 1997 Egypt Soldier Adult D

E1673 B1 155 L19 O38 FII, FIB, FII-s,

FrepB ST CF NEG 1990 Indonesia Indigenous Child <5 yrs D

E1682 B1 616 L19 ON13 FIB LT CF NEG 1990 Indonesia Indigenous Child <5 yrs D

E1360sc B1 155 L19 O21 FII, FrepB ST CF NEG 1996 Tunisia Traveller Adult D

E361 B1 940 L20 O64 FII, FIIY, FrepB LT+STp CS13 1998 Mexico Traveller Adult D/AS

E873 B1 940 L20 O64 FII, FIIY, FrepB, P LT+STp CF NEG 2003 Guatemala Indigenous Child <5 yrs D

E881 B1 940 L20 O64 FII, FIIY, FrepB, P LT+STp CF NEG 2003 Guatemala Indigenous Child <5 yrs D


FIB, FrepB LT CS6 1996 Mexico Traveller Adult D

E1576 B1 940 L20 O64 FII, FIIY, FrepB LT CF NEG 1989 Argentina Indigenous Child <5 yrs D

E2395 B1 940 L20 O63 FII, FIIY, FIB,

FrepB, K STh CS14 2007 Bolivia Indigenous Child <5 yrs D


FIB, FrepB LT CF NEG 2000 Mexico Traveller Adult D/AS

E876 A 46 L21 O9 FII, FIIY, FrepB LT CS20 2003 Guatemala Indigenous Child <5 yrs D

E1564 A 609 L21 O9 FII, FIB, FrepB LT CF NEG 1989 Argentina Indigenous Child <5 yrs D

E1609 A 3861 L21 O8 FII, FrepB LT CF NEG 1989 Argentina Indigenous Child <5 yrs D

E2367 A 46 L21 O9 FII, FrepB LT CF NEG 2008 Bolivia Indigenous Child <5 yrs D

E97 A 96

O25 FII, FIIS, FIIY, FrepB x2, K LT+STp CS4+CS6 1988 Bangladesh Indigenous Child <5 yrs D

E106 A 96

O25 FII, FIIS, FIIY, FrepB x2, K LT+STp CS4+CS6 1985 unknown Indigenous unknown D

E151 B1 52

OC15 FII, FIIY, FrepB LT CS12 1983 Japan Traveller Adult D


E239 D/E 394

OC15 FII, FIIY, FrepB LT+STp CF NEG 1987 Japan Traveller Adult D

E390 B1 3855

ON5 FII, FIA, FIB,

FrepB ST CF NEG 1999 Guatemala Traveller Adult AS

E523 B2 142

O71 FIB, I1, P ST CF NEG 2000 Mexico Traveller Adult D/AS

E618 B1 295

ON5 n.i. ST CF NEG 2000 Guatemala Traveller Adult AS

E662 A 93

O7 FII, FIIS, FIIY,

FrepB LT CF NEG 2001 Guatemala Traveller Adult AS

E703 B1 295


E888 B1 101

O103 P, Y ST CF NEG 2003 Guatemala Indigenous Child <5 yrs D

E890 B1 3855

ON5 FII, FIA, FIB,

FrepB ST CF NEG 2003 Guatemala Indigenous Child <5 yrs D

E893 B1 101

O88 FII, FIB, FrepB ST CF NEG 2003 Guatemala Indigenous Child <5 yrs D

E901 D/E 1380

OC15 FII, FIIS, FIIY,

FrepB LT CF NEG 2003 Guatemala Indigenous Child <5 yrs D

E936 B1 295

O39 FII, FrepB LT+ST CF NEG 1997 Egypt Soldier Adult D

E939 B1 1325

O39 FII, FIB, FrepB ST CF NEG 1997 Egypt Soldier Adult D

E949 A 48

OSB16 FII, FIIS, FIIY, FIB, FrepB, Y LT CF NEG 1997 Egypt Soldier Adult D

E956 A 48

ON3 FIB, Y LT CF NEG 1997 Egypt Soldier Adult D

E996 D/E 3859

O4 FII, FIIY, FrepB STh CS6 1997 Egypt Soldier Adult D

E998 B1 295

ON5 FIB, I1 ST CF NEG 1997 Egypt Soldier Adult D

E1072 B1 747

OC15 FII, FIIY, FrepB LT+STp CF NEG 2000 Egypt Indigenous Child <5 yrs AS

E1169 B1 747

OC15 FII, FIIY, FrepB LT+STp CF NEG 2001 Egypt Indigenous Child <5 yrs D

E1242 B1 120

n.i. FII, FrepB LT+STp CS18 2001 Egypt Indigenous Child <5 yrs D

E1282 B1 500

ON5 n.i. ST CF NEG 2001 Egypt Indigenous Child <5 yrs D

E1460 D/E 117

O111-like FII, FIB, FII-s,

FrepB ST CF NEG 1997 Indonesia Traveller/S

oldier Adult D

E1527 B1 7

O128 FII, FIIY, K STh CS5+CS6 1989 Argentina Indigenous Child <5 yrs D

E1533 A 1494

O9-like FII, FII-s, FrepB, Y LT+STp CF NEG 1989 Argentina Indigenous Child <5 yrs D

E1534 B1 6

ON5 n.i. ST CF NEG 1989 Argentina Indigenous Child <5 yrs D

E1543 A 64

OC14 FII-s, I1, X1 STh CF NEG 1989 Argentina Indigenous Child <5 yrs D

E1544 A 64

OC14 FII-s, I1, X1 STh CF NEG 1989 Argentina Indigenous Child <5 yrs D


E1586 A n.i.

O9 FII, FrepB LT+STp CF NEG 1989 Argentina Indigenous Child <5 yrs D

E1593 B1 7

O128 FII, FII-s STh CS5+CS6 1989 Argentina Indigenous Child <5 yrs D

E1597 D/E 4

O7 FII, FIIY, FII-s,

FrepB LT+STp CF NEG 1989 Argentina Indigenous Child <5 yrs D

E1599 B1 295

ON5 n.i. ST CF NEG 1989 Argentina Indigenous Child <5 yrs D

E1616 B1 101

O93 FII, FIB, FrepB,

X4 LT CF NEG 1989 Argentina Indigenous Child <5 yrs D

E1617 D/E 4

O7 FII, FrepB LT+STp CF NEG 1989 Argentina Indigenous Child <5 yrs D

E1638 B1 3188

ON5 n.i. ST CF NEG 1990 Indonesia Indigenous Child <5 yrs D

E1641 D/E 38

O7 FII, FIIS, FIIY,

FIB, FrepB LT CF NEG 1990 Indonesia Indigenous Child <5 yrs D

E1642 B2 52

ON16 FII, FrepB LT+STp CF NEG 1990 Indonesia Indigenous Child <5 yrs D

E1647 B1 3862

ON17 FII, FrepB LT CS6+CS21 1990 Indonesia Indigenous Child <5 yrs D

E1650 B1 3863

ON13 FII-s LT CF NEG 1990 Indonesia Indigenous Child <5 yrs D

E1657 B1 1308

ON2 FII, FrepB LT+STp CS12 1997 Indonesia Traveller/S

oldier Adult D

E1659 B1 200

O175 FII, FrepB LT CF NEG 1990 Indonesia Indigenous Child <5 yrs D

E1661 D/E 394

OC15 FII, FrepB LT+STp CF NEG 1990 Indonesia Indigenous Child <5 yrs D

E1784 B1 9

O19 FII, FrepB STh CS6 2005 Bangladesh Indigenous Adult unknown

E2388 D/E 349

O166 FII, FIB, FII-s,

FrepB, P LT CF NEG 2007 Bolivia Indigenous Child <5 yrs D

E5049 B1 n.i.

n.i. FIIY, FIB, FII-s LT CS6 unknown India Indigenous Child <5 yrs D

E5051 B1 295

O159 FII, FIB, FrepB,

I1 LT CS6 unknown India Indigenous Child <5 yrs D

E5087 D/E 405

O102 FII, FIIY, FIA, FIB, FrepB, K ST CF NEG 2011 Bangladesh Indigenous Adult D

E1432w D/E 394

OC15 FII, FIIY, FrepB LT CF NEG 1997 Venezuela Traveller Adult D

E2362sc D/E 349

O166 P ST CF NEG 2008 Bolivia Indigenous Child <5 yrs D

E2439sc B2 131

O25-like FIA, FIB, FrepB ST CF NEG 2008 Bolivia Indigenous Child <5 yrs D

E2981sc D/E 354

ON3 FII, FIA, FIB,

FrepB LT CF NEG 2010 Bangladesh unknown unknown unknown

E509sc B1 295

ON5 FIIY ST CF NEG 2000 Mexico Traveller Adult D/AS

E621sc B1 3188



E710sc B1 3188


E957sc A 48

O15 FII, FIIS, FIIY, FIB, FrepB, Y LT CF NEG 1997 Egypt Soldier Adult D

1 n.i.: not identified 2 N: novel O antigen 3 C: O antigen gene cluster 4 –like: diversified O antigen 5 CF: Colonization factor 6 CF NEG: CF “negative” 7 D/AS/ENV: Diarrhea/Asymptomatic/Environmental


Supplementary Table 3 List of sample accession for all 362 ETEC isolates included in the study. Use ERS-numbers to locate sequencing information and sequence data for each sample. Isolate (UG designation) ERS-number

E8 ERS038927

E21 ERS044456

E28 ERS044457

E36 ERS044458

E45 ERS044459

E54 ERS038929

E66 ERS044460

E70 ERS038930

E71 ERS038931

E74 ERS044461

E79 ERS044462

E85 ERS044463

E87 ERS044464

E88 ERS038932

E97 ERS044465

E99 ERS044466

E106 ERS044455

E110 ERS044467

E126 ERS044468

E129 ERS044469

E133 ERS044470

E135 ERS044471

E141 ERS044472

E143 ERS044473

E151 ERS044474

E157 ERS077703

E159 ERS077713

E160 ERS077719

E167 ERS077743

E220 ERS044475

E222 ERS077576

E223 ERS077577

E224 ERS044476

E237 ERS044477

E239 ERS077578

E251 ERS044478

E263 ERS077579

E272 ERS044479

E329 ERS077580


E330 ERS077581

E333 ERS038933

E335 ERS077582

E336 ERS077583

E340 ERS077584

E343 ERS077585

E344 ERS038934

E351 ERS077586

E354 ERS077587

E356 ERS077588

E360 ERS077589

E361 ERS077590

E370 ERS038935

E390 ERS077591

E391 ERS077592

E399 ERS077593

E405 ERS077594

E415 ERS077595

E416 ERS038936

E425 ERS077596

E445 ERS077597

E451 ERS077598

E471 ERS038937

E509 ERS139279

E513 ERS077600

E517 ERS038938

E519 ERS077601

E520 ERS077602

E523 ERS077603

E527 ERS077604

E528 ERS077605

E529 ERS077606

E554 ERS038939

E562 ERS038940

E563 ERS038941

E604 ERS077607

E616 ERS077608

E618 ERS077609

E620 ERS077610

E621 ERS139280

E622 ERS077612

E626 ERS077613

E628 ERS077614

E632 ERS038942

E636 ERS038943


E645 ERS077615

E655 ERS038944

E658 ERS077616

E659 ERS077617

E662 ERS077618

E703 ERS077619

E704 ERS077620

E705 ERS077621

E710 ERS139281

E806 ERS044480

E810 ERS044481

E811 ERS139282

E812 ERS044482

E816 ERS044483

E818 ERS077624

E819 ERS077625

E821 ERS077626

E822 ERS044484

E828 ERS077627

E833 ERS077628

E841 ERS077629

E842 ERS044485

E855 ERS077630

E856 ERS044486

E858 ERS044487

E860 ERS077631

E863 ERS038945

E865 ERS077632

E867 ERS044488

E871 ERS044489

E873 ERS077633

E876 ERS077634

E877 ERS038946

E879 ERS038947

E881 ERS077635

E882 ERS044490

E883 ERS044491

E884 ERS077637

E885 ERS077638

E887 ERS077639

E888 ERS077640

E890 ERS077641

E891 ERS077642

E892 ERS077643

E893 ERS077644


E895 ERS044492

E897 ERS038948

E898 ERS077645

E899 ERS077646

E900 ERS044493

E901 ERS044494

E903 ERS044495

E907 ERS044496

E908 ERS077648

E916 ERS038949

E917 ERS038950

E920 ERS044497

E924 ERS077649

E925 ERS038951

E927 ERS038952

E928 ERS044498

E934 ERS077651

E935 ERS077652

E936 ERS077653

E938 ERS038953

E939 ERS077654

E940 ERS038954

E941 ERS077655

E943 ERS044499

E944 ERS077656

E945 ERS077657

E947 ERS077658

E949 ERS077659

E952 ERS077660

E953 ERS038955

E955 ERS077661

E956 ERS077662

E957 ERS136430

E978 ERS077664

E986 ERS038956

E995 ERS127431

E996 ERS077665

E998 ERS077666

E1003 ERS044500

E1009 ERS044501

E1018 ERS055619

E1034 ERS038957

E1057 ERS077667

E1072 ERS077668

E1074 ERS038958


E1085 ERS038959

E1091 ERS038960

E1101 ERS077669

E1102 ERS077670

E1111 ERS038961

E1114 ERS206736

E1115 ERS206737

E1116 ERS206738

E1117 ERS206739

E1118 ERS206740

E1119 ERS206741

E1120 ERS206742

E1121 ERS206743

E1122 ERS206744

E1167 ERS077671

E1169 ERS077672

E1189 ERS038962

E1193 ERS077673

E1242 ERS077674

E1245 ERS038963

E1248 ERS077675

E1258 ERS077676

E1264 ERS077677

E1281 ERS077678

E1282 ERS077679

E1285 ERS077680

E1287 ERS038964

E1298 ERS038965

E1316 ERS127432

E1328 ERS206745

E1329 ERS206746

E1334 ERS055620

E1352 ERS077681

E1355 ERS077682

E1356 ERS077683

E1360 ERS139284

E1362 ERS077685

E1363 ERS055622

E1365 ERS077686

E1373 ERS038966

E1392 ERS038967

E1398 ERS077687

E1407 ERS077688

E1433 ERS055624

E1441 ERS206747


E1442 ERS206748

E1460 ERS055625

E1484 ERS206752

E1512 ERS206753

E1516 ERS206754

E1523 ERS206755

E1524 ERS055626

E1525 ERS077692

E1526 ERS077693

E1527 ERS055627

E1532 ERS077694

E1533 ERS077695

E1534 ERS077696

E1535 ERS055628

E1541 ERS038968

E1542 ERS077697

E1543 ERS077698

E1544 ERS077699

E1548 ERS038969

E1556 ERS077700

E1561 ERS077701

E1564 ERS077702

E1573 ERS077704

E1574 ERS077705

E1576 ERS077706

E1580 ERS077707

E1581 ERS077708

E1582 ERS077709

E1585 ERS077710

E1586 ERS077711

E1587 ERS077712

E1592 ERS077714

E1593 ERS055629

E1594 ERS077715

E1596 ERS077716

E1597 ERS077717

E1599 ERS077718

E1600 ERS077720

E1604 ERS077721

E1607 ERS077722

E1609 ERS077723

E1611 ERS077724

E1615 ERS077725

E1616 ERS077726

E1617 ERS077727


E1620 ERS055630

E1623 ERS077728

E1624 ERS038970

E1625 ERS077729

E1628 ERS077730

E1634 ERS077731

E1635 ERS055631

E1637 ERS077732

E1638 ERS077733

E1640 ERS077734

E1641 ERS077735

E1642 ERS077736

E1646 ERS038971

E1647 ERS077737

E1648 ERS077738

E1649 ERS055632

E1650 ERS077739

E1654 ERS044454

E1657 ERS055633

E1659 ERS077740

E1661 ERS077741

E1666 ERS077742

E1667 ERS055634

E1673 ERS077744

E1674 ERS077745

E1679 ERS163315

E1682 ERS077747

E1684 ERS077748

E1690 ERS077749

E1712 ERS077750

E1716 ERS038972

E1724 ERS055635

E1735 ERS077751

E1736 ERS077752

E1739 ERS077753

E1741 ERS055636

E1744 ERS077754

E1750 ERS055637

E1752 ERS077755

E1760 ERS055638

E1779 ERS038973

E1784 ERS038974

E1795 ERS055639

E1797 ERS055640

E1841 ERS055641


E1871 ERS077756

E1883 ERS055642

E1918 ERS055643

E1939 ERS055644

E1947 ERS055645

E1961 ERS077757

E1994 ERS055646

E2088 ERS055647

E2092 ERS055648

E2108 ERS077758

E2110 ERS077759

E2118 ERS055649

E2121 ERS077760

E2131 ERS055650

E2185 ERS055651

E2219 ERS055652

E2256 ERS055653

E2339 ERS055654

E2347 ERS055655

E2348 ERS055656

E2362 ERS139286

E2367 ERS077762

E2370 ERS163317

E2371 ERS077764

E2377 ERS077765

E2386 ERS055657

E2388 ERS077766

E2392 ERS077767

E2393 ERS077768

E2395 ERS077769

E2397 ERS055658

E2404 ERS077770

E2405 ERS077771

E2439 ERS136438

E2980 ERS055659

E2981 ERS139299

E3015 ERS077773

E4134 ERS077774

E5049 ERS055663

E5051 ERS055664

E5052 ERS055665

E5080 ERS055666

E5081 ERS055667

E5082 ERS055668

E5084 ERS055669


E5085 ERS055670

E5086 ERS055671

E5087 ERS055672

E5088 ERS055673

E5089 ERS136435

E1429tiny ERS163313

E1432G ERS136432

E1432w ERS136512


nature genetics: doi:10.1038/ng · heat map depicting the virulence profiles, o antigens and...

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