monthly healthcare review april 2016 - bioenterprise · pdf filecompany, ubs investment bank,...

Monthly Healthcare Review

April 2016

Company NameLast Financing

DateHQ Location Description

Last

Financing

Size

(Millions)

Lead Manager

GeNeuro (GNRO) 15-Apr-16 Geneva,

Switzerland

Developer of pharmaceutical products for disorders of the nervous system associated with

the expression of pathogenic proteins of human endogenous retroviral origin (HERV),

including the diseases multiple sclerosis and schizophrenia.

36.67 Bryan, Garnier &

Co, Societe

Generale

Aeglea BioTherapeutics

Holdings (AGLE)

7-Apr-16 Austin, TX Provider of drugs for the treatment of cancer. The company engages in clinical

development of engineered human enzymes and developing therapeutic enzymes for

oncology. Its lead drug candidate AEB1102 is being developed as an enzyme replacement

therapy in patients with the inborn error metabolism hyperargininemia that is caused by

Arginase I deficiency.

50.00 BMO Capital

Markets Corp,

Cowen and

Company, UBS

Investment Bank,

Wells Fargo

Securities

The following table includes the medical devices, biotechnology, pharmaceuticals, and healthcare IPO pricings, filings and withdrawals announced over the previous month.

IPOs

Compiled by: Morgan Reape

Sources: PitchBook, Wall Street Journal, SEC Filings, Company Press Releases, fiercebiotech.com, PE HUB, and biospace.com 1


April 2016

Company Name

Last

Financing

Date

HQ Location Round Description

Last

Financing

Size

(Millions)

Lead Investor(s)

NeuMoDx Molecular 29-Apr-16 Ann Arbor, MI Early Stage VC Provider of in-vitro molecule testing facilities in hospital and clinical

reference laboratories.

20.00 Undisclosed

Vital Metrix 28-Apr-16 Nashville, TN Angel Developer of a hemodynamic monitoring system for patient treatment.

The company provides a cardiac output measurement system which

helps to provide data to a patient's cardiologist while the patient is home

and allows for the better treatment of congestive heart failure.

0.08 Undisclosed

Synedgen 28-Apr-16 Claremont, CA Angel Developer and provider of life saving products and therapies that

encourage wound healing, reduce complications of tissue damage and

inflammation, prevent infection by drug-resistant bacteria and remove

the biofilms in which they thrive.

6.00 Andrew Miller

Sirnaomics 28-Apr-16 Gaithersburg, MD Angel Developer of novel targeted therapeutics for critical human diseases. The

company provides therapeutics to reduce scar formation and increase the

tensile strength of skin from burns, chronic skin ulcers caused by

pressure, venous stasis and diabetes mellitus.

10.00 Undisclosed

Sienna

Biopharmaceuticals

28-Apr-16 Westlake Village,

CA

Early Stage VC Developer of medical dermatology products. The company is focused on

the discovery, clinical development and commercialization of products in

aesthetics and dermatology based on scientific breakthroughs that

improves patient outcomes and physicians' practice of medicine.

34.00 ARCH Venture

Partners

NeuroChaos Solutions 27-Apr-16 Austin, TX Early Stage VC Developer and provider of products to objectively identify and monitor

Traumatic Brain Injury (TBI). The company develops products that

provide information regarding the presence of TBI, its severity and the

recovery period. Its technology can be used in emergency rooms and by

sports and military physicians, providing an objective test on which to

base clinical decisions and patient-recovery plans.

0.21 Undisclosed

Cytrellis Biosystems 27-Apr-16 Boston, MA Early Stage VC Developer of medical devices focused on dermatology, scar reduction

and aesthetic medicine.

Undisclosed Merz

Private Equity Placements and Venture Capital RoundsThe following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced

over the previous month.




April 2016

Company Name

Last

Financing

Date


Last

Financing

Size

(Millions)

Lead Investor(s)



LifeWalker 26-Apr-16 San Diego, CA Angel Manufacturer and seller of assistive mobility products for people who

need assistance with walking as a result of aging, trauma, spine or joint

replacement surgery, musculoskeletal, brain, nervous system and other

gait disorders.

Undisclosed Undisclosed

FLX Bio 26-Apr-16 South San

Francisco, CA

Early Stage VC Developer of cancer immunotherapies. The company specializes in the

research, development and commercialization of anti-cancer therapeutics

agents that combat cancer by reversing tumor immunosuppression.

50.00 The Column Group,

Topspin Partners,

Kleiner Perkins

Caufield & Byers

Dominion Aesthetic

Technologies

26-Apr-16 San Antonio, TX Angel Owner and operator of a company focused on the development of

medical devices. The company focuses on the commercialization of new

technologies in the fields of plastic and reconstructive surgeries for the

medical community.

0.20 Undisclosed

CrossBay Medical 26-Apr-16 San Rafael, CA Angel Designer, developer, manufacturer and distributer of medical devices like

gentleheels, biomatress covers and ID links for women and children.

0.01 Undisclosed

Camras Vision 26-Apr-16 Durham, NC Angel Developer of an ophthalmic medical device. The company offers

patented new technology for glaucoma patients.

1.30 Charlotte Angel

Fund, other

undisclosed

BioFactura 26-Apr-16 Frederick, MD Angel Developer of a platform for the production of biodefense drugs,

biological drugs and vaccines. The company develops biodefense drugs

against smallpox and Ebola, novel medicines for cancer, and biosimilars

for autoimmune and infectious diseases using StableFast, a

biomanufacturing platform.

1.80 Jeffrey Hausfield

Neurodyn Life Sciences 25-Apr-16 Vancouver, Canada Angel Developer of bioactives for neuroprotection and the early treatment of

neurological diseases. The company identifies bioactive compounds

within historically-proven natural treatments while validating therapeutic

candidates and also developing treatments for Parkinson’s, Alzheimer’s,

ALS and chronic nerve pain.

0.39 Undisclosed




April 2016

Company Name

Last

Financing

Date


Last

Financing

Size

(Millions)

Lead Investor(s)



Naya Health 25-Apr-16 Redwood City, CA Seed Round Developer of a breast pump technology for nursing women. Its system

fulfills the needs of working moms by providing a portable breast pump

that can be used in both the workplace and home.

4.00 Tandem Capital,

Bojiang Capital

ENT Biotech Solutions 25-Apr-16 Detroit, MI Early Stage VC Developer of medical devices for the otolaryngology market to remove

tonsils and soft tissue.

1.10 Undisclosed

Cruzar Medsystems 25-Apr-16 Braintree, MA Early Stage VC Developer of medical technology and devices. The company is designing

a catheter that allows physicians to cross obstructive lesions without

capital equipment.

0.80 Undisclosed

Augmedix 25-Apr-16 San Francisco, CA Early Stage VC Provider of a telemedicine charting service. The company caters to the

healthcare industry and offers telemedicine charting services for

documentation.

17.00 Redmile Group

Wicab 22-Apr-16 Middleton, WI Early Stage VC Operator of a biomedical engineering company. The company offers

BrainPort V100, which is a non-surgical assistive device intended for

orientation, mobility, object identification, and spot reading by

individuals who are blind with no useful vision.

2.40 Undisclosed

Trainer Rx 22-Apr-16 Walnut Creek, CA Angel Operator of a medical software company that is used for designing

solutions to meet the demands of healthcare professionals treating

musculoskeletal injury.

1.38 Undisclosed

NetMedi 22-Apr-16 Helsinki, Finland Seed Round Developer of communication software for the healthcare sector. The

company provides Kaiku, which enables secure online communication

between patients and care personnel.

0.94 Metsola Ventures

H-Source 22-Apr-16 Spokane, WA Angel Provider of an online hospital marketplace platform. The company

provides a web-based platform for hospitals to buy/sell/transfer supplies

and equipment with each other.

0.78 Undisclosed

ChartSpan Medical

Technologies

22-Apr-16 Greenville, SC Angel Provider of an online personal health record platform. The company

allows users to also carry around patient data on the mobile devices such

as X-rays and other medical images and choose whether or not to share

them.

3.20 Undisclosed




April 2016

Company Name

Last

Financing

Date


Last

Financing

Size

(Millions)

Lead Investor(s)



BioBeats 22-Apr-16 London, United

Kingdom

Early Stage VC Developer of a software combining biometric monitoring with music.

The company offers a mobile software that creates music generated from

the user’s heartbeat and helps in stress management.

2.28 White Cloud Capital

410 Medical Innovation 22-Apr-16 Durham, NC Angel Provider of a hand-operated fluid delivery device that allows medical

providers to deliver a large volume of fluid through traditional IV access

to patients during emergency situations.

0.93 Undisclosed

TripleCare 21-Apr-16 Long Island City,

NY

Early Stage VC Provider of physician services, telemedicine equipment and proprietary

software to nursing facilities. The company provides acute hospital-level

care to patients residing in nursing facilities using state-of-the-art

telemedicine technology.

2.50 Undisclosed

Silk Biomaterials 21-Apr-16 Lomazzo, Italy Early Stage VC Developer of a regenerative medical technology platform using silk. The

company is developing silk-based biomaterials designed to help

regenerate human tissues, including in the vascular system, and then to

degrade and be safely absorbed in the body.

7.78 Principia SGR

BreezoMeter 21-Apr-16 Haifa, Israel Accelerator/

Incubator

Provider of an online platform and a mobile application which allows

gathering of data from various sensors worldwide to provide a real-time,

location-based map of air pollution levels for health and wellness use.

Undisclosed Undisclosed

Rhythm Diagnostic

Systems

20-Apr-16 San Francisco, CA Angel Developer of a wearable health tracking device which can record,

measure and transmit oxygen saturation, body temperature, respiration

rate and heart rate.

4.64 Undisclosed

PeptiMimesis 20-Apr-16 Illkirch, France Seed Round Owner and operator of a biopharma company. The company offers to

develops transmembrane therapeutic peptides that enables the

identification of peptidomimetic candidates interfering with the hetero-

and/or the homodimerization of target receptors.

1.33 Alsace Capital

Medicenna Therapeutics 20-Apr-16 Vancouver, Canada Angel Operator of a clinical-stage immunotherapy research firm. The company

develops cytokines for targeted treatment of cancer, autoimmune disease

and fibrosis.

0.80 Undisclosed




April 2016

Company Name

Last

Financing

Date


Last

Financing

Size

(Millions)

Lead Investor(s)



Capture Vascular 20-Apr-16 Telluride, CO Early Stage VC Manufacturer and designer of medical devices for thrombectomy. The

company offers two products to address health issues related to coronary

artery disease, peripheral arterial disease, deep vein thrombosis and

pulmonary embolism.

2.59 Undisclosed

1Mg 20-Apr-16 New Delhi, India Early Stage VC Operator of a pharmacy discovery platform. The company provides a

portal enabling users to locate pharmaceutical providers within their local

areas. The site also provides one-click information about medicines

which have the same composition as prescribed, but which can be

cheaper.

16.00 Maverick Capital

PNA Innovations 19-Apr-16 Woburn, MA Angel Provider of customized reagents for targeting DNA and RNA. The

company develops a nucleic acid platform which is a synthetic nucleic

acid called gamma peptide nucleic acid (γPNA) for regulation of gene

expression and manipulation of nucleic acid structures and functions.

2.58 MAG Ventures

Innoblative Designs 19-Apr-16 Chicago, IL Angel Developer of a radio frequency ablation applicator. The company

develops a medical device which allows surgeons and interventionalists to

coagulate and ablate soft tissue beds intra-operatively.

1.18 Undisclosed

G-Therapeutics 19-Apr-16 Ecublens,

Switzerland

Early Stage VC Developer of an implantable neuro-stimulation system (INS). The

company provides a neuro-stimulation system to rehabilitate patients

suffering from neurological disorders such as spinal cord injury.

40.00 Life Sciences

Partners, INKEF

Capital, Gimv,

Wellington Partners

Everly Well 19-Apr-16 Austin, TX Seed Round Provider of a suite of at-home regulatory-compliant diagnostic tests that

provides results online.

2.50 Undisclosed

Eagledream Health 19-Apr-16 Rochester, NY Angel Developer of healthcare analytics software. The company develops

software that enables physicians and healthcare teams to deliver quality

care to patients, create opportunities for patient engagement and increase

efficiency and lower costs.

0.76 Undisclosed




April 2016

Company Name

Last

Financing

Date


Last

Financing

Size

(Millions)

Lead Investor(s)



Censa Pharmaceuticals 19-Apr-16 Cambridge, MA Angel Owner and operator of a pharmaceutical company. The company focuses

on the development and commercialization of therapeutics for orphan

CNS disorders.

1.51 Undisclosed

Axon Therapies 19-Apr-16 New York, NY Early Stage VC Developer of a cardiac-treatment device. The company is a developer of

a novel neuromodulation approach-based bio-electronic device to treat

heart failure.

2.00 Undisclosed

Avadyne Health 19-Apr-16 Moline, IL PE Growth/

Expansion

Provider of revenue cycle management services for the healthcare

industry. The company offers self-pay accounts receivable follow-up

services, including first-party & third-party self-pay billing services and

insurance claims resolution services, which comprise commercial

insurance follow-up, Medicare follow-up and clean-up project services.

Undisclosed MTS Health

Investors

Advantagene 19-Apr-16 Auburndale, MA Angel Operator of a biopharmaceutical company focused on oncology and

immunotherapy. The company focuses on preventing the recurrence and

progression of cancer through the use of therapeutics in oncology and

immunotherapy.

5.02 Undisclosed

Adgero

Biopharmaceuticals

19-Apr-16 Princeton, NJ Angel Developer of a photo dynamic therapy platform for the treatment of

unmet medical needs and for cutaneous metastatic breast cancer

treatment.

3.02 Undisclosed

Novarus Healthcare 18-Apr-16 Charlotte, NC Early Stage VC Developer of software for hospitals. The company develops software for

workforce management, benefits invoices management and patient

engagement.

0.75 Dioko Health

Ventures

Mediprocity 18-Apr-16 Chesterfield, MO Angel Provider of a healthcare messaging platform for doctors and patients.

The company provides an electronic patient health information platform

that protects communications among physicians, healthcare providers

and business associates.

0.18 Undisclosed

Eupraxia

Pharmaceuticals

18-Apr-16 Victoria, Canada Angel Operator of a biotechnology company. The company develops drugs

used for the treatment of arthritis and inflammatory joint diseases,

chronic pains, and diabetic macular edema and posterior uveitis.

0.04 Undisclosed




April 2016

Company Name

Last

Financing

Date


Last

Financing

Size

(Millions)

Lead Investor(s)



Colorado Therapeutics 18-Apr-16 Broomfield, CO Angel Developer of xenogenic biologic tissue matrix products and therapeutic

devices for a broad range of soft tissue reinforcement, regenerative and

vascular applications.

4.30 Undisclosed

Cearna 18-Apr-16 Chicago, IL Angel Provider of plastic surgery recovery products. The company offers a

product named OcuMend that is an ultra-penetrating nanotechnology

embeded with arnica and ledum, leading to speedy recovery of bruising,

pain and swelling caused from facial aesthetics procedures such as

rhinoplasty, blepharoplast, rhytidectomy and dermal filler.

0.66 Undisclosed

ProstaGene 17-Apr-16 Wynnewood, PA Angel Developer of a diagnostic test that distinguishes benign from malignant

prostate cancer. The company's prognostic test defines a group of

patients with poor outcome based on a signature of gene expression in

the patients prostate tumor.

0.40 Undisclosed

Fresca Medical 16-Apr-16 San Clemente, CA Angel Developer of medical devices for treatment of patients suffering from

obstructive sleep apnea diseases.

3.03 Undisclosed

SafeOp Surgical 15-Apr-16 Hunt Valley, MD Early Stage VC Manufacturer of intraoperative neuromonitoring devices that help

caregivers to monitor and prevent nerve damage that can occur during

surgical procedures.

1.75 Undisclosed

PeptiGelDesign 15-Apr-16 Cheshire, United

Kingdom

Seed Round Developer of peptide based hydrogels for biomedical and

biotechnological applications. The company develops peptide based

hydrogel, stem-cell culture and tissue engineering to support

development steps and commercialisation of therapeutic treatments from

in-vitro studies to in-vivo applications.

Undisclosed Deepbridge Capital

MatriTek 15-Apr-16 New York, NY Angel Operator of a life sciences research supply company. The company

specializes in the production of tissue-specific biomaterials that are

derived from natural organ and tissue sources and contain a wealth of

tissue‐specific biochemical factors that make up the native cellular

environment.

1.10 Undisclosed

BioCurity 15-Apr-16 New Smyrna Beach,

FL

Angel Developer of a nanoparticle drug candidate to treat radiation-related

xerostomia and dermatitis.

0.11 Undisclosed




April 2016

Company Name

Last

Financing

Date


Last

Financing

Size

(Millions)

Lead Investor(s)



Aces Health 15-Apr-16 Atlanta, GA Angel Developer of a software for patient data tracking. The company develops

a mobile and Web-based software that captures and tracks patient data

and communication essential to clinical safety and efficacy protocols.

0.08 Undisclosed

TargEDys 14-Apr-16 Rouen, France Early Stage VC Developer of a mechanism to regulate appetite. The company develops

hormone mimetic proteins which helps in regulating the eating behavior

of obese people.

6.44 Seventure Partners,

Pontifax, NCI

Reflexion Medical 14-Apr-16 Hayward, CA Early Stage VC Developer of a targeted radiation therapy system. The company is

developing a biologically-guided radiation therapy system to be used for

treating solid tumors throughout the body.

46.00 KCK Group

Quartet Health 14-Apr-16 New York, NY Early Stage VC Provider of a cloud based behavioral healthcare platform that allows

medical and behavioral health clinicians to work collaboratively on shared

treatment goals and also helps patients to access technology-enabled care.

40.00 GV

Motion Intelligence 14-Apr-16 Ithaca, NY Angel Manufacturer and developer of a medical screening device to enhance

the understanding of sports-related concussions.

3.60 Undisclosed

Imara 14-Apr-16 Cambridge, MA Early Stage VC Developer of therapeutics for diseases involving blood cells. The

company is focused on development of IMR-687, a disease-modifying

therapeutics selected for the treatment of sickle cell disease and other

hemoglobinopathies.

31.00 New Enterprise

Associates, Pfitzer

Venture

Investments,

Lundbeckfond

Eligible 14-Apr-16 Brooklyn, NY Angel Provider of a platform that streamlines insurance eligibility checks for

doctors and patients. The company offers an online platform for

healthcare eligibility queries that lets doctors process queries in real-time.

25.20 Undisclosed

Benefits Science 14-Apr-16 The Woodlands,

TX

Angel Provider of an online healthcare data analytics platform. The company

offers a Web-based platform that analyzes data from employee health-

insurance claims and predicts health risks and thereby helps them to

manage healthcare expenditures.

0.56 Undisclosed




April 2016

Company Name

Last

Financing

Date


Last

Financing

Size

(Millions)

Lead Investor(s)



Sitka Biopharma 13-Apr-16 Vancouver, Canada Seed Round Developer of a novel polymer platform technology for cancer treatment.

The company develops a polymer compound that allows taxane drugs to

adhere to the bladder wall and improves drug absorption for cancer

treatments.

Undisclosed Quark Venture

Oncorus 13-Apr-16 Cambridge, MA Early Stage VC Developer of a next-generation immunotherapy platform. The company

develops next generation oncolytic vectors for the treatment of cancer.

4.61 MPM Capital, other

undisclosed

Maize Analytics 13-Apr-16 Nashville, TN Angel Provider of machine learning software to monitor and protect patient

data. The company provides an auditing system that allows privacy

officers to identify inappropriate accesses to EMR data. The platform

uses machine learning to identify why access occurs, and then filters away

appropriate accesses, leaving a much smaller subset for manual review.

Undisclosed Jim Sohr

Keystone Mobile

Partner

13-Apr-16 Willow Grove, PA Angel Provider of shock wave lithotripsy services. The company operates

mobile units which provides a range of urological care services for

patients.

0.04 Undisclosed

CareDox 13-Apr-16 New York, NY Seed Round Provider of online health records of children to parents. The company

contacts and collects children health records from doctors and displays

data.

4.30 TEXO Ventures,

Prolog Ventures

Qu Biologics 12-Apr-16 Vancouver, Canada Angel Developer of a site specific immunotherapy. The company develops site

specific immunomodulators that stimulate activated innate immune cell

recruitment to the targeted organ or tissue to restore immune function

and treat a range of chronic diseases, including cancer and inflammatory

bowel disease.

3.02 Undisclosed

BioFluidica 12-Apr-16 Chapel Hill, NC Angel Owner and operator of a biotechnology company developing a diagnostic

platform that helps in disease management and diagnosis through

prognosis from blood samples using liquid biopsies for cancer detection.

1.08 Undisclosed




April 2016

Company Name

Last

Financing

Date


Last

Financing

Size

(Millions)

Lead Investor(s)



NurseGrid 11-Apr-16 Portland, OR Early Stage VC Developer of a mobile application for nurse scheduling in hospitals. The

company offers a suite of scheduling and staffing software that allows

nurses to communicate and share schedules with their colleagues in real-

time.

2.50 Undisclosed

MediQuire 11-Apr-16 New York, NY Early Stage VC Operator of a data analytics platform for primary care clinics. The

company offers a software which enables customers to identify clinical,

operational and financial improvement opportunities and delivers

actionable alerts to clinicians in their daily workflow.

Undisclosed FCA Ventures

Partners

Lumiata 11-Apr-16 San Mateo, CA Early Stage VC Provider of real-time medical science predictive analytics. The company

allows hospital networks, health insurance companies and risk bearing

entities to be able to continuously predict the health, risk and cost of

individuals and populations in real time and at scale. It combines big data

and data science with physician and medical science to deliver hyper-

personalized, actionable analytics.

10.00 Undisclosed

KERANOVA 11-Apr-16 Saint-Étienne,

France

Early Stage VC Designer and developer of instruments for ophthalmic surgery. The

company develops a surgical instrument to reduce the manual

intervention and provide automation in surgical procedures.

4.44 Mérieux

Développement,

CEA Investissement

InnerSpace Neuro

Solutions

11-Apr-16 Tustin, CA Angel Developer of an intracranial pressure monitoring technology system. The

company provides simultaneous ICP monitoring and CSF drainage while

eliminating leveling of a fluid-based system.

2.00 Undisclosed

AbSci 11-Apr-16 Portland, OR Early Stage VC Developer of proprietary engineered Escherichia coli (E. coli) expression

system for production of soluble recombinant monoclonal antibodies

and therapeutic proteins. The company has developed a proprietary

genetically engineered E. coli-based expression system which bypasses

inclusion body formation in the production process of proteins.

5.10 Phoenix Venture

Partners

Thrive Agrobiotics 8-Apr-16 San Francisco, CA Angel Provider of research and development services for nutritive proteins and

gut cell therapy.

6.67 Undisclosed




April 2016

Company Name

Last

Financing

Date


Last

Financing

Size

(Millions)

Lead Investor(s)



MedDay

Pharmaceuticals

8-Apr-16 Paris, France Early Stage VC Developer of novel drugs targeting brain metabolism for the treatment of

nervous system disorders.

37.78 Edmond de

Rothschild

Investment Partners

Sweetch 7-Apr-16 Jerusalem, Israel Early Stage VC Developer of a mobile application to monitor blood glucose levels. The

company offers a platform for clinical outcome prediction and wellness

prevention intervention for diabetes patients.

3.50 OurCrowd, Philips

HealthVerity 7-Apr-16 Philadelphia, PA Early Stage VC Provider of healthcare data and patient informatics. The company offers

a patient engagement platform by providing healthcare data for research

and strategy applications to healthcare stakeholders.

7.19 Flare Capital

Partners, Greycroft

Partners

Fresh Medical

Laboratories

7-Apr-16 Salt Lake City, UT Angel Owner and operator of a medical device company developing non-

invasive diagnostics. The company develops medical devices for the

purpose of lung cancer which helps to extend lives through the early risk

stratification of lung cancer.

0.52 Undisclosed

Applied BioCode 7-Apr-16 Santa Fe Springs,

CA

Angel Developer of multiplex detection systems. The company provides

Barcoded Magnetic Beads, a digital multiplexing molecular platform that

delivers multiplex analysis for molecular and protein testing needs.

9.26 Undisclosed

Thermosome 6-Apr-16 Planegg/

Martinsried,

Germany

Early Stage VC Developer of novel cancer drugs leveraging its unique platform of

thermosensitive nanocarriers to treat locally advanced solid tumors with

targeted chemotherapy. It also using a novel liposome technology based

on synthetic phospholipids that provides liposomes with prolonged

circulation half-life and ultra-fast release properties.

5.11 Bayern Kapital,

High-Tech

Gründerfonds,

other undisclosed

MedPilot 6-Apr-16 New York, NY Seed Round Provider of a healthcare software tool for patient billing and collections.

The company's software uses data science and behavioral targeting to

recommend patient engagement methods, personalize communications

and resolve outstanding balances.

0.75 Blueprint Health,

Hudson River

Capital Partners,

Tom Hirschfield




April 2016

Company Name

Last

Financing

Date


Last

Financing

Size

(Millions)

Lead Investor(s)



Jellagen 6-Apr-16 Pembroke Dock,

United Kingdom

Early Stage VC Producer of jellyfish-derived collagen for various clinical applications.

The company sources and supplies medical-grade jellyfish collagen, for

uses that include wound care and biomaterial coatings.

2.18 London Business

Angels

EnsoData 6-Apr-16 Madison, WI Seed Round Developer of software for sleep data analysis. The company develops

software which analyzes and identifies polysomnograph data and

provides auto-scoring and analytics.

0.55 Undisclosed

CoNextions Medical 6-Apr-16 Sandy, UT Angel Producer of medical devices to improve tendon repair outcomes. The

company's devices allow for faster rehabilitation, fewer complications,

and lower long-term costs.

2.50 Undisclosed

Bright Health 6-Apr-16 Minneapolis, MN Early Stage VC Provider of a health insurance service platform. The company partners

with health systems and care partners to provide health plans and a

connected healthcare experience to support relationships between

consumers and care providers.

80.00 Bessemer Venture

Partners, New

Enterprise

Associates

INanoBio 5-Apr-16 Tempe, AZ Angel Developer of a nanosensor technology. The company develops

applications in genome sequencing, healthcare diagnostics and industrial

sensing.

0.43 Undisclosed

BiOp Medical 5-Apr-16 Ramat Gan, Israel Early Stage VC Developer of an innovative real-time screening tool to identify cancerous

and pre-cancerous cells in epithelium tissues. It also enables point-of-care

diagnosis of the entire cervix, generating a real-time map of the cervix.

2.25 Shanghai Creative

Investments

Zipline 4-Apr-16 San Francisco, CA Early Stage VC Provider of drone access to healthcare. The company provides robotic

airplane service that carries vaccines, medicine, blood and medical

supplies to hospitals and health centers to help save patients' lives.

18.00 Sequoia Capital,

Google Ventures,

Standford University

Zavante Therapeutics 4-Apr-16 San Diego, CA Early Stage VC Developer of biopharmaceutical therapies to treat multi-drug resistant

bacteria. The company is developing and plans to commercialize

injectable antibiotics to combat life threatening diseases caused by drug

resistant bacteria with minimal medical options available.

45.73 Frazier Healthcare

Partners, Longitude

Capital




April 2016

Company Name

Last

Financing

Date


Last

Financing

Size

(Millions)

Lead Investor(s)



Metabomed 4-Apr-16 Yavne, Israel Early Stage VC Operator of a drug-discovery company. The company has developed a

proprietary target-identification platform for cancer that is based on

computational biology and metabolomics.

18.00 Pfizer, Arkin

Holdings, MS

Ventureson

Human Longevity 4-Apr-16 San Diego, CA Early Stage VC Provider of genomics and cell therapy-based diagnostic and therapeutic

technology. The company develops cell-based therapeutics to address age-

related decline in endogenous stem cell function. It concentrates on

cancer, diabetes and obesity, heart and liver diseases and dementia.

220.00 Illumina, Celgene

Entasis Therapeutics 4-Apr-16 Waltham, MA Early Stage VC Developer of antibacterials to treat infectious diseases caused by drug-

resistant bacteria. The company discovers and develops antibacterial

drugs to treat infections and to improve patients’ health and outcomes by

creating life-saving medicines.

50.00 Clarus

Salarius Pharmaceuticals 3-Apr-16 City of Holladay,

UT

Angel Developer of cancer therapies for pediatric, rare and other cancers. 0.78 Undisclosed

NP-C Therapeutics 1-Apr-16 King of Prussia, PA Angel Developer of a treatment therapy to treat lipid storage diseases. The

company develops a treatment therapy using a combination of three

drugs which help to treat lysosomal storage diseases.

0.18 Undisclosed

NeuroFx 1-Apr-16 Fishers, IN Seed Round Developer of adult stem cell derived technology. The company is

developing cell-free therapeutic factor concentrates derived from adult

adipose (fat) stem cells which can be used in non-neurological conditions,

such as musculoskeletal, dermatologic and cardiovascular.

1.89 Undisclosed

Müvr Labs 1-Apr-16 San Francisco, CA Accelerator/

Incubator

Provider of a wearable tracking device for physical surgery that helps

users to measure and complete their physical therapy accurately and

comprehensively. The company also offers a Web-based mobile

application to track the progress of post surgery recovery.

0.02 Y Combinator

Human Data Project 1-Apr-16 San Francisco, CA Accelerator/

Incubator

Developer of a platform that helps in matching patients to clinical trials.

The company's platform imports the medical records and medical history

of patients and searches their database to look for clinical trials with the

same medical conditions.

0.02 Y Combinator




April 2016

Company Name

Last

Financing

Date


Last

Financing

Size

(Millions)

Lead Investor(s)



DalCor 1-Apr-16 Montreal, Canada Early Stage VC Developer and provider of precision medicine to patients through

identification of patient populations, focusing on cardiovascular

medicines.

100.00 Investor Sanderling

Ventures, Andre

Desmarais

Cooper Human Systems 1-Apr-16 Nashua, NH Angel Provider of biomedical engineering services. 0.29 Undisclosed

ConnectHealth 1-Apr-16 Nairobi, Kenya Accelerator/

Incubator

Developer of a telemedicine application that connects patients to a

doctor. The company's software enables prescription and medical advice

delivery of medical consultation with doctors via a mobile device.

0.02 Y Combinator

BillionToOne 1-Apr-16 San Francisco, CA Accelerator/

Incubator

Provider of a pre-natal genetic testing device. The company specializes in

developing a non-invasive fetal genetic testing device to detect and

sequence unborn baby's DNA from mother's blood to check if the baby

has a genetic disease.

0.02 Y Combinator

BenMedica 1-Apr-16 St. Louis, MO Accelerator/

Incubator

Provider of a healthcare cost management platform. The company

enables insurers to communicate with physicians regarding patient’s drug

costs, coverage and pertinent clinical information via the existing

physician office electronic medical record.

0.10 Capital Innovators

Atrin Pharmaceuticals 1-Apr-16 Doylestown, PA Angel Developer of cancer treatment therapies. The company specializes in

developing medications and therapies for the treatment of breast,

pancreatic, lung, ovarian, and colon cancers.

1.50 Undisclosed




April 2016

Acquirer Target HQ Location Date DescriptionTransaction

Value (Millions)

Hi-Tech

Pharmaceuticals

Gaspari Nutrition Lakewood, NJ 28-Apr-16 Manufacturer and retailer of nutrition supplements for athletes. The company

produces dietary supplements for professional athletes and recreational fitness

enthusiasts to improve their performance and physique.

Undisclosed

Neogen Corporation Deoxi

Biotecnologia

Araçatuba, Brazil 27-Apr-16 Provider of molecular biology laboratory services. The company operates as a

molecular biology research firm and provides identification of deoxyribonucleic

acid (DNA) single nucleotide polymorphism (SNP) markers and submicroscopic

chromosomal alterations, using techniques for SNP chip genotyping and next

generation sequencing (NGS) services. It also provides human, animal and plant

genetics research services.

Undisclosed

Inbox Health CakeHealth San Francisco, CA 25-Apr-16 Provider of online healthcare expense-management services where users can

manage their healthcare plans, claims and bills. It also enables users to see their

out-of-pocket spending, the state of deductibles and unused benefits.

Undisclosed

Allergan Topokine Boston, MA 21-Apr-16 Developer of therapies for dermatology and medical aesthetics. The company

develops topical medications for non-invasive contouring of the face and body

and develops non-invasive therapies for subcutaneous fat disorders.

85.00

NorthEdge Capital,

Graham Ewart, Stuart

McA

Direct Healthcare

Services

Caerphilly, United

Kingdom

21-Apr-16 Manufacturer of pressure area care systems for the healthcare industry. The

company develops therapeutic support surfaces which include mattresses,

cushions and overlays and serves acute and community NHS Trusts.

Undisclosed

Stryker Becton Dickinson

& Company

(Vertebral

Augmentation

Solutions Business)

Franklin Lakes, NJ 21-Apr-16 Manufacturer of instruments for back surgery. The company develops vertebral

compression and vertebral augmentation systems used in vertebroplasty and

vertebral augmentation procedures.

Undisclosed

GI Partners, Allscripts

Healthcare

Netsmart

Technologies

Overland Park, KS 19-Apr-16 Provider of enterprise software and software services that support integrated,

coordinated delivery of health services across the spectrum of care.

950.00

Amryt Pharmaceuticals Birken (Germany) Niefern-

Öschelbronn,

Germany

19-Apr-16 Developer and manufacturer of bio-pharmaceutical and dermatology products.

The company develops and manufactures bio-pharmaceuticals, wound healing,

cosmetics and skin care products.

Undisclosed

NanoAntibiotics LAT Pharma Chicago, IL 18-Apr-16 Developer of medicine for ascites due to liver cirrhosis. Undisclosed

Mergers and AcquisitionsThe following table includes mergers and acquisitions for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous

month.




April 2016


Value (Millions)


month.

RJD Green Iosoft Tulsa, OK 18-Apr-16 Developer of medical billing software for claims adjudication, automotive

warranty payments and electronic payments between healthcare service providers

and customers.

Undisclosed

Acorda Therapeutics Biotie Therapies Turku, Finland 18-Apr-16 Provider of drug development services focused on products for

neurodegenerative and psychiatric disorders. Its products portfolio includes,

Selincro, Tozadenant (SYN115), NRL-1, Nepicastat (SYN117), BTT-1023 and

SYN120.

363.00

WuXi AppTec Co Crelux Martinsried,

Germany

15-Apr-16 Provider of drug research and discovery services. The company engages in

discovery of proteins which are used for biophysical screening and producing

protein crystals that are used in drugs.

Undisclosed

Ethicon NeuWave Medical Madison, WI 14-Apr-16 Developer of energy based invasive medical devices. The company manufactures

and markets minimally invasive soft-tissue microwave ablation systems.

Undisclosed

athenahealth Arsenal Health Watertown, MA 14-Apr-16 Developer of time-management software for healthcare professionals. The

company offers an application designed to help doctors predict patient no-shows

to allow better management of daily appointments and patient scheduling.

Undisclosed

Adamis

Pharmaceuticals

US Compounding Conway, AR 12-Apr-16 Operator of a drug compounding outsourcing facility. The company provides

bespoke medications, such as corticosteroids and hormone replacement therapies.

10.20

Predictive Therapeutics Renovo Biotech Salt Lake City, UT 12-Apr-16 Provider of stem cell research and development services. The company is focused

on the development, processing and distribution of innovative allograft tissues,

stem cells and biomaterials for the treatment of serious and debilitating diseases.

Undisclosed

Maven Capital Partners,

Patrick Sparkes

Westfield Medical Radstock, United

Kingdom

11-Apr-16 Manufacturer of one-time-use sterilization packaging products. The company's

range of products include heat seal sterilization bags, sterilization reels,

sterilization pouches and hospital sterilization packaging products.

17.08

Ossur Touch Bionics Livingston, United

Kingdom

11-Apr-16 Provider of prosthetic technologies and supporting services. The company's

products include myoelectric prosthetic hand and prosthetic finger technology, as

well as passive silicone prostheses that matches the natural appearance of the

wearer.

39.14




April 2016


Value (Millions)


month.

Aché Laboratórios

Farmacêuticos

Nortis Farmacêutica Londrina, Brazil 11-Apr-16 Manufacturer of antibiotics and non-prescription medicines. The company

specializes in the manufacture of cephalosporin antibiotics, nutraceuticals and

blister packs.

Undisclosed

Recipharm Nitin Lifesciences Karnal, India 11-Apr-16 Manufacturer of sterile injectables. The company specializes in manufacturing

liquid ampoules, liquid vials, sterile dry powder, multidose eye/ear drops and

lyophilized vials.

100.17

International Business

Machine

Truven Health

Analytics

Ann Arbor, MI 8-Apr-16 Operator of a healthcare analytics company. The company provides data, analytics

and performance benchmarking services. It serves the global healthcare industry

through utilization of its data assets and analytic technology and expertise.

2600.00

Stryker SafeWire Cooper City, FL 8-Apr-16 Provider of surgical devices. The company designs, develops and markets medical

devices to facilitate minimally invasive surgical procedures.

Undisclosed

Diversis Capital CaligorRx Secaucus, NJ 8-Apr-16 Distributor of comparator drugs, rescue medications, combination therapies,

ancillary supplies and logistical support for worldwide clinical trials.

Undisclosed

4d pharma BIOMAR Microbial

Technologies

León, Spain 8-Apr-16 Developer of new products in the pharmaceutical sector, bio-energy industry and

food production industry. The company focuses on collaborations with other

biotech and pharmaceutical companies in different therapeutic areas such as

cancer, CNS, anti-infectives and immunology.

3.33

Evonik Alkion

BioInnovations

Evry, France 8-Apr-16 Manufacturer of drugs for cancer treatments. The company's technology allows

production of complex pharmacologically active compounds which are only

present in plant species.

Undisclosed

Mach7 Technologies 3D Medical

(Medical

Technology)

Port Melbourne,

Australia

8-Apr-16 Provider of medical printing services. The company is engaged in offering medical

specific three-dimensional (3D) printing and holographic projection services.

44.90

Adavium Medical Hemogram

Industria e

Comercio

São Paulo, Brazil 7-Apr-16 Developer of lab devices for assessing and processing blood products. The

company is the developer of a haematological cell analyzer, which offers

evaluation of white and red blood cells, as well as separating constituent parts of

blood, to be processed as reagents.

Undisclosed




April 2016


Value (Millions)


month.

Lightbeam Health

Solutions

Browsersoft Shawnee, KS 6-Apr-16 Provider of a health information exchange (HIE). The company provides a system

which enables healthcare communities to exchange data from disparate systems

enabling providers to have the most comprehensive and up to date patient

information.

Undisclosed

SwervePay StatPayMD Chicago, IL 5-Apr-16 Provider of high-deductible health plans online. The company's platform allows

patients to make appointments online and provides pre-negotiated prices for the

medical procedures.

Undisclosed

Trajan Scientific LEAP Technologies

(Part of the Trajan

Family)

Carrboro, NC 5-Apr-16 Provider of automated sample preparation systems. The company offers HDX,

Benchtop NMR, dispensers, gas chromatography, pumps, research and

development, life science, pharmaceutical, polymer, food processing, forensic and

academic sectors.

Undisclosed

Strides Shasun Moberg Pharma

(Three Brands)

Bromma, Sweden 4-Apr-16 Provider of Vanquish, a pain relieving cream and tablet, and Fergon, an iron

supplement.

10.00

Citius Pharmaceuticals Leonard-Meron

Biosciences

Cranford, NJ 4-Apr-16 Provider of drug development services. The company operates as a biotechnology

company engaged in development of a antibiotic lock to treat catheter-related

bloodstream infections.

Undisclosed

Medidata Solutions Intelemage Cincinnati, OH 4-Apr-16 Developer of software products for the medical and pharmaceutical sector. The

company is engaged in the development and designing of software systems which

are utilized for image transfers and exchange activities, advanced clinical data

workflow management and electronic data capture.

Undisclosed

Positivo Informatica Hi Technologies Curitiba, Brazil 4-Apr-16 Manufacturer of health monitoring devices. The company offers biomedical

equipment, electrocardiogram machines and telemedicine technology to medical

institutions, hospitals and clinics.

Undisclosed

Segulah Hermes Medical

Solutions

Stockholm, Sweden 4-Apr-16 Provider of systems and software services for the medical industry. The company

engages in integration, visualization, processing and archiving of image data from

different modaliter and manufacturer of scanning equipment in molecular imaging

and radiology.

Undisclosed

CooperSurgical Genesis Genetics Plymouth, MI 4-Apr-16 Provider of genetic testing services. The company offers services to identify the

correct number of chromosomes and DNA that contributes to problematic health

issues.

60.00




April 2016


Value (Millions)


month.

KAI Innovations Trimara Ottawa, Canada 1-Apr-16 Developer and distributor of medical software suites. The company provides a

software which specializes in electronic medical records, network management,

desktop management, database management, disaster recovery and also offers

services such as web development and project management.

Undisclosed

American Capital

Equity, New Canaan

Funding

Science Care Phoenix, AZ 1-Apr-16 Operator of a non-transplant human tissue bank. The company offers physician

training, surgical device development, neurological research and drug discovery

services.

Undisclosed

Stryker Corporation Sage Products Cary, IL 1-Apr-16 Manufacturer of healthcare products. The company produces cosmetics, over-the-

counter drugs and pharmaceuticals.

2775.00

THERAMetrics Relief Therapeutics Genève,

Switzerland

1-Apr-16 Developer of therapies focused on unmet medical needs. The company develops

treatments that deal mainly with degeneration of the peripheral nervous system.

Undisclosed

Bristol-Myers Squibb Padlock

Therapeutics

Cambridge, MA 1-Apr-16 Provider and developer of novel drugs. This company is focused on discovering

novel therapeutics that target protein arginine deiminases an emerging class of

enzymes with roles in autoimmunity and epigenetic control.

600.00

Biotelemetry Delta Danish

Electronics, Light

and Acoustics

(ePatch Division)

Hørsholm,

Denmark

1-Apr-16 Manufacturer of cardiac monitoring devices. The company is engaged in

production and distribution of cardiac monitors utilizing proprietary patch and

sensor technology.

9.00

Gentherm Cincinnati Sub-Zero

Products

Cincinnati, OH 1-Apr-16 Manufacturer of temperature management equipment. The company is engaged in

the production and distribution of patient temperature systems for the health care

industry and custom environmental test chambers used by a wide range of

industrial manufacturing companies for product testing.

Undisclosed

Repligen Atoll Weingarten,

Germany

1-Apr-16 Manufacturer of pre-packed chromatography columns. The company specializes

in the manufacturing and distribution of MediaScout, a chromatographic column

technology platform used in the process development and clinical manufacturing

of biologic drugs.

26.11



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