natural selection in action - used
TRANSCRIPT
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Natural Selection in Action
Higher Biology
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Natural Selection in Action• Most mutations produce inferior versions of original
gene
• Some mutations allow adaption to a changing environment
• Mutant allele gives mutant form of organism a selective advantage
• Change in environment-abiotic factor (e.g. pollution)-biotic factor (e.g. disease)
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Sickle cell anaemia• Genetically transmitted disease of
the blood
• Caused by presence of abnormal haemoglobin S
• Abnormality occurs as result of mutation
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Haemoglobin S• H – allele for normal haemoglobin• S – allele for haemoglobin S
• People homozygous for mutant allele (SS)-sickle-shaped red blood cells-inefficient at carrying oxygen-cells clump together interfering with circulation
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Symptoms of Sickle Cell Anaemia• Fatigue
• Breathlessness• rapid heart rate• delayed growth and puberty• susceptibility to infections• ulcers on the lower legs (in adolescents and adults) • jaundice• attacks of abdominal pain• weakness• joint pain• fever• Vomiting• bloody (hematuria) urination• excessive thirst• excessive penis pain• Priapism• chest pain• decreased fertility
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Incomplete dominance• Allele H incompletely dominant to allele S
• Heterozygotes – HS
• Allele S partially expressed
• Sickle Cell Trait-a third of the haemoglobin is S
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Sickle Cell Anemia in Africa
• Allele S rare in populations as semi-lethal
• Some parts of Africa up to 40% of population is HS
• People with Sickle Cell Trait resistant to malaria
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Distribution of malaria Distribution of sickle
cell trait
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Sickle Cell Trait and Malaria
• In malarial regions-natural selection favours people with genotype HS
• People that are HH will die during serious outbreaks of the disease
• Hs loses selective advantage in non-malarial sites
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Paper Question : Paper 3, S09, Q5
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Use text books to answer this question (4) – use pgs 189,196, 204-
5
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23/01/10 (5)
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Explain how natural selection is responsible for the distribution of the allele for the abnormal form of
haemoglobin (HS). (5)
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Industrial Melanism in Peppered Moth
• Two forms of Biston betularia (peppered moth)
(melanic)
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Biston betularia
• Differ by only one allele of the gene forming dark pigment (melanin)
• Both forms fly by night
• Both forms rest on trees during the day
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Prior to Industrial revolution
• Pre 1800s
• Light form common throughout Britain
• Dark arose by mutation-very rare
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Light peppered moths• In non-polluted areas
-tree trunks covered with pale coloured lichens
• Moth well camouflaged against pale background
• Dark form easily seen and eaten by predators
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Survey in the 1950s• Pale form most
abundant in non-industrial areas
• Dark forms most abundant in areas suffering from heavy air-pollution
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Reason for change?• In polluted areas
-toxic gases kill lichen-soot particles darken tree trunks
• Dark coloured well hidden and favoured by natural selection
• Light coloured moth easily seen
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Frequencies of two forms of peppered moths in the 1950s
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