mifepristone abortion in your office · cost - $270.00 / package . brief history of mifepristone...
TRANSCRIPT
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Mifepristone Abortion
in Your Office:What you need to know
Dr. Lianne Yoshida MD, CCFP, FCFP
Medical Co-Director Nova Scotia Women’s Choice Clinic
Dalhousie Refresher March 7, 2019
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Conflict of Interest none
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Off Label Use I will mention evidence based off label use of a
medication
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Learning Objectives• Review recent changes to abortion access in Nova
Scotia
• Discuss medical abortion with Mifegymiso
Brief history
Mechanism of action
Prescribing protocols
Barriers to provision of medical abortion
• Discuss resources and support
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Abortion Access in NS As of February 5, 2018 patients can call our clinic
directly to book an appointment or get information
about abortion services in all of Nova Scotia
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New Name
TPU
NSWCC
(Nova Scotia Women’s
Choice Clinic)
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WCC Toll Free Number
1-833-352-0719
Monday – Friday 8am – 3pm
Can leave confidential message and be called back with 24 hours
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Toll Free Number Patients will talk to a clerk or RN to discuss options:
• Options counseling
• Social work support
• Information about surgical or medical abortion
• Surgical abortion appointment
• Medical abortion referral
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Surgical Abortion No change from previous service
• up to 16 weeks gestational age
• procedure under conscious sedation
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Medical Abortion• Available at the NS Women’s Choice Clinic since June
2018
• Process explained to patient, more information on NS
Women’s Choice website
• http://www.nshealth.ca/abortion
• Patients are given name of a doctor who is currently
performing medical abortions
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Nova Scotia - Mifegymiso Providers Network
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Medical Abortion with
Mifegymiso
Overview and
history
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MIFEGYMISO Canadian Trade Name
Use up to 63 days gestation age (9 weeks)
One package with two boxes
Mifepristone 200mg (Green Box)
Misoprostol 800μg - 4 x 200μg (Orange Box)
Authorized in July 2015
Cost - $270.00 / package
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Brief History of Mifepristone (RU486)
• 1970s – investigation of drugs to block the action of cortisol
• Some compounds found to block progesterone
• 1980s – RU-38486, the 38,486th compound synthesized by Roussel-Uclaf, developed and tested for abortion
• Approved in France 1988
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Brief History of Mifepristone (RU486)
1991 – approved in Great Britain and Sweden
1999 – approved in China
2000 – approved in US (Mifeprex)
In 2013, 45% of induced abortions at ≤ 9 weeks
gestation were medical abortions1
2015 – approved in Canada, available Jan.
2017
Approved in over 60 countries world wide
1. Jatlaoui TC et al. 2016.. CDC Abortion Surveillance. 2013.
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Uptake of mifepristone abortion
Berard V, Fiala C, et al. PloS ONE DOI: 10.1371/journal.pone.0112401
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Medical Abortion with
Mifegymiso
Mechanism of Action
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Mifepristone Blocks progesterone, causing:
Breakdown of endometrium through decidual necrosis
Softening of cervix
Induces contractions of the uterus
Increases sensitivity of uterine and cervical muscles to the
action of Misoprostol
http://www.chemspider.com/Chemical-Structure.49889.html
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Misoprostol
Synthetic Prostaglandin
Used to induce strong uterine contractions
Health Canada has approved its use along with
mifepristone in Mifegymiso
http://www.chemspider.com/Chemical-Structure.4445541.html
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Efficacy of Mifepristone + Miso
Very strong evidence for this protocol 1
A systematic review of 20 studies involving 33, 846
patients up to 70 days
When looking at 63 days only (~33,000)
96.7% for completed abortion
0.8% continued pregnancy
2.9 – 3.7% ER visits
1. Chen MJ and Creinin M.” Mifepristone with Buccal Misoprostol for Medical Abortion: a Systematic Review” ObstetGynecology 2015 126(1):12
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Medical Abortion ProtocolContraindications
Ectopic pregnancy
Chronic adrenal failure
Inherited porphyria
Known hypersensitivity to these medications
Ambivalence
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Medical Abortion ProtocolRelative Contraindications
Unconfirmed gestational age
needs ultrasound
IUD in place
remove first
Concurrent long-term systemic corticosteroid therapy
effectiveness suppressed for 3-4 days after mifepristone
Clotting disorder or anticoagulation
caution if anemic (hemoglobin <95mg/l)
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Medical Abortion with
Mifegymiso
Complications
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Retained Products 3.3% of women having a medical abortion need a
subsequent aspiration 1
Symptoms include prolonged bleeding and cramping or
failure of any bleeding 2
Can be managed by repeat misoprostol or aspiration
1. Chen MJ and Creinin M.” Mifepristone with Buccal Misoprostol for Medical Abortion: a Systematic Review” Obstet
Gynecology 2015 126(1):12
2. Costescu D et al. Medical Abortion CPG. JOGC 2016; 332: 366-389.
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Ongoing Pregnancy
Ongoing viable pregnancy found in < 1 % of MA less
than 63 days 1
1. Medical Abortion: Clinical Practice Guidelines: SOGC No. 332, April 2016
2. Chen MJ and Creinin M.” Mifepristone with Buccal Misoprostol for Medical Abortion: a Systematic Review” Obstet
Gynecology 2015 126(1):12
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Infection
Serious infection is very rare; <0.1 %
Serious infection = IV abx, hospitalization, sepsis, death
Most commonly endometritis or undefined genital tract
infection
Signs and symptoms – fever more than 24 hours after
miso, foul-smelling discharge, increasing pelvic pain,
Treatment – amoxicillin 500mg tid, metronidozole 500mg tid
for 14 days
1. Shannon C et al. “Infection after medical abortion: a review of literature” Contraception. 2004; 70(3):183
2. UpToDate – “Post Partum Endometritis” – accessed Feb. 2019.
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Infection – Bottom Line
Inform patients of to seek medical attention if showing
signs of infection or feeling unwell for 14 days following
mifepristone
Use buccal route for misoprostol
Screen for chlamydia and gonorrhea and treat
NO need for prophylactic antibiotics in Medical
Abortion
recommendation of SOGC, WHO, ACOG
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Hemorrhage
Rate of hemorrhage requiring IV fluid or transfusion
less than .1% 1
Patients should be counseled re: when to present to
ED – soaking more than 2 maxi pads an hour for more
than 2 hours in a row or orthostatic symptoms
1. Grimes DA. Medical abortion in early pregnancy: a review of the evidence. Obstet Gynecol 1997; 89: 790–796
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Providing a Medical Abortion
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Patient Selection Must be able to follow through with entire process:
appointments, calls, lab tests, access ER in case of
emergency
Able to have a surgical abortion if medical abortion fails
The process is irreversible once mifepristone is taken
due to high rate of teratogenicity
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Counseling Points Pain and Bleeding
o lower abdominal cramping will be severe for several
hours, then be moderate for a few days
o Bleeding – starts ~4 hours after taking misoprostol,
will pass blood, clots and whitish – grey tissue, may
last for 1-2 weeks
o Most women will pass the tissue within the first 24
hours
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MEDICAL SURGICAL
PROS• Can be done earlier in pregnancy• Seems more natural for some• More privacy at home• Less invasive• Can be with someone with you
PROS• Can be done later in pregnancy• Over in a few minutes• Higher success rate• Less bleeding• In a clinic/hospital setting
CONS• Takes longer• Bleeding can be heavy with tissue• It is a multi-step process• Must follow through with entire process
AVAILABILITY COST (in some areas)
CONS• Surgical procedure involving instruments
in vagina and uterus• Risk of procedure• Less control for woman, limits who can
be with her
AVAILABILITY TRAVEL TO CLINICS
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Medical Abortion Protocol
Preliminary Visit
• Options counseling
• Discuss medical vs. surgical abortion
• Determine gestational age – order ultrasound
• Blood type, beta HCG level, hemoglobin
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Medical Abortion Protocol
First Visit
Review results, give prescription for Mifegymiso
Counsel her about what to expect
Give requisition for follow up beta HCG
Confirm emergency contact
Confirm date she will take mifepristone, then the
timing of misoprostol, follow up beta HCG and
follow up appointment.
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Medical Abortion ProtocolFollow up Visit
Confirmation of completion
History alone is not adequate
beta HCG measurement:
A drop of 80% from pre-treatment levels on day 8 -16
confirms expulsion
Ultrasound, not superior to other methods
Contraception plan
OCP can be started on same day as misoprostol (use
condoms for 7 days)
IUD insertion
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Access to Medical Abortion:
Barriers
Announced on Friday September 22, 2017.
Cost
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Access to Medical Abortion:
Barriers
Province Universal Coverage Pharmacist
Dispensing
PEI ✗ ✗
NB ✔ ✗
NS ✔ ✔
Coverage and dispensing
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Access to Medical Abortion:
Barriers
03.03 V, 47.5 Units – since May 2018.
Inconsistent across the country, but most are
developing them
Billing Codes
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Training Resources and Support
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Training and Support SOGC website – on line learning
https://sogc.org/online-courses/welcome.html
Celopharma- manufacturer of Mifegymiso
http://celopharma.com/
CAPS – Canadian Abortion Provider Support
Online community hosted by UBC
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SOGC Medical abortion training program
Health Canada approved
Hosted by SOGC with support from CFPC and CPhA
Cost: $50 – 6 Mainpro credits
Modules:
1. Overview of medical abortion in Canada
2. Pre abortion care
3. Assessment of Unintended Pregnancy
4. Evidence Based Medical Abortion Regimen
5. Provision of Medical Abortion with the prior approved regimen
6. Post abortion Care
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SOGC Clinical Practice Guideline
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Celopharma Drug manufacturer website
Educational presentation
Handouts, consent form, FAQ
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CAPSCanadian Abortion Provider Support
Online community of support for medical abortion
providers and pharmacists
Confidential – providers only
Resource – FAQ, handouts, consent forms etc
“Ask the Expert”
“Find a Pharmacy”
Regional information and updates
Run and moderated out of UBC
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Over
700
physicians and
pharmacists have
completed a survey on
their mifepristone practice.
239 physicians
215 pharmacists
48 facility staff
33 nurse practitioners
3 midwives
have joined the CAPS community.
7% of physicians
worked in communities
with no prior abortion
service.
37% of physicians had never
provided abortions before.
The majority of
mifepristone providers are currently in
British Columbia, and Ontario.
MIFEPRISTONE IN CANADA
Who is providing abortions and where?
The Canadian Abortion Providers Support (CAPS-CPCA) website is an online community of practice for
practitioners and pharmacists that provide mifepristone.
Since January 2017 the Contraception and Abortion Research Team has been tracking the growth of this
community.
January 2018
![Page 52: Mifepristone Abortion in Your Office · Cost - $270.00 / package . Brief History of Mifepristone (RU486) ... Roussel-Uclaf, developed and tested for abortion • Approved in France](https://reader031.vdocuments.mx/reader031/viewer/2022013022/5f6a4002235e49711041b476/html5/thumbnails/52.jpg)
Acknowledgements Thank you to Dr. Wendy Norman and Dr. Sheila Dunn –
founders of CAPS for sharing slides
![Page 53: Mifepristone Abortion in Your Office · Cost - $270.00 / package . Brief History of Mifepristone (RU486) ... Roussel-Uclaf, developed and tested for abortion • Approved in France](https://reader031.vdocuments.mx/reader031/viewer/2022013022/5f6a4002235e49711041b476/html5/thumbnails/53.jpg)
Questions?
53