modernize surgical pathology - 2011 genetics (molecular) functionsmorphology (physiologic or normal)
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Modernize Surgical PathologyModernize Surgical Pathology - 2011- 2011
Genetics (Molecular)Genetics (Molecular)
FunctionsFunctions
MorphologyMorphology(Physiologic or Normal)(Physiologic or Normal)
Modernize Surgical PathologyModernize Surgical Pathology - 2011- 2011
Physical injuriesPhysical injuries InfectionsInfections Immune reactionsImmune reactions
MutationMutation Epigenetic errorsEpigenetic errors
Genetics (Molecular)Genetics (Molecular)
FunctionsFunctions
MorphologyMorphology(Pathologic or Morbid)(Pathologic or Morbid)
Modernize Surgical PathologyModernize Surgical Pathology - 2011- 2011
Physical injuriesPhysical injuries InfectionsInfections Immune reactionsImmune reactions
MutationMutation Epigenetic errorsEpigenetic errors
Genetics (Molecular)Genetics (Molecular)
FunctionsFunctions
MorphologyMorphology(Pathologic or Morbid)(Pathologic or Morbid)
Modernize Surgical PathologyModernize Surgical Pathology - 2011- 2011
Physical injuriesPhysical injuries InfectionsInfections Immune reactionsImmune reactions
MutationMutation Epigenetic errorsEpigenetic errors
Genetics (Molecular)Genetics (Molecular)
FunctionsFunctions
MorphologyMorphology(Pathologic or Morbid)(Pathologic or Morbid)
EnvironmentEnvironment
Invisible causesInvisible causes Molecules (gene products)Molecules (gene products)
Functional proteins (Ab, Functional proteins (Ab, enzymes, receptors, enzymes, receptors, mediators, etc.)mediators, etc.)
Abnormal genesAbnormal genes
Visible causesVisible causes GrossGross Microscopic (light microscopy)Microscopic (light microscopy) Submicroscopic (EM)Submicroscopic (EM)
Modernize Surgical PathologyModernize Surgical Pathology - 2011- 2011
Invisible causesInvisible causes Molecules (gene products)Molecules (gene products)
Functional proteins (Ab, Functional proteins (Ab, enzymes, receptors, enzymes, receptors, mediators, etc.)mediators, etc.)
Abnormal genesAbnormal genes
Visible causesVisible causes GrossGross Microscopic (light microscopy)Microscopic (light microscopy) Submicroscopic (EM)Submicroscopic (EM)
Modernize Surgical PathologyModernize Surgical Pathology - 2011- 2011
Invisible causesInvisible causes Molecules (gene products)Molecules (gene products)
Functional proteins (Ab, Functional proteins (Ab, enzymes, receptors, enzymes, receptors, mediators, etc.)mediators, etc.)
Abnormal genesAbnormal genes
Visible causesVisible causes GrossGross Microscopic (light microscopy)Microscopic (light microscopy) Submicroscopic (EM)Submicroscopic (EM)
Modernize Surgical PathologyModernize Surgical Pathology - 2011- 2011
Invisible causesInvisible causes Molecules (gene products)Molecules (gene products)
Functional proteins (Ab, Functional proteins (Ab, enzymes, receptors, enzymes, receptors, mediators, etc.)mediators, etc.)
Abnormal genesAbnormal genes
Visible causesVisible causes GrossGross Microscopic (light microscopy)Microscopic (light microscopy) Submicroscopic (EM)Submicroscopic (EM)
Modernize Surgical PathologyModernize Surgical Pathology - 2011- 2011
Modernize Surgical PathologyModernize Surgical Pathology - 2011- 2011
Modernize Surgical PathologyModernize Surgical Pathology - 2011- 2011
Modernize Surgical PathologyModernize Surgical Pathology - 2011- 2011
1000GenomeProject: 629 1000GenomeProject: 629 people -> 7.3 TBpeople -> 7.3 TB
Cost of DNA sequencing Cost of DNA sequencing drops 50% every 5 monthdrops 50% every 5 month
Next generation Next generation sequencing-> 40Gb/daysequencing-> 40Gb/day (x4,000 !!)(x4,000 !!)
Modernize Surgical PathologyModernize Surgical Pathology - 2011- 2011
Modernize Surgical PathologyModernize Surgical Pathology - 2011- 2011
Data tsunamiData tsunamiData tsunamiData tsunamiModernize Surgical PathologyModernize Surgical Pathology - 2011- 2011
50 slides / day50 slides / day 50 GB / day50 GB / day 1.5 TB / month1.5 TB / month 18 TB / year18 TB / year
Virtual SlidesVirtual SlidesScan at x40Scan at x40
~ 1GB / slide~ 1GB / slide
Modernize Surgical PathologyModernize Surgical Pathology - 2011- 2011