Compulsory coursesConcept coursesFull year courses551-0307-00 Molecular and Structural Biology I: Protein Structure and Function 3551-0307-00 Molecular and Structural Biology II: From Gene to Protein 3

Master courses (one of the three listed is compulsory; the remaining can be taken simultaneously under the category “elective compulsory” where they are listed again)

Spring semester551-1412-00 Molecular and Structural Biology IV: Visualizing Macromolecules by X-ray Crystallography and EM 4551-1414-00 Molecular and Structural Biology V: Studying Macromolecules by NMR and EPR 4551-1402-00 Molecular and Structural Biology VI: Biophysical Analysis of Macromolecules Mechanisms 4

Elective compulsory coursesConcept coursesFull year courses551-0319-00 Cellular Biochemistry (Part I)551-0320-00 Cellular Biochemistry (Part II) 6551-0313-00 Microbiology (Part I)551-0314-00 Microbiology (Part II) 6

Autumn semester529-0731-00 Nucleic Acids and Carbohydrates 6551-1295-00 Introduction to Bioinformatics: Concepts and Applications 6551-0309-00 Concepts in Modern Genetics 6

Spring semester529-0732-00 Proteins and Lipids 6551-0324-00 Systems Biology 6

Master coursesAutumn semester551-1411-00 Molecular and Structural Biology III: Current Topics 2529-0733-01 Enzymes 6551-1105-00 Glycobiology 4551-1103-00 Microbial Biochemistry (until AS 2019) 4551-1401-00 Advanced Protein Engineering 2551-1153-00 Systems Biology of Metabolism 4529-0004-01 Computer Simulation in Chemistry, Biology and Physics 6401-0649-00 Applied Statistical Regression 4401-6215-00 Using R for Data Analysis and Graphics (Part I) 1529-0041-00 Moderne Massenspektroskopie, gekoppelte Analysenmethoden, Chemometrie 6

Spring semester551-1412-00 Molecular and Structural Biology IV: Visualizing Macromolecules by X-ray Crystallography and EM 4

Prof. Eilika Weber-BanETH Zurich, Hönggerberg CampusHPK E 198093 Zurich Tel.: +41 44 633 36 78eilika.weber@mol.biol.ethz.ch

551-1103-00 Microbial Biochemistry (as of SS 2021) 4551-1414-00 Molecular and Structural Biology V: Studying Macromolecules by NMR and EPR 4551-1402-00 Molecular and Structural Biology VI: Biophysical Analysis of Macromolecules Mechanisms 4551-0224-00 Advanced Proteomics 4551-1618-00 Correlative Structural Biology with a Main Focus on Electron Microscopy 4551-0364-00 Functional Genomics 5551-1120-00 From Genetic Systems and Genomes to Systems Genetics 4551-1100-00 Infectious Agents: From Molecular Biology to Disease 4

Elective courses (free choice)Master or concept courses (from any of the nine elective majors or outside upon approval)

Elective courses in Humanities, Social or Political Sciences (min. 2 CP)

Molecular and Structural Biology

The Master programme in Molecular and Structural Biology provides a strong background in the molecular life sciences with a particular emphasis on structural and mechanistic aspects of biology. The major is anchored in the Institute for Molecular Biology & Biophysics, where research groups investigate central cellular processes such as transcription, splicing and translation as well as protein folding and degradation with a focus on the par-ticipating molecular machines. We also study membrane transport proteins and molecular assemblies involved in cell-to-cell adhesion and communication.The Master programme direction offers diverse courses: In molecular biochemistry classes, the principles of relating the functions and mechanisms of biological macromolecules with their structures are discussed. A second set of courses introduces students to modern techniques used for three-dimensional structure determi-nation of proteins and nucleic acids including X-ray crystallography, NMR spectroscopy and electron microscopy. It also organizes a course on biophysical methods that can be applied to unravel the mechanisms of biological macromolecules, including modern techniques in fluorescence and single-molecule spectroscopy. These clas-ses can be flexibly combined with courses from other majors to provide the student with a curriculum optimally tailored to his/her individual interests. Participants of the program will become experts in experimental biochemistry, which includes protein produc-tion, purification, and in vitro reconstitution of their native macromolecular assemblies. They will be trained in biochemical and biophysical characterization of these assemblies in physiologically relevant states, and will have an opportunity to employ biophysical techniques to study interactions between biological macromolecules and their ligands, as well as in three-dimensional structure determination and quantitative analysis of reaction mechanisms on the molecular level. The successful completion of the Master programme in Molecular and Structural Biology optimally prepares students for a professional career in scientific research areas concerned with biological and biomedical questi-ons on the molecular level. It provides the Master graduates with a solid scientific background for further acade-mic studies towards a PhD, but also with the skills to obtain competitive positions in biotechnology and in the chemical, biomedical and pharmaceutical industry.

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