molecular genetics are we controlled by our dna ?
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Molecular Genetics Are we controlled by our DNA ?. Refer to pg 119-150 in Holtzclaw , Ch 16-21 in Campbell. Last year. What do you remember of DNA Replication and Protein Synthesis? DNA > mRNA > protein genetic info message action molecule. - PowerPoint PPT PresentationTRANSCRIPT
Molecular GeneticsAre we controlled by our Are we controlled by our DNADNA?Refer to pg 119-150 in Holtzclaw, Ch 16-21 in Campbell
Last year...Last year...What do you remember of DNA
Replication and Protein Synthesis?
DNA > mRNA > protein
genetic info message action molecule
So What?So What?Making the big connections...
◦How many cells do you have?◦Compare the DNA in each of your cells◦Compare the protein products in each
of your cells...
How does your body KNOW when to make some proteins and not others?◦THIS is gene expression
So What?So What?Model Organism: The Fruit Fly
So What?So What?More flies!
◦- Using Gene expression to study eye development
What do you think?What do you think?Are you controlled by your DNA?What are the implications of
studying Gene expression?
1) Free Write (3 min)2) Learning Walk (5 min)3) No Hands Discussion (5 min)
Review last year…Review last year…Learning Intentions!
Gene ExpressionGene ExpressionYou must know:
The functions of the three parts of an operon
The role of repressor genes in operonsThe impact of DNA methylation and
histone acetylation on gene expressionThe role of gene regulation in embryonic
development and cancer.
Gene ExpressionGene Expression
Rather important, don’t you think?:The functions of the three parts of an
operonThe role of repressor genes in operonsThe impact of DNA methylation and
histone acetylation on gene expressionThe role of gene regulation in embryonic development and cancer.
The Operon – The Operon – p. 131 in Holtz.p. 131 in Holtz.What is it?
◦Unit of genetic function◦Found in bacteria/phages/some
eukaryotes◦Consists of:
Promotor – site of RNA polymerase binding Operator – controls access of RNA
polymerase within the promotor Genes of the Operon –regulated together
by the operon
Regulatory GenesRegulatory GenesWhat do they do?
◦Produce repressor proteins that bind to the operator of an operon to block RNA polymerase from transcribing
Repressible Operon◦Usually “on,” can be inhibited...
Inducible Operon◦Usually “off,” can be induced...
The Try Operon – The Try Operon – Repressible Repressible
The Lac Operon – The Lac Operon – Inducible Inducible
Let’s make sure we get Let’s make sure we get this…this…