REFERENCES

¯ Abirami, P., and Rajendran, A., (2012). GC-MS analysis of methanol extracts

of Vernonia cinerea. European Journal of Experimental Biology. 2 (1): 9-12.

¯ African Pharmacopoeia., (1986). Vol. 2. 1st ed. OAU/ STRC Publications. pp:

128-144.

¯ Ahuja, M.M.S., (1979). Epidemiological studies on diabetes mellitusin India.

In: Ahuja MMS, editor. Epidemiology of diabetes in developing countries.

New Delhi: Interprint. pp: 29-38.

¯ Ajabnoor, M.A., and Tilmisany, A.K., (1988). Effect of Trigonella foenum

graceum on blood glucose levels in normal and alloxan-diabetic mice. Journal

of Ethnopharmacology.22:45-49.

¯ Akah, P.A., Alemji, J. A., Salawu, O. A., Okoye, T. C. and Offiah, N .V.

(2009). Effects of Vernonia amygdalina on biochemical and hematological

parameters in diabetic Rats. Asian Journal of Medical Sciences, 1(3):108-113.

¯ Akyuz, M., Onganer, A.N., Erecevit, P., and Kirbag, S., (2010).Antimicrobial

activity of some edible mushrooms in the eastern and southeast Anatolia

region of Turkey. Gazi University Journal of Science. 23(2): 125-130.

¯ Alagammal, M., Rajalakshmi, K., and Mohan, V.R., (2012). Antidiabetic and

Antihyperlipidaemic activity of Polygala chinensis L whole plant in alloxan

induced diabetic rats International Journal of Chemical and Pharmaceutical

Sciences. 3 (3): 37- 44.

¯ Alberti, K.G.M.M., (1982). The biochemistry and the complication of

diabetes. In: Keen H, JavveJ (Eds). Complications of Diabetes. Edward

Arnold Publishers, London. 2: 31–70.

¯ Ali, M., (1985). Text book of Pharmacognosy. CBS Publishers and

Distributors, New Delhi, 1994. pp: 405.

¯ Almdal, T.P., and Vilstrup, H., (1987). Effects of streptozotocin induced

diabetes and diet on nitrogen loss from organs and on the capacity of urea

synthesis in rats, Diabetologia. 30: 952-956.

¯ Amin, R., Abdul-Ghani, A.S., Suleiman, M.S., (1987).Effect of Trigonella

feonum graecum on intestinal absorption. Proceedings of the 47th

Annual

Meeting of the American Diabetes Association (Indianapolis U.S.A.).

Diabetes. 36: 211a.

¯ Andlauer, W., and Furst, P., (1998). Antioxidative power of phytochemicals

with special reference to cereales. Cereal Foods World. 43:356-359.

¯ Anita, K., Malkit, N., and Rajbir, S., (2006). Proximate composition, available

carbohydrates, dietary fibre and anti nutritional factors of selected traditional

medicinal plants. Journal of Human Ecology. 19(3): 195-199.

¯ Annegowda, H.V. Ween Nee, C., Mordi, M.N., Ramanathan, S., and Mansor,

S.M ., (2010). Evaluation of phenolic content and antioxidant property of

hydrolysed extracts of Terminalia catappa L. leaf. Asian Jornal of plant

sciences. 9 (8): 479-485 ISSN 1682-3974.

¯ Ansarullah, Menaka, T., Ravirajsinh, J., Ranjitsinh, D., and Ramachandran,

A.V., (2009). Oreocnide integrifolia (gaud.)miq exhibits hypoglycemic and

hypolipidemic potentials on streptozotocin diabetic rats: a preliminary dose

and duration dependent study . Electronic journals library. 8: 97-106 ISSN

1611-2156.

¯ Anwar, M.M., and Meki, A.R., (2003). Oxidative stress instreptozotocin-

induced diabetic rats: effects of garlic oil and melatonin, Comparative

Biochemistry and Physiology Part A: Molecular and Integrative Physiology.

135(4): 539- 547.

¯ AOAC., (2005).Official methods of AOAC International. In: Current through

Revision 2, 2007, Howrtz, W and G.W. Latimer (Eds.). 18th

ed. Association of

official Analytical chemist International, Gaithersburg, MA., USA.

¯ Arivazhagan, P., Thilagavathy, T., and Pannerselvam, C., (2000). Antioxidant

lipoate and tissue antioxidants in aged rats. Journal of Nutritional

Biochemistry.11: 122–127.

¯ Aruoma, O.I., and Cuppett, S.L., (1997). Antioxidant methodology invivo and

invitro concepts. AOCS press, champaign, Illinois. 41-172.

¯ Asaba, K., Tojo, A., Onozato, M.L., Goto, A., and Quinn, M.T., Fujita, T., and

Wilcox, C.S., (2005). Effects of NADPH oxidase inhibitor in diabetic

nephropathy. Kidney International. 67: 1890–1898.

¯ Asayama, K., Nakana, T., Uchida, N., Hayashibe, H., Dobashi, K., and

Nakazawa, S., (1994). Serum antioxidant status in streptozotocin-induced

diabetic rat. Hormone and Metabolic Research. 26: 313-315.

¯ Asfors, K.E., and Ley, K., (1993).Sulfated polysaccharides in inflammation.

Journal of Laboratory and Clinical Medicine. 121: 201-202.

¯ Ashok Kumar, P., Rajkumar, and Kanimozhi, M., (2010) Phytochemical

screening and antimicobial activity from five Indian medicinal plants against

human pathogens. Middle-East Journal of Scientific Research. 5 (3):157-162

ISSN 1990-9233.

¯ Asmena Mowla, M., Alauddin, M.D., Atiar, R., and Kabir, A., (2009).

Antihyperglycemic effect of Trigonella foenum-graecum (Fenugreek) seed

extract in alloxan-induced diabetic rats and its use in diabetes mellitus: a brief

qualitative phytochemical and acute toxicity test on the extract. African

Journal of Traditional Complementary and Alternative Medicines. 6 (3): 255 –

261.

¯ Ayed, Al- L., and Talal, Z., (2011). Long-term effects of Nigella sativa L. oil

on some physiological parameters in normal and streptozotocin-induced

diabetic rats. Journal of Diabetes Mellitus.1 (3):46-53.

¯ Bangar, O. P., Jarald, E., Asghar, S., and Ahmad, S., (2009). Antidiabetic

activity of a poly herbal formulation (Karnim Plus). International Journal of

Green Pharmacy. 3 (3): 211–214.

¯ Better, O.S, Stein, J.H., (1990). Early management of shock and prophylaxis

of acute renal failure in traumatic rhabdomyolysis. New England Journal of

Medicine. 322:825-829.

¯ Beulter, E., Duron, O., and Kelly, B.M., (1963). Improved method for the

determination of blood glutathione. Journal of Laboratory and Clinical

Medicine. 61: 882-888.

¯ Bhalodi, M., Shukla, S., and Saluja, A.K., (2005). In-vitro Antioxidant activity

of the flowers of Ipomoea aquatica Forsk. Pharmacognosy Magazine. 4: 226–

230.

¯ Block, K., Gorin, Y., and Abboud, H.E., (2009). Subcellular localization of

Nox4 and regulation in diabetes. Proceedings of the National Academy of

Sciences of the United States of America. 106 (34): 14385–14390.

¯ Blois, M.S., (1958). Antioxidant determination by the use of stable free

radical. Nature. 181 (4617) pp: 1199-1200.

¯ Bobek, P., and Galbavy, S., (2001). Effect of pleuran (β-glucan from

Pleurotus ostreatus) on the antioxidant status of the organism and on dimethyl

hydrazine induced precancerous lesions in rat colon. British Journal of

Biomedical Science .58: 164-168.

¯ Bobek, P., and Ozdin, L., (1996). Oyster mushroom (Pleurotus ostreatus)

reduces the production and secretion of very low density lipoproteins in hyper-

cholesterolemic rats. Zeitschrift Ernahrungswiss. 35: 249-252.

¯ Bobek, P., Kuniak, L., and Ozdin, L., (1993). The mushroom Pleurotus

ostreatus reduces secretion and accelerates the fractional turnover rate of very-

low-density lipoproteins in the rat. Annals of Nutrition and Metabolism. 37(3):

142-145.

¯ Bobek, P., Ozdin, L., and Kuniak, L., (1997). Effect of Oyster mushroom and

isolated β-glucan on lipid peroxidation and on the activities of antioxidative

enzymes in rats fed the cholesterol diet. Journal of Nutritional Biochemistry.

8: 469-471.

¯ Brandt, C.R., and Piraino, F., (2000). Mushroom antivirals. Recent Research

Developments for Antimicrobial Agents and Chemotherapy. 4: 11-16.

¯ Buddi, R., Lin, B., Atilano, S.R., and Zorapapel, N.C., Kenney, M.C., and

Brown, D.J., (2002). Evidence of oxidative stress in human corneal diseases.

Journal of Histochemistry and Cytochemistry. 50: 341-51.

¯ Bukhup, L., and Samappito, S., (2011). Invitro free radical scavenging and

antimicribial activity of some selected thai medicinal plants. Research Journal

of Medicinal Plant. 5 (3):254-265.

¯ Cayen, M.N., and Dvornik, D., (1979). Effect of diosgenin on lipid

metabolism in rats. Journal of Lipid Research. 20: 162–174.

¯ Cemek, M., Kaga, S., Simesk, N., Buyuuko kuroglu, M.E., and Konuk, M.,

(2008). Antihyperglycaemic and antioxidative potential of Matricaria

chamomilla L. in streptozotocin –induced diabetic rats. Nature Medicine. 62

(3):284-293.

¯ Ceriello, A., Quatraro, A., and Giugliano, D., (1992). New insight on non-

enzymatic glycosylation may lead to therapeutic approaches for the prevention

of the diabetic complications. Diabetic Medicine.9: 297-299.

¯ Chakravarthy, B.K., Gupta, S., and Gambir, K.D., (1980). Pancreatic beta cell

regeneration: A novel antidiabetic mechanism of Petercarpus

marsupium. Indian Journal of Pharmacology. 12:123–128.

¯ Chang, C.C., Yang, M, H., Wen, H.M., and Chern, J. C., (2002).Estimation of

total flavonoid content in propolis by two complementry colorimetric

methods. Journal of Food Drug Analysis. 10: 178-182.

¯ Chang, S.T., and Buswell, J.A., (1996). Mushroom nutriceuticals. World

Journal of Microbiology and Biotechnology. 12: 473-476.

¯ Chitravadivu, C., Manian, S., and Kalaichelvi, K., (2009). Qualitative analysis

of selected medicinal plants Tamilnadu, India. Middle-East Journal of

Scientific Research . 4(3): 144-146.

¯ Choi, D.B., Cha, W.S., Kang, S.H., and Lee, B.R., (2004). Effect of Pleurotus

ferulae extracts on viability of human lung cancer and cervical cancer cell

lines. Biotechnology and Bioprocess Engineering. 9: 356-361.

¯ Chung, K., Wong T.Y., Wei, C., Huang, Y.w., Lin, Y., (1998). Tannins and

Human Health: A Review.Critical Reviews in Food Science and Nutrition.

38: 421–464.

¯ Cohen, R., Persky, L., and Hadar Y. P. L., (2002). Biotechnical applications

and potential of wood-grading mushrooms of the genus Pleurotus. Applied

Microbiology and Biotechnology. 58: 582-594.

¯ Cragg, G.M, and David, J.N., (2001). Natural product drug discovery in the

next millennium. Journal of Pharmaceutical Biology. 39: 8-17.

¯ Cvetkoviae, T., Mitiae, B., Lazareviae, G., and Vlahoviae, P., Antiae, S., and

Stefanoviae, V., (2009). Oxidative stress parameters as possible urine markers

in patients with diabetic nephropathy. Journal of Diabetes and its

Complications. 23: 337-342.

¯ Daba, A.S., and Ezeronye, O.U., (2003). Anti-cancer effect of polysaccharides

isolated from higher basidiomycetes mushrooms. African Journal of

Biotechnology. 2 (12): 672-678.

¯ Dash, B.K., Sultana, S., and Sultana, N., (2011). Antibacterial activities of

methanol and acetone extracts of fenugreek (Trigonella foenum) and

Coriander (Coriandrum sativum). Life Sciences and Medicine Research.

LSMR-27.

¯ Debasis, De, Kausik Chatterjee, Kazi Monjur Ali, and Tushar Kanti Bera,

Debidas Ghosh., (2011). Antidiabetic Potentiality of the Aqueous-Methanolic

Extract of Seed of Swieteniamahagoni (L.) Jacq. in Streptozotocin-Induced

Diabetic Male Albino Rat: A Correlative and Evidence-Based Approach with

Antioxidative and Antihyperlipidemic Activities. Evidence-Based

Complementary and Alternative Medicine, Article ID 892807, 11 pages

doi:10.1155/2011/892807.

¯ Dhruv, K Singh., Peter, W., and Farrington, K., (2011). Oxidative stress in

early diabetic nephropathy: fueling the fire. Nature Reviews Endocrinology.7:

176–184 doi:10.1038/nrendo.2010.212.

¯ DO Edem, Ekanem, I. S., and Ebong, P. E., (2009). Effect of aqueous extracts

of alligator pear seed (Persea americana mill) on blood glucose and

histopathology of pancreas in alloxan-induced diabetic rats. Pakistan Journal

of Pharmaceutical Sciences.22 (3):272-276.

¯ Dunlop, M., (2000). Aldose reductase and the role of the polyolpathway in

diabetic nephropathy. Kidney international Supplement. 58 (77): pp S3–S12.

¯ Easu, K., (1964). Plant anatomy. Jhon Wiley and Sons, New York, pp: 767.

¯ Elmastas, M., Gulcin, I., Isildak, O., Kufrevioglu, O.I., Ibaoglu, K., and

Aboul-Enein, H.Y. (2006). Radical scavenging activity and antioxidant

capacity of bay leaf extracts. Journal of the Iranian Chemical Society. 3(3):

258–266.

¯ Emanuel Vamanu., (2012). In vitro antimicrobial and antioxidant activities of

ethanol lyophilized mycelium of Pleurotus ostreatus PQMZ91109. Molecules.

17 (4): 3653-3671.

¯ Emmons, C. L., Peterson, D. M., and Paul, G. L., (1999). Antioxidant capacity of

oat (Avena sativa L.) extracts. 2. In vitro antioxidant activity and contents of

phenolic and tocopherol antioxidants. Journal of Agricultural and Food

Chemistry. 47: 4894-4898.

¯ Erdos, E.G., (1976). Conversion of angiotensin I to angiotensin II. The

American Journal of Medicine . 60 (6): 749-759.

¯ Evans, W.C., and Saunders, W.B., (Eds.) (2001). Trease and Evan’s

Pharmacognosy Tokyo. pp: 1- 579.

¯ Eze, E.D., Mohammed, A., Musa K.Y., and Tanko, Y., (2012). Evaluation of

Effect of ethanolic leaf extract of Mucuna pruriens on blood glucose levels in

alloxan-Induced diabetic Wistar rats. Asian Journal of Medical Sciences. 4(1):

23-28.

¯ Farrugia, D. L., Shoemake, C. M., Attard, E., and Azzopardi, L. M., Mifsud

S.J., (2013). Investigative study on the angiotensin converting enzyme (ACE)

inhibiting properties of the terpenoid extract of Crataegus monogyna using

insilico models. Journal of Pharmacognosy and Phytotherapy. 5 (2): 34-37.

¯ Feldmann, M., Brennan, F.M., and Maini, R.N., (1996 b) Role of cytokines in

rheumatoid arthritis. Annual Review of Immunology. 14:397– 440.

¯ FND., (2002). Food and Nutrition Board, Institute of medicine. National

Academy of Sciences. Dietary reference intake for energy, carbohydrate, fibre,

fat, fatty acids, cholesterol, protein and amino acid (micro-nutrients);

www.nap.edu (Retrieved on 14/05/2007).

¯ Forbes, J.M., Cooper, M.E., Oldfield, M.D., and Thomas, M.C., (2003). Role

of advanced glycation end products in diabetic nephropathy. Journal of

American Society of Nephrology. 14: S254–S258.

¯ Formica, J.V., and Regelson, W., (1995) Review of the biology or quercetin

and related biflavonoids. Food Chemistry Toxicology. 33: 1061-1080.

¯ Foyer, C.H., Lelandias, M., Edwards, E.A., and Mullineaux, P. M., (1991).

Current topics in plant physiology, 6, ASPP, Rockville. 131.

¯ Franke, S., Sommer, M., Ruster, C., Bondeva, T., and Marticke, J., Hofmann,

G., et al., (2008). Advanced glycation end-products induce cell cycle arrest

and hypertrophy in podocytes. Nephrology Dialysis Transplantation. . 23:

2179–2191.

¯ Fu, H.Y., Shieh, D.E., and Ho, C.T., (2002). Antioxidant and free radical

scavenging activities of edible mushrooms. Journal of Food Lipids. 9: 35-43.

¯ Ganesh, C.J., and Manjeshwar, S.B., (2004). The evaluation of nitric oxide

scavenging activity of certain Indian medicinal plants invitro: A preliminary

study. Journal of Medicinal Food. 7(3): 343-348.

¯ Garrat., D.C., (1964). The quantitative analysis of drugs. Chapman & Hall

Ltd. Japan. Vol. 3, pp: 456-458.

¯ Geetha, M., Suneel, K.R., Krupanidhi, A.M., Muralikrishna, K.S., and Avin,

A. P., Prashanth, P., (2011). Effect of Fenugreek on total body and organ

weights: A Study on mice. Pharmacologyonline. 3: 747-752.

¯ Gerasimenya, V.P., Efremenkova, O.V., Kamzolina, O.V., and Bogush, T.A.,

Tolstych, I.V., and Zennkova, V.A., (2002). Antimicrobial and anti toxical

action of edible and medicinal mushroom Pleurotus ostreatus (Jacq,:Fr.)

Kumm. Extracts. International Journal of Medicinal Mushrooms. 127-132.

¯ Gilbert, R.E., Cox, A., Wu, L.L., Allen, and T.J., Hulthen, U.L., Jerums, G.,

Cooper, M.E., (1998). Expression of transforming growth factor-beta1 and

type IV collagen in the renal tubulointerstitium in experimental diabetes:

Effects of ACE inhibition. Diabetes. 47: (3) 414-422.

¯ Gokhale, S.G., Kokate, C.K., and Purohit, A.P., (2003).A text Book of

Pharmacognosy, Nirali Prakashan, Pune.

¯ Gregori, A., Svagelj, M., and Pohleven, J., (2007). Cultivation techniques and

medicinal properties of Pleurotus spp. Food Technology and Biotechnology.

45 (3): 238-249.

¯ Griendling, K.K., Minieri, C.A., Ollerenshaw, J.D., and Alexander, R.W.,

(1994). Angiotensin II stimulates NADH and NADPH oxidase activity in

cultured vascular smooth muscle cells. Circulation Research.74 (6): 1141–

1148.

¯ Gunde-Cimerman, N., and Plemenitas, A., (2001). Hyporcholesterolemic

activity of the genus Pleurotus (Jacq.: Fr.) P. Kumm.(Agaricales s. l.,

Basidiomycetes) International Journal of Medicinal Mushrooms.3: 395-397.

¯ Gunde-Cimerman, N. Friedrich, J., Cimerman, A., and Benicki, N., (1993).

Screening fungi for the production of an inhibitor of HMG CoA reductase:

Production of mevinolin by the fungi of the genus Pleurotus. Federation of

European Microbiological Societies Microbiology. Letters. 111: 203-206.

¯ Ha, H., and Kim, K.H., (1992). Amelioration of diabetic micro albuminuria

and lipid peroxidation by captopril. Yonsei Medical Journal. 33:217–223.

¯ Halliwell, B., (1991) Reactive oxygen species in living systems: Source,

biochemistry and role in human disease. American Journal of Medicine.91:

14-22.

¯ Handa, S.S., and Kapoor, V.K., (Eds.) 1992. Pharmacognosy Vallabah

Prakashan Publications, New Delhi. pp: 51.

¯ Handa, T., Yamaguchi, K., Sono, Y., and Yazawa, K., (2005). Effects of

fenugreek seed extract in obese mice fed a high-fat diet. Bioscience-

Biotechnology-and-Biochemistry.69 (6):1186 –1188.

¯ Harborne, J.B., (1984). Phytochemical Methods, A guide of modern

techniques of plant analysis, Chapman and hall, 2nd

ed. London.

¯ Harborne, J.B., and Williams, C.A., (2000). Advances in flavonoid research

since 1992. Phytochemistry. 55: 481-504.

¯ Hatapakki, B.C., Suresh, H.M., Bhoomannaver, V., and Shivkumar, S.I.,

(2005). Effect of Cassia auriculata Linn. flowers against alloxan induced

diabetes in rats. Journal of Natural Remedies .5 (2): 132-136.

¯ Hayath Basha, S. K., and Subramanian, S. (2011).Biochemical evaluation of

antidiabetic and antioxidant potentials of annona squamosa leaves extracts

studied in stz induced diabetic rats Indian Journal of Pharmaceutical Science

and Research 2(3): 643-655.

¯ Hedge, J.E., and Hofreiter, B.T., (1962). In: Carbohydrate chemistry, 17 (Eds.

Whitler RL and Be Miller JN), Academic press New York.

¯ Hochestein, P., and Atallah, A.S., (1988). The nature of antioxidant systems in

the inhibition of mutation and cancer. Mutation Research. 202: 363-375.

¯ Horiuchi, M., Akishita, M., and Dzau V.J., (1999). Recent progress in

angiotensin II type 2 receptor research in the cardiovascular system.

Hypertension. 33: 613-621.

¯ Hoskote, S.S, and Joshi, S.R., (2008). Are Indians Destined to be Diabetic?

Journal of Associations of Physicians of India. 56: 225–226.

¯ Hossain, S., Hashimoto, M., Choudhury, E.K., and Alam, N., and Hussain, S.,

Hasan, M., Choudhury, S.K., and Mahmud, I., (2003). Dietary mushroom

(Pleurotus ostreatus) ameliorates atherogenic lipid in hyper- cholesterolaemic

rats. Clinical and Experimental Pharmacology and Physiology. 30: 470-475.

¯ Hosseini-Zijoud Seyed, M., Hosseini, J., Mahmoodi, M., Gholamhossein, H.,

Behrooz, H., and Hosseini-zijoud Seyed, M., (2012).The effects of Persian

shallot extract on the levels of some blood biochemical parameters in

streptozotocininduced diabetic rats. African Journal of Agricultural Research

7(22): 3308-3313 doi: 10.5897/AJAR11.2498 ISSN 1991-637X

¯ Huang, S., and Kuo, J.C., (2000).Concentrations and antioxidant activity of

anserine and carnosine in poultry meat extracts treated with demineralization

and papain. Proceedings of the Natural Science Council, Republic of China -

(Part B). 24(4); 193-201.

¯ Hui-Yu, H., Mallikarjuna, K., Ying-Ying, C., Ting-Yi, C., and Ying-Chieh, T.,

(2012). Pleurotus tuber-regium polysaccharides attenuate hyperglycemia and

oxidative stress in experimental diabetic rats. Evidence-Based Complementary

and Alternative Medicine, Article ID 856381, 8 pages

doi:10.1155/2012/856381.

¯ Hyun-Jeong, K., In-Gyeong, C., Sung-Gyu, L., Hyun-Jin, J., Eun-Ju, L., and

In-Seon, L., (2010). Effects of fermented red ginseng extracts on

hyperglycemia in Streptozotocin-induced diabetic Rats. Journal of Ginseng

Research. 34 (2):104-112.

¯ Ichiki, T., Kambayashi, Y., and Inagami, T., (1995). Multiple growth factors

modulate mRNA expression of angiotensin II type-2 receptor in R3T3 cells.

Circulation Research. 77: 1070-1076.

¯ Irina, C., Chis, Marius I., Ungureanu, Adriana M., and, Ramona S., Adriana

M., Ion-Dan P., and Nicoleta D., (2009). Antioxidant effects of a grape seed

extract extract in a rat model of diabetes mellitus. Diabetes and Vascular

Disease Research. 6 (3): 200–204.

¯ Ishigaki, N., Yamamoto, T., Shimizu, Y., Kobayashi, K., and Yatoh, S., Sone,

H., Takahashi, A., Suzuki, H., Yamagata, K., Yamada, N., Shimano, H.,

(2007). Involvement of glomerular SREBP-1c in diabetic nephropathy.

Biochemical and Biophysical Research. Communications . 364 (3): 502–508.

¯ Item Justin, A., Ime Franklin, A., Margaret Akpana, A., Grace Sylvester, E.,

and Patrick Ekong, E., (2010). Comparative effect of chlorpropamide and

combined leaf extracts of Azadirachta indica and Vernonia amygdalina on

blood glucose and biochemical parameters of alloxanized rats

Journal of Medical Sciences. 1 (6): 243-253.

¯ Iwalokun, B.A., Usen, U.A., Otunba, A.A., and Olukoya, D.K., (2007).

Comparative phytochemical evaluation, antimicrobial and antioxidant

properties of Pleurotus ostreatus. African Journal of Biotechnology. 6: 1732-

1739.

¯ James, H. O'Keefe, J.r., MD, Becky K., Captain, R.N., Philip G., Jones, M.S.,

and William Harris S., (2004). Atrovastatin reduces remnant lipoproteins and

small, dense low-density lipoprteins regardless of the baseline lipid pattern.

Preventive Cardiology.7 (4): 154-160.

¯ Jasmine, R., and Daisy, P., (2011). Regeneration of the β-cells in the islets of

langerhans by Eugenia Jambolana in streptozotocin diabetic rats.

Pharmacologyonline. 3: 283-289.

¯ Javanmardi, J., Stushnoff, C., Locke, E., and Vivanco, J.M., (2003).

Antioxidant activity and total phenolic content of Iranian Ocimum accessions.

Food Chemistry. 83:547-550.

¯ Kaleem, M., Kirmani, D., Asif, M., Ahmed, Q., and Bano B., (2006).

Biochemical effects of Nigella sativa L seeds in diabetic rats. Indian Journal

of Experimental Biology .44(9):745-748.

¯ Kalinyak, J.E., Sechi, L.A., Griffin, C.A., and Don, B.R., Tavangar, K.,

Kraemer, F.B., Hoffman, A.R., and Schambelan, M., (1993). The renin-

angiotensin system in streptozotocin-induced diabetes mellitus in the rat.

Journal of American Society of Nephrology. 4: 1337-1345.

¯ Kamal Adel, A., Ezzat Mohamed, A., and Mohammed Ahmad, N., (2011).

Effects of Panax quinquefolium on streptozotocin-induced diabetic rats: role

of C-peptide, nitric oxide and oxidative stress. International Journal of

Clinical and Experimental Medicine. 4(2):136-147.

¯ Kambayashi, Y., Nagata, K., Ichiki, T., and Inagami, T., (1996). Insulin and

insulin-like growth factors induce expression of angiotensin type-2 receptor in

vascular-smooth-muscle cells. European Journal of Biochemistry. 239 (3):

558-565.

¯ Kaviarasan, S., Naik, G.H., Gangabhagirathi, R., Anuradha, C.V, and

Priyadarsini, K.I., (2007). Invitro studies on antiradical and antioxidant

activities of fenugreek (Trigonella foenum graecum) seeds. Food Chemistry.

103(1):31–37.

¯ Kelly, D.J., Buck, D., Cox, A.J., Zhang, Y., and Gilbert, R.E., (2007). Effects

on protein kinase C- inhibition on glomerular vascular endothelial growth

factor expression and endothelial cells in advanced experimental diabetic

nephropathy. American Journal of Physiology Renal Physiology. 293 (2):

F565–F574.

¯ Kelvin, R., and Moss, S., (1992). Visual impairment and diabetes, In Albert K,

De Fronzo Keen R, Zimmet Eds HP, 2002. International Textbook of Diabetes

Mellitus. Chi Chester: Wiley. 1373-1384.

¯ Keyhani, J., Keyhani, E., and Arzi, L., (2007). Anti-oxidative stress enzymes

in Pleurotus ostreatus. Acta Horticulturae. 739: 420-427.

¯ Kim, J.H., Kim, S.J., Park, H.R., Choi, J.I., Ju, Y.C., Nam, K.C., Kim, S.J.,

and Lee, S.C., (2009). The different antioxidant and anticancer activities

depending on the colour of oyster mushrooms. Journal of Medicinal Plants

Research. 3 (12): 1016-1020.

¯ Kim, Y.S., Kim, B.C., Song, C.Y., Hong, H.K., Moon, K.C., and Lee,

H.S.,(2001). Advanced glycosylation end products stimulate collagen mRNA

synthesis in mesangial cells mediated by protein kinase C and transforming

growth factor. Journal of Laboratory and Clinical Medicine. 138: 59–68.

¯ Korycka-Dhal, M., and Richardson, T., (1978). Photogeneration of superoxide

anion in serum of bovine milk and in model systems containing riboflavin

and aminoacid. Journal of Dairy Science. 61:400-407.

¯ Kotra, L.P., and Mobashery, S., (1998). β-lactam antibiotics, β-lactamases and

bacterial resistance . Bulletin de l Institut Pasteur. 96: 139-150.

¯ Koya, D., Jirousek, M.R., Lin, Y.W., and Ishii, H., Kuboki, K., and King,

G.L., (1997). Characterization of protein kinase C beta isoform activation on

the gene expression of transforming growth factor-beta, extracellular matrix

components, and prostanoids in the glomeruli of diabetic rats. Journal of

Clinical Investigation. 100: 115–126.

¯ Koyama, T., Chounan, R., Uemura, D., and Yamaguchi, K., and Yazawa, K.,

(2006). Hepatoprotective effect of a hot water extract from the edible thorny

oyster Spondylus varius on carbon tetrachloride induced liver injury in mice.

Bioscience Biotechnology and Biochemistry .70 (3): 729-731.

¯ Kubmarawa, D., Ajoku, G.A., Enworem, N.M., and Okorie, D.A., (2007).

Roles of agricultural biotechnology in ensuring adequate food security in

developing societies. African Journal of Biotechnology. 6: 1690-1696.

¯ Kumarappan, C. T., Rao, T. N., and Mandal, S. C., (2007). Polyphenolic

extract of Ichnocarpus frutescens modifies hyperlipidemia status in diabetic

rats. Journal of Cell and Molecular Biology. 6:175–187.

¯ Lakshmi, B., Jose, N., Ajith, T.A., and Jananrdhanan, K.K., (2004).

Antimutagenic activity of methanolic extract of culinary-medicinal oyster

mushroom, Pleurotus ostreatus (Jacq.: Fr.) Kumm (strain floric Eger nom.

Nud.) and its protective effect against benzo(á) pyrene-induced hepatic

damages International Journal of Medicinal Mushrooms. 6: 139-149.

¯ Lala, P.K., (1998). Significance of nitric oxide in carcinogenesis, tumor

progression and cancer therapy. Cancer and Metastasis Reviews.17: 1- 6.

¯ Ledwozxy, A., Michalak, J., Stepien, A., and Kadziolka, A., (1986). The

relationship between plasma triglycerides, cholesterol, total lipids and lipid

peroxidation products during human atherosclerosis.Clinica chemica Acta.

155 (3): 275-284.

¯ Lee, E.W., He, P., Kawagishi, H., and Sugiyama, K., (2000). Suppression of

D-galactosamine induced liver injury by mushroom in rats. Bioscience,

Biotechnology, and Biochemistry. 64(9): 2001-2004.

¯ Lee, K.G., Mitchell, A.E., and Shibamoto, T., (2000). Determination of

antioxidant properties of aroma extracts from various beans. Journal of

Agricultural and Food Chemistry. 48: 4817-4820.

¯ Li, H., Hao, Z., Wang, X., Huang, L., and Li, J., (2009).Antioxidant activities

of extracts and fractions from Lysimachia foenum-graecum Hance.

Bioresource Technology. 100: 970–974.

¯ Li, Y.R., Liu Q.H. Wang, H.X., and Ng, T.B., (2008). A novel lectin with

potent antitumor, mitogenic and HIV-1 reverse transcriptase inhibitory

activities from the edible mushroom Pleurotus citrinopileatus. Biochimica et

Biophysica Acta (BBA) – General Subjects.1780(1): 51-57.

¯ Lindequist, U., Niedermeyer, T.H.J., and Julich, W.D., (2005).

Pharmacological potential of mushrooms. Evidence-Based Complementary

and Alternative Medicine. 2: 285-299.

¯ Lino Cde, S, Diógenes, J.P., Pereira, B.A., Faria, R.A., Andrade, N.M., Alves,

R.S., de Queiroz, M.G., de Sousa, F.C., and Viana G.S., (2004). Antidiabetic

activity of Bauhinia forficata extracts in alloxan-diabetic rats. Biological and

Pharmaceutical Bulletin. 27(1): 125-127.

¯ Liu, F., Oovi, V.F.C., and Chang, S.T., (1997). Free radicals scavenging

activity of mushroom polysaccharide extracts. Life Science. 60:763-777.

¯ Liu, I. M., Hsu, F. L., Chen, C. F., and Cheng, J. T., (2000)

Antihyperglycemic action of isoferulic acid in streptozotocin-induced diabetic

rats, British Journal of Pharmacology. 129 (4):631–636.

¯ Luka Carrol, D., Mohammed, A., and Saleh, B., (2012). Effect of aqueous

extract of Helianthus annus on some biochemical parameters in alloxan-

induced diabetic rats Journal of Natural Product and Plant Resources. 2 (1):

186-191.

¯ Mabo-salema, O.H., El-Edel, R., Iharisa, G.E., El-Halawany, N., and

Ghonaim, M.M., (2009). Experimental diabetic nephropathy can be prevented

by propolis: Effect on metabolic disturbances and renal oxidative parameters.

Pakistan Journal of Pharmaceutical Sciences. 22 (2): 205-210.

¯ Madway, W., Prier, L.E., and Wilkinson, J.S., (1969). A text book of

veterinary clinical pathology, The Williams wilking Co. Battimore.

¯ Maiti, S., Mallick, S.K., Bhutia, S.K., Behera, B., Mandal, M., and Maiti,

T.K., (2011). Antitumor effect of culinary-medicinal oyster mushroom,

Pleurotus ostreatus (Jacq.: Fr.) derived protein fraction on tumor-bearing mice

models. International Journal of Medicinal Mushrooms. 13: 427-440.

¯ Makkar, H.P.S., Blummel, M., Borowy, N.K., and Becker, K., (1993).

Gravimetric determination of tannins and their correlation with chemical and

protein precipitation methods. Journal of Science Food & Agriculture. 61:161-

165.

¯ Mallikharjuna, P.B., Rajanna, L.N., Seetharam, Y.N., and Sharanabasappa,

G.K., (2007). Phytochemical studies of Strychonos potatorum L.f. - A

Medicinal plant. European Journal of Chemistry. 4(4): 510-518.

¯ Marcocci, L., Maguire, J.J., Droy-Lefai, M.T., and Parker, L., (1994). Nitric

oxide scavenging activity of Ginkgo biloba extracts EGb761. Biochemical and

Biophysical Research Communications. 201: 748-755.

¯ Marles, R.J., and Farnsworth, N.R., (1995). Antidiabetic plants and their

active constituents. Phytomedicine. 2 :(2)137-189. doi: 10.1016/S0944-

7113(11)80059-0

¯ McCue, P., Shetty, K., (2004). Inhibitory effects of rosmarinic acid extracts on

porcine pancreatic amylase invitro. Asia Pacific Journal of Clinical Nutrition.

13(1):101-106.

¯ Meir, S., Kanner, J., Akiri, B., and Hadas, S.P., (1995). Determination and

involvement of aqueous reducing compounds in oxidative systems of various

senescing leaves. Journal of Agricultural and Food Chemistry. 43: 1813-1819.

doi: 10.1021/jf00055a012

¯ Middleton, E., Kandaswami, C., and Theoharides, T.C., (2000). The effects of

plants flavonoid on mammalian cell: implication for inflammation, heart

disease, and cancer. Pharmacological Reviews. 52 (4):673-751.

¯ Misra, H.P., and Fridovich, I., (1972). The role of superoxide anion in the

auto-oxidation of epinephrine and a simple assay for superoxide dismutase.

Journol of Bilogical Chemistry. 247: 3170- 3175.

¯ Miyamato, K., Khosrof, S., Bursell S.E., Rhoan, R., Murata, T., Clermont, A.,

Aiello, L.P., Ogura, Y., and Adamis, A.P., (1999). Prevention of leukostasis

and vascular leakage in streptozotocin-induced diabetic retinopathy via

intrecellular adehesion molecule-1inhibition. Proceedings of the National

Academy of Sciences. USA.96; 10836-10841.

¯ Miyazawa, N., Okazaki, M., and Ohga, S., (2008) Antihypertensive Effect of

Pleurotus nebrodensis in spontaneously hypertensive rats. L. Oleo Science.

57(12): 675-681.

¯ Mahmoodi, M., Hosseini-Zijoud, S.M., Hassanshahi G.H., Toghroli M.A.,

Khaksari, M., Hajizadeh, M.R., and Mirzajani, E., (2011). The effects

ofconsumption of raw garlic on serum lipid level, blood sugar and anumber of

effective hormones on lipid and sugar metabolism inhyperglycemic and/or

hyperlipidemic individuals. Advances in Biological Chemistry. 1(2): 29-33.

¯ Mohamed Farook, S., and Clement Atlee, W., (2011). Antidiabetic and

hypolipidemic potential of Tragia involucrata linn on streptozotocin -

nicotinamide induced type II diabetic rats. International Journal of Pharmacy

and Pharmaceutical Sciences. 3 (4): 103-109. ISSN- 0975-1491.

¯ Mokhtari, M., Sharifi, S., and Shahamir Tabatabaee, M., (2011).The effect of

hydro – alcoholic seeds extract of Ceratonia siliqua on the blood glucose and

lipids concentration in diabetic male rats. International Conference on Life

Science and Technology. 3:82-86.

¯ Morcos, S.R., Elhawary, Z., and Gabrial, G.N., (1981). Protein rich food

mixtures for feeding the young in Egypt. 1. Formulation.

Zeitschrift Ernahrungswiss. 20 (4):275-282.

¯ Morschhauser, J.G., Kohler, W., Ziebuhr, G., Blum Oehler, U., Dobrindt and

Hacker, J., (2000). Evolution of microbial pathogens. Philosophical

Transactions of the Royal Society Lond. B. 355: 695-704.

¯ Muhammad, Z., Syed Naeem-ul-Hassan N., Masood A., and Zahid Ali K.,

(2009). Altered kidney morphology and enzymes in streptozotocin

induced diabetic rats. International Journal of Morphology. 27(3):783-790.

¯ Mukharjee, P.K., (2005). Quality Control of Herbal Drugs: An approach to

evaluation of botanicals. Business HorizonsPharmaceutical Publishers. New

Delhi, pp: 131-196.

¯ Muralidhara, N.K., Viswanatha, S., and Ramesh, B.S., (1999). Acute and

subchronic toxicity assessment of debitterized fenugreek powder in the mouse

and rat. Food and Chemical Toxicology. 37:831-838.

¯ Nanba, H., (1993). Maitake mushroom the king mushroom. Mushroom News.

41(2): 22-25.

¯ Narendhirakannan, R.T., Subramonian, S., and Kandaswamy, M., (2006).

Biochemical evaluation of antidiabetogenic properties of some commonly

used Indian plants on streptozotocin-induced diabetes in experimental rats.

Clinical and Experimental Pharmacology and Physiology. 33 (12):1150–

1157.

¯ Nishikawa, T., Edelstein, D., Du, X.L., Yamagishi, S., and Matsumura, T.,

Kaneda. Y., Yorek, M. A., Beebe, D., Oates, P. J., Hammes, H.P., Giardino, I.,

and Brownlee, M., (2000). Normalizing mitochondrial superoxide production

blocks three pathways of hyperglycaemic damage. Nature .13 404(6779):

787–790.

¯ Nithya, R., and Ragunathan, R., (2009). Synthesis of silver nanoparticle using

Pleurotus Sajor- caju and its antimicrobial study. Digest Journal of

Nanomaterials and Biostructures. 4 (4): 623-629.

¯ Nonaka, A., and Manabe, T., (1991). Effect of new synthetic ascorbic acid

derivative as a free radical scavenger on the development of acute pancreatitis

in mice. International journal in gastroenterology and hepatology. 32 (5):

528-532.

¯ Nooman, A., Khalaf, Ashok, K., Shakya Atif Al, O., Zaha El, a., and Husni F.,

(2008). Antioxidant activity of some common plants. Turkish Journal of

Biology. 32:51-55.

¯ Nosalova, V., Bobek, P., Cerná, S., Galbavý, S., and Stvrtina, S., (2001).

Effects of pleuran (β-glucan isolated from Pleurotus ostreatus) on

experimental colitis in rats. Physiological Research. 50: 575-581.

¯ Nuhu, A., Ki Nam, Y., Kyung Rim, L., Pyung Gyun, S., Jong Chun, C.,

Young Bok, Y., Mi Ja S., Min Woong, L., U Youn, L., and Tae Soo, L.,

(2010). Antioxidant activities and tyrosinase inhibitory effects of different

extracts from Pleurotus ostreatus fruiting bodies. Mycobiology. 38(4): 295-

301. doi: 10.4489/Myco.2010.38.4.295

¯ Nusrath, Y., Rajkiran, E., Sujatha, K., and Veenavamshee, R., (2011).

Evaluation of renal protective effects of Desmodium gangeticum L .in

streptozotocin – induced diabetic rats. International journal of research in

pharmacy and chemistry.1 (2): 121-128.

¯ Nanjo, F., Goto, K., Seto, R., Suzuki, M., and Sakai, M., and Hara, Y., (1996).

Scavenging effects of tea catechins and their derivatives on 1, 1- diphenyl-2-

picryl hydrazyl radical. Free Radical Biology and Medicine. 21: 895-902.

¯ Nwanjo, H. U., Okafor, M. C., and Oze, G. O., (2006). Anti-lipid peroxidative

activity of gongronema latifolium in streptozotocin-induced diabetic rats.

Nigerian Journal of Physiological Sciences. 21 (1-2): 61-65.

¯ O’Brien, T.P., Feder, N., and Mc Cull, M.E., (1964). Polychromatic staining

of plant cell walls by toluidine blue-O. Protoplasma. 59: 364-373.

¯ Obrosova, I.G., Fathallah, L., Liu, E., and Nourooz-Zadeh, J., (2003). Early

oxidative stress in the diabetic kidney: Effect of DL alpha-lipoic acid. Free

Radical Biology and Medicine. 34: (2)186-195.

¯ Oguri, S., Motegi, K., and Endo, Y., (2003). Augmented lipopolysachride-

induction of the histamine- forming enzyme in streptozotocin – induced

diabetic mice. Biochimica et Biophysica Acta.1637 (1):83-90.

¯ Okeri, H.A., and Alonge, P.O., (2006). Determination of the ascorbic acid

content of two medicinal plants in Nigeria., Pakistan Journal of

Pharmaceutical Sciences. 19 (1): 44-48.

¯ Okwu, D.E., (2001). Evaluation of the chemical composition of indigenous

spices and flavoring agents. Global Journal of pure and Applied Sciences.

7:455–459.

¯ Ooi, V.E.C., and Liu, F., (2000). Immuno modulation and Anti-Cancer

Activity of Polysaccharide-Protein Complexes, Current Medicinal

Chemistry.7: 715-729.

¯ Osawa, T., (1994). Novel natural antioxidants for utilization in food and

biological systems. In I.Uritani, V. V. Garcia, & E. M. Mendeoza (Eds.), Post

harvest biochemistry of plant food-materials in the tropics Tokyo, Japan:

Japan Scientific Societies Press. pp.:241-251.

¯ Overton, K.H., (1963). Isolation purification and preliminary observation in

elucidation of structures by physical and chemical methods, Bently KH(Ed.),

Inter Science Pub., New York. pp: 34.

¯ Oyedemi., S.O., Adewusi, E.A., Aiyegoro, O.A., and Akinpelu, D.A., (2011).

Antidiabetic and haematological effect of aqueous extract of stem bark of

Afzelia africana (Smith) on streptozotocin-induced diabetic Wistar rats. Asian

Pacific Journal of Tropical Biomedicine.1(5): 353-358.

¯ Ozono, R., Wang, Z.Q., Moore, A.F., Inagami, T., Siragy, H.M., and Carey,

R.M., (1997). Expression of the subtype 2 angiotensin (AT2) receptor protein

in rat kidney. Hypertension. 30: 1238-1246.

¯ Pari, L., and Saravanan, G., (2002). Antidiabetic effect of Cogent db, a herbal

drug in alloxan-induced diabetes mellitus. Comparative Biochemistry and

Physiology Part C: Toxicology and Pharmacology. 131(1): 19-25.

¯ Pari, L., and Uma, M.J., (2000). Antihyperglycaemic activity of Musa

sapientum flowers: effect on lipid peroxidation in alloxan-induced diabetic

rats. Phytotherapy Research. 14 (2): 136-8.

¯ Patil, S.P., Niphadkar, P.V., and Bapat, M.M., (1997). Allergy to fenugreek

(Trigonella foenum graecum). Annals of Allergy, Asthma and Immunology.

78(3):297-300.

¯ Pavana, P., Sethupathy, S., and Manoharan, S., (2007). Antihyperglycemic

and antilipidperoxidative effects of Tephrosia purpurea seed extract in

streptozotocin induced diabetic rats. Indian Journal of Clinical Biochemistry.

22 (1): 77-83.

¯ Perrone, R.D., Madias, N.E., and Levey, A.S., (1992). Serum creatinine as an

index of renal function: new insights into old concepts.Clinical Chemistry.

38(10): 1933- 1953.

¯ Petit, P., Y. Sauvaire, G. Ponsin, M. Manteghetti and G. Ribes., (1993).Effects

of a fenugreek seed extract on feeding behavior in the rat: metabolic-endocrine

correlates. Pharmacology Biochemistry and Behavior. 45:369-374.

¯ Pietta, P., Simonetti, P., and Mauri, P., (1998). Antioxidant activity of selected

medicinal plants. Journal of Agricultural and Food Chemistry. 46: 4487-4490.

¯ Pinakini, K. S., Vasanth K., and Namita R., (2005). Evaluation of antidiabetic

activity of Ginkgo biloba in streptozotocin induced diabetic rats. Iranian

Journal of Pharmacology and Therapeutics. 4:16-19.

¯ Piraino, F., and Brandt, C.R., (1999). Isolation and partialcharacterization of

an antiviral, RC-183, from the edible mushroom Rozites caperata. Antiviral

Research. 43(2): 67-78.

¯ Powers, A.C., (2008). Diabetes Mellitus. 17th

editor. New York: McGraw Hill

Companies Inc.

¯ Prieto, P., Pineda, M., and Aguilar, M., (1999). Spectrophotometric

quantitation of antioxidant capacity through the formation of a

phosphomolybdenum complex: Specific application to the determination of

Vitamin E1. Analytical Biochemistry. 269: 337-341.

¯ Prince, P. S. M., Menon, V.P., and Pari, L., (1997). Effect of Syzigium cumini

extracts on hepatic exokinase and glucose 6-phosphatase in

experimentaldiabetes. Phytotherapy Research. 11: 529-531.

¯ Priya, D., Rajaram, K., and Suresh Kumar, P., (2011). Phytochemical studies

and GC-MS analysis of Caralluma fimbriata wall. International Journal of

Pharmaceutical Research and Development. 3(10):105-110.

¯ Pugsley, M.K., (2005). The angiotensin-II (AT-II) receptor blocker olmesartan

reduces renal damage in animal models of hypertension and diabetes.

Proceedings of the Western Pharmacology Society. 48:35–38.

¯ Raghuramulu, N., Nair, K. M., and Kalyanasundaram, S., (2003). A manual of

laboratory techniques. National Institute of Nutrition Hyderabad, Indian

council of medicinal research. pp: 57

¯ Rajarathanam, S., Sashirekha, M.N., and Bano, Z., (1992). Biopotentialities of

the basidiomycetes. Advances in Applied Microbiology .37: 233-361.

¯ Rajasekaran, S., Sivagnanam, K., and Subramanian, S., (2005). Antioxidant

effect of Aloe vera gel extract in streptozotocin-induced diabetes in rats.

Pharmacological Reports. 57(1): 90-96.

¯ Ramachandran, A., Snehalatha, C., Baskar, A.D.S., Mary, S., Kumar, C.K.,

Selvam, S.,Catherine, S., and Vijay, V., (2004).Temporal changes in

prevalence of diabetes and impaired glucose tolerance associated with lifestyle

transition occurring in the rural population in India.Diabetologia .47: 860-865.

¯ Ramachandran, A., Snehalatha, C., Kapur, A., and Vijay, V., Mohan, V., Das,

A.K., Rao P.V., Yajnik C.S., Prasanna, K.S., and Nair J.D., (2001). Diabetes

Epidemiology Study Group inIndia (DESI). High prevalence of diabetes and

impaired glucose tolerance in India: National Urban Diabetes Survey.

Diabetologia. 44: 1094-1101.

¯ Ramaya P., sudisha, J., Lakshmi Devi, N., and Aradhya, S.M., (2011).

Antibacterial and anti-oxidant activities of fenugreek Trigonella foenum

graecum L. Leaves.Research Journol of medicinal plant. 5 (6): 695-705.

¯ Ramdas, P., and Balakrishnan, S., (2012). Extract of Adenanthera pavonina L.

seed reduces development of diabetic nephropathy in streptozotocin-induced

diabetic rats. Avicenna Journal of Phytomedicine Autumn. 2(4):233-242.

¯ Rangachari, B., and Savarimuthu, I., (2011). Antidiabetic and hypolipidemic

effect of methanol extract of Lippia nodiflora L. in streptozotocin induced

diabetic rats Asian Pacific Journal of Tropical Biomedicine. S30 - S36.

¯ Raphel, K.R., Sabu, M.C., and Kuttan, R., (2002). Hypoglycaemic effect of

methanol extract of Phyllanthus amarus schum and thonn on allxan induced

diabetic mellitus in rats and its relation with antioxidant potential. Indian

Journal of Experimental Biology .40 (8): 905-909.

¯ Ravel, R.,(1984). Renal function tests.In.Clinical Application of Laboratory

Data, 4th

ed. Year Book Medicinal Pblishers Inc., New York , pp:129-140.

¯ Ravi, K., Ramachandra, B., and Subramanian, S., (2004). Protective effect of

Eugenia jambolana seed kernel on tissue antioxidants in streptozotocin

induced diabetic rats. Biological and Pharmaceutical Bulletin. 27 (8): 1212-

1217.

¯ Razali, N., Razab, R., Mat Junit, S., and Abdul Aziz, A., (2008). Radical

scavenging and reducing properties of extracts of cashew shoots (Anacardium

occidentale). Food Chemistry. 111(1): 38 – 44.

¯ Re, R., Pellegrini, N., Proteggente, A., Pannala, A., Yang, M., and Rice-

Evans, C., (1999). Antioxidant activity applying an improved ABTS radical

cation decolourization assay. Free Radical Biology and Mediicine. 26: 1231-

1237.

¯ Reena, R., and Kalidas, S., (2007). Improved α-amylase and Helicobacter

pylori inhibition by fenugreek extracts derived via solid-state bioconversion

using Rhizopus oligosporus. Asia Pacific Journal of Clinical Nutrition. 16

(3):382-392.

¯ Refaie, F.M., Esmat, A.Y., Daba, A.S., Osman, W.M., and Taha, S.M., (2010).

Hepatoprotective activity of polysaccharo-peptides from Pleurotus ostreatus

mycelium on thioacetamidein toxicated mice. Micología Aplicada

International .22: 1-13.

¯ Refaie, F.M., Esmat, A.Y., Daba, A.S., and Taha, S.M., (2009).

Characterization of polysaccharopeptides from Pleurotus ostreatus mycelium:

assessment of toxicity and immunomodulation in vivo. Micología Aplicada

International. 21: 67-75.

¯ Rerup, C.C., (1970). Drugs producing diabetes through damage of the insulin

secreting cells. Pharmacological Reviews. 22 :( 4) 485-518. PMID 4921840.

¯ Rhemann, A.U., and Zaman, K., (1989). Medicinal plants with hyperglycemic

activity. Journal of Ethnopharmacology. 26: 1-55.

¯ Robak, J., and Gryglewski R.J., (1988). Flavonoids are scavengers of

superoxide anions. Biochemical Pharmacolology. 17: 837-841.

¯ Rodríguez-Iturbe, B., Pons, H., Herrera-Acosta, J., and Johnson, R.J., (2001).

Role of immunocompetent cells in nonimmune renal diseases. Kidney

International. 59: 1626-1640.

¯ Ruiz-Ortega, M., Lorenzo, O., Rupérez, M., Esteban, V., and Mezzano, S.,

Egido, J., (2001). Renin-angiotensin system and renal damage: emerging data

on angiotensin II as a proinflammatory mediator. Contributions to

Nephrology.135: 123-137.

¯ Sadasivam, S., and Manikam, A., (2008). Biochemical methods, 3rd edition,

New age International Limited, New Delhi. pp: 193-195.

¯ Sakthisekaran, D., and Rajasekaren S., (2007). Protective role of Momordica

charantia seed extracts on Membrane bound ATPases and lysosomal

hydrolases in rats with streptozotocin diabetes. Journal of plant sciences. 2

(3): 229-301.

¯ Sandven, P., (2000). Epidemiology of canidemia. Revista Iberoamericana de

Micología.17: 73-81.

¯ Santhi, R., Lakshmi, G., Priyadharshini, A.M., and Anandaraj, L., (2011).

Phytochemical screening of Nerium oleander leaves and Momordica chrantia

leaves. International Research Journal of Pharmacy. 2: 131-135.

¯ Saritha Krishna, L., Usha, P.T.A., and Chandrasekhara Nair, A.M.,

(2009).Hypoglycaemic effect of pleurotus ostreatus in rats. Indian Journal of

Animal Research.43 (2): 139-141.

¯ Sass, J.E., (1940). Elements of botanical micro technique. McGraw Hill Book

Co; New York. pp: 222

¯ Sauvaire, Y., Ribes, G., Baccou, J.C., and Loubatieres-Mariani, M.M.,

(1991). Implication of steroid saponins and sapogenins in the

hypocholesterolemic effect of fenugreek. Lipids. 26 (3): 191-197.

¯ Savithramma, N., Linga Rao, M., and Suhrulatha, D., (2011). Screening of

medicinal plants for secondary metabolites Middle - East. Journal of Scientific

Research. 8: 579-584.

¯ Scurtichini, M., and Pia rossi , M., (1991). Preliminary invitro evaluation of

the antimicrobial activity of triterpenes and terpenoids towards Erwina

amylovora (Burrill). Journal of Applied Bacteriology. 71: 109-12.

¯ Selegean, M., Putz, M.V., and Rugea, T., (2009). Effects of the polysaccharide

extract from the edible Mushroom Pleurotus ostreatus against infectious

bursal disease virus. International Journal of Molecular Sciences. 10(8):

3616-3634.

¯ Sethi, P.D., (1996) High Performance Thin Layer Chromatography (1st

Edition). CBS Publishers and Distributors, New Delhi, pp: 1-56.

¯ Shahidi, F., Janitha, P. K., and Wanasundara, P. D., (1992). Phenolic

antioxidants. Critical Reviews in Food Science and Nutrition. 32 (1), 67–

103. . doi:10.1080/10408399209527581

¯ Shani, J., Goldschmied, A., Joseph, B., and Ahronson, Z., Sulma, F.G., (1974)

Hypoglycemic effect of Trigonella foenum graecum and Lupinus termis

(leguminosae) seeds and their major alkaloid in alloxan diabetic and normal

rats. Archives of International Pharmacodynamics and Therapeutics. 210:27-

36.

¯ Shanmugasundaram, E.R., Gopith, K.I., Radha, S.K., and Rajendram, V.M.,

(1990). Possible regeneration of the islets of Langerhans in streptozotocin

diabetic rats given Gymnema sylvestere leaf extract. Journal of

Ethnopharmacology. 30: 265-269.

¯ Sharma, R.D., (1986). Effects of fenugreek seeds and leaves on blood glucose

and serum insulin responses in human subjects. Nutrition Research.6: 1353-

64.

¯ Sharma, R.D., Raghuram, T.C., and Dayasagar Rao, V., (1991).

Hypolipidaemic effect of fenugreek seeds. A clinical study.

Phytotherapy Research. 3:145-147.

¯ Sharma, R.D., Sarkar, A., Hazra, D.K., Misra B., Singh, J. B. Maheshwari,

B.B., (1996). Toxicological evaluation of fenugreek seeds: a long term feeding

experiment in diabetic patients. Phytotherapy Research. 10:519-520.

¯ Shi, J., Arunasalam, K., Yeung, D., Kakuda, Y., Mittal, G., and Jiang, Y.,

(2004). Saponins from edible legumes: Chemistry, processing and health

benefits Journal of Medicinal Food. 7: 67-78.

¯ Shiose, A., Kuroda, J., Tsuruya, K., Hirai, M., Hirakata, H., Naito, S., Hattori,

M., Sakaki, Y., and Sumimoto, H., (2001). A novel superoxide-producing

NAD (P) Hoxidase in kidney. Journal of Biological Chemistry.276 (2): 1417–

1423.

¯ Shiota, A., Yamamoto, K., Ohishi, M., Tatara, Y., Ohnishi, M., Maekawa, Y.,

Iwamoto, Y., Takeda, M., and Rakugi, H., (2010). Loss of ACE2 accelerates

time-dependent glomerular and tubulointerstitial damage in streptozotocin-

induced diabetic mice. Hypertension Research. 33: 298-307.

¯ Shirwaikar, A., Rajendran, K., and Punitha, I.S.R., (2005.) Antidiabetic

activity of alcoholic stem extract of Coscinium fenestratum in streptozotocin-

nicotinamide induced type 2 diabetic rats. Journal of Ethnopharmacology.

97(2):369–374.

¯ Siddiqui, S., Verma, A., Rather, A.A., Jabeen, F., and Meghvansi, M.K.,

(2009). Preliminary phytochemicals analysis of some important medicinal and

aromatic plants. Advances in Biological Research. 3 (5-6):188-195.

¯ Sidhu, G.S., and Oakenfull, D.G., (1986). A mechanism for

thehypocholesterolaemic activity of saponins. British Journal of Nutrition. 55

(3):643-649.

¯ Simm, A., Münch, G., Seif, F., Schenk, O., Heidl, A., Richter, H., Vamvakas,

S., and Schinzel, R., (1997). Advanced glycation endproducts stimulate the

MAP-kinase pathway in tubulus cell line LLC-PK1. Federation of European

Biochemical Societies Letters. 410(2-3): 481–484.

¯ Singh, R., Singh, A.K., Alavi, N., and Leehey, D.J., (2003). Mechanism of

increased angiotensin II levels in glomerular mesangial cells cultured in high

glucose. Journal of the American Society of Nephrology 14 (4): 873–80.

¯ Sirag, H.M., (2009). Biochemical and hematological studies for the protective

effect of oyster mushroom (Pleurotus ostreatus) against glycerol-induced

acute renal failure in rats. Journal of Biological Sciences. 9:746-752.

¯ Sivajothi, V., Dey, A., Jayakar, B., and Rajkapoor, B., (2007).

Antihyperglycaemic property of Tragia cannabina in streptozotocin induced

diabetic rats Journal of Medicinal Food. 10: 361–365.

¯ Spurney, R.F., and Coffman, T.M., (2008). Stressed-out podocytes in

diabetes? . Journal of the American Society of Nephrology.19 (1): 2035–

2037.

¯ Stark, A., and Madar, Z., (1993). The effect of an ethanol extract derived from

fenugreek (Trigonella foenum-graecum) on bile acid absorption and

cholesterol levels in rats. British Journal of Nutrition .69:277-287.

¯ Steffes, M.W., Osterby, R., Chavers, B., and Mauer, S.M., (1989). Mesangial

expansion as a central mechanism for loss of kidney function in diabetic

patients. Diabetes. 38: 1077–1081.

¯ Subhashini, N., Thangathirupathi, A., and Lavanya, N., (2011). Antioxidant

activity of Trigonella foenum graecum using various in vitro and ex vivo

models. International Journal of Pharmacy and Pharmaceutical Sciences.

3(2): 96-102.

¯ Sun, C.P, Zhang, J.Z., and Duan, S.J. , (1999). Free radical biology Anhui

chinese science and technology university press .

¯ Sun, J.E., Ao, Z.H., Lu, Z.M., Xu, H.Y., Zhang, X.M., Dou, W.F., and Xu,

Z.H., (2008). Antihyperglycemic and antilipidperoxidative effects of dry

matter of culture broth of Inonotus obliquus in submerged culture on normal

and alloxan- diabetes mice. Journal of Ethnopharmacology. 118 (1): 7–13.

¯ Sundaram, E. N., Uma Maheswara Reddy, P., and Singh, K. P., (2009). Effect

of alcoholic extracts of Indian medicinal plants on the altered enzymatic

activities of diabetic rats.Indian Journal of Pharmaceutical Sciences. 71(5):

594–598.

¯ Surekha C.H., Kaladhar DSVGK, Raju Srikakarlapudi , J.R., and Haseena.,

(2011).Evaluation of antioxidant and antimicrobial potentiality of some edible

mushrooms.International journal of advanced Biotechnology and research.

2:(1) 130-134

¯ Susztak, K., Raff, A.C., Schiffer, M., and Bottinger, E.P., (2006). Glucose

induced reactive oxygen species cause apoptosis of podocytes and podocyte

depletion at the onset of diabetic nephropathy. Diabetes. 55 (1): 225–233.

¯ Syeda Birjees, B., Muhammad Iqbal, B., and Shahabuddin, M., (2008).

Antioxidative activity of extracts from fenugreek Seeds (Trigonella foenum-

graecum) Pakistan Journal of Analytical and Environmental Chemistry. 9

(2):78 – 83.

¯ Szkudelski, T., (2001). The mechanism of alloxan and streptozotocin action in

B cells of the rat pancreas. Physiological Research. 50 (6): 537-46.

¯ Taso , R., and Deng, Z., (2004). Separation procedures for naturally occuring

antioxidant phytochemicals. Journal of Chromatography B Analytical

Technologies in the Biomedical and Life Sciences. 812:85-99.

¯ Taura, M., Miyano, K., Minakami, R., Kamakur, S., Takeya, R., and

Sumimoto, H., (2009). A region N-terminal to the tandem SH3domain of

p47phox plays a crucial role in activation of the phagocyte NADPH oxidase.

Biochemical Journal. 419(2):329–338.

¯ Teoh, S. L., ABD Latiff, A., and Das, S., (2010). Histological changes in the

kidneys of experimental diabetic rats fed with Momordica charantia (bitter

gourd) extract. Romanian Journal of Morphology and Embryology. 51(1): 91–

95.

¯ Tesch, G.H., (2008). MCP-1/CCL2: a new diagnostic marker and therapeutic

target for progressive renal injury in diabetic nephropathy. American Journal

of Physiology - Renal Physiology. 294: F697-F701.

¯ Thallas-Bonke, V., Thorpe, S.R., Coughlan, M.T., Fukami, K., Yap, F.Y,

Sourris, K.C., Penfold, S.A., Bach, L.A., Cooper, M.E., and Forbes, J.M.,

(2008). Inhibition of NADPH oxidase prevents advanced glycation end

product-mediated damage in diabetic nephropathy through a protein kinase C-

alpha dependent pathway. Diabetes. 57 (2): 460–469.

¯ The Ayurvedic Pharmacopoeia of India, Part-I, Vol.4, (2001).The controller of

publications civil lines New Delhi, 1st ed. 3(1):33-35.

¯ Thomson, K.S., and Moland, E.S., (2000). The new b lactamases of Gram-

negative bacteria at the dawn of the new millennium. Microbes and Infection.

2: 1225-1235.

¯ Tietz, N.W., (1994).Text book of clinical chemistry, 2nd

edn, Eds. Carl A.

Burtis and Edward R. Ashwood. W.B. Saunders Company, Philadelphia,

London, Toronto, Montreal, Sydney, Tokyo. pp: 1313-1314.

¯ Tseng, A.J., (1991). Chemoprevention of tumors in MTV-H transgenic mice

with coumarins. Proceedings of the American Association for Cancer

Research. 32: A 2257.

¯ Tsuchida, K., Makita, Z., Yamagishi, S., Atsumi, T., Miyoshi, H., and Obara,

S, Ishida, M., Ishikawa, S., Yasumura, K., and Koike ,T., (1999). Suppression

of transforming growth factor beta and vascular endothelial growth factor in

diabetic nephropathy in rats by a novel advanced glycation end product

inhibitor, OPB-9195. Diabetologia. 42: 579–588.

¯ Tzianabos, A., (2000). Polysaccharide immunomodulators as therapeutic

agents: Structural aspects and biologic function Clinical Microbiology

Reviews. 13: 523-533.

¯ Varshney, I.P., and Sharma, S.C., (1966). Saponins andsapogenins: part

XXXII Trigonella foenum graecum seeds. Journal- Indian Chemical Society.

43:564-567.

¯ Velioglu, Y. S., Mazza, G., Gao, L., and Oomah, B.D., (1998). Antioxidant

activity and total phenolics in selected fruits, vegetables, and grain products.

Journal of Agricultural and Food Chemistry. 46: 4113–4117.

¯ Venkatakrishnan, V., Shenbhagaraman, R., Kaviyarasan, V., Gunasundari, D.,

Radhika, K., Dandapania, R., Loganathan, and Jagadish K., (2010).

Antioxidant and anti proliferative effect of Pleurotus ostreatus. Journal of

Phytology. 2(1): 22–28.

¯ Vyas Amit, S., Patel Nailesh, G., Panchal Aashish, H., Patel Rameshwar, K.,

and Patel Madhabhai, M., (2010). Anti -arthritic and vascular protective

effects of fenugreek, Boswellia Serrata and Acacia Catechu Alone and In

Combinations. Pharma Science Monitor. 1 (2): 95-111.

¯ Wada, T., Yokoyama, H., Matsushima, K., and Kobayashi, K., (2003).

Monocyte chemoattractant protein-1: does it play a role in diabetic

nephropathy? Nephrology Dialysis Transplantation. 18(3): 457-459.

¯ Wagner, H., and Bladt, S., (1996). Plant Drug Analysis: A Thin Layer

Chromatography Atlas. Berlin: Springer

¯ Wang, H.X., and Ng, T.B., (2001). Isolation of Pleuturegin, a novel ribosome-

inactivating protein from fresh sclerotia of the edible mushroom Pleurotus

tuber-regium. Biochemical and Biophysical Research Communications. 288:

718-721.

¯ Wasser, S.P., (2002). Medicinal mushrooms as asource of antitumor and

immune modulating polysaccharides (minireview). Applied Microbiology

and Biotechnology. 60:258-274.

¯ Wasser, S.P., and Weis, A.L., (1999a). Medicinal properties of substances

occurring in higher basidiomycetes mushrooms: Current perspectives

(Review). International Journal of Medicinal Mushrooms. 1: 31-62.

¯ Watanabe, T., (1969). Anti neoplastic activity of polysaccharides of Pleurotus

ostreatus. Nippon rinsho. Japanese journal of clinical medicine 27: 1759-

1761.

¯ Wehbi, G.J., Zimpelmann, J., Carey, R.M., and Levine, D.Z, and Burns, K.D.,

(2001). Early streptozotocin-diabetes mellitus downregulates rat kidney AT2

receptors. American Journal of Physiology - Renal Physiology. 280: F254-

F265.

¯ Weiser Frishman, M., W.H., Michaelson, D., and Abdeen, M.A., (1997). The

pharmacologic approach to the treatment of obesity. Journal of Clinical

Pharmacology. 37:453-73.

¯ Wendt, T., Tanji, N., Guo, J., Hudson, B.I., Bierhaus, A., Ramasamy, R.,

Arnold, B, Nawroth, P.P., Yan SF, D’Agati, V., and Schmidt, A.M., (2003).

Glucose, glycation, and RAGE: implications for amplification of cellular

dysfunction in diabetic nephropathy. Journal of the American Society of

Nephrology.14: 1383–1395.

¯ WHO, (1998). Quality Control Methods for Medicinal Plant Materials. World

Health Organization, Geneva.

¯ WHO. (1992) Quality control methods for medicinal plant material. Geneva:

Organisation Mondiale De La Sante; 22-34.

¯ Williams, G.H., and Dluhy, R.G., (2008). Disorders of the Adrenal Cortex.17th

editor. New York: McGraw Hill Companies Inc.

¯ Windholz, M., (1983). The Merck Index: An encyclopedia of chemicals, drugs

and biologicals10th

ed. Merck and Co., Inc., Rahway., New Jersey.

¯ Wink, D.A., Kasprzak, K.S, Maragos, C.M., Elespuri, R.K., Misra, M.,

Dunams, T.M., Cebula, T.A., Koch, W.H., Andrews, A.W., Allen, J.S., and

Keefer, L.K., (1991). DNA deaminating ability and genotoxicity of nitric

oxide and its progenitors. Science. 254 (5034): 1001-1003.

¯ Wohaieb, S.A., and Godin, D.V., (1987). Alterations in free radical tissue

defense mechanism in streptozotocin induced diabetes in rat. Diabetes. 36:

1014-1018.

¯ Wolf, G., Mueller, E., Stahl, R.A., and Ziyadeh, F.N., (1993). Angiotensin

Iiinduced hypertrophy of cultured murine proximal tubular cells is mediated

by endogenous transforming growth factor - beta. Journal of Clinical

Investigation. 92(3); 1366-1372.

¯ Wolf, G., Reinking, R., Zahner, G., Stahl, R.A., and Shankland, S.J., (2003).

Erk 1, 2 phosphorylates p27 (Kip1): Functional evidence for a role in high

glucose-induced hypertrophy of mesangial cells. Diabetologia. 46(8): 1090–

1099.

¯ Wolff, E.R.S.E., Wisbeck, M.L.L., Silveira, R.M.M., Gern Pinho, M.S.L., and

Furlan, S.A., (2008). Antimicrobial and antineoplasic activity of Pleurotus

ostreatus. Applied Biochemistry and Biotechnology. 151: 402-412.

¯ Wolff, S. P., Jiang, Z. Y., and Shunt, J. V., (1991). Protein glycation and

oxidative stress in diabetic mellitus and aging. Free Radical Biology and

Medicine. 10: 339-352.

¯ Wong, S.P., Leong L.P., and Koh, J.H.W., (2006). Antioxidant activities of

aqueous extracts of selected plants. Food Chemistry . 99 : 775-783.

¯ Yadav, A., Vallabu, S., Arora, S., Tandon, P., Slahan, D., Teichberg, S., and

Singhal, P.C., (2010). ANG II promotes autophagy in podocytes. American

journal of physiology. Cell physiology. 299: C488-C496.

¯ Yang, J.H., Lin, H.C., and Mau, J.L., (2002). Antioxidant properties of several

commercial mushrooms. Food Chemistry. 77: 229-235.

¯ Yionen, K., Saloranta, C., Kronberg, C., Leif, G., Antti, M. Suvi, and

Virtanean, M., (2003). Associations of dietary fiber with glucose metabolism

in non diabetic relatives of subjects with Type 2 diabetes. Diabetes care. 26:

1979-1985.

¯ Yokozawa, T., Chenc, P., Dong, F., Tanka, T., Nonaka, G.I., and Nishioka, I.,

(1998). Study on the inhibitory effect of tannins and flavonoids against the 1,

1 Diphenyl-2- picryl hydrazyl radical. Biochemical Pharmacology. 56: 213-

222.

¯ Yoshikawa, M., Murakami, T., Komatsu, H., and Murakami, N., Yamahara, J.,

and Matsuda, H., (1997). Medicinal food stuffs. IV. Fenugreek seed. (1):

structures of trigoneosides Ia, Ib, IIa, IIb, IIIa, and IIIb, new furostanol

saponins from the seeds of Indian Trigonella foenum-graecum L. Chemical

and Pharmaceutical Bulletin. (Tokyo). 45(1):81-87.

¯ Yu, W., Zhao, Y., and Shu, B., (2004). The radical scavenging activities of

Radix purariae isoflavanoids: A chemiluminescence study. Food chemistry.

86: 525-529.

¯ Yuan, Z.M., He, P.M., Cui, J.H., and Takeuchi, H., (1998). Hypoglycemic

effect of water-soluble polysaccharide from Auricularia auricula-judae Quel

of genetic diabetic KK-Ay mice. Bioscience, Biotechnology, and

Biochemistry. 62: 1898-1903.

¯ Zatz, R., Dunn, B.R., Meyer, T.W., Anderson, S., Rennke, H.G., Brenner,

B.M., (1986). Prevention of diabetic glomerulopathy by pharmacological

amelioration of glomerular capillary hypertension. Journal of Clinical

Investigation.77: 1925-1930.

¯ Zhang, X.Y., (2000). Principle of chemical analysis. Beijing China Science

Press, The Willians Wilking Co. Battimore. pp: 275-276.

¯ Zhernakova, A., Alizadeh, B.Z., Eerligh, P., Hanifi-Moghaddam, P., Schloot

N.C., Diosdado, B., Wijmenga, C., Roep, B.O., and Koeleman, B.P., (2006).

Genetic variants of RANTES are associated with serum RANTES level and

protection for type 1 diabetes. Genes and Immunity.7: 544-549.

¯ Zimmet, P.Z., (1992). Challenges in diabetes epidemiology - from West to the

rest. Diabetes Care. 15: 232-52.

¯ Zoja, C., Donadelli, R., Colleoni, S., Figliuzzi, M., Bonazzola, S., Morigi, M.,

and Remuzzi, G., (1998). Protein overload stimulates RANTES production by

proximal tubular cells depending on NF-kappa B activation. Kidney

International.53 (6): 1608-1615.