mw (th) ogical process data organized - wiley-vch.de filesupporting information: list of proteins...
TRANSCRIPT
Supp
ortin
g In
form
atio
n: L
ist o
f pro
tein
s ide
ntifi
ed in
DLP
FC w
ith p
I, M
W a
nd b
iolo
gica
l pro
cess
dat
a or
gani
zed
acco
rdin
g pr
otei
ns a
bund
ance
s. Pr
otei
n na
me
Acc
ess
nam
e Pe
ptid
es p
er p
rote
in
pI (t
h)
MW
(th)
B
iolo
gica
l Pro
cess
G
luta
thio
ne p
erox
idas
e 1
GPX
1 12
6.
15
2189
9 A
nti-a
popt
osis
M
itoch
ondr
ial R
ho G
TPas
e 1
RH
OT1
2
5.
87
7078
4 A
popt
osis
Am
phip
hysi
n AM
PH
5 4.
58
7625
7 C
ell c
omm
unic
atio
n ; S
igna
l tra
nsdu
ctio
n
Ann
exin
A6
AN
XA
6 7
5.42
75
873
Cel
l com
mun
icat
ion
; Sig
nal t
rans
duct
ion
Ast
rocy
tic p
hosp
hopr
otei
n P
EA
-15
PE
A15
2
4.93
15
040
Cel
l com
mun
icat
ion
; Sig
nal t
rans
duct
ion
C
alci
um/c
alm
odul
in-d
epen
dent
pro
tein
kin
ase
type
II g
amm
a ch
ain
CAM
K2G
4
7.90
62
609
Cel
l com
mun
icat
ion
; Sig
nal t
rans
duct
ion
C
alci
um-b
indi
ng p
rote
in p
22
CH
P 2
4.98
22
456
Cel
l com
mun
icat
ion
; Sig
nal t
rans
duct
ion
ca
lmod
ulin
C
ALM
1 8
4.09
16
838
Cel
l com
mun
icat
ion
; Sig
nal t
rans
duct
ion
C
alm
odul
in-d
epen
dent
pro
tein
kin
ase
II al
pha
Q7L
DD
5_H
UM
AN
5 6.
61
5408
8 C
ell c
omm
unic
atio
n ; S
igna
l tra
nsdu
ctio
n
Cat
enin
del
ta-2
C
TNN
D2
2 7.
78
1326
56
Cel
l com
mun
icat
ion
; Sig
nal t
rans
duct
ion
C
holin
e tra
nspo
rter-l
ike
prot
ein
2 S
LC44
A2
2
8.93
80
152
Cel
l com
mun
icat
ion
; Sig
nal t
rans
duct
ion
C
onta
ctin
-ass
ocia
ted
prot
ein
1 [P
recu
rsor
] C
NTN
AP1
3 6.
61
1562
67
Cel
l com
mun
icat
ion
; Sig
nal t
rans
duct
ion
D
ensi
ty-r
egul
ated
pro
tein
D
ENR
2
5.21
22
092
Cel
l com
mun
icat
ion
; Sig
nal t
rans
duct
ion
D
isks
larg
e ho
mol
og 4
D
LG4
3 5.
58
8049
5 C
ell c
omm
unic
atio
n ; S
igna
l tra
nsdu
ctio
n D
oubl
ecor
tin a
nd C
aM k
inas
e-lik
e 1
DC
AMKL
1 2
5.52
47
681
Cel
l com
mun
icat
ion
; Sig
nal t
rans
duct
ion
D
ynam
in 1
.- H
omo
sapi
ens
(Hum
an).
DN
M1
10
6.73
97
408
Cel
l com
mun
icat
ion
; Sig
nal t
rans
duct
ion
D
ynam
in-li
ke 1
20 k
Da
prot
ein,
mito
chon
dria
l [P
recu
rsor
] O
PA
1 4
7.87
11
1658
C
ell c
omm
unic
atio
n ; S
igna
l tra
nsdu
ctio
n E
zrin
-radi
xin-
moe
sin-
bind
ing
phos
phop
rote
in 5
0 S
LC9A
3R1
3 5.
55
3886
8 C
ell c
omm
unic
atio
n ; S
igna
l tra
nsdu
ctio
n
G1
to S
pha
se tr
ansi
tion
1 G
SP
T1
2 5.
45
5565
7 C
ell c
omm
unic
atio
n ; S
igna
l tra
nsdu
ctio
n
Gua
nine
nuc
leot
ide-
bind
ing
prot
ein
G(i)
, alp
ha-1
sub
unit
GN
AI1
2
5.69
40
361
Cel
l com
mun
icat
ion
; Sig
nal t
rans
duct
ion
G
uani
ne n
ucle
otid
e-bi
ndin
g pr
otei
n G
(o) s
ubun
it al
pha
1 G
NA
O1
5 5.
34
4005
1 C
ell c
omm
unic
atio
n ; S
igna
l tra
nsdu
ctio
n H
eat s
hock
pro
tein
90k
Da
alph
a (C
ytos
olic
), cl
ass
B m
embe
r 1 [F
ragm
ent]
HS
P90
AB
1
5 4.
98
1913
5 C
ell c
omm
unic
atio
n ; S
igna
l tra
nsdu
ctio
n
Hom
er h
omol
og 1
H
OM
ER1
2
5.33
40
275
Cel
l com
mun
icat
ion
; Sig
nal t
rans
duct
ion
H
orm
onal
ly u
p-re
gula
ted
neu
tum
or-a
ssoc
iate
d ki
nase
H
UN
K 2
9.24
79
686
Cel
l com
mun
icat
ion
; Sig
nal t
rans
duct
ion
IQ m
otif
and
Sec
7 do
mai
n-co
ntai
ning
pro
tein
1
IQS
EC
1 2
6.49
10
8314
C
ell c
omm
unic
atio
n ; S
igna
l tra
nsdu
ctio
n
Leuc
ine
zipp
er-E
F-ha
nd-c
onta
inin
g tra
nsm
embr
ane
prot
ein
1, m
itoch
ondr
ial [
Pre
curs
or]
LETM
1 4
6.30
83
354
Cel
l com
mun
icat
ion
; Sig
nal t
rans
duct
ion
Li
n-7
hom
olog
C
LIN
7C
2 8.
52
2183
4 C
ell c
omm
unic
atio
n ; S
igna
l tra
nsdu
ctio
n
Mel
aton
in re
cept
or M
EL1
B [F
ragm
ent
MTN
R1B
2
9.54
14
649
Cel
l com
mun
icat
ion
; Sig
nal t
rans
duct
ion
N
eura
bin-
2 P
PP
1R9B
2
4.91
89
192
Cel
l com
mun
icat
ion
; Sig
nal t
rans
duct
ion
N
eura
l cel
l adh
esio
n m
olec
ule
1 N
CAM
1 7
4.77
83
770
Cel
l com
mun
icat
ion
; Sig
nal t
rans
duct
ion
N
euro
fasc
in [P
recu
rsor
] N
FASC
7
6.24
15
0027
C
ell c
omm
unic
atio
n ; S
igna
l tra
nsdu
ctio
n
Neu
rogr
anin
N
RG
N
3 7.
72
7618
C
ell c
omm
unic
atio
n ; S
igna
l tra
nsdu
ctio
n
Neu
rona
l cal
cium
sen
sor 1
FR
EQ
2 4.
71
2187
9 C
ell c
omm
unic
atio
n ; S
igna
l tra
nsdu
ctio
n N
ucle
ar m
igra
tion
prot
ein
nudC
N
UD
C
2 5.
27
3824
3 C
ell c
omm
unic
atio
n ; S
igna
l tra
nsdu
ctio
n
Pep
tidyl
-pro
lyl c
is-tr
ans
isom
eras
e FK
BP
10
3 5.
36
6424
5 C
ell c
omm
unic
atio
n ; S
igna
l tra
nsdu
ctio
n
Pho
spha
tidyl
etha
nola
min
e-bi
ndin
g pr
otei
n 1
PE
BP
1 19
7.
01
2105
7 C
ell c
omm
unic
atio
n ; S
igna
l tra
nsdu
ctio
n
Ple
xin-
B3
[Pre
curs
or]
PLX
NB3
2
5.96
20
6847
C
ell c
omm
unic
atio
n ; S
igna
l tra
nsdu
ctio
n
Pro
hibi
tin
PH
B
4 5.
57
2983
2 C
ell c
omm
unic
atio
n ; S
igna
l tra
nsdu
ctio
n
Pro
tein
kin
ase
C a
nd c
asei
n ki
nase
sub
stra
te in
neu
rons
1
PA
CS
IN1
8 5.
26
4614
6 C
ell c
omm
unic
atio
n ; S
igna
l tra
nsdu
ctio
n
Pro
tein
kin
ase
C g
amm
a ty
pe
PRKC
G
3 7.
27
7844
8 C
ell c
omm
unic
atio
n ; S
igna
l tra
nsdu
ctio
n P
rote
in N
ipS
nap2
G
BA
S
2 9.
42
3374
3 C
ell c
omm
unic
atio
n ; S
igna
l tra
nsdu
ctio
n
Sep
tin-7
S
EP
T7
2 8.
76
5068
0 C
ell c
omm
unic
atio
n ; S
igna
l tra
nsdu
ctio
n
Ser
ine/
thre
onin
e-pr
otei
n ph
osph
atas
e 2B
cat
alyt
ic s
ubun
it al
pha
isof
orm
P
PP
3CA
6
5.58
58
688
Cel
l com
mun
icat
ion
; Sig
nal t
rans
duct
ion
Sig
nal r
egul
ator
y pr
otei
n be
ta-1
[Pre
curs
or]
SIR
PB
1 5
6.06
43
255
Cel
l com
mun
icat
ion
; Sig
nal t
rans
duct
ion
S
RG
AP
3 pr
otei
n S
RG
AP
3 2
6.20
38
869
Cel
l com
mun
icat
ion
; Sig
nal t
rans
duct
ion
S
TE20
-like
ser
ine/
thre
onin
e-pr
otei
n ki
nase
S
LK
2 5.
08
1426
95
Cel
l com
mun
icat
ion
; Sig
nal t
rans
duct
ion
S
tress
-indu
ced-
phos
phop
rote
in 1
S
TIP
1 3
6.40
62
639
Cel
l com
mun
icat
ion
; Sig
nal t
rans
duct
ion
Stri
atin
ST
RN
2
5.12
86
132
Cel
l com
mun
icat
ion
; Sig
nal t
rans
duct
ion
S
uppr
esso
r of G
2 al
lele
of S
KP
1 ho
mol
og
SUG
T1
2 5.
07
4102
4 C
ell c
omm
unic
atio
n ; S
igna
l tra
nsdu
ctio
n
Tyro
sine
-pro
tein
pho
spha
tase
non
-rece
ptor
type
sub
stra
te 1
S
IRP
A
2 6.
29
5481
3 C
ell c
omm
unic
atio
n ; S
igna
l tra
nsdu
ctio
n
Vis
inin
-like
pro
tein
1
VS
NL1
2
5.01
22
142
Cel
l com
mun
icat
ion
; Sig
nal t
rans
duct
ion
S
eptin
Q
7KYV
2_H
UM
AN
4 6.
10
4415
8 C
ell c
ycle
S
eptin
-2
SE
PT2
2
6.15
41
487
Cel
l cyc
le
Sep
tin-4
S
EP
T4
2 5.
77
5509
8 C
ell c
ycle
A
lpha
-add
ucin
AD
D1
3 5.
60
8095
5 C
ell g
row
th a
nd/o
r mai
nten
ance
ac
tin g
amm
a AC
TG1
11
5.31
41
792
Cel
l gro
wth
and
/or m
aint
enan
ce
alph
a-ac
tinin
1 -
hum
an
ACTN
1 3
5.25
10
3057
C
ell g
row
th a
nd/o
r mai
nten
ance
A
lpha
-inte
rnex
in
INA
4
5.34
55
391
Cel
l gro
wth
and
/or m
aint
enan
ce
Ank
yrin
-2
AN
K2
3 5.
03
4303
44
Cel
l gro
wth
and
/or m
aint
enan
ce
Ban
d 4.
1-lik
e pr
otei
n 3
EP
B41
L3
7 5.
09
1206
78
Cel
l gro
wth
and
/or m
aint
enan
ce
Bas
emen
t mem
bran
e-sp
ecifi
c he
para
n su
lfate
pro
teog
lyca
n co
re p
rote
in [P
recu
rsor
] H
SP
G2
2 6.
06
4688
25
Cel
l gro
wth
and
/or m
aint
enan
ce
Bet
a-ad
duci
n AD
D2
2 5.
67
8085
4 C
ell g
row
th a
nd/o
r mai
nten
ance
B
eta-
spec
trin
2 is
ofor
m 2
.- H
omo
sapi
ens
(Hum
an).
SPTB
N1
24
5.39
27
4609
C
ell g
row
th a
nd/o
r mai
nten
ance
B
ystin
B
YSL
2
8.19
49
601
Cel
l gro
wth
and
/or m
aint
enan
ce
Cat
enin
-4 [F
ragm
ent]
Q6L
CG
8_H
UM
AN
2 9.
40
6800
9 C
ell g
row
th a
nd/o
r mai
nten
ance
C
dc42
effe
ctor
pro
tein
1
CD
C42
EP1
2 6.
64
4029
5 C
ell g
row
th a
nd/o
r mai
nten
ance
C
lath
rin h
eavy
cha
in 1
C
LTC
16
5.
48
1916
15
Cel
l gro
wth
and
/or m
aint
enan
ce
Cla
thrin
hea
vy c
hain
2
CLT
CL1
2
5.57
18
7030
C
ell g
row
th a
nd/o
r mai
nten
ance
C
LIP
1 pr
otei
n [F
ragm
ent]
CLI
P1
2 7.
20
7173
3 C
ell g
row
th a
nd/o
r mai
nten
ance
C
LIP
-ass
ocia
ting
prot
ein
1 C
LAS
P1
2 9.
14
1694
51
Cel
l gro
wth
and
/or m
aint
enan
ce
Cof
ilin-
1 C
FL1
2
8.22
18
502
Cel
l gro
wth
and
/or m
aint
enan
ce
Con
tact
in-1
C
NTN
1 2
5.62
11
3320
C
ell g
row
th a
nd/o
r mai
nten
ance
C
oron
in-1
A
CO
RO
1A
2 6.
25
5102
6 C
ell g
row
th a
nd/o
r mai
nten
ance
C
oron
in-2
B
CO
RO
2B
2 8.
39
5439
3 C
ell g
row
th a
nd/o
r mai
nten
ance
C
RM
P1
prot
ein
[Fra
gmen
t] C
RM
P1
3 8.
94
4374
6 C
ell g
row
th a
nd/o
r mai
nten
ance
D
esm
in
DE
S
2 5.
21
5353
6 C
ell g
row
th a
nd/o
r mai
nten
ance
D
ynac
tin s
ubun
it 2
DC
TN2
2 5.
10
4423
1 C
ell g
row
th a
nd/o
r mai
nten
ance
G
lial f
ibril
lary
aci
dic
prot
ein
GFA
P
64
5.40
49
880
Cel
l gro
wth
and
/or m
aint
enan
ce
GTP
ase,
IMA
P fa
mily
mem
ber 6
[Fra
gmen
t] M
AP
6 3
9.34
77
071
Cel
l gro
wth
and
/or m
aint
enan
ce
Hya
luro
nan
and
prot
eogl
ycan
link
pro
tein
2 p
recu
rsor
H
APLN
2 3
9.12
37
775
Cel
l gro
wth
and
/or m
aint
enan
ce
Inte
rnex
in n
euro
nal i
nter
med
iate
fila
men
t pro
tein
, alp
ha
INA
2
5.34
55
391
Cel
l gro
wth
and
/or m
aint
enan
ce
Kin
esin
-like
pro
tein
KIF
17
KIF
17
2 5.
38
1151
14
Cel
l gro
wth
and
/or m
aint
enan
ce
Kin
esin
-like
pro
tein
KIF
21A
K
IF21
A
7 6.
05
1871
79
Cel
l gro
wth
and
/or m
aint
enan
ce
Kin
esin
-like
pro
tein
KIF
2A
KIF
2A
2 6.
28
7995
5 C
ell g
row
th a
nd/o
r mai
nten
ance
La
min
-A/C
LM
NA
3 6.
57
7939
7 C
ell g
row
th a
nd/o
r mai
nten
ance
La
min
-B2
LMN
B2
6 5.
29
6768
9 C
ell g
row
th a
nd/o
r mai
nten
ance
M
icro
tubu
le-a
ssoc
iate
d pr
otei
n 1A
M
AP
1A
13
4.86
30
6482
C
ell g
row
th a
nd/o
r mai
nten
ance
M
icro
tubu
le-a
ssoc
iate
d pr
otei
n 1B
M
AP
1B
9 4.
73
2706
20
Cel
l gro
wth
and
/or m
aint
enan
ce
Mic
rotu
bule
-ass
ocia
ted
prot
ein
1S
MA
P1S
2
7.21
11
2437
C
ell g
row
th a
nd/o
r mai
nten
ance
M
icro
tubu
le-a
ssoc
iate
d pr
otei
n 2
MA
P2
7 4.
83
1995
39
Cel
l gro
wth
and
/or m
aint
enan
ce
Mic
rotu
bule
-ass
ocia
ted
prot
ein
tau
MAP
T 8
6.25
78
878
Cel
l gro
wth
and
/or m
aint
enan
ce
Moe
sin
MSN
2
6.08
67
820
Cel
l gro
wth
and
/or m
aint
enan
ce
Mut
S p
rote
in h
omol
og 5
M
SH5
2 5.
95
9287
5 C
ell g
row
th a
nd/o
r mai
nten
ance
M
yosi
n-Id
M
YO1D
2
9.44
11
6202
C
ell g
row
th a
nd/o
r mai
nten
ance
N
euro
fibro
min
-2
NF2
2
6.11
69
690
Cel
l gro
wth
and
/or m
aint
enan
ce
Neu
rofil
amen
t hea
vy p
olyp
eptid
e N
EFH
8
5.89
11
2480
C
ell g
row
th a
nd/o
r mai
nten
ance
N
euro
filam
ent t
riple
t L p
rote
in (6
8 kD
a ne
urof
ilam
ent p
rote
in) (
Neu
rofil
amen
t lig
ht p
olyp
eptid
e) (N
N
EFL
18
4.64
61
517
Cel
l gro
wth
and
/or m
aint
enan
ce
Neu
rofil
amen
t trip
let M
pro
tein
(160
kD
a ne
urof
ilam
ent p
rote
in) (
Neu
rofil
amen
t med
ium
pol
ypep
tide)
N
EFM
19
4.
90
1024
48
Cel
l gro
wth
and
/or m
aint
enan
ce
NS
FL1
cofa
ctor
p47
N
SFL
1C
2 4.
99
4057
3 C
ell g
row
th a
nd/o
r mai
nten
ance
O
uter
den
se fi
ber p
rote
in 1
O
DF1
2
8.46
28
366
Cel
l gro
wth
and
/or m
aint
enan
ce
Per
icen
trin
(Ken
drin
) PC
NT
2 5.
39
3780
81
Cel
l gro
wth
and
/or m
aint
enan
ce
Rho
GD
P-d
isso
ciat
ion
inhi
bito
r 1
ARH
GD
IA
5 5.
03
2320
7 C
ell g
row
th a
nd/o
r mai
nten
ance
S
arco
mer
ic tr
opom
yosi
n ka
ppa
TPM
1 3
4.65
32
650
Cel
l gro
wth
and
/or m
aint
enan
ce
Spe
ctrin
alp
ha c
hain
, bra
in (S
pect
rin, n
on-e
ryth
roid
alp
ha c
hain
) (A
lpha
-II s
pect
rin) (
Fodr
in a
lpha
) SP
TAN
1 28
5.
22
2845
39
Cel
l gro
wth
and
/or m
aint
enan
ce
Spe
ctrin
bet
a ch
ain,
bra
in 2
SP
TBN
2 4
5.79
27
1295
C
ell g
row
th a
nd/o
r mai
nten
ance
S
tath
min
1/o
ncop
rote
in 1
8 ST
MN
1 2
5.76
17
337
Cel
l gro
wth
and
/or m
aint
enan
ce ;
Sig
nal t
rans
duct
ion
Tr
opom
odul
in-2
TM
OD
2 2
5.21
39
595
Cel
l gro
wth
and
/or m
aint
enan
ce
Trop
omyo
sin
3 TP
M3
4 4.
81
2628
2 C
ell g
row
th a
nd/o
r mai
nten
ance
Tr
opom
yosi
n al
pha-
4 ch
ain
TPM
4 5
4.67
28
522
Cel
l gro
wth
and
/or m
aint
enan
ce
TUB
A1B
pro
tein
TU
BA
1B
7 4.
87
3721
8 C
ell g
row
th a
nd/o
r mai
nten
ance
Tu
bulin
alp
ha-1
A c
hain
TU
BA
1A
28
4.94
50
136
Cel
l gro
wth
and
/or m
aint
enan
ce
Tubu
lin a
lpha
-1C
cha
in
TUBA
1C
3 4.
96
4989
5 C
ell g
row
th a
nd/o
r mai
nten
ance
Tu
bulin
alp
ha-4
A c
hain
TU
BA
4A
5 4.
95
4992
4 C
ell g
row
th a
nd/o
r mai
nten
ance
Tu
bulin
bet
a-2B
cha
in
TUB
B2B
19
4.
78
4995
3 C
ell g
row
th a
nd/o
r mai
nten
ance
Tu
bulin
bet
a-4
chai
n TU
BB4
13
5.55
88
382
Cel
l gro
wth
and
/or m
aint
enan
ce
Tubu
lin p
olym
eriz
atio
n-pr
omot
ing
prot
ein
TPP
P
21
9.48
23
694
Cel
l gro
wth
and
/or m
aint
enan
ce
Tubu
lin p
olym
eriz
atio
n-pr
omot
ing
prot
ein
fam
ily m
embe
r 3
TPP
P3
2 9.
19
1898
5 C
ell g
row
th a
nd/o
r mai
nten
ance
U
NC
45 h
omol
og B
U
NC
45B
2 8.
03
1037
33
Cel
l gro
wth
and
/or m
aint
enan
ce
Vim
entin
V
IM
6 5.
06
5365
2 C
ell g
row
th a
nd/o
r mai
nten
ance
N
eure
xin-
1-al
pha
[Pre
curs
or]
NR
XN
1 2
5.61
16
1883
C
ell r
ecog
nitio
n
Ple
ctin
-1
PLE
C1
27
5.
73
5317
33
Cyt
oske
leta
l anc
horin
g
Sor
bin
and
SH
3 do
mai
n co
ntai
ning
1
SO
RB
S1
2 6.
40
1425
13
Cyt
oske
leto
n or
gani
zatio
n an
d bi
ogen
esis
; S
igna
l tra
nsdu
ctio
n
Erm
in
KIA
A11
89
2 4.
75
3278
3 C
ytos
kele
ton
orga
niza
tion
and
biog
enes
is; C
ell r
ecog
nitio
n S
eptin
D
KFZp
686F
1726
8 2
8.76
50
263
GTP
ase
activ
ity
Bet
a-de
fens
in 3
[Fra
gmen
t] D
EFB
103A
2
10
.08
5161
Im
mun
e re
spon
seC
ell a
dhes
ion
mol
ecul
e 3
[Pre
curs
or]
CAD
M3
2 5.
71
4330
0 Im
mun
e re
spon
se
Leuk
ocyt
e su
rface
ant
igen
CD
47 [P
recu
rsor
] C
D47
2
6.82
35
214
Imm
une
resp
onse
M
yelin
bas
ic p
rote
in
MB
P
32
9.79
33
117
Imm
une
resp
onse
; N
euro
gene
sis
2'
,3'-c
yclic
-nuc
leot
ide
3'-p
hosp
hodi
este
rase
C
NP
18
9.17
47
579
Met
abol
ism
; E
nerg
y pa
thw
ays
A
cyl-C
oA-b
indi
ng p
rote
in
DBI
2
6.12
10
044
Met
abol
ism
; E
nerg
y pa
thw
ays
A
lpha
eno
lase
E
NO
1 23
7.
01
4716
9 M
etab
olis
m ;
Ene
rgy
path
way
s
Alp
ha-a
min
oadi
pic
sem
iald
ehyd
e de
hydr
ogen
ase
ALD
H7A
1 2
6.44
55
366
Met
abol
ism
; E
nerg
y pa
thw
ays
A
MP
dea
min
ase
2 AM
PD2
2
6.46
10
0688
M
etab
olis
m ;
Ene
rgy
path
way
s
Asp
arta
te a
min
otra
nsfe
rase
, cyt
opla
smic
G
OT1
11
6.
53
4624
8 M
etab
olis
m ;
Ene
rgy
path
way
s
ATP
syn
thas
e su
buni
t alp
ha, m
itoch
ondr
ial
ATP
5A1
14
9.16
59
751
Met
abol
ism
; E
nerg
y pa
thw
ays
A
TP s
ynth
ase
subu
nit b
eta,
mito
chon
dria
l [P
recu
rsor
] A
TP5B
13
5.
26
5656
0 M
etab
olis
m ;
Ene
rgy
path
way
s A
TPas
e, H
+/K
+ ex
chan
ging
, bet
a po
lype
ptid
e A
TP4B
8
6.98
33
367
Met
abol
ism
; E
nerg
y pa
thw
ays
Bifu
nctio
nal m
ethy
lene
tetra
hydr
ofol
ate
dehy
drog
enas
e/cy
cloh
ydro
lase
, mito
chon
dria
l M
THFD
2 3
8.86
37
895
Met
abol
ism
; E
nerg
y pa
thw
ays
C
reat
ine
kina
se B
-type
C
KB
22
5.
34
4264
4 M
etab
olis
m ;
Ene
rgy
path
way
s
Cyt
ochr
ome
b-c1
com
plex
sub
unit
7 U
QC
RB
4 8.
73
1353
0 M
etab
olis
m ;
Ene
rgy
path
way
s
Cyt
ochr
ome
c ox
idas
e po
lype
ptid
e V
ic
CO
X6C
2
10.3
8 87
81
Met
abol
ism
; E
nerg
y pa
thw
ays
C
ytoc
hrom
e c
oxid
ase
subu
nit 5
A, m
itoch
ondr
ial
CO
X5A
2
6.30
16
774
Met
abol
ism
; E
nerg
y pa
thw
ays
C
ytoc
hrom
e c
oxid
ase
subu
nit 5
B, m
itoch
ondr
ial
CO
X5B
2
9.07
13
696
Met
abol
ism
; E
nerg
y pa
thw
ays
D
ihyd
ropy
rimid
inas
e-lik
e 3
DP
YSL3
15
6.
04
6197
9 M
etab
olis
m ;
Ene
rgy
path
way
s
Dip
hosp
hoin
osito
l pol
ypho
spha
te p
hosp
hohy
drol
ase
3 al
pha
NU
DT1
0 2
5.52
18
500
Met
abol
ism
; E
nerg
y pa
thw
ays
Dyn
ein
heav
y ch
ain,
cyt
osol
ic
DYN
C1H
1 2
6.01
53
2408
M
etab
olis
m ;
Ene
rgy
path
way
s Fa
tty a
cid
synt
hase
FA
SN
2 5.
99
2734
00
Met
abol
ism
; E
nerg
y pa
thw
ays
fru
ctos
e-bi
spho
spha
te a
ldol
ase
C -
hum
an
ALD
OC
17
6.
41
3945
6 M
etab
olis
m ;
Ene
rgy
path
way
s
Fum
arat
e hy
drat
ase,
mito
chon
dria
l [P
recu
rsor
] FH
2
8.85
54
637
Met
abol
ism
; E
nerg
y pa
thw
ays
G
amm
a-en
olas
e E
NO
2
5 4.
91
4726
9 M
etab
olis
m ;
Ene
rgy
path
way
s
Glu
cose
-6-p
hosp
hate
isom
eras
e G
PI
6 8.
42
6314
7 M
etab
olis
m ;
Ene
rgy
path
way
s
GLU
D2
prot
ein
GLU
D2
2 6.
72
2929
0 M
etab
olis
m ;
Ene
rgy
path
way
s gl
utam
ate
dehy
drog
enas
e 1
prec
urso
r G
LUD
1 3
7.66
61
398
Met
abol
ism
; E
nerg
y pa
thw
ays
G
luta
mat
e-am
mon
ia li
gase
(Glu
tam
ine
synt
heta
se) d
omai
n co
ntai
ning
1
GLU
LD1
4 5.
96
5727
8 M
etab
olis
m ;
Ene
rgy
path
way
s
Glu
tath
ione
S-tr
ansf
eras
e P
G
STP
1 4
5.43
23
356
Met
abol
ism
; E
nerg
y pa
thw
ays
G
lyce
rald
ehyd
e-3-
phos
phat
e de
hydr
ogen
ase
GAP
DH
29
8.
57
3605
3 M
etab
olis
m ;
Ene
rgy
path
way
s
Gly
coge
n ph
osph
oryl
ase,
bra
in fo
rm
PYG
B
2 6.
40
9669
6 M
etab
olis
m ;
Ene
rgy
path
way
s
Hex
okin
ase-
1 H
K1
6 6.
36
1024
86
Met
abol
ism
; E
nerg
y pa
thw
ays
Is
ocitr
ate
dehy
drog
enas
e [N
AD
P],
mito
chon
dria
l [P
recu
rsor
] ID
H2
5 8.
88
5090
9 M
etab
olis
m ;
Ene
rgy
path
way
s
Lact
oylg
luta
thio
ne ly
ase
GLO
1
2 5.
12
2077
8 M
etab
olis
m ;
Ene
rgy
path
way
s
Lano
ster
ol s
ynth
ase
LSS
2
6.16
83
309
Met
abol
ism
; E
nerg
y pa
thw
ays
M
alat
e de
hydr
ogen
ase
MD
H2
2
8.92
35
559
Met
abol
ism
; E
nerg
y pa
thw
ays
M
ethy
lmal
onat
e-se
mia
ldeh
yde
dehy
drog
enas
e [a
cyla
ting]
, mito
chon
dria
l [P
recu
rsor
] AL
DH
6A1
2 8.
72
5784
0 M
etab
olis
m ;
Ene
rgy
path
way
s
Mito
fusi
n-2
MFN
2 4
6.52
86
402
Met
abol
ism
; E
nerg
y pa
thw
ays
N
(G),N
(G)-
dim
ethy
larg
inin
e di
met
hyla
min
ohyd
rola
se 1
D
DAH
1 4
5.53
31
122
Met
abol
ism
; E
nerg
y pa
thw
ays
N
AD
H d
ehyd
roge
nase
(Ubi
quin
one)
1 b
eta
subc
ompl
ex, 6
, 17k
Da
ND
UFB
6 2
9.52
13
716
Met
abol
ism
; Ene
rgy
path
way
s N
AD
H d
ehyd
roge
nase
[ubi
quin
one]
1 b
eta
subc
ompl
ex s
ubun
it 5,
mito
chon
dria
N
DU
FB5
2 9.
62
2175
0 M
etab
olis
m ;
Ene
rgy
path
way
s
NA
DH
deh
ydro
gena
se [u
biqu
inon
e] ir
on-s
ulfu
r pro
tein
5
ND
UFS
5 4
9.27
12
518
Met
abol
ism
; E
nerg
y pa
thw
ays
N
AD
H-u
biqu
inon
e ox
idor
educ
tase
75
kDa
subu
nit,
mito
chon
dria
l N
DU
FS1
3 5.
89
7946
8 M
etab
olis
m ;
Ene
rgy
path
way
s
ND
UFV
2 pr
otei
n N
DU
FV2
2 8.
22
2734
9 M
etab
olis
m ;
Ene
rgy
path
way
s
Pal
mito
yl-p
rote
in th
ioes
tera
se 1
[Fra
gmen
t] P
PT1
2
6.94
12
131
Met
abol
ism
; E
nerg
y pa
thw
ays
P
erox
iredo
xin-
1 PR
DX
1 8
8.27
22
110
Met
abol
ism
; E
nerg
y pa
thw
ays
P
erox
iredo
xin-
2 PR
DX
2
2 5.
66
2189
2 M
etab
olis
m ;
Ene
rgy
path
way
s
Pho
spha
tase
and
act
in re
gula
tor 1
PH
ACTR
1 2
6.51
66
308
Met
abol
ism
; E
nerg
y pa
thw
ays
P
hosp
hogl
ycer
ate
kina
se 1
P
GK
1 5
8.30
44
615
Met
abol
ism
; E
nerg
y pa
thw
ays
Pho
spho
glyc
erat
e M
utas
e 1
PG
AM
1 3
6.67
28
804
Met
abol
ism
; E
nerg
y pa
thw
ays
P
hosp
hose
rine
amin
otra
nsfe
rase
P
SA
T1
4 7.
56
4042
3 M
etab
olis
m ;
Ene
rgy
path
way
s
Pro
pion
yl-C
oA c
arbo
xyla
se a
lpha
sub
uni
PCC
A 2
7.24
80
059
Met
abol
ism
; E
nerg
y pa
thw
ays
P
terin
-4-a
lpha
-car
bino
lam
ine
dehy
drat
ase
2 PC
BD2
6 6.
97
1176
1 M
etab
olis
m ;
Ene
rgy
path
way
s
Pyr
uvat
e de
hydr
ogen
ase
E1
com
pone
nt s
ubun
it al
pha,
som
atic
form
, mito
chon
dria
l PD
HA1
6
8.35
43
296
Met
abol
ism
; E
nerg
y pa
thw
ays
P
yruv
ate
kina
se is
ozym
es M
1/M
2 P
KM
2 7
7.96
57
937
Met
abol
ism
; E
nerg
y pa
thw
ays
S
eryl
-tRN
A s
ynth
etas
e, c
ytop
lasm
ic
SA
RS
2
6.05
58
777
Met
abol
ism
; E
nerg
y pa
thw
ays
S
TIP
1 ho
mol
ogy
and
U b
ox-c
onta
inin
g pr
otei
n 1
STU
B1
2 5.
61
3485
6 M
etab
olis
m ;
Ene
rgy
path
way
s
Sup
erox
ide
dism
utas
e [C
u-Zn
] S
OD
1 2
5.70
15
936
Met
abol
ism
; E
nerg
y pa
thw
ays
Syn
apto
jani
n-1
SYN
J1
3
7.13
17
3346
M
etab
olis
mTh
iore
doxi
n-lik
e pr
otei
n 1
TXN
L1
2 4.
84
3225
1 M
etab
olis
m ;
Ene
rgy
path
way
s
Tran
sald
olas
e TA
LDO
1 2
6.36
37
540
Met
abol
ism
; E
nerg
y pa
thw
ays
Tran
sitio
nal e
ndop
lasm
ic re
ticul
um A
TPas
e V
CP
3
5.14
89
322
Met
abol
ism
; E
nerg
y pa
thw
ays
Tran
sket
olas
e TK
T 3
7.58
67
878
Met
abol
ism
; E
nerg
y pa
thw
ays
Ty
rosy
l-tR
NA
syn
thet
ase,
cyt
opla
smic
YA
RS
2
6.61
59
143
Met
abol
ism
; E
nerg
y pa
thw
ays
V
acuo
lar A
TP s
ynth
ase
cata
lytic
sub
unit
A
ATP
6V1A
3
5.35
68
304
Met
abol
ism
; E
nerg
y pa
thw
ays
Ves
icle
-fusi
ng A
TPas
e N
SF
4 6.
52
8256
0 M
etab
olis
m ;
Ene
rgy
path
way
s
Syn
taxi
n-bi
ndin
g pr
otei
n 1
STX
BP1
20
6.50
67
569
Neu
rotra
nsm
itter
tran
spor
tM
u-cr
ysta
llin
hom
olog
C
RYM
2
5.06
33
776
Osm
oreg
ulat
ion
; Hor
mon
e m
etab
olis
m
Cal
nexi
n [P
recu
rsor
] C
ANX
4
4.47
67
568
Pro
tein
fold
ing
End
opla
smic
retic
ulum
pro
tein
ER
p29
[Pre
curs
or]
ER
P29
2
6.77
28
993
Pro
tein
fold
ing
H
eat s
hock
70
kDa
prot
ein
12A
H
SP
A12
A
2
6.32
74
978
Pro
tein
fold
ing
40S
ribo
som
al p
rote
in S
13
RP
S13
2
10
.53
1722
2 P
rote
in m
etab
olis
m40
S ri
boso
mal
pro
tein
S18
R
PS
18
2
10.9
9 17
719
Pro
tein
met
abol
ism
40S
ribo
som
al p
rote
in S
7 R
PS
7 2
10
.09
2212
7 P
rote
in m
etab
olis
m60
S ri
boso
mal
pro
tein
L27
R
PL2
7 2
10
.56
1579
8 P
rote
in m
etab
olis
mA
lpha
-cry
stal
lin B
cha
in
CR
YAB
6
6.76
20
159
Pro
tein
met
abol
ism
Cal
pain
-1 c
atal
ytic
sub
unit
CAP
N1
2
5.49
81
890
Pro
tein
met
abol
ism
Cat
heps
in B
C
TSB
2
5.88
37
822
Pro
tein
met
abol
ism
CD
C37
pro
tein
C
DC
37
2 5.
17
4445
3 P
rote
in m
etab
olis
m
Cha
pero
nin
cont
aini
ng T
CP
1, s
ubun
it 3
CC
T3
2 6.
46
5797
2 P
rote
in m
etab
olis
m
Cul
lin-3
C
UL3
4
8.68
88
930
Pro
tein
met
abol
ism
D
naJ
hom
olog
sub
fam
ily B
mem
ber 1
D
NAJ
B1
2
8.74
38
044
Pro
tein
met
abol
ism
Dna
J ho
mol
og s
ubfa
mily
B m
embe
r 2
DN
AJB
2
2 5.
69
3558
0 P
rote
in m
etab
olis
m
EE
F2K
pro
tein
E
EF2
K
2
5.19
82
191
Pro
tein
met
abol
ism
endo
plas
min
pre
curs
or -
hum
an
HS
P90
B1
2
4.76
92
469
Pro
tein
met
abol
ism
Euk
aryo
tic in
itiat
ion
fact
or 4
A-I
EIF
4A1
3
5.32
46
154
Pro
tein
met
abol
ism
Euk
aryo
tic tr
ansl
atio
n in
itiat
ion
fact
or 2
sub
unit
1 E
IF2S
1 2
5.02
36
112
Pro
tein
met
abol
ism
E
ukar
yotic
tran
slat
ion
initi
atio
n fa
ctor
4B
E
IF4B
2
5.55
69
166
Pro
tein
met
abol
ism
Fi
brin
ogen
alp
ha c
hain
pre
curs
or
FGA
2
5.
70
9497
3 P
rote
in m
etab
olis
mH
BS
1-lik
e pr
otei
n H
BS
1L
2
6.17
75
473
Pro
tein
met
abol
ism
Hea
t sho
ck 1
05kD
a/11
0kD
a pr
otei
n 1
HSP
H1
4
5.29
92
255
Pro
tein
met
abol
ism
Hea
t sho
ck 7
0 kD
a pr
otei
n 4L
H
SP
A4L
2
5.63
94
486
Pro
tein
met
abol
ism
H
eat s
hock
70k
Da
prot
ein
1A
HS
PA
1A
2
5.35
70
038
Pro
tein
Met
abol
ism
Hea
t sho
ck c
ogna
te 7
1 kD
a pr
otei
n H
SP
A8
5
5.37
70
898
Pro
tein
met
abol
ism
Hea
t sho
ck-re
late
d 70
kD
a pr
otei
n 2
HS
PA
2 18
5.
56
7002
1 P
rote
in m
etab
olis
m
HS
P90
AA
1 pr
otei
n [F
ragm
ent]
HS
P90
AA
1 2
5.08
73
827
Pro
tein
met
abol
ism
H
SP
A8
prot
ein
[Fra
gmen
t] H
SP
A8
7 5.
36
6467
3 P
rote
in m
etab
olis
m
HS
PA
9 pr
otei
n [F
ragm
ent]
HS
PA
9 3
6.
04
7385
4 P
rote
in m
etab
olis
mP
heny
lala
nyl-t
RN
A s
ynth
etas
e al
pha
chai
n FA
RSA
2
7.31
57
564
Pro
tein
met
abol
ism
P
rote
asom
e su
buni
t bet
a ty
pe
PS
MB
4 5
5.70
29
190
Pro
tein
met
abol
ism
P
rote
in d
isul
fide-
isom
eras
e A
3 [P
recu
rsor
] P
DIA
3 4
5.
98
5678
2 P
rote
in M
etab
olis
mP
urom
ycin
-sen
sitiv
e am
inop
eptid
ase
NP
EP
PS
2
5.49
10
3276
P
rote
in m
etab
olis
m
Put
ativ
e ty
rosi
ne-p
rote
in p
hosp
hata
se a
uxili
n D
NAJ
C6
2 6.
82
9999
7 P
rote
in m
etab
olis
m
RP
L26
prot
ein
RP
L26
4
10.5
5 17
244
Pro
tein
met
abol
ism
S-p
hase
kin
ase-
asso
ciat
ed p
rote
in 1
A
SK
P1A
2
4.40
18
658
Pro
tein
met
abol
ism
; R
egul
atio
n of
cel
l cyc
le ;
Chr
omos
ome
segr
egat
ion
Spl
icin
g fa
ctor
, arg
inin
e/se
rine-
rich
1 SF
RS1
2
10
.37
2774
5 P
rote
in m
etab
olis
mS
UM
O-a
ctiv
atin
g en
zym
e su
buni
t 2
SA
E2
2
5.15
71
224
Pro
tein
met
abol
ism
T-
com
plex
pro
tein
1 s
ubun
it al
pha
CC
T1
2
5.80
60
344
Pro
tein
met
abol
ism
T-co
mpl
ex p
rote
in 1
sub
unit
thet
a C
CT8
5
5.
42
5962
1 P
rote
in m
etab
olis
mTu
bulin
-spe
cific
cha
pero
ne A
TB
CA
2
5.25
12
855
Pro
tein
met
abol
ism
Tubu
lin-s
peci
fic c
hape
rone
E
TBC
E 2
6.32
59
346
Pro
tein
met
abol
ism
U
biqu
itin-
conj
ugat
ing
enzy
me
E2
D4
UBE
2D4
10
6.
88
1664
9 P
rote
in m
etab
olis
mU
ncha
ract
eriz
ed p
rote
in K
IAA
1279
K
IAA
1279
2
5.34
71
814
Reg
ulat
ion
of c
ell c
ycle
; M
itoch
ondr
ial t
rans
port
; Neu
roge
nesi
s ; P
rote
in fo
ldin
g C
SD
E1
prot
ein
[Fra
gmen
t] C
SDE1
2
5.31
30
108
Reg
ulat
ion
of g
ene
expr
essi
on, e
pige
netic
C
ullin
-ass
ocia
ted
NE
DD
8-di
ssoc
iate
d pr
otei
n 1
CAN
D1
2
5.52
13
6376
R
egul
atio
n of
nuc
leob
ase,
nuc
leos
ide,
nuc
leot
ide
and
nucl
eic
acid
met
abol
ism
D
NA
-(ap
urin
ic o
r apy
rimid
inic
site
) lya
se
AP
EX1
2 8.
33
3555
5 R
egul
atio
n of
nuc
leob
ase,
nuc
leos
ide,
nuc
leot
ide
and
nucl
eic
acid
met
abol
ism
Fa
r ups
tream
ele
men
t-bin
ding
pro
tein
1
FUB
P1
2
7.18
67
560
Reg
ulat
ion
of n
ucle
obas
e, n
ucle
osid
e, n
ucle
otid
e an
d nu
clei
c ac
id m
etab
olis
m
Het
eroc
hrom
atin
pro
tein
1, b
indi
ng p
rote
in 3
H
P1B
P3
2
9.69
61
207
Reg
ulat
ion
of n
ucle
obas
e, n
ucle
osid
e, n
ucle
otid
e an
d nu
clei
c ac
id m
etab
olis
m
Het
erog
eneo
us n
ucle
ar ri
bonu
cleo
prot
ein
A0
HN
RPA
0 2
9.34
30
841
Reg
ulat
ion
of n
ucle
obas
e, n
ucle
osid
e, n
ucle
otid
e an
d nu
clei
c ac
id m
etab
olis
m
Het
erog
eneo
us n
ucle
ar ri
bonu
cleo
prot
ein
A1
HN
RPA
1 2
9.26
38
846
Reg
ulat
ion
of n
ucle
obas
e, n
ucle
osid
e, n
ucle
otid
e an
d nu
clei
c ac
id m
etab
olis
m
Het
erog
eneo
us n
ucle
ar ri
bonu
cleo
prot
ein
H3
HN
RPH
3 2
6.37
36
926
Reg
ulat
ion
of n
ucle
obas
e, n
ucle
osid
e, n
ucle
otid
e an
d nu
clei
c ac
id m
etab
olis
m
Het
erog
eneo
us n
ucle
ar ri
bonu
cleo
prot
ein
K
HN
RPK
3
5.46
47
557
Reg
ulat
ion
of n
ucle
obas
e, n
ucle
osid
e, n
ucle
otid
e an
d nu
clei
c ac
id m
etab
olis
m
Het
erog
eneo
us n
ucle
ar ri
bonu
cleo
prot
ein
U [F
ragm
ent]
HN
RPU
5
8.06
79
844
Reg
ulat
ion
of n
ucle
obas
e, n
ucle
osid
e, n
ucle
otid
e an
d nu
clei
c ac
id m
etab
olis
m
His
tone
H2A
type
1-E
H
IST1
H2A
E
2 11
.05
1413
5 R
egul
atio
n of
nuc
leob
ase,
nuc
leos
ide,
nuc
leot
ide
and
nucl
eic
acid
met
abol
ism
H
isto
ne H
3/b
HIS
T1H
3B
24
11.1
3 15
404
Reg
ulat
ion
of n
ucle
obas
e, n
ucle
osid
e, n
ucle
otid
e an
d nu
clei
c ac
id m
etab
olis
m
His
tone
H4
HIS
T1H
4A
5 11
.36
1136
7 R
egul
atio
n of
nuc
leob
ase,
nuc
leos
ide,
nuc
leot
ide
and
nucl
eic
acid
met
abol
ism
LI
M d
omai
n 7
LMO
7 2
7.90
15
3670
R
egul
atio
n of
nuc
leob
ase,
nuc
leos
ide,
nuc
leot
ide
and
nucl
eic
acid
met
abol
ism
N
on-P
OU
dom
ain-
cont
aini
ng o
ctam
er-b
indi
ng p
rote
in
NO
NO
2
9.01
54
232
Reg
ulat
ion
of n
ucle
obas
e, n
ucle
osid
e, n
ucle
otid
e an
d nu
clei
c ac
id m
etab
olis
m
Opt
ineu
rin
OPT
N
2 5.
12
6592
2 R
egul
atio
n of
nuc
leob
ase,
nuc
leos
ide,
nuc
leot
ide
and
nucl
eic
acid
met
abol
ism
P
HD
fing
er p
rote
in 3
PH
F3
3 6.
52
2294
81
Reg
ulat
ion
of n
ucle
obas
e, n
ucle
osid
e, n
ucle
otid
e an
d nu
clei
c ac
id m
etab
olis
m
Pro
hibi
tin-2
P
HB
2 2
9.83
33
296
Reg
ulat
ion
of n
ucle
obas
e, n
ucle
osid
e, n
ucle
otid
e an
d nu
clei
c ac
id m
etab
olis
m
Pro
tein
bas
soon
BS
N
2 7.
28
4164
99
Reg
ulat
ion
of n
ucle
obas
e, n
ucle
osid
e, n
ucle
otid
e an
d nu
clei
c ac
id m
etab
olis
m
Pro
tein
DJ-
1 P
AR
K7
5 6.
33
1989
1 R
egul
atio
n of
nuc
leob
ase,
nuc
leos
ide,
nuc
leot
ide
and
nucl
eic
acid
met
abol
ism
P
utat
ive
hom
eodo
mai
n tra
nscr
iptio
n fa
ctor
1 [F
ragm
ent]
PHTF
1 2
9.99
12
332
Reg
ulat
ion
of n
ucle
obas
e, n
ucle
osid
e, n
ucle
otid
e an
d nu
clei
c ac
id m
etab
olis
m
Rib
onuc
leas
e in
hibi
tor
RN
H1
2 4.
71
4997
3 R
egul
atio
n of
nuc
leob
ase,
nuc
leos
ide,
nuc
leot
ide
and
nucl
eic
acid
met
abol
ism
R
ibos
omal
pro
tein
S27
R
PS
27
2 6.
71
7356
R
egul
atio
n of
nuc
leob
ase,
nuc
leos
ide,
nuc
leot
ide
and
nucl
eic
acid
met
abol
ism
TF
AM
pro
tein
[Fra
gmen
t] TF
AM
2 9.
74
2908
3 R
egul
atio
n of
nuc
leob
ase,
nuc
leos
ide,
nuc
leot
ide
and
nucl
eic
acid
met
abol
ism
Tr
ansc
riptio
nal a
ctiv
ator
pro
tein
Pur
-alp
ha
PUR
A 2
6.07
34
911
Reg
ulat
ion
of n
ucle
obas
e, n
ucle
osid
e, n
ucle
otid
e an
d nu
clei
c ac
id m
etab
olis
m
Tran
scrip
tiona
l rep
ress
or p
66 a
lpha
G
ATA
D2A
2
9.95
68
063
Reg
ulat
ion
of n
ucle
obas
e, n
ucle
osid
e, n
ucle
otid
e an
d nu
clei
c ac
id m
etab
olis
m
TSC
22 d
omai
n fa
mily
pro
tein
4
TSC
22D
4 2
6.69
41
026
Reg
ulat
ion
of n
ucle
obas
e, n
ucle
osid
e, n
ucle
otid
e an
d nu
clei
c ac
id m
etab
olis
m
U6
snR
NA
-ass
ocia
ted
Sm
-like
pro
tein
LS
m3
LSM
3 2
4.58
11
845
Reg
ulat
ion
of n
ucle
obas
e, n
ucle
osid
e, n
ucle
otid
e an
d nu
clei
c ac
id m
etab
olis
m
Cas
ein
kina
se II
sub
unit
alph
a C
SN
K2A
1 2
7.29
45
144
Sig
nal t
rans
duct
ion
; Pro
tein
mod
ifica
tion
C
-term
inal
bin
ding
pro
tein
2
CTB
P2
2 6.
50
5610
2 S
igna
l tra
nsdu
ctio
n ; C
ell c
omm
unic
atio
n
Neu
rona
l cel
l adh
esio
n m
olec
ule
[Pre
curs
or]
NR
CAM
2
5.45
14
3894
S
igna
l tra
nsdu
ctio
n
PTK
2B p
rote
in ty
rosi
ne k
inas
e 2
beta
P
TK2B
2
5.91
11
5907
S
igna
l tra
nsdu
ctio
n
AP
1 su
buni
t gam
ma-
bind
ing
prot
ein
1 A
P1G
BP
1 2
4.90
14
0654
Tr
ansp
ort
apol
ipop
rote
in E
pre
curs
or
AP
OE
2
5.
65
3615
4 Tr
ansp
ort
ATP
ase,
H+
trans
porti
ng, l
ysos
omal
56/
58kD
a, V
1 su
buni
t B1
ATP
6V1B
1
2
5.44
56
833
Tran
spor
tA
TPas
e, N
a+/K
+ tra
nspo
rting
, alp
ha 1
pol
ypep
tide
[Fra
gmen
t] A
TP1A
1 4
8.
48
1817
2 Tr
ansp
ort
Ca2
+-tra
nspo
rting
ATP
ase
(EC
3.6
.3.8
) 2, l
ong
splic
e fo
rm -
hum
an
ATP
2B2
5
5.66
13
6876
Tr
ansp
ort
Cal
cium
-act
ivat
ed p
otas
sium
cha
nnel
sub
unit
alph
a-1
KCN
MA1
2
6.
66
1375
60
Tran
spor
tC
ayta
xin
ATC
AY
2
4.54
42
120
Tran
spor
t
Cha
rged
mul
tives
icul
ar b
ody
prot
ein
5 C
HM
P5
2
4.68
24
571
Tran
spor
tC
oato
mer
sub
unit
alph
a C
OP
A
2
7.70
13
8332
Tr
ansp
ort
Ear
ly e
ndos
ome
antig
en 1
E
EA
1 2
5.
53
1624
66
Tran
spor
tE
lect
roge
nic
sodi
um b
icar
bona
te c
otra
nspo
rter 1
S
LC4A
4 2
6.
35
1214
61
Tran
spor
tG
DP
dis
soci
atio
n in
hibi
tor 2
[Fra
gmen
t] G
DI2
4
8.
98
1778
3 Tr
ansp
ort
Hem
oglo
bin
subu
nit b
eta
HB
B
13
6.
74
1599
8 Tr
ansp
ort
Impo
rtin
subu
nit b
eta-
1 K
PN
B1
2
4.68
97
170
Tran
spor
tP
lasm
a m
embr
ane
calc
ium
-tran
spor
ting
ATP
ase
1 A
TP2B
1 2
5.
73
1387
55
Tran
spor
tP
rote
in tr
ansp
ort p
rote
in S
ec31
A
SE
C31
A
2
6.43
13
3015
Tr
ansp
ort
Put
ativ
e un
char
acte
rized
pro
tein
DP
P6
[Fra
gmen
t] D
PP
6
2
6.11
64
982
Tran
spor
tR
abph
ilin-
3A
RPH
3A
4
8.62
76
872
Tran
spor
tR
egul
atin
g sy
napt
ic m
embr
ane
exoc
ytos
is p
rote
in 1
R
IMS1
2
9.
68
1890
73
Tran
spor
tR
etin
alde
hyde
-bin
ding
pro
tein
1
RLB
P1
2
4.98
36
474
Tran
spor
tS
arco
plas
mic
/end
opla
smic
retic
ulum
cal
cium
ATP
ase
2 A
TP2A
2 4
5.
23
1147
57
Tran
spor
tS
erum
alb
umin
A
LB
4
5.92
69
367
Tran
spor
tS
ider
ofle
xin-
1 S
FXN
1 5
9.
22
3561
9 Tr
ansp
ort
Sod
ium
/pot
assi
um-tr
ansp
ortin
g A
TPas
e su
buni
t alp
ha-3
A
TP1A
3 4
5.
22
1117
49
Tran
spor
tS
olut
e ca
rrie
r fam
ily 1
2 m
embe
r 5
SLC
12A
5 2
5.
91
1235
11
Tran
spor
tS
ynap
sin-
1 S
YN1
8
9.84
74
111
Tran
spor
tS
ynta
bulin
S
YBU
2
5.
87
7238
8 Tr
ansp
ort
Vac
uola
r ATP
syn
thas
e su
buni
t d 1
A
TP6V
0D1
2
4.89
40
329
Tran
spor
tV
esic
le-a
ssoc
iate
d m
embr
ane
prot
ein
2 (S
ynap
tobr
evin
2)
VA
MP
2 11
7.84
12
649
Tran
spor
tA
nkyr
in re
peat
and
MY
ND
dom
ain-
cont
aini
ng p
rote
in 2
AN
KMY2
4
5.88
49
299
Bio
logi
cal_
proc
ess
unkn
own
C
DN
A F
LJ16
308
fis, c
lone
PU
AE
N20
0633
5 Q
6ZN
96_H
UM
AN
2
8.84
63
671
Bio
logi
cal_
proc
ess
unkn
own
CD
NA
FLJ
2655
4 fis
, clo
ne L
NF0
1773
, hig
hly
sim
ilar t
o G
alac
toki
nase
Q
6ZP3
7_H
UM
AN
2
6.81
42
952
Bio
logi
cal_
proc
ess
unkn
own
CD
NA
FLJ
3410
6 fis
, clo
ne F
CB
BF3
0080
73, h
ighl
y si
mila
r to
SP
LIC
ING
FA
CTO
R, A
RG
ININ
E/S
ER
INE
-RIC
H 7
Q
8NB8
0_H
UM
AN
2
9.96
15
862
Bio
logi
cal_
proc
ess
unkn
own
CD
NA
FLJ
3699
8 fis
, clo
ne B
RA
CE
2007
295,
hig
hly
sim
ilar t
o A
LPH
A-A
DA
PTI
N A
Q
8N9K
4_H
UM
AN
2
5.72
52
032
Bio
logi
cal_
proc
ess
unkn
own
CD
NA
FLJ
4473
1 fis
, clo
ne B
RA
CE
3025
719,
hig
hly
sim
ilar t
o H
omo
sapi
ens
ring
finge
r pro
tein
22
Q6Z
TE7_
HU
MAN
2
9.
40
6227
7 B
iolo
gica
l_pr
oces
s un
know
nC
DN
A F
LJ46
514
fis, c
lone
TH
YM
U30
3279
8, h
ighl
y si
mila
r to
Foca
l adh
esio
n ki
nase
2
Q6Z
RA8
_HU
MAN
2
5.
47
6803
2 B
iolo
gica
l_pr
oces
s un
know
nC
entro
som
al p
rote
in C
ep29
0 C
EP
290
2
5.75
29
0386
B
iolo
gica
l_pr
oces
s un
know
nC
lone
CD
AB
P01
07 m
RN
A s
eque
nce
Q9H
4N1_
HU
MAN
2
5.
22
4566
5 B
iolo
gica
l_pr
oces
s un
know
nC
oile
d-co
il do
mai
n-co
ntai
ning
pro
tein
124
C
CD
C12
4 2
9.54
25
835
Bio
logi
cal_
proc
ess
unkn
own
C
oile
d-co
il-he
lix-c
oile
d-co
il-he
lix d
omai
n-co
ntai
ning
pro
tein
3
CH
CH
D3
7 8.
48
2615
2 B
iolo
gica
l_pr
oces
s un
know
n
Coi
led-
coil-
helix
-coi
led-
coil-
helix
dom
ain-
cont
aini
ng p
rote
in 6
C
HC
HD
6 2
9.
01
2645
8 B
iolo
gica
l_pr
oces
s un
know
nC
orta
ctin
-bin
ding
pro
tein
2
CTT
NBP
2 2
8.
23
1810
51
Bio
logi
cal_
proc
ess
unkn
own
DJ3
66N
23.2
(Put
ativ
e C
. ele
gans
UN
C-9
3 (P
rote
in 1
, C46
F11.
1)
O62
493
3
9.59
27
457
Bio
logi
cal_
proc
ess
unkn
own
Dna
J ho
mol
og s
ubfa
mily
C m
embe
r 11
DN
AJC
11
2 8.
54
6327
8 B
iolo
gica
l_pr
oces
s un
know
n
Dol
ichy
l-dip
hosp
hool
igos
acch
arid
e--p
rote
in g
lyco
syltr
ansf
eras
e su
buni
t STT
3B
STT3
B 2
9.
04
9367
4 B
iolo
gica
l_pr
oces
s un
know
nE
F-ha
nd d
omai
n-co
ntai
ning
pro
tein
2
EFH
D2
5
5.15
26
697
Bio
logi
cal_
proc
ess
unkn
own
ELM
O d
omai
n-co
ntai
ning
pro
tein
1
ELM
OD
1 2
8.78
39
052
Bio
logi
cal_
proc
ess
unkn
own
FL
J001
28 p
rote
in [F
ragm
ent]
FLJ0
0128
2
6.
00
1676
73
Bio
logi
cal_
proc
ess
unkn
own
Form
in-li
ke p
rote
in 2
FM
NL2
2
6.98
12
3400
B
iolo
gica
l_pr
oces
s un
know
n
Full-
leng
th c
DN
A 5
-PR
IME
end
of c
lone
CS
0DA
002Y
L09
of N
euro
blas
tom
a of
Hom
o sa
pien
s [F
ragm
ent]
Q86
TR5_
HU
MAN
2
8.
55
8963
B
iolo
gica
l_pr
oces
s un
know
nH
eme-
bind
ing
prot
ein
1 H
EB
P1
3 5.
71
2109
7 B
iolo
gica
l_pr
oces
s un
know
n
HIV
-1 R
ev-b
indi
ng p
rote
in-li
ke p
rote
in
HR
BL
2 9.
28
4896
3 B
iolo
gica
l_pr
oces
s un
know
n
HN
RP
A2B
1 pr
otei
n Q
9BW
A9_H
UM
AN
4
4.79
28
412
Bio
logi
cal_
proc
ess
unkn
own
Hyp
othe
tical
pro
tein
MG
C29
649.
- Hom
o sa
pien
s (H
uman
). TT
C9C
2
9.
02
2001
3 B
iolo
gica
l_pr
oces
s un
know
n
L1 c
ell a
dhes
ion
mol
ecul
e [F
ragm
ent]
L1C
AM
2
5.84
13
9772
B
iolo
gica
l_pr
oces
s un
know
n
LanC
lant
ibio
tic s
ynth
etas
e co
mpo
nent
C-li
ke 2
LA
NC
L2
2
7.18
50
850
Bio
logi
cal_
proc
ess
unkn
own
Mic
rotu
bule
-ass
ocia
ted
prot
eins
1A
/1B
ligh
t cha
in 3
B [P
recu
rsor
] M
AP
1LC
3B
4
8.89
14
688
Bio
logi
cal_
proc
ess
unkn
own
N-a
cety
late
d-al
pha-
linke
d ac
idic
dip
eptid
ase-
like
prot
ein
NA
ALA
DL1
3
5.28
80
622
Bio
logi
cal_
proc
ess
unkn
own
N
ovel
pro
tein
sim
ilar t
o be
ta-tu
bulin
4Q
[Fra
gmen
t] R
P11
-631
M21
.2
10
4.
95
4872
6 B
iolo
gica
l_pr
oces
s un
know
nN
SP
3 or
NS
34
Rot
aviru
s ge
ne-7
2
5.
32
3621
2 B
iolo
gica
l_pr
oces
s un
know
nN
UC
KS
pro
tein
N
UC
KS
2
4.75
18
747
Bio
logi
cal_
proc
ess
unkn
own
Nud
C d
omai
n-co
ntai
ning
pro
tein
3
NU
DC
D3
2 5.
16
4082
2 B
iolo
gica
l_pr
oces
s un
know
n
OTT
HU
MP
0000
0017
090
[Fra
gmen
t] R
P11
-632
C17
_A.1
-001
2
11
.00
1871
2 B
iolo
gica
l_pr
oces
s un
know
nO
XC
T pr
otei
n O
XC
T 4
7.
13
5619
2 B
iolo
gica
l_pr
oces
s un
know
nO
xogl
utar
ate
dehy
drog
enas
e-lik
e O
GD
HL
2
6.23
11
4496
B
iolo
gica
l_pr
oces
s un
know
np1
30C
as-a
ssoc
iate
d pr
otei
n P
140
2
9.
32
1124
66
Bio
logi
cal_
proc
ess
unkn
own
P60
, 60-
kDa
heat
sho
ck p
rote
in, H
SP
60 [F
ragm
ent]
Q9U
CR
6_H
UM
AN
7
4.58
29
91
Bio
logi
cal_
proc
ess
unkn
own
Par
alem
min
PA
LM
3
4.94
42
076
Bio
logi
cal_
proc
ess
unkn
own
Pep
tidyl
prol
yl is
omer
ase
dom
ain
and
WD
repe
at-c
onta
inin
g pr
otei
n 1
PPW
D1
6
6.70
73
575
Bio
logi
cal_
proc
ess
unkn
own
Pro
tein
RU
FY3
RU
FY3
2
5.36
52
965
Bio
logi
cal_
proc
ess
unkn
own
P
urin
e-ric
h el
emen
t bin
ding
pro
tein
A
Q5U
0P9_
HU
MAN
2
6.
28
3491
1 B
iolo
gica
l_pr
oces
s un
know
nP
utat
ive
G-p
rote
in c
oupl
ed re
cept
or
GPC
R
2
9.14
23
857
Bio
logi
cal_
proc
ess
unkn
own
Put
ativ
e un
char
acte
rized
pro
tein
JE
0193
3
5.
32
1261
8 B
iolo
gica
l_pr
oces
s un
know
nP
utat
ive
unch
arac
teriz
ed p
rote
in
CJE
0194
2
9.
03
2315
9 B
iolo
gica
l_pr
oces
s un
know
nP
utat
ive
unch
arac
teriz
ed p
rote
in [F
ragm
ent]
Q96
BE0_
HU
MAN
5
4.
80
2936
1 B
iolo
gica
l_pr
oces
s un
know
nP
utat
ive
unch
arac
teriz
ed p
rote
in [F
ragm
ent]
Q6P
G47
_HU
MAN
2
9.
05
3697
7 B
iolo
gica
l_pr
oces
s un
know
nP
utat
ive
unch
arac
teriz
ed p
rote
in D
KFZ
p451
F171
1 [F
ragm
ent]
DKF
Zp45
1F17
11
2
5.11
93
414
Bio
logi
cal_
proc
ess
unkn
own
Put
ativ
e un
char
acte
rized
pro
tein
DK
FZp5
47P
162
[Fra
gmen
t] D
KFZ
p547
P16
2 4
4.
86
3624
7 B
iolo
gica
l_pr
oces
s un
know
nP
utat
ive
unch
arac
teriz
ed p
rote
in D
KFZ
p564
P05
62 [F
ragm
ent]
DK
FZp5
64P
0562
5
5.
37
1520
88
Bio
logi
cal_
proc
ess
unkn
own
Put
ativ
e un
char
acte
rized
pro
tein
DK
FZp6
86A
1195
D
KFZ
p686
A11
95
3
6.33
18
9618
B
iolo
gica
l_pr
oces
s un
know
nP
utat
ive
unch
arac
teriz
ed p
rote
in D
KFZ
p686
B23
205
[Fra
gmen
t] D
KFZ
p686
B23
205
5
5.12
33
009
Bio
logi
cal_
proc
ess
unkn
own
Put
ativ
e un
char
acte
rized
pro
tein
DK
FZp6
86D
1012
6 [F
ragm
ent]
DKF
Zp68
6D10
126
2
4.77
14
872
Bio
logi
cal_
proc
ess
unkn
own
Put
ativ
e un
char
acte
rized
pro
tein
DK
FZp6
86L0
4275
[Fra
gmen
t] D
KFZ
p686
L042
75
9
9.21
53
969
Bio
logi
cal_
proc
ess
unkn
own
Put
ativ
e un
char
acte
rized
pro
tein
DK
FZp6
86M
0912
5 [F
ragm
ent]
DKF
Zp68
6M09
125
2
4.98
10
8618
B
iolo
gica
l_pr
oces
s un
know
nP
utat
ive
unch
arac
teriz
ed p
rote
in W
BS
CR
1 [F
ragm
ent]
WBS
CR
1 3
B
iolo
gica
l_pr
oces
s un
know
n 5.
19
1496
0R
NA
bin
ding
mot
if pr
otei
n, X
-link
ed-li
ke 1
[Fra
gmen
t] R
BMX
L1
2
10.3
0 16
850
Bio
logi
cal_
proc
ess
unkn
own
RN
T4
RTN
4
5 4.
52
1084
50
Bio
logi
cal_
proc
ess
unkn
own
R
ound
spe
rmat
id b
asic
pro
tein
1-li
ke p
rote
in
RSB
N1L
2
8.92
94
368
Bio
logi
cal_
proc
ess
unkn
own
S
CC
A-P
D v
aria
nt
Q8I
WL4
_HU
MAN
2
5.24
20
161
Bio
logi
cal_
proc
ess
unkn
own
si
mila
r to
Hom
o sa
pien
s N
-eth
ylm
alei
mid
e-se
nsiti
ve fa
ctor
atta
chm
ent p
rote
in, a
lpha
Q
6ZTL
0_H
UM
AN
2
5.02
15
808
Bio
logi
cal_
proc
ess
unkn
own
sim
ilar t
o H
YPO
THE
TIC
AL
GTP
-BIN
DIN
G P
RO
TEIN
IN S
EH
1-P
RP
20 IN
TER
GE
NIC
RE
GIO
N. [
Frag
men
t] Q
7L9H
8_H
UM
AN
4
5.58
73
142
Bio
logi
cal_
proc
ess
unkn
own
Sm
all V
CP
/p97
-inte
ract
ing
prot
ein
SV
IP
3
9.06
84
43
Bio
logi
cal_
proc
ess
unkn
own
Tran
scrip
tion
elon
gatio
n fa
ctor
A p
rote
in-li
ke 3
TC
EAL3
2
4.
85
2250
2 B
iolo
gica
l_pr
oces
s un
know
nTr
ipar
tite
mot
if-co
ntai
ning
pro
tein
2
TRIM
2 2
6.
51
8153
0 B
iolo
gica
l_pr
oces
s un
know
nU
ncha
ract
eriz
ed p
rote
in C
2orf3
2 C
2orf3
2 2
7.
72
1864
8 B
iolo
gica
l_pr
oces
s un
know
nU
ncha
ract
eriz
ed p
rote
in C
6orf1
74 [P
recu
rsor
] C
6orf1
74
2
5.81
10
3199
B
iolo
gica
l_pr
oces
s un
know
nU
ncha
ract
eriz
ed p
rote
in C
Xor
f23
CX
orf2
3
2
9.71
83
871
Bio
logi
cal_
proc
ess
unkn
own
unna
med
pro
tein
pro
duct
C
AH
0569
8 4
4.
84
2180
1 B
iolo
gica
l_pr
oces
s un
know
nun
nam
ed p
rote
in p
rodu
ct
CA
E99
312
3
8.62
12
182
Bio
logi
cal_
proc
ess
unkn
own
unna
med
pro
tein
pro
duct
C
AF0
0100
3
8.
79
1211
5 B
iolo
gica
l_pr
oces
s un
know
nun
nam
ed p
rote
in p
rodu
ct
CA
F064
70
3
11.4
2 39
586
Bio
logi
cal_
proc
ess
unkn
own
unna
med
pro
tein
pro
duct
C
AE
9014
1 2
5.09
37
545
n B
iolo
gica
l_pr
oces
s un
know
unna
med
pro
tein
pro
duct
C
AE
9942
8 2
5.05
14
510
n B
iolo
gica
l_pr
oces
s un
know
unna
med
pro
tein
pro
duct
C
AF0
0110
2
9.78
17
744
n B
iolo
gica
l_pr
oces
s un
know
unna
med
pro
tein
pro
duct
C
AF0
1554
2
11.5
5 66
42
n B
iolo
gica
l_pr
oces
s un
know
unna
med
pro
tein
pro
duct
C
AF8
6112
2
5.95
10
2932
n
Bio
logi
cal_
proc
ess
unkn
owun
nam
ed p
rote
in p
rodu
ct
CA
G29
885
2 10
.10
1949
4 n
Bio
logi
cal_
proc
ess
unkn
owun
nam
ed p
rote
in p
rodu
ct
CA
D61
726
3 9.
99
1146
6 n
B
iolo
gica
l_pr
oces
s un
know
unna
med
pro
tein
pro
duct
C
AE
1169
4 3
5.90
35
777
n
Bio
logi
cal_
proc
ess
unkn
owun
nam
ed p
rote
in p
rodu
ct
CA
D34
790
2 4.
75
1403
03
n
Bio
logi
cal_
proc
ess
unkn
owun
nam
ed p
rote
in p
rodu
ct
CA
D35
032
2 5.
42
4476
5 n
B
iolo
gica
l_pr
oces
s un
know
unna
med
pro
tein
pro
duct
C
AD
3512
5 2
8.23
20
711
n
Bio
logi
cal_
proc
ess
unkn
owun
nam
ed p
rote
in p
rodu
ct
CA
D61
740
2 9.
03
8255
n
B
iolo
gica
l_pr
oces
s un
know
unna
med
pro
tein
pro
duct
C
AD
6969
2 2
11.3
0 33
126
n
Bio
logi
cal_
proc
ess
unkn
owU
PF0
424
prot
ein
C1o
rf128
C
1orf1
28
2 5.
47
2417
8 n
Bio
logi
cal_
proc
ess
unkn
owW
D re
peat
-con
tain
ing
prot
ein
1 W
DR
1
2 6.
17
6619
4 n
Bio
logi
cal_
proc
ess
unkn
ow