National Alliance for Medical Image Computing: NamicRandy L. Gollub, MD, PhD
Training Core PI, MGH
This dataset in perspective
MIND Who?
Harvard/Massachusetts General Hospital
MIND MCIC Why?
A federally funded multi-site consortium created to advance our understanding of schizophrenia by supporting the acquisition of clinical, cognitive, genetic, morphometric, diffusion weighted and functional neuroimaging data from schizophrenia patients and matched controls using a common experimental protocol.
National Alliance for Medical Image Computing http://na-mic.org
MIND What?
Reliability n =10 travelers to all 4 sites
Clinical n = 300+ Chronic and First Episode (FE) schizophrenics and matched controls
FE subjects and matched controls have follow-up data at 1 year (n = 46)
National Alliance for Medical Image Computing http://na-mic.org
MIND Reliability
T1, T2, DTI, and 4 fMRI task paradigms
Goal: calibrate for clinical study
National Alliance for Medical Image Computing http://na-mic.org
MIND Reliability DTI
0, 700
Diffusion directions
MIND CICS
Over 300 subjects, Chronic and FE pts with matched controls
National Alliance for Medical Image Computing http://na-mic.org
MIND MCIC DTI
Controls n = 138
MIND CICS DTI
Morphometric Scan parameters
T1 (Coronal, MPRAGE)
T2 (Coronal, TSE)
(MGH)
n/a
n/a
6
n/a
n/a
^FOV can be slid up to 18cm when needed for full brain coverage
*1 NEX scan is performed, evaluated, repeated if necessary
dataspectrumphantom
DataSpectrum Phantom Protocol
T1 (Coronal, MPRAGE)
T2 (Coronal, TSE)
1.5 T (Siemens Sonata) Scan Parameters using CP Head Coil
T1 (Coronal, GRE)
T2 (Coronal, TSE)
Siemens 17cm protocol
T1 (Coronal, MPRAGE)
T2 (Coronal, TSE)
T1 (Coronal, GRE)
T2 (Coronal, TSE)
MIND CICS Preliminary Results
Morrow, et al International Congress on Schizophrenia Research, 2007
Morrow EM, Wallace S, Pacheco J, Bockholt J, White T, Ho B, Kuperberg G, Magnotta V, Lim KO, Seidman L, Goff D, Andreasen N, Schulz C, Fischl B, Gollub RL, Structural brain study across lifetime of schizophrenia using computer automated quantification of subcortical volumes in the MIND multisite study, International Congress on Schizophrenia Research, 2007.
National Alliance for Medical Image Computing http://na-mic.org
Freesurfer
Log normalized volume vs. age
1= Controls, 2= Chronic schizophrenia
Hippocampal volume is lateralized with a right greater than left asymmetry noted within each site. Schizophrenic subjects have comparable hippocampal asymmetry, but, are noted to have consistently smaller hippocampal volumes bilaterally. Further work is needed to discern whether there is an additional age or illness duration effect on hippocampal volume that exceeds the normal age effects.
National Alliance for Medical Image Computing http://na-mic.org
For Marty and Andy with
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