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Ch : p ng min dch dch th trong loi tr khng nguyn

P NG MIN DCH DCH TH TRONG LOI TR KHNG NGUYN NH TH NO? p ng min dch dch th l mt trong hai phng thc min dch c hiu m c th s dng loi tr khng nguyn

P NG MIN DCH DCH TH TRONG LOI TR KHNG NGUYN NH TH NO ?Lympho bo B chu trch nhim v min dch dch th thng qua cc sn phm ca n l cc khng th ha tan trong mu v cc dch th khc. Cc t bo lympho B cha c bit ha nhn din khng nguyn nhng khng ch tit khng th. S hot ho cc t bo lympho B ny s dn n bit ho chng thnh cc t bo thc hin ch tit khng th.

nh ngha: L tt c cc protein huyt thanh v nc tiu c tnh khng nguyn v cu trc ging nh globulin (KH:Ig)Cu trc gm 2 phn + Fab( phn gn KN):cc k thay i kt hp vi nhiu KN khc nhau+ Fc( phn c nh): hot ha b thKhng th dch th

1. Nhn din khng nguyn2. hot ha lympho B3. Loi tr khng nguyn 4. Tnh hng nh ni m gim dn p ng

Qu trnh p ng min dch dch th tri qua 4 giai on:

Khng nguyn(KN) xm nhp s b i thc bo bt-nut-tiu=> i thc bo mang KN x l n hch lympho gn nht truyn thng tin cho lymphoB1. Nhn din khng nguyn

i hi 2 tn hiu khc nhau:+Khng nguyn=> nhm m bo tnh c hiu ca p ng min dch+ Cc sn phm VSV hoc cc thnh phn ca p ng min dch bm sinh i vi VSV=> m bo phn ng ch c to ra khi cn thit2. Hot ha lympho B

Lympho bo tri qua qu trnh tng sinh v bit ha v cui cng tr thnh tng bo, 1 s khc tr thnh t bo nh

_Khng th kt hp c hiu vi khng nguyn mnh Fab ch tn cngKt qu: Phc hp KN_KT c tc dng trung ha c t,gim c tnh ca c t, to mng li ngng kt, ngng t vi vi khun, nm nh hn ch c kh nng gy bnh ca chng.Trn phn Fc ca IgG1,2,3 v IgM c th th cho C1q ca b th. Khi KN kt hp vi Kt lm thay i cu hnh khng gian ca Ig bc l v tr kt hp ca b th C1q gn vo.

3. Loi tr khng nguyn

-IgE, IgG4 c kh nng lin kt vi dng bo v bch cu i kim nh nhng Recepter ca chng vi phn Fc. Khi phn Fab ca Ig kt hp vi KN=> hot ha t bo ny, gii phng ha cht TG nh histamin , serotonin => tng tnh thm mao mch, co c trn=> khng th v TB thc bo d dng lt qua thnh mch ti ni KN xm nhpHin tng opsonin ha: qu trnh tng cng thc bo cu i thc boTb NK c th th vi Fc ca IgG, do d tip cn, tiu dit t bo ch, gy c t bo ph thuc khng th

Cui p ng min dch, h thng MD tr li trng thi ngh ngi c bn do phn ln TB tin thn ca Lympho b KN kch thch cht do hin tng cht lp trnh(apoptosis)Hin tng cht lp trnh l hin tng cht sinh l chun b trc i lp vi hoi t4. Tnh hng nh ni m gim dn p ng

Cm n thy c v cc bn ch lng nghe