minimally invasive and hybrid coronary … · assoc. professor theo kofidis, md, pd(ger), frcs,...
TRANSCRIPT
![Page 1: MINIMALLY INVASIVE AND HYBRID CORONARY … · Assoc. Professor Theo Kofidis, MD, PD(Ger), FRCS, FAHA, FAMS Head, Dpt. Of Cardiac, Thoracic and Vascular Surgery, NUHS, Singapore MINIMALLY](https://reader030.vdocuments.mx/reader030/viewer/2022040912/5e86722996a3433fd23024d9/html5/thumbnails/1.jpg)
Assoc. Professor Theo Kofidis, MD, PD(Ger), FRCS, FAHA, FAMS
Head, Dpt. Of Cardiac, Thoracic and Vascular Surgery, NUHS,
Singapore
MINIMALLY INVASIVE AND HYBRID CORONARY
REVASCULARISATION: Tips and pitfalls
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Medtronic (Proctor / Consultant)
ABBOTT (Proctor / Consultant)
J&J (Proctor/Consultant)
LivaNova (Advisory Board)
Fehling Instruments (Proctor / Consultant)
Perfusion Services (Proctor / Consultant)
Disclosures
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Why “Minimally Invasive”?
• “He went bankrupt slowly…slowly…then suddenly”• (The so called…”Heart Team”)
• Necessity is the mother of invention: technology / disease / patients changed
• For too long: Comfort food – Comfort Surgery
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Minimally Invasive Heart Surgery
- A complete and structured Program
MICS heart tumor removal Single Incision Minimally Invasive Cardiac Surgery (SIMICS) – developed at NUHCS
One-stop Hybrid CABG
procedure
3D Minimally Inv. Heart Surgery Hybrid CABG procedureMini-AVR
(mini-thoracotomy)
Mini-Tricuspid Valve Surgery, w/o heart arrestMini-Mitral Valve
SurgeryMcGinn full CABG
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Off-pump CABG
• Less inflammation caused without
CPB
• Physiological blood flow pattern
and better perfusion of crucial
organs such as the brain and the
kidneys
• No aortic clamping required
• more technically demanding
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Off-Pump Coronary Artery Bypass (OPCAB) With experience OPCAB can be performed safely in the vast majority of cases
(>90%).
Special instruments used in OPCAB
Intraoperative illustration
Vein harvesting
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8
OPCAB: a minimalistic approach
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MIDCABG anf MVST
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MIDCAB
• Access through a small
left anterior thoracotomy
• Arterial grafting of the LITA to the LAD, multivessel approaches to CX (and RCA) possible
• No heart-lung machine required and no aortic clamping
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Operational setup
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ONLINE LEARNING
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OUR PRACTICE at NUHCS:
- Anterolateral Mini-Thoracotomy
- Direct vision IMA takedown
- Off Pump and CPB supported Beating heart (depending on
case)
- Arterial and Saphenous Grafts
- Double-Lumen tube and Single Lung ventilation
- Milrinone at the right moment
- Full Heparinisation
- Intercostal Analgesic (OnQ-Pump) for 24-48 hours
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C-Arm
AU Machine
Echo Machine
Main Trolley
S2 S3 Nurse 1
S1
Suction
Machine
Diathermy
Heart-Lung Machine
Perfusionist
A2
A1
OR Lay Out For MIS CABG Cases
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Rultract Skyhook surgical retractor system
• Attach to table on the right side of the table
• Place at right shoulder level of patient
• Adjust the attachment while harvesting the distal part of IMA
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Harvesting LIMA
Proximal end of IMA Distal end of IMA
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Thoratract Retractor
• Rail clamp
• Long and short mounting rail
• Retractor Tack
• Blades
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Mounting Rail
• Long Mounting Rail on Right side of patient - Mid thigh level - for Starfish NS
• Short mounting rail left side of patient -Abdominal level - for Octopus Nuvo
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Positioning of Positioner and stabilizer
Starfish® NS Heart Positioner
Octopus® Nuvo Tissue Stabilizer
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MIS Instruments
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TOOLS
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Minimally Invasive Direct Coronary Artery Bypass Surgery (MIDCAB)
ALEXIS SOFT TISSUE RETRACTOR –
APPLIED MEDICAL
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Harvesting of LIMA through Left Thoracotomy Approach
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Exposure of Ascending Aorta and Right Atrial Appendage
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The Intraop Setup
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OUR SETUP for MIDCABG / MVST and HYBRID
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OUR SETUP for MIDCABG / MVST and HYBRID
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Our setup for MIDCABG
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Bailout: MICS CABG with Cardioplegia
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RESULTSPostoperative lactate level
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Results – Postoperative Lactate Level
• The average postoperative serum lactate level in all the patients was 3.18 (range: 0.50—15.60)
3.35±2.35
2.24±1.36
-0.5
0.5
1.5
2.5
3.5
Mean P
osto
pe
rative S
eru
m
Lacta
te L
evel (m
mol/L)
Type of CABG
Open MICS
▪ Exploratory analysis suggested that patients who underwent MICS CABG had a significantly lower average postoperative lactate level as compared with those who underwent open CABG
▪ Mean±SD: 2.24±1.36 mmol/L vs 3.35±2.35 mmol/L)
▪ Confirmatory analysis showed that patients who were operated with MICS had a significantly lower postoperative lactate level
▪ Coefficient: -1.10 mmol/L; 95% C.I.: -1.82—-0.39, p-value: 0.002
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Results – Incidence of Complications
• A unit increase in the level of lactate could be associated with a 12% increase in the occurrence of new arrhythmia as demonstrated by the odds ratio, although the result was non-significant
• Adjusted odds ratio: 1.12
• 95% C.I.: 1.00—1.26
• p-value: 0.059
Unit Increase
Po
sto
pe
rative
La
cta
te
Incid
en
ce
of N
ew
Arr
hyth
mia
s
12%
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THORACAB
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Internal Mammary Artery Anastomosis and The Proximal Anastomosis
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Off-Pump Coronary Artery Bypass Grafting Through Left Antero-Lateral Thoracotomy (Thora-CAB)
Advantage of ThoraCAB:
•Low Incidence of Haemodyanic Instability – less manipulation of heart
•Minimal Pain – Intercostal Cryothermy
•Low Incidence of A-Fib
•Faster Convalescence
•Fewer Restriction – No Driving Restriction
•Reduce Blood Requirements
•Avoidance of Mediastinitis & Sternal Dehiscence
•Improve Cosmetic Outcome
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Off-Pump Coronary Artery Bypass Grafting Through Left Antero-Lateral Thoracotomy (Thora-CAB)
Absolute Contra-Indication:
•Emergency Surgery
•Haemodynamic Instability
•Extremely Obese Patients
•Severe Pectus Excavatus
•Severe Pulmonary Disease
Relative Contra-Indication
•Ejection Fraction <20%
•Severe Peripheral Vascular Disease – Femoral and/or subclavian / Absent of Femoral Pulse Bilaterally
•Severe LVH with Depressed LVEF OR Dilated Cardiomyopathy who require grafts to all three Coronary Arteries
•Haemodialysis – Using Left Sided AV Fistula
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HYBRID CABG
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Hybrid Coronary Revascularization
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COST
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Patient Satisfaction
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Time back to work
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Inflammatory and Hypercoagulability parameters
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Patency
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Clinical Scenarios
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CASE SCENARIO 1 – THE STRAIGHT FORWARD CASE (S)
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Marathon Runner / Patient
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MICS (McGinn) and Hybrid CABG
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65 year old diver…
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MIDCABG love
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Clinical Scenario 2
• 70 years old Indian male
• History of hypertension and dyslipidemia
• Diagnosed with triple vessel disease and planned for minimally invasive CABG
• 2D Echo: EF 40-45%, no significant valvular disease
• Weight: 57.8Kg, Height: 162cm, BMI: 22
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Coronary angiogram
RAO view of left system LAO view of left system
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Coronary angiogram
RCA: small Retrograde filling of PDA from left
system
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CXR
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CT scan (sagittal view) – diffuse ascending aortic calcification
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Case Scenario 3
• 62 year old Indian male
• Diabetes, heavy smoker, COPD (moderately severe)
• Peripheral Vascular Disease (non – occlusive)
• TVD, presented with ACS, discharged and rehospitalised with unstable angina.
• TVD, only proximal LAD (+Intermedius) flow-limiting disease, otherwise diffuse distal disease. Sent by Cardiologist for MIDCAB.
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Preop Angiography
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Preop Angiography
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Hybrid Revascularisation Case Study
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Case Summary• 69 / Chinese / Gentleman
• Past Medical History• Diabetes mellitus• Hyperlipidemia
• Presented with CCS class 2 angina
• Coronary angiogram done: Triple vessel disease• oLAD 80%• pCx 70%• RCA – long segments proximal to mid and distal stenosis of 80%
• TTE showed preserved LVEF of 60%
• U/S carotids normal
• CT thorax normal
• Hybrid Revascularisation strategy was adopted
• Planned for MIDCAB (LIMA-LAD) followed by intraoperative coronary angiogram with percutaneous coronary intervention to LCx and RCA stenoses
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Pre-op Coronary Angiogram
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LCx
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LAD
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RCA
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Intra-Op Coronary Angiogram
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LIMA-LAD Graft
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FFR - LCx
5 Fr EBU 3.5 guide catheter, PressureWire X.
Baseline Pd/Pa 81/80=1.01.
Following IC GTN 200 mcg & IV adenosine @
140 ug/kg/min, taking weight of 60 kg,
FFR=0.97.
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FFR - RCA
6 Fr JR4 guide catheter, PressureWire X.
Baseline Pd/Pa 78/81=0.97.
Following IC GTN 200 mcg & IV
adenosine @ 140 ug/kg/min, FFR=0.92.
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Progress
• Successfully underwent MIDCAB LIMA-LAD via left anterior mini-thoracotomy
• Intra-operative findings• Coronary angiogram confirmed good flow and distal runoff in LIMA-LAD graft• Functional evaluation of LCx and RCA stenoses performed
• LCx FFR: 0.97
• RCA FFR: 0.92
• No PCI was performed for stenoses of LCx and RCA which were functionally not significant
• Fit for discharge on 4th post-operative day
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MY MANTRA IN MICS SURGERY
- The Good Surgeon Knows HOW to operate
- The Very Good Surgeon knows WHEN to operate
- The Excellent Surgeon knows WHEN NOT to operate
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VDOs,
Bundled payments and
the ….cost factor
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Length of Stay
Mitral Valve MIS Median Open Median p value
Total Stay 9.2+/- 4.8 days 7 days 14.4 +/- 7.1 days 12 days < 0.001
ICU/HD 3.5 /- 2.2 days 2 days 5.3 +/- 2.8 days 5 days 0.001
GW 6.9 +/- 3.7 days 5 days 10.1 +/- 6.5 days 8 days 0.005
Aortic Valve MIS Median Open Median p value
Total Stay 7.3 +/- 2.9 days 7 days 9.8 +/- 3.5 days 10 days 0.021
ICU/HD 2.6 /- 0.8 days 2 days 3.2 +/- 1.3 days 3 days 0.099
GW 5.6 +/- 2.8 days
5 days 7.6 +/- 2.9 days 7 days 0.033
CABG MIS Median Open Median p value
Total Stay 7.0 +/- 7.5 days 5 days 10.4 +/- 14.0 days
6 days 0.100
ICU/HD 2.6 /- 1.1 days 2 days 4.1 +/- 5.1 days 3 days 0.005
GW 5.4 +/- 7.3 days 4 days 7.4 +/- 12.3 days 5 days 0.208
Mitral
Aortic
CABG
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PATIENT’S BILL
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MVR Costs
P rivate
S ubs idis ed
PRIVATE Open MIS p-value
Total Bill $65.6k +/-
$43.3k
$44.1k +/-
$27.3k
0.238
Patient’s Bill $28.3k +/-
$13.1k
$19.7k +/-
$23.3k
0.642
SUBSIDISED Open MIS p-value
Total Bill $13.6k +/- $8.0k $11.2k +/- $7.8k 0.253
Patient’s Bill $2.7 +/- $5.4k $1.5k +/- $1.7k 0.493
Overall MIS Open p-value
Total Bill
$20.6k +/-$21.7k
$21.0k +/-$24.6k
0.937
Patient’s Bill
$8.2k +/-$16.3k
$9.1k +/-$13.7k
0.895
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CABG Costs
Private
Subsidised
SUBSIDISED Open MIS p-value
Total Bill $9.3k +/- $6.6k $11.5k +/- $5.3k 0.176
Patient’s Bill $103 +/- $230 $503 +/- $1.5k 0.161
PRIVATE Open MIS p-value
Total Bill $30.8k +/- $6.9k $32.7k +/- $8.8k 0.621
Patient’s Bill $12.4k +/-
$15.0k
$13.7k +/-
$15.5k
0.865
Overall MIS Open p-value
Total Bill
$16.4k +/-$11.0k
$14.3k +/-$11.5k
0.416
Patient’s Bill
$3.5k +/-$9.5k
$2.9k +/-$8.6k
0.770
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Subsidised vs Private: MICS = 28-48%vs. Median Sternotomy: 11-15%
Private40%
Subsidized60%
Private
Subsidized
Pte48%Sub
52%
Aortic Valve
Pte45%
Sub55%
Mitral Valve
Pte28%
Sub72%
CABG
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The Heart Team - Euphemism
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The Heart Team (MDT) in 2017
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When I don’t go MICS
1. Very flat-chested pts with verticalized hearts
2. Very pycnic habitus with severe obesity and high
standing diaphragms
3. Extremely low EF
4. Severely impaired RV function
5. Very severe PHT (>90 mmHg)
6. Inaccessible, combined pathology
7. Severely calcified aorta
8. Severe adhesions
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Basic Principles of Surgery from the side
1. Don’t be fanatic about it
2. Don’t drive a Ferrari next day you get your
drivers license; Start simple: easy cases first
3. MICS Heart Surgery is …Heart Surgery first
4. Consider cost
5. Train your team
6. Individualize approach and access
7. Don’t compromise the quality of repair for the
fancy of MICS
8. Avoid extreme Anatomy, very flat-chested tiny
patients
9. Don’t turn Minimal into Maximal
10.Take good informed consent
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The NO-MICS surgeons: why?
- You don’t want to start due to age? Fear of
failure? Scrutiny by the Colleagues?
Struggle? Cost? Weak team? Too small
exposure and volume to sustain program?
Entropy?
- Have you ever tried and reversed to
classical Cardiac Surgery and why?
- Too much headaches? Effort? Bad
outcomes?
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The Li-bra: MDT in 2036
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Prominent Tip :Training and Simulation
CoE in MICS and HybridASTC
Sim Center
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MICS Simulation Centre
MICS Masstricht MV simulator
Beating Heart simulator
MICS Thorax
TEVAR Simulator
Storage
Audio/Visual
Screen
Discussion Table
Legend:
Heart Case
VATS Trainer
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https://www.youtube.com/watch?v=saGGNLbU4tI
MICS MVR Simulation
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The Medtronic MICS CABG simulators
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The Chamberlain Torsos and Simulators
https://www.thecgroup.com
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Beating Heart CABG simulators
http://www.interniche.org/en/alternatives/beat-s1-beating-heart-
simulator-opcab-training
The Beat S1 – made in Japan
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Endoscopic Vein Harvest Simulator (Macquet)
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VATS SIMULATION
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TEVAR/TAVI Simulation
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- We are Asia’s only program that is coupled with a fully equipped and relevant wet-, as well as
small- and large animal laboratory, which develops groundbreaking technology.
Hybrid Animal Lab
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CVTS
LABORATORY
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A superb the Research team
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Paco de Lucia
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