mrc/ucl centre for virology division of infection and immunity · 2018-04-07 · annegret pelchen...
TRANSCRIPT
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MRC/UCL Centre for Virology Division of Infection and Immunity
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What is Science?
MRC/UCL Centre for Virology Division of Infection and Immunity
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Virology
Viruses
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MRC !"#$%"&'(%&)"*+,-.&)(.",/.-%&0+%(.(12&
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Viruses
Have you had!
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Chicken Pox
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Viruses
Have you had!
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Herpes simplex
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Viruses
Have you had!
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Foot and Mouth
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Three Broken Tulips (Nicolas Robert 1624-1685) Fitzwilliam museum, Cambridge
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~10 viruses in the ocean 30
> 5,000 different viruses in 100 ml of seawater,
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40 million viruses in one cubic metre of air
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Electron Microscope
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Electron Microscope Specimen Grid, 3 mm
Annegret Pelchen Matthews MRC Laboratory for Molecular Cell Biology
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890x
Annegret Pelchen Matthews MRC Laboratory for Molecular Cell Biology
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1,200x
Annegret Pelchen Matthews MRC Laboratory for Molecular Cell Biology
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5 !m
2,900x
Annegret Pelchen Matthews MRC Laboratory for Molecular Cell Biology
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2 !m
4,800x
Annegret Pelchen Matthews MRC Laboratory for Molecular Cell Biology
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2 !m
6,800x
Annegret Pelchen Matthews MRC Laboratory for Molecular Cell Biology
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1 !m
11,000x
Annegret Pelchen Matthews MRC Laboratory for Molecular Cell Biology
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1 !m
23,000x
Annegret Pelchen Matthews MRC Laboratory for Molecular Cell Biology
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200 nm
49,000x
Annegret Pelchen Matthews MRC Laboratory for Molecular Cell Biology
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200 nm
68,000x
Annegret Pelchen Matthews MRC Laboratory for Molecular Cell Biology
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100 nm
98,000x
Annegret Pelchen Matthews MRC Laboratory for Molecular Cell Biology
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100 nm
120,000x
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100 nm
150,000x
Annegret Pelchen Matthews MRC Laboratory for Molecular Cell Biology
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100 nm
150,000x
Annegret Pelchen Matthews MRC Laboratory for Molecular Cell Biology
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FMDV
Variola
Adeno
TMV
Ebola
All images from ICTV dB at http://phene.cpmc.columbia.edu/index.htm
Mimi
Phage T4
100nm HIV
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Sneeze demo
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H N H N H N
Reassortment of Influenza
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H N H N H N
Reassortment of Influenza
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H N H N H N
H N
Reassortment of Influenza
Reassortment demo
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Virus Spread Demo
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Viruses
Have you had!
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BIOHAZARD
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Ebola
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BSL-4
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Viruses
Have you had!
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Small Pox
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Ali Maow Maalim
October 1977 the last person on Earth to catch smallpox by natural transmission.
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How do we prevent virus diseases?
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Y
Y
Y Y
Y
Y
Antibodies Killer cells
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Y Y
Y Y
Y Y
Antibodies Killer cells
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Y Y
Y Y
Y Y
Antibodies Killer cells
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Viruses are Small What about Big Pathogens?
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