Trophoblastic disease

JOURNAL READINGTrophoblastic disease

KEPANITERAAN KLINIK SENIOR DEPARTEMENT ILMU OBSTETRI DAN GINEKOLOGY RSUD DR H KUMPULAN PANE TEBING TINGGI FAKULTAS KEDOKTERAN UNIVERSITAS ISLAM SUMATERA UTARAMEDAN2015

1. IntroductionMola hidatidosa cause trofoblast and vili korealis

1.1. DefinitionsThe term gestational trophoblastic neoplasia (GTN) replaces the terms chorioadenoma destruens, metastasizing mole, and choriocarcinoma. 1.2. EtiologyOva factors : the ovum already pathologic so dead , but late is issued .Imunoselektif of trophoblast .chromosomal factor is not yet clear .insidens The reported incidence of hydatidiform mole is 1 in 125 live births in Taiwan, 2 in 1000 pregnancies in South East Asia and Japan, 1 in 1000 in Europe, and 1 in 1500 in the USA [2,3]. With complete mole, the chromosomal material from the ovum is lost and the genetic material in the conceptus is paternally derived. 2.PathologyThe histologic diagnosis of both complete and partial hydatidiform mole is well recognized.3. Required studies for patients with hydatidiform mole clinical examinationUSGNo pulses of fetalHigh serum hCG >80.000 mIU/ mL

Table 1FIGO stagedescription

IGestational trophoblastic tumors strictly confined to the uterine corpusIIGestational trophoblastic tumors extending to the adnexae or to the vagina, but limited to the genital structuresIIIGestational trophoblastic tumors extending to the lungs, with or without genital tract involvementIVAll other metastatic sitestherapyTerapi mola terdiri dari 4 tahap yaitu:1) perbaiki keadaan umum 2) pengeluaran jaringan mola (kuretase)3) terapi profilaksis dengan sitostatika (kemoterapi) 4) pemeriksaan tindak lanjut (follow up).

ConsultationPhysicians wishing for consultation concerning case management should contact their nearest Trophoblast Center early rather than late following mole evacuation.thank you