ministero dell'istruzione, dell'universitÀ e della ricerca p rogetto negoziale f.i.r.b....
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MINISTERO DELL'ISTRUZIONE, DELL'UNIVERSITÀ E DELLA RICERCA
PROGETTO NEGOZIALE F.I.R.B.
Identification and functional analysis of the gene expression profiles characterizing hormone-responsive
breast cancer
AIMS:1. Identification of new panels of molecular
markers to better prognostic evaluation of breast cancer lesions, with respect to prediction of the degree of hormone responsiveness and clinical evolution of the disease;
2. Generating a publicly available list of annotations on genes and gene networks relevant to mammary gland and breast cancer biology and to ovarian hormone action;
3. Training in post-genomics and technological dissemination.
MINISTERO DELL'ISTRUZIONE, DELL'UNIVERSITÀ E DELLA RICERCA
PROGETTO NEGOZIALE F.I.R.B.
Identification and functional analysis of the gene expression profiles characterizing hormone-responsive
breast cancer
AIMS:1. Identification of new panels of molecular
markers to better prognostic evaluation of breast cancer lesions, with respect to prediction of the degree of hormone responsiveness and clinical evolution of the disease;
2. Generating a publicly available list of annotations on genes and gene networks relevant to mammary gland and breast cancer biology and to ovarian hormone action;
3. Training in post-genomics and technological dissemination.
MINISTERO DELL'ISTRUZIONE, DELL'UNIVERSITÀ E DELLA RICERCA
PROGETTO NEGOZIALE F.I.R.B.
Identification and functional analysis of the gene expression profiles characterizing hormone-responsive
breast cancer
AIMS:1. Identification of new panels of molecular
markers to better prognostic evaluation of breast cancer lesions, with respect to prediction of the degree of hormone responsiveness and clinical evolution of the disease;
2. Generating a publicly available list of annotations on genes and gene networks relevant to mammary gland and breast cancer biology and to ovarian hormone action;
3. Training in post-genomics and technological dissemination.
MINISTERO DELL'ISTRUZIONE, DELL'UNIVERSITÀ E DELLA RICERCA
PROGETTO NEGOZIALE F.I.R.B.
Identification and functional analysis of the gene expression profiles characterizing hormone-responsive
breast cancer
AIMS:1. Identification of new panels of molecular
markers to better prognostic evaluation of breast cancer lesions, with respect to prediction of the degree of hormone responsiveness and clinical evolution of the disease;
2. Generating a publicly available list of annotations on genes and gene networks relevant to mammary gland and breast cancer biology and to ovarian hormone action;
3. Training in post-genomics and technological dissemination.
Work Packages breakdown:
Workpackage 4• Activity 1-5: Cellular modelsCoordination: Second Univ. Napoli
Workpackage 2• Activity 1-4: Proteomics•Coordination: ISA-Natl Res. Council
Workpackage 3Activity 1: Animal modelsCoordination: Univ. Milano
Workpackage 4• Activity 1-3: Tumor profiling and clinical studiesCoordination: Univ. Torino
Workpackage 5• Activity 1-4: BioiformaticsCoordination: Second Univ. Napoli
Identification and functional analysis of the gene expression profiles characterizing hormone-responsive breast cancer
Clinical data
(hormone responsiveness)
Identification and functional analysis of the gene expression profiles characterizing hormone-responsive breast cancer
MOLECULAR PROFILING
gene expression profiling of tumor samples
FUNCTIONAL CHARACTERIZATION
functional genomic and proteomic analyses in experimental models
VALIDATION
‘in situ’ analyses (tissue arrays and LCM)
Identification and functional analysis of the gene expression profiles characterizing hormone-responsive breast cancer
FUNCTIONAL CHARACTERIZATION
MOLECULAR PROFILING
gene expression profiling of tumor samples
functional genomic and proteomic analyses in experimental models
‘in situ’ analyses (tissue arrays and LCM)
clinical studies
UniNa2IRCC-ToUniToIEO-MiUniFeIDI-RmUniMi (in vivo)
IST-Ge (in vivo)
ISA-CNR (proteomics)
IRCC-ToUniFeUniNa2ISA-CNR (proteomics)
UniFeIRCC-ToUniNa2
UniFeIRCC-To
BIOINFORMATICS
UniNa2 ISA-CNR IST-Ge IEO-MiUniTo IRCC-ToCINECA-Bo UniFe
VALIDATION
Identification and functional analysis of the gene expression profiles characterizing hormone-responsive breast cancer
http://www.hrbc-genomics.net/
Alessandro WeiszDipartimento di Patologia generale
Seconda Università degli Studi di Napoli