Kinase Inhibitors & Antibodies on Signaling Pathways

Product Information

S2394 Naringenin

Signaling Pathway: > Metabolism > P450 > P450 Inhibitors > Naringenin

Technical Data:

Biological Activity

Naringenin is a flavonoid that is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, anti-

inflammatory, carbohydrate metabolism promoter, and immune system modulator. Naringenin is the predominant flavanone in

grapefruit. This substance has also been shown to reduce oxidative damage to DNA in vitro. Naringenin found in grapefruit juice has

been shown to have an inhibitory effect on the human cytochrome P450 isoform CYP1A2, which can change pharmacokinetics in a

human (or orthologous) host of several popular agents in an adverse manner, even resulting in carcinogens of otherwise harmless

substances. [1]

References

http://en.wikipedia.org/wiki/Naringenin http://en.wikipedia.org/wiki/Naringenin ; www.scielo.br/scielo.php?script=sci_arttext&pid=S1516 www.scielo.br/scielo.php?script=sci_arttext&pid=S1516 ;

Customer Review

PLEASE KEEP THE PRODUCT UNDER -20° FOR LONG-TERM STORAGE.

NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

Specific storage and handling information for each product is indicated on the product datasheet. Most Selleck products, stored under the

recommended conditions, are stable for two years. Products are sometimes shipped at a temperature that differs from the recommended

storage temperature,most are recommended stored at -20°C. Many products are stable in the short-term at temperatures that differ from that required for long-term storage. We ensure that the product is shipped under conditions that will maintain the quality of the product,

but save your shipping charges by using the most economical storage conditons for an overnight shipment. Upon receipt of the product,

follow the storage recommendations on the product data sheet.

M.Wt: 272.25

Formula: C15H12O5

Solubility: DMSO ≥55 mg/mL Water <1 mg/mL Ethanol ≥55 mg/mL Stability: 2 years -20℃ Powder

1 week -4℃ in DMSO1 month -80℃ in DMSO

CAS No.: 480-41-1

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Datasheet of Naringenin | Selleckchem.com

2012-3-16http://69.65.43.32:8080/datasheet/naringenin-DataSheet.html