Nancy E. Lane, M.D.

Home Address: 1060 Barroilhet Avenue, Hillsborough, CA 94010 Office Addresses: Center for Musculoskeletal Health

University of California Davis Medical Center 4625 Second Avenue, Suite 2000 Sacramento, CA 95817

Telephone: (916) 734-0758 Fax: (916) 734-4773 Email: nelane@ucdavis.edu

TRAINING AND EDUCATION

Undergraduate: University of California, Davis - BS, Biochemistry, 1976 Honors: Graduated with highest honors

Department of Biochemistry Citation Phi Kappa Phi

Medical School: University of California, San Francisco - MD, 1980 Residency: Medicine, Mount Zion Hospital and Medical Center, San Francisco, CA 1980-1983 Fellowship: Clinical Fellow in Rheumatology, 1983-1985 Palo Alto Veterans Administration Hospital and Stanford University Medical Center, Stanford, CA Certification: General Medical License, 1981 G045856 and DEA AL2070605 Diplomat, American Board of Internal Medicine, 1983 Diplomat, subspecialty Board of Rheumatology, 1986

CURRENT POSITIONS

Distinguished Professor of Medicine and Rheumatology

Dean’s Endowed Chair in Aging Research Director, Center for Musculoskeletal Health Director, NIH/ORWH/BIRCWH Award PI/Director, USBJD/NIH Young Investigators Grant Writing Initiative Associate Editor: Seminars in Arthritis and Rheumatism Director, Academic Geriatric Resource Center at UC Davis

PI, NIH ORWH/NIAMS SCOR Grant: “Sex Differences in Musculoskeletal Diseases across the lifespan” Adjunct Professor, Jinan University, GuangZhou, Guangdong Province, China Affiliated Faculty, Department of Epidemiology and Biostatistics, UCSF

PREVIOUS EMPLOYMENT

2005-2011 Director, Center for Healthy Aging at UC Davis Endowed Professor of Medicine and Rheumatology at UC Davis Director, Academic Geriatric Resource Center Co-Editor: Arthritis and Rheumatism

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Co- director NIH/0WH/BIRCWH Award at UC Davis 1997-2004 Associate Professor of Medicine and Rheumatology, In Residence, University of California, San

Francisco (UCSF) 1990-1997 Faculty, Division of Rheumatology, Epidemiology and Biostatistics

UC San Francisco/San Francisco General Hospital (SFGH)

1990-2004 Attending Physician, Medicine and Rheumatology, SFGH/UCSF Attending Physician, Rheumatology Outpatient Clinic, SFGH 1992-2004 Faculty, Clinical Pharmacology Postgraduate NIH Training/UCSF 1990-2004 Faculty, Rheumatology Postgraduate NIH Training Grant 1995-1997 Associate Clinical Professor of Medicine and Rheumatology, UCSF 1990-1995 Assistant Clinical Professor of Medicine and Rheumatology, UCSF 1988-1990 Assistant Voluntary Clinical Professor of Medicine, Rheumatology, Stanford 1991-1998 Adjunct Associate Professor California College of Podiatric Medicine Rheumatology Consultant, HRSA/AIDS Education and Training Centers 1987-1990 Associate Director, Clinical Investigation, Syntex Laboratories

HONORS AND AWARDS

1984 Western Region, Merck Rheumatology Fellow Award 1992 Who's Who in American Women Affirmative Action Research Award UCSF 1992-present Numerous NIH funding awards 1996-2002 American Board of Internal Medicine, Subspecialty Board for Rheumatology 1996-97 The Best Doctors in America, Pacific Region 1997 Nominated and elected to ELAM, Executive Leadership Training for Women in Academic Medicine, Marilynn S. Singleton Scholarship for Women Leadership in Academic Medicine 1999-2005 Best 500 Doctors in the San Francisco Bay Area 2000-2003 The Best Doctors in America 1999-2003 NIH, Member Orthopedic Study Section 2001 UCSF Women in Medicine, nominated for recognition by Chancellors Advisory Committee for the

Status of Women, and Center for Gender Equity 2001-2004 American Board of Internal Medicine appointment to Osteoporosis, Practice Management

Improvement Module committee; ACR representative 2001 Top 10% Reviewers Annals of Internal Medicine 2002-present Lifetime member Strathmore's Who's Who 2004 Endowed Chair in Aging, UC Davis 2005-2007 President, Board of United States Bone and Joint Decade 2005-2010 Co-editor: Arthritis and Rheumatism 2006 Elected Association of Osteobiology Chairperson, NIAMS Centers of Excellence in MS diseases core centers 2007 Elected, co-chair Board Joint Decade Organizing Committee for 2009 USA Elected to Association of American Physicians (AAP)

Memorial Lecture, NYU University, Annual Review of Rheumatology,

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NIH Review Committees for K23 awards, KEEPS U01 on estrogen and heart disease, and R03 applications Awarded an R13 grant from NIH for USBJD Young Investigators Workshops Elected to Clinical Immunology Society 2007, Special Mentoring retreat for Rheumatology Fellows Edited Section on Metabolic Bone Disease for Current Opinion Rheumatology Elected to Internal Advisory Committee, R13 Sun Valley Hard Tissue Symposium July 2007-2009 Retained as member of DSMB for University of Indiana Program Project in Genetics of Osteoporosis International Invited Speaker for Glucocorticoid induced osteoporosis 2007, Naples, Italy Invited faculty speaker, NATURE MEDICINE Aging 2007 Bench to Bedside. Frontiers in Clinical Investigation, La Jolla, CA Finalist for Marion Spencer Fay Award established by the National Board for Women in Medicine, and Leadership Institute for Drexel University College of Medicine

Elected Advisory Board for Nature Clinical Practice Rheumatology Elected Associate Editor Arthritis Research and Therapy Honored by ASBMR for USBJD Presidency 2008 Member of Auditors Committee, AAP International Invited Speaker, OARSI Research Conference, Rome, Italy

Inducted into the San Mateo County Women’s Hall of Fame for contributions to the field of medicine, Dean’s Excellence in Scientific Mentoring Award, UCDMC Elected Advisory Board Member: Natures Reviews Rheumatology 2009 Selected by Academic Dean of Harvard Medical School to serve on an external ad hoc promotions for

two professors of medicine at Harvard Medical School Member, confidential ad hoc committee to review the accomplishments of an endowed chair,

UCDMC Nominated for Gideon Rodan Mentoring Award by ASBMR for excellence in mentoring junior faculty in their careers in academic medicine

UC Davis Chancellor’s Awards Committee Nominated Council, American Society of Bone and Mineral Research Visiting Professorship, Taiwan University, Taiwan Co- Chairperson, Bone and Joint Decade International Meeting, host USBJD, Washington DC

Elected Advisory Board Member: Natures Reviews Rheumatology 2010 Elected to Council, American Society of Bone and Mineral Research Invited Faculty, IBMS, Workshop on Osteoporosis, Davos, Switzerland

Invited to address, TREAT OA European OA investigators at Royal College of Physicians Meeting Listed by Thomas Reuters, top 5% of cited publications in biology and biochemistry

Member, organizing committee AOSSM/NIH U13 Post-injury osteoarthritis conference, II 12/5/2010, abstract selection, organizing committee and moderator. New Orleans, LA Elected Advisory Board Member: Natures Reviews Rheumatology

2011 FDA Advisory Committee, Specialist member, Arthritis, Allergy, and Immunology Section, April 1, 2011

Nominated member of Arthritis Foundation Research Strategy Committee, Western Region Representative

Arthritis Research Council, UK, junior investigator grant review committee Arthritis Research Council, UK, review of musculoskeletal institute vision

President’s Invited Speaker, Osteoporosis Committee of China Gerontological Society (OCCGS) Annual Meeting, Nanjing, China Oscar Gluck Memorial Lectureship American College of Rheumatology for outstanding work in the field of osteoporosis Rib Award, International Bone and Mineral Society, for outstanding accomplishments in the field of osteoporosis and hard tissues (award given August 2012) Awarded P50 CORT grant from NIAMS/NIH for Translational Studies of Osteoarthritis and Imaging (best score of 40 applications)

Appointed Arthritis Foundation Research Strategy Committee (National) Appointed Arthritis Foundation, Western Region, Research Committee

Abstract Selection Committee, Association of American Physicians Annual Meeting

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Elected Top 100 Scientists, International Biographical Centre Elected Advisory Board Member: Natures Reviews Rheumatology NIAMS Biospecimen Review Committee member Named Sacramento’s Best Doctors in Rheumatology

2012 Elected Master American College of Physicians Interprofessional Pain Management Competency Program Committee Member, UC Davis

Invited International Professor, Australian Rheumatism Society, Australian Orthopedic Research Society, and Australian New Zealand Osteoporosis Society. Three invited talks and visits to Western Australian Research Groups Awarded PI, California Institute of Regenerative Medicine $20 million dollar grant for translational stem cell research Awarded PI, for Office in Research in Women’s Health, SCOR project on Sex Differences in Musculoskeletal Diseases across the lifespan

Head, Abstract selection committee for EULAR for Osteoporosis, Berlin Germany Chair, NIAMS AMS Study section (2014-2016) Elected Council Member, ASBMR (2010-2013) Translational Abstract Reviewer for h annual Meeting Arthritis Foundation, Section Leader, OA Research Grant proposals 9/2012

Invited Faculty, 199th International Bone Densitometry Workshop and 26th Annual Osteoporosis Symposium, Breckenridge, Colorado

Invited International Grant Reviewer, Austrian Science Fund International Biographical Centre, Cambridge England, Top 100 Health Professionals 2011 and 2012

Invited Speaker, Bone Disease Program to Texas, MD Anderson, Houston, TX Invited Speaker, 2012 World Congress on Osteoarthritis, Barcelona, Spain “Update on NGF inhibition and OA”

Invited Faculty “Excellence in Rheumatology” Madrid, Spain Named “Best Doctors in Sacramento” Invited, Ad hoc Member of Promotions Committee for Harvard Medical School Professor Assessment IBMS/ Japanese Society for Bone and Mineral Research (JSMBR-IBMS) Abstract Review Committee

Elected Advisory Board Member: Natures Reviews Rheumatology Invited Speaker, 9th Annual Osteoporosis, New insights in Research, Diagnosis, and Clinical Care, “Estrogen,SERMS” Invited Speaker, “Osteoporosis”, University of Arkansas for Medical Sciences Chair and Speaker of Glucocorticoid-induced Osteoporosis, 42nd IBMS International Workshop in

Sun Valley: Musculoskeletal Biology, “The Epidemiology of GIOP” and Treatment of GIOP – The Science Behind it”, Sun Valley, ID Guest Editor, “Special Issue: Osteoarthritis.” Bone. Vol.51, Issue 12, August 2012 Invited Speaker, Congress on Osteoarthritis, OARSI, “Update on NGF inhibition and pain in OA”, Barcelona, Spain Invited Faculty, OARSI/ FDA Imaging Biomarkers Meeting, Hiltonhead, NC

2013 Member, Board of Scientific Counselors for NIDCR Internal Scientists Program, NIH

Invited Reviewer by the German Government for a Priority program “Immunobone-A Program to Unravel the Mutual Interactions between the Immune System and Bond” Erlangen, Germany

NIAMS, NIDCR, NIIR expert roundtable meeting on the Temporal Mandibular Joint in Health and Disease, Bethesda, MD

Invited Faculty, AAOS/NIH Bone Quality Symposium “Glucocorticoid Induced Bone Fragility” Invited Speaker, “Update on OA”, “Update on osteoporosis”, “Glucocorticoid induced osteoporosis” Puerto Rico Rheumatism Society, San Juan, Puerto Rico UC Davis School of Medicine Dean’s Science Team Award for Excellence for multidisciplinary team contributions Editorial Advisory Board, Arthritis Self-Management Member, Medscape Ob/Gyn and Women’s Health Steering Committee on “Clinical Advances in Osteoporosis” David Trentham Visiting Professor, “Glucocorticoid Induced Osteoporosis: A Translational Journey”, Speaker, Medical Grand Rounds; “Women in Medicine: Navigating an Academic Career in Medicine”,

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Beth Israel Deaconess Medical Center/Harvard Medical School Teaching Hospital; and “Update on Osteoarthritis Treatment”, Speaker, Rheumatology Grand Rounds, Boston, MA

Member, ASCI/AAP Joint Meeting Abstract Selection Committee Judge, ASCI/AAP Joint Meeting Abstract Awards for Physician Scientists in Training

Elected Advisory Board Member: Natures Reviews Rheumatology Esteemed Award Recipient, Paula Stern Achievement Award, ASBMR Invited Speaker, Fellows Conference, California Rheumatology Alliance, 9th Annual Medical

and Scientific Meeting, Santa Monica, CA Member, Nominating Committee, Osteoarthritis and Cartilage Research Society (2013-2016) Member, NIAMS, NIH 2013/10ZAR1 HL study section Member, NIDDK, NIH GRB-R-2013 Member, Institute of Medicine of the National Academies Distinguished Lecture, Bioengineering, UC Davis School of Engineering “The Wnt signaling pathway, the bones and joint connection”

Elected Scientific Advisor Committee Member: International Osteoporosis Foundation AAOS, appointed voting panel member: Appropriate Use Criteria for Non-Arthroplasty Treatment of Osteoarthritis of the knee (development of AAOS quality initiatives) 2014 Invited Speaker, 14th Bergmeyer Conference on Women’s Health, International Federation of Clinical

Chemistry and Laboratory Medicine, Grainau, Germany Ad hoc Promotion Committee for Professor of Orthopedic Surgery, Harvard Medical School Academic Forum, Department of Medicine, School of Medicine, UC Davis, for Academic Accomplishments in Research Invited Speaker, Argentine Congress of Osteoporosis, Organizing Committee of the Argentinean Osteoporosis Society, Buenos Aires, Argentina Invited Faculty, 2014 California Providers’ Best Practices & GPRA Measures Continuing Medical Education Conference and Diabetes Day, Sacramento, CA Invited Speaker, 7th International Workshop on Osteoarthritis Imaging, Reykjavik, Iceland Selected by Dean Academic Dean of Harvard Medical School to serve on an external ad hoc promotions for a promotion to professor of medicine at Harvard Medical School Invited Speaker, XXXI Congresso Brasileiro De Reumatologia SBR, Belo Horizonte, Brazil AAOS Invited Panel member Non-Arthroplasty Treatment of Osteoarthritis of the Knee. Judge, ASCI/AAP Joint Meeting Abstract Awards for Young Investigators

2015 ASCI/AAP Joint Meeting, Abstract Reviewer

Invited Expert, Chronic Inflammation and Bone Structure (CIBS) Working Group, International Osteoporosis Foundation Invited Member, California Rheumatology Alliance Advocacy Committee (2015-2017) Board Member, Scientific Advisory Committee of the CORRONA Research Foundation Top Rheumatologist in Sacramento, The Leading Physicians of the World, International Association of HealthCare Professionals Invited Editor, “Federal Research Regulations and Reporting Requirements: A New Framework for Selected Member, National Academy of Sciences Committee to review clinical studies performed by Environmental Protection Agency Appointed, Board of Scientific Counselors, NIDCR/NIH 2015-2017

2016 Inaugural recipient of the Steven Krane Award, American Society of Bone and Mineral Research Invited Speaker, OARSI, 2016 World Congress on Osteoarthritis, Amsterdam, The Netherlands

“Plenary Session 6 – Year in Review, Clinical” Moderator, “Session V: Using Big Data to Understand Joint Crosstalk” AAOS/ORS Tackling Joint

Disease by Understanding Crosstalk between Cartilage and Bone Research Symposium, Rosemont, IL Invited Mentor, Joint Meeting, AAP/ASCI/APSA, Oakland, CA, Chair, Independent Monitoring Board, “Berries and and Bone” Invited Speaker, “Plenary Session 6-Year in Review”, 2016 World Congress on Osteoarthritis,

Amsterdam, The Netherlands, Mar 31-April 3, 2016 Invited speaker, Current phase 2-3 studies in progress in knee or hip OA, AF/

OARSI symposium speaker, Atlanta, Georgia

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2017 Chair, Board of Scientific Counselors, NIDCR/NIH 2017-2019 Visiting Professor, SRM Medical College, Chennai, India. Lecture: “Update on Osteoarthritis Wnt

Signaling and Nutriceutical Treatment”. May 2017 Keynote Speaker, SRM Medical College, Chennai, India. Lecture: “Update on Osteoarthritis Wnt

Signaling and Nutriceutical Treatment”. May 2017 Invited Visiting Research Professor/Speaker, Mayo Clinic Rochester, Orthopedic Grand Rounds

“Treatment of Musculoskeletal Diseases With a Little Help From Your Own Stem Cells” and The Musculoskeletal Research Conference “An Update on GC Induced Osteoporosis”

Invited Speaker, British Society for Rheumatology Meeting, “The Regeneration Game: Effective Treatment of Osteoarthritis”

Invited Speaker, 47th ORS International Musculoskeletal Biology Workshop, “Treatment of Osteoarthritis: New Horizons Fellow of the American Association for the Advancement of Science, AAAS, Nov 2017

2018 Invited Speaker, Emory University School of Medicine, “Recent Developments in the Management of

Psoriasis and Psoriatic Arthritis: Implications for Clinical Practice.” Selected member, by The National academies of Sciences, Engineering and Medicine, as an expert

reviewer for the U.S.-Egypt Science and Technology Joint Fund.

UNIVERSITY ADMINISTRATIVE RESPONSIBILITIES UC DAVIS 2005-Present: 2005 Vice Chair for Research, Department of Medicine (2005-2009) Co-Director, BIRCWH NIH Award Internal Advisory Board, K30 Program Committee Member, Pharmacy and Therapeutics (2005-2001 Search Committee Chair, Osteoporosis Clinician Scientist (2005-2012) Member, UC Davis Cancer Center, current 2006 Member, Cell and Developmental Biology graduate group (2006-present) 2009 Member, ad hoc Dean’s office committee on review of an endowed chair Member, interviewing committee, Statistician/Assistant Professor for Department of Medicine

Chair of 2 search committees for Medicine and Epidemiology/Public Health Sciences

2010 Chancellor’s Advisory Committee on Faculty Recognition and Awards (2010-2012) Co-Instructor of Record, MCRT, Translational Journal Club

Co-Director, BIRCWH Award for Research Training in Women’s Health, NIH funded Principal Investigator/Director, Academic Geriatric Resource Center

Director, Musculoskeletal Health Member, UC Davis School of Nursing Graduate Council Co-Principal Investigator NIH, P50 CORT grant UC Davis - UCSF Director, Academic Geriatric Resource Center, UC Davis

2011 Academic Senate, Privilege and Tenure Committee member 2012 Director, Center for Musculoskeletal Health Academic Senate, Privilege and Tenure Committee member Director, Department of Medicine Mentoring Program Member, Honors and Awards Committee, School of Medicine

Member, Competency Advisory Committee, Interprofessional Pain Management Competency Program, UCD Health System Member, Graduate Group in Clinical Research Member, Graduate Group in Cell Biology

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2013 Member, Graduate Group in Clinical Research

Member, Graduate Group in Cell Biology Member, Graduate Group in Nursing Science and Health-Care Leadership Member, Davis Division Academic Senate, Privilege and Tenure Committee Judge, Interdisciplinary Graduate and Professional Student Symposium

2014 Chair, Davis Division Academic Senate, Privilege and Tenure Committee, 2014-2016 Member, University of California Academic Senate, Privilege and Tenure Committee, 2014-2017 Director for Research, NIH K12 BIRCWH 2015 Grant reviewer for W.M. Keck Foundation Science & Engineering and Medical Research Programs 2016 Vice Chair of the University of California Committee on Privilege and Tenure (UCPT), 2016-2017 2017 Chairperson, University of California Committee on Privilege and Tenure (UCPT), 2017-2018 UCSF 1990-2004: 1990-1996 SFGH Medical Records Committee 1990-2004 SFGH Pharmacy and Therapeutics Committee 1993-1997 Grant Reviewer for the University AIDS Research Grants 1993-2004 Mentor, Medical Residency Program UCSF 1995-1997 Internal Medicine Internship Selection Committee 1997-2001 School of Medicine, UCSF Admissions Committee 1994 Member, Search Committee, Department of Medicine for- Assistant Professor of Medicine,

Nephrology search 1996-1998 Member, Search Committee, Assistant Professor of Medicine and Geriatrics in Residence 1998 Member, Search Committee, Assistant Professor of Medicine and Rheumatology in Residence Committee Member, Special Grievance subcommittee for Vice chancellor, School of Medicine, UCSF 1999-2004 Toland Society, Advisory committee, UCSF School of Medicine Fundraising 1998-2004 Chair, ad hoc promotion committee, School of Medicine, UCSF 1999-2001 Subcommittee Member, Department of Medicine Promotions Committee Chairperson, 20 year UCSF Medical School Reunion Committee (Raised $65,000) 2001-2003 Academic Senate, UCSF, member Graduate Council 2001-2004 Academic Senate, UCSF, Mentoring Group 2001 Chairperson, Osteoporosis Guideline Committee, SFGH/UCSF Member, Search Committee for Department of Epidemiology and Statistics-Assistant Adjunct

Professor of Medicine 2002-2004 UCSF Graduate Student Council Fellowship sub committee

SOCIETY MEMBERSHIPS

1983-present Fellow member, American College of Rheumatology 1984-1992 Member, American College of Physicians 1984-present Northern California Arthritis Foundation 1985-present Society of Bone and Mineral Research Phi Delta Epsilon Medical Fraternity 1990-present Orthopedic Research Society

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1995-2001 Board of Directors Orthopedic Research Society 1996-present Osteoarthritis and Cartilage Research Society 1999-present SELAM (Society of Executive Leadership for Women in Academic Medicine) 2005-present Association of Osteobiology 2007-present Association of American Physicians, AAP 2010-present Fellow, American College of Physicians 2011-2014 Elected Board of Directors, American Society of Bone and Mineral Research 2012-present Master, American College of Physicians 2014-present National Academy of Medicine (previously Institute of Medicine (IOM)) 2015- present Council of Scientific Advisors, elected International Osteoporosis Foundation (IOF) 2017 American Clinical & Climatological Association

EDITORIAL BOARDS FOR JOURNALS

1995-present Editorial Board, The Journal of Clinical Rheumatology 1997-present Editorial Board, The Journal of Musculoskeletal Medicine 1998-2003 Editorial Board, Arthritis and Rheumatism 1998-present Editorial Board, The Journal of Rheumatology 1999-present Editorial Board, Osteoporosis International Editorial Board, Arthritis Research Editorial Board, Arthritis Self-Management 1999-2002 Section Editor, Yearbook of Rheumatology, Arthritis and Musculoskeletal Diseases 1999-2001 Section Editor, Osteoporosis, Current Rheumatology Reports 2002-2006 Associate Editor, Primer of Metabolic Bone Diseases 2004-2010 Editorial Board, Journal of Bone and Mineral Research 2005-2010 Co- Editor, Arthritis and Rheumatism 2008-2015 2008-2015 Associate Editor, Arthritis Research and Care Editorial Board, Faculty of 1000 Medicine 2008-present Editorial Board, Nature Reviews Rheumatology 2010-present Associate Editor, Seminars in Arthritis and Rheumatism Editorial Board, Journal Rheumatology (OXFORD) 2011-present Consultant Reviewer, New England Journal of Medicine 2011-2016 Associate Editor, Rheumatology, British Society for Rheumatology 2013-present Editorial Board, Rheumatology Network 2013-2016 Editorial Board Clinical Rheumatology Editorial Board, Journal of Orthopedic Research 2014-present Consultant Reviewer, Kidney International 2015-present Editorial Board, Journal of Rheumatic Diseases and Treatment 2018 Editorial Board, Advances in Geriatric Medicine and Research.

OTHER ACTIVITIES

Consultant Reviewer: 1990-1995 Journal of Rheumatology 1990-present Journal of the American Medical Association

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1994-present Journal of Bone and Mineral Research 1991-1998 Arthritis and Rheumatism 1992-present Journal of Orthopedic Research 1993-present Annals of Internal Medicine 1995-present Osteoarthritis and Cartilage 1997-present Arthritis Care and Research 1994-1997 Invited Editor: Yearbook of Rheumatology 1994-present Journal of Clinical Rheumatology 1995-present Annals of the Rheumatic Diseases Journal of Bone and Joint Surgery Journal of Clinical Investigation 1996-present Journal of the Geriatrics Society 2005-present New England Journal of Medicine 2013-present NIAMS: long-range plan for fiscal year 2010-2014 2014-present Journal of American Aging Association 2015-present Stem Cell and Development Stem Cell Research and Therapy

PEER REVIEW STUDY SECTIONS (Selected)

1989-1995 Member Abstract Selection Committee National Meeting 1990 Ad hoc NIH site visit member for the GCRC University of Texas, Houston 1992-present Ad hoc Merit Grant Reviewer, Veterans Administration 1993-1994 Member of study section, American Institute of Biological Sciences, NASA Counter measures to

prevent bone and soft tissues in space 1993-2004 Scientific Peer Reviewer, Canadian Arthritis Foundation 1993 Grant Reviewer, University AIDS Clinical Research Centers 1994-2014 NIAMS Study section member to Review Clinical Trial Grant Applications Scientific Advisory Board Member, NASA for Human Research Facility in Space 1994-1997 Scientific Advisory Board, Rheumatology Research International 1994-2003 External Grant Reviewer, Arthritis and Rheumatism Council for Canada for career development

awards 1995, 1996 External Grant Reviewer-Arthritis and Rheumatism Council for Great Britain and the Commonwealth

for career development awards 1995 External reviewer, NIH/MAC grant, Northwestern University Scientific Reviewer, Canadian Council for Arthritis Research 1996 External reviewer, Department of Defense, Osteoporosis 1996-2000 Peer Review Consultant, UIS/DOD Scientific and Biomedical Consultant 1997 P01 for Diabetes Mellitus Interdisciplinary Research Projects Peer Reviewer, NIAMS- SCORE grants in Osteoporosis Ad hoc reviewer, NIH/NIAMS orthopedic study section Consensus panel member, NIH/NIAMS on the genetics of OA 1998 Ad hoc study section, NIH/NIAMS on clinical trials in osteoporosis 1998-2001 NIH/NIAMS Orthopedic Study section, ad hoc member 2001-2003 NIH/NIAMS Orthopedic Study section, member approval

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2001 Reviewer, NIH/NIAMS-Centers for Study of Musculoskeletal Diseases Welcome Trust Research grants for United Kingdom 2002 Independent Review Panel, Abbott Scholar Award in Rheumatology Research 2003 NIH Chairperson, Ad hoc Study Section, Review of GC osteoporosis in children, NIAMS 2005 Chair, NIAMS Special study section on P30 Centers of Excellence MS Diseases 2006 NIH Special Study section, NIAMS R03 application reviewer 2007 NIH/NIAMS Special Study section Reviewer KEEP, Program Project Peer Reviewer, Genetics of Osteoarthritis, ARC Grant, UK 2008 External Reviewer, Quinquennial Scientific Review Kennedy Institute of Rheumatology, London, UK NIH Peer Review for NIAMS, Program in Load Repayment Grants NIH Peer Review K23 Applications for NIAMS 2009 Peer Reviewer for internal funding for Women’s Health Research Grants at Yale University School of

Medicine NIH/NIAMS ad hoc Study Section, NIA for R01s review—ZAG ZIJ-4 M@ Biochemical risk Markers

(Harman PI) NIH/NIAMS ad hoc Study Section Reviewer for NIH Stimulus Package GO AWARDS Bethesda, MD

2010 VAH/DOD review panel 2012 NIH ad hoc Grant Reviewer, Center for Scientific Review

Member, NIAMS AMS Study section (2012-2016) including chair 2014-2016

2013 Austrian Science Fund (FWF) Proposal Reviewer for clinical research funding in Austria 2015 Peer Reviewer for Arthritis Research UK – Scientific Review 2016 Peer Reviewer, Agency for Healthcare Research and Quality (AHRQ) Effective Health Care (EHC)

Program 2017 Peer Reviewer, NBA & GE Orthopedics and Sports Medicine Collaboration 2018 Abstract Reviewer, Abstracts for OARSI National Meeting

External Reviewer, U.S.-Egypt Science and Technology Joint Fund, Cycle 19, National Academies of Sciences, Engineering, and Medicine. Expert Reviewer (EPC) for AHRQ review of osteoporosis treatment.

NIH RELATED ACTIVITIES

1999 Moderator, Session on Systemic Factors in the Prevention of Osteoarthritis. In NIAMS sponsored workshop on “Stepping Away from Osteoarthritis”

Invited speaker, “Bone mineral Density and osteoarthritis: Session on Systemic Factors in the prevention of Osteoarthritis.” In NIAMS sponsored workshop “Stepping Away from Osteoarthritis”

Invited speaker: DOE/NIAMS meeting “Musculoskeletal imaging for the next millennium” 2000 Invited speaker: NIAMS/NIH Osteoporosis Consensus Conference, “Glucocorticoid and inflammatory

induced osteoporosis” Invited speaker and moderator, Interpretation of the impact of anti- rheumatic therapies on

radiographic progression of rheumatoid arthritis, NIH/NIAMS Conference 2003 Invited attendee, NIH/NIAMS Roundtable with Dr Katz on the Bone Diseases Roundtable 2004-2010 DSMB member for R01AG18397 PI- Dr. Michael Econs, University of Indiana, Indianapolis 2005 NIH/NIAMS Co-Chairperson, NIH and U.S. Bone and Joint Decade meeting—Update on Progress

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NIH Special Advisory Roundtables for NIAMS on Genetics and Research Career paths in Rheumatology Training to the Director of NIAMS, Stephen Katz, MD

2005-2010 External Advisory Committee for NIH/NIAMS Center for Translational Research (CORT) for University

of Rochester 2008 Task force for Secretary Michael O. Leavitt for The President’s Council on Physical Fitness and Sports

and the Office of Disease Prevention and Health Promotion on “The Physical Activity Guidelines for Americans” 3/2008 to 8/2008. Guidelines presented to the public on October 7, 2008

2009 Invited Speaker on “Novel Aspects of the UC Davis BIRCWH program” for Annual BIRCWH/K12

Directors Meeting, Bethesda, Maryland 2010-2011 Ad hoc special emphasis panel, Arthritis and Connective Tissue and Skin ZRG1 MMOSS-G 02M Small Grants Reviewer, R03 EHB M1-2

Abstract Reviewer for NIH/SF Bay Area Clinical Research Symposium NIAMS, P50 CORT Reviews

2012 NIAMS AMS Study Section Member (2012-2016) NIAMS, Epidemiology Review section, ad hoc member 2013 NIAMS, Co-Chair, NIH Study Section, Washington, DC - Core Centers for Musculoskeletal Biology and Medicine P30 Review Panel NIAMS, Consultant for NIAMS long-range plan for fiscal year 2010-2014 Invited Member of Scientific Community review, NIAMS Bone Biology Strategic Plan Ad hoc review, NIH/Diabetes and Digestive and Kidney Diseases, NIH ZDK1 GRB-R (O2) 2013-2016 NIH Study Section, AMSC member review 2013/10 ZAR1 HL (M1) 2014-2017 Member, Board of Scientific Advisors, NIDCR, Internal Science Program 2017-2018 Chair, Board of Scientific Advisor, NIDCR Internal Science Program 2017-2020 Grant Reviewer NIH/NCATS, Repurposing of Drugs for Rare Diseases Grant Reviewer for RFA-TR-17-001 Chair, DMC NIH funded Study; Berry’s & Bone, Connie Weaver External Advisory Board, NYU Rheumatology T32 External Advisory Board, UCSD, T 32 in Rheumatology/Immunology Grant Reviewer, NIH/ Special Emphasis panel Chairperson, Sjogren’s Syndrome Working Group, NIDCR, August 2018

AMERICAN COLLEGE OF RHEUMATOLOGY ACTIVITIES

1990-present Local media representative for ACR related 1991-1993 Member of Office, Arthroscopy Steering Committee 1992-1993 Chair, Committee on Clinical Trials for Office Arthroscopy 1992-1994 Committee member, Reporting forms for Office Arthroscopy activities 1993-1996 Communications and Marketing Committee 1993 Chairperson, Podium Presentation on Osteoarthritis, San Antonio, TX Moderator for Press Conference on “Exercise and Arthritis” ACR 53rd Meeting, San Antonio, TX 1993-1996 Editorial Board, ACR News 1993-1996 ACR Public Forum Committee 1995-1998 Western Region ACR Council 1995 Moderator for plenary session, 59th Annual ACR meeting "Osteoporosis and steroids", San Francisco,

CA

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1996 Ad hoc ACR committee to write guidelines for the diagnosis and management of steroid osteoporosis 1995-1996 Committee on Scientific Programs 1995-2006 Mentor, Summer Science Fellowship Program, Arthritis Foundation 1996-1998 Professional Meetings Education Committee 1998-2001 ACR committee on Education Chairperson, Subcommittee on CME membership surveys 1998-2002 Chairperson, Abstract selection committee on Bone metabolism and Osteoporosis (co-chair 2000-2002) 2000 Moderator for annual ACR meeting, Clinical Osteoporosis 2001 Moderator for annual ACR meeting, Anabolic Agents for Osteoporosis ACR special Abstract Selection Committee, Late Breaking Abstracts ACR representative to ACP/ASIM for review of Physician, Information Education Resource of

Amyloidosis 2002 ACR 2002 Annual Meeting Responsibilities: Meet the Professor for Osteoporosis Session; Moderator,

Scientific Concurrent Mini-Symposium on Inflammatory Bone Loss; Invited Speaker, Study Group on Immune Mediated Bone Loss; Invited Speaker, Symposium on "Bone as a Target for Lupus Damage", New Orleans, LA

2003 Invited Speaker, Spring ACR Meeting, Chicago, IL "An update on Osteoporosis" 2003-2006 ACR/REF: Grants and Awards Committee, member 2003-2005 Research and Education Foundation Scientific Advisory Committee Council committee to assess if glucosamine could prevent incident OA 2006 Geriatric Rheumatology/Gerorheumatology International Group Invited Speaker, ACR meeting, Symposium on How osteoporosis medications work, Invited Speaker, ACR annual meeting “Osteoporosis “ 2007 Mentor for REF ACR Medical Student Research Preceptorship Award Member of Abstract Selection Committee for 2007 annual meeting

Invited Symposium Speaker ACR 2007 annual meeting on “Interpreting DXA measurements” Invited Faculty, Update on Arthritis Treatment, Maryland Arthritis Foundation meeting, Cambridge, MD

Invited Speaker, Geriatric Rheumatology Emphasis group at ACR “Sarcopenia and Osteopenia” 2008 Invited Faculty, ACR Winter Rheumatology Meeting, Osteoporosis and Osteoarthritis Update,

Snowmass Invited Faculty, ACR Spring Rheumatology Meeting “Osteonecrosis and Osteoporosis”, Chicago Invited Faculty, ACR Annual Meeting, “Curbside Consults on Osteoporosis Cases” San Francisco, CA Invited Faculty, ACR Annual Meeting “How biologic agents influence bone” Osteoporosis Study Group, San Francisco, CA Special HOTLINE author “WHO, Risk factor Index” Grant Reviewer, Post-doctoral Scholar Grant for the Arthritis Foundation

2009-2010 Chair, Abstract Selection Committee for Osteoporosis and Bone Biology Scientific Category for ACR Annual Meeting

ACR representative to EULAR committee for recommendations for the prevention and treatment of osteoporosis associated with inflammatory musculoskeletal conditions Speaker, SLE Study Group, “Vitamin D and the musculoskeletal system” Speaker, OA genetics Study Group “FRZB polymorphisms, the bone and joint connection” Speaker Tour Guide, ACR posters “Osteoporosis”

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2010 Invited Speaker, ACR Board Review Course “Osteoporosis Update”, Baltimore, MD

ACR/EULAR abstract selection subcommittee co-chair for “Osteoporosis and metabolic bone disease” Rome, Italy annual meeting Invited Faculty, Department of Rheumatology, Grand Rounds Speaker: - “Update on osteoporosis and osteoarthritis”, University of Utah - “Update on osteoporosis and osteoarthritis”, University of Oregon - “Update on Treatment of Pain for OA” ACR Invited Grand Rounds Speaker “Wnt Signaling the Bone and Joint Connection”, UCSF Orthopedic Grand Rounds

2011 Invited Speaker “Complications of Bisphosphonates” and “Thoughts on an Academic Career”, ACR Spring Meeting ACR/Pfizer Fellowship Review Committee Arthritis Foundation-Research Strategy Committee, Western Region Representative

2012 ACR Annual Meeting, Washington DC: - Meet the Professor session, “Vitamin D and Health” - Invited Speaker and Moderator, “Osteoporosis, who to treat, with what and how long” - Invited Speaker, Poster Tour “Osteoporosis Abstracts”

2013 ACR Annual Meeting, San Diego, CA - Meet the Professor session, “Vitamin D and Health” 2014 ACR annual Meeting Boston, MA - Meet the Professor Session “Vitamin D and Health” Metabolic Bone Disease for CARE 2015, content expert 2015 ACR/ARHP Annual Meeting, San Francisco, CA,

- Invited Speaker, “Issues in Osteoarthritis – Public Health” Invited Member of Voting Panel, ACR GIOP Guideline Project

2016-2017 ACR representative to, Hip OA AUC Writing Panel, Department of Research, Quality, & Scientific Affairs. American Academy of Orthopaedic Surgeons, March 2017

2017 ACR/ARHP Annual Meeting, San Diego, CA, -Invited Speaker, Meet the Professor “Difficult Osteoporosis” -Invited Speaker, “Osteoporosis Management”, Meet the Professor 2018-2020 ACR Annual Meeting, Scientific Program Committee Elearning subcommittee, ARHP/ACR Meet the Professor, Annual Meeting, “Cases in Osteoporosis”

NATIONAL ACADEMY OF MEDICINE/SCIENCE AND ENGINEERING

2015 -External Review of “Public Health Dimensions of Cognitive Aging, External Reviewer -Member, Committee on Assessing Toxicologic Risks to Human Subjects used in Controlled Exposure Studies of Environmental Pollutants - Invited Editor, “Federal Research Regulations and Reporting Requirements: A New Framework for Research Universities in the 21st Century”, National Academies of Sciences, Engineering, and Medicine, August 2015

2017 Member, Committee to Review NASA’s Evidence Report on Human Health Risks, April 2017 2018 Report Review: Gulf War Health Problems

Selected member, by The National academies of Sciences, Engineering and Medicine, as an expert reviewer for the U.S.-Egypt Science and Technology Joint Fund.

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ORTHOPAEDIC RESEARCH SOCIETY

1995-1997 Board of Directors, as Newsletter member 1997 Scientific Session Moderator, National Meeting for Osteoporosis, San Francisco, CA 1998-2001 Board of Directors, Member-at-Large 1999 Invited Speaker, Annual Meeting ORS, Academic Medicine and Mentors, Anaheim, CA 2001 Moderator for annual ORS meeting Osteoporosis Scientific Session, San Francisco, CA 2004 Subcommittee on Grant Writing: Conference on Grant Writing, Orlando, FL 2004-2005 Invited Speaker, Orthopedic Research Society, Annual Meeting, “Grant Writing: The process” 2013 Invited Speaker, AAOS/ORS Bone Quality and Fracture Prevention Research Symposium, Rosemont, IL,

speaker “Effects of Glucocorticoids on Bone Material Properties” Moderator, “Session VI: Human Disease Models of Altered Bone Quality,” AAOS/ORS Bone Quality

and Fracture Prevention Research Symposium, Rosemont, IL

OSTEOARTHRITIS AND CARTILAGE RESEARCH SOCIETY

2008 Member Abstract Selection Committee for 2008 International Meeting Member of the Editorial Board, for Journal Osteoarthritis and Cartilage

Invited International Speaker for Annual Meeting “Hip geometry and risk of OA” Rome, Italy 2009 Member of OARSI/FDA initiative for guidelines for the development of medications for OA. Defining

Disease subcommittee Member, Organizing Committee, NIH/OARSI OA Biomarker Global Initiative: Biochemical Biomarker: Validation and Clinical Studies, Bethesda, MD

2010 Group Leader, FDA-OARSI initiative on Defining Disease State of Osteoarthritis 2011 OARSI/ FDA Biomarkers working group 2017 Annual meeting, abstract selection committee for New therapies 2018 Annual meeting, abstract selection committee for New Therapies 2015-present Editorial Board, Osteoarthritis and Cartilage

DECADE OF BONE AND JOINT COMMITTEE INVOLVEMENT

2003-present Decade of the Bone and Joint Research Committee Member Chairperson, Young Clinical Investigator Development Subcommittee of USBJD Research Committee 2005-present Chairperson, Young Clinical Investigator Workshop to train junior faculty to write competitive

research proposals in musculoskeletal disease 2005- 2007 President of the Board, US representative and invited speaker, International Bone/Joint Meeting 2006 US Delegate, International BJD, Ottawa, Canada Awarded BJD service award for Young Clinical Investigator workshop initiative 2007 Co-sponsor, organizing committee “Burden of Musculoskeletal diseases” publication for USBJD Past President for USBJD, executive committee 2008 Co-Chair, International BJD meeting, Washington DC 2009 Chair, Nominating Committee, USBJD Executive Board Chair, Young Investigators Research Workshop” 2010-2018 Chair of Young Investigators Research Workshop, NIH/USBJD sponsored

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AMERICAN SOCIETY OF BONE AND MINERAL RESEARCH ACTIVITIES

1994 Moderator for plenary session at annual meeting “Osteoporosis, pathophysiology”, Kansas City, KS 1995-present Member, in vivo Bone Research Group 1999 Member, Fellowship subcommittee 2000-2003 Member, Abstract Selection Committee for Osteoporosis Treatment, Scientific meeting ASBMR 2000 Moderator, Major Scientific Plenary Session on Osteoporosis Treatment, World Congress on

Osteoporosis, Chicago, IL Invited Speaker, in vivo Working Group Meeting, “Inflammatory Arthritis: From the bench to bedside”,

Toronto, Canada 2001 Meet the Professor Lecture, 23rd ASBMR meeting, "Osteoporosis in the Rheumatic Diseases",

Phoenix, AZ 2002 Co-Moderator, Plenary Symposium: Osteoporosis and Inflammation, ACR/ASBMR, Co-sponsored

symposium, San Antonio, TX 2002-05 ASBMR Science Policy Committee, ad hoc member 2002; full member 2003 Associate Editor, Primer of Metabolic Bone Diseases, 5th edition 2002-07 Abstract Selection Committee Annual Meeting 2003 Full member ASBMR Science Policy Committee ASBMR/IBMS Member of Scientific Committee and Abstract Reviewer for Joint meeting of IBMS and Japanese (JSBMR) 2003-2005 Symposium Speaker: “Grant Writing: Tips on what to do and what not to do,” ASBMR Annual Meeting,

Minneapolis, MN 2004 Mentorship Award Task Force 2005 Clinical Symposium Speaker, “Inflammatory Induced Bone Loss” Symposium on obtaining a clinical research grant 2006 ASBMR annual Meeting, Invited Speaker for Working Group in rheumatic diseases, “Inflammation and

bone loss”, Philadelphia, PA 2007 ASBMR annual meeting abstract selection committee Special task force to review Harold Frost Young Investigators Awards for scientific meeting Moderator, Scientific Plenary Sessions, ASBMR Annual Meeting, Honolulu, Hawaii 2008 ASBMR Moderator for Scientific Session on “SERMS: today and tomorrow”, ASBMR Annual Meeting,

Montreal, CA ASBMR, Abstract Selection Committee co-chair for osteoporosis: translational abstracts, ASBMR annual meeting, Montreal, CA Appointed committee to develop a national action plan for bone health, co-sponsored by NIH/NOF/ASBMR, Washington DC

2009 ASBMR annual meeting, Invited Podium Speaker, Glucocorticoid-induced osteoporosis Nominated for Gideon Rodan Mentoring Award Nominated for Council position, ASBMR Re-appointed ASBMR representative to US Bone and Joint Decade Executive Committee 2010 Elected Councilor, ASBMR

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Moderator Scientific Session, “How osteoporosis treatment work” ASBMR annual meeting, Toronto, Canada Invited Speaker, “Wnt Signaling, the bone and joint connection”, ASBMR/Rheumatology Working Group, Toronto, Canada

2011 Council member representative, ASBMR: - Women in Bone and Mineral Research Committee - Science Policy Committee, ASBMR

2012 Invited Moderator Plenary Session on “Vitamin D, the IOM report” Annual ASBMR Meeting, Minneapolis, MN Council member of the Education Committee Young Investigators mentor for ASBMR 2013 ASBMR Annual Meeting, Baltimore

- Invited Speaker, “Effects of Inflammation in Bone” - Invited Speaker, “FGF23: Emerging Concepts and Controversies”

-ASBMR Annual Meeting, Success in Research: Leadership Lessons form 2013 Esteemed Awardees, Baltimore.

- Reviewer, Grant Writing Workshop 2014 ASBMR Annual Meeting, Houston, Texas - Abstract reviewer, Osteoarthritis and Cartilage ASBMR-ORS Task Force on Cell-Based Therapies 2014-2016 ASBMR GAP Award Reviewer ASBMR Annual Meeting, Houston, TX

- Invited Speaker, “Novel Approaches for the Prevention and Treatment of Inflammatory Bone Loss”

- Mentor, Networking Breakfast - Invited Panel Member, Speed Networking Event

ASBMR-ORS Task Force on Cell-Based Therapies, Section Leader, Oct. 2014-Dec. 2015 2015 Nominated to run for President-Elect ASBMR Annual Meeting, Seattle WA

- Mentor, New Investigator Meeting - Discussion Leader, “Granting Writing Workshop: How to Connect Your Specific Aims to Your

Hypothesis” - Mentor, Networking Breakfast - Poster Tour Leader for Clinical Osteoporosis

2016 Invited Member, 2016 ASBMR Esteemed Awards Committee Invited Section Leader for Abstracts for Osteoarthritis and Cartilage Annual Meeting, Scientific Abstract reviewer for Inflammatory Arthritis Category 2018- Co-Chair Pre-Meeting, Osteoarthritis, Annual Meeting Invited Chair, Session on Treatments for Osteoarthritis Annual Meeting, scientific abstract reviewer for Inflammatory Arthritis Category

VOLUNTEER WORK

1988-2004 Medical Director and member of Board of Directors for Lair of the Golden Bear, University of

California at Berkeley Alumni Camp 1994 Volunteer Science Teacher, Hillsborough City Schools (5th and 6th grades) Volunteer Crocker Middle School Track Coach 1996 Committee for Community Service, Crystal Springs Uplands School

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1997 Crystal Springs Uplands School, Team Captain annual fundraising drive 1997 Scientific Advisory Board, Duke Center for Living 1998 Crystal Springs Uplands School, 12th grade class parent 2000 Committee lecture “Living with Arthritis” St. Andrews Church, Daly City, CA 1996-2002 Parent Volunteer, Boy Scout Troop 156, Burlingame, CA 2002 Community lecture Wellness Center, Mills Peninsula Hospital, "Men and Osteoporosis: What you

should know” 2000-2005 Board of Directors, Northern California Arthritis Foundation 2002-2005 Co-President Mothers Club, Zeta Phi Fraternity, Berkeley, CA 2007-2009 Current Member of Chancel Choir, Congregational Church of San Mateo Spokesperson for the Almond Board of California, Issues Management

SELECTED UNIVERSITY or CME LECTURES INCLUDING INTERNATIONAL INVITATION

1985 American Medical Joggers Association, Boston, MA 1987 Women and Aging Lecture Series, UC Berkeley 1988 Women and Aging Lecture Series, Osteoarthritis, UC Berkeley Humana Hospital, CME Series Arthritis Days - Arthritis Foundation Sponsored, Boise, Idaho KQED TV Health Matters, “Osteoporosis” 1989 Winter Rheumatology Symposium, Snowmass 1989 KGO Radio 610 - Invited Speaker for Arthritis Awareness Week, “Diet, Exercise and Arthritis” 1990 Hard Tissue Seminar Workshop, Sun Valley, ID 1991 KQED TV Health Matters, “Osteoporosis Update”

Northern California Quarterly Meeting of Family Physicians, “The effects of NSAIDs on bone and cartilage metabolism” Northern California Arthritis Foundation, Quarterly Meeting, Invited Speaker, “Can NSAIDs prevent bone and cartilage destruction?” KGO Radio 910, Invited Speaker, “Osteoporosis and Osteoarthritis” Medical Grand Rounds, “Osteoarthritis, Dispelling the Myths,” San Francisco General Hospital UCLA Primary Conference, Orthopedics and Rheumatology for the Primary Care Physician, Invited Speaker, “NSAIDs - Practical Guidelines for their Use in Clinical Practice,” Anaheim, CA

1991 UCLA Rheumatology Research Seminar, “Osteoarthritis pathogenesis and future treatment strategies,” Los Angeles, CA

1992 University of Utah, Div. of Rheumatology, Research Seminar, “Osteoarthritis and future treatment

interventions” UC Davis, Grand Rounds Obstetrics and Gynecology and Primary Care, “Osteoporosis” Hennipin County Hospital, Grand Rounds Rheumatology, “Osteoarthritis and the effect of exercise”

Stanford Linear Accerator Users Group, “A Novel, noninvasive, three-dimensional histomorphometry using X-ray tomographic microscopy”

1993 ACR Winter Rheumatology Symposium “Osteoarthritis” and “Strategies to combat osteopenia” ACR Office Arthroscopy Update, Western and Central ACR meeting, Denver, CO

Visiting Professor of Medicine, Loma Linda University, Grand Rounds, “Special Problems of the Female Athlete”

Visiting Professor, Family Practice Program Riverside General Hospital, Grand Rounds, “Special Problems of the Female Athlete”

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Visiting Professor, Division of Rheumatology, Stanford, Grand Rounds, “The Rheumatic Manifestations of HIV” UCSF Outreach Program, Delta Memorial Hospital, Antioch CA, Grand Rounds, “Glucocorticoid-Induced Osteoporosis” Visiting Professor, Doctors Medical Hospital, Modesto, CA, Grand Rounds, “Estrogen replacement therapy, osteoporosis and today’s women” Visiting Professor, New Jersey Medical School, Newark, NJ, Rheumatology Grand Rounds, “Musculoskeletal problems of the female athlete” Visiting Professor, Medical Grand Rounds at East Orange VAH, Orange, NJ, “Osteoporosis, a disease of bone fragility” Visiting Professor, Medical Grand Rounds, St. Barnabas Hospital, Livingston, NJ, “Osteoporosis” Visiting Professor, Medical Grand Rounds, Beth Israel Hospital, Newark, NJ, “Osteoporosis, a disease of trabecular microarchitecture”

Invited Faculty: - “NSAIDs and osteoarthritis”, University of Louisiana CME, Rheumatology Update - “Osteoporosis in the 75 year old women”, UCSF/Mt. Zion Center for Aging, CME - “Exercise, what role in OA”, Case Western Reserve and Cleveland Clinic sponsored, Rheumatology - “Exercise: A cause of osteoarthritis”, 3rd International symposium on Osteoarthritis: Challenges for the 21st Century, Montreal, Canada Visiting Professor, “Recreational sports injuries, Diagnosis and Management”, Valley Community Hospital, San Maria, CA

1994 Invited Moderator for session “Epidemiology: Modifiable Risk Factors for OA,” at 3rd International symposium on Osteoarthritis: Challenges for the 21st Century, Montreal, Canada Visiting Professor, UCLA Division of Rheumatology, Grand Rounds Speaker, “Osteoarthritis of the hip in Elderly Women" Visiting Professor, Division of Epidemiology, UCSD Medical School "Osteoarthritis of the hip, risk factors and associations with BMD" Visiting Professor (CME), San Diego Arthritis Society "Steroid Induced Osteoporosis, pathogenesis and appropriate interventions"

1995 Invited Speaker, “Steroids in RA: sometimes yes” Regional ACR meeting, Seattle, WA Invited Faculty “Steroid-Induced Osteoporosis” Regional ACR meeting, Seattle, WA

Invited Speaker, “Practice Guideline Algorithms for the treatment of Rheumatoid Arthritis and Osteoarthritis” Grand Rounds, SFGH/UCSF: “The treatment of rheumatoid arthritis, what the primary care provider must know”

Visiting Professor, Medical Grand Rounds: “The appropriate use of steroids in rheumatoid arthritis” Visiting Professor, Medical Grand Rounds UCLA/Cedars Sinai Hospital “Osteoporosis” Visiting Professor, University of Utah, CME "Osteoporosis, treatment options" 1996 Visiting Professor University of Washington, Division of Rheumatology Visiting Professor, University of Iowa, Division of Rheumatology "Steroid-osteoporosis"

Faculty, Advances in Internal Medicine, "Osteoporosis-diagnosis and treatment" University of California at San Francisco, San Francisco, CA Visiting Professor, Travis Airforce Base, Medical Grand Rounds "Osteoporosis, diagnosis and treatment" Invited Speaker, Transplantation Surgery Grand Rounds “Steroid induced osteoporosis: how to prevent and reverse this disease" UC San Francisco

1997 Invited Speaker, Southern California Arthritis Foundation Scientific meeting, “Estrogen and osteoarthritis and pain management", Los Angeles, CA Invited Faculty and Moderator, American Academy of Allergy, Asthma and Immunology, (AAAI/AAI/CIS) "Steroid osteoporosis, prevention and treatment"

Invited Speaker, "Steroid osteoporosis", Western Regional ACR meeting, San Diego, CA Visiting Professor, University of Cincinnati, Medical Grand Rounds "Osteoporosis, Update" and Rheumatology Grand Rounds "How to navigate rheumatology with managed care"

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Visiting Professor, Case Western Reserve University, "Osteoporosis and other metabolic bone diseases" Visiting Professor UC San Diego, - "What is an anabolic agent for osteoporosis", (Endocrinology Grand Rounds) - "Steroid Osteoporosis: Prevention and treatment” Invited Lecturer, Geriatrics and Rheumatology NIA- Hartford Foundation Conference, "The Treatment of Osteoporosis in the elderly" British Columbia, Canada ACR, invited speaker, Update on Selective estrogen receptor antagonists, Washington DC

ACR Annual Meeting post-symposium, "The Treatment of steroid-induced bone loss" Washington DC 1998 Invited Faculty, 4th UCSF Seminar in Osteoporosis and Bone Biology, "Can PTH reverse steroid-

induced osteoporosis?" San Francisco, CA Invited Faculty, Keystone Symposium on the Pathogenesis of Rheumatoid Arthritis: Implications for future therapy. "Therapeutic approaches to reverse bone loss in rheumatoid arthritis."Tamarron, CO Visiting Professor, University of Minnesota, Medical Grand Rounds" Prevention and treatment of steroid-induced osteoporosis" Visiting Professor, Hospital for Special Surgery, Rheumatology Grand Rounds “Glucocorticoid-induced osteoporosis” Visiting Professor, Hospital for Joint Diseases, NYU, Rheumatology Grand Rounds “Glucocorticoid-induced Osteoporosis”

1999 Visiting Professor, University of Tennessee Memphis, Medical Grand Rounds “Glucocorticoid-induced Osteoporosis"

1999 Visiting Professor, New York University, Advanced Seminar in Rheumatology “Osteoporosis: The

science, the therapy" Visiting Professor, Columbia University, Division of Endocrinology, Grand Rounds “Glucocorticoid-

induced osteoporosis" Visiting Professor, Florida Society of Rheumatology “Osteoarthritis and osteoporosis updates” Visiting Professor, Vanderbilt School of Medicine, “Osteoporosis, an update” 2000 Invited Guest Speaker, American Academy of Dermatology, session “Dermatologic Issues of Aging and

Women,” topic “Glucocorticoid-induced osteoporosis, prevention and treatment,” San Francisco, CA Visiting Professor, UCLA, Division of Rheumatology, lecture" Trials in Osteoarthritis" Faculty, Sun Valley Hard Tissue Symposium, University of Utah, "Glucocorticoid osteoporosis treated

with PTH" 2001 Visiting Professor, Department of Medicine, Case Western Reserve University, Cleveland, Ohio,

lecture on "Osteoporosis" Invited Faculty, Global Medical Conference on Osteoporosis, "Treatment of glucocorticoid-induced osteoporosis" Madrid, Spain

2nd Annual Charles Tourtelloutte Lecture on Osteoporosis, Temple University Department of Medicine

2002 Invited Speaker, UCSF Update in Endocrinology and Metabolism, “Parathyroid hormone effects and

clinical use" Invited Faculty, NYU Rheumatology Update, "Osteoporosis Treatment by a new Paradigm", New York, NY Division of Rheumatology, Yale Medical School, Update in Rheumatology, "New treatments for Osteoporosis” New Haven, CT International Society for Rheumatic Therapy 8th Biennial Congress, "Mechanisms and Treatments for Inflammatory Bone Loss in Rheumatic Disease Patients", Washington, DC Invited Visiting Professor University of Alabama, Birmingham, for Medical Grand Rounds "Treatment of Osteoporosis with an anabolic agent", Rheumatology Grand Rounds “Osteoporosis is a disease that is immune mediated", Bone Research Group “Are statins bone active agents?"

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2003 Invited Visiting Professor, University of North Carolina, Chapel Hill, Medical Grand Rounds "Update on Osteoporosis treatment", Annual Conference for Internal Medicine update, "Osteoporosis, treatment with a new paradigm" Invited Visiting Professor, University of Colorado, Denver, Rheumatology Grand Rounds "Osteoporosis: treatment with anabolic agents and case discussions"

Invited Speaker, AIMM/ASMBR John Haddad Young Investigator's Meeting, Snowmass, CO Invited Conference Faculty: Australian Rheumatism Society, Plenary Lecture on Osteoporosis; Meet

the Professor on Osteoporosis, Sydney, Australia Visiting Professor, University of Colorado, Denver, Grand Rounds in Rheumatology, and University of Colorado Bone Group

Visiting Professorship, University of Wisconsin Medical School Invited Faculty Member, NYU Update in Rheumatology, “Osteoporosis Update” 2004 Invited Course Faculty, Carl Pearson Rheumatology Symposium, Sponsored by UCLA, “Update on

osteoarthritis” and “Update on osteoporosis”, Huntington Beach, CA Invited Faculty and Distinguished Speaker: International SLE meeting, “Bone loss in SLE, what is the mechanisms and research update” Invited Distinguished Lecturer, EULAR, “Update on pathophysiology and new treatment for osteoporosis”, Berlin, Germany

Chair, Major Concurrent Session on Osteoporosis, EULAR, Berlin, Germany Course Faculty, Board Review of Rheumatology, Metabolic Bone Diseases

Invited Faculty, Speaker, Scientific Session Moderator on Inflammatory Bone Loss, Global Arthritis Research Network, GARN annual meeting, Montreal, Canada

Discussant, ASBMR, Special Session, “How to get an NIH grant” ASBMR annual meeting, Seattle, WA Invited Faculty and Distinguished Lecturer, Japanese Osteoporosis Society, “Glucocorticoid-induced

osteoporosis: the science and the therapy,” Tokyo, Japan Invited Special Guest Faculty, Nutrition and Chronic Disease, UC Davis 4th Annual Endocrinology Conference. “Glucocorticoid-induced osteoporosis,” Napa Valley, CA

2005 Visiting Professor, University of Rochester Medical Center Grand Rounds Invited speaker, ASBMR Annual Meeting, “Osteoporosis and Rheumatic Diseases”; “Tips on getting your first grant”

Invited speaker, ACR “How osteoporosis affects bone quality” Invited Speaker, Bone and Joint Decade Young Investigator Initiative, Ottawa Canada 2006 ORA, Osteoporosis Debate “We can screen and identify females to treat for osteoporosis” HSS Visiting Professor, Rheumatology Grand Rounds, Clinical Research Rounds NYU Review: “Osteoporosis: Is there a rational approach to fracture prevention?” Young Investigator Initiative: Work-Life Balance Visiting Professor, UCSD, Rheumatology Grand Rounds “Why bones break, osteoporosis” Harvard/Beth Israel Hospital, Visiting Professor, Lecture on Bone Quality Invited Grand Rounds Speaker, University of Mass., Update on Osteoporosis Invited Speaker, Grand Rounds UCLA Rheumatology, “Update on Osteoporosis” 2007 Invited Speaker, Grand Rounds, Univ. of Arizona, Rheum. “Update on Osteoporosis”

Invited Faculty, NYU course in Advances in Rheumatology, Ira Goldstein Memorial Lecture, “Osteoporosis-tailoring the treatment to the patient” University of Utah, Osteoporosis Case Conference

Invited Speaker, USC Medical School, Rheumatology Grand Rounds “Update on Osteoporosis” Invited Grand Rounds Speaker, Loma Linda School of Medicine, Rheumatology Grand Rounds, “Cases in Osteoporosis”. 2008 Rheumatology Grand rounds “Update on Osteoporosis” UCSD, La Jolla

Invited Speaker, Endocrinology Grand Rounds, “Glucocorticoid-Osteoporosis Update” South Carolina School of Medicine, Charleston, SC Invited Grand Rounds Speaker “Update on Rheumatoid Arthritis”, San Jose Regional Medical Center, San Jose, CA

Invited Speaker, UC Davis Update on Women’s Health, “Osteoporosis Update” Monterey California

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Faculty, Sun Valley Hard Tissue Symposium on Skeletal Tissue Biology. Speaker on “Tips on NIH funding for Junior Faculty, Sun Valley, Idaho Grand Rounds University of Colorado, Rheumatology Division. Update on Osteoporosis Treatment

Invited Speaker, Hip shape and hip OA, risk factors and associations. OARSI, Rome, Italy Invited Faculty, Western Region National Osteoporosis Foundation Meeting, “Update on Biomarkers” Anaheim, CA Invited faculty, Northern California Women in Endocrinology Meeting. “Glucocorticoid-induced osteoporosis”. Menlo Park, CA Invited speaker, Journal Watch Audio “More Results from a Study of Glucosamine and Chondroitin for Osteoarthritis of the knee”, www.j watch.org Invited Member of Task Force put together by Health and Human Services Secretary Michael Leavitt. Physical Activity Guidelines Advisory Committee Report 2008 for the Revised Physical Activity Guidelines announced by President George Bush Invited speaker, Journal Watch (published by Massachusetts Medical Society on “More results from a study on glucosamine and chondroitin” Invited Speaker and Moderator, Conference on AOSSM Post-injury OA meeting. “Update on biomarkers for OA” American Orthopedic Society for Sports Medicine, New Orleans, LA

2009 Invited Faculty, Advances in Musculoskeletal Magnetic Resonance Imaging/International Society for Magnetic Resonance Imaging, San Francisco, CA. “Update on the Cell Biology and molecular mechanisms in Osteoporosis”

Invited Visiting Professor, Department of Medicine, University of Missouri, Columbia, Missouri Invited Faculty, CME symposium at National Osteoporosis Foundation. Biomarkers for assessment of osteoporosis treatment, what the data suggests” Washington DC Invited Course Faculty, New York Academy of Sciences/ Mt. Sinai School of Medicine, NYC: Skeletal Biology and Medicine, “New Insights into Glucocorticoid Induced osteoporosis: From the Bedside to the Bench and back to the Bedside” Invited Faculty Speaker, Annual Meeting of the Osteoporosis Imperfecta Foundation and the Buchbinder family. Signaling in Bone and Targets for Therapy symposium, “PTH signaling in bone and PTH therapy”

Invited Course Faculty, 27th Carl M. Pearson Memorial Symposium “Frontiers of Rheumatology”, sponsored by UCLA CME. Marina Del Rey, CA. Lectures “Update on Osteoarthritis” and “Update on Osteoporosis” Invited Course Faculty, Fifth Annual Advances in the Diagnosis and Treatment of the Rheumatic Diseases CME program. Johns Hopkins Baltimore, MD, “Osteoarthritis update” Invited faculty, and Member of the Scientific Conference Committee, XI Congress of the International Society of Bone Morphometry, Zell am See, Austria “Glucocorticoid induced osteoporosis”, moderator of scientific sessions, abstract presentations Invited CME course faculty, UC Davis Health System Women’s Health Conference, “Update on arthritis in women” and “osteoporosis roundtable” Lake Tahoe, CA

Visiting Professor Tianan University, Tianan Taipei: - Grand Rounds Speaker “Glucocorticoid Induced Osteoporosis” - Faculty for Taiwan Society of Osteoporosis Annual Meeting, lectures “Update on

Bisphosphonates” and “Glucocorticoid Induced Osteoporosis” - Invited Speaker, Taiwanese Rheumatology Society on “Update on Osteoporosis Biology and

Treatment” Invited Speaker, SNOW Arthritis Foundation Biannual Osteoarthritis Meeting, “The association with hip shape and Osteoarthritis of the hip and knee”, Chicago, IL Invited Speaker, UCSF/UC Berkeley Embryology/Development Conference “FRZB polymorphisms, the bone and joint connection”

FDA public hearing committee member for OARSI workgroup on Guidelines, Washington DC 2010 Invited International Speaker, “Treat OA” annual Symposium on “The genetics of Osteoarthritis, FRZB,

the bone and joint connection” London, United Kingdom Invited Faculty, International Bone and Mineral Society IBMS, Davos Symposium, “The pathophysiology and Treatment of Glucocorticoid-induced Osteoporosis” Davos, Switzerland

Invited Speaker, EULAR, “The role of Bone in Osteoarthritis”, Rome, Italy Faculty Chair, Gordon Research Conference on Bioengineering. Proctor Academy, NH

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Invited Visiting Faculty, Rheumatology Grand Rounds “Update on Glucocorticoid induced osteoporosis from the bedside to the bench and back to the bedside” Salt Lake City, UT Visiting Professor, Division of Rheumatology Grand Rounds Speaker “Update on Osteoarthritis and Osteoporosis” University of Oregon, Portland, OR Course Faculty, “Immunologic Aspects of Bone Loss and New Emerging Treatments for Osteoporosis” 2nd Midwest Rheumatology Update, Chicago, IL Invited Grand Rounds Speaker, “FRZB: The bone and joint connection”, UCSF Department of Orthopedic Surgery International Invited Meeting Participant for TREAT OA: Osteoarthritis Phenotyping” Mallorca, Spain

2011 Organizing committee, abstract selection scientific committee and moderator of AOSSM/R13NIH, post-injury and OA, New Orleans, LA President’s Invited Speaker and ASBMR representative, Osteoporosis Committee of China Gerontological Society (OCCGS) Annual Meeting, Nanjing, China “Glucocorticoids: Rheumatoid arthritis and bone biology”

ACR Spring Symposium “Bisphosphonates: the good and the bad”, Chicago, IL Pfizer Visiting Professor, University of Manitoba, Winnipeg, Canada Rheumatology Grand Rounds and Rheumatology Society of Winnipeg “Osteoarthritis: the bone and joint connection” and mentored fellows Visiting Professor, UCSD Rheumatology, Grand Rounds speaker: “Update on osteoporosis and osteocytes” 8th Annual Osteoporosis: New Insights in Research, Diagnosis, and Clinical Care, UCSF. Lecture 15 “Estrogen, SERMS”

2012 Invited Faculty, Excellence in Rheumatology, Madrid Spain Rib Awardee lecture “Wnt signaling pathway, the bone and joint connection”, IBMS, Sun Valley, ID Invited Faculty, ANZ Osteoporosis Society, First Asian Osteoporosis Meeting, ORS Australia and Western Australia Rheumatism Society, “GC induced bone loss” and “Wnt Signaling the bone and joint connection” and “Inflammatory Bone Loss” Perth, Australia

2013 Invited Speaker and Moderator, AAOS Bone Quality Symposium, Chicago, IL, speaker “Glucocorticoid Induced Osteoporosis a lesson in Bone Quality” Invited speaker, Puerto Rico Rheumatism Society, San Juan, Puerto Rico “Update on OA”, “Update on osteoporosis”, “Glucocorticoid induced osteoporosis” Invited faculty Idaho Rheumatism Association, Twin Falls, ID “Update on Gout”, “Update on SLE”

2014 Invited Speaker, Grainau, Germany, 14th Bergmeyer Conference on Women’s Health, International Federation of Clinical Chemistry and Laboratory Medicine “Osteoporosis, an Update on Biomarkers”

Keynote Speaker, Case Western Reserve University, Cleveland, Ohio, lecture on "The treatment of osteoporosis and rheumatoid arthritis with a little help from your own stem cells"

Invited Speaker, Rheumatology Grand Rounds, University of California, San Diego, “The epidemiology and treatment of osteoporosis in men, with a little help from your own stem cells”

Invited Speaker, 11th Annual Osteoporosis Meeting: New Insights in Research, Diagnosis, and Clinical Care, University of California, San Francisco, “Osteoporosis in chronic kidney disease”

Invited Speaker, 1st Annual Educational Lecture, Northern California Rheumatology Society, Sacramento, CA, “ Keynote Invited Speaker, Argentine Congress of Osteoporosis, Buenos Aires, Argentina, September, “Reversal of bone loss driving stem cell to bone”, “Glucocorticoids, and osteocytic Autophagy”, “Risk of hip fracture and aortic calcifications” Invited Faculty, 2014 California Providers’ Best Practices & GPRA Measures Continuing Medical Education Conference and Diabetes Day, Sacramento, CA, “Osteoporosis” Invited Speaker, 7

th International Workshop on Osteoarthritis Imaging, Reykjavik, Iceland,

“Background on a NGF therapy and results from the placebo-controlled clinical trials including the non-serious joint related adverse events” Invited Speaker, Northern California Rheumatology Society, Sacramento, CA, “Post-EULAR Clinical Update”

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Invited Speaker, XXXI Congresso Brasileiro De Reumatologia SBR, Belo Horizonte, Brazil, “Osteoporosis: how to choose a specific treatment”, “Osteoporosis treatment: making decisions based on risk factors” Invited Keynote Speaker, Lupus Foundation of Northern California, “Osteoporosis in patients with SLE and rheumatic disease ”, UCDMC, Sacramento, California ASCI/AAP Joint meeting CME Invited Speaker, 7th International Workshop on Osteoarthritis Imaging, Reykjavik, Iceland Selected by Dean Academic Dean of Harvard Medical School to serve on an external ad hoc promotions for a promotion to professor of medicine at Harvard Medical School Invited Speaker, XXXI Congresso Brasileiro De Reumatologia SBR, Belo Horizonte, Brazil AAOS Invited Panel member Non-Arthroplasty Treatment of Osteoarthritis of the Knee

2015 “RA Treatment and Pain of Inflammation”, Department of Pain Medicine, UC Davis “Translational Research in Musculoskeletal Diseases: From the Bench to the Bedside with Mesenchymal Stem Cells for Bone Diseases”, Department of Orthopaedic Surgery, School of Medicine, The Johns Hopkins University “Treatment of Musculoskeletal Diseases with Your Own Stem Cells – Musculoskeletal Research”, Mayo Clinical Guest Lecturer, Musculoskeletal Medicine Day, University of Pennsylvania “Translational Research in Musculoskeletal Diseases from the Bedside to the Bench and Back to the Bedside with Stem Cells and Glucocorticoids”, Orthopedic Grand Rounds, UC Davis “UCSF/UCB/UCD – Planning Grant”, “P50 Centers of Research Translation (CORT)”, “Specialized Center of Research (SCOR)”, School of Medicine Dean’s Symposium, UC Davis “Biosimilars in RA”, CME, Oregon Rheumatology Alliance, Portland Oregon Visiting Professor, “Treatment of bone diseases, with hybrid compound, LLP2A-Ale and a little help from your own stem cells”, Pfizer, University of Alabama at Birmingham Research Universities in the 21st Century”, National Academies of Sciences, Engineering, and Medicine, August 2015 Invited Speaker, “A review of anti-NGF treatments for painful arthritis conditions”, An International Workshop for Pain and Osteoarthritis, September 2015 Key Note Speaker, Musculoskeletal Research Day, University of Pennsylvania and Children’s Hospital of Pennsylvania “Treating bone diseases with your own stem cells”, November 2015 Invited Distinguished Speaker, “Use of mesenchymal stem cells to the bone for the treatment of osteoporosis and fractures”, The Third International Biomedical Forum of West China (IBFWC), Shihezi, China Invited Distinguished Speaker, “Use of mesenchymal stem cells to the bone for the treatment of osteoporosis and fractures”, The Third International Biomedical Forum of West China (IBFWC), Urumqi, China Invited Distinguished Speaker, 2015 Suzanne Bernier Lecture, University of Western Ontario Invited Speaker, Oregon Rheumatology Alliance (accredited by Purdue University) Invited Speaker, “An update on anti-nerve growth factor Treatments for Osteoarthritic pain”, An International Workshop for Basic and Clinical Researchers, Johannesbergs Slott, Stockholm, Sweden Invited Moderator, “Session 5: Recent insights from Joint Imaging in Population & Clinical Studies”, ISMRM Workshop on Imaging Based Measures of Osteoarthritis, Pacific Grove, CA, September 2015

2016 Invited Abstract Review, Annual European Congress of Rheumatology EULAR 2016, London, United Kingdom, June 2016

“Current and Emerging Strategies for Osteoporosis Diagnosis and Treatment”, Internal Medicine Grand Rounds, UC Davis, April 2016

Featured Speaker, Arthritis Foundation (AF) Accelerating Osteoarthritis Clinical Trials Conference, Atlanta Georgia, February 2016

Invited Faculty for "Year in Review, Clinical Osteoarthritis" Osteoarthritis and Cartilage Research Society, April 2016, Amsterdam, Netherlands

Invited Speaker: 2016 Program Committee of the American Society for Bone and Mineral Research, Atlanta, GA. “Advances in Osteoarthritis Imaging and Treatment”, September 2016

Invited Mentor, “Networking Breakfast”, Membership Engagement and Education Committee, American Society for Bone and Mineral Research

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Invited Speaker: UCSD Department of Medicine, Grand Rounds Visiting Professor "Osteoporosis" October 5, 2016

Lecture Session Chairperson, 4th World Congress on Controversies, Debates & Consensus in Bone, Muscle & Joint Diseases, Barcelona, Spain. “Challenges in the management of osteoarthritis”. October, 2016

Session Presenter, 4th World Congress on Controversies, Debates & Consensus in Bone, Muscle & Joint Diseases, Barcelona, Spain. “Debate: The Usefulness of Spinal Steroid Injections for Sciatica and Low Back Pain”. October, 2016

Session Presenter, 4th World Congress on Controversies, Debates & Consensus in Bone, Muscle & Joint Diseases, Barcelona, Spain. “Debate: Pain in Osteoarthritis: Is Pain Relief Good or Bad for Patients?”. October, 2016

American College of Rheumatology- Invited member of Task Force for Guidelines for Treatment of glucocorticoid induced bone loss

Elected member of Task Force for "Cell based Therapies" American Society of Bone and Mineral Research

Visiting Professor, "Treatment of Bone Diseases with a Little Help from your own Stem Cells", University of Rochester Medical Center

Invited Speaker: 2016 ACR/ARHP Annual Meeting in Washington, DC. “Challenging Cases in Osteoporosis Management.

October Tinsley Randolph Harrison Society Visiting Professor at Vanderbilt University School of Medicine, Department of Medicine

Review Panel Member, NIAMS Ancillary Studies Teleconference, November 2016 Contributor, 4th World Congress on Controversies, Debates & Consensus in Bone, Muscle & Joint

Diseases Invited Speaker: 2016 Program Committee of the American Society for Bone and Mineral Research,

Atlanta, GA. “Advances in Osteoarthritis Imaging and Treatment”, September 2016 Harrison Society Visiting Professor, Vanderbilt University, Nashville, TN. Medicine Grand Rounds:

“Glucocorticoid Induced Osteoporosis: A Translational Journey from the Bedside to the Bench and Back to the Bedside”, October

2017 Featured Speaker, Arthritis Foundation (AF) Accelerating Osteoarthritis Clinical Trials Conference, Atlanta Georgia

Invited Speaker, University of Kentucky Medical School Invited Speaker, University of Kentucky Medical School, Performed CME talk in Denver, CO January 19

“Evaluation of a New Rheumatoid Arthritis Patient, Treatment and Trade-Offs” Invited Speaker, Rush University Medical Center, Rheumatology Grand Rounds, Chicago IL, “Glucocorticoid Induced Osteoporosis, an Update”, March Visiting Professor and Medical Grand Rounds Speaker “ Outcomes in Rheumatoid Arthritis have changed and we can measure them” November, LSU, New Orleans, LA

2018 Invited Speaker: Medicine Grand Rounds, NYU School of Medicine, “Glucocorticoid Induced Osteoporosis: A Translational Journey”, February 26,2018 Invited Rheumatology Grand Rounds Speaker “ Update on Psoriatic Arthritis” Emory University Medical Center, Atlanta, Georgia, April OARSI symposium speaker, Preclinical models of OA and Wnt inhibition, Liverpol, England April. 2018 Invited Speaker., California Rheumatism Alliance “ Update on Osteoporosis”

San Francisco, California. May 2018 Rio De Janiero, Rheumatology Society, “ Update on treatment of knee OA with Undenatured Collagen” Brazil, May 2018 Sal Paulo Rheumatology Society, “ Update on the treatment of OA with Undenatured Collagen” Sal Paulo, Brazil, May 2018 Visiting Professor and special medical school lecture. “ Systemic Lupus Erythematous” Guangzi Medical University, Naning, China. June 2018 Awarded. Visiting Professor of Guangzi Medical University in Guangxi China for 3 years, 2018 Awarded, Visiting Professor, Kuming Argicultural University, Kuming China for 3 years. Invited Faculty, UCSF, Update on Osteoporosis, CME course. “ Treatment of osteoporosis with denosumab”. July 12-13, 2018. San Francisco, California

25

Invited Faculty, Floride Rheumatology Society. Talks “ Update on Osteoporosis” and “ Glucocorticoid-induced osteoporosis”. Orlando, Florida, July 2018 Visiting Professor, Medical Grand Rounds “ Update on the treatment of Rheumatoid Arthritis”. SUNY Upstate University, Syracuse New York, July 2018 Visiting Professor, Medical Grand Rounds, “ Update on the treatment of Rheumatoid Arthritis”. Loma Linda University Health Center, Loma Linda, California, July 2018 Florida Society of Rheumatology, Invited Faculty, “ Update on treatment of osteoporosis”.Orlando, Florida, July 2018 UCSF, Update in Osteoporosis. Invited Faculty. “ Denosumab Therapy”, SF, CA July 2018 Primary Sclerosing Cholangitis Socity, Invited Faculty “ Osteoporosis and PSC”, Sacramento, California June 2018 APLAR, invited speaker and award wining abstract. “ SMO409^” a Wnt antagonist for the treatment of knee OA”. Kaohsiung, Taiwan. September 6-9, 2018. Invited Faculty, Napa Pain Conference. “ update on osteoarthritis treatment”. Napa, California August 17-19, 2018

SYMPOSIUM (selected meetings) 1989 Organizer of “The Effects of NSAIDs on Cartilage and Bone Metabolism” sponsored by an educational

grant from Syntex Laboratories 1992 Co-director of conference entitled “Office Arthroscopy for the Rheumatologist,” Santa Barbara, CA,

sponsored by UCLA Extension and ACR 1993 Organizer “Arthroscopy Study Group” at the Regional ACR meeting Denver, CO Organizer and speaker at NIH/NIAMS/NLS Workshop on methodologies to interpret digitized

radiographs from the NHANES II Survey Organizer and speaker at “Menopause, a practical guide” for the SFGH employees, Speaker for Osteoporosis

1997 Program Chairperson, Western Regional American College of Rheumatology, San Diego, CA 1998 Program Co-chair, ACR spring meetings 2001 Program Chair, Osteoporosis Clinical Review, sponsored by ACR and ASBMR, in San Francisco, CA 2008 Co- organizer and UCDMC sponsored “Women in Rheumatology” conference, held in Sonoma with

funds of $30,000 raised

UNIVERSITY COURSE INSTRUCTION

1990-2004 Rheumatology sub-specialty elective for 4th year medical students Rheumatology lectures for Medicine 110, the third year medical students’ core medicine rotation 1993 Pathophysiology of Disease for fourth year medical students “Osteoporosis” 1992-2004 Clinical Pharmacology for the rheumatic diseases, fourth year medical students, Medicine 140.22F 1994-2004 Introduction to Clinical Medicine, small group leader for RA cases 1994 Scientific Foundation of Clinical Prevention for Women “Prevention of Osteoporosis” 1993-95, 97, 98 Family and Community Medicine Core Rheumatology Lectures, “Rheumatoid Arthritis and Vasculitis” 1995-1997 Intro to arthritis, Nurse Practitioner Core Curriculum and preceptor, School of Nursing 1998-2002 Oral Biology Seminar Series, graduate and dental students seminar 1992-present Rheumatology, Core UCSF Medicine Residents Curriculum in Rheumatology 2001-2005 Department of Medicine and Epidemiology Faculty for Training in Clinical Research Course, (TICR)

Instructor for Clinical Research Methods Workshop 2004 Department of Medicine and Epidemiology, Training in Clinical Research for Medical Students, Course

Instructor Head

26

2005 Controversies in Clinical Research, UCDMC K30 2006 Building a career in Academic Medicine, UCDMC K30

Department of Epidemiology and Biostatistics UCSF, Training in Clinical Research for Medical Students. 150.01 co IOR

UCDMC K30, course on “Controversies in Clinical Research” co–IOR UCDMC Endocrinology Medical Student course “Osteoporosis” IMD405, OBG430, SUR430, 2005 UCDMC Gender Based Medicine, 3 and 4th year medical Students, “Osteoporosis in men and women

OBG493/CAR493 (2005-2009) 2008 Internal Medical Grand Rounds, “Update on Glucocorticoid-induced Osteoporosis” Internal Medicine Residents Clinical Conference “Rheumatologic Emergencies: Giant Cell Arteritis” Endocrinology Grand Rounds/Clinical conference “Osteoporosis Cases” UC Davis Course OSU 421 Musculoskeletal System “Osteoporosis and Metabolic Bone Diseases” 2009 MCRTP/K30, IMD 290C Critical assessment of clinical studies: Translational Journal Club, co-IOR MERN IMD 405 lecturer “Disorders of Bone Metabolism” and “Treatment of Bone Disorders”

Internal Medicine Core Rheumatology Lectures “Rheumatologic Emergencies” Rheumatology Subspecialty Resident, Board Review, Tuesdays every other week, (1 or 2 hours per

month) SSM in basic science principles relating to gender medicine OBG493/AR493. Lecture “Bone metabolism and osteoporosis”

2010 Rheumatology Subspecialty Core Content Review (1 hour twice a month) Internal Medicine Core Rheumatology Lectures: SLE and Osteoporosis Co-IOR Translational, T1 Journal Club, twice a month K12/MCRTP/ T32 Internal Medicine Clinical Case Rounds “Vasculitis” 2011 Rheumatology Subspecialty Core Curriculum Conference (1 hour twice a month) Internal Medicine Clinical Grand Rounds, “Osteonecrosis and HIV” Co-IOR Translational, T1 Journal Club, twice a month K12/MCRTP/ T32 2012 Co-IOR Translational, T1 Journal Club, twice a month K12/MCRTP/ T32 Clinical Epidemiology and Study Design Course, Instructor Small Group Internal Medicine Grand Rounds Family Practice Grand Rounds Co-IOR BIRCWH Journal Club, K12-WIP Instructor, Rheumatoid Arthritis didactic lectures to Residents and Interns Instructor, Spring Course NRS 298, Nursing Student Class Lecture 2013 Judge, ASCI/AAP Joint Meeting Abstract Awards for Young Investigators Internal Medicine Grand Rounds, “An Update on Gout: New Biology and Treatments”

Facilitator, Epidemiology Literature Review Instructor, Doctoring 1 Small-Group Discussion

2014 Instructor/Proctor, Internal Medicine Clerkship Oral/Clinical Exam Instructor, Doctoring 1 Small-Group Discussion Guest Instructor, Approach to Arthritis and Collagen Vascular Diseases, School of Nursing

Judge, ASCI/AAP Joint Meeting Abstract Awards for Young Investigators Co-IOR Translational, T1 Journal Club, twice a month K12/MCRTP/ T32

2015 Co-IOR Translational, T1 Journal Club, twice a month K12/MCRTP/ T32 Instructor, Introduction to Clinical Research, Epidemiology Master’s in clinical research, co-IOR Instructor, Critical Assessment of Biomedical Literature Instructor, Endocrinology, Nutrition, Reproduction, Genetics (ENRG) Clinical Epidemiology and Study Design Course, Instructor Small Group Syllabus: Psoriatic Arthritis “Osteoarthritis and Ankylosing Spondylitis”, OSU-42 2017 Co-Instructor, “Critical Assessment of the Biomedical Literature”, CLH 211,

27

POSTGRADUATE TRAINEES

Name and Degree Role Project Years/Term Present Position

Deidre Gramas, MD, MPH

Rheumatology mentor and research mentor

Predictors of knee arthroscopy findings in OA.

1991-1994 (2003): Private Practice in Rheumatology, Portland ME

Patrick Mrockowski, MD

Rheumatology mentor and research mentor

Estrogen analogs for the treatment of osteoporosis

1992-1995

(2003): Chief, Division of Rheumatology, Associate Professor of Medicine Albany Medical Center, Albany, NY (2005):deceased

Andrus Kaneps, DVM, PhD

Post doctorate Research Fellow

The effects of naproxen on immobilization induced bone loss and recovery in dogs

1994-1996

(2003): Professor of Medicine School of Veterinary Medicine Oregon State University, Corvalis, OR

Victor Sloan, MD

Rheumatology clinical research mentor

Review of biologic therapies for Rheumatic diseases

1994-1995

(2003): Professor of Medicine, Division of Rheumatology Robert Wood Johnson School of Medicine, Princeton, NJ (2007-present): Medical Director, Novartis Pharmaceuticals, NJ

Jennifer Thompson

Undergraduate and graduate research fellow

Epidemiology of glucocorticoid induced osteoporosis

1994-1996

(2004-present): Pediatrician, Santa Clara Valley Medical Center

Eva Aagaard, MD

Rheumatology mentor and research mentor

Predictors of the patients and physicians who obtain treatment to prevent glucocorticoid induced bone loss

1996-1997

(2003-2015): Assistant Professor of Medicine, UCSF (2015-present) Professor of Medicine, UCSF

Paula Lin

Rheumatology Research and Education Foundation Scholar

Clinical and laboratory preceptor for rheumatology

Summer 1997 (2003): Resident in Dermatology, University of Iowa (2003-present): private practice

Boris Ratner, MD

Rheumatology clinical and research mentor

Association of arthritis with hepatitis C infection

1996-1998 (2003-present): Private Practice, Los Angeles, CA

Nisha Manek, MD

Rheumatology Research Mentor

Patient characteristics associated with taking nutriceuticals for joint pain.

1998-1999 (2003-present): Assistant Professor of Medicine and Rheumatology Faculty of Rheumatology, Mayo Medical Foundation, Rochester, MN

Raphael Fentes, MD

Research mentor in Bone Metabolism

Epidemiology of osteoporosis in renal disease patients.

1999 (2003-present): Private Practice in Nephrology, San Diego, CA

Qaiser Rehman, MD

Research mentor 1999-2001 (2003-present): Private Practice Rheumatology, Houston, Texas

28

POSTGRADUATE TRAINEES

Name and Degree Role Project Years/Term Present Position

Serge Lindner, MD

Research Mentor

General medicine residency research project on osteoporosis guidelines

(2005-present): geriatrician

Kathy Lee, DDS, MS

Research Mentor Dental project on using fractal analysis to determine bone loss in Periodontal Patients

1999-2001 (2003-present): Orthodontist, Palo Alto, CA

Muna Khan, MD

Clinical Researcher in Inflammatory Bone Disease

1999-2002 (2006): Pediatric Neurologist

Susan Ksieh, DDS, MS

Co-Mentor Master's thesis advisor for Orthodontics master's thesis; Research Mentor

Study of the Utilization of fractal analysis to assess the efficacy of bisphosphonates in the adjunctive treatment of chronic periodontitis.

2002-2004 (2006-present): Clinical Professor of Dentistry, Orthodontics, UCSF Private Practice, Dublin, CA

Eric Buxton, MD

Endocrine Fellowship Research Mentor

Project: Treatment of glucocorticoid-induced bone loss with PTH and risedronate

2003-2004 (2005-present): Endocrinologist, SF, CA

Mary S Beattie, MD

Clinical Research Mentor for Fellowship in Women's Health

Research Project: Evaluating the association of statin use on the development and progression of osteoarthritis of the hip in elderly Caucasian women.

(2004-present): Associate Professor in Residence, Department of Medicine, UCSF (20130-present): Genentech, South SF, CA

Mary Beth Humphrey, MD

Co- Mentor in Bone Biology as Rheumatology Research Fellow

Research Project: The effect of DAP-12 Receptors on the development and activity of osteoclasts. This project included basic molecular biology, bone biology, trabecular bone structure and biochemistry. I mentored her on bone biology, bone structure aspects of the project.

2002-2005 (2004): Assistant Adjunct Professor of Medicine at UCSF (2015) Professor of Medicine, Chief Division of Rheumatology, Oklahoma Health Science Center, Oklahoma, OK

Iljie Kim, BS, MS

Clinical Research Mentor for 3rd year UCSF/UCB Medical Student Project. American College of Rheumatology Clinical Research Fellowship

Research Project: Introduction to Clinical Research of Osteoarthritis and glucocorticoid-induced osteoporosis. Introduction to medical writing with review article to be

2003-2003

(2005): Graduated UCSF

29

POSTGRADUATE TRAINEES

Name and Degree Role Project Years/Term Present Position

published in peer-review journal

Kuochiang Lian, BS, MS

Doris Duke Clinical Research Fellow Mentor

Research Project: How does trabecular and cortical bone structure of glucocorticoid and postmenopausal women differ by QCT measurement; Genetics of osteoarthritis; MRI to assess 3D bone structure in glucocorticoid-treated subjects?

2002-2005 (2003): 4th year medical student at UCSF and Doris Duke Clinical Research Fellow (2006-present): Clinical Professor of Psychiatry, UCSF, CA

Ariella Kelman, MD

Clinical Research Rheumatology Fellow

2003-2004

Adjunct Professor of Medicine/Rheumatology, Stanford University Medical Center Medical Director, Genentech, South SF, CA

Kendal Hamann, MD

Clinical Research Endocrinology Fellow

Research Project: The association of testosterone and serum inflammatory markers to bone mineral density in HIV positive men

2006-2007 Endocrinologist, Kaiser, Santa Rosa, CA

Dina Jones, PT, PhD Assistant Professor Evaluation of distance evaluation for THR in rural Virginia

2006-2009 Professor of Physical Therapy, West Virginia University

Jennifer Tseng, MS

Medical Student UCDMC

Evaluation of mineralizing gene and Wnt pathway gene expression in a mouse model of glucocorticoid induced bone loss

2006-2007 Clinical Orthopaedist

Mondipna Ratnarathorn, MS

Medical Student UCDMC, working on Master’s degree

Evaluation of alpha v beta 5 integrin and osteoblast and osteoclast maturation

2006-2010 Clinical Dermatologist, Reno, NV

Guive Balooch, PhD Post-doctoral student Spitting time with UCDMC and Lawrence Berkeley Lab

Localized reductions in elastic modulus and mineralization within trabeculae and how this contributes to overall bone quality

2005-2006 Vice President of Research and Innovation, L’Oréal NYC, NY

Krishna Chaganti, MD

Physician Scientist investigator award, junior investigator with visiting scholar at UCSF

Epidemiology of hip OA in elderly men

2006-2007 Associate Clinical Professor of Medicine and Rheumatology, UCSF

Kassim Javaid, MD Co-mentor with Michael Nevitt

Epidemiology of hip and knee OA

2006-2007 Professor of Rheumatology Chair of

30

POSTGRADUATE TRAINEES

Name and Degree Role Project Years/Term Present Position

Visiting Scientist Epidemiology, Oxford College of Medicine, Oxford England

Balvinder Rehal, MD UCDMC Medical Student years 1-2

Assessment of pH change by nanoprobes of osteocytes exposed to glucocorticoids

2007-2008 Clinical Dermatologist, Sacramento, CA

Nadeen Chadine, PhD

Post-doctoral fellow at LLNL and collaboration with UCDMC

To determine how integrins interact with chondrocytes after loading

2007-2008 Director, Bioengineering-Biomechanics Laboratory Associate Investigator, Center for Autoimmune and Musculoskeletal Diseases, The Feinstein Institute for Medical Research

Elizabeth Regan, MD

Instructor of Medicine at Univ. of Colorado Paul a Beeson Mentor

Evaluation of oxidative gene SNPs and OA

2007-present Associate Professor, University of Colorado

Zhigiang Cheng, MD MD, PhD Post-doctoral Scholar In Aging lab/Dept of medicine

To characterize sfrp1 tg mouse and its response to PTH in male and female mice

2006-present Project Scientist, Department of Medicine, UCSF

Carolyn Meloty PhD candidate Cell Biology

Tenacins and bone cell development

2006-2008 Molecular Biologist

Mohammad Shahnazari, PhD

PhD Post-doctoral scholar

To assess changes in bone quality in an animal model treated with bone active agents

2008-2011 Health Sciences Liaison, Merck

Barton Wise, MD Assistant Professor of Medicine

Risk factors for total knee replacement in women and men, is it pain perception

2008-present Associate Professor with tenure, UC Davis

Vivian Dai, PhD PhD, Visiting Post-doctoral Scientist

Wnt agonist treatment to reverse osteoporosis

2008-2010 2012-2013

Scientist, Shanghai, China

Steven Ing, MD Assistant Professor of Medicine OHU

Glucocorticoid withdrawal in renal transplant patients. USBJD Young Investigator Mentee

2008-2011 Assistant Professor, Division of Endocrinology, Diabetes and Metabolism, School of Medicine, OHU

Kali Luker, MD Medical Student USC To determine the association of hip geometry with hip fracture and risk of OA in individuals with FRZB polymorphisms

2007-2010 Assistant Clinical Professor Pediatric Orthopaedics, Stanford

Tania Ferguson, MD

Mentored Clinical Research Program – UCDMC

Improving the identification and management of osteoporosis for inpatients admitted with fragility fractures

2009-2011 Professor of Orthopedic Surgery, School of Medicine, University of Washington

Norra Kwong, MD Internal Medicine UCDMC research

The association of FGF23 and GC induced

2009-2012 Endocrinologist, Private Practice, Roseville, CA

31

POSTGRADUATE TRAINEES

Name and Degree Role Project Years/Term Present Position

rotation changes in bone and kidney metabolism

Christoph Sterling, MD

UCSF Visiting Scholar Co-mentor with Dr Thomas Link in Radiology

The association of MRI findings T2 and T1 and OA cartilage changes associated with exercise

2008-2009 Professor of Radiology, Germany

Andrew Wise, MS UCSF Department of Biological Chemistry Graduate study

The activation of GRE genes with DEX treatment in the osteocyte and cross talk with osteoblasts and osteoclasts

2009-2010 Scientist, Private Industry

Mina Guan, PhD Post-doctoral Scholar UCDMD

The effect of an alpha5Beta1 integrin as an anabolic treatment for osteoporosis and skeletal defects

2009-2011 Assistant Professor of Biology

Julie Baker-Lepain, MD, PhD

Rheumatology Senior Subspecialty Fellow at UCSF, in MCRTP

The association of hip shape with fracture and hip shape and polymorphisms of FRZB and hip OA

2009-2012 Staff Rheumatologist, Kaiser Permanente, Walnut Creek, CA

Wendy Katzman, PT, PhD

Assistant Professor of Physical Therapy and Epidemiology

The association of kyphosis with balance and upper body muscle strength in elderly women

2009-2010 Associate Professor, Department of Physical Therapy and Rehabilitation Science, UCSF

Sarah Amugongo, PhD

Post-doctoral Research Scholar

The effect of bone active agents on bone quality in a preclinical model of osteoporosis after sequential therapy

2010-2013 Assistant Professor, St. Olaf College, Northfield, MN

Daniel Evans, PhD Post-doctoral Research Scholar

The genetic associations of hip OA using GWAS data

2011-2015 Associate Scientist, California Pacific Research Institute, SF, CA Adjunct Assistant Professor, Epidemiology, UCSF, SF, CA

Abhijit Chaudhari, PhD

Assistant Professor BIRCWH Scholar

The association of CMC joint shape and kinematics with hand OA in women and men

2012-present Associate Professor of Radiology, UCDHS

Blaine Christiansen, PhD

Assistant Professor Mentor for K99, R01

The association of traumatic knee injury in mice with OA development

2012-present Assistant Professor of Orthopaedic Surgery, UCDHS

John MacKenzie, MD

Assistant Professor in Residence & Chief, Pediatric Radiology, UCSF

NIH K08 training grant, “Molecular imaging detection & treatment monitoring of arthritis 2012-2017

2013-2015 Associate Professor in Residence & Chief, Pediatric Radiology, UCSF

32

POSTGRADUATE TRAINEES

Name and Degree Role Project Years/Term Present Position

Mona Walimbe, MD UCSF Endocrinology (Clinical & Research) Fellow, Residency Program, Department of Medicine

Osteoarthritis and Diabetes in the MOST Cohort

2013-2016 Private Endocrinology Practice in New Jersey

Geetha Mohan, PhD Post-Doctoral Research Scholar

Osteoarthritis Animal Models

2013-2017 Postdoctoral Scholar, School of Medicine, UCSF

Sergey Magnitsky, PhD

Project Scientists at UCSF

Imaging MSCs on the bone surface

2013-2017 Assistant Research Scientist, Department of Radiology, UCSF

Lorna Ringwood, PhD

Post-Doctoral Research Scholar

Treatment of osteonecrosis with LLP2A-Ale in mice

2013-2016 (2016): Medical Student, Wake Forest University, Medical School

Haley Berka, BS Junior Specialist - Researcher

Studies Biomarkers for osteoarthritis and osteoporosis Effect of bone active agents on bone strengthen

2012-2015 (2015): Medical Student, Emory University Medical School

Amanda Nelson, MD

Assistant Professor of Medicine and Rheumatology

Mentor for active shape modeling for OA, K award

2012-2017 Associate Professor, University of North Carolina, Chapel Hill, NC

Melissa Kacena, PhD

Mentor for Assistant Professor

Mentored her on grant writing in bone biology

2010-2013 Associate Professor with tenure Indiana University School of Medicine

Aris Alexandrou, PhD

Post-Doctoral Research Scholar

Circadian rhythms and MSCs

2015-2016 Postdoctoral Scholar, UC Davis

Tara Rogers, PhD Graduate Student and Post-doctoral Research Scholar

Synchronize osteoporosis treatments with circadian rhythm.

2015-2018 Graduate Student, PhD

Alanna Dubrovsky, BS, MD Candidate class of 2020

Medical Student Effects of decreased blood supply on development of osteonecrosis

2017-2020 Medical Student, UC Davis, Lab Assistant

INDS HELD AT FDA

46,523 for hPTH (1-34) treatment of glucocorticoid induced osteoporosis

62,753 for Risedronate for the treatment of moderate to severe periodontal disease.

PEER REVIEWED PUBLICATIONS Duplicates

1. Lane NE, Bloch DA, Jones HH, Marshall WH Jr, Wood PD, Fries JF. Long-distance running, bone density, and osteoarthritis.

JAMA. 1986 Mar 7;255(9):1147-51. 2. Lane NE, Bloch DA, Wood PD, Fries JF. Aging, long-distance running, and the development of musculoskeletal disability. A

controlled study. Am J Med. 1987 Apr;82(4):772-80.

3. Fries JF, Bloch DA, Segal MR, Spitz PW, Williams C, Lane NE. Postmarketing surveillance in rheumatology: analysis of purpura and upper abdominal pain. J Rheumatol. 1988 Feb;15(2):348-55.

33

4. Lane NE: Does running cause permanent joint damage? J Musculoskeletal Dis 4:17-24, 1987. 5. Gaston J, Strober S, Gandor D, Solovera J, Lane NE, Schurman D, Hoppe RT, Vaughan J, Allison AC: Dissection of the

mechanisms of immune injury in rheumatoid arthritis using total lymphoid irradiation. Arthritis Rheum 31:21-30, 1988.

6. Lane NE, Fries JF: The relationship of running to osteoarthritis and bone density. Comprehensive Therapy 1988.

7. Lane NE, Bloch D, Jones H, Simpson U, Fries J: Osteoarthritis in the hand. A Comparison of handedness and hand use. J Rheumatol 16:637-642, 1989.

8. Parth P, Dunlap WP, Kennedy RS, Ordy JM, Lane NE. Motor and cognitive testing of bone marrow transplant patients after

chemoradiotherapy. Percept Mot Skills. 1989 Jun;68(3 Pt 2):1227-41.

9. Lane NE, Bloch D, Jones H, Simpson U, Fries J: Running, osteoarthritis, and bone density: Initial longitudinal study. Am J Med 88:452-459, 1990.

10. Michel BA, Lane NE, Jones HH, Fries JF: Plain X-rays can be useful in estimating lumbar bone density. J Rheumatol 17:528-

531, 1990.

11. Lane NE, Coble T, Kimmel D: The effect of Naprosyn on cancellous bone in ovariectomized rats. J Bone Min Res 10:1029-1035, 1990.

12. Lane NE, Schubert M: Allergens as etiologic in rheumatic disease. JAMA 263:117, 1990.

13. Spector M, Shortkoff S, Hsu H-P, Lane NE, Sledge C, Thornhill T: Tissue changes around loose prostheses: A canine model

to investigate the effects of an anti-inflammatory agent. Clin Orthopedics 261:140-152, 1990.

14. Lane NE, Baptista J, Orwoll E: Bone mineral density of the lumbar spine in women with endometriosis: a population based study. Fertility and Sterility 55:537-542, 1991.

15. Lane NE, Baptista J, Snow-Harter C: Bone mineral density of the lumbar spine in endometriosis subjects compared to an

age-similar control population. J Clin Endo Metab 72:510-515, 1991.

16. Michel BA, Lane NE, Bloch DA, Fries JF: Effect of weight-bearing exercise on lumbar bone mass after fifty. Ann. Med. 23:397-401, 1991.

17. Lane NE, Williams RJ III, Smith RL, Schurman DJ: Inhibition of interleukin-1 induced chondrocyte protease activity by a

corticosteroid and a nonsteroidal anti-inflammatory drug. J Rheumatol 19:135-139, 1992.

18. Kimmel D, Coble T, Lane NE: Long term effect of naproxen on cancellous bone in ovariectomized rats. Bone, 13(2):167-72, 1992.

19. Spector M, Shortkoff S, Hsu HP, Lane NE, Sledge CB, Thornhill TS. Synovium-like tissue from loose joint replacement

prostheses: Comparison of human material with a canine model. Seminars in Arthritis and Rheumatism 21(5):335-344, 1992.

20. Michel BA, Fries JF, Bloch DA, Lane NE, Jones HH. Osteophytosis of the knee: association with changes in weight-bearing

exercise. Clin Rheumatol. 1992 Jun;11(2):235-8.

21. Michel BA, Lane NE, Bjorkengren A, Bloch DA, Fries JF: Impact of running on lumbar bone mineral density: a five-year longitudinal study. J Rheumatol 19:1759-1763, 1992.

22. Ratcliffe A, Rosenwasser MP, Mahmud F, Plazer PA, Fatemeh SN, Lane NE, Mow VC: The in vivo effects of naproxen on

canine experimental osteoarthritic cartilage: composition, metalloproteinase activities and metabolism. Agents and Actions, 39:207-211, 1993.

23. Michel BA, Bjorkengren AG, Lambert E, Lane NE, Fries JF, Bloch DA. Estimating lumbar bone mineral density from routine

radiographs of the lumbar spine. Clin Rheumatol. 1993 Mar;12(1):49-52.

34

24. Lane NE, Michel B, Bjorkengren A, Oehlert J, Shi H, Bloch DA, Fries JF: Running and osteoarthritis: a five-year study. J

Rheumatol, 20:461-468, 1993.

25. Ratcliffe A, Azzo W, Lane NE, Mow VC: In vivo effects of naproxen on composition, proteoglycan metabolism and matrix metalloproteinase activities in canine articular cartilage. J Orthopedic Res 11:163-171, 1993.

26. Hagiwara S, Lane NE, Engelke K, Sebastian A, Kimmel DB, Genant HK: Precision and accuracy for rat whole body and femur

bone minerals with dual x-ray absorptiometry. Bone Min Res, 22:57-68, 1993.

27. Maeda H. Kimmel DB, Raab DM, Lane NE. Musculoskeletal recovery following hind limb immobilization in adult female rats, Bone, 14:153-159, 1993.

28. Belmonte-Serrano MA, Bloch DA, Lane NE, Michel B, Fries JF: The relationship between spinal and peripheral osteoarthritis

and bone density measurements. J Rheumatol, 20:1005-1013, 1993.

29. Lane NE, Nevitt M, Genant HK, Hochberg M: Reliability of new indices of the presence and severity of radiographic features of osteoarthritis and lumbar disc degeneration. J. Rheumatol 20(11):1911-1918, 1993.

30. Guilak F, Ratcliffe A, Lane NE, Rosenwasser MP, Mow VC: The tensile modulus, collagen content, and hydroxypyridinium

crosslink density of superficial zone articular cartilage are decreased in canine experimental osteoarthritis. J Ortho Res 12:474-484, 1994.

31. Lane NE, Maeda HJ, Raab DM, Kimmel DB: Effect of naproxen on immobilization-induced cancellous bone loss in the adult

female rat. Bone Min 26:43-59, 1994.

32. Wong S, Lane NE: Statistical quality control in a multicenter clinical trial, Case Studies in Biometry, volume 10 (1):339-356, 1994.

33. Lane NE, Nevitt MC Nevitt MC. Osteoarthritis and bone mass. J Rheumatol. 1994 Aug;21(8):1393-6.

34. Fries JF, Singh G, Morfeld D, Hubert HB, Lane NE, Brown BW Jr. Running and the development of disability with age. Ann

Intern Med. 1994 Oct 1;121(7):502-9.

35. Lane NE. Exercise: a cause of osteoarthritis. J Rheumatol Suppl. 1995 Feb;43:3-6. Review.

36. Kinney JH, Lane NE, Haupt DL. In vivo, three-dimensional microscopy of trabecular bone. J Bone Miner Res. 1995 Feb;10(2):264-70.

37. Lane NE, Pressman AR, Star VC, et al: Rheumatoid arthritis and bone mineral density in elderly women. J Bone Min Res10:257-263, 1995.

38. Gramas D, Antunian FS, Peterfy C, Lane NE: The diagnostic accuracy of physical examination, needle arthroscopy, standard

arthroscopy and MRI for non-acute knee pain: a pilot study. J Clin Rheumatol 1(1):26-34, 1995.

39. Smith RL, Kagiyama G, Lane NE: The effects of nonsteroidal anti-inflammatory drugs on normal human cartilage metabolism. J. Rheumatol 22(6):1130-1137, 1995.

40. Nevitt MC, Cummings SR, Lane NE, et al: Osteoarthritis and osteoporosis in elderly women. Arthritis Rheum 38:907-916,

1995.

41. Nevitt MC, Lane NE, Scott JC, Hochberg MC, Pressman AR, Genant HK, Cummings SR. Radiographic osteoarthritis of the hip and bone mineral density. The Study of Osteoporotic Fractures Research Group. Arthritis Rheum. 1995 Jul;38(7):907-16.

42. Lane NE, Gramas DA. Assessment of needle arthroscopy: comment on the pilot study by gramas et Al. J Clin Rheumatol.

1995 Aug;1(4):255.

35

43. Lane NE, Mroczkowski PJ, Hochberg MC. Prevention and management of glucocorticoid-induced osteoporosis. Bull Rheum Dis. 1995 Aug;44(5):1-4. Review.

44. Hochberg MC, Lane NE, Pressman AR, Genant HK, Scott JC, Nevitt MC. The association of radiographic changes of

osteoarthritis of the hand and hip in elderly women. J Rheumatol. 1995 Dec;22(12):2291-4.

45. Lane NE, Thompson JM, Strewler G, Kinney JH, Intermittent treatment with human parathyroid hormone (hPTH 1-34) increased trabecular bone mass but not connectivity in osteopenic rats. J Bone Min Res 10(10):1470-1477, 1996.

46. Star V, Scott J, Shervin B, Lane NE, et al: Validity of self-reported RA in elderly women. J. Rheumatol 23(11):1862-1865,

1996.

47. Bauer, DC, Orwoll ES, Fox K, Vogt T, Lane NE, Hochberg MC, Stone K, Nevitt MC and the Study of Osteoporotic Fractures Research Group: Aspirin and NSAID Use in Older Women Effect on Bone Mineral Density and Fracture Risk. J Bone Min Res 11(1):29-35, 1996.

48. Lane NE: The risk of osteoarthritis from leisure time activities. Annals of Rheumatic Dis 55(9):632-685, 1996.

49. Lane NE, Kimmel DB, Nilsson MGL, Cohen FE, Newton S, Nissenson RA, Strewler GJ. Bone selective analogues of human PTH

(1-34) increase bone formation in an ovariectomized rat model. J Bone Min Res11(5):614-625,1996.

50. Nevitt MC, Cummings SR, Lane NE, Genant HK, et al: Current use of estrogens is associated with a decreased prevalence of radiographic hip OA in elderly white women. Archives Int Med, 156:2073-2080, 1996.

51. Plesh O, Wolfe F, Lane NE. The prevalence of fibromyalgia and temporomandibular disorders (TMD) in patients with fibromyalgia and TMD. J Rheumatol 23(11):1948-1952, 1996.

52. Segal L, Lane NE. Osteoporosis and systemic lupus erythematosus: etiology and treatment strategies. Ann Med Interne (Paris). 1996;147(4):281-9. Review.

53. Lane NE, Kaneps AJ, Stover SM, Modin G, Kimmel DB. Bone mineral density and turnover following forelimb immobilization

and recovery in young adult dogs. Calcif Tissue Int. 1996 Nov;59(5):401-6.

54. Buckwalter JA, Lane NE. Does participation in sports cause osteoarthritis? Iowa Orthop J. 1997;17:80-9.

55. Lane NE. Aerobic and resistance exercise improved pain and performance in knee osteoarthritis. Evidence Based Med vol. 2(4): 108, 1997

56. Lane NE. Editorial Comment: Primary care management of osteoarthritis. J Musculoskeletal Med vol. 14 (11):4, 1997

57. Long LR, Pillimer S, Goh-G-H, Berman LE, Neve L, Lane NE, Scott W, et al. A digital atlas for spinal X-ray. Proceedings of

Medical Imaging 1997: PACS Design and Evaluation: Engineering and Clinical Issues, SPIE vol. 3035, page 33-38, 1997

58. Segal LG, Lane NE: Controlling steroid osteoporosis. J Musculoskeletal Med 14:43-60, 1997.

59. Lequenue M, Dang N, Lane NE. Sport practice and osteoarthritis of the limbs. Osteoarthritis Cartilage. 1997 Mar;5(2):75-86. Review.

60. Lane NE, Paul RI, Bratcher DF, Stover BH. A survey of policies at children's hospitals regarding immunity of healthcare

workers: are physicians protected? Infect Control Hosp Epidemiol. 1997 Jun;18(6):400-4.

61. Lane NE, Bauer DC, Nevitt MC, Pressman AR, Cummings SR. Aspirin and nonsteroidal antiinflammatory drug use in elderly women: effects on a marker of bone resorption. The Study of Osteoporotic Fractures Research Group. J Rheumatol. 1997 Jun;24(6):1132-6.

62. Lane NE. Pain management in osteoarthritis: the role of COX-2 inhibitors. J Rheumatol Suppl. 1997 Jul;49:20-4. Review.

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63. Lane NE,Nevitt MC, Cooper C, Pressman A, Gore R, Hochberg M. Acetabular dysplasia and osteoarthritis of the hip in elderly white women. Ann Rheum Dis. 1997 Oct;56(10):627-30.

64. Lane NE, Paul RI, Bratcher DF, Stover BH. Pediatric emergency physicians and communicable diseases: can we be trusted to

take care of ourselves? Pediatr Emerg Care. 1997 Oct;13(5):308-11.

65. Hirsch R, Fernandes RJ, Pillemer SR, Hochberg MC, Lane NE, Altman RD, Knowler WC, Bennett PH. Enlarged acetabular labra in the Pima Indians. J Rheumatol. 1997 Nov;24(11):2210-2.

66. Kaneps AJ, Stover SM, Lane NE. Changes in canine cortical and cancellous bone mechanical properties following

immobilization and remobilization with exercise. Bone. 1997 Nov;21(5):419-23.

67. Thompson JM, Modin GW, Arnaud CD, Lane NE. Not all postmenopausal women on chronic steroid and estrogen treatment are osteoporotic: predictors of bone mineral density. Calcif Tissue Int. 1997 Nov;61(5):377-81.

68. Buckwalter JA, Lane NE. Athletics and osteoarthritis. Am J Sports Med. 1997 Nov-Dec;25(6):873-81. Review.

69. Lane NE, Thompson JM. Management of osteoarthritis in the primary-care setting: an evidence-based approach to

treatment. Am J Med. 1997 Dec 29;103(6A):25S-30S. Review.

70. Hirsch R, Fernandes RJ, Pillemer SR, Hochberg MC, Lane NE, Altman RD, Bloch DA, Knowler WC, Bennett PH. Hip osteoarthritis prevalence estimates by three radiographic scoring systems. Arthritis Rheum. 1998 Feb;41(2):361-8.

71. Lane NE, Oehlert JW, Bloch DA, Fries JF. The relationship of running to osteoarthritis of the knee and hip and bone mineral

density of the lumbar spine: a 9 year longitudinal study. J Rheumatol. 1998 Feb;25(2):334-41.

72. Lane NE, Thompson JM, Haupt D, Kimmel DB, Modin G, Kinney JH. Acute changes in trabecular bone connectivity and osteoclast activity in the ovariectomized rat in vivo. J Bone Miner Res. 1998 Feb;13(2):229-36. Erratum in: J Bone Miner Res 1998 Jul;13(7):1212.

73. Augat P, Fan B, Lane NE, Lang TF, LeHir P, Lu Y, Uffmann M, Genant HK. Assessment of bone mineral at appendicular sites in females with fractures of the proximal femur. Bone. 1998 Apr;22(4):395-402.

74. Lane NE, Goldring SR. Bone loss in rheumatoid arthritis: what role does inflammation play? J Rheumatol. 1998 Jul;25(7):1251-3.

75. Lang TI, Augat P, Lane NE, Genant HK. Trochanteric hip fracture: strong association with spinal trabecular bone mineral density measured with quantitative CT. Radiology. 1998 Nov;209(2):525-30.

76. Lane NE, Sanchez S, Modin G, Genant HK, Pierini E, Arnaud CD. Parathyroid hormone treatment can reverse steroid

osteoporosis: Results of a randomized clinical trial. J Clin Invest 102(8):1627-1633, 1998.

77. Link TM, Majumdar S, Augat P, Lin JC, Newitt D, Lu Y, Lane NE, Genant HK. In vivo high resolution MRI of the calcaneus: Differences in trabecular structure in osteoporosis patients. J Bone Min Res 13(7):1175-1182, 1998

78. Link TM, Majumdar S, Augat P, Lin JC, Newitt D, Lane NE, Genant HK. Proximal femur: assessment for osteoporosis with T2*

decay characteristics at MR imaging. Radiology 209(2):531-536, 1998.

79. Hunder G, Kaye R, Lane NE. Rheumatoid arthritis: Progress in research and clinical management. J Musculoskeletal Med 15(11):7-15, 1998

80. Hunder G, Kaye R, Lane NE. Primary care rheumatology, and osteoarthritis now and later. J Musculoskeletal Med 15(9):7-

25, 1998

81. Kinney JH, Ryaby JT, Haupt DL, Lane NE. Three-dimensional in vivo morphometry of trabecular bone in the OVX rat model of osteoporosis. TechnolHealth Care. 1998 Dec;6(5-6):339-50.

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82. Aagaard E, Lim P, Modin G, Lane NE. Prevention of glucocorticoid-induced osteoporosis in an outpatient teaching hospital. Am J Med 107:456-461, 1999.

83. Arden NK, Nevitt MC, Lane NE, Gore LR, Hochberg MC, Scott JC, Pressman AR, Cummings SR. Osteoarthritis and risk of falls,

rates of bone loss, and osteoporotic fractures. Study of Osteoporotic Fractures Research Group. Arthritis Rheum. 1999 Jul;42(7):1378-85.

84. Buckwalter JA, Lane NE. Exercise and risk of osteoarthritis. Am J Medicine Sports. Vol. 6, number 5:228-235, 1999

85. Majumdar S, Link TM, Augat P, Lin JC, Newitt D, Lane NE, Genant HK. Trabecular bone architecture in the distal radius using

magnetic resonance imaging in subjects with fractures of the proximal femur. Magnetic Resonance Science Center and Osteoporosis and Arthritis Research Group. Osteoporos Int. 1999;10(3):231-9.

86. Rehman Q, Lane NE. Getting control of osteoarthritis pain. Postgraduate Medicine. 106(4):127-134, 1999.

87. Lane NE, Haupt D, Kimmel DB, Modin G, Kinney JH. Early estrogen replacement therapy reverses the rapid loss of trabecular bone volume and prevents further deterioration of connectivity in the rat. J Bone Miner Res. 1999Feb;14(2):206-14.

88. Lane NE, Hochberg MC, Pressman A, Scott JC, Nevitt MC. Recreational physical activity and the risk of osteoarthritis of the

hip in elderly women. J Rheumatol. 1999 Apr;26(4):849-54.

89. Lane NE, Gore LR, Cummings SR, Hochberg MC, Scott JC, Williams EN, Nevitt MC. Serum vitamin D levels and incident changes of radiographic hip osteoarthritis: a longitudinal study. Study of Osteoporotic Fractures Research Group. Arthritis Rheum. 1999 May;42(5):854-60.

90. Lane NE, Sanchez S, Jenkins D, Arnaud CD. Short term changes in formation markers predict subsequent spine bone mineral density gains in women with glucocorticoid-induced osteoporosis treated with parathyroid hormone. Osteoporosis Int 11:434-442, 2000.

91. Lane NE, Sanchez S, Modin G, Genant HK, Pierini E, Arnaud CD. Bone mass continues to increase after parathyroid hormone

treatment is stopped in osteoporotic women on low dose corticosteroids and hormone replacement. J Bone Min Res 15(5):944-951, 2000.

92. Lotz J, Kroeber MW, Heilmann M, Pericherla K, Kinney JH, Lane NE. Tibial plateau fracture is a sensitive measure of

estrogen-dependent bone fragility. J Orthopedic Res 18 (2):326-332,2000.

93. Kinney JH, Haupt DL, Witkin D, Ladd AJC, Ryaby JT, Lane NE. Three-dimensional morphometry of the L-6 vertebrae in the ovariectomized rat model of osteoporosis: Biomechanical implications. J Bone Min Res 15(10):1981-1991, 2000.

94. Manek N, Lane NE. Osteoarthritis: Current concepts in diagnosis and management. American Family Physician 61(6):1795-

1804, 2000.

95. Wolfe F, Zhao S, Lane NE. Preference for nonsteroidal anti-inflammatory drugs (NSAIDs) over acetaminophen by rheumatic disease patients: A survey of 1799 patients with osteoarthritis, rheumatoid arthritis, and fibromyalgia. Arthritis Rheum 43(2)378-385, 2000

96. Lane NE, Lane NE, Lin P, Christiansen L, Gore LR, Williams EN, Hochberg MC, Nevitt MC. Association of mild acetabular

dysplasia with an increased risk of incident hip osteoarthritis in elderly white women: the study of osteoporotic fractures. Arthritis Rheum. 2000 Feb;43(2):400-4.

97. Bratcher DF, Stover BH, Lane NE, Paul RI. Compliance with national recommendations for tuberculosis screening and

immunization of healthcare workers in a children's hospital. Infect Control Hosp Epidemiol. 2000 May;21(5):338-40.

98. Adachi J, Saag K, Delmas P, Lieberman U, Emkey R, Seeman E, Lane NE, et al. Two year effects of alendronate on bone mineral density and fracture in patients on glucocorticoids. Arthritis Rheum 44(1):202-211, 2001.

99. Ad hoc committee co-chairperson and co-author for recommendations for the prevention and treatment of glucocorticoid-

induced osteoporosis. Arthritis Rheum 45 (7): 1500-1507, 2001.

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100. Laib A, Kumer JL, Majumdar S, Lane NE. The temporal changes of trabecular architecture in ovariectomized rats assessed by

micro CT. Osteoporosis Int 12:936-941, 2001.

101. Rehman Q, Lane NE. Bone loss. Therapeutic approaches for preventing bone loss in inflammatory arthritis. Arthritis Res. 2001;3(4):221-7. Epub 2001 May 18. Review.

102. Beuf O, Ghosh S, Newitt DC, Link TM, Steinbach L, Ries M, Lane NE, Majumdar S. Magnetic resonance imaging of normal and osteoarthritic bone structure in the knee. Arthritis Rheum 46 (9):385-393, 2002.

103. Srivastav AK, Libanati C, Lane NE, Baylink DJ. Development of a synthetic peptide based tartrate resistant acid phosphatase

radioimmunoassay for the measurement of bone resorption in rat serum. J Bone Min Metab 20:66-72, 2002.

104. Rehman Q, Lang T, Modin G, Lane NE. Quantitative Computed Tomography (QCT), of the lumbar spine, not dual -energy x-ray absorptiometry (DXA) is an independent predictor prevalent vertebral fractures in osteopenic postmenopausal women on chronic glucocorticoid and hormone replacement therapy. Arthritis Rheum 46(5):1292-1297, 2002.

105. Nevitt MC, Xu L, Zhang Y, Lui L-Y, Yu W, Lane NE, Qin M, Hochberg MC, Cummings SR, Felson DT. Very low prevalence of

hip osteoarthritis among Chinese elderly in Beijing compared to Caucasians in the U. S.: The Beijing Osteoarthritis Study, Arthritis Rheum vol 49 (1): 2002.

106. Lane NE, Kumer JL, Majumdar S, Khan M, Lotz J, Stevens RE, Klein R, Phelps KV. The effects of synthetic conjugated

estrogens, a (cenestin) on trabecular bone structure and strength in the ovariectomized rat model. Osteoporos Int. 2002 Oct;13(10):816-23.

107. Wolfe F, Lane NE. The long-term outcome of osteoarthritis: Rates and predictors of joint space narrowing (JSN) in symptomatic patients with knee OA. J Rheumatol 29: 139-146, 2002.

108. Wolfe F, Lane NE, Buckland-Wright C. Radiographic methods in knee OA: A further comparison of semi-flexed (MTP) Schuss-Tunnel and weight-bearing AP views for joint space narrowing and osteophytes. J Rheumatol, 12:2597-601, 2002.

109. Lane NE, Williams E, Hung YY, Hochberg MC, Cummings SR, Nevitt MC. Association of nitrate use with risk of new

radiographic features of hip osteoarthritis in elderly white women. Arthritis Rheum 49 (6) 752-8, 2003.

110. Rehman Q, Lang TF, Arnaud CD, Modin GW, Lane NE. Daily treatment with parathyroid hormone is associated with an increase in vertebral cross-sectional area in postmenopausal women with glucocorticoid-induced osteoporosis. Osteoporos Int. 2003 Jan;14(1):77-81.

111. Link T, Steinbach L, Ghosh S, Ries M, Lu Y, Lane NE, Majumdar S. MR findings in different stages of osteoarthritis and

correlation with clinical findings. Radiology, 226(2):373-81, 2003.

112. Lane NE, Kumer J, Yao W, Breunig T, Wronski T, Modin G, Kinney JH. Basic fibroblast growth factor forms new trabeculae that physically connect with pre-existing trabeculae and this new bone is maintained with an anti-resorptive agent and enhanced with an anabolic agent in an osteopenic rat model. Osteoporosis Int. 14:374-382, 2003.

113. Lane NE, Yao W, Kinney JH, Modin G, Balooch M, Wronski T. Both hPTH (1-34) and bFGF increase trabecular bone mass in

osteopenic rats, however they have different effects on trabecular bone architecture. J Bone Mineral Res, 18 (12) 2105-2115. 2003.

114. Lane NE. Peer-reviewed commentary on preliminary clinical criteria has moderate sensitivity but low specificity for

detecting osteoporosis in rheumatoid arthritis. Evidence Based Medicine May/June 2003.

115. Goemaere S, Liberman U, Adachi J, Hawkins F, Lane NE, Saag K, Schnitzer T, Kaufman J,Malice MP, Carofano W, Daifotis A. Non-vertebral fracture, time on treatment and bone mineral density in glucocorticoid-treated patients: a retrospective study. J Clin Rheumatol 9(3):170-175, 2003.

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116. Humphrey MB, Ogasawara K, Yao W, Spusta SC, Daws MR, Lane NE, Lanier LL, Nakamura MC. The signaling adapter protein DAP-12 regulates multinucleation during osteoclast development. J Bone Miner Res 19 (2): 224-234, 2004.

117. Lane NE, Nevitt MC, Hochberg MC, Hung YY, Palermo L. Progression of radiographic hip osteoarthritis over eight years in a

community sample of elderly white women. Arthritis Rheum. 2004 May;50(5):1477-86.

118. Buxton E, Yao W, Lane NE. Changes in serum receptor activator of nuclear factor-kappaB ligand, osteoprotegerin, and interleukin-6 levels in patients with glucocorticoid-induced osteoporosis treated with human parathyroid hormone (1-34). J Clin Endocrinol Metab. 2004 Jul;89(7):3332-6.

119. Offley SC, Guo TZ, Tzuping, W, Clark JD, Vogel H, Lindsey DP, Jacobs CR, Lane NE, Kingery WS. Capsaicin sensitive sensory neurons contribute to the maintenance of cancellous bone mass, structure, and strength. J Bone Miner Res 20(2):257-267, 2005.

120. Beattie MS, Lane NE, Nevitt MC, Hung YY. Association of statin use and development and progression of hip osteoarthritis in

elderly women. J Rheumatol 32(1): 106-110, 2005.

121. Lian KC, Lang TF, Keyak JH, Modin GW, Rehman Q, Do L, Lane NE. Differences in hip quantitative computed tomography (QCT) measurements of bone mineral density and bone strength between glucocorticoid-treated and glucocorticoid-naive postmenopausal women. Osteoporosis Int.16 (6):642-50, 2005.

122. Lane NE, Yao W, Nakamura MC, Humphrey MD, Kimmel D, Huang X, Sheppard D, Ross FP, Teitelbaum SL. Mice lacking the

integrin beta5 subunit have accelerated osteoclast maturation and increased activity in the estrogen-deficient state. J Bone Miner Res 20(1): 58-66, 2005.

123. Lian K, Zmuda JM, Nevitt MC, Lui L, Hochberg MC, Greene D, Li J, Wang J, Lane NE. Type I collagen alpha1 Sp1 transcription

factor binding site polymorphism is associated with reduced risk of hip osteoarthritis defined by severe joint space narrowing in elderly women. Arthritis Rheum. 52(5):1431-6, 2005.

124. Lane NE, Armitage GC, Loomer P, Hseih S, Majumdar S, Wang HY, Jeffcoat M, Munoz T. Bisphosphonate therapy improves

the outcome of conventional periodontal treatment: Results of a 12-Month, randomized, placebo-controlled study. J Periodontol. 76(7):1113-22,2005.

125. Yao W, Haid T, Jiang Y, Lotz J, Wronski TJ, Lane NE. Basic fibroblast growth factor improves trabecular bone connectivity

and bone strength in the lumbar vertebral body of osteopenic rats. Osteoporosis Int. 16(12):1939-47, 2005.

126. Hurley M, Yao W, Lane NE. Changes in serum fibroblast growth factor 2 in patients with glucocorticoid-induced osteoporosis treated with human parathyroid hormone (1-34). Osteoporosis Int, 16(12):2080-4, 2005.

127. Kinney JH, Stölken JS, Smith TS, Ryaby JT, Lane NE. An orientation distribution function for trabecular bone. Bone. 2005

Feb;36(2):193-201.

128. Lane NE. Performance incentives in the Massachusetts behavioral health program. Adm Policy Ment Health. 2005 Mar;32(4):387-401.

129. Clegg DO, Reda DJ, Harris CL, Klein MA, O'Dell JR, Hooper MM, Bradley JD, Bingham CO 3rd, Weisman MH, Jackson CG, Lane

NE, Cush JJ, Moreland LW, Schumacher HR Jr, Oddis CV, Wolfe F, Molitor JA, Yocum DE, Schnitzer TJ, Furst DE, Sawitzke AD, Shi H, Brandt KD, Moskowitz RW, Williams HJ. Glucosamine, chondroitin sulfate and the two in combination for painful knee osteoarthritis. N Engl J Med; 354(8):795-808,2006.

130. Lane NE, Yao W, Balooch M, Nalla RK, Balooch G, Habelitz S, Kinney JH, Bonewald LF. Glucocorticoid-treated mice have

localized changes in trabecular bone material properties and osteocyte lacunar size that are not observed in placebo-treated or estrogen-deficient mice. J Bone Miner Res; 21(3):466-76, 2006.

131. Lane NE, Lian K, Nevitt MC, Zmuda JM, Lui L, Li J, Wang J, Fontecha M, Umblas N, Rosenbach M, de Leon P, Morr C. Frizzled-

related protein variants are risk factors for hip osteoarthritis. Arthritis Rheum 54 (4): 1246-1254, 2006.

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132. Schwartz AV, Sellmeyer DE, Vittinghoff E, Palermo L, Lecka-Czernik B, Feingold KR, Strotmeyer ES, Resnick HE, Carbone L, Beamer BA, Won Park S, Lane NE, Harris TB, Cummings SR. Thiazolidinedione (TZD) use and bone loss in older diabetic adults. J Clin Endo Metab. 91(9):3349-3354 2006.

133. Yao W, Balooch G, Nalla, Zhou J, Jiang Y, Wronski T, Lane NE. Restoration of cancellous bone connectivity and strength in

ovariectomized mice treated with basic FGF followed by an anti-resorptive agent. Bone 39(3):460-469, 2006.

134. Lane NE. Therapy Insight Review on Osteoporosis and Osteonecrosis in Systemic Lupus Erythematosus. Nature Clinical Rheum Reviews 2(10):562-569, 2006.

135. Faulkner KA, Cauley JA, Zmuda JM, Landsittel DP, Newman AB, Studenski SA, Redfern MS, Ensrud KE, Fink HA, Lane NE,

Nevitt MC. Higher 1,25-dihydroxyvitamin D3 concentrations associated with lower fall rates in older community-dwelling women. Osteoporos Int. 2006;17(9):1318-28.

136. Kelman A, Lui L, Yao W, Krumme A, Nevitt M, Lane NE. Association of higher levels of serum cartilage oligomeric matrix

protein and N-telopeptide crosslinks with the development of radiographic hip osteoarthritis in elderly women. Arthritis Rheum. 2006 Jan;54(1):236-43.

137. Bauer DC, Hunter DJ, Abramson SB, Attur M, Corr M, Felson D, Heinegard D, Jordan JM, Kepler TB, Lane NE, Saxne T, Tyree

B, Kraus VB. Osteoarthritis Biomarkers Network. Classification of osteoarthritis biomarkers: A proposed approach. Osteoarthritis Cartilage. 2006 Aug;14(8):723-7.

138. Lane NE. Does alendronate improve bone mineral density in patients with RA treated with glucocorticoids? Nat Clin Pract Rheumatol. 2006 Aug;2(8):412-3.

139. Lian K, Zmuda JM, Nevitt MC, Lui L, Hochberg MC, Lee JM, Li J, Lane NE. Estrogen Receptor alpha genotypes are Associated

with Reduced Risk of Hip OA in Elderly Women. Osteoarthritis and Cartilage 15(8):972-978, 2007.

140. Lane NE, Nevitt MC, Lui LY, deLeon P, Corr M. Wnt Signaling antagonists as prognostic biomarkers for the progression of radiographic hip osteoarthritis in the study of osteoporotic fractures. Arthritis and Rheumatism 56(10):3319-3325, 2007.

141. Balooch G, Yao W, Balooch M, Nalla RK, Porter AE, Ritchie RO, Lane NE. The aminobisphosphonate risedronate preserves

localized mineral and material properties of bone in the presence of glucocorticoids. Arthritis & Rheum 56(11):3726-3737, 2007.

142. Yao W, Cheng Z, Koester KJ, Ager JW, Chefo S, Balooch G, Balooch M, Pham A, Busse C, Ritchie RO, Lane NE. The degree of

bone mineral is maintained with single intravenous bisphosphonates in aged estrogen deficient rats and is a strong predictor of bone strength. Bone 41(5):804-812, 2007.

143. Wu Y, Tochia J, Yao W, Lane NE, Lanier LL, Nakamura MC, Humphrey MB. Bone microenvironment specific roles of ITAM

adapter signaling during bone remodeling induced by acute estrogen-deficiency. PLoS ONE 2007 4;2:e586.

144. Lane NE. Osteoarthritis of the hip, clinical review, New Engl J Med Oct 4;357(14):1413-1421, 2007.

145. Lane NE. Long-term effects of treatment with alendronate for patients with osteoporosis. Nat Cln Pract Rheumatol 2007 agu;3(8):426-7.

146. Corr M, Lane NE. FRZB: a bone and joint connection. Arthritis Rheum. 2007 Dec;56(12):3881-3.

147. Lane NE, Yao W. Build up bone: current management of osteoporosis. The Rheumatologist volume 1, no.6, 2007, published

by ACR. Page 1.

148. Lane NE, ACP Journal Club comment based on evidence from higher quality trials: Chondroitin does not reduce pain in knee or hip OA. ACP Journal Club, 9/2007.

149. Eckstein F, Buck RJ, Burstein D, Charles C, Crim J, Hudelmaier M, Hunter D, Hutchins G, Jackson C, Kraus VB, Lane NE, Link T,

Majumdar S, Mazzuca S, Prasad PV, Schnitzer TJ, Taljanovic MS, Vax A, Wyman B, LeGraverand MPH. Precision of 3.0 Tesla

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quantitative magnetic resonance imaging of cartilage morphology in a multi-center clinical trial. Precision of 3.0 Ann Rheum Dis. 2008 67(12):1683-1688.

150. Lane NE. Response to Letter in NEJM “Osteoarthritis of the hip” NEJM 358:5 534-535, 2008.

151. Geusens PP, Roux CH, Reid DM, Lems WF, Adami S, Adachi JD, Sambrook PN, Saag KG, Lane NE, Hochberg MC. Drug insight:

choosing a drug treatment strategy for women with osteoporosis - an evidence-based clinical perspective. Nat Clin Pract Rheumatol. 2008 May;4(5):240-8.

152. Chaganti RK. Kelman A, Lui LY, Bauer D, Nevitt MC and Lane NE for Study of Osteoporotic Fractures. The change in serum

measurements of cartilage oligomeric matrix protein is associated with the development and possible prevention of worsening of radiographic hip osteoarthritis. Osteoarthritis and Cartilage 2008 May;16(5):566-71.

153. Cohen SB, Dore RK, Lane NE, Ory P, Peterfy C, Sharp J, van der Heijde D, Zhou F, Tsuju W, Newmark R. Denosumab treatment effects on structural damage, bone mineral density and bone turnover in rheumatoid arthritis: A randomized, double-blind, placebo-controlled clinical trial. Arthritis and Rheumatism, 2008 May;58(5):1299-309.

154. Yao W, Cheng Z, Busse C, Pham A, Nakamura MC, Lane NE. Glucocorticoid excess in mice results in early activation of

osteoclastogenesis and adipogenesis and prolonged suppression of osteogenesis: A longitudinal study of gene expression in bone tissue from glucocorticoid-treated mice. Arthritis Rheum. 2008 June; 58(6):1674-1686.

155. Sawitzke AD, Shi H, Finco M, Dunlop D, Bingham C, Harris C, Singer N, Grau R, Weisman M, Jackson CG, Lane NE, Oddis C, Wolfe F, Lisse J, Furst D, Reda D, Williams HJ, Clegg DO. The effect of glucosamine and/or chondroitin sulfate on the progression of knee osteoarthritis. Arthritis and Rheumatism 2008 Sep 29;58(10):3183-3191.

156. Yu EW, Blackwell T, Ensrud K, Hillier T, Lane NE, Orwoll E, Bauer DC. For the MrOS and SOF Research Groups. Use of acid

suppressive medications and risk of bone loss and fracture in older men and women. Calcif Tiss Int 2008 Oct 83(4):251-9.

157. Yao W, Cheng Z, Pham A, Busse C, Zimmermann EA, Ritchie RO, Lane NE. Glucocorticoid-induced bone loss in mice can be reversed by the actions of parathyroid hormone and risedronate on different pathways for bone formation and mineralization. Arthritis Rheum. 2008 Nov;58(11):3485-97.

158. Ritchie RO, Koester KJ, Ionova S, Yao W, Lane NE, Ager JW. Measurement of toughness of bone: A tutorial with special

reference to small animal studies. Bone 2008 Nov 43(5):798-812.

159. Johnson JA, Yao W, Lane NE, Naquet P, Terkeltaub RA. Vanin-1 pantetheinase drives increased chondrogenic potential of mesenchymal precursors in ank/ank mice. Am J Pathol. 2008 Feb;172(2):440-53.. Epub 2008 Jan 10. Erratum in: Am J Pathol. 2008 Dec;173(6):1929.

160. Shahnazari M, Yao W, Corr M, Lane NE. Targeting the Wnt signaling pathway to augment bone formation. Current

Osteoporosis Reports 2008 Dec:6(4):142-148.

161. Lewiecki EM Lane NE. Common mistakes in the clinical use of bone mineral density testing. Nat Clin Pract Rheumatol. 2008 Dec;4(12):667-74. Epub 2008 Oct 21. Review.

162. Lane NE, Yao W. Developments in the scientific understanding of osteoporosis. Arthritis Res Ther. 2009 19;11(3):228-238.

163. Cheng Z, Yao W, Zimmermann EA, Busse C, Ritchie RO, Lane NE. Prolonged treatments with anti-resorptive agents and PTH

have different effects on bone strength and the degree of mineralization in old estrogen deficient osteoporotic rats. Journal of Bone and Mineral Research 2009: Feb 24(2):209-20.

164. Silverman S and Lane NE. Glucocorticoid Induced Osteoporosis. Current Osteoporosis Reports 2009 Mar; 7(1):23-26.

165. Orwoll ES, Marshall L, Nielson C, Cummings SR, Lapidus J, Cauley JA, Ensrud K, Lane NE, Hoffmann PR, Kopperdahl DA ,

Keaveny TA for the Osteoporotic Fractures in Men (MrOS) Study Group. Finite element analysis of the proximal femur for the prediction of hip fracture in older men. J Bone Miner Res. 2009 Mar 24(3):475-83.

166. Arden NK, Lane NE, Parimi N, Liu L, Hochberg M, Nevitt MC. Defining incident radiographic hip OA for epidemiologic studies

42

in women. Arthritis Rheum 2009 Apr; 60(4): 1052-1059.

167. Lynch JA, Parimi N, Chaganti RK, Nevitt MC, Lane NE. The association of proximal femoral shape and incident radiographic hip OA in elderly women. Osteoarthritis and Cartilage. 2009, 17(10):1313-1318. Epub 2009 Apr 23.

168. Evangelou E, Chapman K, Meulenbelt I, Karissa FB, Loughlin J, Car A, Doherty M, Doherty S, Gomez-Reimo JJ, Gonzalez A,

Halldorsson BV, Hauksson VB, Hofman A, Hart DJ, Ikegawa D, Ingvarsson T, Jiang Q, Jonsdottir I, Jonsson H, Kerkhof HJ, Kloppenburg M, Lane NE, Li J, Lories RJ,. van Meurs JB, Nakki A, Nevitt MC, Rodriguez-Lopez J, Shi J, Slagboom PE, Stefansson K, Tsezou A, Wallis GA, Watson CM, Spector TD, Uitterlinden AG, Valdes AM, Ioannidis JP. Large-scale analysis of association between GDF5 and FRZB variants and osteoarthritis of the hips, knee, and hand. Arthritis Rheum 2009 June:60(6): 1710-1721.

169. Peters JH, Greasby T, Lane NE, Woolf A. Correlations between plasma levels of a fibronectin isoform subpopulation and C-

reactive protein in patients with systemic inflammatory disease. Biomarkers 2009 Jun; 14(4):250-257.

170. Ornetti P, Brandt K, Hello-LeGraverand MP, Hochberg M, Hunter DJ, Kloppenbrug M, Lane NE, Maillefert JF, Mazzuca SA, Spector T, Utard-Wlerick G, Vignon E, Dougados M. OARSI-OMERACT definition of relevant radiological progression in knee/hip osteoarthritis. Osteoarthritis Cartilage 2009 Jul; 17(7):856-63.

171. Javaid MRK, NE, Mackey DC, Lui LY, Arden NK, Beck TJ, Hochberg MC, Nevitt MC. Changes in proximal femoral mineral

geometry precede the onset of radiographic hip osteoarthritis: The study of osteoporotic fractures. Arthritis Rheum. 2009 Jul;60(7):2028-36.

172. Yao W, Cheng ZQ, Pham A, Busse C, Lane NE. Overexpression of secret frizzled-related protein 1 inhibits bone formation

and attenuates PTH bone anabolic effects. Journal Bone Miner Res. 2009 Jul 13.

173. Henley C, Davis J, Miller G, Shatzen E, Cattley R, Li X, Martil D, Yao W, Lane NE, Shalhoub V. The calcimimetic AMG 641 abrogates parathyroid hyperplasia, bone and vascular calcification abnormalities in uremic rats. Eur J Pharmacol. 2009 Aug 15;616(1-3):306-13.

174. Cawthon PM, Ensrud KE, Laughlin GA, Cauley JA, Dam TT, Barrett-Connor E, Fink HA, Hoffman AR, Lau E, Lane NE, Stefanick

ML, Cummings SR, Orwoll ES. Osteoporotic Fractures in Men (MrOS) Research Group. Sex hormones and frailty in older men: The Osteoporotic Fractures in Men (MrOS) Study. J Clin Endocrinol Metab. 2009 Oct;94(10):3806-15

175. Felson D, Gross KD, Nevitt M, Yang M, Lane NE, Torner JC, Lewis CE, Hurley M. The effects of impaired joint position sense on the development and progression of pain and structural damage in knee osteoarthritis. Arthritis & Rheum. 2009 Aug 15;61(8):1070-1076.

176. Tranah GJ, Blackwell T, Parimi N, Ancoli-Isreal S, Ensrud KE, Cauley JA, Redline S, Lane NE, Paudel ML, Hillier TA, Yaffe K,

Cummings SR, Stone KL for the SOF Research Group. Postmenopausal hormones and sleep quality in the elderly: A population based study. BMC Women’s Health 2010, 10:15.

177. Cosman F, Lane NE, Bolognese M, Zanchetta J, Pedro A Garcia-Hernandez, Karen Sees, Kim Gaumer, Peter E Daddona.

Transdermal administration of PTH (1-34): Effects in postmenopausal women with osteoporosis over 6 months. J Clin Endocrinol Metab. 2010 Jan; 95(1):151-8.

178. Andersson N, Strandberg L, Nilsson S, Adamovic S, Karlsson MK, Ljunggren O, Mellström D, Lane NE, Zmuda JM, Nielsen C,

Orwoll E, Lorentzon M, Ohlsson C, Jansson JO. A variant near the interleukin-6 gene is associated with fat mass in Caucasian men. NT J Obes (Lond). 2010 Feb 16: 1-9.

179. Chaganti RK, Parimi N, Cawthon P, Dam T, Nevitt MC, Lane NE. Association of 25-hydroxyvitamin D with prevalent

osteoarthritis of the hip in elderly men: The osteoporotic fractures in men study. Arthritis Rheum. 2010 Feb; 62(2):511-4.

180. Kerkhof, JM, Lories RJ, Meulenbelt I, Johnsdottir I, Valdes A, Arp P, Ingvarsson T, Jhamai M, Jonsson, Stolk L, Thorleifsson G, Zhai G, Zhang F, Zhu Y, van der Breggen R, Carr A, Doherty M, Doherty S, Felson D, Gonzalez A, Halldorsson B, Hart D, Hauksson V, Hofman A, Ioannidis J, Kloppenburg M, Lane NE, Loughlin J, Luyten F, Nevitt M, Parimi N, Pols HAP, van de Putte T, Rivadeneira F, Slagboom EP, Styrkarsdottir U, Tsezou A, Zmuda J, Spector TD, Stefansson K, Uitterlinden A, van

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Meurs JBJ. A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22. Arthritis Rheum. 2010 Feb;62 (2):499-510.

181. Stehling C, Lane NE, Nevitt MC, Lynch J, McCulloch CE, Link TM. Subjects with higher physical activity levels have more

severe focal knee lesions diagnosed with 3T MRI: Analysis of a non-symptomatic cohort of the osteoarthritis initiative. Osteoarthritis Cartilage 2010 Feb 14 (18):776-787.

182. Stehling C, Liebl H, Krug R, Lane NE, Nevitt M, Lynch J, McCulloch C, Link TM. Patellar cartilage: T2 values and morphologic

abnormalities at 3.0-T MR imaging in relation to physical activity in asymptomatic subjects from the osteoarthritis initiative. Radiology. 2010 Feb; 254(2):509-20.

183. Harvey WF, Yang M, Cooke TDV, Segal N, Lane NE, Lewis CE, Felson DT. Association of leg-length inequality with knee

osteoarthritis: A cohort study. Ann Intern Med. 2010 Mar 2; 152(5):287-95.

184. Javaid MK, Lynch JA, Tolstykh I, McCulloch , Guermazi A, Roemer F, Aliabadi P, Curtis J, Felson D, Lane NE, Tomer J, Nevitt M. Pre-radiographic MRI findings are associated with onset of knee symptoms: the most study. Osteoarthritis Cartilage. 2010 Mar; 18(3):323-8.

185. Lane NE, Silverman SL. Anabolic therapies. Curr Osteoporos Rep. 2010 Mar;8(1):23-7.

186. Lane NE, Yao W. Glucocorticoid induced bone fragility: New insights. Proceedings of the New York Academy of Sciences,

Mar 1192(1):81-3, 2010.

187. Dore RK, Cohen SB, Lane NE, Palmer W, Shergy W, Zhou L, Wang H, Tsuji W, Newmark R, Denosumab RA Study Group. Effects of Denosumab on bone mineral density and bone turnover in patients with rheumatoid arthritis receiving concurrent glucocorticoids or bisphosphonates. Ann Rheum Dis. 2010 May;69(5):872-5.

188. Shahnazari M, Yao W, Dai WW, Burghardt AJ, Ionova-Martin S, Limiecik M, Ritchie RO, Heeren D, Wang B, Kimiecik M,

Nicolella D, Lane NE. Higher doses of bisphosphonates further improve bone mass, architecture and strength but not the tissues material properties in aged rats. Bone. 2010 May; 46(5):1267-74.

189. Parimi N, Lane NE, Bauer D, Nevitt MC, Hochberg MC. Accuracy of self-reported diagnosis of hip replacement. (Study of

Osteoporotic Fractures) Arthritis Care Res (Hoboken) 2010 May;62(5):719-24.

190. Finch JL, Tokumoto M, Nakamura H, Yao W, Shahnazari M, Lane NE, Slatopolsky E. Effect of paricalcitol and cinacalcet on serum phosphate, FGF-23, and bone in rats with chronic kidney disease. Am J Physiol Renal Physiol 2010 Jun (298):1315-1322.

191. Chaganti RK, Parimi N, Lang t, Orwoll E, Stefanick ML, Nevitt M, Lane NE. Osteoporotic Fractures in Mend (MrOS) Study

Group. Bone mineral density and prevalent osteoarthritis of the hip in older men for the Osteoporotic Fractures in Men (MrOS) Study Group. Osteoporos Int. 2010 Aug: 21(8):1307-16.

192. Lane NE. Vitamin D and systemic lupus erythematous: Bones, muscles, joints. Current Rheumatology Reports 2010 Aug; 12(4):259-63.

193. Sawitzke AD, Shi H, Finco MF, Dunlop DD, Harris CL, Singer NG, Bradley JD, Silver D, Jackson CG, Lane NE, Oddis CV, Wolfe F, LIsse J, Furst DE, Bingham CO, Redia DJ, Moskowitz RW, Williams HK, Clegg DO. Clinical efficacy and safety of glucosamine, chondroitin sulphate, their combination, celecoxib or placebo taken to treat osteoarthritis of the knee: 2 year results from GAIT. Annals of Rheumatic Diseases Ann Rheum Dis. 2010 Aug; 69(8):1459-64.

194. Lane NE, Schnitzer TJ, Birbara CA, Mokhtarani M, Shelton DL, Smith MD, Brown MT. Tanezumab for the treatment of pain

from osteoarthritis of the knee. N Engl J Med. 2010 Oct 14;363(16):1521-31. Epub 2010 Sep 29.

195. Xia X, Gluhak-Henrich J, Lane NE, Yao W, Bonewald LF, Biswas SK, Lo-WK, Jiang JX. Glucocorticoid induced autophagy in osteocytes. J Bone Miner Res. 2010 Nov; 25(11):2479-88.

196. Yao W, Dai WW, Shahnazari M, Pham A, Chen Z, Chen H, Guan M, Lane NE. Inhibition of the progesterone nuclear receptor

during the bone linear growth phase increases peak bone mass in female mice. PLoS One. 2010 Jul 1; 5(7):e11410.

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197. Baker-Lepain JC, Lane NE. Relationship between joint shape and the development of osteoarthritis. Curr Opin Rheumatol.

2010 Sep; 22(5):538-43. Review.

198. Cawthon PM, Parimi N, Barrett-Connor E, Laughlin GA, Ensrud KE, Hoffman AR, Shikany JM, Cauley JA, Lane NE, Bauer DC, Orwoll ES, Cummings SR; Osteoporotic Fractures in Men (MrOS) Research Group. Serum 25-hydroxyvitamin D, parathyroid hormone, and mortality in older men. J Clin Endocrinol Metab. 2010 Oct;95(10):4625-34.

199. Domino SE, Bodurtha J, Nagel JD; BIRCWH Program Leadership. Interdisciplinary research career development: building interdisciplinary research careers in women's health program best practices. J Womens Health (Larchmt). 2011 ov;20(11):1587-601.

200. Ing SW, Sinnott, LT, Donepudi S, Davies EA, Pelletier RP, Lane NE. Change in bone mineral density at one year following glucocorticoid withdrawal in kidney transplant recipients. Clin Transplant 2011: 25: E113-E123.

201. Peters JH, Grote MN, Lane NE, Maunder RJ. Changes in plasma fibronectin isoform levels predict distinct clinical outcomes

in critically ill patients. Biomark Insights. 2011;6:59-68.

202. Ensrud KE, Blackwell TL, Cauley JA, Cummings SR, Barrett-Connor E, Dam TT, Hoffman AR, Shikany JM, Lane NE, Stefanick ML, Orwoll ES, Cawthon PM; Osteoporotic Fractures in Men Study Group. Circulating 25-hydroxyvitamin D levels and frailty in older men: The Osteoporotic Fractures in Men Study. J Am Geriatr Soc. 2011 Jan; 59(1):101-6.

203. Shahnazari M, Yao W, Panganiban B, Ritchie RO, Hagar Y, Lane NE. Differential maintenance of cortical and cancellous bone strength following discontinuation of bone active agents. J Bone Miner Res. 2011 Mar; 26(3):569-81.

204. Baker-Lepin JB, Luker KR, Lynch JA, Parimi N, Nevitt MC, Lane NE. Active shape modeling of the hip in the prediction of incident hip fracture. J Bone Miner Res. 2011 Mar; 26 (3):468-74. PMID: 20878772; PMCID: PMC3179295.

205. Kerkhof HJ, Meulenbelt I, Akune T, Arden NK, Aromaa A, Bierma-Zeinstra SM, Carr A, Cooper C, Dai J, Doherty M, Doherty

SA, Felson D, Gonzalez A, Gordon A, Harilainen A, Hart DJ, Hauksson VB, Heliovaara M, Hofman A, Ikegawa S, Ingvarsson T, Jiang Q, Jonsson H, Jonsdottir I, Kawaguchi H, Kloppenburg M, Kujala UM, Lane NE, Leino-Arjas P, Lohmander LS, Luyten FP, Malizos KN, Nakajima M, Nevitt MC, Pols HA, Rivadeneira F, Shi D, Slagboom E, Spector TD, Stefansson K, Sudo A, Tamm A, Tamm AE, Tsezou A, Uchida A, Uitterlinden AG, Wilkinson JM, Yoshimura N, Valdes AM, van Meurs JB. Recommendations for standardization and phenotype definitions in genetic studies of osteoarthritis: the TREAT-OA consortium. Osteoarthritis Cartilage. 2011 Mar;19(3):254-64.

206. Lane NE, Brandt, K, Hawker G, Peeva E, Schreyer E, Tsuji W, Hochberg MC. OARSI-FDA Imitative: Defining the disease state of osteoarthritis. Osteoarthritis Cartilage 2011 May; 19(5):478-82.

207. Panoutsopoulou K, Southam L, Elliott KS, Wrayner N, Zhai G, Beazley C, Thorleifsson G, Arden NK, Carr A, Chapman K,

Deloukas P, Doherty M, McCaskie A, Ollier WE, Ralston SH, Spector TD, Valdes AM, Wallis GA, Wilkinson JM, Arden E, Battley K, Blackburn H, Blanco FJ, Bumpstead S, Cupples LA, Day-Williams AG, Dixon K, Doherty SA, Esko T, Evangelou E, Felson D, Gomez-Reino JJ, Gonzalez A, Gordon A, Gwilliam R, Halldorsson BV, Hauksson VB, Hofman A, Hunt SE, Ioannidis JP, Ingvarsson T, Jonsdottir I, Jonsson H, Keen R, Kerkhof HJ, Kloppenburg MG, Koller N, Lakenberg N, Lane NE, Lee AT, Metspalu A, Meulenbelt I, Nevitt MC, O'Neill F, Parimi N, Potter SC, Rego-Perez I, Riancho JA, Sherburn K, Slagboom PE, Stefansson K, Styrkarsdottir U, Sumillera M, Swift D, Thorsteinsdottir U, Tsezou A, Uitterlinden AG, van Meurs JB, Watkins B, Wheeler M, Mitchell S, Zhu Y, Zmuda JM; arcOGEN Consortium, Zeggini E, Loughlin J. Insights into the genetic architecture of osteoarthritis from stage 1 of the arcOGEN study. Ann Rheum Dis. 2011 May;70(5):864-7.

208. Adamopoulos IE, Tessmer M, Chao CC, Adda S, Gorman D, Petro M, Chou CC, Pierce RH, Yao W, Lane NE, Laface D, Bowman

EP. IL-23 is critical for induction of arthritis, osteoclast formation, and maintenance of bone mass. J Immunol. 2011 Jun 15; 187(2):951-9.

209. Schnitzer TJ, Lane NE, Birbara C, Smith MD, Simpson S, Brown MT. Long-term open-label study of Tanezumab for moderate

to severe osteoarthritic knee pain. Osteoarthritis Cartilage. 2011 Jun; 19(6):639-46.

210. Baker-Lepain JC, Nakamura MC, Lane NE. Effects of inflammation on bone: An update. Cur Opin Rheumatology 2011 Jul; 23(4):389-95.

45

211. Lane NE. Osteoporosis: Yesterday, Today and Tomorrow. Rheumatology (Oxford). 2011 Jul; 50(7):1181-3.

212. Wise BL, Felson DT, Clancy M, Niumai J, Neogi T, Lane NE, Hietpas J, Curtis J, Bradley L, James C, Torner JC, Zhang Y.

Consistency of knee pain and risk of knee replacement: The Multicenter Osteoarthritis Study. Rheumatol. 2011 Jul;38(7):1390-5.

213. Ionova-Martin SS, Wade J, Tang S, Shahnazari M, Ager JW, Lane NE, Yao W, Alliston T, Vaisse C, Ritchie RO. Changes in

cortical bone response to high-fat diet from adolescence to adulthood in mice. Osteoporos Int. 2011 Aug;22(8):2283-93.

214. Javaid MK, Prieto-Alhambra D, Lui L, Cawthorn P, Arden NK, Lang T, Lane NE, Orwoll E, Barrett-Conner E, Nevitt MC, Cooper C, Cumming S, for the Osteoporotic Fractures in Men Research Group. Self-reported weight at birth predicts measures of femoral size but not volumetric BMD in elderly men: MROA. J Bone Miner Res. 2011 Aug; 26(8):1802-7/jbmr.411.

215. Chaganti RK, Lane NE. Risk factors for incident osteoarthritis of the hip and knee. Curr Rev Musculoskelet Med. 2011

Sep;4(3):99-104. 216. Jia J, Yao W, Guan M, Dai W, Shahnazari M, Kar R, Bonewald L, Jiang JX, Lane NE. Glucocorticoid dose determined osteocyte

cell fate. FASEB Journal. 2011 Oct; 25(10):3366-76.

217. Lane NE, Leatherdale ST, Ahmed R. Use of nicotine replacement therapy among Canadian youth: data from the 2006-2007 National Youth Smoking Survey. Nicotine Tob Res. 2011 Oct;13(10):1009-14.

218. Haugen IK, Haugen IK, Cotofana S, Englund M, Kvien TK, Dreher D, Nevitt M, Lane NE, Eckstein F; Osteoarthritis Initiative Investigators. Hand joint space narrowing and osteophytes are associated with magnetic resonance imaging-defined knee cartilage thickness and radiographic knee osteoarthritis: data from the Osteoarthritis Initiative. J Rheumatol. 2012 Jan;39(1):161-6.

219. Guan M, Yao W, Liu R, Lam KS, Nolta J, Jia J, Panganiban B, Meng L, Zhou P, Shahnazari M, Ritchie RO, Lane NE. Directing

mesenchymal stem cells to bone to augment bone formation and increase bone mass. Nat Med. 2012 Feb 5;18(3):456-62.

220. Baker-Lepain JC, Baker-Lepain JC, Lynch JA, Parimi N, McCulloch CE, Nevitt MC, Corr M, Lane NE. Variant alleles of the Wnt antagonist FRZB are determinants of hip shape and modify the relationship between hip shape and osteoarthritis. Arthritis Rheum. 2012 May;64(5):1457-65.

221. Wise BL, Niu J, Yang M, Lane NE, Harvey W, Felson DT, Hietpas J, Nevitt M, Sharma L, Torner J, Lewis CE, Zhang Y;

Multicenter Osteoarthritis (MOST) Group. Patterns of compartment involvement in tibiofemoral osteoarthritis in men and women and in whites and African Americans. Arthritis Care Res (Hoboken). 2012 June; 64(6):847-52.

222. Lane NE, Leatherdale ST, Dubin JA, Hammond D. Student and school characteristics associated with use of nicotine

replacement therapy: a multilevel analysis among Canadian youth. Addict Behav. 2012 Jul;37(7):811-6.

223. Parimi N, Blackwell T, Stone KL, Lui LY, Ancoli-Israel S, Tranah GJ, Hillier TA, Nevitt ME, Lane NE; Study of Osteoporotic Fractures Study Group. Hip pain while using lower extremity joints and sleep disturbances in elderly white women: results from a cross-sectional analysis. Arthritis Care Res (Hoboken). 2012 Jul;64(7):1070-8.

224. Baker-Lepain JC, Lane NE. Role of bone architecture and anatomy in osteoarthritis. Bone. 2012 Aug;51(2):197-203.

225. Collette NM, Genetos DC, Economides AN, Xie L, Shahnazari M, Yao W, Lane NE, Harland RM, Loots GG. Targeted deletion

of Sost distal enhancer Increases bone formation and bone mass. Proc Natl Acad Sci USA. 2012 Aug 28; 109(35):14097-7.

226. Zhong Z, Zylstra-Diegel CR, Schumacher CA, Baker JJ, Carpenter AC, Rao S, Yao W, Guan M, Helms JA, Lane NE, Lang RA,

Williams BO. Wntless functions in mature osteoblasts to regulate bone mass. Proc Natl Acad Sci USA 2012 Aug 14; 109(33):E2197-204.

227. Javaid MK, Kiran A, Guermazi A, Kwoh CK, Zaim S, Carbone L, Harris T, McCulloch CE, Arden NK, Lane NE, Felson D, Nevitt M;

Health ABC Study. Individual magnetic resonance imaging and radiographic features of knee osteoarthritis in subjects with unilateral knee pain: The health, aging, and body composition study. Arthritis Rheum. 2012 Oct: 64(10):3246-55.

46

228. Bauer D, Krege J, Lane NE, Leary E, Libanati C, Miller P, Myers G, Silverman S, Vesper HW, Lee D, Payette M, Randall S.

National Bone Health Alliance Bone Turnover Marker Project: Current practices and the need for US harmonization, standardization, and common reference ranges. Osteoporosis Int. 2012 Oct;23(10):2425-33.

229. Baschant U, Lane NE, Tuckermann J. The multiple facets of glucocorticoid action in rheumatoid arthritis. Nat Rev Rheumatol.

2012 Nov;8(11):645-55.

230. Guise JM, Nagel JD, Regensteiner JG, Building Interdisciplinary Research Careers in Women’s Health Directors. Best Practices and Pearls in Interdisciplinary Mentoring from Building Interdisciplinary Research Careers in Women’s Health Directors. J Women’s Health (Larchmt). 2012 Nov;21(11):1114-27.

231. Nardo L, Alizai H, Virayavanich W, Liu F, Hernandez A, Lynch JA, Nevitt MC, McCulloch CE, Lane NE, Link TM. Lumbosacral transitional vertebrae: Association with low back pain. Radiology. 2012 Nov; 265(2): 497-503.

232. Seidel MF, Lane NE. Control of arthritis pain with anti-nerve-growth factor: Risk and benefit. Curr Rheumatol Rep. 2012 Dec; 14(6):583-8.

233. Wise BL, Peloquin C, Choi H, Lane NE, Zhang Y. Impact of Age, Sex, Obesity, and Steroid Use on Quinolone-associated

Tendon Disorders. Am J Med. 2012 Dec; 125(12):1228.e23-1228.e28. PMID: 23026288; PMCID: PMC3502655

234. Jia J, Yao W, Amugongo S, Shahnazari M, Dai W, Lay YE, Olvera D, Cheng Z, Zimmerman E, Ritchie RO, Li C, Alliston T, Lane

NE. Prolonged alendronate treatment prevent the decline in serum TGF-β1 levels and reduces cortical bone strength in long-term estrogen deficiency rat model. Bone. 2013 Jan;52(1):424-32.

235. Lories RJ, Corr M, Lane NE. To Wnt or not to Wnt: the bone and joint health dilemma. Nat Rev Rheumatol. 2013 June;9(6):

328-39.

236. Yao W, Dai W, Jiang JX, Lane NE. Glucocorticoids and osteocyte autophagy. Bone. 2013 Jun; 54(2):279-84.

237. Kraus VB, Feng S, Wang S, White S, Ainslie M, LeGraverand MH, Brett A, Eckstein F, Hunter DJ, Lane NE, Taljanovic MS, Schnitzer T, Charles HC. Subchondral bone trabecular integrity predicts and changes concurrently with radiographic and MRI-determined knee osteoarthritis progression. Arthritis Rheum. 2013 Jul;65(7): 1812-21.

238. Katzman WB, Huang MH, Lane NE, Ensrud KE, Kado DM. Kyphosis and decline in physical function over 15 years in older community-dwelling women: The Study of Osteoporotic Fractures (SOF). Gerontol A Biol Sci Med Sci. 2013 Aug;68(8):976-83.

239. Evangelou E , Kerkhof HJ, Styrkarsdottir U, Ntzani EE, Bos SB, Esko T, Evans DS, Metrustry S, Panoutsopoulou K, Ramos YFM,

Thorleifsson G, Tsilidis KK, arcOGEN Consortium, Arden N, Aslam N, Bellamy N, Birrell F, Blanco FJ, Carr A, Chapman K, Day-Williams AG, Deloukas P, Doherty M, Engström G, Helgadottir HT, Hofman A, Ingvarsson T, Jonsson H, Keis A, Keurentjes JC, Kloppenburg M, Lind PA, McCaskie A, Martin NG, Milani L, Montgomery GW, Nelissen RGHH, Nevitt MC, Nilsson PM, Ollier WER, Parimi N, Rai A, Ralston SH, Reed MR, Riancho JA, Rivadeneira F, Rodriguez-Fontenla C, Southam L, Thorsteinsdottir U, Tsezou A, Wallis GA, Wilkinson JM, Gonzalez A, Lane NE, Lohmander LS, Loughlin J, Metspalu A, Uitterlinden A, Jonsdottir I, Stefansson K, Slagboom PE, Zeggini E, Meulenbelt I, Ioannidis JPA, Spector TD, van Meurs JB, Valdes AM. A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip. Ann Rheum Dis. 2013 Sep 4.

240. Yao W, Guan M, Jia J, Dai W, Lay YA, Amugongo S, Liu R, Olivos D, Saunders M, Lam KS, Nolta J, Olvera D, Ritchie RO, Lane

NE. Reversing bone loss by directing mesenchymal stem cells to bone. Stem Cells. 2013 Sep;331(9);2003-14.

241. Seidel M, Wise B, Lane NE. Nerve Growth Factor: An Update on the Science and Therapy. Osteoarthritis Cartilage. 2013 Sep;21(9):1223-8.

242. Lane NE, Parimi N, Corr M, Yao W, Cauley JA, Nielson CM, Ix JH, Kado D, Orwoll E, for the Osteoporotic Fractures in Men

(MrOS) Study Group. Association of Serum Fibroblast Growth Factor -23 (FGF23) and incident fractures in older men: the Osteoporotic Fractures in Men (MrOS) Study. JBMR 2013 Nov; 28(11):2325-32.

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243. Wise BL, Niu J, Zhang Y, Felson DT, Bradley LA, Segal N, Keysor J, Nevitt M, Lane NE. The association of parity with osteoarthritis and knee replacement in the multicenter Osteoarthritis Study. Osteoarthritis Cartilage. 2013 Dec;21(12):1849-54.

244. Chaudhari AJ, Leahy RM, Wise BL, Lane NE, Badawi RD, Joshi AA. Global point signature for shape analysis of carpal bones.

Phys Med Biol 2014; 59(4): 961-973.

245. Liebl H, Joseph G, Nevitt MC, Singh N, Heilmeier U, Subburaj K, Jungmann PM, McCulloch CE, Lynch JA, Lane NE, Link TM. Early T2 changes predict onset of radiographic knee osteoarthritis: data from the osteoarthritis initiative. Ann Rheum Dis. 2014.

246. Katzman W, Miller-Martinez D, Marshall LM, Lane NE, Kado DM for the Osteoporotic Fractures in Men (MrOS) Research Group. Kyphosis and paraspinal muscle composition in older men: a cross-sectional study for the Osteoporotic Fractures in Men (MrOS) research group. BMC Musculoskelet Disord. 2014 Jan 16;15:19.

247. Nelson AE, Liu F, Lynch JA, Renner JB, Schwartz TA, Lane NE, Jordan JM. Incident symptomatic hip osteoarthritis is

associated with differences in hip shape by active shape modeling: the Johnston County Osteoarthritis Project. Arthritis Care Res 2014 Jan;66(1):74-81.

248. Chaganti RK, Tolstykh L, Javaid MK, Neogi T, Torner J, Curtis J, Jacques P, Felson DT, Lane NE, Nevitt MC for the Multicenter Osteoarthritis Study Group (MOST). High plasma levels of vitamin C and E are associated with incident radiographic knee osteoarthritis. Osteoarthritis Cartilage. 2014 Feb;22(2):190-6.

249. Szulc P, Blackwell T, Schousboe JT, Bauer DC, Cawthon P, Lane NE, Cummings SR, Orwoll ES, Black DM, Ensrud KE. High hip fracture risk in men with severe aortic calcification, MrOS Study. J Bone Miner Res. 2014 Apr;29(4):968-75.

250. Siris ES, Adler R, Bilezikian J, Bolognese M, Dawson-Hughes B, Favus MJ, Harris ST, Jan de Beur SM, Khosla S, Lane NE,

Lindsay R, Nana AD, Orwoll ES, Saag K, Silverman S, Watts NB. The clinical diagnosis of osteoporosis: A position statement from the National Bone Health Alliance Working Group. Osteoporos Int. 2014 May;25(5):1439-43.

251. Smagula SF, Ancoli-Israel S, Barrett-Connor E, Lane NE, Redline S, Stone KL, Cauley JA; Osteoporotic Fractures in Men (MrOS) Research Group. Inflammation, sleep disturbances, and depressed mood among community-dwelling older men. J Psychosom Res. 2014 May;76(5):368-73.

252. Wise BL, Parimi N, Zhang Y, Cawthon PM, Barrett-Connor E, Ensrud K, Lane NE. Frailty and hip osteoarthritis in men in the MrOS cohort. J Gerontol A Biol Sci Med Sci. 2014 May;69(5):602-8.

253. Amugongo SK, Yao W, Jia J, Lay YA, Dai W, Jiang L, Walsh D, Li CS, Dave NK, Olivera D, Panganiban B, Ritchie RO, Lane NE.

Effects of sequential osteoporosis treatments on trabecular bone in adult rats with low bone mass. Osteoporos Int. 2014 Jun;25(6):1735-50.

254. Evans DS, Cailotto F, Parimi N, Valdes AM, Castaño-Betancourt MC, Liu Y, Kaplan RC, Bidlingmaier M, Vasan RS, Teumer A, Tranah GJ, Nevitt MC, Cummings SR, Orwoll ES, Barrett-Connor E, Renner JB, Jordan JM, Doherty M, Doherty SA, Uitterlinden AG, van Meurs JB, Spector TD, Lories RJ, Lane NE. Genome-wide association and functional studies identify a role for IGFBP3 in hip osteoarthritis. Ann Rheum Dis. 2014 Jun 13.

255. Lane NE, Parimi N, Lui L, Wise BL, Yao W, Lay YE, Cawthon PM, Orwoll E for the Osteoporotic Fractures in Men (MrOS) Study Group. Association of serum uric acid and incident fractures in elderly men: the Osteoporotic Fractures in Men (MrOS) Study. J Bone Miner Res. 2014 Jul;29(7):1701-7.

256. Krege JH, Lane NE, Harris JM, Miller PD. PINP as a biological response marker during teriparatide treatment for osteoporosis.

Osteoporos Int. 2014 Sep;25(9):2159-71.

257. Lee TC, Burghardt AJ, Yao W, Lane NE, Majumdar S, Gullberg GT, Seo Y. Improved trabecular bone structure of 20-month-old male spontaneously hypertensive rats. Calcif Tissue Int. 2014 Sep;95(3):282-91.

258. Chaganti RK, Lane NE, Nevitt MC. Response to Letter to the Editor: "Food frequency questionnaire is an effective method for measuring micronutrient intake." Osteoarthritis Cartilage. 2014 Nov;22(11):1949-50.

48

259. Amugongo SK, Yao W, Jia J, Dai W, Lay YA, Jiang L, Harvey D, Zimmermann EA, Schaible E, Dave N, Ritchie RO, Kimmel DB, Lane NE. Effect of sequential treatments with alendronate, parathyroid hormone (1-34) and raloxifene on cortical bone mass and strength in ovariectomized rats. Bone. 2014 Oct;67:257-68.

260. Kim SJ, Chen Z, Chamberlain ND, Essani AB, Volin MV, Amin MA, Volkov S, Gravallese EM, Arami S, Swedler W, Lane NE, Mehta A, Sweiss N, Shahrara S. Ligation of TLR5 Promotes Myeloid Cell Infiltration and Differentiation into Mature Osteoclasts in Rheumatoid Arthritis and Experimental Arthritis. J Immunol. 2014 Oct 15;193(8):3902-13.

261. Nardo L, Lane NE, Parimi N, Cawthon PM, Fan B, Shepherd J, Cauley J, Zucker-Levin A, Murphy RA, Katzman WB. Diffuse Idiopathic Skeletal Hyperostosis Association with Thoracic Spine Kyphosis: A Cross-sectional Study for the Health Aging and Body Composition Study. Spine (Phila Pa 1976). 2014 Nov 15;39(24):E1418-24.

262. Wise BL, Kritikos L, Lynch JA, Liu F, Parimi N, Tileston KL, Nevitt MC, Lane NE. Proximal femur shape differs between subjects with lateral and medial knee osteoarthritis and controls: the Osteoarthritis Initiative. Osteoarthritis Cartilage. 2014 Dec;22(12):2067-73.

263. Pun S, Kumar D, Lane NE. Review: femoroacetabular impingement. Arthritis Rheumatol. 2015 Jan;67(1):17-27.

264. Yao W, Lane NE. Targeted delivery of mesenchymal stem cells to the bone. Bone. 2015 Jan;70:62-5.

265. Massa J, Stone KL, Wei EK, Harrison SL, Barrett-Connor E, Lane NE, Paudel M, Redline S, Ancoli-Israel S, Orwoll E, Schernhammer E. Vitamin D and Actigraphic Sleep Outcomes in Older Community-Dwelling Men: the MrOS Sleep Study. Sleep. 2015 Feb 1;38(2):251-7. PMID: 25581929;

266. Dai W, Jiang L, Lay YA, Chen H, Jin G, Zhang H, Kot A, Ritchie RO, Lane NE, Yao W. Prevention of glucocorticoid induced bone changes with beta-ecdysone. Bone. 2015 May;74:48-57.

267. Jaramillo JD, Wilson C, Stinson DJ, Lynch DA, Bowler RP, Lutz S, Bon JM, Arnold B, McDonald ML, Washko GR, Wan ES, DeMeo DL, Foreman MG, Soler X, Lindsay SE, Lane NE, Genant HK, Silverman EK, Hokanson JE, Make BJ, Crapo JD, Regan EA; COPDGene Investigators. Reduced Bone Density and Vertebral Fractures in Smokers. Men and COPD Patients at Increased Risk. Ann Am Thorac Soc. 2015 May;12(5):648-56.

268. Lane NE, Hochberg MC, Nevitt MC, Simon LS, Nelson AE, Doherty M, Henrotin Y, Flechsenhar K. OARSI Clinical Trials

recommendations: Design and conduct of clinical trials for hip osteoarthritis. Osteoarthritis Cartilage. 2015 May;23(5):761-71. Review. Erratum in: Osteoarthritis Cartilage. 2015 Oct;23(10):1821.

269. Lee S, Nardo L, Kumar D, Wyatt CR, Souza RB, Lynch J, McCulloch CE, Majumdar S, Lane NE, Link TM. Scoring hip

osteoarthritis with MRI (SHOMRI): A whole joint osteoarthritis evaluation system. J Magn Reson Imaging. 2015 Jun;41(6):1549-57.

270. Barbour KE, Lui L, Helmick CG, Murphy LB, Theis KA, Nevitt MC, Lane NE, Hootman JM, Hochberg MC, Cauley JA, Study of Osteoporotic Fractures Research Group. Hip osteoarthritis and the risk of all-cause and disease-specific mortality in older women: population-based cohort study. Arthritis Rheumatol. 2015 Jul;67(7):1798-805.

271. Jungermann, P, Nevitt MC, Baum T, Liebl H, Nardo L, Liu F, Lane NE, McCulloch CE, Link TM. Relationship of unilateral total

hip arthroplasty (THA) to contralateral and ipsilateral knee joint degeneration - a longitudinal 3T MRI study from the Osteoarthritis Initiative (OAI). Osteoarthritis Cartilage. 2015 Jul;23(7):1144-53.

272. Zhong ZA, Sun W, Chen H, Zhang H, Lay YE, Lane NE, Yao W. Optimizing tamoxifen-inducible Cre/loxp system to reduce

tamoxifen effect on bone turnover in long bones of young mice. Bone. 2015 Jul 29. pii: S8756-3282(15)00308-7.

273. Kumar D, Souza RB, Subburaj K, Macleod TD, Nardo L, Link TM, Li X, Lane NE, Majumdar S. Are There Sex Differences in Knee Cartilage Composition and Walking Mechanics in Healthy and Osteoarthritis Populations? Clin Orthop Relat Res. 2015 Aug;473(8):2548-58.

274. Nardo, L, Parimi N, Liu F, Lee S, Jungmann, PM, Nevitt MC, Link TM, Lane NE, for the Osteoporotic Fractures in Men (MrOS)

Research Group. Femoroacetabular Impingement: Prevalent and Often Asymptomatic in Older Men: The Osteoporotic Fractures in Men Study. Clin Orthop Relat Res. 2015 Aug;473(8):2578-86.

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275. Dai W, Zhang H, Zhong ZA, Jiang L, Chen H, Lay YA, Kot A, Ritchie RO, Lane NE, Yao W. β-Ecdysone Augments Peak Bone Mass in Mice of Both Sexes. Clin Orthop Relat Res. 2015 Aug; 473(8):2495-504.

276. Jepsen KJ, Lane NE, Healey JH, Tosi LL. Editorial Comment: Symposium: Sex Differences in Musculoskeletal Disease and

Science. Clin Orthop Relat Res. 2015 Aug;473(8):2474-8.

277. Schousboe JT, Vo T, Taylor BC, Cawthon PM, Schwartz AV, Bauer DC, Orwoll ES, Lane NE, Barrett-Connor E, Ensrud KE, Osteoporotic Fractures in Men (MrOS) Study Research Group. Prediction of Incident Major Osteoporotic and Hip Fractures by Trabecular Bone Score (TBS) and Prevalent Radiographic Vertebral Fracture in Older Men. J Bone Miner Res. 2015 Sep 17.

278. Yu A, Heilmeier U, Kretzschmar M, Joseph GB, Liu F, Liebl H, McCulloch CE, Nevitt MC, Lane NE, Link TM. Racial differences

in biochemical knee cartilage composition between African-American and Caucasian-American women with 3 T MR-based T2 relaxation time measurements - data from the Osteoarthritis Initiative. Osteoarthritis Cartilage. 2015 Sep;23(9):1595-604.

279. Zhong ZA, Sun W, Chen H, Zhang H, Lane NE, Yao W. Inactivation of the Progesterone Receptor in Mx1+ Cells Potentiates

Osteogenesis in Calvaria but Not in Long Bone. PLoS One. 2015 Oct 2;10(10):e0139490. 280. Cawthon PM, Balckwell TL, Cauley J, Kado DM, Barrett-Connor E, Lee CG, Hoffman AR, Stefanick ML, Nevitt M, Lane NE,

Ensrud KE, Cummings SR, Orwoll ES. An evaluation of the usefulness of consensus definition of sarcopenia in older men: The Osteoporotic Fractures in Men (MrOS) Study. J Am Geriatr Soc. 2015 Nov;63(11):2247-59.

281. Lane NE, Maxwell CJ, Gruneir A, Bronskill SE, Wodchis WP. Absence of a Socioeconomic Gradient in Older Adults' Survival

with Multiple Chronic Conditions. EBioMedicine. 2015 Nov 18;2(12):2094-100.

282. Munch T, Harrison SL+, Barrett-Connor E, Lane NE, Nevitt MC, Schousboe JT, Stefanick M, Cawthon PM. Pain and falls and fractures in community dwelling older men. Pain and falls and fractures in community-dwelling older men. Age Ageing. 2015 Nov;44(6):973-9. PMID: 26396181; 27039962

283. An H, Marron JS, Schwartz TA, Renner JB, Liu F, Lynch JA, Lane NE, Jordan JM, Nelson AE. Novel statistical methodology

reveals that hip shape is associated with incident radiographic hip osteoarthritis among African American women. Osteoarthritis Cartilage. 2015 Nov 24.

284. Kim C, Nevitt MC, Niu J, Clancy MM, Lane NE, Link TM, Vlad S, Tolstykh I, Jungmann PM, Felson DT, Guermazi A. Association

of hip pain with radiographic evidence of hip osteoarthritis: diagnostic test study. BMJ. 2015 Dec 2;351:h5983. 285. Krebs EE, Paudel M, Taylor BC, Bauer DC, Fink HA, Lane NE, Ensrud KE; Osteoporotic Fractures in Men (MrOS) Study

Research Group. Association of Opioids with Falls, Fractures, and Physical Performance among Older Men with Persistent Musculoskeletal Pain. J Gen Intern Med. 2016 Jan 11.

286. Gourlay ML, Overman RA, Fine JP, Filteau G, Cawthon PM, Schousboe JT, Orwoll ES, Wilt TJ, Nguyen TV, Lane NE, Szulc P,

Taylor BC, Dam TT, Nielson CM, Cauley JA, Barrett-Connor E, Fink HA, Lapidus JA, Kado DM, Diem S, Ensrud KE, Osteoporotic Fractures in Men (MrOS) Research Group. Time to Osteoporosis and Major Fracture in Men aged 65 Years and Older: the MrOS Study. Am J Prev Med. 2016 Jan 21.

287. Lugo JP, Saiyed ZM, Lane NE. Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee

osteoarthritis symptoms: a multicenter randomized, double-blind, placebo-controlled study. Nutr J. 2016 Jan 29;15(1):14.

288. Yao W, Dai W, Jiang L, Lay EY, Zhong Z, Ritchie RO, Li X, Ke H, Lane NE. Sclerostin-antibody treatment of glucocorticoid-induced osteoporosis maintained bone mass and strength. Osteoporosis Int. 2016 Jan;27(1):283-94.

289. Cawthon PM, Shahnazari M, Orwoll ES, Lane NE. Osteoporosis in men: findings from the Osteoporotic Fractures in Men Study (MrOS). Ther Adv Musculoskelet Dis. 2016 Feb;8(1):15-27.

290. Smagula SF, Stone KL, Redline S, Ancoli-Israel S, Barrett-Connor E, Lane NE, Orwoll ES, Cauley JA; Osteoporotic Fractures in Men (MrOS) Research Group. Actigraphy- and Polysomnography-Measured Sleep Disturbances, Inflammation, and Mortality Among Older Men. Psychosom Med. 2016 Feb 18.

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291. Mohan G, Magnitsky S, Melkus G, Subburaj K, Kazakia G, Burghardt AJ, Dang A, Lane NE, Majumdar S. Kartogenin treatment prevented joint degeneration in a rodent model of osteoarthritis: A pilot study. J Orthop Res. 2016 Feb 19.

292. Nelson AE, Golightly YM, Renner JB, Schwartz TA, Liu F, Lynch JA, Gregory JS, Aspden RM, Lane NE, Jordan JM. Variations in

Hip Shape Are Associated with Radiographic Knee Osteoarthritis: Cross-sectional and Longitudinal Analyses of the Johnston County Osteoarthritis Project. J Rheumatol. 2016 Feb;43(2):405-10.

293. Joseph GB1, Hilton JF, Jungmann PM, Lynch JA, Lane NE, Liu F, McCulloch CE, Tolstykh I, Link TM, Nevitt MC. Do persons

with asymmetric hip pain or radiographic hip OA have worse pain and structure outcomes in the knee opposite the more affected hip? Data from the Osteoarthritis Initiative. Osteoarthritis Cartilage. 2016 Mar;24(3):427-35.

294. Katzman WB, Vittinghoff E, Kado DM, Lane NE, Ensrud KE, Shipp K. Thoracic kyphosis and rate of incident vertebral fractures:

the Fracture Intervention Trial. Osteoporos Int. 2016 Mar;27(3):899-903.

295. Cauley JA, Cawthon PM, Peters KE, Cummings SR, Ensrud KE, Bauer DC, Taylor BC, Shikany JM, Hoffman AR, Lane NE, Kado DM, Stefanick ML, Orwoll ES. Risk Factors for Hip Fracture in Older Men: The Osteoporotic Fractures in Men Study (MrOS). J Bone Miner Res. 2016 Mar 14.

296. Katzman WB, Vittinghoff E, Kado DM, Schafer AL, Wong SS, Gladin A, Lane NE. Study of Hyperkyphosis, Exercise and

Function (SHEAF) Protocol of a Randomized Controlled Trial of Multimodal Spine-Strengthening Exercise in Older Adults With Hyperkyphosis. Phys Ther. 2016 Mar;96(3):371-81.

297. Langsetmo L, Vo TN, Ensrud KE, Taylor BC, Cawthon PM, Schwartz AV, Bauer DC, Orwoll ES, Lane NE, Barrett-Connor E,

Schousboe JT; Osteoporotic Fractures in Men (MrOS) Research Group. The Association Between Trabecular Bone Score and Lumbar Spine Volumetric BMD is Attenuated Among Older Men with High Body Mass Index. J Bone Miner Res. 2016 May 5.

298. Wise BL, Kritikos L, Liu F, Parimi N, Lynch JA, Zhang Y, Lane NE. The association of distal femur and proximal tibia shape with

sex: The Osteoarthritis Initiative. Semin Arthritis Rheum. 2016 Aug;46(1):20. 299. Wise BL, Niu J, Guermazi A, Liu F, Heilmeier U, Ku E, Lynch JA, Zhang Y, Felson DT, Kwoh CK, Lane NE. Magnetic resonance

imaging lesions are more severe and cartilage T2 relaxation time measurements are higher in isolated lateral compartment radiographic knee osteoarthritis than in isolated medial compartment disease - data from the Osteoarthritis Initiative. Osteoarthritis Cartilage. 2016 Aug 15. pii: S1063-4584(16)30232-1.

300. Castaño-Betancourt MC, Evans DS, Ramos YF, Boer CG, Metrustry S, Liu Y, den Hollander W, van Rooij J, Kraus VB, Yau MS,

Mitchell BD, Muir K, Hofman A, Doherty M, Doherty S, Zhang W, Kraaij R, Rivadeneira F, Barrett-Connor E, Maciewicz RA, Arden N, Nelissen RG, Kloppenburg M, Jordan JM, Nevitt MC, Slagboom EP, Hart DJ, Lafeber F, Styrkarsdottir U, Zeggini E, Evangelu E, Spector TD, Uitterlinden AG, Lane NE, Meulenbelt I, Valdes AM, van Meurs JB. Novel Genetic Variants for Cartilage Thickness and Hip Osteoarthritis. PLoS Genet. 2016 Oct 4;12(10):e1006260 eCollection.

301. Yao W, Lay YE, Kot A, Liu R, Zhang H, Chen H, Lam K, Lane NE. Improved Mobilization of Exogenous Mesenchymal Stem Cells

to Bone for Fracture Healing and Sex Difference. Stem Cells. 2016 Oct;34(10):2587-2600.

302. Cauley JA, Kassem A, Lane NE, Thorson S and the Osteoporotic Fractures in Men (MrOS) Study Research Group. Prevalent Peripheral Arterial Disease and Inflammatory Burden. BMC Geriatr. 2016 Dec; 16:213.

303. Lane NE, Corr M. Osteoarthritis in 2016: Anti-NGF treatments for pain – two steps forward, one step back? Nat Rev

Rheumatol. 2017 Jan 25;13(2):76-78. 304. Mohan G, Lay YE, Berka H, Ringwood L, Kot A, Chen H, Yao W, Lane NE. A novel hybrid compound LLP2A-Ale both prevented

and rescued the osteoporotic phenotype in a mouse model of glucocorticoid-induced osteoporosis. Calcif Tissue Int. 2017 Jan;100(1):67-79.

305. Zerbini CAF, Clark P, Mendez-Sanchez L, Pereira RMR, Messina OD, Uña CR, Adachi JD, Lems WF, Cooper C, Lane NE.

Biologic Therapies and Bone Loss in Rheumatoid Arthritis. IOF Chronic Inflammation and Bone Structure (CIBS) Working Group. Osteoporosis Int. 2017 Feb;28(2):429-446.

306. Lane NE, Shidara K, Wise BL. Osteoarthritis Year in Review 2016: Clinical. Osteoarthritis Cartilage. 2017 Feb;25(2):209-215.

51

307. Lane NE, Wodchis WP, Boyd CM, Stukel TA. Disability in long-term care residents explained by prevalent geriatric

syndromes, not long-term care home characteristics: a cross-sectional study. BMC Geriatr. 2017 Feb 10;17(1):49. 308. Hiatt RA, Bailer J, Bascom R, Churchill L, Crump K, Foster Riley M, Briedman DB, Gold D, Goldfrank L, Lane NE, Lippmann M,

Mittleman M, Needleman P, Phale R, Shin H. Controlled Human Inhalation-Exposure Studies at EPA. Committee on Assessing Toxicologic Risks to Human Subjects Used in Controlled Exposure Studies of Environmental Pollutants. The National Academies of Sciences, Engineering, Medicine. March 2017.

309. Mondor L, Maxwell CJ, Hogan DB, Bronskill SE, Gruneir A, Lane NE, Wodchis WP. Multimorbidity and healthcare utilization

among home care clients with dementia in Ontario, Canada: A retrospective analysis of a population-based cohort. PLoS Med. 2017 Mar 7;14(3):e1002249.

310. Rogers TS, Blackwell TL, Lane NE, Tranah G, Orwoll ES, Cauley JA, Ancoli-Israel S, Stone KL, Cummings SR, Cawthon PM. Rest-

activity patterns and falls and fractures in older men. Osteoporos Int. 2017 Apr;28(4):1313-1322.

311. Schousboe J. Schousboe JT, Langsetmo L, Schwartz AV, Taylor BC, Vo TN, Kats AM, Barrett-Connor E, Orwoll ES, Marshall LM, Miljkovic I, Lane NE, Ensrud KE; Osteoporotic Fractures in Men (MrOS) Study Research Group. Comparison of Associations of DXA and CT Visceral Adipose Tissue Measures With Insulin Resistance, Lipid Levels, and Inflammatory Markers. J Clin Densitom. 2017 Apr - Jun;20(2):256-264.

312. Chanchek N, Gersing AS, Schwaiger BJ, Nevitt MC, Joseph GB, Lane NE, Zarnowski J; Facchetti L, Guimaraes JB, McCulloch CE,

Link TM. Association of Diabetes Mellitus and Biochemical Knee Cartilage Composition Assessed by T2 Relaxation Time Measurements: Data from the Osteoarthritis Initiative. J Magn Reson Imaging. 2017 May 26 [Epub ahead of print].

313. Chang RW, Fitzgerald K, Lane NE, Mikdashi J. Peer Reviewers. Treatment of Osteoarthritis of the Knee: An Update Review.

Comparative Effectiveness Review No. 190, Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services. May 2017.

314. Fink HA, Vo TN, Langsetmo L, Barzilay JI, Cauley JA, Schousboe JT, Orwoll ES, Canales MT, Ishani A, Lane NE, Ensrud KE.

Association of Increased Urinary Albumin With Risk of Incident Clinical Fracture and Rate of Hip Bone Loss: the Osteoporotic Fractures in Men Study. J Bone Miner Res. 2017 May;32(5):1090-1099.

315. Lane NE, Corr M, Baer N, Yazici Y. Wnt signaling in osteoarthritis: A 2017 update. Current Treat Options in Rheum, June

2017; (3):101-111.

316. Nielson CM, Wiedrick J, Shen J, Jacobs J, Baker ES, Baraff A, Piehowski P, Lee CG, Baratt A, Petyuk V, McWeeney S, Lim JY, Bauer DC, Lane NE, Cawthon PM, Smith RD, Lapidus J, Orwoll ES; Osteoporotic Fractures in Men (MrOS) Study Research Group. Identification of Hip BMD Loss and Fracture Risk Markers Through Population-Based Serum Proteomics. J Bone Miner Res. 2017 Jul;32(7):1559-1567.

317. Buckley L, Guyatt G, Fink HA, Cannon M, Grossman J, Hansen KE, Humphrey MB, Lane NE, Magrey M, Miller M, Morrison L,

Rao M, Byun Robinson A, Saha S, Wolver S, Bannuru RR, Vaysbrot E, Osani M, Turgunbaev M, Miller AS, McAlindon T. 2017 American College of Rheumatology Guideline for the Prevention and Treatment of Glucocorticoid-Induced Osteoporosis. Arthritis Rheumatol. 2017 Aug;69(8):1521-1537.

318. Cawthon PM, Patel S, Ewing SK, Lui LY, Cauley JA, Lyons JG, Fredman L, Kado DM, Hoffman AR, Lane NE, Ensrud KE,

Cummings SR, Orwoll ES; Osteoporotic Fractures in Men (MrOS) Study Research Group. Bone Loss at the Hip and Subsequent Mortality in Older Men: The Osteoporotic Fractures in Men (MrOS) Study. JBMR Plus. 2017 Aug;1(1):31-35.

319. Katzman WB, Parimi N, Mansoori Z, Nardo L, Kado DM, Cawthon P, Marshall L, Schousboe JT, Lane NE; Osteoporotic

Fractures in Men Study (MrOS) Research Group and the Study of Osteoporotic Fractures. Cross-sectional and Longitudinal Associations of Diffuse Idiopathic Skeletal Hyperostosis (DISH) and Thoracic Kyphosis in Older Men and Women. Arthritis Care Res (Hoboken). 2017 Aug;69(8):1245-1252.

320. Radnovich R, Scott D, Patel AT, Olson R, Dasa V, Segal N, Lane NE, Shrock K, Naranjo J, Darr K, Surowitz R, Choo J, Valadie A,

Harrell R, Wei N, Metyas S. Cryoneurolysis to treat the pain and symptoms of knee osteoarthritis: a multicenter, randomized, double-blind, sham-controlled trial. Osteoarthritis Cartilage. 2017 Aug;25(8):1247-1256.

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321. Buckley L, Guyatt G, Fink HA, Cannon M, Grossman J, Hansen KE, Humphrey MB, Lane NE, Magrey M, Miller M, Morrison L,

Rao M, Robinson AB, Saha S, Wolver S, Bannuru RR, Vaysbrot E, Osani M, Turgunbaev M, Miller AS, McAlindon T. 2017 American College of Rheumatology Guideline for the Prevention and Treatment of Glucocorticoid-Induced Osteoporosis. Arthritis Rheumatol. 2017 Aug;69(8):1521-1537.Epub 2017 Jun 6. Review. Erratum in: Arthritis Rheumatol. 2017 Nov;69(11):2246.

322. Zhong ZA, Kot A, Lay YE, Zhang H, Jia J, Lane NE, Yao W. Sex-Dependent, Osteoblast Stage-Specific Effects of Progesterone

Receptor on Bone Acquisition. J Bone Miner Res, Sept 2017;32(9):1841-1852. 323. Deshmukh V, Hu H, Barroga C, Bossard C, Kc S, Dellamary L, Stewart J, Chiu K, Ibanez M, Seo T, Do L , Cho S, Cahiwat J, Tam

B, Tabmiah JRS, Hood J, Lane NE, Yazici Y. A Small-Molecule Inhibitor of the Wnt Pathway (SM04690) as a Potential Disease Modifying Agent for the Treatment of Osteoarthritis of the Knee. Osteoarthritis Cartilage, Sept 2017 [Epub ahead of print] .

324. Langsetmo L, Kats AM, Cawthon PM, Cauley JA, Vo TN, Taylor BC, Stefanick ML, Lane NE, Stone KL, Orwoll ES, Schousboe JT,

Ensrud KE; Osteoporotic Fractures in Men (MrOS) Study Group. The Association Between Objectively Measured Physical Activity and Subsequent Health Care Utilization in Older Men. J Gerontol A Biol Sci Med Sci. 2017 Oct 9. [Epub ahead of print].

325. Gourlay ML, Ritter VS, Fine JP, Overman RA, Schousboe JT, Cawthon PM, Orwoll ES, Nguyen TV, Lane NE, Cummings SR,

Kado DM, Lapidus JA, Diem SJ, Ensrud KE; Osteoporotic Fractures in Men (MrOS) Study Group. Comparison of fracture risk assessment tools in older men without prior hip or spine fracture: the MrOS study. Arch Osteoporos. 2017 Oct 20;12(1):91.

326. Katzman WB, Vittinghoff E, Lin F, Schafer A, Long RK, Wong S, Gladin A, Fan B, Allaire B, Kado DM, Lane NE. Targeted spine

strengthening exercise and posture training program to reduce hyperkyphosis in older adults: results from the study of hyperkyphosis, exercise, and function (SHEAF) randomized controlled trial. Osteoporos Int. 2017 Oct;28(10):2831-2841.

327. Zhang H, Kot A, Lay YE, Fierro FA, Chen H, Lane NE, Yao W. Acceleration of Fracture Healing by Overexpression of Basic

Fibroblast Growth Factor in the Mesenchymal Stromal Cells. Stem Cells Transl Med, Oct 2017;6(10):1880-1893.

328. Yazici Y, McAlindon TE, Fleischmann R, Gibofsky A, Lane NE, Kivitz AJ, Skrepnik N, Armas E, Swearingen CJ, DiFrancesco A, Tambiah JRS, Hood J, Hochberg MC. A Novel Wnt Pathway Inhibitor, SM04690, for the Treatment of Moderate to Severe Osteoarthritis of the Knee: Results of a 24-Week, Randomized, Controlled, Phase 1 Study. Osteoarthritis Cartilage, Oct 2017;25(10):1598-1601.

329. Kot A, Zhong ZA, Zhang H, Lay YE, Lane NE, Yao W. Sex Dimorphic Regulation of Osteoprogenitor Progesterone in Bone

Stromal Cells. J Mol Endocrinol, Nov 2017;59(4):351-363.

330. Fink HA, Litwack-Harrison S, Ensrud KE, Shen J, Schousboe JT, Cawthon PM, Cauley JA, Lane NE, Taylor BC, Barrett-Connor E, Kado DM, Cummings SR, Marshall LM; Osteoporotic Fractures in Men (MrOS) Study Group. Association of Incident, Clinically Undiagnosed Radiographic Vertebral Fractures With Follow-Up Back Pain Symptoms in Older Men: the Osteoporotic Fractures in Men (MrOS) Study. Bone Miner Res. 2017 Nov;32(11):2263-2268.

331. Fink, HA, Litwack-Harrison S, Ensrud KE, Shen J, Schousboe JT, Cawthon PM, Cauley JA, Lane NE, Taylor BC, Barrett-Connor E,

Kado DM, Cummings SR, Marshall LM; Osteoporotic Fractures in Men (MrOS) Study Group. Association of Incident, Clinically Undiagnosed Radiographic Vertebral Fractures With Follow-Up Back Pain Symptoms in Older Men: the Osteoporotic Fractures in Men (MrOS) Study. J Bone Miner Res. 2017 Nov;32(11):2263-2268.

332. Pollack LR, Litwack-Harrison S, Cawthon PM, Ensrud K, Lane NE, Barrett-Connor E, Dam TT. Patterns and Predictors of Frailty

Transitions in Older Men: The Osteoporotic Fractures in Men Study. J Am Geriatr Soc. 2017 Nov;65(11):2473-2479.

333. Gourlay ML, Ritter VS, Fine JP, Overman RA, Schousboe JT, Cawthon PM, Orwoll ES, Nguyen TV, Lane NE, Cummings SR, Kado DM, Lapidus JA, Diem SJ, Ensrud KE; Osteoporotic Fractures in Men (MrOS) Study Group. Correction to: Comparison of fracture risk assessment tools in older men without prior hip or spine fracture: the MrOS study. Arch Osteoporos. 2017 Nov 7;12(1):99.

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334. Rogers TS, Harrison S, Swanson C, Cauley JA, Barrett-Connor E, Orwoll E, Stone KL, Lane NE; Osteoporotic Fractures in Men (MrOS) Study Research Group. Rest-activity circadian rhythms and bone mineral density in elderly men. Bone Rep. 2017 Nov 10;7:156-163.

335. Magnitsky S, Zhang J, Idiyatullin D, Mohan G, Garwood M, Lane NE, Majumdar S. Positive contrast from cells labeled with

iron oxide nanoparticles: Quantitationof imaging data. Magn Reson Med. 2017 Nov;78(5):1900-1910. 336. Bagi CM, Berryman ER, Teo S, Lane NE. Oral administration of undenatured native chicken type II collagen (UC-II)

diminished deterioration of articular cartilage in a rat model of osteoarthritis (OA).Osteoarthritis Cartilage. 2017 Dec;25(12):2080-2090.

337. Faber BG, Baird D, Gregson CL, Gregory JS, Barr RJ, Aspden RM, Lynch J, Nevitt MC, Lane NE, Orwoll E, Tobias JH;

Osteoporotic Fractures in Men (MrOS) Study Research Group. DXA-derived hip shape is related to osteoarthritis: findings from in the MrOS cohort. Osteoarthritis Cartilage. 2017 Dec;25(12):2031-2038.

338. Katzman WB, Parimi N, Gladin A, Poltavskiy EA, Schafer AL, Long RK, Fan B, Wong SS, Lane NE. Sex differences in response

to targeted kyphosis specific exercise and posture training in community-dwelling older adults: a randomized controlled trial. BMC Musculoskelet Disord. 2017 Dec 4;18(1):509.

339. Deshmukh V, Hu H, Barroga C, Bossard C, Kc S, Dellamary L, Stewart J, Chiu K, Ibanez M, Pedraza M, Seo T, Do L, Cho S,

Cahiwat J, Tam B, Tambiah JRS, Hood J, Lane NE, Yazici Y. A small-molecule inhibitor of the Wnt pathway (SM04690) as a potential disease modifying agent for the treatment of osteoarthritis of the knee. Osteoarthritis Cartilage. 2018 Jan;26(1):18-27.

340. Stern AR, Yao X, Wang Y, Berhe A, Dallas M, Johnson ML, Yao W, Kimmel DB, Lane NE. Effect of osteoporosis treatment

agents on the cortical bone osteocyte microenvironment in adult estrogen-deficient, osteopenic rats. Bone Rep. 2018 Feb 26;8:115-124. eCollection 2018 Jun.

341. Amano K, Huebner JL, Stabler TV, Tanaka M, McCulloch CE, Lobach I, Lane NE, Kraus VB, Ma CB, Li X. Synovial Fluid Profile at

the Time of Anterior Cruciate Ligament Reconstruction and Its Association With Cartilage Matrix Composition 3 Years After Surgery. Am J Sports Med. 2018 Mar;46(4):890-899.

342. Lane NE. Osteoarthritis: Bisphosphonates and OA - is there a bone and joint connection? Nat Rev Rheumatol. 2018

Apr;14(4):185-186.

343. Kim C, Nevitt M, Guermazi A, Niu J, Clancy M, Tolstykh I, Jungmann PM, Lane NE, Segal NA, Harvey WF, Lewis CE, Felson DT. Leg Length Inequality and Hip Osteoarthritis in the Multicenter Osteoarthritis Study and the Osteoarthritis Initiative. Arthritis Rheumatol. 2018 Apr 26.[Epub ahead of print] .

344. Buehring B, Hansen KE, Lewis BL, Cummings SR, Lane NE, Binkley N, Ensrud KE, Cawthon PM; Osteoporotic Fractures in Men

(MrOS) Study Research Group. J Bone Miner Res. 2018 Apr 27. [Epub ahead of print]

345. Chalhoub D, Boudreau R, Greenspan S, Newman AB, Zmuda J, Frank-Wilson AW, Nagaraj N, Hoffman AR, Lane NE, Stefanick

ML, Barrett-Connor E, Dam T, Cawthon PM, Orwoll ES, Cauley JA; Osteoporotic Fractures in Men (MrOS) Study Research Group. Associations Between Lean Mass, Muscle Strength and Power, and Skeletal Size, Density and Strength in Older Men. J Bone Miner Res. 2018 Apr 27. [Epub ahead of print]

346. Joseph GB, Nevitt MC, McCulloch CE, Neumann J, Lynch JA, Heilmeier U, Lane NE, Link TM. Associations between molecular

biomarkers and MR-based cartilage composition and knee joint morphology: data from the Osteoarthritis Initiative. Osteoarthritis Cartilage. 2018 May 23. pii: S1063-4584(18)31284-6. [Epub ahead of print].

347. Rogers TS, Harrison S, Judd S, Orwoll ES, Marshall LM, Shannon J, Langsetmo L, Lane NE, Shikany JM; Osteoporotic Fractures in Men (MrOS) Study Research Group. Dietary patterns and longitudinal change in hip bone mineral density among older men. Osteoporos Int. 2018 May;29(5):1135-1145.

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348. Dubrovsky AM, Lim MJ, Lane NE. Osteoporosis in Rheumatic Diseases: Anti-rheumatic Drugs and the Skeleton. Calcif Tissue Int. 2018 May;102(5):607-618.

349. Joseph GB, McCulloch CE, Nevitt MC, Neumann J, Gersing AS, Kretzschmar M, Schwaiger BJ, Lynch JA, Heilmeier U, Lane NE, Link TM. Tool for osteoarthritis risk prediction (TOARP) over 8 years using baseline clinical data, X-ray, and MRI: Data from the osteoarthritis initiative. J Magn Reson Imaging. 2018 Jun;47(6):1517-1526.

350. Neumann J, Hofmann FC, Heilmeier U, Ashmeik W, Tang K, Gersing AS, Schwaiger BJ, Nevitt MC, Joseph GB, Lane NE,

McCulloch CE, Link TM. Type 2 diabetes patients have accelerated cartilage matrix degeneration compared to diabetes free controls: data from the Osteoarthritis Initiative. Osteoarthritis Cartilage. 2018 Jun;26(6):751-761.

351. Christiansen BA, Harrison SL, Fink HA, Lane NE; Study of Osteoporotic Fractures Research Group. Incident fracture is

associated with a period of accelerated loss of hip BMD: the Study of Osteoporotic Fractures. Osteoporos Int. 2018 Jul 10.

352. Cosman F, Crittenden DB, Ferrari S, Khan A, Lane NE, Lippuner K, Matsumoto T, Milmont CE, Libanati C, Grauer A. FRAME

Study: The Foundation Effect of Building Bone With 1 Year of Romosozumab Leads to Continued Lower Fracture Risk After Transition to Denosumab. J Bone Miner Res. 2018 Jul;33(7):1219-1226.

353. Ensrud KE, Vo TN, Burghardt AJ, Schousboe JT, Cauley JA, Taylor BC, Hoffman AR, Orwoll ES, Lane NE, Langsetmo L;

Osteoporotic Fractures in Men (MrOS) Research Group. Weight loss in men in late life and bone strength and microarchitecture: a prospective study. Osteoporos Int. 2018 Jul;29(7):1549-1558.

354. Shidara K, Mohan G, Yao W, Lane NE. Strain-specific differences in the development of bone loss and incidence of osteonecrosis following glucocorticoid treatment in two different mouse strains. Journal of Orthopaedic Translation (In press. 7/1/2018)

355. Tara Sheree Rogers; Blackwell, Terri; Yaffe, Kristine; Ancoli-Israel, Sonia; Redline, Susan,M.D.,M.P.H.; Cauley, Jane A; Kristine

E Ensrud MD; Barrett-Connor, Elizabeth; LeBlanc, Erin S; Katie Stone; Nancy Lane; Tranah, Greg. Rest-Activity Rhythms and Cognitive Decline in Older Men: the MrOS Sleep Study. JAGS ( In press, 7/1/2018)

MANUSCRIPTS SUBMITTED FOR PUBLICATION 1. Connolly-Strong E, Perretti M, Böhm M, Lane NE. Assessment of the effects of glucocorticoids and melanocortins in

rheumatoid arthritis. [Submitted to Seminars in Arthritis and Rheumatism] 2. Chanchek N, Gersing AS, Schwaiger BJ, Nevitt MC, Joseph GB, Lane NE, Zarnowski J, Hofmann FC, Hellmeier U, McCulloch CE,

Link TM. Association of Diabetes Mellitus and Biochemical Knee Cartilage Composition Assessed by T2 Relaxation Time Measurements: Data from the Osteoarthritis Initiative. Journal of Magnetic Resonance Imaging

BOOKS 1. Lane, NE. The Osteoporosis Book. Oxford UP: New York, NY October 1998 2. Lane NE, Wallace D. All About Osteoarthritis: The Definitive Resource for Arthritis Patients and Their Families Oxford UP:

New York, NY April 2002

EDITOR, GUEST BOOK AND JOURNAL EDITORSHIPS

ON PUB MED 1. Panush RS. Lane NE. Exercise and the musculoskeletal system. Baillieres Clin Rheumatol. 1994 Feb;8(1):79-102. Review.

2. Lane NE, Guest editor. Osteoporosis, Rheumatic Disease Clinics of North America vol 20, no.3, August 1994

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3. Wolfe F, Lane NE, Guest Editors, Musculoskeletal Disorders and Treatment, Rheumatic Disease Clinics of North America. 22 (3):1996

4. Lane NE, Wolfe F. Musculoskeletal medicine. Introduction. Rheum Dis Clin North Am. 1996 Aug;22(3):xi-xiii.

5. Lane NE, Guest Editor, "Rheumatic and Allergic Issues in AIDS", Journal of Allergy and Clinical Immunology 14 (4)

Winter/Spring 1996/1997

6. Lane NE, Guest editor, Update on Osteoporosis, Rheumatic Disease Clinics of North America volume 27: 1, 2001

7. Mazzantini M, Lane NE, Pincus T, Guest Editors. Clinical and Experimental Rheumatology. Vol 18, No. 5 (Suppl 21), 2000

8. Lane NE and Sambrook P. Osteoporosis and osteoporosis in rheumatic diseases. Mosby/Elsevier, published June 2006

9. Editorial Board. Primer of Metabolic Bone Diseases. 2006, published by ASBMR, Favus editor

10. Guest Editor. Lane EN. Metabolic bone disease. Editor G. Hoffman, In Current Opinion in Rheumatology Vol 20, no.4, July 2008

11. Associate Editor, Science Translational Medicine, 2009-2012

12. Associate Editor, Seminars in Arthritis and Rheumatology, 2010-present

13. Associate Editor, Nature Rheumatology Review, 2010-present 14. Guest co-Editor, Clinical Orthopedics and Related Research, “Sex Differences in Musculoskeletal Diseases across the

Lifespan” 2015

INVITED CHAPTERS AND REVIEWS DUPLICATES

1. Thornhill TS, Shortkoff S, Lane NE, Sledge CB. The implant-bone interface and prosthetic loosening. Effects of NSAIDs on

Bone and Joint Diseases: New Insights. Medical Publishing Enterprises, Fairlawn, NJ, pp 105-107, 1990.

2. Lane NE, Genant HK. Osteoporosis and bone mineral density measurements. Arthritis and Allied Conditions, 12th Edition. (DJ McCarty, W Koopman, Eds), Lea & Febiger, 12th edition, Philadelphia, 1992 pages 133-150.

3. Lane NE, Bauer D. Perioperative considerations in the surgical patient. Orthopedic Update 4, American Academy of

Orthopedic Surgeons, 1993.

4. Panush RS, Hansen CS, Inzinna J, Lane NE, et al. Running and Arthritis: Review and Update. In: Progress in Rheumatology, Volume 5, Tel Aviv, Israel, pp. 67-72, 1993.

5. Lane NE, Buckwalter JA. Exercise: a cause of osteoarthritis? Rheum Dis Clin North Am. 1993 Aug;19(3):617-33. Review.

6. Lane NE. Rheumatic manifestations of HIV disease. The AIDS Knowledge Base. (P Cohen, M Sande, P Volbering, Eds),

Medical Publishing Group, Waltham, Massachusetts, pp. 5.34-5.38, 1994.

7. Springfield SD, Lane NE, Friedlander GE. Molecular and Cellular biology of Inflammation and Neoplasm, in Orthopaedic Basic Science (Sheldon Simon ed.) 2nd Edition. American Academy of Orthopedic Surgeons vol 1:219-276, 1994.

8. Lane NE, Gramas D. Medical Management of Osteoarthritis, in Medical Treatment of the Rheumatic Diseases. Weisman M

and Weinblatt M, 1st edition, 286-311, 1994.

9. Kimmel D, Slovik DM, Lane NE. Current and investigational approaches for reversing established osteoporosis. Rheum Dis Clin North Am. 1994 Aug;20(3):735-58.

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10. Buckwalter J, Lane NE, Gordon S. Exercise: What role in osteoarthritis Osteoarthritic Disorders American Academy of Orthopedic Surgeons, (eds) Kuettner K and Goldberg VM, Chapter 28:405-418,1995

11. Lane NE, Kremer LB. Radiographic indices for osteoarthritis. F Wolfe guest editor, Rheum Dis Clin North Am. 1995

May;21(2):379-94. Review.

12. Lane NE, Ott S. Osteoporosis and Metabolic bone diseases Primer of the Rheumatic Diseases, eds Klippel and Weyand, 11th edition.

13. Lane NE. "Rheumatic and Allergic Manifestations of AIDS" in Journal of Allergy and Clinical Immunology, 1996.

14. Minor M, Lane NE. Recreational exercise in arthritis. Rheum Dis Clin North Am. 1996 Aug;22(3):563-77. Review.

15. Lane NE, Jergus M, Genant HK. Osteoporosis and bone mineral density measurements. Arthritis and Allied Conditions,

13th Edition. (W Koopman, Eds) Lea & Febiger, Philadelphia. 1997, pp. 152-172.

16. Lane NE. Thompson JM, Management of Osteoarthritis in the Primary-Care Setting: An Evidence-Based approach to treatment. Am J Med, Dec 29: 103(6A) 25S-30S, 1997.

17. Lane NE, Nevitt MC. Epidemiology of Osteoporosis. In Klippel J and Dieppe P (eds) Textbook of Rheumatology, 2nd edition,

vol. 2:38.1-38.4, 1998.

18. Hunder GG, Kaye RL, Lane NE. Rheumatoid arthritis: Progress in research and clinical management. Journal of Musculoskeletal Medicine 15(11):22-37, 1998.

19. Mundy G and Lane NE. Bone agents. In Klippel J and Dieppe P (eds) Textbook of Rheumatology, 2nd edition, vol. 2:40.1-

40.8, 1998.

20. Lane NE and Lukert B. The science and therapy of glucocorticoid-induced bone loss. Endocrinol Metab Review. Clin North Am. 1998 Jun;27(2):465-83.

21. Lane NE, Buckwalter JA. Exercise and osteoarthritis. Curr Opin Rheumatol. 1999 Sep;11(5):413-6. Review.

22. Dunlop MB, Lane NE. Osteoporosis: diagnosis, prevention, and treatment of established disease. Bull Rheum Dis.

1999;48(6):1-4. Review.

23. Lane NE, Lukert B. Prevention and treatment of glucocorticoid-induced osteoporosis. Journal of Clinical Rheumatology, 5(5), supplement 1: S16-S22, 1999.

24. Lane NE. HIV disease and arthritis. In The AIDS Knowledge Base, 3rd edition, editors (Cohen, Sande, Volberding),

Lippincott Williams and Wilkins, 1999, 585-594.

25. Cunnane G, Lane NE. Steroid-induced osteoporosis in systemic lupus erythematosus. Rheum Dis Clin North Am. 2000 May;26(2):311-29, vi-vii. Review.

26. Lane NE, Rehman Q. Parathyroid hormone treatment for glucocorticoid-induced osteoporosis. Clinical and Experimental

Rheumatology, 18(5), Suppl. 21:S60-S64,2000.

27. Ratiner B, Lane NE. "Treatment of osteoarthritis of the extremities." in Primary Care Rheumatology, E Harris, Jr. and M. Genovese (ed). W.B. Saunders, pp.333-348, 2000.

28. Manek N and Lane NE. General Aspects of Management of OA. In Osteoarthritis (eds.) Moskowitz, Howell, Altman,

Goldberg, 3rd edition W.B. Saunders, Philadelphia, PA 361-70,2000.

29. Mazzantini M, Lane NE, Pincus T. Rheumatic diseases, glucocorticoid treatment and bone mass: Recent developments, Clinical and Experimental Rheumatology 18(5) Suppl. 21:S2-S3, 2000.

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30. Felson D, Lawrence R, Lawrence RC, Dieppe PA, Hirsch R, Helmick CG, Jordan JM, Kington RS, Lane NE, Nevitt MC, Zhang Y, Sowers M, McAlindon T, Spector TD, Poole AR, Yanovski SZ, Ateshian G, Sharma L, Buckwalter JA, Brandt KD, Fries JF. Osteoarthritis: new insights. Part 1: the disease and its risk factors. Ann Intern Med. 2000 Oct 17;133(8):635-46. Review.

31. Lane NE and Miller P. Clinical Manifestations and Diagnosis of Osteoporosis. Primer of the Rheumatic Diseases 12th

edition, Arthritis Foundation, Atlanta, GA 2001.

32. Wolfe F, Rehman Q, Lane NE, Kremer J. When to add DMARDs in RA, at what disease activity level. J Rheumatol, Supplement 2001.

33. Rouillard S, Lane NE. Hepatic osteodystrophy. Hepatology. 2001 Jan;33(1):301-7. Review.

34. Lane NE. An update on glucocorticoid-induced osteoporosis. Rheum Dis Clin North Am. 2001 Feb;27(1):235-53. Review.

35. Wolfe F, Cush JJ, O'Dell JR, Kavanaugh A, Kremer JM, Lane NE, Moreland LW, Paulus HE, Pincus T, Russell AS, Wilskie KR.

Consensus recommendations for the assessment and treatment of rheumatoid arthritis. J Rheumatol. 2001 Jun;28(6):1423-30. Review.

36. Sambrook PN, Lane NE. Corticosteroid osteoporosis. Best Pract Res Clin Rheumatol. 2001 Jul;15(3):401-13. Review.

37. Wolfe F, Rehman Q, Lane NE, Kremer J. Starting a disease modifying antirheumatic drug or a biologic agent in rheumatoid

arthritis: standards of practice for RA treatment. J Rheumatol. 2001 Jul;28(7):1704-11. Review.

38. Lane, NE as co-author for arthritis sections. Menopause, Core Curriculum Study Guide 2002 Edition, publisher North American Menopause Society.

39. Lane NE, Rehman Q. Osteoporosis in the rheumatic disease patient. Lupus; 11(10):675-9,2002.

40. Lane NE, Nevitt MC. Osteoarthritis, bone mass, and fractures: how are they related? Arthritis Rheum. 2002 Jan;46(1):1-4.

Review.

41. Lane NE, Rehman Q. Osteoporosis in the rheumatic disease patient. Lupus.2002;11(10):675-9. Review.

42. Lane NE, Mundy G, Dequeker J. Bone Structure and Function. In Rheumatology, 3rd edition. Eds MC Hochberg, AJ Silman, JS Smolen, ME Weinblatt, MH Weisman, 2003.

43. Rehman Q, Lane NE. Effect of glucocorticoids on bone density. Med Pediatr Oncol. 2003 Sep;41(3):212-6. Review.

44. Buxton E, Fitzgerald IK, Lane NE. Parathyroid hormone as a treatment of osteoporosis. In Today's Therapeutic Trends. vol.

21, no. 4: 345-372, 2003.

45. Lane NE, Kelman A. A review of anabolic therapies for osteoporosis. Arthritis Res Ther. 2003;5(5):214-22. Epub 2003 Aug 5. Review.

46. Lane NE. Recommendations for the prevention and treatment of glucocorticoid-induced osteoporosis. Bone health and

osteoporosis: A report of the Surgeon General. Department of Health and Human Services. 2004.

47. Schnitzer T, Lane NE. Osteoarthritis. In Goldman and Gussiano. Textbook of Medicine, 2004.

48. Menkes CJ, Lane NE. Are osteophytes good or bad? Osteoarthritis Cartilage. 2004;12 Suppl A:S53-4. Review.

49. Rehman Q, Lane NE. Osteoporosis. In St. Clair M, Pitsetsky D, Haynes B, eds. Rheumatoid Arthritis. Philadelphia, PA: Lippincott, Williams & Wilkins, 2004: 504-516.

50. Lane NE. Parathyroid hormone: evolving therapeutic concepts. Curr Opin Rheumatol. 2004 Jul;16(4):457-63. Review.

51. Lane NE. Invited Book Review for 2nt edition of “Nutritional aspects of osteoporosis”. Editors Burckhardt P, Dawson

Hughes B, Heaney RP. American Journal of Clinical Nutrition. December 2004.

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52. Lane, NE, LeBoff M. Metabolic bone disease. In Harris ED, Budd RC, Genovese MC, Firestein GS, Sargent JS, Sledge CB, eds.

Kelley's Textbook of Rheumatology. 7th ed. Philadelphia, PA: Elsevier, 2005:1473-1492.

53. Lane NE. New observations on bone fragility with glucocorticoid treatment. Results from an in vivo animal model. J Musculoskelet Neuronal Interact. 2005 Oct-Dec;5(4):331-2.

54. Kelman A, Lane NE. The management of secondary osteoporosis. Best Pract Res Clin Rheumatol. 2005 Dec;19(6):1021-37.

Review.

55. Lane NE. Osteoporosis: Is there a rational approach to fracture prevention? Bulletin of the NYU Hospital for Joint Diseases. 64(1 and 2):67-72, 2006.

56. Lane NE. Epidemiology, etiology, and diagnosis of osteoporosis. Am J Obstet Gynecol. 2006 Feb;194(2 Suppl):S3-11. Review.

57. Hamann KL, Lane NE. Parathyroid hormone update. Rheum Dis Clin North Am. 2006 Nov;32(4):703-19. Review.

58. Lane NE, Schnitzer TJ. Osteoarthritis, in Goldman and Ausiello, Cecil Medicine 23, Elsevier publishers, Philadelphia, PA,

chapter 283, 2007.

59. Lane NE, Tosi L. Burden of Musculoskeletal Diseases, Chapter 5 “Osteoporosis and Bone Health” publisher United States Bone and Joint Decade, October 2007.

60. Weng MY, Lane NE. Medication-induced osteoporosis. Curr Osteoporos Rep. 2007 Dec;5(4):139-45. Review.

61. Lane NE, Tosi L, Kaufman J. Osteoporosis and Bone Health. In Burden of Musculoskeletal Diseases, USBJD and AAOS,

February 2008.

62. Lane NE, Altman R. Osteoarthritis: Myths and Pearls. Editor John Stone, Myths and Pearls in Rheumatology. Published 9/2009.

63. Schnitzer T, Lane NE. Osteoarthritis. In Goldman and Ausiello, Cecil Medicine 24, Elsevier publishers, Philadelphia, PA,

chapter 283, 2011. 64. Lane NE. Metabolic Bone Disease. Chapter 101, In Kelley’s Textbook of Rheumatology, 8th ed., Editor Firestein G, et al.

Philadelphia, PA: Elsevier, 2011. 1-21.

65. Schwartz AV and Lane NE. Chapter 32 “Bone and Joint Complications in Diabetes,” Diabetes in America, 3rd ed. National Diabetes Information Clearinghouse 2016.

MASTERS THESIS

1. Lee K. Utilization of fractal analysis to assess periodontal bone mass changes. (2001)

2. Hsieh S. Utilization of fractal analysis to assess the efficacy of bisphosphonates in the adjunctive treatment of chronic periodontitis. (2003)

3. Murray, Mandy, PVM, MPVM. The association with silicon and bone fragility in horses (2009)

4. Wise, Barton. The evaluation of pain descriptors and the association in total knee replacement (October, 2009)

5. Li, Guangyi. Micro architectural alternations in arthritic subchondral bone (July 2015)

ABSTRACTS: (MORE THAN 250)-AVAILABLE UPON REQUEST

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CURRENT EXTRAMURAL RESEARCH FUNDING 1 K12 HD051958 (Gold, E) 09/01/05 – 07/31/2020 NIH: NICHHD Total Costs: $2,499,785 BIRCWH Award: Building Interdisciplinary Careers in Women's Health at UC Davis Role: Program Director 1 P50 AR063043 (Lane, NE) 09/12/12-8/31/19 NIH/NIAMS Total Costs: $6,203,216 Sex Differences in Musculoskeletal Conditions across the Lifespan Overarching goal is to inform and transform preventive efforts and clinical practice in diagnosis and treatment of the musculoskeletal conditions in both sexes and lead to improvements in women’s health. The four projects that compose the Center will conduct critical, innovative research to characterize sex differences in musculoskeletal conditions via: 1) a mechanistic study of sex differences in progesterone receptors that are related to regulation or influence peak bone mass, 2) a prospective clinical cohort study using novel diagnostic technology to examine sex differences in the results of this technology to diagnose carpal tunnel syndrome and sex differences in standard treatments for this condition, 3) an epidemiologic imaging study to assess sex differences in bone shape and the influence of bone shape on the development, severity and prognosis of osteoarthritis of the knee, and 4) a randomized clinical trial of sex differences in response to an exercise intervention for the treatment of kyphosis. Role: Principal Investigator R01 AR064771 (Link, T) 8/01/14-7/31/19 NIH Total Costs: $ 81,130 (sub award) Impact of Weight loss on Knee Joint Biochemical and Structural Degeneration The goal of this project is to determine knee function and structure changes with weight loss. Role: Co-Investigator (subcontractor to UCSF) DR2A-05302 (Lane, NE) 11/01/12-10/31/2020 California Institute for Regenerative Medicine/CIRM Total Costs: $19,999,867 Treatment of osteoporosis with endogenous Mesenchymal stem cells The proposed program will advance development of LLP2A-Ale, a small molecule that directs endogenous mesenchymal stem cells (MSCs) to the bone surface to form new bone, through scale up of manufacturing, nonclinical toxicology and a Phase 1 clinical trial in postmenopausal women and men with osteopenia. In addition to safety and pharmacokinetics, the clinical trial will seek proof of concept through assessment of biochemical markers of bone turnover and imaging studies of bone mineral density (BMD) and bone structure. Role: Co-Principal Investigator U24 DE02914 (Lotz (UCSF)) 03/01/17-02/28/20 NIH Center for Dental, Oral, and Craniofacial Tissue and Organ Regeneration (C‐DOCTOR) This U24 project is stage II (U24) of the UCSF (Dr. Jeffrey Lotz) R34 planning award. The project is to fund a center to support validation, manufacturing, and preclinical testing of tissue engineering and regenerative medicine (TE/RM) therapies and accelerating them to clinical trials. The resource center includes eight sites: UCSF, UCD, UC Berkeley, UCLA, UCS, UCSD, Stanford, and City of Hope and identifies and establishes Specialty Service Groups that will support Interdisciplinary Translational Projects (ITPs) from both public and private sectors. UC Davis will support the U24 ITPs with the Large Animal Service Group, GMP Service Group and the Biomarkers/Histology/Histomorphometry sub-Groups. Role: Principal Investigator (Sub award under UCSF)

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ONGOING PHARMACEUTICAL STUDIES (Selected)

OrthoTrophix 8/23/2017 – Present A Prospective Observational Study to Evaluate Long-term Changes in Cartilage Morphology in Subjects Who Previously Received TPX-100 or Placebo in Study TPX-100-1 for Patellar Osteoarthritis Involving Both Knees Role: Principal Investigator Samumed 5/24/2017 – Present A Phase 2, 24-Week, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Safety and Efficacy of SM04690 for the Treatment of Moderately to Severely Symptomatic Knee Osteoarthritis Role: Principal Investigator Amgen 12/19/2016 – Present A Randomized Withdrawal Double-blind Study of Etanercept Monotherapy Compared to Methotrexate Monotherapy for Maintenance of Remission in Subjects with Rheumatoid Arthritis Role: Principal Investigator Pfizer 8/10/2015 – Present A Phase 3 Randomized, Double-Blind, Active-Controlled, Multicenter Study of the Long-Term Safety and Efficacy of Subcutaneous Administration of Tanezumab in Subjects with Osteoarthritis of the Hip or Knee Role: Principal Investigator Osteoporosis Medical Center (Silverman, S) 06/01/15-12/31/17 A Protocol to Evaluate Prospectively the use of Biochemical Markers (Specifically CTX and P1NP) in the Assessment of the “Off” Effect of Bisphosphonates after Initiation of a “Drug Holiday”. Role: Principal Investigator (sub award-recruiting patients)

PREVIOUS RESEARCH SUPPORT (Selected)

1R13 AR068906 (Lane, NE) 07/01/15-06/30/18 NIH Total Costs: $45,000 Young Investigators Career Science and Mentoring Program (R13) This program provides investigators with tools to obtain funding necessary to carry out clinical research to improve the diagnosis and treatment of individuals with musculoskeletal diseases. The national impact of this young investigators research will be appreciated by musculoskeletal disease patients who will be diagnosed sooner and treated more effectively. Their quality of life will be improved from novel clinical research studies performed by the young investigators in these workshops. Role: Principal Investigator

2R01 AR043052 (Lane, NE) 05/01/95-01/31/18 NIH/NIAMS Total Costs: $3,299,976 3D in vivo morphometry of trabecular microstructure By performing two very large experiments long-term studies using 10-month-old osteopenic rats, we will measure localized microstructural properties and whole bone strength and determine how the localized properties change with different treatment regimens. These preclinical studies will provide data that will guide clinicians in prescribing these bone active agents to maximize bone strength and the durability of their effects Role: Principal Investigator R01 AR061366 (Yao, W) 09/01/12-08/31/17 NIH Directing mesenchymal stem cells to bone to augment bone formation Total Costs: $1,548,021 The goal of this project is to evaluate the efficacy and cell biology for the use of a novel compound alone and with transplanted MSCs to augment fracture healing in a mouse model.

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Role: Co-Investigator R01 AR064771 (Link, T) 8/01/14-7/31/18 NIH Total Costs: $ 81,130 (sub award) Impact of Weight loss on Knee Joint Biochemical and Structural Degeneration The goal of this project is to determine knee function and structure changes with weight loss. Role: Co-Investigator (subcontractor to UCSF) R01 AG041921 (Katzman, W) 07/01/12-06/30/17 NIH Total Costs: $276,001 Study of Hyperkyphosis, Exercise and Function –SHEAF The goals of this project are: (1) to determine if resistance exercise targeting spinal strength improves kyphosis; (2) to determine if such exercise improves physical function; and (3) to determine whether changes in kyphosis, spinal muscle strength, or spinal muscle density predict improvement in physical function. Role: Co-Investigator R34DE025592 (Lotz, JC) 09/01/15-08/31/16 NIH/NIDCR University of California Tissue Regeneration Resource Center (UCTRRC) The overall goal of this R34 grant is to execute a series of Stage 1 planning activities to develop an overall vision, roadmap, organizational structure and operational procedures for a multidisciplinary dental, oral, and craniofacial tissue regeneration consortium. Role: Co-Investigator 1 P50 AR060752 (Lane NE; Majumdar S) 08/01/11-07/31/16 NIH Total Costs: $6,226,492 Translational Studies of Imaging and OA The overall objective is to integrate cutting edge quantitative imaging technologies, link the image derived metrics to joint kinematics, kinetics, patient function, and translate the linkages found to the musculoskeletal clinic, thus affecting patient management and outcome. We lead a combined team that includes orthopedic surgeons, rheumatologists, imaging scientists, bioengineers, physical therapists, epidemiologists, and biologists. This team is built upon the strong foundation of interdisciplinary collaborations between the investigators, with a focus on translational research, and is supported by numerous individual investigator and programmatic grants that have established these collaborative research partnerships between the investigators and the institutions. Role: Co-Principal Investigator HHSN 268201000019C (Nevitt, M) 06/15/11-06/14/15 NHLBI/NIH Total Costs: $364,173 Hip Morphology and Limb Specific Risk Factors for Incident and Progressive Radiographic Hip OA Determine the prevalence, incidences and progression of hip OA in the OAI cohort and then the association with risk factors. Role: Principal Investigator (subcontract to UCSF (Nevitt)) 2K24-AR04884 (Lane, NE) 09/30/02-12/31/15 NIH/NIAMS Total Costs: $775,925 Mid-Career Investigator Award in Patient-Oriented Research (K24) The goal of this award is to mentor young clinical investigators in clinical research of the musculoskeletal system. Role: Principal Investigator Teva Branded Pharmaceutical Products R&D, Inc. 04/07/14-12/31/15 A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Topically Applied TV-45070 (4% and 8% w/w Ointment) in Patients with Primary Osteoarthritis Affecting a Single Knee Role: Principal Investigator

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R01 AG19069 (Nevitt, M) 11/01/09-10/31/15 NIH Total Costs: $389,038 MOST, Multicenter Osteoarthritis Study To evaluate longitudinally the effects of biomechanical factors, bone and structural factors and micronutrient deficiencies on the occurrence and progression of symptomatic radiographic knee OA Role: Co-Investigator 1R13AR060095 (Lane, NE) 08/01/10-07/31/15 NIH Total Costs: $100,000 Young Investigators Career Science and Mentoring Program (R13) This program provides investigators with tools to obtain funding necessary to carry out clinical research to improve the diagnosis and treatment of individuals with musculoskeletal diseases. The national impact of this young investigators research will be appreciated by musculoskeletal disease patients who will be diagnosed sooner and treated more effectively. Their quality of life will be improved from novel clinical research studies performed by the young investigators in these workshops. Role: Principal Investigator NIH (Krug, R) 09/01/09-08/30/14 Total Costs: $51,590 In vivo assessment of Trabecular Microstructure at the Proximal Femur Serve as clinical research mentor in the area of bone biology and bone diseases and will supervise clinical study during the second phase of grant. Review study design and data generated for study. Role: Co-investigator U01 AR059507 (Link, T) 07/01/10-6/30/13 NIH/UCSF T2 Relaxation Time of Knee Cartilage in the OAI Incidence Sub cohort The goals of this study were to compare the prevalence of focal knee abnormalities, the mean cartilage T2 relaxation time, and the spatial distribution of cartilage magnetic resonance (MR) T2 relaxation times between subjects with and without risk factors for Osteoarthritis (OA). Role: Co-investigator (subcontract to UCSF (Link)) Roche Pharmaceuticals, Investigator Initiated Study 6/02/10-11/30/13 The Association of Wnt Signaling Inhibitors with Bone Erosion and Bone Turnover in RA. Assess the potential relationship between novel markers for bone and cartilage homeostasis and the progression of bone erosions in RA patients on tocilizumab with and without methotrexate. Determine if baseline levels of these bone turnover markers are associated with the ability of tocilizumab with and without methotrexate to prevent bone erosions and articular cartilage loss in RA patients. Role: Principal Investigator R01 AR052000-01 A1 (Lane, NE) 08/15/05-07/31/12 NIH Epidemiology and Genetics of hip OA in elderly men. The specific aims of this study are to determine both classic and genetic risk factors for hip OA in elderly men. Role: Principal Investigator K24-AR04884 (Lane, NE) 09/30/02-06/30/09 NIH/NIAMS Mid-Career Investigator Award in Patient-Oriented Research (K24) The goal of this award is to mentor young clinical investigators in clinical research of the musculoskeletal system Role: Principal Investigator Arthritis Investigators Award (Lane, NE) 07/04-06/30/07 Arthritis Foundation of Northern California The association of biochemical markers of cartilage and bone turnover markers with development and progression of hip OA. Role: Principal Investigator U01 AR050901 (Corr) 09/30/03 – 09/29/07

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NIH/NIAMS Osteoarthritis Biomarkers Network The specific aims are to confirm the association of the observed FRZB mutations in a series of female patients with hip OA, to assess the association between the FRZB mutants and increased bone density of these women, and to compare the patterns of expression and the levels of Wnt-inducible proteins in the blood of OA patients with defined FRZB polymorphisms and of controls by SELDI-TOF mass spectrometry and by immunoassay Role: Co-investigator R01 AR50265 (Kwoh) Subcontract/Prime 10/01/03 – 06/30/06 NIH Ethnic Differences in Management of Osteoarthritis The University of California Coordinating Center at San Francisco will serve as a subcontractor and will coordinate the project with the parent Health, Aging and body composition (Health ABC) study Role: Co-investigator R01 DK46661 (Lane, NE) 02/22/95-06/30/04 NIH Natl. Inst. of Diabetes and Digestive and Kidney Diseases Can PTH Reverse Glucocorticoid-Induced Osteoporosis? The major goals of this project are to determine whether daily PTH injections, along with daily oral calcium and vitamin D, will increase bone mass in patients on glucocorticoid therapy. Role: Principal Investigator P60 DE13058 (Damsky) 05/01/99-04/30/04 NIDCR New strategies for enhancing tissue integrity and repair The major goals are to determine if daily PTH injections and a bisphosphonate can reverse mandibular bone loss in chronic periodontitis. Role: Co-investigator R01 AG05407-09 (Cummings) 12/01/96-4/30/00 NIH Fractures in Older Women Role: Co-Investigator 1PO1 AR43584-01A1(Fries) 05/01/96-4/30/01 NIH Toward better outcomes in osteoarthritis Role: Project Principal Investigator R01 AR43804 (Nevitt) 09/01/97-08/30/98 NIH Osteoarthritis in Chinese versus Caucasian population. Role: Co-investigator

1 R01 AF15815-01A2 (Fries) 09/30/00-08/31/02 NIH Study of the Efficacy of Exercise and Musculoskeletal Aging. The major goals of this project are to determine the effect of regular weight-bearing exercise in elderly individuals on the development of osteoarthritis and musculoskeletal disability. Role: Co-investigator 1 R01 AR46905 (Majumdar) 09/01/99-08/31/03 NIH Utilization of MRI to study Osteoarthritis The major goals of this study are to advance the use of MRI to determine the extent of knee OA and how the MRI correlates with the clinical presentation and disability Role: Co-investigator 5-P60-AR20610-11 (Fries) 01/01/92 - 12/31/97 NIH

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The Effect of Running on Musculoskeletal Disability (Osteoarthritis) and Bone Density in a Population Ages 60 to 75. Role: Co-Investigator NAG 9-689 06/01/93-5/30/96 NASA The Effect of Immobilization (Unloading) and Reloading in the subchondral bone in a canine model Role: Co-investigator Lawrence Livermore Laboratories (Kinney) 11/01/93-10/31/95 Non-Invasive Methods to Quantitate Bone Fragility Role: Co-investigator AR-40431 (Nevitt) 06/05/90 - 05/31/94 NIH Osteoarthritis and Osteoporosis in Elderly Women Role: Co-investigator UCSF RREAC Award (Lane) 10/1/92-9/30/94 Can KHCO3 prevent hypoestrogenemic induced bone loss in the ovariectomized rat model? Role: Principal Investigator 5 P60-AR20610-11 (Fries) 01/01/86 - 12/31/90 NIH The Effect of Running on Musculoskeletal Disability (Osteoarthritis) and Bone Density in a Population Ages 60 to 75. Role: Co-investigator NIH 5-RO1-AR38941 (Marcus) 09/01/87-12/31/88 Exercise Intensity and Bone Mass in Young Women Role: Co-Investigator UCSF Affirmative Action Faculty Development Awards 4/01/92-9/30/92 A Small Animal Model for Glucocorticoid-Induced Bone Loss Role: Principal Investigator Arthritis Foundation (Nevitt) 07/01/92-06/30/93 Do Serum Biochemical Markers Separate Osteoarthritis from Osteoporosis? Role: Principal Investigator UCSF Academic Senate 02/01/91-11/01/93 Effect of Etidronate on Glucocorticoid-Induced Osteoporosis in Patients with Rheumatoid Arthritis Role: Principal Investigator

PREVIOUS PHARMACEUTICAL STUDIES Amgen, Inc. 07/03/12-07/31/17 A Randomized, Double-blind, Active-controlled Study to Evaluate the Efficacy and Safety of Denosumab Compared with Risedronate in Glucocorticoid-treated Individuals (AMG-162) Role: Principal Investigator Amgen, Inc. 08/01/12-06/30/16 A Multicenter, International, Randomized, Double-blind, Placebo-controlled, Parallel-group Study to Assess the Efficacy and Safety of Romosozumab Treatment in Postmenopausal Women with Osteoporosis (AMG-785) Role: Principal Investigator OrthoTrophix, Inc. 02/01/14-02/04/16

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A Randomized, Double-blind, Placebo-controlled, Multi-dose Phase 2 Study Evaluating the Safety and Efficacy of Intra-articular Injections of TPX-100 in Subjects with Mild to Moderate Patello-Femoral Osteoarthritis Involving Both Knees Role: Principal Investigator Myoscience, Inc. 01/12/15-12/31/16 A Multi-Center, prospective, double-blind, randomized controlled study to evaluate the effectiveness and safety of the iovera device for the temporary relief of pain associated with knee osteoarthritis. Role: Principal Investigator AbbVie Inc. 06/19/14-06/30/16 A Phase 2a Study Evaluating the Safety, Efficacy, and Pharmacodynamic Effects of ABT-981 in Patients with Knee Osteoarthritis Role: Principal Investigator AbbVie Inc. 09/25/15-04/01/18 A Phase 2a, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study Comparing the Safety and Efficacy of ABT-981 to Placebo in Subjects with Erosive Hand Osteoarthritis Role: Principal Investigator