mouth focus infection.pptx

8/19/2019 Mouth Focus Infection.pptx

1/15

Focus Mouth Infectionand

Focal Body Infection


2/15

Ann Periodontol. 1998 Jul;3(1):262-75.

Implications of oral infections on systemic diseases in theinstitutionalized elderly with a special focus on pneumonia.Limeb!" #.Source $!ult% o& 'entitr% *ni+erit% o& ,oronto nd.limeb!"/dentl.utoronto.!

Abstract0%temi! in&e!tion in te elderl% tient li+in in !roni! !re ettin reent ini!nt burden to te elt !re %tem. The extent to which oral organismscause systemic infections through hematogenous dissemination in theinstitutionalized elderly is still unknown. A more li"el% nd !ommon route o&%temi! in&e!tion b% orl mi!roornim i trou irtion o& oror%nel 4uid!ontinin orl toeni! mi!roornim i! !olonie te loer reirtor% tr!t

nd !ue neumoni. Respiratory pathogens emerge in the dental plaque ofelderly patients with ery poor oral hygiene and seere periodontal disease. nte !roni! !re ettin irtion o& oror%nel 4uid !ontminted it teeb!teri o!!ur in tient it diminied ot de&ene reultin in b!terilneumoni. ,i i lo roblem in inteni+e !re unit in te oitl ettin. n onetud% re-rinin it .12 !loreidine lu!onte mout ini!ntl% loeredte mortlit% rte &rom oturi!l neumoni in tient underoin oen erturer%. 0ele!ti+e dieti+e de!ontmintion te!niue in+ol+in te toi!l

li!tion o& ntimi!robil to redu!e te ri" o& !olonition o& te reirtor% tr!t been ued to redu!e te in!iden!e o& noo!omil neumoni in te !ute !re ettin o&oitl. ,i te!niue not been emlo%ed in te nurin ome ettin.


3/15

J Am 'ent Ao!. 211 Au;1>2(8):95-1>.

"uman papillomairus infections in the oral mucosa.?ut+ J 0%r@nen 0.Source 'ertment o& Brl Ptolo% nd Brl ?diolo% ntitute o& 'entitr% $!ult%o& Cedi!ine *ni+erit% o& ,ur"u $inlnd.

Abstract

#A$%&R'()*+ Publi! rene o& umn illom+iru (#PD) te !ul ent o&!er+i!l !n!er nd o& te +ilbilit% o& #PD +!!ine in!reed. A reult moretient re "in teir dentit bout orl #PD in&e!tion nd it re+ention b% men o&+!!intion. Prent o& editri! dentl tient lo m% be !on!erned en teir!ildren +e #PD-o!ited orl leion be!ue #PD in&e!tion till o&ten i !onidered urel% eull% trnmitted diee. n ti re+ie te utor ro+ide te ltetin&ormtion &or dentl ro&eionl bout #PD in&e!tion in te orl mu!o nd in

enerl. T,-S '! ST(*IS R/I0*+ ,e utor er!ed PubCed &or ll tudiererdin #PD in&e!tion in te orl mu!o nd te% re+ieed rele+nt ubli!tion&o!uin e!lui+el% on #PD in&e!tion o& te orl !+it%. n ele!tin tudie &or re+iete utor mde !ler ditin!tion beteen tudie rerdin #PD in&e!tion in temout nd toe rerdin #PD in&e!tion in te oror%n or in oter ed nd ne!"ite. RS(1TS+ #PD !n in&e!t orl mu!o. A ubrou o& orl !n!er !lerl% io!ited it #PD. Brl #PD in&e!tion i trnmitted eull% but lo !n betrnmitted &rom mout to mout nd +erti!ll% &rom n in&e!ted moter durin deli+er%.

$')$1(SI')S A)* $1I)I$A1 I2-1I$ATI')S+ Peritent #PD in&e!tion in te orlmu!o mit in!ree te ri" o& de+eloin orl !n!er. ?eulr nd meti!ulou !lini!lemintion i te dentitE mot imortnt tool in dete!tin #PD-o!ited !ne inte orl mu!oe. #PD-o!ited orl !n!er m% Fe!t oultion %ouner tn ttt%i!ll% Fe!ted b% #PD-indeendent orl !n!er. Al!ool nd tob!!o ue in!ree teri" o& de+eloin orl !n!er o ood r!ti!e in!lude en!ourin tient to +oidtee bit. ,e +ilble #PD +!!ine !o+er te #PD enot%e &ound mot !ommonl%in te orl mu!o but teir rote!ti+e eFe!t int orl !n!er remin to beelu!idted.

http://www.ncbi.nlm.nih.gov/pubmed/21804057http://www.ncbi.nlm.nih.gov/pubmed?term=Rautava%20J%5BAuthor%5D&cauthor=true&cauthor_uid=21804057http://www.ncbi.nlm.nih.gov/pubmed?term=Rautava%20J%5BAuthor%5D&cauthor=true&cauthor_uid=21804057http://www.ncbi.nlm.nih.gov/pubmed?term=Syrj%C3%A4nen%20S%5BAuthor%5D&cauthor=true&cauthor_uid=21804057http://www.ncbi.nlm.nih.gov/pubmed?term=Syrj%C3%A4nen%20S%5BAuthor%5D&cauthor=true&cauthor_uid=21804057http://www.ncbi.nlm.nih.gov/pubmed?term=Syrj%C3%A4nen%20S%5BAuthor%5D&cauthor=true&cauthor_uid=21804057http://www.ncbi.nlm.nih.gov/pubmed?term=Syrj%C3%A4nen%20S%5BAuthor%5D&cauthor=true&cauthor_uid=21804057http://www.ncbi.nlm.nih.gov/pubmed?term=Rautava%20J%5BAuthor%5D&cauthor=true&cauthor_uid=21804057http://www.ncbi.nlm.nih.gov/pubmed?term=Rautava%20J%5BAuthor%5D&cauthor=true&cauthor_uid=21804057http://www.ncbi.nlm.nih.gov/pubmed/21804057


4/15

Brl 0ur Brl Ced Brl Ptol Brl ?diol =ndod. 25 Jul;1(1):>-51.$urrent controersies in oral lichen planus+ report of an internationalconsensus meeting. -art 3. /iral infections and etiopathogenesis.Lodi G 0!ull% rroo C GriHt C 0uermn PI ,onrom .Source 'ertment o& Cedi!ine 0urer% nd 'entitr% *ni+erit% o& Ciln tl%.io+nni.lodi/unimi.it

Abstract'eite re!ent d+n!e in undertndin te immunotoenei o& orl li!en lnu(LP) te initil trier o& leion &ormtion nd te eentil toeni! t% reun"non. t i tere&ore not urriin tt te !lini!l mnement o& orl LP oe!oniderble diH!ultie to te dermtoloit nd te orl %i!in. A !onenumeetin eld in $rn!e in Cr! 23 to di!u te mot !ontro+eril e!t o&orl LP. Prt 1 o& te meetin reort &o!ue on (1) te reltioni beteen orl LP nd+irl in&e!tion it e!il emi on etiti +iru (#D) nd (2) orl LP

toenei in rti!ulr te immune me!nim reultin in l%mo!%te inltrtionnd "ertino!%te otoi. Prt 2 &o!ue on tient mnement nd tereuti!ro!e nd in!lude di!uion on mlinnt trn&ormtion o& orl LP

http://www.ncbi.nlm.nih.gov/pubmed/15953916http://www.ncbi.nlm.nih.gov/pubmed/15953916http://www.ncbi.nlm.nih.gov/pubmed/15953916http://www.ncbi.nlm.nih.gov/pubmed?term=Lodi%20G%5BAuthor%5D&cauthor=true&cauthor_uid=15953916http://www.ncbi.nlm.nih.gov/pubmed?term=Scully%20C%5BAuthor%5D&cauthor=true&cauthor_uid=15953916http://www.ncbi.nlm.nih.gov/pubmed?term=Carrozzo%20M%5BAuthor%5D&cauthor=true&cauthor_uid=15953916http://www.ncbi.nlm.nih.gov/pubmed?term=Carrozzo%20M%5BAuthor%5D&cauthor=true&cauthor_uid=15953916http://www.ncbi.nlm.nih.gov/pubmed?term=Griffiths%20M%5BAuthor%5D&cauthor=true&cauthor_uid=15953916http://www.ncbi.nlm.nih.gov/pubmed?term=Sugerman%20PB%5BAuthor%5D&cauthor=true&cauthor_uid=15953916http://www.ncbi.nlm.nih.gov/pubmed?term=Sugerman%20PB%5BAuthor%5D&cauthor=true&cauthor_uid=15953916http://www.ncbi.nlm.nih.gov/pubmed?term=Thongprasom%20K%5BAuthor%5D&cauthor=true&cauthor_uid=15953916http://www.ncbi.nlm.nih.gov/pubmed?term=Thongprasom%20K%5BAuthor%5D&cauthor=true&cauthor_uid=15953916http://www.ncbi.nlm.nih.gov/pubmed?term=Thongprasom%20K%5BAuthor%5D&cauthor=true&cauthor_uid=15953916http://www.ncbi.nlm.nih.gov/pubmed?term=Thongprasom%20K%5BAuthor%5D&cauthor=true&cauthor_uid=15953916http://www.ncbi.nlm.nih.gov/pubmed?term=Sugerman%20PB%5BAuthor%5D&cauthor=true&cauthor_uid=15953916http://www.ncbi.nlm.nih.gov/pubmed?term=Sugerman%20PB%5BAuthor%5D&cauthor=true&cauthor_uid=15953916http://www.ncbi.nlm.nih.gov/pubmed?term=Griffiths%20M%5BAuthor%5D&cauthor=true&cauthor_uid=15953916http://www.ncbi.nlm.nih.gov/pubmed?term=Carrozzo%20M%5BAuthor%5D&cauthor=true&cauthor_uid=15953916http://www.ncbi.nlm.nih.gov/pubmed?term=Carrozzo%20M%5BAuthor%5D&cauthor=true&cauthor_uid=15953916http://www.ncbi.nlm.nih.gov/pubmed?term=Scully%20C%5BAuthor%5D&cauthor=true&cauthor_uid=15953916http://www.ncbi.nlm.nih.gov/pubmed?term=Lodi%20G%5BAuthor%5D&cauthor=true&cauthor_uid=15953916http://www.ncbi.nlm.nih.gov/pubmed/15953916http://www.ncbi.nlm.nih.gov/pubmed/15953916http://www.ncbi.nlm.nih.gov/pubmed/15953916http://www.ncbi.nlm.nih.gov/pubmed/15953916http://www.ncbi.nlm.nih.gov/pubmed/15953916http://www.ncbi.nlm.nih.gov/pubmed/15953916http://www.ncbi.nlm.nih.gov/pubmed/15953916http://www.ncbi.nlm.nih.gov/pubmed/15953916http://www.ncbi.nlm.nih.gov/pubmed/15953916


5/15

J lin Ci!robiol. 1988 B!tober; 26(1): 215K219.

'ral infections and septicemia in immunocompromised patients withhematologic malignancies.B J Iermnn*ni+erit% 'ertment o& Cedi!ine nd #emtolo% Aru ount% #oitl 'enmr"

Abstract ,o etimte te role o& orl in&e!tion durin eti!emi! eiode in

immuno!omromied tient it emtoloi! mlinn!ie 78 &ebrile eiode in >6tient ere monitored it dil% !lini!l nd mi!robioloi!l in+etition. ,e 19eti!emi! eiode did not diFer &rom te 59 oter &ebrile eiode in te ulitti+e!omoition o& te erobi! nd &!ultti+el% nerobi! orl mi!ro4or or in te reen!eo& teet or !ute orl in&e!tion on d% 1. ,e orl re+len!e rte o& member o& te&mil% =nterob!teri!ee ere ier on d% 1 11 nd 12 in te &ebrile eiodeit eti!emi en !omred it toe o& &ebrile eiode itout eti!emi. The

prealence of a probable oral focus in septicemia was 34.567 and theprealence of a probable or possible oral origin in septicemia was 83.96. ,ereult uet tt re+ention nd elimintion o& orl in&e!tion m% redu!e temorbidit% nd er e+en te mortlit% in tee tient.

http://www.ncbi.nlm.nih.gov/pubmed/?term=Bergmann%20OJ%5Bauth%5Dhttp://www.ncbi.nlm.nih.gov/pubmed/?term=Bergmann%20OJ%5Bauth%5D


6/15

J Am 'ent Ao!. 26 B!t;137 0ul:210-250.

-neumonia in nonambulatory patients. The role of oral bacteria andoral hygiene.

0!nnie!o $A.Source 'ertment o& Brl Iiolo% 0!ool o& 'entl Cedi!ine *ni+erit% t IuFlo0tte *ni+erit% o& e Mor" 19 $oter #ll IuFlo .M. 1>21>. &1/buFlo.edurratum in J Am 'ent Ao!. 28 Cr;139(3):252.

Abstract#A$%&R'()*+ oniderble e+iden!e eit to uort reltioni beteen oororl elt te orl mi!ro4or nd b!teril neumoni ee!ill% +entiltor-o!ited

neumoni in intitutionlied tient. ,eet or denture +e noneddin ur&!e oni! orl biolm (tt i dentl lue) &orm tt re u!etible to !olonition b%reirtor% toen. 0ubeuent irtion o& reirtor% toen ed &rom orlbiolm into te loer ir% in!ree te ri" o& de+eloin lun in&e!tion. nddition tient m% irte in4mmtor% rodu!t &rom in4med eriodontl tiueinto te loer ir% !ontributin to lun inult. T,-S '! ST(*IS R/I0*+ ,eutor re+ieed lbortor% tudie !lini!l tril nd re+ie rti!le. $')$1(SI')S+ A

number o& tudie +e on tt te mout !n be !olonied b% reirtor% toennd er+e reer+oir &or tee ornim. Bter tudie +e demontrted tt orlinter+ention imed t !ontrollin or redu!in orl biolm !n redu!e te ri" o&neumoni in i-ri" oultion. ,"en toeter te e+iden!e i ubtntil ttimro+ed orl %iene m% re+ent neumoni in +ulnerble tient. $1I)I$A1I2-1I$ATI')S+ ntitution o& riorou orl %iene reimen &or oitlied tientnd lon-term-!re reident m% redu!e te ri" o& de+eloin neumoni.

http://www.ncbi.nlm.nih.gov/pubmed/17012732http://www.ncbi.nlm.nih.gov/pubmed?term=Scannapieco%20FA%5BAuthor%5D&cauthor=true&cauthor_uid=17012732http://www.ncbi.nlm.nih.gov/pubmed?term=Scannapieco%20FA%5BAuthor%5D&cauthor=true&cauthor_uid=17012732http://www.ncbi.nlm.nih.gov/pubmed?term=Scannapieco%20FA%5BAuthor%5D&cauthor=true&cauthor_uid=17012732http://www.ncbi.nlm.nih.gov/pubmed?term=Scannapieco%20FA%5BAuthor%5D&cauthor=true&cauthor_uid=17012732http://www.ncbi.nlm.nih.gov/pubmed/17012732


7/15

J Periodontol. 1999 Jul;7(7):793-82.

Role of oral bacteria in respiratory infection.0!nnie!o $A.Source 'ertment o& Brl Iiolo% *ni+erit% t IuFlo 0tte *ni+erit% o& e Mor"

*0A.

AbstractAn o!ition beteen orl !ondition u! eriodontl diee nd e+erlreirtor% !ondition been noted. $or emle re!ent e+iden!e ueted !entrl role &or te orl !+it% in te ro!e o& reirtor% in&e!tion. Brleriodontoti! b!teri !n be irted into te lun to !ue irtion neumoni.

,e teet m% lo er+e reer+oir &or reirtor% toen !olonition ndubeuent noo!omil neumoni. ,%i!l reirtor% toen +e been on to!olonie te dentl lue o& oitlied inteni+e !re nd nurin ome tient.Bn!e etblied in te mout tee toen m% be irted into te lun to !uein&e!tion. Bter eidemioloi! tudie +e noted reltioni beteen oor orl%iene or eriodontl bone lo nd !roni! obtru!ti+e ulmonr% diee. 0e+erlme!nim re rooed to elin te otentil role o& orl b!teri in tetoenei o& reirtor% in&e!tion: 1. irtion o& orl toen (u!

Por%romon ini+li A!tinob!illu !tinom%!etem!omitn et!.) into te lun to!ue in&e!tion; 2. eriodontl diee-o!ited en%me in li+ m% modi&% mu!olur&!e to romote deion nd !olonition b% reirtor% toen i! re tenirted into te lun; 3. eriodontl diee-o!ited en%me m% detro% li+r%elli!le on toeni! b!teri to inder teir !lern!e &rom te mu!ol ur&!e; nd>. !%to"ine oriintin &rom eriodontl tiue m% lter reirtor% eitelium toromote in&e!tion b% reirtor% toen.

http://www.ncbi.nlm.nih.gov/pubmed/10440642http://www.ncbi.nlm.nih.gov/pubmed/10440642http://www.ncbi.nlm.nih.gov/pubmed?term=Scannapieco%20FA%5BAuthor%5D&cauthor=true&cauthor_uid=10440642http://www.ncbi.nlm.nih.gov/pubmed?term=Scannapieco%20FA%5BAuthor%5D&cauthor=true&cauthor_uid=10440642http://www.ncbi.nlm.nih.gov/pubmed?term=Scannapieco%20FA%5BAuthor%5D&cauthor=true&cauthor_uid=10440642http://www.ncbi.nlm.nih.gov/pubmed?term=Scannapieco%20FA%5BAuthor%5D&cauthor=true&cauthor_uid=10440642http://www.ncbi.nlm.nih.gov/pubmed/10440642http://www.ncbi.nlm.nih.gov/pubmed/10440642http://www.ncbi.nlm.nih.gov/pubmed/10440642


8/15

J Brl Cillo&! Ptol. 211 C%-Au; 15(2): 1>>K1>7.Systemic manifestations of oral diseases itn% Ibu nd Andre Jon GomeDepartment of Oral Pathology, M.S. Ramaiah Dental College and Hospital, Bangalore,Karnataka, IndiaAddress for correspondence+Dr. Chaitanya Ba! ", Department of Oral Pathology,M.S. Ramaiah Dental College and Hospital, MSRI# Post, "e$ B%& Road, Bangalore ' ()**(+, Karnataka, India. %mail- nis/hay0/haitanya1yahoo./om

A#STRA$T ,e orl !+it% i te ite o& mu! in&e!tiou nd in4mmtor% diee i! beeno!ited it %temi! diee u! dibete !rdio+!ulr diee nd re-termlo birt. ,i rti!le emie on te orl-%temi! diee !onne!tion i! i no ridl% d+n!in re o& reer!. ,e oible %temi! diee i! rie &romorl mi!roornim re ereb% &o!ued.

%eywords+ rdio+!ulr diee dibete orl mi!roornim orl-%temi!!onne!tion re-term lo birt

http://europepmc.org/search/?scope=fulltext&page=1&query=AUTH:%22Babu%20NC%22http://europepmc.org/search/?scope=fulltext&page=1&query=AUTH:%22Babu%20NC%22http://europepmc.org/search/?scope=fulltext&page=1&query=AUTH:%22Gomes%20AJ%22mailto:[email protected]:[email protected]://europepmc.org/search/?scope=fulltext&page=1&query=AUTH:%22Gomes%20AJ%22http://europepmc.org/search/?scope=fulltext&page=1&query=AUTH:%22Babu%20NC%22http://europepmc.org/search/?scope=fulltext&page=1&query=AUTH:%22Babu%20NC%22http://europepmc.org/search/?scope=fulltext&page=1&query=AUTH:%22Babu%20NC%22http://europepmc.org/search/?scope=fulltext&page=1&query=AUTH:%22Babu%20NC%22


9/15

=ur #ert J. 1993 'e!;1> 0ul :>3-5.

#acteriology of dental infections.Ai"inen 0 Alluuu 0.Source 'ertment o& Periodontolo% *ni+erit% o& #elin"i $inlnd.

Abstract ,e mot !ommon dentl diee eriodontl diee nd dentl !rie re !roni!in&e!tion !ued b% b!teri o& norml orl 4or.


10/15

2llergy, 2sthma 3 Clini/al Imm!nology 29 5:1 doi:1.1186N171-1>92-5-1

(rticaria and infectionsIettin


11/15

=ur J ntern Ced. 21 'e!;21(6):>96-52.

*entistry and internal medicine+ from the focal infection theory tothe periodontal medicine concept.Pio G Guili ? Lo ?uo L mii G.0e!tion o& Brl 0!ien!e *ni+erit% o& Plermo Di del Dero 129 9127 Plermo tl%.

'urin t de!de te reltioni beteen dentitr% nd internl medi!ine (ee!ill%te !on!et o& te o-!lled &o!l in&e!tion teor%) +e lon been mtter o& debte.

,e toenei o& &o!l diee (mlttie) been !li!ll% ttributed to dentlul toloie nd erii!l in&e!tion. onetele in re!ent %er teir role ibein dimied (tr!urto) ile in!rein interet i bein de+oted (dedi!to) to teoible o!ition beteen eriodontl in&e!tion nd %temi! diee.n &!t periodontal pathogens and their products7 as well as in;ammatory

mediators rodu!ed in eriodontl tiue mit enter te bloodtrem (!orrentenuin) !uin %temi! eFe!t ndNor !ontributin to %temi! diee. Bn tebi o& ti me!nim !roni! eriodontiti has been suggested as a risk factorfor cardioascular diseases associated with atherosclerosis7 bacterialendocarditis7 diabetes mellitus7 respiratory disease7 preterm deliery7rheumatoid arthritis7 and7 recently7 osteoporosis7 pancreatic cancer7 metabolicsyndrome7 renal diseases and neurodegeneratie diseases such as Alzheimer


12/15

J lin Ci!robiol. 2 June; 38(6): 2317K2323.Intestinal 1esions Associated with *isseminated $andidiasis in an xperimentalAnimal 2odel

rl A. Andruti1 Perr% J. ?ile2 rol A. ummoto2 nd 0ul ,iori1O'i+iion o& n&e!tiou 'iee ,u&t *ni+erit% 0!ool o& Deterinr% Cedi!ine ortGr&ton C!uett 15361 nd 'ertment o& Cole!ulr Iiolo% nd Ci!robiolo%

,u&t *ni+erit% 0!ool o& Cedi!ine Ioton C!uett 21112

orreondin utor. Cilin ddre: 'i+iion o& n&e!tiou 'iee ,u&t *ni+erit%0!ool o& Deterinr% Cedi!ine ort Gr&ton CA 1536. Pone: (58) 839-7955. $:(58) 839-7977. =mil: 0tiori/in&onet.tu&t.edu.A#STRA$Tn umn tient dieminted !ndidii li&e-tretenin diee &orimmuno!omromied tient i o&ten o!ited it intetinl leion. n ti tud%e demontrte tt immunoureed notobioti! (GI) ilet orll% ino!ulted itild-t%e Candida ali/ansde+eloed eteni+e intetinl leion nd diemintedin&e!tion. 0e+ere ul!ertion o& te ilel mu!o ober+ed o+erl%in reion o&!olonition nd ne!roi o& te ut-o!ited l%moid tiue. 'eite te iu!etibilit% o& GI ilet to mn% mi!robil toen n +irulent mutnt trin o& C.

ali/ans &iled to rodu!e intetinl leion nd eibited oor diemintiondemontrtin tt tee eFe!t reuired +irulent ornim. t i li"el% tt in GIilet in umn tient intetinl leion ro+ide te me!nim &or e!e o& C.ali/ans &rom te trointetinl tr!t. Cultinu!leted int !ell !ontinin &unlornim ere ober+ed itin l%m node nd l%mti! +eel nd it otertoen u! !ell !ould ro+ide me!nim &or diemintion o& C. ali/ans.

http://www.ncbi.nlm.nih.gov/pubmed/?term=Andrutis%20KA%5Bauth%5Dhttp://www.ncbi.nlm.nih.gov/pubmed/?term=Riggle%20PJ%5Bauth%5Dhttp://www.ncbi.nlm.nih.gov/pubmed/?term=Kumamoto%20CA%5Bauth%5Dhttp://www.ncbi.nlm.nih.gov/pubmed/?term=Tzipori%20S%5Bauth%5Dmailto:[email protected]:[email protected]://www.ncbi.nlm.nih.gov/pubmed/?term=Tzipori%20S%5Bauth%5Dhttp://www.ncbi.nlm.nih.gov/pubmed/?term=Kumamoto%20CA%5Bauth%5Dhttp://www.ncbi.nlm.nih.gov/pubmed/?term=Riggle%20PJ%5Bauth%5Dhttp://www.ncbi.nlm.nih.gov/pubmed/?term=Andrutis%20KA%5Bauth%5D


13/15

Gut Ci!robe. 21 Jn-$eb; 1(1): >K21.Infectious diarrheaellulr nd mole!ulr me!nimim #odeQ nd ?+inder GillQ

*ni+erit% o& llinoi t i!o; 'ieti+e 'iee nd utrition; i!o L *0Aorreonden!e to: im #ode; =mil: "ode/ui!.edu N ?+inder ill; =mil:rill/ui!.edu

Abstract'irre !ued b% enteri! in&e!tion i m@or &!tor in morbidit% nd mortlit%orldide. An etimted 2K> billion eiode o& in&e!tiou dirre o!!ur e! %er ndre ee!ill% re+lent in in&nt. ,i re+ie ilit te !ellulr nd mole!ulrme!nim underl%in dirre o!ited it te tree !le o& in&e!tiou ent

i.e. b!teri +irue nd rite. 0e+erl b!teril toen +e been !oen model ornim in!ludin 4irio /holerae !li!l emle o& e!retor%dirre Clostridi!m di5/ile nd 0iell e!ie ent o& in4mmtor% dirrend ele!ted trin o& toeni! %s/heri/hia /oli (%. /oli) to di!u te re!entd+n!e in ltertion o& eitelil ion bortion. Cn% o& te re!ent tudie ddreineitelil ion trnort nd brrier &un!tion +e been !rried out uin +irue ndrite. #ere e &o!u on te ridl% de+eloin eld o& +irl dirre in!ludinrot+iru noro+iru nd tro+iru in&e!tion. $inll% e di!u 6iardia

lamlia nd %ntamoea histolyti/a emle o& riti! dirre. Prite +e reter !omleit% tn te oter toen nd re !ble o& !retin mole!uleimilr to toe rodu!ed b% te ot u! erotonin nd PG=2. ,e underl%in

me!nim o& in&e!tiou dirre di!ued in!lude ltertion in ion trnort nd tit @un!tion ell te +irulen!e &!tor i! lter tee ro!ee eiter troudire!t eFe!t or indire!tl% trou in4mmtion nd neurotrnmitter.%ey words+ in&e!tiou dirre ion bortion enteri! toen me!nim o&

dirre =P=

http://www.ncbi.nlm.nih.gov/pubmed/?term=Hodges%20K%5Bauth%5Dhttp://www.ncbi.nlm.nih.gov/pubmed/?term=Gill%20R%5Bauth%5Dhttp://www.ncbi.nlm.nih.gov/pubmed/?term=Gill%20R%5Bauth%5Dmailto:[email protected]:[email protected]:[email protected]:[email protected]://www.ncbi.nlm.nih.gov/pubmed/?term=Gill%20R%5Bauth%5Dhttp://www.ncbi.nlm.nih.gov/pubmed/?term=Gill%20R%5Bauth%5Dhttp://www.ncbi.nlm.nih.gov/pubmed/?term=Hodges%20K%5Bauth%5D


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2m 7am Physi/ian. 1998 $eb 1;57(3):>57->68.#his arti/le e8empli9es the 227P :;;


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2m 7am Physi/ian. 1998 $eb 1;57(3):>57->68.#his arti/le e8empli9es the 227P :;;

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