nanofasenanofase.eu/getatt.php?filename=oo_264.pdf · the nanofase exposure assessment framework...
TRANSCRIPT
Presentation Name
Name Surname
Date
What will we
build and what
will it look like?
Claus Svendsen
Kickoff Meeting Barcelona 27-29th Oct 2015
NanoF
ASE
The NanoFASE
Exposure Assessment Framework
Kickoff Meeting Barcelona
27-29th Oct 2015
Deliver better models and methods for ENM fate in the
environment:
Where, in what form and for how long?
London (UK)
Thames (UK)catchment
3) Object-oriented multimedia fate modelsdynamically connecting “Environmental cells”
Air
W
ate
r
SMPPhase
Freephase
Sedimentphase
SolidPhase
Soil
Pore waterPhase
X
Y
2) Environmental„cell“reactors
1) ENM enabledProduct value chains& release pathways
ENM Synthesis
ENM Prod. Manu.
Distribution
Use phase
Waste mgt.
GIS layers providing “cell” specific:• Human population & Industry• Elevation & river network• Vegetation, soil type & landuse• Environmental chemistryRecycling
Conceptual workflow for a framework to deliver dynamic multimedia fate prediction both in a generalised model environment and GIS enabled mode.
Focus on the “real product” and “environmentally realistic/relevant forms.
NanoF
ASE
The Scope and limitations:• Focused on Release to and Fate in the environment
• Generation of Exposure Assessment Framework
• Models and Methods for parameterising these
• Environmental Fate includes transfer to Biota
• EXCLUDED are measures of EFFECT/Hazard
• Human exposure only through the environment
• EXCLUDED are Worker and consumer exposure
NanoFASE – Scope and limitations:
Kickoff Meeting Barcelona
27-29th Oct 2015
NanoF
ASE
NanoFASE the connections:
Kickoff Meeting Barcelona
27-29th Oct 2015
NanoF
ASE
NanoFASE the connections:
Kickoff Meeting Barcelona
27-29th Oct 2015
London (UK)
Thames (UK)catchment
3) Object-oriented multimedia fate modelsdynamically connecting “Environmental cells”
Air
W
ate
r
SMPPhase
Freephase
Sedimentphase
SolidPhase
Soil
Pore waterPhase
X
Y
2) Environmental„cell“reactors
1) ENM enabledProduct value chains& release pathways
ENM Synthesis
ENM Prod. Manu.
Distribution
Use phase
Waste mgt.
GIS layers providing “cell” specific:• Human population & Industry• Elevation & river network• Vegetation, soil type & landuse• Environmental chemistryRecycling
Conceptual workflow for a framework to deliver dynamic multimedia fate prediction both in a generalised model environment and GIS enabled mode.
Focus on the “real product” and “environmentally realistic/relevant forms.
WP4
WP5
WP6
WP7
WP8
WP9
WP2
NanoF
ASE
NanoFASE – Cross cutting delivery:
Kickoff Meeting Barcelona
27-29th Oct 2015
London (UK)
Thames (UK)catchment
3) Object-oriented multimedia fate modelsdynamically connecting “Environmental cells”
Air
W
ate
r
SMPPhase
Freephase
Sedimentphase
SolidPhase
Soil
Pore waterPhase
X
Y
2) Environmental„cell“reactors
1) ENM enabledProduct value chains& release pathways
ENM Synthesis
ENM Prod. Manu.
Distribution
Use phase
Waste mgt.
GIS layers providing “cell” specific:• Human population & Industry• Elevation & river network• Vegetation, soil type & landuse• Environmental chemistryRecycling
Conceptual workflow for a framework to deliver dynamic multimedia fate prediction both in a generalised model environment and GIS enabled mode.
Focus on the “real product” and “environmentally realistic/relevant forms.
WP1:Exposure Assessment Framework for ENMsFrom here comes the “EAF” and the “FFG”
WP2:Integrated Multimedia Fate ModelFrom here comes the “Model Catalogue”
WP3:ENM Supply, characterisation, & TransformationFrom here comes the “Method Catalogue”• Exposure preparation and media• “Pristine” &“Exposure relevant” ENMs• Analytics & Characterisation• “Functional fate assays”
NanoF
ASE
NanoFASE – What will the EAF look like:
Kickoff Meeting Barcelona
27-29th Oct 2015
London (UK)
Thames (UK)catchment
3) Object-oriented multimedia fate modelsdynamically connecting “Environmental cells”
Air
W
ate
r
SMPPhase
Freephase
Sedimentphase
SolidPhase
Soil
Pore waterPhase
X
Y
2) Environmental„cell“reactors
1) ENM enabledProduct value chains& release pathways
ENM Synthesis
ENM Prod. Manu.
Distribution
Use phase
Waste mgt.
GIS layers providing “cell” specific:• Human population & Industry• Elevation & river network• Vegetation, soil type & landuse• Environmental chemistryRecycling
Conceptual workflow for a framework to deliver dynamic multimedia fate prediction both in a generalised model environment and GIS enabled mode.
Focus on the “real product” and “environmentally realistic/relevant forms.
[Fe3+L]
FeOx NP
Fe2+aqu
AsO43-
AsO43-
AsO43-
PO43-
PO43-
PO43-
NOMNOM
NOM
aggr
egat
ion
de-
aggr
egat
ion
diffusion limitedDf < ~2
reaction limitedDf > ~2
FeOx NPs emitted into waste waterfrom use in cancer therapy
Fig. 2 Likely transformations of FeOx NPs in water reactors
Methods and protocolsSummaryEnvironmentalFateNan
oFASE
NanoFASE – What will the FFGs look like:
Kickoff Meeting Barcelona
27-29th Oct 2015
London (UK)
Thames (UK)catchment
3) Object-oriented multimedia fate modelsdynamically connecting “Environmental cells”
Air
W
ate
r
SMPPhase
Freephase
Sedimentphase
SolidPhase
Soil
Pore waterPhase
X
Y
2) Environmental„cell“reactors
1) ENM enabledProduct value chains& release pathways
ENM Synthesis
ENM Prod. Manu.
Distribution
Use phase
Waste mgt.
GIS layers providing “cell” specific:• Human population & Industry• Elevation & river network• Vegetation, soil type & landuse• Environmental chemistryRecycling
Conceptual workflow for a framework to deliver dynamic multimedia fate prediction both in a generalised model environment and GIS enabled mode.
Focus on the “real product” and “environmentally realistic/relevant forms.
WWTP & Incineration Processes
The Functional Fate Groups:• Reducing complexity• Focusing on the main flows
e.g. Where 80% of the mass goese.g. Where the most reactive forms go
NanoF
ASE
How will people find all that we do?
We have to tell them, show them, and give it to
them.
We have to select the right formats
We will use the Advisory Board to guide us
They will provide direct feedback and collaboration to
the project AND the WPs
Making the work have IMPACT
Kickoff Meeting Barcelona
27-29th Oct 2015
NanoF
ASE
The Stake holder part of the AB:
Making the work have IMPACT
Kickoff Meeting Barcelona
27-29th Oct 2015
NanoF
ASE
The Academic part of the AB:
Making the work have IMPACT
Kickoff Meeting Barcelona
27-29th Oct 2015
The “Experts” will:• Link directly with selected WPs through collaboration where possible.• Advise on upcoming events where NanoFASE should be present.Nan
oFASE
Feedback from the 1st AB:
Need to create “acceptance” for a set of models to begin
populating as a community
Need spatially resolved models
Need to include chemistry in the models
Need to consider integration of models, e.g. particle number basis
or mass basis.
Need bio-uptake models
Need “groupings” for NMs and determine how we define
transformations
Need general models and assays for “screening” fate
Making the work have IMPACT
Kickoff Meeting Barcelona
27-29th Oct 2015
NanoF
ASE
NanoF
ASE